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https://www.readbyqxmd.com/read/29785138/a-review-of-soft-tissue-sarcomas-translation-of-biological-advances-into-treatment-measures
#1
REVIEW
Ngoc T Hoang, Luis A Acevedo, Michael J Mann, Bhairavi Tolani
Soft-tissue sarcomas are rare malignant tumors arising from connective tissues and have an overall incidence of about five per 100,000 per year. While this diverse family of malignancies comprises over 100 histological subtypes and many molecular aberrations are prevalent within specific sarcomas, very few are therapeutically targeted. Instead of utilizing molecular signatures, first-line sarcoma treatment options are still limited to traditional surgery and chemotherapy, and many of the latter remain largely ineffective and are plagued by disease resistance...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29759566/role-of-bevacizumab-in-uterine-leiomyosarcoma
#2
REVIEW
Giorgio Bogani, Antonino Ditto, Fabio Martineli, Mauro Signorelli, Valentina Chiappa, Caterina Fonatella, Roberta Sanfilippo, Umberto Leone Roberti Maggiore, Simone Ferrero, Domenica Lorusso, Francesco Raspagliesi
In the recent years, angiogenetic inhibitors have emerged for the treatment of several malignancies. In particular, bevacizumab has proved to be effective in many types of cancers (including sarcoma), but the limitations of antiangiogenic therapy have been shown in practice. Here, we sought to review the current evidence on the role and efficacy of bevacizumab in patients affected by uterine leiomyosarcoma. On April 2017, Literature was searched in order to identify studies reporting outcomes of patients affected either by early stage or advanced/recurred uterine leiomyosarcoma undergoing treatment with bevacizumab, alone or in combination with other chemotherapeutic regimens...
June 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29744029/treatment-patterns-and-survival-among-older-adults-in-the-united-states-with-advanced-soft-tissue-sarcomas
#3
Rohan C Parikh, Maria Lorenzo, Lisa M Hess, Sean D Candrilli, Steven Nicol, James A Kaye
Background: To describe patient and tumor characteristics, treatments, and survival among older adults in the United States with advanced soft-tissue sarcoma (STS), across and by categories of specifically defined histologic subtypes. Methods: We conducted a retrospective cohort analysis using the SEER. The study population comprised patients ≥ 65 years old with advanced STS (excluding osteosarcoma, Kaposi sarcoma, and gastrointestinal stromal tumors) diagnosed from January 1, 2001 to December 31, 2011...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29743950/multimodality-management-of-leiomyosarcoma-of-the-cervix
#4
Vijaya Kumar Jayaram, J Parikshith, Geeta Sowmya Narayanan, Richa Tiwari, R Veena, S Prathima, M S Ganesh, Chattakonda Sai Snehith, Esther Praisy
We present the case of a young female patient who presented to the outpatient department with a history of bleeding per vagina, diagnosed with leiomyosarcoma of the cervix; the patient underwent total abdominal hysterectomy with pelvic lymph node dissection. In this article, we mainly discuss multimodality therapy in the management of an unusual variety of tumour in the uterine cervix.
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29729268/treatment-approaches-and-outcomes-for-primary-mediastinal-sarcoma-analysis-of-976-patients
#5
Kathryn E Engelhardt, Malcolm M DeCamp, Anthony D Yang, Karl Y Bilimoria, David D Odell
BACKGROUND: Primary mediastinal sarcomas are rare and deadly. Our objective was to describe the clinicopathological features, treatment strategies, and overall survival outcomes for a contemporary cohort of patients diagnosed with primary mediastinal sarcoma in the United States. METHODS: We queried the National Cancer Database for cases of mediastinal sarcoma diagnosed from 2004-2012. Five-year overall survival (OS) was examined using the Kaplan-Meier method. Differences in OS were assessed using log-rank analysis and Cox proportional hazards regression...
May 2, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29724518/response-and-overall-survival-for-yttrium-90-radioembolization-of-hepatic-sarcoma-a-multicenter-retrospective-study
#6
Matthew D Miller, Daniel Y Sze, Siddharth A Padia, Robert J Lewandowski, Riad Salem, Philani Mpofu, Paul M Haste, Matthew S Johnson
PURPOSE: To evaluate the effectiveness and safety of yttrium-90 transarterial radioembolization (TARE) for the treatment of primary and metastatic soft tissue sarcoma (STS) of the liver. MATERIALS AND METHODS: A retrospective review of 39 patients with primary (n = 2) and metastatic (n = 37) hepatic STS treated with TARE at 4 institutions was performed. Fourteen STS subtypes were included, with leiomyosarcoma being the most common (51%). TARE with glass (22 patients) or resin (17 patients) microspheres was performed, with single lobe (17 patients) or bilobar treatment (22 patients) based on disease burden...
April 30, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29703030/primary-leiomyosarcoma-of-the-fallopian-tube-a-case-report-and-literature-review
#7
Di You, Qilin Wang, Wei Jiang, Lin Lin, Tianjin Yi, Lingjun Zhao, Maomao Li, Ping Wang
RATIONALE: Primary leiomyosarcoma (LMS) of the fallopian tube is extremely uncommon. To the best of our knowledge, so far only 21 cases of primary fallopian tube LMS have been reported in English-language literature. No new case has been reported in the past 7 years. PATIENT CONCERNS: A 44-year-old premenopausal patient presented with a 5-day history of lower abdominal pain. DIAGNOSES: Pelvic ultrasonography detected an 8.8 × 7.8 × 6...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29683931/value-of-18f-fdg-pet-ct-imaging-in-the-staging-restaging-monitoring-of-response-to-therapy-and-surveillance-of-uterine-leiomyosarcomas
#8
Ophélie Bélissant, Laurence Champion, Hind Thevenet, Pierre Weinmann, Jean-Louis Alberini
OBJECTIVE: Leiomyosarcoma (LMS) is the most common subtype of uterine sarcomas. It is a rare and aggressive tumour. The aim of the present study was to assess the performance of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT imaging in four clinical settings: initial staging, restaging, monitoring of response to therapy and post-therapy surveillance of uterine LMS. PATIENTS AND METHODS: A bicentric retrospective study was carried out on a group of 21 patients with uterine LMS for whom a total of 52 PET/CT scans were available in initial staging (n=11), restaging (n=11), monitoring of response to therapy (n=17) and post-therapy surveillance (n=13)...
July 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29588301/leiomyosarcoma-a-rare-sinonasal-malignancy
#9
Matthew Ming Kei Kwok, Stewart Lee, Patrick Hosking
Leiomyosarcomas (LMS) are rare sinonasal malignant tumours with 20 cases of nasal LMS previously reported in the literature. An 81-year-old man presented with an incidental left nasal lesion associated with left nasal obstruction and occasional left-sided blood-stained rhinorrhoea. Nasendoscopic examination showed green coloured polyps filling the left nasal cavity with biopsies showing LMS. CT imaging did not show any bony erosion. No metastases were found on positron emission tomography imaging. The patient underwent endoscopic resection and all surgical margins were clear of disease...
March 27, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29579884/prevalence-and-survival-of-cancer-after-pancreas-kidney-transplantation
#10
M V Pendón-Ruiz de Mier, M L Agüera, M D Navarro, A Rodriguez-Benot, P Aljama
BACKGROUND: Malignancy is an important cause of mortality in solid organ transplantation. There have been few studies of de novo solid organ malignancy (NSOM) after pancreas-kidney transplantation (PKT). The aim of this study was analyze the prevalence of NSOM and transplant outcomes. METHODS: We studied the development of NSOM after PKT in our center from May 1990 to February 2017. We analyzed demographic characteristics, prevalence of cancer, and survival after cancer diagnosis...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29556383/secondary-cytoreductive-surgery-potentially-improves-the-oncological-outcomes-of-patients-with-recurrent-uterine-sarcomas
#11
Kenichi Nakamura, Hiroaki Kajiyama, Fumi Utsumi, Shiro Suzuki, Kaoru Niimi, Ryuichiro Sekiya, Jun Sakata, Eiko Yamamoto, Kiyosumi Shibata, Fumitaka Kikkawa
Uterine sarcomas are some of the most malignant and aggressive tumor types among the gynecologic malignancies, and they are associated with a high rate of recurrence and a poor prognosis. Due to their rarity and diversity, the optimal treatment for recurrent uterine sarcomas has not yet been elucidated. The aim of the present study was to investigate the potential of secondary cytoreductive surgery (SCS) for patients with recurrent uterine sarcomas. A total of 18 patients with recurrent uterine sarcomas were retrospectively identified at the Department of Obstetrics and Gynecology, Nagoya University (Nagoya, Japan) between January 2002 and December 2015...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29549682/primary-thyroid-leiomyosarcoma-a-case-report-and-review-of-the-literature
#12
G L Canu, J S Bulla, M L Lai, F Medas, G Baghino, E Erdas, S Mariotti, P G Calò
Primary thyroid leiomyosarcoma (LMS) is an extremely rare tumor. We report a case of a 47-year-old male with a rapidly growing neck mass and disfagia. Preoperative investigations were diagnostic of anaplastic carcinoma. Total thyroidectomy with partial esophagectomy and dissection of right infrahyoid muscles was performed. Through histolological and immunohistochemical evaluations a primary thyroid high-grade LMS was diagnosed. At 2 months of follow-up a local recurrence was detected and consequently the patient was submitted to chemotherapy with partial response...
January 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29515415/long-lasting-response-to-trabectedin-in-a-patient-with-metastatic-uterine-leiomyosarcoma-a-case-report
#13
Viktoria-Anna Nteli, Wolfgang Knauf, Anja Janton-Klein, Samer El-Safadi
Background: Uterine leiomyosarcoma (uLMS) is a rare tumor that accounts for 1% of all uterine malignancies. In spite of adequate surgical resection of uLMS, even in the early stage, patients remain at high risk for local and distant recurrence. Therefore, the treatment of advanced uLMS represents a considerable challenge. Methods: We report the case of a 47-year-old woman who presented with uLMS with abnormal vaginal bleeding. Results: The patient underwent a total hysterectomy and bilateral adnexectomy, which was followed by 1 year progression-free survival without adjuvant therapy...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29510462/development-of-a-pelvic-exenteration-service-at-a-tertiary-referral-centre
#14
Marilla Dickfos, Stephanie B M Tan, Andrew R L Stevenson, Craig A Harris, Rachel Esler, Matthew Peters, David G Taylor
BACKGROUND: Over one-third of primary rectal cancers are locally advanced at diagnosis, and local recurrence of rectal cancer occurs at a rate of 3-10% following primary curative resection. Extended resectional surgery, including pelvic exenteration, is the only proven therapy with curative potential in the treatment of these cancers along with many other pelvic malignancies. A microscopically clear resection margin (R0 resection) is the predominant prognostic factor affecting overall and disease-free survival...
March 6, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29491084/functionality-of-the-tumor-suppressor-microrna-1-in-malignant-tissue-and-cell-line-cells-of-uterine-leiomyosarcoma
#15
Matthias B Stope, Victor Cernat, Anne Kaul, Karoline Diesing, Dominique Koensgen, Martin Burchardt, Alexander Mustea
BACKGROUND/AIM: Uterine leiomyosarcoma (uLMS) is a very rare mesenchymal tumor showing an aggressive clinical course and poor prognosis for patients. Due to the low incidence, little is known about molecular tumor biology and biomarkers of uLMS. Micro-RNA-1 (miR-1) has been identified as a pivotal tumor suppressor in numerous entities being suited as a molecular marker for tumor progression. MATERIALS AND METHODS: uLMS patient samples were analyzed regarding their miR-1 expression levels...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29487221/a-phase-ii-study-of-tumor-ablation-in-patients-with-metastatic-sarcoma-stable-on-chemotherapy
#16
Angela C Hirbe, Jack Jennings, Nael Saad, Joseph D Giardina, Yu Tao, Jingqin Luo, Shellie Berry, Jacqui Toeniskoetter, Brian A Van Tine
LESSONS LEARNED: Ablation therapy appears to be a reasonably safe and effective approach to obtain a significant treatment-free interval for a subset of patients with limited sites of metastatic disease for which systemic control can be obtained with six cycles of chemotherapy. BACKGROUND: Metastatic sarcoma often becomes resistant to treatment by chemotherapy. There is sometimes prolonged stable disease from active chemotherapy that provides a window of opportunity for an intervention to prolong disease-free survival...
February 27, 2018: Oncologist
https://www.readbyqxmd.com/read/29483414/-iii-chemotherapy-targeted-therapy-and-immunotherapy-for-uterine-leiomyosarcoma
#17
Kosei Hasegawa
No abstract text is available yet for this article.
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29462961/a-phase-i-ii-study-targeting-angiogenesis-using-bevacizumab-combined-with-chemotherapy-and-a-histone-deacetylase-inhibitor-valproic-acid-in-advanced-sarcomas
#18
Varun Monga, Umang Swami, Munir Tanas, Aaron Bossler, Sarah L Mott, Brian J Smith, Mohammed Milhem
Epigenetic events and genetic alterations under the control of the tumor microenvironment potentially mediate tumor induced angiogenesis involved in soft tissue sarcoma (STS) metastasis. Addition of antiangiogenic agent, such as bevacizumab, to standard chemotherapy in treatment of sarcoma has been studied in clinical trials, but most of the findings have not supported its use. We hypothesized the existence of an epigenetically mediated "angiogenic switch", and the tumor microenvironment, prevents bevacizumab from truly blocking angiogenesis...
February 17, 2018: Cancers
https://www.readbyqxmd.com/read/29458779/systemic-treatment-in-adult-uterine-sarcomas
#19
REVIEW
I M E Desar, P B Ottevanger, C Benson, W T A van der Graaf
Uterine sarcomas (US) are rare mesenchymal tumours of the uterus and are divided mainly into uterine leiomyosarcoma (uLMS), low grade endometrial stromal sarcoma (LG-ESS), high grade endometrial stromal sarcoma (HG-ESS), adenosarcomas and high grade undifferentiated sarcoma (HGUS). US are often high-grade tumours with a high local recurrence rate and metastatic risk. We here discuss the current standard of care and knowledge of systemic therapy for adult uterine sarcomas, in particular uLMS, LG-ESS, HG-ESS and HGUS, in both the adjuvant as well as the metastatic setting...
February 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29417238/options-for-adjuvant-therapy-for-uterine-leiomyosarcoma
#20
REVIEW
Claire F Friedman, Martee L Hensley
Uterine leiomyosarcoma (uLMS) is a rare disease; in the data from the SEER database, 3165 cases of uLMS were diagnosed between January 2000 and December 2012. While a majority of patients (60%) are diagnosed with early stage disease, recurrence rates are high. Five-year disease-specific survival is 76% for patients with FIGO stage I and 60% for patients with FIGO stage II disease. Adjuvant treatments, including radiation therapy, chemotherapy, and combined modality approaches, have been explored with the goal of demonstrating improved survival...
February 8, 2018: Current Treatment Options in Oncology
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