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https://www.readbyqxmd.com/read/29663119/multicenter-data-banking-in-management-of-dizzy-patients-first-results-from-the-dizzynet-registry-project
#1
Eva Grill, Gülden Akdal, Sandra Becker-Bense, Steffen Hübinger, Doreen Huppert, Erna Kentala, Ralf Strobl, Andreas Zwergal, Nese Celebisoy
PURPOSE: Comprehensive phenotypical data across countries is needed to understand the determinants, prognosis and consequences of vestibular disease. The registry is a data repository for the members of the European DizzyNet. We report results from a pilot study using data from Turkey and Germany. METHODS: The pilot study included a convenience sample of patients aged 18 or above referred to Ege University Medical School Hospital, Dokuz Eylül University Hospital, Izmir, Turkey, and the German Center for German Center for Vertigo and Balance Disorders, University on Munich, Germany, with symptoms of vertigo or dizziness...
April 16, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29608386/patient-centred-goal-setting-in-a-hospice-a-comparative-case-study-of-how-health-practitioners-understand-and-use-goal-setting-in-practice
#2
Sally Boa, Edward Duncan, Erna Haraldsdottir, Sally Wyke
BACKGROUND: Goal setting is recognised as an important way of supporting people to live as actively as possible until death. However, there is little agreement about how goal setting should be handled or delivered by health professionals in everyday practice. AIM: To investigate health-care practitioners' understanding and practice of patient-centred goal setting in a hospice. METHODS: A comparative case study of 10 healthcare practitioners in one hospice...
March 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29602043/a-survey-of-recently-emerged-genome-wide-computational-enhancer-predictor-tools
#3
REVIEW
Leonard Whye Kit Lim, Hung Hui Chung, Yee Ling Chong, Nung Kion Lee
The race for the discovery of enhancers at a genome-wide scale has been on since the commencement of next generation sequencing decades after the discovery of the first enhancer, SV40. A few enhancer-predicting features such as chromatin feature, histone modifications and sequence feature had been implemented with varying success rates. However, to date, there is no consensus yet on the single enhancer marker that can be employed to ultimately distinguish and uncover enhancers from the enormous genomic regions...
March 16, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29570845/melatonin-and-cardioprotection-against-ischaemia-reperfusion-injury-what-s-new
#4
REVIEW
Amanda Lochner, Erna Marais, Barbara Huisamen
Melatonin is a pleiotropic hormone with several functions. It binds to specific receptors and to a number of cytosolic proteins, activating a vast array of signalling pathways. Its potential to protect the heart against ischaemia/reperfusion damage has attracted much attention, particularly in view of its possible clinical applications. This review will focus mainly on the possible signalling pathways involved in melatonin-induced cardioprotection. In particular, the role of the melatonin receptors and events downstream of receptor activation, for example, the Reperfusion Injury Salvage Kinase (RISK), Survivor Activating Factor Enhancement (SAFE) and Notch pathways, the sirtuins, nuclear factor E2-related factor 2 (Nrf2) and translocases in the outer membrane (TOM70) will be discussed...
March 23, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29568288/serological-evidence-of-orthopoxvirus-circulation-among-equids-southeast-brazil
#5
Iara A Borges, Mary G Reynolds, Andrea M McCollum, Poliana O Figueiredo, Lara L D Ambrosio, Flavia N Vieira, Galileu B Costa, Ana C D Matos, Valeria M de Andrade Almeida, Paulo C P Ferreira, Zélia I P Lobato, Jenner K P Dos Reis, Erna G Kroon, Giliane S Trindade
Since 1999 Vaccinia virus (VACV) outbreaks involving bovines and humans have been reported in Brazil; this zoonosis is known as Bovine Vaccinia (BV) and is mainly an occupational disease of milkers. It was only in 2008 (and then again in 2011 and 2014) however, that VACV was found causing natural infections in Brazilian equids. These reports involved only equids, no infected humans or bovines were identified, and the sources of infections remain unknown up to date. The peculiarities of Equine Vaccinia outbreaks (e...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29561772/the-host-factor-early-growth-response-gene-egr-1-regulates-vaccinia-virus-infectivity-during-infection-of-starved-mouse-cells
#6
Leonardo C de Oliveira, Bruno S A F Brasil, Bethany Unger, Giliane S Trindade, Jonatas S Abrahão, Erna G Kroon, Paula Traktman, Cláudio A Bonjardim
Evolution has equipped poxvirus genomes with the coding capacity for several virus-host interaction products which interfere with host cell gene expression and protein function, creating an adequate intracellular environment for a productive infection. We show here that Vaccinia virus (VACV) induces the expression of the cellular transcription factor EGR-1 (early growth response-1) in Mouse Embryonic Fibroblasts (MEFs) through the MEK (mitogen-activated protein kinase (MAPK)/ERK)/ERK (extracellular signal-regulated kinases) pathway, from 3 to 12 h post infection (h...
March 21, 2018: Viruses
https://www.readbyqxmd.com/read/29552190/prognostic-value-of-alcohol-dehydrogenase-mrna-expression-in-gastric-cancer
#7
Erna Guo, Haotang Wei, Xiwen Liao, Yang Xu, Shu Li, Xiaoyun Zeng
Previous studies have reported that alcohol dehydrogenase (ADH) isoenzymes possess diagnostic value in gastric cancer (GC). However, the prognostic value of ADH isoenzymes in GC remains unclear. The aim of the present study was to identify the prognostic value of ADH genes in patients with GC. The prognostic value of ADH genes was investigated in patients with GC using the Kaplan-Meier plotter tool. Kaplan-Meier plots were used to assess the difference between groups of patients with GC with different prognoses...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29527059/history-of-child-and-adolescent-psychiatry-at-central-institute-of-psychiatry-journey-of-erna-hoch-centre-for-child-and-adolescent-psychiatry
#8
REVIEW
Vinod Sinha, Nishant Goyal, Joyita Sinha
Child and adolescent psychiatry has not been considered as an established field until the early 1900s till first such unit was started by Leo Kanner in 1930. In India, the first child guidance clinic was founded in 1938 in Mumbai by Dr. Clifford Manshardt. The child and adolescent Psychiatry unit at Central institute of Psychiatry has been into existence for the last 55 years and since then it has been an integral part of the institute in providing high-quality patient care, promoting substantial growth in research, and imparting education to the post graduate trainees and scholars in the field of child psychiatry...
February 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29511351/hpse-enhancer-rna-promotes-cancer-progression-through-driving-chromatin-looping-and-regulating-hnrnpu-p300-egr1-hpse-axis
#9
Wanju Jiao, Yajun Chen, Huajie Song, Dan Li, Hong Mei, Feng Yang, Erhu Fang, Xiaojing Wang, Kai Huang, Liduan Zheng, Qiangsong Tong
Recent studies reveal the emerging functions of enhancer RNAs (eRNAs) in gene expression. However, the roles of eRNAs in regulating the expression of heparanase (HPSE), an established endo-β-D-glucuronidase essential for cancer invasion and metastasis, still remain elusive. Herein, through comprehensive analysis of publically available FANTOM5 expression atlas and chromatin interaction dataset, we identified a super enhancer and its derived eRNA facilitating the HPSE expression (HPSE eRNA) in cancers. Gain-of-function and loss-of-function experiments indicated that HPSE eRNA facilitated the in vitro and in vivo tumorigenesis and aggressiveness of cancer cells...
March 7, 2018: Oncogene
https://www.readbyqxmd.com/read/29507337/cedratvirus-getuliensis-replication-cycle-an-in-depth-morphological-analysis
#10
Ludmila Karen Dos Santos Silva, Ana Cláudia Dos Santos Pereira Andrade, Fábio Pio Dornas, Rodrigo Araújo Lima Rodrigues, Thalita Arantes, Erna Geessien Kroon, Cláudio Antônio Bonjardim, Jônatas Santos Abrahão
The giant viruses are the largest and most complex viruses in the virosphere. In the last decade, new members have constantly been added to this group. Here, we provide an in-depth descriptive analysis of the replication cycle of Cedratvirus getuliensis, one of the largest viruses known to date. We tracked the virion entry, the early steps of virus factory and particles morphogenesis, and during this phase, we observed a complex and unique sequential organization of immature particle elements, including horseshoe and rectangular compartments, revealed by transverse and longitudinal sections, respectively, until the formation of the final ovoid-shaped striped virion...
March 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29487281/tailed-giant-tupanvirus-possesses-the-most-complete-translational-apparatus-of-the-known-virosphere
#11
Jônatas Abrahão, Lorena Silva, Ludmila Santos Silva, Jacques Yaacoub Bou Khalil, Rodrigo Rodrigues, Thalita Arantes, Felipe Assis, Paulo Boratto, Miguel Andrade, Erna Geessien Kroon, Bergmann Ribeiro, Ivan Bergier, Herve Seligmann, Eric Ghigo, Philippe Colson, Anthony Levasseur, Guido Kroemer, Didier Raoult, Bernard La Scola
Here we report the discovery of two Tupanvirus strains, the longest tailed Mimiviridae members isolated in amoebae. Their genomes are 1.44-1.51 Mb linear double-strand DNA coding for 1276-1425 predicted proteins. Tupanviruses share the same ancestors with mimivirus lineages and these giant viruses present the largest translational apparatus within the known virosphere, with up to 70 tRNA, 20 aaRS, 11 factors for all translation steps, and factors related to tRNA/mRNA maturation and ribosome protein modification...
February 27, 2018: Nature Communications
https://www.readbyqxmd.com/read/29475721/a-cross-taxa-study-using-environmental-dna-rna-metabarcoding-to-measure-biological-impacts-of-offshore-oil-and-gas-drilling-and-production-operations
#12
Olivier Laroche, Susanna A Wood, Louis A Tremblay, Joanne I Ellis, Gavin Lear, Xavier Pochon
Standardized ecosystem-based monitoring surveys are critical for providing information on marine ecosystem health. Environmental DNA/RNA (eDNA/eRNA) metabarcoding may facilitate such surveys by quickly and effectively characterizing multi-trophic levels. In this study, we assessed the suitability of eDNA/eRNA metabarcoding to evaluate changes in benthic assemblages of bacteria, Foraminifera and other eukaryotes along transects at three offshore oil and gas (O&G) drilling and production sites, and compared these to morphologically characterized macro-faunal assemblages...
February 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29468919/health-related-quality-of-life-in-hearing-impaired-adolescents-and-children
#13
Riina Niemensivu, Risto Paavo Roine, Harri Sintonen, Erna Kentala
OBJECTIVE: To evaluate health-related quality of life (HRQoL) in hearing-impaired adolescents and children and to compare it with that of hearing individuals. STUDY DESIGN AND SETTING: Hearing-impaired adolescents and children were recruited to the study during their annual control visit to the Hearing Clinic of Helsinki University Hospital. They filled in a HRQoL questionnaire, either the 16-dimensional 16D (adolescents aged 12-17 years) or the 17-dimensional 17D (children aged 7-11 years)...
February 22, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29466941/transcription-start-site-profiling-uncovers-divergent-transcription-and-enhancer-associated-rnas-in-drosophila-melanogaster
#14
Michael P Meers, Karen Adelman, Robert J Duronio, Brian D Strahl, Daniel J McKay, A Gregory Matera
BACKGROUND: High-resolution transcription start site (TSS) mapping in D. melanogaster embryos and cell lines has revealed a rich and detailed landscape of both cis- and trans-regulatory elements and factors. However, TSS profiling has not been investigated in an orthogonal in vivo setting. Here, we present a comprehensive dataset that links TSS dynamics with nucleosome occupancy and gene expression in the wandering third instar larva, a developmental stage characterized by large-scale shifts in transcriptional programs in preparation for metamorphosis...
February 21, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29463554/combination-approach-for-detecting-different-types-of-alterations-in-circulating-tumor-dna-in-leiomyosarcoma
#15
Joanna Przybyl, Jacob J Chabon, Lien Spans, Kristen Ganjoo, Sujay Vennam, Aaron M Newman, Erna Forgó, Sushama Varma, Shirley Zhu, Maria Debiec-Rychter, Ash A Alizadeh, Maximilian Diehn, Matt van de Rijn
PURPOSE: The clinical utility of circulating tumor DNA (ctDNA) monitoring has been shown in tumors that harbor highly recurrent mutations. Leiomyosarcoma (LMS) represents a type of tumor with a wide spectrum of heterogeneous genomic abnormalities; thus, targeting hotspot mutations or a narrow genomic region for ctDNA detection may not be practical. Here we demonstrate a combinatorial approach that integrates different sequencing protocols for the orthogonal detection of single nucleotide variants (SNVs), small indels and copy number alterations (CNAs) in ctDNA...
February 20, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29462598/using-adult-aedes-aegypti-females-to-predict-areas-at-risk-for-dengue-transmission-a-spatial-case-control-study
#16
Maisa Carla Pereira Parra, Eliane Aparecida Fávaro, Margareth Regina Dibo, Adriano Mondini, Álvaro Eduardo Eiras, Erna Geessien Kroon, Mauro Martins Teixeira, Mauricio Lacerda Nogueira, Francisco Chiaravalloti-Neto
INTRODUCTION: Traditional indices for measuring dengue fever risk in a given area are based on the immature forms of the vector (larvae and pupae surveys). However, this is inefficient because only adult female mosquitoes actually transmit the virus. Based on these assumptions, our objective was to evaluate the association between an entomological index obtained from adult mosquito traps and the occurrence of dengue in a hyperendemic area. Additionally, we compared its cost to that of the Breteau Index (BI)...
February 17, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29452366/prevalence-and-incidence-of-anal-and-cervical-high-risk-human-papillomavirus-hpv-types-covered-by-current-hpv-vaccines-among-hiv-infected-women-in-the-study-to-understand-the-natural-history-of-hiv-aids-in-the-era-of-effective-therapy-the-sun-study
#17
Erna Milunka Kojic, Lois Conley, Tim Bush, Susan Cu-Uvin, Elizabeth R Unger, Keith Henry, John Hammer, Gerome Escota, Teresa M Darragh, Joel M Palefsky, John T Brooks, Pragna Patel
Background: Nonavalent (9v) human papilloma virus vaccine targets high-risk (HR)-HPV types 16, 18, 31, 33, 45, 52, 58, and low-risk 6, 11. We examined prevalence, incidence, and clearance of anal and cervical HR-HPV in HIV-infected women. Methods: From 2004-2006, the SUN Study enrolled 167 women from four US cities. Anal and cervical specimens were collected annually for cytology and identification of 37 HPV types; 14 HR include: 9v 16, 18, 31, 33, 45, 52, 58; non-9v 35, 39, 51, 56, 59, 66, 68...
February 14, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29449408/enhancer-rna-profiling-predicts-transcription-factor-activity
#18
Joseph G Azofeifa, Mary A Allen, Josephina R Hendrix, Timothy Read, Jonathan D Rubin, Robin D Dowell
Transcription factors (TFs) exert their regulatory influence through the binding of enhancers, resulting in coordination of gene expression programs. Active enhancers are often characterized by the presence of short, unstable transcripts termed enhancer RNAs (eRNAs). While their function remains unclear, we demonstrate that eRNAs are a powerful readout of TF activity. We infer sites of eRNA origination across hundreds of publicly available nascent transcription data sets and show that eRNAs initiate from sites of TF binding...
February 15, 2018: Genome Research
https://www.readbyqxmd.com/read/29440798/rural-palliative-care-in-north-india-rapid-evaluation-of-a-program-using-a-realist-mixed-method-approach
#19
Daniel F Munday, Erna Haraldsdottir, Manju Manak, Ann Thyle, Cathy M Ratcliff
Context: Palliative care has not developed widely in rural North India. Since 2010, the Emmanuel Hospitals Association (EHA) has been developing a model of palliative care appropriate for this setting, based on teams undertaking home visits with the backup of outpatient and inpatient services. A project to further develop the model operated from 2012 to 2015 supported by funding from the UK. Aims: This study aims to evaluate the EHA palliative care project. Settings and Design: Rapid evaluation method using a mixed method realist approach at the five project hospital sites...
January 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29427676/in-vitro-susceptibility-to-st-246-and-cidofovir-corroborates-the-phylogenetic-separation-of-brazilian-vaccinia-virus-into-two-clades
#20
Mariana A Pires, Nathália F S Rodrigues, Danilo B de Oliveira, Felipe L de Assis, Galileu B Costa, Erna G Kroon, Bruno E F Mota
The Orthopoxvirus (OPV) genus of the Poxviridae family contains several human pathogens, including Vaccinia virus (VACV), which have been implicating in outbreaks of a zoonotic disease called Bovine Vaccinia in Brazil. So far, no approved treatment exists for OPV infections, but ST-246 and Cidofovir (CDV) are now in clinical development. Therefore, the objective of this work was to evaluate the susceptibility of five strains of Brazilian VACV (Br-VACV) to ST-246 and Cidofovir. The susceptibility of these strains to both drugs was evaluated by plaque reduction assay, extracellular virus's quantification in the presence of ST-246 and one-step growth curve in cells treated with CDV...
February 7, 2018: Antiviral Research
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