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https://www.readbyqxmd.com/read/29225621/improved-health-status-and-life-satisfaction-among-older-people-following-self-help-group-intervention-in-jakarta
#1
Junaiti Sahar, Ni Made Riasmini, Dwi Nurviyandari Kusumawati, Erna Erawati
Although self-help group for older people gains the effectiveness, the effect of a nursing intervention using a self-help group model as a guideline for self-monitoring and intervention on the health status and life satisfaction among older people still remains. To determine the effectiveness of this nursing intervention, an experimental design using multistage sampling method was used for this study. The self-help intervention included a single 50-70-minute session once a week for 12 weeks done, using the Life Satisfaction Inventory-A (LSI-A) questionnaire, and SF-36 shows a significant difference...
2017: Current Gerontology and Geriatrics Research
https://www.readbyqxmd.com/read/29224135/serum-ferritin-and-obstructive-sleep-apnea-epidemiological-study
#2
Elin H Thorarinsdottir, Erna S Arnardottir, Bryndis Benediktsdottir, Christer Janson, Isleifur Olafsson, Allan I Pack, Thorarinn Gislason, Brendan T Keenan
PURPOSE: Ferritin is an intracellular iron storage protein and a marker of inflammation. Studies have shown that subjects with obstructive sleep apnea (OSA) have higher levels of circulating pro-inflammatory cytokines, but little is known about the association between ferritin and OSA. The aims of the study were to evaluate serum ferritin (S-Ferritin) levels in OSA patients compared to levels in the general population and also examine the effect of obesity level and treatment with positive airway pressure (PAP) on S-Ferritin levels...
December 9, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29221031/robust-interferometer-with-external-phase-shift-control
#3
José A Ferrari, Jorge L Flores, Gastón A Ayubi, Erna Frins
We describe a robust interferometer with external phase-shift control that does not require moving parts. The optical architecture resembles a common-path device in which the interfering waves propagate together in one collimated beam passing through the test sample. The collimated beam is incident on a calcite plate, which produces a polarization selective lateral translation and superposition of the reference and test waves. The characteristic features of the proposed interferometer, i.e. one-beam single-element scheme combined with external phase-shift control without moving parts, make a highly vibration insensitive device...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29211874/prevalence-incidence-and-clearance-of-anal-high-risk-human-papillomavirus-hpv-infection-among-hiv-infected-men-in-the-sun-study
#4
Pragna Patel, Tim Bush, Erna Milunka Kojic, Lois Conley, Elizabeth R Unger, Teresa M Darragh, Keith Henry, John Hammer, Gerome Escota, Joel M Palefsky, John T Brooks
Background: The natural history of anal HPV infection among HIV-infected men is unknown. Methods: We collected anal swabs for cytology, HPV detection, and genotyping at annual visits from 2004-2012. We examined baseline prevalence, incidence and clearance of anal HPV infection at 48 months, and associated factors among HIV-infected men. Results: We examined 403 men who have sex with men (MSM) and 96 men who have sex with women (MSW) (median age 42 years for both, 87 vs...
December 4, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29194182/effect-of-post-activation-potentiation-induced-by-elastic-resistance-on-kinematics-and-performance-in-a-roundhouse-kick-of-trained-martial-arts-practitioners
#5
Håkon Strand Aandahl, Erna Von Heimburg, Roland Van den Tillaar
The aim of this study was to examine if kicking with elastic resistance during warm-up could initiate Post-Activation Potentiation (PAP), and thereby positively influence kinematics and performance on subsequent explosive roundhouse kicking. Five woman and eleven men (n=16) with a background in kickboxing (n=10) and/or TaeKwonDo (n=6) performed two warm-up strategies with three subsequent test-kicks 5-8 minutes after a PAP inducing exercise. Kicking performance, defined as roundhouse kicking velocity with the foot, was measured using 3D motion capture (500 Hz) with a 15 marker lower body 3D model...
November 29, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29193056/identification-of-a-novel-fusion-gene-hmga2-egfr-in-glioblastoma
#6
Akiyoshi Komuro, Erna Raja, Caname Iwata, Manabu Soda, Kazunobu Isogaya, Keiko Yuki, Yasushi Ino, Masato Morikawa, Tomoki Todo, Hiroyuki Aburatani, Hiromichi Suzuki, Melissa Ranjit, Atsushi Natsume, Akitake Mukasa, Nobuhito Saito, Hitoshi Okada, Hiroyuki Mano, Kohei Miyazono, Daizo Koinuma
Glioblastoma is one of the most malignant forms of cancer, for which no effective targeted therapy has been found. Although the Cancer Genome Atlas (TCGA) has provided a list of fusion genes in glioblastoma, their role in progression of glioblastoma remains largely unknown. To search for novel fusion genes, we obtained RNA-seq data from TGS-01 human glioma-initiating cells, and identified a novel fusion gene (HMGA2-EGFR), encoding a protein comprising the N-terminal region of the high mobility group AT hook protein 2 (HMGA2) fused to the C-terminal region of epidermal growth factor receptor (EGFR), which retained the transmembrane and kinase domains of the EGFR...
November 29, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29187597/emerging-roles-of-transcriptional-enhancers-in-chromatin-looping-and-promoter-proximal-pausing-of-rna-polymerase-ii
#7
Huan Meng, Blaine Bartholomew
Initiation and regulation of transcription by RNA polymerase II (RNAPII) in eukaryotes relies upon the control elements of promoters and enhancers. Promoters and enhancers share common architectures and functions in similar ways. The prevailing view is functional promoters and enhancers can initiate bidirectional transcription. With the acceleration of recent genome-wide studies of regulated transcription, it has become clear that transcriptional enhancers in mammalian genomes are major sources of pervasive non-coding RNA transcription...
November 29, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29156835/indonesian-herbal-medicine-prevents-hypertension-induced-left-ventricular-hypertrophy-by-diminishing-nadph-oxidase-dependent-oxidative-stress
#8
Erna Sulistyowati, Jong-Hau Hsu, Yuan-Bin Cheng, Fang-Rong Chang, Ying-Fu Chen, Jwu-Lai Yeh
Indonesian herbal medicine Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction (CJID) are known to be efficacious for hypertension. Oxidative stress plays an important role in hypertension-induced left ventricular hypertrophy (H-LVH). This study evaluated whether CJID inhibit cardiac remodeling in spontaneously hypertensive rats (SHRs) through mechanism of oxidative stress-related cardiac-NADPH oxidase (NOXs) pathway: NOX1, NOX2 and NOX4. Forty-weeks-old SHRs and normotensive-WKY rats, were both randomly divided into 2 groups: CJID and control...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29140466/transcription-induced-supercoiling-as-the-driving-force-of-chromatin-loop-extrusion-during-formation-of-tads-in-interphase-chromosomes
#9
Dusan Racko, Fabrizio Benedetti, Julien Dorier, Andrzej Stasiak
Using molecular dynamics simulations, we show here that growing plectonemes resulting from transcription-induced supercoiling have the ability to actively push cohesin rings along chromatin fibres. The pushing direction is such that within each topologically associating domain (TAD) cohesin rings forming handcuffs move from the source of supercoiling, constituted by RNA polymerase with associated DNA topoisomerase TOP1, towards borders of TADs, where supercoiling is released by topoisomerase TOPIIB. Cohesin handcuffs are pushed by continuous flux of supercoiling that is generated by transcription and is then progressively released by action of TOPIIB located at TADs borders...
November 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29140260/vaccinia-virus-natural-infections-in-brazil-the-good-the-bad-and-the-ugly
#10
REVIEW
Jaqueline Silva de Oliveira, Poliana de Oliveira Figueiredo, Galileu Barbosa Costa, Felipe Lopes de Assis, Betânia Paiva Drumond, Flávio Guimarães da Fonseca, Maurício Lacerda Nogueira, Erna Geessien Kroon, Giliane de Souza Trindade
The orthopoxviruses (OPV) comprise several emerging viruses with great importance to human and veterinary medicine, including vaccinia virus (VACV), which causes outbreaks of bovine vaccinia (BV) in South America. Historically, VACV is the most comprehensively studied virus, however, its origin and natural hosts remain unknown. VACV was the primary component of the smallpox vaccine, largely used during the smallpox eradication campaign. After smallpox was declared eradicated, the vaccination that conferred immunity to OPV was discontinued, favoring a new contingent of susceptible individuals to OPV...
November 15, 2017: Viruses
https://www.readbyqxmd.com/read/29138539/patient-reported-benefits-from-patient-organization-magazines-and-internet-based-peer-support-in-m%C3%A3-ni%C3%A3-re-s-disease
#11
Vinaya Manchaiah, Ilmari Pyykkö, Jing Zou, Hilla Levo, Erna Kentala
Objectives: To facilitate self-help, the Finnish Ménière's Federation (FMF) provides various kinds of support to persons with Ménière's disease (MD), which includes patient magazines (PM) and Internet-based peer support (iPS). The current study aimed to evaluate the benefits reported by MD patients in terms of PM and iPS. Method: The study used a cross-sectional survey design with a mixture of structured and open-ended questions administered online. A sample of 185 patients from the FMF membership database provided complete data...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29138457/functional-annotation-of-structural-ncrnas-within-enhancer-rnas-in-the-human-genome-implications-for-human-disease
#12
Chao Ren, Feng Liu, Zhangyi Ouyang, Gaole An, Chenghui Zhao, Jun Shuai, Shuhong Cai, Xiaochen Bo, Wenjie Shu
Enhancer RNAs (eRNAs) are a novel class of non-coding RNA (ncRNA) molecules transcribed from the DNA sequences of enhancer regions. Despite extensive efforts devoted to revealing the potential functions and underlying mechanisms of eRNAs, it remains an open question whether eRNAs are mere transcriptional noise or relevant biologically functional species. Here, we identified a catalogue of eRNAs in a broad range of human cell/tissue types and extended our understanding of eRNAs by demonstrating their multi-omic signatures...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29126241/lactobacillus-backii-and-pediococcus-damnosus-isolated-from-170-year-old-beer-recovered-from-a-shipwreck-lack-the-metabolic-activities-required-to-grow-in-modern-lager-beer
#13
Ilkka Kajala, Jordyn Bergsveinson, Vanessa Friesen, Anna Redekop, Riikka Juvonen, Erna Storgårds, Barry Ziola
In 2010, bottles of beer containing viable bacteria of the common beer-spoilage species Lactobacillus backii and Pediococcus damnosus were recovered from a shipwreck near the Åland Islands, Finland. The 170-year quiescent state maintained by the shipwreck bacteria presented a unique opportunity to study lactic acid bacteria (LAB) evolution vis a vis growth and survival in the beer environment. Three shipwreck bacteria (one L. backii strain and two P. damnosus strains) and modern-day beer-spoilage isolates of the same two species were genome sequenced, characterized for hop iso-α-acid tolerance, and growth in degassed lager and wheat beer...
November 8, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29110518/age-appropriate-preparations-for-children-with-cancer-undergoing-radiotherapy-a-feasibility-study
#14
Jenny Gårdling, Erna Törnqvist, Marie Edwinson Månsson, Inger Kristensson Hallström
The aim of this study was to test age-appropriate information and preparation procedures for children with cancer undergoing radiotherapy (RT) for feasibility and effectiveness in terms of the need for general anesthesia (GA) and anxiety. In a quasi-experimental controlled clinical trial, 17 children aged 3-18 years receiving age-appropriate preparation were compared with 16 children in a control group. Feasibility in terms of recruitment, compliance, and acceptability was assessed. Effectiveness was assessed by the number of children who underwent treatment without GA and their respective fractions and validated instruments measured the children's anxiety and emotional behavior...
January 1, 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29105874/nocturnal-nasal-obstruction-is-frequent-and-reduces-sleep-quality-in-patients-with-obstructive-sleep-apnea
#15
Maria Värendh, Morgan Andersson, Erla Bjørnsdottir, Harald Hrubos-Strøm, Arne Johannisson, Erna S Arnardottir, Thorarinn Gislason, Sigurdur Juliusson
The prevalence and consequences of nasal obstruction in untreated obstructive sleep apnea patients are not known. The study objectives were to investigate the frequency of subjective and objective nasal obstruction in untreated sleep apnea patients and the associations with sleep and quality of life. Patients in the Icelandic Sleep Apnea Cohort were subjected to a type 3 sleep study, answered questionnaires and had their nasal dimensions measured by acoustic rhinometry. In total, 810 patients participated (including 153 females), aged 54...
November 6, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/29104684/effect-of-flunarizine-on-serum-glutamate-levels-and-its-correlation-with-headache-intensity-in-chronic-tension-type-headache-patients
#16
Khairul Putra Surbakti, Hasan Sjahrir, Rosita Juwita-Sembiring, Erna Mutiara
BACKGROUND: Some of the excitatory neurotransmitters including glutamate have been suggested to be involved in headache pathophysiology. To our knowledge, there is a lack of publication about flunarizine efficacy in chronic tension-type headache (CTTH) treatments and the roles of glutamate in CTTH pathophysiology. AIM: This study aimed to investigate the flunarizine effect on serum levels of glutamate and its correlation with headache intensity based on the Numeric Rating Scale for pain (NRS) scores in CTTH patients...
October 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29095959/wanted-dead-or-alive-using-metabarcoding-of-environmental-dna-and-rna-to-distinguish-living-assemblages-for-biosecurity-applications
#17
Xavier Pochon, Anastasija Zaiko, Lauren M Fletcher, Olivier Laroche, Susanna A Wood
High-throughput sequencing metabarcoding studies in marine biosecurity have largely focused on targeting environmental DNA (eDNA). DNA can persist extracellularly in the environment, making discrimination of living organisms difficult. In this study, bilge water samples (i.e., water accumulating on-board a vessel during transit) were collected from 15 small recreational and commercial vessels. eDNA and eRNA molecules were co-extracted and the V4 region of the 18S ribosomal RNA gene targeted for metabarcoding...
2017: PloS One
https://www.readbyqxmd.com/read/29074826/-update-on-recent-progress-in-vitamin-d-research-molecular-basis-of-epigenetic-regulation-by-vitamin-d-via-its-nuclear-receptor
#18
Shigeaki Kato, Kou-Ichi Nishimura, Jin-Ichi Mori
Environment and structure of chromatin underlie epigenetics, and they also facilitate transcriptional regulations by nuclear receptors including VDR. In this short review, the molecular basis of chromatin remodeling and post-translational modifications of histone proteins are illustrated with characterization of their regulators, providing mechanisms for co-regulation of epigenetics and transcription on chromatin. Moreover, the role of enhancer RNA (eRNA), one of the non-coding RNAs, in chromatin configuration is discussed for gene regulation by VDR...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29071078/respiratory-symptoms-are-more-common-among-short-sleepers-independent-of-obesity
#19
Erla Björnsdóttir, Christer Janson, Eva Lindberg, Erna Sif Arnardottir, Bryndís Benediktsdóttir, Judith Garcia-Aymerich, Anne Elie Carsin, Francisco Gómez Real, Kjell Torén, Joachim Heinrich, Dennis Nowak, José Luis Sánchez-Ramos, Pascal Demoly, Sandra Dorado Arenas, Ramon Coloma Navarro, Vivi Schlünssen, Chantal Raherison, Debbie L Jarvis, Thorarinn Gislason
INTRODUCTION: Sleep length has been associated with obesity and various adverse health outcomes. The possible association of sleep length and respiratory symptoms has not been previously described. The aim of this study was to investigate the association between sleep length and respiratory symptoms and whether such an association existed independent of obesity. METHODS: This is a multicentre, cross-sectional, population-based study performed in 23 centres in 10 different countries...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29053440/association-of-the-hla-b-alleles-with-carbamazepine-induced-stevens-johnson-syndrome-toxic-epidermal-necrolysis-in-the-javanese-and-sundanese-population-of-indonesia-the-important-role-of-the-hla-b75-serotype
#20
Rika Yuliwulandari, Erna Kristin, Kinasih Prayuni, Qomariyah Sachrowardi, Franciscus D Suyatna, Sri Linuwih Menaldi, Nuanjun Wichukchinda, Surakameth Mahasirimongkol, Larisa H Cavallari
Carbamazepine (CBZ) is a common cause of life-threatening cutaneous adverse drug reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Previous studies have reported a strong association between the HLA genotype and CBZ-induced SJS/TEN. We investigated the association between the HLA genotype and CBZ-induced SJS/TEN in Javanese and Sundanese patients in Indonesia. Nine unrelated patients with CBZ-induced SJS/TEN and 236 healthy Javanese and Sundanese controls were genotyped for HLA-B and their allele frequencies were compared...
October 20, 2017: Pharmacogenomics
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