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https://www.readbyqxmd.com/read/28985501/intragenic-enhancers-attenuate-host-gene-expression
#1
Senthilkumar Cinghu, Pengyi Yang, Justin P Kosak, Amanda E Conway, Dhirendra Kumar, Andrew J Oldfield, Karen Adelman, Raja Jothi
Eukaryotic gene transcription is regulated at many steps, including RNA polymerase II (Pol II) recruitment, transcription initiation, promoter-proximal Pol II pause release, and transcription termination; however, mechanisms regulating transcription during productive elongation remain poorly understood. Enhancers, which activate gene transcription, themselves undergo Pol II-mediated transcription, but our understanding of enhancer transcription and enhancer RNAs (eRNAs) remains incomplete. Here we show that transcription at intragenic enhancers interferes with and attenuates host gene transcription during productive elongation...
October 5, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28976263/physiological-and-perceptual-strain-of-firefighters-during-graded-exercise-to-exhaustion-at-40-%C3%A2-c-and-10-%C3%A2-c
#2
Erna von Heimburg, Mariann Sandsund, Tone Pedersen Rangul, Randi Eidsmo Reinertsen
PURPOSE: To study whether perceptual identification should be included as a measure to evaluate physiological stress. METHODS: Physiological variables; oxygen uptake (VO2), ventilation, heart rate (HR), blood lactate concentration, rectal temperature (Trec) and mean skin temperature (Tskin), perceptual variables; rate of perceived exertion (RPE), thermal sensation (TS) and time to exhaustion were measured at submaximal and maximal intensities during graded exercise on a treadmill to exhaustion in 12 firefighters wearing protective clothing and extra mass at 40 °C and 10 °C...
October 4, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28956317/the-role-of-nuclear-medicine-in-assessments-of-cardiac-dyssynchrony
#3
Masanao Naya, Osamu Manabe, Kazuhiro Koyanagawa, Nagara Tamaki
Radionuclide imaging has an advantage for quantitative analyses of the tracer concentration and its temporal changes. Myocardial perfusion and function have been adapted for synchrony analyses. Extracted parameters have been demonstrated to measure ventricular synchrony and even to predict CRT outcomes. ERNA has the advantages of higher temporal resolution, greater reproducibility, and the volumetric analysis of both ventricles that can be applied for analyses of intraventricular synchrony and interventricular synchrony...
September 27, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28954173/antidiarrheal-activity-of-extracts-from-maytenus-gonoclada-and-inhibition-of-dengue-virus-by-lupeol
#4
Fernando C Silva, Vanessa G Rodrigues, Lucienir P Duarte, Ivana S Lula, Ruben D Sinisterra, Sidney A Vieira-Filho, Rodrigo A L Rodrigues, Erna G Kroon, Patrícia L Oliveira, Luiz M Farias, Paula P Magalhães, Grácia D F Silva
Diarrhea is an infectious disease caused by bacterial, virus, or protozoan, and dengue is caused by virus, included among the neglected diseases in several underdeveloped and developing countries, with an urgent demand for new drugs. Considering the antidiarrheal potential of species of Maytenus genus, a phytochemical investigation followed by antibacterial activity test with extracts of branches and heartwood and bark of roots from Maytenus gonoclada were conducted. Moreover, due the frequency of isolation of lupeol from Maytenus genus the antiviral activity against Dengue virus and cytotoxicity of lupeol and its complex with β-cyclodextrins were also tested...
July 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28936977/the-current-research-status-of-enhancer-rnas
#5
Xiao Cheng, Qiong Yang, Zhen-Dong Tan, Ya Tan, Hongzhou Pu, Xue Zhao, Shun-Hua Zhang, Li Zhu
Enhancers are key cis-acting gene regulatory elements in eukaryotes, which can effectively promote the expression of target genes. Emerging evidence showed that enhancers in activation state could be transcribed to enhancer RNAs (eRNAs), the processes of which are regulated by various signaling systems and actions of signal-dependent transcription factors. Compared with the other transcripts (e.g. lncRNA, mRNA), eRNAs have shorter sequences, lower stability, and higher tissue specificity. eRNAs play roles in the initiation or stabilization of enhancer-promoter looping, and promote the expression of target genes...
September 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28934533/carotid-artery-wall-thickness-in-obese-and-nonobese-adults-with-obstructive-sleep-apnea-before-and-following-positive-airway-pressure-treatment
#6
Jinyoung Kim, Emile R Mohler, Brendan T Keenan, David Maislin, Erna Sif Arnardottir, Thorarinn Gislason, Bryndis Benediktsdottir, Sigrun Gudmundsdottir, Andrea Sifferman, Bethany Staley, Frances M Pack, Greg Maislin, Julio A Chirinos, Raymond R Townsend, Allan I Pack, Samuel T Kuna
Study objectives: Debate persists as to whether obstructive sleep apnea (OSA) is an independent risk factor for atherosclerosis. The purpose of this study was to compare carotid intima-media thickness (IMT), an early sign of atherosclerosis, in obese and nonobese adults with OSA before and following positive airway pressure (PAP) treatment. Methods: A total of 206 adults newly diagnosed with OSA with an apnea-hypopnea index (AHI) of 15-75 events/hour and 53 controls with AHI <10 were studied...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28919731/sensitization-to-aspergillus-fumigatus-as-a-risk-factor-for-bronchiectasis-in-copd
#7
Stephanie Everaerts, Katrien Lagrou, Adriana Dubbeldam, Natalie Lorent, Kristina Vermeersch, Erna Van Hoeyveld, Xavier Bossuyt, Lieven J Dupont, Bart M Vanaudenaerde, Wim Janssens
BACKGROUND: Bronchiectasis-chronic obstructive pulmonary disease (COPD) overlap presents a possible clinical phenotype of COPD, but it is unclear why it develops in a subset of patients. We hypothesized that sensitization to Aspergillus fumigatus (A fum) is associated with bronchiectasis in COPD and occurs more frequently in vitamin D-deficient patients. METHODS: This observational study investigated sensitization to A fum in an outpatient clinical cohort of 300 COPD patients and 50 (ex-) smoking controls...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28912772/an-anthropocentric-view-of-the-virosphere-host-relationship
#8
Rodrigo A L Rodrigues, Ana C Dos S P Andrade, Paulo V de M Boratto, Giliane de S Trindade, Erna G Kroon, Jônatas S Abrahão
For over a century, viruses have been known as the most abundant and diverse group of organisms on Earth, forming a virosphere. Based on extensive meta-analyses, we present, for the first time, a wide and complete overview of virus-host network, covering all known viral species. Our data indicate that most of known viral species, regardless of their genomic category, have an intriguingly narrow host range, infecting only 1 or 2 host species. Our data also show that the known virosphere has expanded based on viruses of human interest, related to economical, medical or biotechnological activities...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28891741/erna-binding-produces-tailored-cbp-activity-profiles-to-regulate-gene-expression
#9
Daniel A Bose, Shelley L Berger
Enhancers are cis- regulatory genetic elements crucial for controlling temporal and cell-type specific patterns of gene expression. Active enhancers generate bi-directional non-coding RNA transcripts called enhancer RNAs (eRNAs). eRNAs are important for stimulating gene expression, but precise mechanisms for this ability remain unclear. Here we highlight recent findings that demonstrate a direct interaction between RNAs and the transcriptional co-activator Creb-binding protein (CBP). Notably, RNA binding could stimulate the core histone acetyltransferase activity of the enzyme, observable in cells as a link between eRNA production, CBP-dependent histone acetylation and expression of genes regulated by specific enhancers...
September 11, 2017: RNA Biology
https://www.readbyqxmd.com/read/28884215/effect-of-smoking-cessation-on-quantitative-computed-tomography-in-smokers-at-risk-in-a-lung-cancer-screening-population
#10
Bertram J Jobst, Oliver Weinheimer, Mila Trauth, Nikolaus Becker, Erna Motsch, Marie-Luise Groß, Jan Tremper, Stefan Delorme, Anke Eigentopf, Monika Eichinger, Hans-Ulrich Kauczor, Mark O Wielpütz
OBJECTIVE: To longitudinally evaluate effects of smoking cessation on quantitative CT in a lung cancer screening cohort of heavy smokers over 4 years. METHODS: After 4 years, low-dose chest CT was available for 314 long-term ex-smokers (ES), 404 continuous smokers (CS) and 39 recent quitters (RQ) who quitted smoking within 2 years after baseline CT. CT acquired at baseline and after 3 and 4 years was subjected to well-evaluated densitometry software, computing mean lung density (MLD) and 15th percentile of the lung density histogram (15TH)...
September 7, 2017: European Radiology
https://www.readbyqxmd.com/read/28882653/behavioural-responses-of-two-spotted-spider-mites-induced-by-predator-borne-and-prey-borne-cues
#11
Enikő Gyuris, Erna Szép, Jenő Kontschán, Attila Hettyey, Zoltán Tóth
Applying predatory mites as biological control agents is a well established method against spider mites which are major pests worldwide. Although antipredator responses can influence the outcome of predator-prey interactions, we have limited information about what cues spider mites use to adjust their behavioural antipredator responses. We experimentally exposed two-spotted spider mites (Tetranychus urticae) to different predator-borne cues (using a specialist predator, Phytoseiulus persimilis, or a generalist predator, Amblyseius swirskii), conspecific prey-borne cues, or both, and measured locomotion and egg-laying activity...
November 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28878069/filling-gaps-about-mimivirus-entry-uncoating-and-morphogenesis
#12
Ana Cláudia Dos Santos Pereira Andrade, Rodrigo Araújo Lima Rodrigues, Graziele Pereira Oliveira, Kétyllen Reis Andrade, Cláudio Antônio Bonjardim, Bernard La Scola, Erna Geessien Kroon, Jônatas Santos Abrahão
Since the discovery of mimivirus, its unusual structural and genomic features have raised great interest in the study of its biology; however, many aspects concerning its replication cycle remain uncertain. In this study, extensive analyses of electron microscope images, as well as biological assays, shed light on unclear points concerning the mimivirus replication cycle. Here, we demonstrate that cytochalasin treatment, a phagocytosis inhibitor, impacts negatively on the incorporation of mimivirus particles by Acanthamoeba castellanii, causing a negative effect on viral growth in amoebae monolayers...
September 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28877670/indoleamine-2-3-dioxygenase-ido-increases-during-renal-fibrogenesis-and-its-inhibition-potentiates-tgf-%C3%AE-1-induced-epithelial-to-mesenchymal-transition
#13
Luiz Henrique Gomes Matheus, Gislene Mendes Simão, Taíssa Altieri Amaral, Rodrigo Barbosa Oliveira Brito, Camila Soares Malta, Yves Silva Teles Matos, Alexandre Chagas Santana, Gabriela Gomes Cardoso Rodrigues, Maria Clara Albejante, Erna Elisabeth Bach, Maria Aparecida Dalboni, Cleber Pinto Camacho, Humberto Dellê
BACKGROUND: Indoleamine 2, 3-dioxygenase (IDO) is an immunomodulatory molecule that has been implicated in several biological processes. Although IDO has been linked with some renal diseases, its role in renal fibrosis is still unclear. Because IDO may be modulated by TGF-β1, a potent fibrogenic molecule, we hypothesized that IDO could be involved in renal fibrosis, especially acting in the TGF-β1-induced tubular epithelial-mesenchymal transition (EMT). We analyzed the IDO expression and activity in a model of renal fibrogenesis, and the effect of the IDO inhibitor 1-methyl-tryptophan (MT) on TGF-β1-induced EMT using tubular cell culture...
September 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28877572/safety-efficacy-and-physicochemical-characterization-of-tinospora-crispa-ointment-a-community-based-formulation-against-pediculus-humanus-capitis
#14
Gerwin Louis Tapan Dela Torre, Kerstin Mariae Gonzales Ponsaran, Angelica Louise Dela Peña de Guzman, Richelle Ann Mallapre Manalo, Erna Custodio Arollado
The high prevalence of pediculosis capitis, commonly known as head lice (Pediculus humanus capitis) infestation, has led to the preparation of a community-based pediculicidal ointment, which is made of common household items and the extract of Tinospora crispa stem. The present study aimed to evaluate the safety, efficacy, and physicochemical characteristics of the T. crispa pediculicidal ointment. The physicochemical properties of the ointment were characterized, and safety was determined using acute dermal irritation test (OECD 404), while the efficacy was assessed using an in vitro pediculicidal assay...
August 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28875581/european-guideline-for-the-diagnosis-and-treatment-of-insomnia
#15
REVIEW
Dieter Riemann, Chiara Baglioni, Claudio Bassetti, Bjørn Bjorvatn, Leja Dolenc Groselj, Jason G Ellis, Colin A Espie, Diego Garcia-Borreguero, Michaela Gjerstad, Marta Gonçalves, Elisabeth Hertenstein, Markus Jansson-Fröjmark, Poul J Jennum, Damien Leger, Christoph Nissen, Liborio Parrino, Tiina Paunio, Dirk Pevernagie, Johan Verbraecken, Hans-Günter Weeß, Adam Wichniak, Irina Zavalko, Erna S Arnardottir, Oana-Claudia Deleanu, Barbara Strazisar, Marielle Zoetmulder, Kai Spiegelhalder
This European guideline for the diagnosis and treatment of insomnia was developed by a task force of the European Sleep Research Society, with the aim of providing clinical recommendations for the management of adult patients with insomnia. The guideline is based on a systematic review of relevant meta-analyses published till June 2016. The target audience for this guideline includes all clinicians involved in the management of insomnia, and the target patient population includes adults with chronic insomnia disorder...
September 5, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28869610/mutations-in-actrt1-and-its-enhancer-rna-elements-lead-to-aberrant-activation-of-hedgehog-signaling-in-inherited-and-sporadic-basal-cell-carcinomas
#16
Elodie Bal, Hyun-Sook Park, Zakia Belaid-Choucair, Hülya Kayserili, Magali Naville, Marine Madrange, Elena Chiticariu, Smail Hadj-Rabia, Nicolas Cagnard, Francois Kuonen, Daniel Bachmann, Marcel Huber, Cindy Le Gall, Francine Côté, Sylvain Hanein, Rasim Özgür Rosti, Ayca Dilruba Aslanger, Quinten Waisfisz, Christine Bodemer, Olivier Hermine, Fanny Morice-Picard, Bruno Labeille, Frédéric Caux, Juliette Mazereeuw-Hautier, Nicole Philip, Nicolas Levy, Alain Taieb, Marie-Françoise Avril, Denis J Headon, Gabor Gyapay, Thierry Magnaldo, Sylvie Fraitag, Hugues Roest Crollius, Pierre Vabres, Daniel Hohl, Arnold Munnich, Asma Smahi
Basal cell carcinoma (BCC), the most common human cancer, results from aberrant activation of the Hedgehog signaling pathway. Although most cases of BCC are sporadic, some forms are inherited, such as Bazex-Dupré-Christol syndrome (BDCS)-a cancer-prone genodermatosis with an X-linked, dominant inheritance pattern. We have identified mutations in the ACTRT1 gene, which encodes actin-related protein T1 (ARP-T1), in two of the six families with BDCS that were examined in this study. High-throughput sequencing in the four remaining families identified germline mutations in noncoding sequences surrounding ACTRT1...
October 2017: Nature Medicine
https://www.readbyqxmd.com/read/28865760/inhibition-of-lysozyme-amyloidogenesis-by-phospholipids-focus-on-long-chain-dimyristoylphosphocholine
#17
Slavomira Ponikova, Jana Kubackova, Zuzana Bednarikova, Jozef Marek, Erna Demjen, Andrea Antosova, Andrey Musatov, Zuzana Gazova
BACKGROUND: Protein amyloid aggregation is an important pathological feature of a group of different degenerative human diseases called amyloidosis. We tested effect of two phospholipids, 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC) on amyloid aggregation of hen egg white (HEW) lysozyme in vitro. METHODS: Effect of phospholipids was investigated using spectroscopic techniques (fluorescence and CD spectroscopy), atomic force microscopy and image analysis...
November 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28854264/oral-glucose-tolerance-test-predicts-increased-carotid-plaque-burden-in-patients-with-acute-coronary-syndrome
#18
Thorarinn A Bjarnason, Steinar O Hafthorsson, Linda B Kristinsdottir, Erna S Oskarsdottir, Thor Aspelund, Sigurdur Sigurdsson, Vilmundur Gudnason, Karl Andersen
BACKGROUND: Type 2 diabetes and prediabetes are established risk factors for atherosclerosis. The aim of this study was to evaluate the atherosclerotic plaque burden in the carotid arteries of patients with acute coronary syndrome according to their glycemic status. METHODS: Patients with acute coronary syndrome and no previous history of type 2 diabetes were consecutively included in the study. Glucose metabolism was evaluated with fasting glucose in plasma, HbA1c and a standard two-hour oral glucose tolerance test...
2017: PloS One
https://www.readbyqxmd.com/read/28844942/circadian-time-effects-on-nb-uvb-induced-erythema-in-human-skin-in-vivo
#19
Veera Nikkola, Mari Grönroos, Riitta Huotari-Orava, Hannu Kautiainen, Lasse Ylianttila, Toni Karppinen, Timo Partonen, Erna Snellman
No abstract text is available yet for this article.
August 24, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28835205/prehypertension-and-psychosocial-risk-factors-among-university-students-in-asean-countries
#20
Karl Peltzer, Supa Pengpid, Vanphanom Sychareun, Alice Joan G Ferrer, Wah Yun Low, Thang Nguyen Huu, Hla Hla Win, Erna Rochmawati, Niruwan Turnbull
BACKGROUND: Existing evidence suggests that the cardiovascular morbidities are increasing among pre-hypertensive individuals compared to normal. The aim of this study was to evaluate the prevalence of prehypertension, hypertension and to identify psychosocial risk factors for prehypertension among university students in Association of South East Asian Nation (ASEAN) countries. METHODS: Based on a cross-sectional survey, the total sample included 4649 undergraduate university students (females = 65...
August 23, 2017: BMC Cardiovascular Disorders
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