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https://www.readbyqxmd.com/read/27450223/assessment-of-the-diagnostic-performance-of-the-ids-isys-tests-for-toxo-igg-toxo-igm-and-avidity
#1
Pauline Levigne, François Peyron, Martine Wallon
When acquired during pregnancy toxoplasmosis can have devastating consequences on the fetus. As maternal infection is in the majority of cases subclinical, the diagnosis of toxoplasmosis relies on serological tests for the detection of IgG, IGM and the mesure of IgG avidity. We evaluated the performance of IDS-iSYS a new automatized instrument based on chemiluminescence for the diagnosis of the disease. Our study was based on non-selected samples received in our laboratory either for the determination of serological status or for distinguishing acute from chronic infection...
October 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27067006/generation-of-catalytic-antibodies-is-an-intrinsic-property-of-an-individual-s-immune-system-a-study-on-a-large-cohort-of-renal-transplant-patients
#2
Ankit Mahendra, Ivan Peyron, Olivier Thaunat, Cécile Dollinger, Laurent Gilardin, Meenu Sharma, Bharath Wootla, Desirazu N Rao, Séverine Padiolleau-Lefevre, Didier Boquet, Abhijit More, Navin Varadarajan, Srini V Kaveri, Christophe Legendre, Sébastien Lacroix-Desmazes
Renal transplant is the treatment of choice for patients with terminal end-stage renal disease. We have previously identified low levels of catalytic IgG as a potential prognosis marker for chronic allograft rejection. The origin and physiopathological relevance of catalytic Abs is not well understood, owing to the fact that catalytic Abs have been studied in relatively small cohorts of patients with rare diseases and/or without systematic follow-up. In the current study, we have followed the evolution of the levels of catalytic IgG in a large cohort of renal transplant patients over a 2-y period...
May 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/26986117/observational-study-of-a-french-and-belgian-multicenter-cohort-of-23-patients-diagnosed-in-adulthood-with-mevalonate-kinase-deficiency
#3
MULTICENTER STUDY
Cécile-Audrey Durel, Achille Aouba, Boris Bienvenu, Samuel Deshayes, Brigitte Coppéré, Bruno Gombert, Cécile Acquaviva-Bourdain, Eric Hachulla, Frédéric Lecomte, Isabelle Touitou, Jacques Ninet, Jean-Baptiste Philit, Laurent Messer, Marc Brouillard, Marie-Hélène Girard-Madoux, Michel Moutschen, Nadia Raison-Peyron, Pascal Hutin, Pierre Duffau, Pierre Trolliet, Pierre-Yves Hatron, Philippe Heudier, Ramiro Cevallos, Thierry Lequerré, Valentine Brousse, Vincent Lesire, Sylvain Audia, Delphine Maucort-Boulch, Laurence Cuisset, Arnaud Hot
The aim of this study was to describe the clinical and biological features of Mevalonate kinase deficiency (MKD) in patients diagnosed in adulthood. This is a French and Belgian observational retrospective study from 2000 to 2014. To constitute the cohort, we cross-check the genetic and biochemical databases. The clinical, enzymatic, and genetic data were gathered from medical records. Twenty-three patients were analyzed. The mean age at diagnosis was 40 years, with a mean age at onset of symptoms of 3 years...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26785157/functional-brain-imaging-what-has-it-brought-to-our-understanding-of-neuropathic-pain-a-special-focus-on-allodynic-pain-mechanisms
#4
REVIEW
Roland Peyron
Brain responses to nociception are well identified. The same is not true for allodynic pain, a strong painful sensation in response to touch or innocuous cold stimuli that may be experienced by patients with neuropathic pain. Brain (or spinal cord) reorganization that may explain this paradoxical perception still remains largely unknown. Allodynic pain is associated with abnormally increased activity in SII and in the anterior insular cortex, contralateral and/or ipsilateral to allodynia. Because a bilateral increase in activity has been repeatedly reported in these areas in nociceptive conditions, the observed activation during allodynia can explain that a physiologically nonpainful stimulus could be perceived by the damaged nervous system as a painful one...
February 2016: Pain
https://www.readbyqxmd.com/read/26529015/the-saccharomyces-boulardii-cncm-i-745-strain-shows-protective-effects-against-the-b-anthracis-lt-toxin
#5
Rodolphe Pontier-Bres, Patrick Rampal, Jean-François Peyron, Patrick Munro, Emmanuel Lemichez, Dorota Czerucka
The probiotic yeast Saccharomyces boulardii (S. boulardii) has been prescribed for the prophylaxis and treatment of several infectious diarrheal diseases. Gastrointestinal anthrax causes fatal systemic disease. In the present study, we investigated the protective effects conferred by Saccharomyces boulardii CNCM I-745 strain on polarized T84 columnar epithelial cells intoxicated by the lethal toxin (LT) of Bacillus anthracis. Exposure of polarized T84 cells to LT affected cell monolayer integrity, modified the morphology of tight junctions and induced the formation of actin stress fibers...
November 2015: Toxins
https://www.readbyqxmd.com/read/26085297/chronic-intermittent-hypoxia-induces-chronic-low-grade-neuroinflammation-in-the-dorsal-hippocampus-of-mice
#6
Emilie Sapin, Christelle Peyron, Frédéric Roche, Nadine Gay, Carole Carcenac, Marc Savasta, Patrick Levy, Maurice Dematteis
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) induces cognitive impairment that involves intermittent hypoxia (IH). Because OSA is recognized as a low-grade systemic inflammatory disease and only some patients develop cognitive deficits, we investigated whether IH-related brain consequences shared similar pathophysiology and required additional factors such as systemic inflammation to develop. DESIGN: Nine-week-old male C57BL/6J mice were exposed to 1 day, 6 or 24 w of IH (alternating 21-5% FiO2 every 30 sec, 8 h/day) or normoxia...
October 1, 2015: Sleep
https://www.readbyqxmd.com/read/25764140/improving-heart-healthy-lifestyles-among-participants-in-a-salud-para-su-coraz%C3%A3-n-promotores-model-the-mexican-pilot-study-2009-2012
#7
Héctor Balcázar, Ana Cecilia Fernández-Gaxiola, Ana Bertha Pérez-Lizaur, Rosa Adriana Peyron, Carma Ayala
INTRODUCTION: In Mexico, cardiovascular disease and its risk factors are growing problems and major public health concerns. The objective of this study was to implement cardiovascular health promotion and disease prevention activities of the Salud para su Corazón model in a high-risk, impoverished, urban community in Mexico City. METHODS: We used a pretest-posttest (baseline to 12-week follow-up) design without a control group. Material from Salud para su Corazón was validated and delivered by promotores (community health workers) to community members from 6 geographic areas...
2015: Preventing Chronic Disease
https://www.readbyqxmd.com/read/25291481/contact-sensitization-to-modern-dressings-a-multicentre-study-on-354-patients-with-chronic-leg-ulcers
#8
MULTICENTER STUDY
Aude Valois, Julie Waton, Martine Avenel-Audran, François Truchetet, Evelyne Collet, Nadia Raison-Peyron, Jean Francois Cuny, Benjamin Bethune, Jean Luc Schmutz, Annick Barbaud
BACKGROUND: Modern dressings (MDs) may have a low sensitization rate, but there is a lack of prospective studies in patients with chronic leg ulcers (CLUs) to evaluate this. OBJECTIVES: To determine the rate of sensitization (contact allergy) to MDs and substances present in dressings. PATIENTS AND METHODS: A prospective multicentre study was carried out in patients with CLUs at five French dermatology departments; patch tests were performed with the European baseline series and with an additional 27 individual allergens and 10 MDs...
February 2015: Contact Dermatitis
https://www.readbyqxmd.com/read/25118595/saccharomyces-boulardii-modifies-salmonella-typhimurium-traffic-and-host-immune-responses-along-the-intestinal-tract
#9
Rodolphe Pontier-Bres, Patrick Munro, Laurent Boyer, Rodolphe Anty, Véronique Imbert, Chloé Terciolo, Fréderic André, Patrick Rampal, Emmanuel Lemichez, Jean-François Peyron, Dorota Czerucka
Salmonella enterica serovar Typhimurium (ST) is an enteropathogenic Gram-negative bacterium that causes infection following oral ingestion. ST spreads rapidly along the gastrointestinal tract (GIT) and invades the intestinal epithelium to ultimately reach internal body organs. The probiotic yeast Saccharomyces boulardii BIOCODEX (S.b-B) is prescribed for prophylaxis of diarrheal infectious diseases. We previously showed that S.b-B prevents weight loss in ST-infected mice and significantly decreases bacterial translocation to the spleen and liver...
2014: PloS One
https://www.readbyqxmd.com/read/24969045/surgical-management-of-liver-hydatid-disease-subadventitial-cystectomy-versus-resection-of-the-protruding-dome
#10
COMPARATIVE STUDY
Kayvan Mohkam, Leila Belkhir, Martine Wallon, Benjamin Darnis, François Peyron, Christian Ducerf, Jean-François Gigot, Jean-Yves Mabrut
BACKGROUND: The aim of this study was to compare postoperative outcome and long-term results after management of liver hydatid cysts (LHC) by subadventitial cystectomy (SC) and resection of the protruding dome (RPD) in two tertiary liver surgery centers. METHODS: Medical records of 52 patients who underwent SC in one center, and 27 patients who underwent RPD in another center between 1991 and 2011 were reviewed. Patients underwent long-term follow-up, including serology tests and morphological examinations...
August 2014: World Journal of Surgery
https://www.readbyqxmd.com/read/24489475/pain-related-mood-influences-pain-perception-differently-in-fibromyalgia-and-multiple-sclerosis
#11
Céline Borg, Catherine Padovan, Catherine Thomas-Antérion, Céline Chanial, Anaïs Sanchez, Marion Godot, Roland Peyron, Odile De Parisot, Bernard Laurent
In patients, the perception of pain intensity may be influenced by the subjective representation of their disease. Although both multiple sclerosis (MS) and fibromyalgia (FM) possibly include chronic pain, they seem to elicit different disease representations because of the difference in their respective etiology, the former presenting evidence of underlying lesions as opposed to the latter. Thus, we investigated whether patients with FM differed from patients with MS with respect to their perception of "own" pain as well as others' pain...
2014: Journal of Pain Research
https://www.readbyqxmd.com/read/23587746/solar-urticaria-a-time-extended-retrospective-series-of-61-patients-and-review-of-literature
#12
REVIEW
Aurélie Du-Thanh, Anca Debu, Pauline Lalheve, Bernard Guillot, Olivier Dereure, Jean-Louis Peyron
BACKGROUND: Solar urticaria is a rare, disabling, chronic disease. Few large series are available. OBJECTIVE: To report the epidemiological, clinical, phototesting, treatment and patient outcome data of a large series. METHODS: Data from 61 patients' files were retrospectively retrieved in a tertiary referral centre. RESULTS: 43 women and 18 men were included (mean age at first symptoms: 34 y). 3 patients had a medical history of chronic urticaria and 29% of atopy...
April 1, 2013: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/23482562/a-novel-p-1b-type-mn2-transporting-atpase-is-required-for-secreted-protein-metallation-in-mycobacteria
#13
Teresita Padilla-Benavides, Jarukit E Long, Daniel Raimunda, Christopher M Sassetti, José M Argüello
Transition metals are central for bacterial virulence and host defense. P(1B)-ATPases are responsible for cytoplasmic metal efflux and play roles either in limiting cytosolic metal concentrations or in the maturation of secreted metalloproteins. The P(1B)-ATPase, CtpC, is required for Mycobacterium tuberculosis survival in a mouse model (Sassetti, C. M., and Rubin, E. J. (2003) Genetic requirements for mycobacterial survival during infection. Proc. Natl. Acad. Sci. U.S.A. 100, 12989-12994). CtpC prevents Zn(2+) toxicity, suggesting a role in Zn(2+) export from the cytosol (Botella, H...
April 19, 2013: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/23428138/-congenital-toxoplasmosis-long-term-ophthalmologic-follow-up-praised-by-patients
#14
L Beraud, M Rabilloud, J Fleury, M Wallon, F Peyron
INTRODUCTION: Ocular lesions of congenital toxoplasmosis may occur and relapse unpredictably even a long time after birth. There is no consensus concerning the necessity or timing of ophthalmologic follow-up for these patients. We surveyed adults with congenital toxoplasmosis followed regularly since birth, in order to learn their perceptions of this follow-up. The goal of this study was to provide doctors with patient-reported information on how they perceived the long-term monitoring of their disease...
June 2013: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/23207286/antibody-mediated-catalysis-induction-and-therapeutic-relevance
#15
REVIEW
Ankit Mahendra, Meenu Sharma, Desirazu N Rao, Ivan Peyron, Cyril Planchais, Jordan D Dimitrov, Srini V Kaveri, Sébastien Lacroix-Desmazes
Abzymes are immunoglobulins endowed with enzymatic activities. The catalytic activity of an abzyme resides in the variable domain of the antibody, which is constituted by the close spatial arrangement of amino acid residues involved in catalysis. The origin of abzymes is conferred by the innate diversity of the immunoglobulin gene repertoire. Under deregulated immune conditions, as in autoimmune diseases, the generation of abzymes to self-antigens could be deleterious. Technical advancement in the ability to generate monoclonal antibodies has been exploited in the generation of abzymes with defined specificities and activities...
April 2013: Autoimmunity Reviews
https://www.readbyqxmd.com/read/23159816/placental-site-and-epithelioid-trophoblastic-tumours-diagnostic-pitfalls
#16
Amandine Moutte, Muriel Doret, Touria Hajri, Noemie Peyron, Florence Chateau, Jerome Massardier, Pierre Duvillard, Daniel Raudrant, François Golfier
OBJECTIVE: To describe the clinical and histological pitfalls in the diagnosis of placental site trophoblastic tumours (PSTT) and epithelioid trophoblastic tumours (ETT), two rare types of gestational trophoblastic neoplasia (GTN). METHODS: This retrospective, observational, study was carried out in the French Trophoblastic Disease Reference Centre, Lyon, between 2000 and 2011. Due to the many similarities in the diagnosis, treatment and prognosis of PSTT and ETT, these two types of tumour were investigated together...
March 2013: Gynecologic Oncology
https://www.readbyqxmd.com/read/23034016/gastric-carcinoma-associated-with-menetrier-s-like-disease-in-a-west-highland-white-terrier
#17
P Lecoindre, M Bystricka, M Chevallier, C Peyron
A seven-year-old West Highland white terrier was presented for chronic vomiting associated with mild regenerative anaemia and hypoalbuminaemia. Further examination showed a giant polypoid cerebriform mass located in the lesser curvature of the stomach. Partial gastrectomy was performed and histology was consistent with hypertrophic gastritis with typical features of Ménétrier's disease. Five years after surgery, the dog was re-examined for recurrence of vomiting episodes. Endoscopy showed ulceration of the lesser curvature of the stomach and histological analysis revealed a poorly differentiated superficial gastric carcinoma surrounded by hypertrophic gastritis...
December 2012: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/22922460/improved-dexterity-after-chronic-electrical-stimulation-of-the-motor-cortex-for-central-pain-a-special-relevance-for-thalamic-syndrome
#18
RANDOMIZED CONTROLLED TRIAL
Christophe Nuti, François Vassal, Patrick Mertens, Jean-Jacques Lemaire, Michel Magnin, Roland Peyron
OBJECTIVES: To demonstrate that motor cortex stimulation (MCS) could improve motor function in patients with neuropathic pain. METHODS: In this prospective clinical study of 38 patients referred for MCS as treatment for their neuropathic pain, we collected any declaration of improvement in motor performance that could be attributed to MCS. RESULTS: Ten patients (26%) declared a benefit in their motor function. Eight presented objective evidence of recovered dexterity for rapid alternating movements...
2012: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/22809016/a-recombinant-%C3%AF-gliadin-like-d-type-glutenin-and-an-%C3%AE-gliadin-from-wheat-triticum-aestivum-two-immunoglobulin-e-binding-proteins-useful-for-the-diagnosis-of-wheat-dependent-allergies
#19
Hamza Mameri, Isabelle Bouchez, Catherine Pecquet, Nadia Raison-Peyron, Dominique Choudat, Habib Chabane, Stephane Kerre, Sandra Denery-Papini, Yann Gohon, Pierre Briozzo, Michel Laurière, Jacques Snégaroff
Among the wheat prolamins, D-type glutenins display a highly repetitive sequence similar to ω-gliadins, but they contain a cysteine, that allows them to be included in the gluten macropolymers. An ω-gliadin-like D-type glutenin, an α-gliadin, and an ω5-gliadin-like D-type glutenin were obtained as recombinant proteins and compared using synchrotron radiation circular dichroism. This technique evidenced the strong thermostability of the ω5-gliadin-like protein. The IgE reactivity of recombinant proteins was evaluated using 45 sera from wheat-allergic patients...
August 15, 2012: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/22654105/nuclear-factor-%C3%AE%C2%BAb-regulates-%C3%AE-app-and-%C3%AE-and-%C3%AE-secretases-differently-at-physiological-and-supraphysiological-a%C3%AE-concentrations
#20
Linda Chami, Virginie Buggia-Prévot, Eric Duplan, Dolores Del Prete, Dolores Delprete, Mounia Chami, Jean-François Peyron, Frédéric Checler
Anatomical lesions in Alzheimer disease-affected brains mainly consist of senile plaques, inflammation stigmata, and oxidative stress. The nuclear factor-κB (NF-κB) is a stress-activated transcription factor that is activated around senile plaques. We have assessed whether NF-κB could be differentially regulated at physiological or supraphysiological levels of amyloid β (Aβ) peptides. Under these experimental conditions, we delineated the putative NF-κB-dependent modulation of all cellular participants in Aβ production, namely its precursor βAPP (β-amyloid precursor protein) and the β- and γ-secretases, the two enzymatic machines involved in Aβ genesis...
July 13, 2012: Journal of Biological Chemistry
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