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https://www.readbyqxmd.com/read/28940143/narcolepsy-type-1-as-an-autoimmune-disorder-evidence-and-implications-for-pharmacological-treatment
#1
Lucie Barateau, Roland Liblau, Christelle Peyron, Yves Dauvilliers
Narcolepsy type 1 (NT1) is a rare sleep disorder caused by the very specific loss of hypothalamic hypocretin (Hcrt)/orexin neurons. The exact underlying process leading to this destruction is yet unknown, but indirect evidence strongly supports an autoimmune origin. The association with immune-related genetic factors, in particular the strongest association ever reported in a disease with an allele of a human leukocyte antigen (HLA) gene, and with environmental factors (i.e., the H1N1 influenza infection and vaccination during the pandemic in 2009) are in favor of such a hypothesis...
October 2017: CNS Drugs
https://www.readbyqxmd.com/read/28751567/the-adamts13-1239-1253-peptide-is-a-dominant-hla-dr1-restricted-cd4-t-cell-epitope
#2
Laurent Gilardin, Sandrine Delignat, Ivan Peyron, Mathieu Ing, Yu-Chun Lone, Bagirath Gangadharan, Baptiste Michard, Yousra Kherabi, Meenu Sharma, Anastas Pashov, Jean-Baptiste Latouche, Mohamad Hamieh, Olivier Toutirais, Pascale Loiseau, Lionel Galicier, Agnès Veyradier, Srini Kaveri, Bernard Maillère, Paul Coppo, Sébastien Lacroix-Desmazes
Acquired thrombotic thrombocytopenic purpura is a rare and severe disease characterized by auto-antibodies directed against "A Disintegrin And Metalloproteinase with Thrombospondin type 1 repeats, 13(th) member" (ADAMTS13), a plasma protein involved in hemostasis. Involvement of CD4(+) T cells in the pathogenesis of the disease is suggested by the IgG isotype of the antibodies. However, the nature of the CD4(+) T-cell epitopes remains poorly characterized. Here, we determined the HLA-DR-restricted CD4(+) T-cell epitopes of ADAMTS13...
November 2017: Haematologica
https://www.readbyqxmd.com/read/28650970/point-of-care-testing-for-toxoplasma-gondii-igg-igm-using-toxoplasma-ict-igg-igm-test-with-sera-from-the-united-states-and-implications-for-developing-countries
#3
Ian J Begeman, Joseph Lykins, Ying Zhou, Bo Shiun Lai, Pauline Levigne, Kamal El Bissati, Kenneth Boyer, Shawn Withers, Fatima Clouser, A Gwendolyn Noble, Peter Rabiah, Charles N Swisher, Peter T Heydemann, Despina G Contopoulos-Ioannidis, Jose G Montoya, Yvonne Maldonado, Raymund Ramirez, Cindy Press, Eileen Stillwaggon, François Peyron, Rima McLeod
BACKGROUND: Congenital toxoplasmosis is a serious but preventable and treatable disease. Gestational screening facilitates early detection and treatment of primary acquisition. Thus, fetal infection can be promptly diagnosed and treated and outcomes can be improved. METHODS: We tested 180 sera with the Toxoplasma ICT IgG-IgM point-of-care (POC) test. Sera were from 116 chronically infected persons (48 serotype II; 14 serotype I-III; 25 serotype I-IIIa; 28 serotype Atypical, haplogroup 12; 1 not typed)...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28615114/experimental-assessment-of-physician-modified-proximal-scalloped-stent-graft-to-extend-proximal-landing-zone-in-the-aortic-arch
#4
E M Faure, I Khantalin, P A Peyron, L Canaud, C Marty-Ané, P Alric
OBJECTIVE/BACKGROUND: The aim of the study was to assess a model of physician modified scalloped stent graft (PMSG) on currently available thoracic aortic devices to extend the proximal landing zone in either zone 2, 1 or 0 of the aortic arch while preserving flow in the supra-aortic vessels on human cadaveric aorta. METHODS: Fresh human aortas were harvested at autopsy from adult subjects. A proximal scallop was made on the stent grafts based on direct measurements on the aortas to extend the proximal landing zone in zone 0 (n = 5), zone 1 (n = 5), and zone 2 (n = 5)...
June 11, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28561798/nf-%C3%AE%C2%BAb-in-hematological-malignancies
#5
REVIEW
Véronique Imbert, Jean-François Peyron
NF-κB (Nuclear Factor Κ-light-chain-enhancer of activated B cells) transcription factors are critical regulators of immunity, stress response, apoptosis, and differentiation. Molecular defects promoting the constitutive activation of canonical and non-canonical NF-κB signaling pathways contribute to many diseases, including cancer, diabetes, chronic inflammation, and autoimmunity. In the present review, we focus our attention on the mechanisms of NF-κB deregulation in hematological malignancies. Key positive regulators of NF-κB signaling can act as oncogenes that are often prone to chromosomal translocation, amplifications, or activating mutations...
May 31, 2017: Biomedicines
https://www.readbyqxmd.com/read/28228437/vertebral-b-cell-lymphoma-mimicking-a-pott-s-disease-in-a-man-aged-63-years-coming-back-from-tunisia
#6
C Pouderoux, C Peyron, C Chidiac, T Ferry
No abstract text is available yet for this article.
February 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28029687/age-related-changes-in-mastication
#7
REVIEW
M A Peyron, A Woda, P Bourdiol, M Hennequin
The paper reviews human mastication, focusing on its age-related changes. The first part describes mastication adaptation in young healthy individuals. Adaptation to obtain a food bolus ready to be swallowed relies on variations in number of cycles, muscle strength and volume of emitted saliva. As a result, the food bolus displays granulometric and rheological properties, the values of which are maintained within the adaptive range of deglutition. The second part concerns healthy ageing. Some mastication parameters are slightly modified by age, but ageing itself does not impair mastication, as the adaptation possibilities remain operant...
December 28, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27450223/assessment-of-the-diagnostic-performance-of-the-ids-isys-tests-for-toxo-igg-toxo-igm-and-avidity
#8
COMPARATIVE STUDY
Pauline Levigne, François Peyron, Martine Wallon
When acquired during pregnancy toxoplasmosis can have devastating consequences on the fetus. As maternal infection is in the majority of cases subclinical, the diagnosis of toxoplasmosis relies on serological tests for the detection of IgG, IGM and the mesure of IgG avidity. We evaluated the performance of IDS-iSYS a new automatized instrument based on chemiluminescence for the diagnosis of the disease. Our study was based on non-selected samples received in our laboratory either for the determination of serological status or for distinguishing acute from chronic infection...
October 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27067006/generation-of-catalytic-antibodies-is-an-intrinsic-property-of-an-individual-s-immune-system-a-study-on-a-large-cohort-of-renal-transplant-patients
#9
Ankit Mahendra, Ivan Peyron, Olivier Thaunat, Cécile Dollinger, Laurent Gilardin, Meenu Sharma, Bharath Wootla, Desirazu N Rao, Séverine Padiolleau-Lefevre, Didier Boquet, Abhijit More, Navin Varadarajan, Srini V Kaveri, Christophe Legendre, Sébastien Lacroix-Desmazes
Renal transplant is the treatment of choice for patients with terminal end-stage renal disease. We have previously identified low levels of catalytic IgG as a potential prognosis marker for chronic allograft rejection. The origin and physiopathological relevance of catalytic Abs is not well understood, owing to the fact that catalytic Abs have been studied in relatively small cohorts of patients with rare diseases and/or without systematic follow-up. In the current study, we have followed the evolution of the levels of catalytic IgG in a large cohort of renal transplant patients over a 2-y period...
May 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/26986117/observational-study-of-a-french-and-belgian-multicenter-cohort-of-23-patients-diagnosed-in-adulthood-with-mevalonate-kinase-deficiency
#10
MULTICENTER STUDY
Cécile-Audrey Durel, Achille Aouba, Boris Bienvenu, Samuel Deshayes, Brigitte Coppéré, Bruno Gombert, Cécile Acquaviva-Bourdain, Eric Hachulla, Frédéric Lecomte, Isabelle Touitou, Jacques Ninet, Jean-Baptiste Philit, Laurent Messer, Marc Brouillard, Marie-Hélène Girard-Madoux, Michel Moutschen, Nadia Raison-Peyron, Pascal Hutin, Pierre Duffau, Pierre Trolliet, Pierre-Yves Hatron, Philippe Heudier, Ramiro Cevallos, Thierry Lequerré, Valentine Brousse, Vincent Lesire, Sylvain Audia, Delphine Maucort-Boulch, Laurence Cuisset, Arnaud Hot
The aim of this study was to describe the clinical and biological features of Mevalonate kinase deficiency (MKD) in patients diagnosed in adulthood. This is a French and Belgian observational retrospective study from 2000 to 2014. To constitute the cohort, we cross-check the genetic and biochemical databases. The clinical, enzymatic, and genetic data were gathered from medical records. Twenty-three patients were analyzed. The mean age at diagnosis was 40 years, with a mean age at onset of symptoms of 3 years...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26785157/functional-brain-imaging-what-has-it-brought-to-our-understanding-of-neuropathic-pain-a-special-focus-on-allodynic-pain-mechanisms
#11
REVIEW
Roland Peyron
Brain responses to nociception are well identified. The same is not true for allodynic pain, a strong painful sensation in response to touch or innocuous cold stimuli that may be experienced by patients with neuropathic pain. Brain (or spinal cord) reorganization that may explain this paradoxical perception still remains largely unknown. Allodynic pain is associated with abnormally increased activity in SII and in the anterior insular cortex, contralateral and/or ipsilateral to allodynia. Because a bilateral increase in activity has been repeatedly reported in these areas in nociceptive conditions, the observed activation during allodynia can explain that a physiologically nonpainful stimulus could be perceived by the damaged nervous system as a painful one...
February 2016: Pain
https://www.readbyqxmd.com/read/26529015/the-saccharomyces-boulardii-cncm-i-745-strain-shows-protective-effects-against-the-b-anthracis-lt-toxin
#12
Rodolphe Pontier-Bres, Patrick Rampal, Jean-François Peyron, Patrick Munro, Emmanuel Lemichez, Dorota Czerucka
The probiotic yeast Saccharomyces boulardii (S. boulardii) has been prescribed for the prophylaxis and treatment of several infectious diarrheal diseases. Gastrointestinal anthrax causes fatal systemic disease. In the present study, we investigated the protective effects conferred by Saccharomyces boulardii CNCM I-745 strain on polarized T84 columnar epithelial cells intoxicated by the lethal toxin (LT) of Bacillus anthracis. Exposure of polarized T84 cells to LT affected cell monolayer integrity, modified the morphology of tight junctions and induced the formation of actin stress fibers...
November 2015: Toxins
https://www.readbyqxmd.com/read/26085297/chronic-intermittent-hypoxia-induces-chronic-low-grade-neuroinflammation-in-the-dorsal-hippocampus-of-mice
#13
Emilie Sapin, Christelle Peyron, Frédéric Roche, Nadine Gay, Carole Carcenac, Marc Savasta, Patrick Levy, Maurice Dematteis
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) induces cognitive impairment that involves intermittent hypoxia (IH). Because OSA is recognized as a low-grade systemic inflammatory disease and only some patients develop cognitive deficits, we investigated whether IH-related brain consequences shared similar pathophysiology and required additional factors such as systemic inflammation to develop. DESIGN: Nine-week-old male C57BL/6J mice were exposed to 1 day, 6 or 24 w of IH (alternating 21-5% FiO2 every 30 sec, 8 h/day) or normoxia...
October 1, 2015: Sleep
https://www.readbyqxmd.com/read/25764140/improving-heart-healthy-lifestyles-among-participants-in-a-salud-para-su-coraz%C3%A3-n-promotores-model-the-mexican-pilot-study-2009-2012
#14
Héctor Balcázar, Ana Cecilia Fernández-Gaxiola, Ana Bertha Pérez-Lizaur, Rosa Adriana Peyron, Carma Ayala
INTRODUCTION: In Mexico, cardiovascular disease and its risk factors are growing problems and major public health concerns. The objective of this study was to implement cardiovascular health promotion and disease prevention activities of the Salud para su Corazón model in a high-risk, impoverished, urban community in Mexico City. METHODS: We used a pretest-posttest (baseline to 12-week follow-up) design without a control group. Material from Salud para su Corazón was validated and delivered by promotores (community health workers) to community members from 6 geographic areas...
2015: Preventing Chronic Disease
https://www.readbyqxmd.com/read/25291481/contact-sensitization-to-modern-dressings-a-multicentre-study-on-354-patients-with-chronic-leg-ulcers
#15
MULTICENTER STUDY
Aude Valois, Julie Waton, Martine Avenel-Audran, François Truchetet, Evelyne Collet, Nadia Raison-Peyron, Jean Francois Cuny, Benjamin Bethune, Jean Luc Schmutz, Annick Barbaud
BACKGROUND: Modern dressings (MDs) may have a low sensitization rate, but there is a lack of prospective studies in patients with chronic leg ulcers (CLUs) to evaluate this. OBJECTIVES: To determine the rate of sensitization (contact allergy) to MDs and substances present in dressings. PATIENTS AND METHODS: A prospective multicentre study was carried out in patients with CLUs at five French dermatology departments; patch tests were performed with the European baseline series and with an additional 27 individual allergens and 10 MDs...
February 2015: Contact Dermatitis
https://www.readbyqxmd.com/read/25118595/saccharomyces-boulardii-modifies-salmonella-typhimurium-traffic-and-host-immune-responses-along-the-intestinal-tract
#16
Rodolphe Pontier-Bres, Patrick Munro, Laurent Boyer, Rodolphe Anty, Véronique Imbert, Chloé Terciolo, Fréderic André, Patrick Rampal, Emmanuel Lemichez, Jean-François Peyron, Dorota Czerucka
Salmonella enterica serovar Typhimurium (ST) is an enteropathogenic Gram-negative bacterium that causes infection following oral ingestion. ST spreads rapidly along the gastrointestinal tract (GIT) and invades the intestinal epithelium to ultimately reach internal body organs. The probiotic yeast Saccharomyces boulardii BIOCODEX (S.b-B) is prescribed for prophylaxis of diarrheal infectious diseases. We previously showed that S.b-B prevents weight loss in ST-infected mice and significantly decreases bacterial translocation to the spleen and liver...
2014: PloS One
https://www.readbyqxmd.com/read/24969045/surgical-management-of-liver-hydatid-disease-subadventitial-cystectomy-versus-resection-of-the-protruding-dome
#17
COMPARATIVE STUDY
Kayvan Mohkam, Leila Belkhir, Martine Wallon, Benjamin Darnis, François Peyron, Christian Ducerf, Jean-François Gigot, Jean-Yves Mabrut
BACKGROUND: The aim of this study was to compare postoperative outcome and long-term results after management of liver hydatid cysts (LHC) by subadventitial cystectomy (SC) and resection of the protruding dome (RPD) in two tertiary liver surgery centers. METHODS: Medical records of 52 patients who underwent SC in one center, and 27 patients who underwent RPD in another center between 1991 and 2011 were reviewed. Patients underwent long-term follow-up, including serology tests and morphological examinations...
August 2014: World Journal of Surgery
https://www.readbyqxmd.com/read/24489475/pain-related-mood-influences-pain-perception-differently-in-fibromyalgia-and-multiple-sclerosis
#18
Céline Borg, Catherine Padovan, Catherine Thomas-Antérion, Céline Chanial, Anaïs Sanchez, Marion Godot, Roland Peyron, Odile De Parisot, Bernard Laurent
In patients, the perception of pain intensity may be influenced by the subjective representation of their disease. Although both multiple sclerosis (MS) and fibromyalgia (FM) possibly include chronic pain, they seem to elicit different disease representations because of the difference in their respective etiology, the former presenting evidence of underlying lesions as opposed to the latter. Thus, we investigated whether patients with FM differed from patients with MS with respect to their perception of "own" pain as well as others' pain...
2014: Journal of Pain Research
https://www.readbyqxmd.com/read/23587746/solar-urticaria-a-time-extended-retrospective-series-of-61-patients-and-review-of-literature
#19
REVIEW
Aurélie Du-Thanh, Anca Debu, Pauline Lalheve, Bernard Guillot, Olivier Dereure, Jean-Louis Peyron
BACKGROUND: Solar urticaria is a rare, disabling, chronic disease. Few large series are available. OBJECTIVE: To report the epidemiological, clinical, phototesting, treatment and patient outcome data of a large series. METHODS: Data from 61 patients' files were retrospectively retrieved in a tertiary referral centre. RESULTS: 43 women and 18 men were included (mean age at first symptoms: 34 y). 3 patients had a medical history of chronic urticaria and 29% of atopy...
April 1, 2013: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/23482562/a-novel-p-1b-type-mn2-transporting-atpase-is-required-for-secreted-protein-metallation-in-mycobacteria
#20
Teresita Padilla-Benavides, Jarukit E Long, Daniel Raimunda, Christopher M Sassetti, José M Argüello
Transition metals are central for bacterial virulence and host defense. P(1B)-ATPases are responsible for cytoplasmic metal efflux and play roles either in limiting cytosolic metal concentrations or in the maturation of secreted metalloproteins. The P(1B)-ATPase, CtpC, is required for Mycobacterium tuberculosis survival in a mouse model (Sassetti, C. M., and Rubin, E. J. (2003) Genetic requirements for mycobacterial survival during infection. Proc. Natl. Acad. Sci. U.S.A. 100, 12989-12994). CtpC prevents Zn(2+) toxicity, suggesting a role in Zn(2+) export from the cytosol (Botella, H...
April 19, 2013: Journal of Biological Chemistry
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