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https://www.readbyqxmd.com/read/29914627/quercetin-treatment-regulates-the-na-k-atpase-activity-peripheral-cholinergic-enzymes-and-oxidative-stress-in-a-rat-model-of-demyelination
#1
Fabiano B Carvalho, Jessié M Gutierres, Diego Beckmann, Rosmarini P Santos, Gustavo R Thomé, Jucimara Baldissarelli, Naiara Stefanello, Amanda Andrades, Graciane Aiello, Angel Ripplinger, Bruna M Lucio, Rafael Ineu, Alexandre Mazzanti, Vera Morsch, Maria Rosa Schetinger, Cinthia M Andrade
Quercetin is reported to exert a plethora of health benefits through many different mechanisms of action. This versatility and presence in the human diet has attracted the attention of the scientific community, resulting in a huge output of in vitro and in vivo (preclinical) studies. Therefore, we hypothesized that quercetin can protect Na+ ,K+ -ATPase activity in the central nervous system, reestablish the peripheral cholinesterases activities, and reduce oxidative stress during demyelination events in rats...
July 2018: Nutrition Research
https://www.readbyqxmd.com/read/29912033/analysis-of-healthcare-institutional-costs-of-pediatric-home-parenteral-nutrition-central-line-infections
#2
Bram P Raphael, Christina Hazenkamp, Mihail Samnaliev, Al Ozonoff
BACKGROUND: While previous literature suggests home parenteral nutrition (HPN) dependent children experience frequent complications like community acquired central line associated bloodstream infections (CLABSI), few studies have characterized the cost. OBJECTIVES: To evaluate institutional cost of community-acquired CLABSI in pediatric HPN patients. METHODS: This is a single center retrospective review of institutional costs for HPN patients with community-acquired CLABSI at a tertiary care children's hospital...
June 13, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29905562/-comparative-morphological-study-of-guided-bone-tissue-regeneration-using-xenogenic-osteoplastic-material-bioplast-dent-and-cerabone
#3
V Chernenko, A Lyubchenko
The purpose of the work is the modeling in the experiment of guided regeneration of bone tissue with the use of osteoplastic materials Bioplast and Cerabone with the subsequent morphological study of their influence on the course of osteoreparation. The experimental-morphological part of the work was performed on 90 mature rats of the Wistar line. The animals were divided into 3 experimental groups. In the first group (30 rats), the osteoplastic material Bioplast-Dent was used; in the second group (30 rats), the osteoplastic material Cerabone was used...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29895301/in-utero-electroporation-induces-cell-death-and-alters-embryonic-microglia-morphology-and-expression-signatures-in-the-developing-hypothalamus
#4
Jessica M Rosin, Deborah M Kurrasch
BACKGROUND: Since its inception in 2001, in utero electroporation (IUE) has been widely used by the neuroscience community. IUE is a technique developed to introduce plasmid DNA into embryonic mouse brains without permanently removing the embryos from the uterus. Given that IUE labels cells that line the ventricles, including radial fibers and migrating neuroblasts, this technique is an excellent tool for studying factors that govern neural cell fate determination and migration in the developing mouse brain...
June 12, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29884572/treatment-and-secondary-prophylaxis-with-ethanol-lock-therapy-for-central-line-associated-bloodstream-infection-in-paediatric-cancer-a-randomised-double-blind-controlled-trial
#5
Joshua Wolf, Tom G Connell, Kim J Allison, Li Tang, Julie Richardson, Kristen Branum, Eloise Borello, Jeffrey E Rubnitz, Aditya H Gaur, Hana Hakim, Yin Su, Sara M Federico, Francoise Mechinaud, Randall T Hayden, Paul Monagle, Leon J Worth, Nigel Curtis, Patricia M Flynn
BACKGROUND: Central line-associated bloodstream infections (CLABSIs) affect about 25% of children with cancer, and treatment failure is common. Adjunctive ethanol lock therapy might prevent treatment failure but high-quality evidence is scarce. We evaluated ethanol lock therapy as treatment and secondary prophylaxis for CLABSI in children with cancer or haematological disorders. METHODS: This randomised, double-blind, placebo-controlled superiority trial, with two interim futility and efficacy analyses (done when the first 46 and 92 evaluable participants completed study requirements), was done at two paediatric hospitals in the USA and Australia...
June 5, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29863780/early-central-line-associated-blood-stream-infections-in-children-with-cancer-pose-a-risk-for-premature-catheter-removal
#6
Jacob Moell, Anna Svenningsson, Margareta Af Sandeberg, Magnus Larsson, Mats Heyman, Arja Harila-Saari, Anna Nilsson
AIM: This study examined the clinical characteristics of central line associated blood stream infections occurring within 30 days after insertion versus later infections in paediatric cancer patients, and the subsequent risk for premature catheter removal. METHODS: This was a retrospective study of children aged 0-18 years who were diagnosed with cancer from 2013-2014 at the Astrid Lindgren Children Hospital, Sweden. Clinical and microbiology data for each patient was collected for 365 days after the central venous catheter was inserted...
June 4, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29863633/central-venous-line-and-dialysis-catheter-position-affects-drug-clearance-during-continuous-renal-replacement-therapy-in-an-animal-model
#7
Robert Frithiof, Anna Bandert, Anders Larsson, Miklos Lipcsey, David Smekal
In intensive care, drugs are commonly administered through central venous catheters (CVC). These catheters and central venous dialysis catheters (CVDC) are often placed in the same vessel for practical reasons. The aim of this experimental study was to investigate if the position of CVC and CVDC influences the elimination of infused drugs, during continuous renal replacement therapy (CRRT). In a randomized, cross-over model, anesthetized piglets received both a CVC and a CVDC in a jugular vein. Another CVDC was placed in a femoral vein for comparison...
May 29, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29849343/delayed-migration-and-perforation-of-the-jugular-vein-by-a-peripherally-inserted-central-catheter
#8
Joshua J Oliver, R Erik Connor, Jacob R Powell, Jessica M Oliver, Brit Long
We report a case of peripherally inserted central catheter (PICC) migration and perforation of the left internal jugular vein in a home health setting in an 80-year-old female. A left sided PICC was placed for treatment of diverticulitis following hospital discharge. She complained of sudden onset left sided neck pain immediately after starting an infusion of vancomycin. In the emergency department the injury was identified by portable chest radiograph and computed tomography of her neck. Following removal of the line, she had an uneventful course...
November 2017: Clinical practice and cases in emergency medicine
https://www.readbyqxmd.com/read/29845627/a-matrix-assisted-laser-desorption-ionization-time-of-flight-time-of-flight-mass-spectrometry-based-toxicoproteomic-screening-method-to-assess-in-vitro-particle-potencies
#9
Marianne B Ariganello, Dharani D Das, Dalibor Breznan, Christine MacKinnon-Roy, Fred Elisma, Aziz Khanchi, Renaud Vincent, Prem Kumarathasan
Knowledge of biological reactivity and underlying toxicity mechanisms of airborne particulate matter (PM) is central to the characterization of the risk associated with these pollutants. An integrated screening platform consisting of protein profiling of cellular responses and cytotoxic analysis was developed in this study for the estimation of PM potencies. Mouse macrophage (J774A.1) and human lung epithelial cells (A549) were exposed in vitro to Ottawa urban particles (EHC6802) and two reference mineral particles (TiO2 and SiO2 )...
May 29, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29794012/stuck-guidewire-due-to-soft-tissue-imposition-a-rare-complication-of-central-line-catheter-placement
#10
Niraj Kumar, Saurav Burman, Anuradha Yadav, Gaurav Singh Tomar
Central venous catheter (CVC) placement is a commonly done procedure but is associated with a few complications, and guidewire-related complications are one of them. In our case after induction of general anaesthesia, we planned to insert a CVC in the right internal jugular vein under ultrasound guidance. After the insertion of the introducer needle, when we tried to insert the guidewire, it got stuck and was neither moving forward nor in a backward direction. Too much force was not applied to remove the guidewire as it might have caused shearing of the guidewire and further complicated the picture...
May 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29778686/methane-correction-factors-for-estimating-emissions-from-aerobic-wastewater-treatment-facilities-based-on-field-data-in-mexico-and-on-literature-review
#11
A Noyola, M G Paredes, L P Güereca, L T Molina, M Zavala
Wastewater treatment (WWT) may be an important source of methane (CH4 ), a greenhouse gas with significant global warming potential. Sources of CH4 emissions from WWT facilities can be found in the water and in the sludge process lines. Among the methodologies for estimating CH4 emissions inventories from WWT, the more adopted are the guidelines of the Intergovernmental Panel on Climate Change (IPCC), which recommends default emission factors (Tier 1) depending on WWT systems. Recent published results show that well managed treatment facilities may emit CH4 , due to dissolved CH4 in the influent wastewater; in addition, biological nutrient removal also will produce this gas in the anaerobic (or anoxic) steps...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29771728/long-term-prognostic-factors-for-visual-improvement-after-epiretinal-membrane-removal
#12
Sohee Jeon, Byungju Jung, Won Ki Lee
PURPOSE: To identify prognostic factors that may predict the amount of long-term visual improvement after idiopathic epiretinal membrane removal. METHODS: A retrospective study of 114 patients who underwent epiretinal membrane removal was performed. The central foveal thickness, inner retinal layer thickness, inner retinal irregularity index, length of the cone outer segment tip line defect, and length of the ellipsoid zone defect were measured. The optical coherence tomography parameters that were associated with the amount of visual improvement were determined at 24 months postoperatively...
May 14, 2018: Retina
https://www.readbyqxmd.com/read/29758372/percutaneous-endoscopic-lumbar-surgery-via-transfacet-approach-for-lumbar-synovial-cyst
#13
Hsuan-Han Wu, Lei Chu, Yong-Jian Zhu, Chun-Yuan Cheng, Chien-Min Chen
BACKGROUND: There are currently no high-quality studies on the optimal therapeutic approach for juxtafacet cyst as treatment guidelines have not been developed. Herein, a novel technique in which using an endoscopic transfacet approach to treat a patient with symptomatic lumbar synovial cyst was presented. . CASE DESCRIPTION: A 87-year-old man presented with severe dull pain in the right anterior thigh had developed. Lumbar magnetic resonance imaging (MRI) revealed disc extrusion over the central canal zone at the L2-3 and L4-L5 level, and an ovoid lesion with a hyperintense center plus a hypointense rim on the T2-weighted image...
May 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29742636/malposition-of-a-central-venous-catheter-in-trauma-confirmation-of-placement-prevents-complications
#14
Steven D Hobbs
This case study presents the inadvertent catheterization of a traumatic hemopneumothorax. A 22-year-old man sustained multiple stab wounds, including the left chest with a resultant hemopneumothorax. Upon arrival at a Level 1 trauma center, an ipsilateral subclavian central catheter was placed, blood was freely aspirated, and because of the patient's critical status, immediately utilized for resuscitation prior to line verification by radiography. A short time later, the catheter was felt to be malpositioned, most likely in the left intrathoracic space, and removed...
May 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/29725181/supratentorial-pure-cortical-ependymoma-an-unusual-lesion-causing-focal-motor-aware-seizure
#15
Manish Beniwal, Ajit Mishra, K V L Narasinga Rao, Vikas Vazhayil, Bevinahalli N Nandeesh, Sampath Somanna
Ependymomas usually arise from the ependymal lining cells of the ventricular system and central canal of the spinal cord. Supratentorial ependymoma is a rare entity with the variable clinical course. In a small number of cases, ependymoma arises from supratentorial parenchyma. Only a few cases are reported in the literature. We report a case of 3-year-old girl with left frontal mass. Total removal of the mass lesion was performed without any neurological deficit. Pathological examination of the excised tumor was consistent with anaplastic ependymoma...
April 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29707506/airway-stents
#16
Erik Folch, Colleen Keyes
Stents and tubes to maintain the patency of the airways are commonly used for malignant obstruction and are occasionally employed in benign disease. Malignant airway obstruction usually results from direct involvement of bronchogenic carcinoma, or by extension of carcinomas occurring in the esophagus or the thyroid. External compression from lymph nodes or metastatic disease from other organs can also cause central airway obstruction. Most malignant airway lesions are surgically inoperable due to advanced disease stage and require multimodality palliation, including stent placement...
March 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29683207/the-wmn1-enhancer-region-in-intron-1-is-required-for-expression-of-human-plp1
#17
Hamdan Hamdan, Pankaj Patyal, Neriman T Kockara, Patricia A Wight
The myelin proteolipid protein gene (PLP1) encodes the most abundant protein present in myelin from the central nervous system (CNS). Its expression must be tightly controlled as evidenced by mutations that alter PLP1 dosage; both overexpression (elevated PLP1 copy number) and lack thereof (PLP1 deletion) result in X-linked genetic disorders in man. However, not much is known about the mechanisms that govern expression of the human gene. To address this, transgenic mice were generated which utilize human PLP1 (hPLP1) sequences (proximal 6...
April 23, 2018: Glia
https://www.readbyqxmd.com/read/29666098/a-misplaced-peripherally-inserted-central-catheter-presenting-as-contralateral-pleural-effusion
#18
Jogender Kumar, Sudeep K C, Kanya Mukhopadhyay, Somosri Ray
A preterm neonate born at 27 weeks, with a birth weight of 555 g, was on continuous positive airway pressure (CPAP) for apnoea of prematurity and initially received total parenteral nutrition (TPN) through the umbilical venous catheter. Peripherally inserted central catheter (PICC) was inserted in the left basilica vein on day 8 to continue TPN. The baby developed respiratory distress with persistent hypoxia after TPN was initiated through the PICC line. The baby required mechanical ventilation due to worsening of respiratory distress, and chest X-ray, as well as ultrasound conducted 12 hours, postinfusion of TPN revealed right-sided pleural effusion...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29627658/routine-chest-x-ray-is-unnecessary-after-ultrasound-guided-central-venous-line-placement-in-the-operating-room
#19
David C Woodland, C Randall Cooper, M Farzan Rashid, Vilma L Rosario, Paul David Weyker, Joshua Weintraub, Stuart Bentley-Hibbert, Michael D Kluger
BACKGROUND: Central venous catheters (CVC) can be useful for perioperative monitoring and insertion has low complication rates. However, routine post insertion chest X-rays have become standard of care and contribute to health care costs with limited impact on patient management. METHODS: 200 patient charts who underwent pancreaticoduodenectomy with central line placement and early line removal were reviewed for clinical complications related to central line placement as well as radiographic evidence of malpositioning...
March 28, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29619323/bacteremia-caused-by-cellulosimicrobium-in-a-bone-marrow-transplant-patient-a-case-report-and-literature-review
#20
Jose Armando Gonzales Zamora, Nicholas Camps
Background: Cellulosimicrobium sp. is a ubiquitous gram-positive bacillus that was formerly known as Oerskovia. This bacterium is found in soil and decaying plant material and is rarely associated with infections in humans. Case report: We report the case of a 44 year-old woman with history of bone marrow transplant that developed Cellulosimicrobium sp. bacteremia secondary to a central line infection. She was admitted with presumed sepsis. Blood cultures from central line and periphery revealed the growth of gram-positive rods that were further identified as Cellulosimicrobium sp ...
2018: IDCases
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