Mariana A Antunes, Cassia L Braga, Tainá B Oliveira, Jamil Z Kitoko, Ligia L Castro, Debora G Xisto, Mariana S Coelho, Nazareth Rocha, Rodrigo P Silva-Aguiar, Celso Caruso-Neves, Eduarda G Martins, Clara Fernandes Carvalho, Antônio Galina, Daniel J Weiss, José R Lapa E Silva, Miquéias Lopes-Pacheco, Fernanda F Cruz, Patricia R M Rocco
Although bone marrow-derived mesenchymal stromal cells (BM-MSCs) from patients with chronic obstructive pulmonary disease (COPD) appear to be phenotypically and functionally similar to BM-MSCs from healthy sources in vitro , the impact of COPD on MSC metabolism and mitochondrial function has not been evaluated. In this study, we aimed to comparatively characterize MSCs from healthy and emphysematous donors (H-MSCs and E-MSCs) in vitro and to assess the therapeutic potential of these MSCs and their extracellular vesicles (H-EVs and E-EVs) in an in vivo model of severe emphysema...
2021: Frontiers in Cell and Developmental Biology