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cytomegalovirus and kidney

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https://www.readbyqxmd.com/read/29669818/changes-in-glomerular-filtration-rate-and-impact-on-long-term-survival-among-adults-after-hematopoietic-cell-transplantation-a-prospective-cohort-study
#1
Sangeeta Hingorani, Emily Pao, Phil Stevenson, Gary Schoch, Benjamin L Laskin, Ted Gooley, George B McDonald
BACKGROUND AND OBJECTIVES: Kidney injury is a significant complication for patients undergoing hematopoietic cell transplantation (HCT), but few studies have prospectively examined changes in GFR in long-term survivors of HCT. We described the association between changes in GFR and all-cause mortality in patients up to 10 years after HCT. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a prospective, observational cohort study of adult patients undergoing HCT at the Fred Hutchinson Cancer Center in Seattle, Washington from 2003 to 2015...
April 18, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29661424/intravenous-immunoglobulin-and-rituximab-in-hla-highly-sensitized-kidney-transplant-recipients
#2
S Querido, A Weigert, T Adragão, J Henriques, R Birne, P Matias, C Jorge, C Nascimento, M Bruges, D Machado
INTRODUCTION: HLA-sensitized patients are penalized both in the access to kidney transplantation (KT) and, once transplanted, in the incidence of rejections and long-term allograft survival despite aggressive induction and maintenance therapy. METHODS: This study retrospectively evaluates the impact of combining T- and B-cell-depleting agents and intravenous immunoglobulin for induction therapy in 45 highly sensitized KT patients (anti-panel reactive antibodies >60%, positive flow cytometry crossmatch or donor specific antibodies at the time of transplantation)...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29661141/diagnostic-utility-of-monitoring-cytomegalovirus-specific-immunity-by-quantiferon-cytomegalovirus-assay-in-kidney-transplant-recipients
#3
Dominika Deborska-Materkowska, Agnieszka Perkowska-Ptasinska, Anna Sadowska, Jolanta Gozdowska, Michał Ciszek, Marta Serwanska-Swietek, Piotr Domagala, Dorota Miszewska-Szyszkowska, Elzbieta Sitarek, Agnieszka Jozwik, Artur Kwiatkowski, Magdalena Durlik
BACKGROUND: Despite universal prophylaxis, late cytomegalovirus (CMV) infection occurs in a high proportion of kidney transplant recipients. We evaluated whether a specific viral T-cell response allows for the better identification of recipients who are at high risk of CMV infection after prophylaxis withdrawal. METHODS: We conducted a prospective study in 19 pretransplant anti-CMV seronegative kidney graft recipients R- (18 from seropositive donors [D+] and one from a seronegative donor [D-]) and 67 seropositive recipients R(+) (59 from seropositive donors and eight from seronegative donors) who received antiviral prophylaxis with valganciclovir...
April 16, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29659606/humoral-immunity-to-memory-antigens-and-pathogens-is-maintained-in-patients-with-chronic-kidney-disease
#4
Nadezhda A Wall, C Coral Dominguez-Medina, Sian E Faustini, Charlotte N Cook, Andrew McClean, Mark D Jesky, Marisol Perez-Toledo, Matthew D Morgan, Alexandra G Richter, Charles J Ferro, Paul Cockwell, Paul A Moss, Ian R Henderson, Lorraine Harper, Adam F Cunningham
Patients with chronic kidney disease (CKD) have an increased risk of infection and poorer responses to vaccination. This suggests that CKD patients have an impaired responsiveness to all antigens, even those first encountered before CKD onset. To examine this we evaluated antibody responses against two childhood vaccine antigens, tetanus (TT) and diphtheria toxoids (DT) and two common pathogens, cytomegalovirus (CMV) and Salmonella enterica serovar Enteritidis (SEn) in two independent cohorts consisting of age-matched individuals with and without CKD...
2018: PloS One
https://www.readbyqxmd.com/read/29624743/absence-of-interaction-between-porcine-endogenous-retrovirus-and-porcine-cytomegalovirus-in-pig-to-baboon-renal-xenotransplantation-in-vivo
#5
Jay A Fishman, David H Sachs, Kazuhiko Yamada, Robert A Wilkinson
BACKGROUND: Studies of xenotransplantation from swine have identified porcine viruses as potential barriers to clinical trials. The biology of these viruses has not been extensively investigated in the in vivo xeno-environment. Enhancement of viral gene expression by viral and cellular factors acting in trans has been demonstrated for certain viruses, including bidirectional interactions between human herpesviruses and endogenous (HERV) and exogenous (HIV) retroviruses. Both porcine cytomegalovirus (PCMV) and porcine endogenous retrovirus (PERV) infections have been identified in xenografts from swine...
April 6, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29622669/secular-trends-in-infection-related-mortality-after-kidney-transplantation
#6
Susanna Kinnunen, Pauli Karhapää, Auni Juutilainen, Patrik Finne, Ilkka Helanterä
BACKGROUND AND OBJECTIVES: Infections are the most common noncardiovascular causes of death after kidney transplantation. We analyzed the current infection-related mortality among kidney transplant recipients in a nationwide cohort in Finland. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Altogether, 3249 adult recipients of a first kidney transplant from 1990 to 2012 were included. Infectious causes of death were analyzed, and the mortality rates for infections were compared between two eras (1990-1999 and 2000-2012)...
April 5, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29611220/cardiovascular-disease-after-transplantation-an-emerging-role-of-the-immune-system
#7
REVIEW
S Van Laecke, T Malfait, E Schepers, W Van Biesen
Cardiovascular disease after transplantation: an emerging role of the immune system. Cardiovascular disease after transplantation remains a major concern. Little is known about what drives the increased cardiovascular risk in transplant recipients apart from traditional risk factors. The immune system is involved in the pathogenesis of hypertension, atherosclerosis, and coronary artery disease in the general population. Recently, inhibition of interleukin 1-β by canakinumab versus placebo decreased the incidence of cardiovascular events...
April 2, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29605690/lack-of-evidence-of-association-between-ifng-and-il28b-polymorphisms-and-quantiferon-cmv-test-results-in-seropositive-transplant-patients
#8
Rocío Aguado, Aurora Páez-Vega, María L Agüera, Miguel Montejo, Lluis Guirado, Jesús Fortún, Alejandro Suárez-Benjumea, Oscar Len, María C Fariñas, Carmen de Gracia, Domingo Hernández, María J Cobos-Ceballos, Julián Torre-Cisneros, Sara Cantisán
The aim of this study was to analyze the relationship between the IFNG+874 T/A and IL28B (rs12979860) C/T polymorphisms and the secretion of IFNG by CD8+ T cells after stimulation with cytomegalovirus (CMV) peptides, measured using QuantiFERON-CMV (QF-CMV) assay. A total of 184 CMV-seropositive solid organ transplant patients (108 kidney, 68 liver and 8 lung) were recruited. Of them, 151 patients were QF-CMV Reactive (IFNG ≥0.2 UI/mL) and 33 were Non-reactive. Genotype frequencies in the study population were TT (26...
March 29, 2018: Human Immunology
https://www.readbyqxmd.com/read/29588161/gene-expression-profiling-scores-in-dual-organ-transplant-patients-are-similar-to-those-in-heart-only-recipients
#9
Sandra A Carey, Kristen M Tecson, Aayla K Jamil, Joost Felius, Theresa K Wolf-Doty, Shelley A Hall
BACKGROUND: Serial gene expression profiling (GEP) may reduce the need for endomyocardial biopsies for detecting acute cellular rejection (ACR) after transplantation, but its performance in dual organ transplant recipients is currently unknown. METHODS: We analyzed 18 months of follow-up in a national cohort of 27 dual organ recipients (18 heart-kidney, 8 heart-liver, 1 heart-lung) matched to 54 heart-only recipients for gender, age, and time to first GEP (AlloMap®) test...
March 24, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29579857/cytomegalovirus-infection-monitoring-based-on-interferon-gamma-release-assay-in-kidney-transplantation
#10
M D C De Gracia-Guindo, M D C Ruiz-Fuentes, P Galindo-Sacristán, J M Osorio-Moratalla, N Ruiz-Fuentes, J Rodriguez Granger, A Osuna-Ortega
BACKGROUND: Cytomegalovirus (CMV) is the most common viral infection after kidney transplantation and is associated with significant morbidity and mortality. Recent studies showed that CMV-specific CD8+ T cells play the crucial role in protection against CMV. The Quantiferon-CMV (QF-CMV) is an interferon gamma (IFN-γ) release assay (IGRA test) that measures the IFN-γ response to a range of T-cell epitopes of CMV. In the present study, we analyzed the clinical utility of QF-CMV assay to predict CMV infection in kidney transplant recipients and evaluated if reactive result in QF-CMV test could be predictor of the duration of treatment...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29579853/survival-and-evolution-of-renal-function-in-kidney-transplant-recipients-from-type-ii-asystolic-donations-a-single-center-experience
#11
N G Toapanta Gaibor, F M González-Roncero, M Cintra Cabrera, M Suñer Poblet, G Bernal Blanco, A Suarez Benjumea, M A Pérez-Valdivia, J J Egea-Guerrero, J L Rocha Castilla, M A Gentil Govantes
BACKGROUND: In recent years, stagnation in the number of kidneys from after brain-dead donors (DBD) has stimulated the use of non-heart beating donors (NHBDs). Herein we present our 5-year experience with type II Maastricht NHBDs in renal transplantation. METHODS: All patients (n = 50) in this study received type II Maastricht NHBD kidneys (March 2012 to February 2017), with a median follow-up of 33 months. RESULTS: Mean donor age was 39 ± 12 years, mean creatinine 1...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29570919/de-novo-cmv-associated-collapsing-focal-segmental-glomerulosclerosis-in-a-kidney-transplant-recipient
#12
Anup M Patel, Robert D Zenenberg, Ryan J Goldberg
Cytomegalovirus (CMV) infection in kidney transplant recipients occurs due to transmission from the donor organ, reactivation of latent infection, or a primary infection. The clinical manifestations of CMV infection range from mild viral syndrome to tissue invasive disease, including colitis, retinitis, meningitis, hepatitis, and pneumonitis. CMV infection can also cause several types of kidney manifestations including tubulointerstitial nephritis and glomerulopathy. Focal segmental glomerulosclerosis (FSGS) after kidney transplantation most often occurs as a result of recurrent disease but de novo FSGS after kidney transplantation has been described (1)...
March 23, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29558877/incidence-and-risk-factors-for-leukopenia-in-kidney-transplant-recipients-receiving-valganciclovir-for-cytomegalovirus-prophylaxis
#13
Xinyun Liang, Olusegun Famure, Yanhong Li, S Joseph Kim
CONTEXT: Valganciclovir is used not only for cytomegalovirus prophylaxis after kidney transplantation but can also induce leukopenia, thereby making patients more susceptible to other infections. The epidemiology of leukopenia in patients on valganciclovir remains poorly understood. OBJECTIVE: To determine the incidence and risk factors for leukopenia in patients receiving valganciclovir for cytomegalovirus prophylaxis after kidney transplantation. METHODS: In this single-center, retrospective, cohort study, we included kidney recipients transplanted from January 1, 2003, to December 31, 2010, to determine the incidence and risk factors for leukopenia in patients who received valganciclovir for cytomegalovirus prophylaxis...
January 1, 2018: Progress in Transplantation
https://www.readbyqxmd.com/read/29546589/valganciclovir-pharmacokinetics-in-patients-receiving-oral-prophylaxis-following-kidney-transplantation-and-model-based-predictions-of-optimal-dosing-regimens
#14
Thomas Tängdén, Pier Giorgio Cojutti, Jason A Roberts, Federico Pea
BACKGROUND AND OBJECTIVES: Valganciclovir is used as oral prophylaxis for cytomegalovirus (CMV) infection in kidney transplant recipients. However, limited pharmacokinetic data exist to guide dosing in this patient group. This study aimed to describe the population pharmacokinetics of valganciclovir in a large sample of kidney transplant recipients and predict optimal dosing based on Monte Carlo simulations. METHODS: Therapeutic drug monitoring (TDM) data from adult kidney transplant recipients who received valganciclovir prophylaxis during a 10-year study period were collected retrospectively...
March 15, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29532473/derivation-of-the-clonal-cell-lines-from-siberian-sturgeon-acipenser-baerii-head-kidney-cell-lines-and-its-applicability-to-foreign-gene-expression-and-virus-culture
#15
J H Ryu, M S Kim, J H Kang, D H Kim, Y K Nam, S P Gong
This study was conducted to establish and characterize the clonal-cell lines from Siberian sturgeon Acipenser baerii head-kidney tissues and to evaluate its applicability as a research tool. From the culture of A. baerii head-kidney derived cells, 10 cell lines were established first and then eight clonal-cell lines were derived from clonal growth and colony expansion of two cell lines that showed significant high colony-forming ability. All eight clonal-cell lines were morphologically similar and grew stably under monolayer culture but their growth rates were significantly different...
March 12, 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29528009/renal-allograft-with-calcium-oxalate-deposition-association-with-urinary-tract-infection-and-development-of-interstitial-fibrosis
#16
B Handan Özdemir, Şebnem Ayva, Gökçe Özdemir, Alev Ok Atılgan, Eda Akçay, F Nurhan Özdemir, Mehmet Haberal
OBJECTIVES: The interaction between calcium oxalate deposition and urinary tract infection is not well established. We aimed to identify the association between these and to determine the role of calcium oxalate deposition on interstitial fibrosis development. MATERIALS AND METHODS: Renal allograft biopsies of 967 patients were reviewed to identify those with calcium oxalate deposition in the renal allograft, with 27 (2.8%) identified. Follow-up biopsies were conducted to reevaluate for calcium oxalate presence and interstitial fibrosis development...
March 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29512688/in-vivo-effects-of-the-nlrp1-nlrp3-inflammasome-pathway-on-latent-respiratory-virus-infection
#17
Yong-Huai Li, Xiang Wei, Shuang Ji, Shu-Yu Gui, Su-Mei Zhang
The present study aimed to investigate the effects of nucleotide-binding domain leucine-rich repeat protein (NLRP)1/NLRP3 inflammasome pathways on latent viral infection of the respiratory tract. A total of 55 BALB/c mice were assigned to the control, bleomycin (BLM)‑treated, murine cytomegalovirus (MCMV), MCMV+BLM and MCMV+BLM+CD4+ T‑cell groups. The viral loads were detected in the salivary glands, kidney, liver and lung tissues via polymerase chain reaction (PCR). The weight, lung coefficient and hydroxyproline (HYP) were detected...
February 28, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29507275/effect-of-angiotensin-ii-receptor-type-1-antibodies-on-kidney-allograft-function
#18
Shokoufeh Savaj, Seyedeh Ghazal Hosseini, Ahad J Ghods
INTRODUCTION: Non-human leukocyte antigen antibodies are an independent risk factor for acute rejection in kidney transplant recipients. Among them, angiotensin II receptor type 1 (ART1) antibodies can induce various effects, but their clinical importance in kidney transplant recipients has not been properly explained. This study aimed to evaluate the effect of ART1 antibodies on allograft function and hypertension in stable kidney transplant recipients. MATERIALS AND METHODS: Eighty-one kidney recipients from non- human leukocyte antigen antibodies-matched donors with stable allograft function were examined for estimated glomerular filtration rate (Chronic Kidney Disease-Epidemiology Collaboration formula) and ART1 antibodies (measured using an enzyme-linked immunosorbent assay method)...
March 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29470680/changes-in-skeletal-muscle-and-body-weight-on-sleeping-beauty-transposon-mediated-transgenic-mice-overexpressing-pig-migf-1
#19
Bo Gao, Wei Wang, Han Wu, Cai Chen, Dan Shen, Saisai Wang, Wei Chen, Li Zhang, Shuheng Chan, Chengyi Song
Insulin-like growth factor (IGF-I) is an important growth factor in mammals, but the functions of the local muscle-specific isoform of insulin-like growth factor 1 (mIGF-1) to skeletal muscle development have rarely been reported. To determine the effect of pig mIGF-1 on body development and muscle deposition in vivo and to investigate the molecular mechanisms, the transgenic mouse model was generated which can also provide experimental data for making transgenic pigs with pig endogenous IGF1 gene. We constructed a skeletal muscle-specific expression vector using 5'- and 3'-regulatory regions of porcine skeletal α-actin gene...
February 22, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29456230/isolated-renal-involvement-of-cytomegalovirus-inclusion-disease-in-an-infant
#20
Subramaniam Murugananth, Rajendran Padmaraj, Natarajan Gopalakrishnan, Rajendran Manorajan, Anila Abraham Kurien, Jeyachandran Dhanapriya, Thanigachalam Dineshkumar, Ramanathan Sakthirajan
Cytomegalovirus (CMV) is the most common cause of congenital infections in humans occurring in 1% of all liveborns. Symptomatic congenital CMV infection involves multiple systems and causes significant morbidity and mortality in newborns. Isolated CMV infection of the kidneys in a living infant has not been reported in literature. Here, we report an infant who presented only with renomegaly and renal biopsy showed extensive CMV inclusions. Serum and urine polymerase chain reaction for CMV were positive, and CMV involvement of other organs was ruled out...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
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