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https://www.readbyqxmd.com/read/29790428/multi-ethnic-sult1a1-copy-number-profiling-with-multiplex-ligation-dependent-probe-amplification
#1
Raymon Vijzelaar, Mariana R Botton, Lisette Stolk, Suparna Martis, Robert J Desnick, Stuart A Scott
AIM: To develop a SULT1A1 multiplex ligation-dependent probe amplification assay and to investigate multi-ethnic copy number variant frequencies. METHODS: A novel multiplex ligation-dependent probe amplification assay was developed and tested on 472 African-American, Asian, Caucasian, Hispanic and Ashkenazi Jewish individuals. RESULTS: The frequencies of atypical total copy number (i.e., greater or less than two) were 38.7% for Hispanics, 38...
May 23, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29788967/towards-a-culturally-competent-health-professional-a-south-african-case-study
#2
Margaret Matthews, Jacqueline Van Wyk
BACKGROUND: South Africa (SA) has a growing multilingual and multicultural population of approximately 55 million people, and faces service delivery challenges due to a shortage in skilled health professionals. Many health care facilities still depict distinct racial and ethnic characteristics that date back to the apartheid era, and there are reports of racial intolerance or preferential treatment at some facilities. There is limited literature in South Africa on cultural competence or on how to train health professionals to provide culturally competent care...
May 22, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29752809/exploring-the-relationship-between-adverse-childhood-experiences-and-oral-health-related-quality-of-life
#3
Faizan Kabani, Kristine Lykens, Hyo Jung Tak
OBJECTIVES: Evidence indicates that adverse childhood experiences (ACEs) have destructive impacts on quality of life, health outcomes, and health-care expenditures. Studies further demonstrate a dose-response relationship between the number of ACEs and risk for experiencing chronic illness, such as oral diseases later in life. Research is scarce on the prioritization of contextualized public health interventions addressing this important threat. METHODS: Cross-sectional data from 2011 to 2012 National Survey of Children's Health (NSCH) provided a nationally representative sample of children in the United States, ages 1-17 for dentate status (n = 61,530)...
May 12, 2018: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/29747660/association-of-the-apoa1-rs964184-snp-and-serum-lipid-traits-in-the-chinese-maonan-and-han-populations
#4
Ling Qiu, Rui-Xing Yin, Eksavang Khounphinith, Fen-Han Zhang, De-Zhai Yang, Shang-Ling Pan
BACKGROUND: Maonan nationality belongs to a mountain ethnic minority in China. Little is known about the association of apolipoprotein A1 gene (APOA1) rs964184 single nucleotide polymorphism (SNP) and serum lipid levels in this population. The aim of this study was to detect the association of the APOA1 rs964184 SNP and several environmental factors with serum lipid profiles in the Chinese Maonan and Han populations. METHODS: Genotypes of the APOA1 rs964184 SNP in 867 individuals of Maonan nationality and 820 participants of Han nationality were determined by polymerase chain reaction and restriction fragment length polymorphism, combined with gel electrophoresis, and confirmed by direct sequencing...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29725898/rates-of-tp53-mutation-are-significantly-elevated-in-african-american-patients-with-gastric-cancer
#5
Elke J A H van Beek, Jonathan M Hernandez, Debra A Goldman, Jeremy L Davis, Kaitlin McLaughlin, R Taylor Ripley, Teresa S Kim, Laura H Tang, Jaclyn F Hechtman, Jian Zheng, Marinela Capanu, Nikolaus Schultz, David M Hyman, Marc Ladanyi, Michael F Berger, David B Solit, Yelena Y Janjigian, Vivian E Strong
BACKGROUND: Gastric adenocarcinoma is a heterogenous disease that results from complex interactions between environmental and genetic factors, which may contribute to the disparate outcomes observed between different patient populations. This study aimed to determine whether genomic differences exist in a diverse population of patients by evaluating tumor mutational profiles stratified by race. METHODS: All patients with gastric adenocarcinoma between 2012 and 2016 who underwent targeted next-generation sequencing of cancer genes by the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets platform were identified...
May 3, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29714606/developing-and-launching-a-research-participant-registry
#6
Jean C McSweeney, Beatrice Boateng, Laura James, Pearl Anna McElfish, David Robinson, Sandra E Hatley, Pamela Christie, Nia Indelicato
BACKGROUND: A major challenge in clinical research today is the difficulty that studies have in meeting recruitment goals. Up to 48% of studies do not meet accrual goals within the specified timeframe, significantly delaying the progress of projects and the dissemination of findings. This pervasive problem is a recruitment crisis. We developed a representative, ethnically and racially diverse research participant registry in a predominantly rural state with high levels of health care disparities and minority populations...
May 1, 2018: Health Communication
https://www.readbyqxmd.com/read/29682207/racial-differences-in-endometrial-cancer-molecular-portraits-in-the-cancer-genome-atlas
#7
David S Guttery, Kevin Blighe, Konstantinos Polymeros, R Paul Symonds, Salvador Macip, Esther L Moss
Endometrial cancer (EC) is now the most prevalent gynaecological malignancy in the Western world. Black or African American women (BoAA) have double the mortality of Caucasian women, and their tumours tend to be of higher grade. Despite these disparities, little is known regarding the mutational landscape of EC between races. Hence, we wished to investigate the molecular features of ECs within The Cancer Genome Atlas (TCGA) dataset by racial groupings. In total 374 Caucasian, 109 BoAA and 20 Asian patients were included in the analysis...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29666002/clinical-pathologic-cytogenetic-and-molecular-profiling-in-self-identified-black-women-with-uterine-leiomyomata
#8
Mark A Hayden, Zehra Ordulu, C Scott Gallagher, Bradley J Quade, Raymond M Anchan, Nia Robinson Middleton, Serene S Srouji, Elizabeth A Stewart, Cynthia C Morton
Black women are disproportionately affected by uterine leiomyomata (UL), or fibroids, compared to other racial groups, having a greater lifetime risk of developing UL and an earlier age of diagnosis. In order to elucidate molecular and genetic mechanisms responsible for the increased prevalence and morbidity associated with UL in black women, clinical, pathologic, cytogenetic, and select molecular profiling (MED12 mutation analysis) of 75 self-reported black women undergoing surgical treatment for UL was performed...
April 2018: Cancer Genetics
https://www.readbyqxmd.com/read/29665027/genetic-variant-spectrum-in-265-chinese-patients-with-hemophagocytic-lymphohistiocytosis-molecular-analyses-of-prf1-unc13d-stx11-stxbp2-sh2d1a-and-xiap
#9
X Chen, F Wang, Y Zhang, W Teng, M Wang, D Nie, X Zhou, D Wang, H Zhao, P Zhu, H Liu
Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening hyperinflammatory disease. This study aimed to investigate the frequencies and distributions of inherited variants in PRF1, UNC13D, STX11, STXBP2, SH2D1A, and XIAP genes in Chinese patients with HLH. A total of 265 patients diagnosed with HLH from January 2010 to December 2016 were recruited and analyzed for the six genes. Genetic variants were observed in 87 (32.83%) patients. 36 (13.58%) exhibited variants in UNC13D, 18 (6.79%) exhibited PRF1 variants, 10 (3...
April 17, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29663154/ambient-air-pollution-and-asthma-related-outcomes-in-children-of-color-of-the-usa-a-scoping-review-of-literature-published-between-2013-and-2017
#10
REVIEW
Anthony Nardone, Andreas M Neophytou, John Balmes, Neeta Thakur
PURPOSE OF REVIEW: Given racial disparities in ambient air pollution (AAP) exposure and asthma risk, this review offers an overview of the literature investigating the ambient air pollution-asthma relationship in children of color between 2013 and 2017. RECENT FINDINGS: AAP is likely a key contributor to the excess burden of asthma in children of color due to pervasive exposure before birth, at home, and in school. Recent findings suggest that psychosocial stressors may modify the relationship between AAP and asthma...
April 16, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29603089/neighborhood-racial-diversity-and-metabolic-syndrome-2003-2008-national-health-and-nutrition-examination-survey
#11
Kelin Li, Ming Wen, Jessie X Fan
This study investigated the independent association between neighborhood racial/ethnic diversity and metabolic syndrome among US adults, and focused on how this association differed across individual and neighborhood characteristics (i.e., race/ethnicity, sex, age, urbanity, neighborhood poverty). Objectively-measured biomarker data from 2003 to 2008 National Health and Nutrition Examination Survey were linked to census-tract profiles from 2000 decennial census (N = 10,122). Multilevel random intercept logistic regression models were estimated to examine the contextual effects of tract-level racial/ethnic diversity on individual risks of metabolic syndrome...
March 30, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29599055/effect-of-participation-in-a-park-based-afterschool-program-on-cardiovascular-disease-risk-among-severely-obese-youth
#12
E M D'Agostino, H H Patel, E Hansen, M S Mathew, M I Nardi, S E Messiah
OBJECTIVES: The prevalence of severe obesity in youth is rising, despite reports of obesity rates stabilizing overall. While reports on treatment outcomes for youth with severe obesity (bariatric surgery, behavioral and pharmacological treatments) exist, very few community-based programs have reported changes in health outcomes in this population. We assessed changes in cardiovascular health risk profiles among racial/ethnic minority youth with severe obesity who participated in Fit2Play™, a park-based afterschool health promotion program...
March 26, 2018: Public Health
https://www.readbyqxmd.com/read/29596498/analyses-of-genome-wide-association-data-cytokines-and-gene-expression-in-african-americans-with-benign-ethnic-neutropenia
#13
Bashira A Charles, Matthew M Hsieh, Adebowale A Adeyemo, Daniel Shriner, Edward Ramos, Kyung Chin, Kshitij Srivastava, Neil A Zakai, Mary Cushman, Leslie A McClure, Virginia Howard, Willy A Flegel, Charles N Rotimi, Griffin P Rodgers
BACKGROUND: Benign ethnic neutropenia (BEN) is a hematologic condition associated with people of African ancestry and specific Middle Eastern ethnic groups. Prior genetic association studies in large population showed that rs2814778 in Duffy Antigen Receptor for Chemokines (DARC) gene, specifically DARC null red cell phenotype, was associated with BEN. However, the mechanism of this red cell phenotype leading to low white cell count remained elusive. METHODS: We conducted an extreme phenotype design genome-wide association study (GWAS), analyzed ~16 million single nucleotide polymorphisms (SNP) in 1,178 African-Americans individuals from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study and replicated from 819 African-American participants in the Atherosclerosis Risk in Communities (ARIC) study...
2018: PloS One
https://www.readbyqxmd.com/read/29589821/the-2017-diabetes-educator-and-the-diabetes-self-management-education-national-practice-survey
#14
Joanne Rinker, Jane K Dickinson, Michelle L Litchman, Ann S Williams, Leslie E Kolb, Carla Cox, Ruth D Lipman
Purpose The American Association of Diabetes Educators conducts the National Practice Survey (NPS) biennially to document current practice in diabetes education in the United States. The purpose of the study is to obtain insight about factors influencing the work of the diabetes educator. Method The 2017 NPS was comprised of 100 questions covering diabetes educator demographics, profile populations of people with diabetes, practice information, program accreditation, program curriculum, staffing, education delivery methods, data collection, and reporting...
March 1, 2018: Diabetes Educator
https://www.readbyqxmd.com/read/29565708/multifaceted-interventions-improve-medication-adherence-and-reduce-acute-hospitalization-rates-in-medicaid-patients-prescribed-asthma-controllers
#15
Andrea D Gelzer, Wanzhen Gao, David Keleti, Thomas Donia, Lauren Megargell, Jeffrey Kreitman, Karen E Michael
OBJECTIVE: To measure the effectiveness of managed care-led interventions in Medicaid subjects with asthma on medication adherence and acute hospitalization in Pennsylvania. METHODS: A total of 3589 members (age range, 5-64 years) served by two Pennsylvania-based Medicaid managed care plans (southeastern Pennsylvania [SEPA] and Lehigh-Capital/New West Pennsylvania [LCNWPA]) with low adherence rates (proportion of days covered [PDC]; 20%-67%) for asthma controller prescription fills in 2012 were guided through a care continuum by a comprehensive asthma strategy, consisting of adherence-improvement interventions (grouped as general intervention [GI] or personalized intervention [PI] for higher-risk subjects)...
March 22, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29536157/association-between-race-and-oncologic-outcome-following-radical-prostatectomy-for-clinically-organ-confined-prostate-cancer-a-long-term-follow-up-study
#16
Erfan Amini, Tracy Campanelli Palmer, Jie Cai, Gary Lieskovsky, Siamak Daneshmand, Hooman Djaladat
PURPOSE: Few studies have evaluated prostate cancer oncologic outcomes in different ethnic groups following radical prostatectomy for clinically organ-confined disease. Existing studies lack long-term outcome data. We conducted this study to assess the impact of racial differences on risk profile and oncologic outcomes in a large cohort of patients with prostate cancer who underwent radical prostatectomy. METHODS: Using our institutional review board-approved prostate cancer database, we retrospectively reviewed the records of 3437 patients who underwent radical prostatectomy with curative intent in our institution between 1987 and 2009...
March 13, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29531773/unique-clinical-characteristics-autoantibodies-and-medication-use-in-native-american-patients-with-systemic-lupus-erythematosus
#17
Joseph M Kheir, Carla J Guthridge, Jonathon R Johnston, Lucas J Adams, Astrid Rasmussen, Timothy F Gross, Melissa E Munroe, Rebecka L Bourn, Kathy L Sivils, Joel M Guthridge, Michael H Weisman, Daniel J Wallace, Juan-Manuel Anaya, Adriana Rojas Villarraga, James N Jarvis, John B Harley, Judith A James
Objective: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with varied morbidity and mortality. We assessed clinical presentations, autoantibody specificities and therapeutic interventions in Native American (NA) patients with SLE. Methods: Patients with SLE meeting 1997 American College of Rheumatology classification criteria (n=3148) were enrolled between 1992 and 2010 in the multiethnic, cross-sectional Lupus Family Registry and Repository...
2018: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29519623/demographic-features-of-patients-with-concomitant-facial-fractures-and-closed-head-injuries-in-maricopa-arizona
#18
Malcolm Harris, Tara Brantley, Douglas Hammond, Sabah Kalamchi
OBJECTIVE: The aim of this study was to investigate the demographic profile of Native American patients with concomitant facial fractures and closed head injuries (CHIs) and to explore the validation of the craniofacial crumple zone. STUDY DESIGN: This was a retrospective, observational, case-control study of 2131 maxillofacial fractures from 2010 to 2014, of which 173 (8%) had concomitant CHIs. RESULTS: Of the study patients, 133 (77%) were males (mean age 40...
January 31, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29498759/lessons-learnt-from-the-epidemiology-of-helicobacter-pylori-infection-in-malaysia-jghf-marshall-and-warren-lecture-2017
#19
REVIEW
Khean-Lee Goh
The study of Helicobacter pylori in Malaysia has given several important insights into the epidemiology of the infection and pathogenesis of disease. Malaysia has a multiracial Asian population with three major Asian races living together-Malay, Chinese, and Indian. Races remain fairly distinct because of a paucity of interracial marriages. The "Racial Cohort Hypothesis" proposes that the infection occurs within racial groups rather than between. As such, the high prevalence among Indians (> 50%) and Chinese (40-50%) reflects the high prevalence in their countries of origin even though migration had taken place more than two generations before...
March 2, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29497447/assessment-of-palatal-rugae-pattern-for-sex-and-ethnicity-identification-in-an-iranian-population
#20
Mahnaz Sheikhi, Mohammad Zandi, Maryam Ghazizadeh
Background: Palatal rugoscopy is a reliable method in the forensic personal identification and racial group specification. the aim of the present study is to use palatal rugae pattern in sex and ethnicity identification applications. Materials and Methods: Four hundred individual dental casts from four different ethnic populations of Iran were randomly selected. The pattern of the palatal rugae (shape, length, and number) investigated and its reliability to classify sex and minor ethnicity for each individual cast was evaluated...
January 2018: Dental Research Journal
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