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https://www.readbyqxmd.com/read/28640116/distribution-of-somatic-mutations-of-cancer-related-genes-according-to-microsatellite-instability-status-in-korean-gastric-cancer
#1
Joonhong Park, Han Mo Yoo, Woori Jang, Soyoung Shin, Myungshin Kim, Yonggoo Kim, Seung-Woo Lee, Jeong Goo Kim
In studies of the molecular basis of gastric cancer (GC), microsatellite instability (MSI) is one of the key factors. Somatic mutations found in GC are expected to contribute to MSI-high (H) tumorigenesis. We estimated somatic mutation distribution according to MSI status in 52 matched pair GC samples using the Ion Torrent Ion S5 XL with the AmpliSeq Cancer Hotspot panel.Seventy-five (9.8%) somatic variants consisting of 34 hotspot mutations and 41 other likely pathogenic variants were identified in 34 GC samples...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28637266/family-caregivers-of-older-adults-1999-2015-trends-in-characteristics-circumstances-and-role-related-appraisal
#2
Jennifer L Wolff, John Mulcahy, Jin Huang, David L Roth, Kenneth Covinsky, Judith D Kasper
Purpose of Study: To assess trends in family caregiving between 1999 and 2015. Design and Methods: We construct nationally representative profiles of community-dwelling older adults receiving help with self-care or indoor mobility and their "primary" family or unpaid caregiver using the 1999 and 2004 National Long Term Care Survey, 2011 and 2015 National Health and Aging Trends Study, and linked caregiver surveys. Trends are examined. Results: Older adults receiving help were incrementally younger, more racially diverse, and better educated in 2015...
June 16, 2017: Gerontologist
https://www.readbyqxmd.com/read/28609485/self-reported-racial-ethnic-discrimination-and-bronchodilator-response-in-african-american-youth-with-asthma
#3
Sonia Carlson, Luisa N Borrell, Celeste Eng, Myngoc Nguyen, Shannon Thyne, Michael A LeNoir, Nadine Burke-Harris, Esteban G Burchard, Neeta Thakur
IMPORTANCE: Asthma is a multifactorial disease composed of endotypes with varying risk profiles and outcomes. African Americans experience a high burden of asthma and of psychosocial stress, including racial discrimination. It is unknown which endotypes of asthma are vulnerable to racial/ethnic discrimination. OBJECTIVE: We examined the association between self-reported racial/ethnic discrimination and bronchodilator response (BDR) among African American youth with asthma ages 8 to 21 years (n = 576) and whether this association varies with tumor necrosis factor alpha (TNF-α) level...
2017: PloS One
https://www.readbyqxmd.com/read/28515047/centrosome-amplification-a-suspect-in-breast-cancer-and-racial-disparities
#4
Angela Ogden, Padmashree C G Rida, Ritu Aneja
The multifaceted involvement of centrosome amplification (CA) in tumorigenesis is coming into focus following years of meticulous experimentation, which have elucidated the powerful abilities of CA to promote cellular invasion, disrupt stem cell division, drive chromosomal instability (CIN), and perturb tissue architecture, activities that can accelerate tumor progression. Integration of the extant in vitro, in vivo, and clinical data suggests that in some tissues CA may be a tumor-initiating event, in others a consequential "hit" in multistep tumorigenesis, and in still others non-tumorigenic...
May 17, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28513790/-sanitation-and-racial-inequality-conditions-in-urban-brazil-an-analysis-focused-on-the-indigenous-population-based-on-the-2010-population-census
#5
Ludimila Raupp, Thatiana Regina Fávaro, Geraldo Marcelo Cunha, Ricardo Ventura Santos
Objective: The aims of this study were to analyze and describe the presence and infrastructure of basic sanitation in the urban areas of Brazil, contrasting indigenous with non-indigenous households. Methods: A cross-sectional study based on microdata from the 2010 Census was conducted. The analyses were based on descriptive statistics (prevalence) and the construction of multiple logistic regression models (adjusted by socioeconomic and demographic covariates). The odds ratios were estimated for the association between the explanatory variables (covariates) and the outcome variables (water supply, sewage, garbage collection, and adequate sanitation)...
January 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/28511680/cohort-profile-seek-test-treat-and-retain-united-states-criminal-justice-cohort
#6
Redonna Chandler, Michael S Gordon, Bridget Kruszka, Lauren N Strand, Frederick L Altice, Curt G Beckwith, Mary L Biggs, William Cunningham, J A Chris Delaney, Patrick M Flynn, Carol E Golin, Kevin Knight, Alex H Kral, Irene Kuo, Jennifer Lorvick, Robin M Nance, Lawrence J Ouellet, Josiah D Rich, Stanley Sacks, David Seal, Anne Spaulding, Sandra A Springer, Faye Taxman, David Wohl, Jeremy D Young, Rebekah Young, Heidi M Crane
BACKGROUND: The STTR treatment cascade provides a framework for research aimed at improving the delivery of services, care and outcomes of PLWH. The development of effective approaches to increase HIV diagnoses and engage PLWH in subsequent steps of the treatment cascade could lead to earlier and sustained ART treatment resulting in viral suppression. There is an unmet need for research applying the treatment cascade to improve outcomes for those with criminal justice involvement. METHODS: The Seek, Test, Treat, and Retain (STTR) criminal justice (CJ) cohort combines data from 11 studies across the HIV treatment cascade that focused on persons involved in the criminal justice system, often but not exclusively for reasons related to substance use...
May 16, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28501022/sociodemographic-profile-of-an-olympic-team
#7
D W Lawrence
OBJECTIVES: To document the distribution of sociodemographic markers (race and relative access to wealth) in athletes participating at the summer and Winter Olympic Games (OGs). STUDY DESIGN: Cross-sectional descriptive epidemiological study. METHODS: Sociodemographic data were collected from publically available resources for all athletes representing four countries (Canada, United States of America, Great Britain and Australia) at the 2014 Sochi Winter OGs and 2016 Rio Summer OGs...
July 2017: Public Health
https://www.readbyqxmd.com/read/28491205/food-insecurity-among-american-indians-and-alaska-natives-a-national-profile-using-the-current-population-survey-food-security-supplement
#8
Valarie Blue Bird Jernigan, Kimberly R Huyser, Jimmy Valdes, Vanessa Watts Simonds
Food insecurity increases the risk for obesity, diabetes, hypertension, and cancer-conditions highly prevalent among American Indians and Alaska Natives (AI/ANs). Using the Current Population Survey Food Security Supplement, we analyzed the food insecurity trends of AI/ANs compared to other racial and ethnic groups in the United States from 2000 to 2010. From 2000 to 2010, 25% of AI/ANs remained consistently food insecure and AI/ANs were twice as likely to be food insecure compared to whites. Urban AI/ANs were more likely to experience food insecurity than rural AI/ANs...
2017: Journal of Hunger & Environmental Nutrition
https://www.readbyqxmd.com/read/28487205/mitochondrial-determinants-of-cancer-health-disparities
#9
REVIEW
Aaheli Roy Choudhury, Keshav K Singh
Mitochondria are involved in the generation of energy, cell growth and differentiation, cellular signaling, cell cycle control, and cell death. To date, the mitochondrial basis of cancer disparities is unknown. The goal of this review is to provide an understanding and a framework of mitochondrial determinants that may contribute to cancer disparities in racially different populations. Mitochondria, which are multi-functional, have been implicated in the initiation and progression of cancers in relation to metabolic alterations in transformed cells...
May 6, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28420504/the-clinical-profile-of-young-and-adolescent-women-with-laparoscopically-diagnosed-endometriosis-in-a-singapore-tertiary-hospital
#10
Yoke-Fai Fong, Soon-Kit Hon, Li-Lian Low, Karen Lim Mei Xian
OBJECTIVE: Endometriosis has been increasingly recognized as the cause of severe dysmenorrhea among younger women including adolescents, often with significant delay from time of presentation to diagnosis. Data on the South East Asian women is scarce. This study aims to describe the disease pattern in a group of young Asian women with histological diagnosis of endometriosis in our center. MATERIALS AND METHODS: A total of 709 laparoscopic operations were performed for endometriosis in our center between 2000 and 2007...
April 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28415965/the-pregnancy-environment-and-lifestyle-study-petals-a-population-based-longitudinal-multi-racial-birth-cohort
#11
Yeyi Zhu, Monique M Hedderson, Juanran Feng, Ashley A Mevi, Assiamira Ferrara
BACKGROUND: Increasing recognition has been received regarding the proven and suggested links between multi-level environmental exposures on a broad scale (e.g., chemical, clinical, behavioral, physical and social) and health deficits originated from the critical window of development. However, such prospective human data are limited. In 2016, the National Institutes of Health funded 35 centers comprising 84 extant cohorts for the Environmental Influences on Child Health Outcomes (ECHO) pediatric cohorts program...
April 17, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28414495/racial-discrimination-racial-identity-and-impostor-phenomenon-a-profile-approach
#12
Donte L Bernard, Lori S Hoggard, Enrique W Neblett
OBJECTIVES: This study examined the association between racial discrimination and the impostor phenomenon (IP) and the moderating influence of racial identity on this relationship. METHOD: One hundred fifty-seven African American college students (68% female; mean age = 18.63) completed measures of racial discrimination, racial identity, and IP during 2 waves of data collection. RESULTS: Utilizing latent profile analyses, 4 patterns of racial identity were identified: Undifferentiated, Multiculturalist, Race-Focused, and Humanist...
April 17, 2017: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/28411317/race-obesity-and-the-renin-angiotensin-aldosterone-system-treatment-response-in-children-with-primary-hypertension
#13
Andrew M South, Lester Arguelles, Gal Finer, Craig B Langman
BACKGROUND: Pediatric primary hypertension (HTN) is increasingly recognized, but the effect of patient characteristics such as obesity and race on treatment outcomes is not well described. The renin-angiotensin-aldosterone system (RAAS) may also contribute to HTN. We hypothesized patient parameters of these factors, including baseline RAAS, influence blood pressure (BP) response to pharmacological treatment in HTN. METHODS: This was a retrospective cohort of 102 consecutive patients with HTN...
April 14, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28410861/prevalence-of-cardiovascular-health-by-occupation-a-cross-sectional-analysis-among-u-s-workers-aged-%C3%A2-45-years
#14
Leslie A MacDonald, Stephen Bertke, Misty J Hein, Suzanne Judd, Sherry Baron, Robert Merritt, Virginia J Howard
INTRODUCTION: Identification of groups with poor cardiovascular health (CVH) can inform where and how to target public health efforts. National prevalence estimates of CVH were derived for clinical (blood glucose, total cholesterol, blood pressure) and behavioral (BMI, diet quality, physical activity, smoking) factors among U.S. workers aged ≥45 years. METHODS: This cross-sectional analysis included 6,282 employed black and white men and women aged ≥45 years enrolled in the national population-based REasons for Geographic And Racial Differences in Stroke study from 2003 to 2007...
April 5, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28403949/racial-differences-in-circulating-levels-of-the-soluble-receptor-for-advanced-glycation-endproducts-in-middle-aged-and-older-adults
#15
Tina E Brinkley, Xiaoyan Leng, Barbara J Nicklas, Stephen B Kritchevsky, Jingzhong Ding, Dalane W Kitzman, W Gregory Hundley
BACKGROUND: Low levels of the soluble receptor for advanced glycation endproducts (sRAGE) have been implicated in a number of chronic diseases. Previous studies indicate that sRAGE levels are ~30% lower in Blacks compared to Whites. However, the reasons for these differences are unclear. PURPOSE: We aimed to identify predictors of circulating sRAGE biomarkers among Black and White adults at high cardiac risk. METHODS: Serum levels of total sRAGE, endogenous secretory RAGE (esRAGE), carboxymethyl-lysine (CML, a major RAGE ligand), and their ratios were measured in 99 Blacks and 454 Whites...
May 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28403016/green-collar-workers-an-emerging-workforce-in-the-environmental-sector
#16
Laura A McClure, William G LeBlanc, Cristina A Fernandez, Lora E Fleming, David J Lee, Kevin J Moore, Alberto J Caban-Martinez
OBJECTIVE: We describe the socio-demographic, occupational, and health characteristics of "green collar" workers, a vital and emerging workforce in energy-efficiency and sustainability. METHODS: We linked data from the 2004 to 2012 National Health Interview Surveys (NHIS) and US Occupational Information Network (O*NET). Descriptive and logistic regression analyses were conducted using green collar worker status as the outcome (n = 143,346). RESULTS: Green collar workers are more likely than non-green workers to be men, age 25 to 64 years, obese, and with less than or equal to high school (HS) education...
May 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28399669/risk-for-spontaneous-preterm-birth-among-inter-racial-ethnic-couples
#17
Bat Zion Shachar, Jonathan A Mayo, Deirdre J Lyell, David K Stevenson, Gary M Shaw, Yair J Blumenfeld
OBJECTIVE: Approximately 10% of US couples are inter-racial/ethnic. Substantial variation in preterm birth (PTB) rates is seen when stratified by race/ethnicity, although most studies focused solely on maternal racial/ethnic demographics. Our aims were to analyze the contribution of paternal in addition to maternal race/ethnicity, and to evaluate risk of spontaneous PTB for previously understudied inter-racial/ethnic couples. METHODS: California singleton live births from 2007 to 2010 were included...
April 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28393320/prevalence-and-ethnic-racial-disparities-in-the-distribution-of-pediatric-injuries-in-south-florida-implications-for-the-development-of-community-prevention-programs
#18
Carmen Ramos Irizarry, Patrick C Hardigan, Mark G Mc Kenney, Gretchen Holmes, Rudy Flores, Brenda Benson, Ascension M Torres
BACKGROUND: The state of Florida continues to report significant gender, ethnic and racial disparities in trauma incidence, access to care and outcomes in the adult population. Our objective was to assess pediatric injury profiles and ethnic/racial disparities of specific injuries in a Regional Trauma Center (TC) in South Florida. METHODS: Retrospective data from November 2011 to December 2015 were obtained from the Level 2 TC registry for children ≤21 years old...
December 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/28376822/internationally-educated-nurses-in-canada-predictors-of-workforce-integration
#19
Christine L Covell, Marie-Douce Primeau, Kelley Kilpatrick, Isabelle St-Pierre
BACKGROUND: Global trends in migration accompanied with recent changes to the immigrant selection process may have influenced the demographic and human capital characteristics of internationally educated nurses (IENs) in Canada and in turn the assistance required to facilitate their workforce integration. This study aimed to describe the demographic and human capital profile of IENs in Canada, to explore recent changes to the profile, and to identify predictors of IENs' workforce integration...
April 4, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28362692/breast-milk-tgf%C3%AE-is-associated-with-neonatal-gut-microbial-composition
#20
Alexandra R Sitarik, Kevin R Bobbitt, Suzanne L Havstad, Kei E Fujimura, Albert M Levin, Edward M Zoratti, Haejin Kim, Kimberley J Woodcroft, Ganesa Wegienka, Dennis R Ownby, Christine L M Joseph, Susan V Lynch, Christine C Johnson
OBJECTIVES: Breast milk is a complex bioactive fluid that varies across numerous maternal and environmental conditions. While breastfeeding is known to impact neonatal gut microbiome, the milk components responsible for this effect are not well-characterized. Given the wide range of immunological activity breast milk cytokines engage in, we investigated three essential breast milk cytokines and their association with early life gut microbiota. METHODS: A total of 52 maternal-child pairs were drawn from a racially diverse birth cohort based in Detroit, Michigan...
March 30, 2017: Journal of Pediatric Gastroenterology and Nutrition
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