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Racial Profiling

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https://www.readbyqxmd.com/read/28327576/genotypic-spectrum-and-phenotype-correlations-of-abca4-associated-disease-in-patients-of-south-asian-descent
#1
Winston Lee, Kaspar Schuerch, Jana Zernant, Frederick T Collison, Srilaxmi Bearelly, Gerald A Fishman, Stephen H Tsang, Janet R Sparrow, Rando Allikmets
Variants in the ABCA4 gene are the most common cause of juvenile-onset blindness affecting close to 1 in 10 000 people worldwide. Disease severity varies largely according to genotype, which can be specific to ethnic and racial groups. Here we investigate the spectrum of ABCA4 variation and its phenotypic expression in 38 patients of South Asian descent, notably from India, Pakistan, Bangladesh and Sri Lanka. Sequencing of all exons and flanking intronic sequences of ABCA4 revealed disease-causing variants in all patients: 3 in 2...
March 22, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28300655/health-conditions-and-racial-differences-among-justice-involved-adolescents-2009-2014
#2
Tyler N A Winkelman, Joseph W Frank, Ingrid A Binswanger, Debra A Pinals
OBJECTIVE: Providers can optimize care for high-risk adolescents by understanding the health risks among the one million US adolescents who interact with the justice system each year. We compared the prevalence of physical health, substance use, and mood disorders among adolescents with and without justice involvement and analyzed differences by race/ethnicity. METHODS: Cross-sectional analysis using the 2009-2014 National Survey on Drug Use and Health (NSDUH). Prevalence data were adjusted for sociodemographic differences between adolescents with and without justice involvement...
March 11, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28275035/racial-and-ethnic-disparities-in-oncotype-dx-test-receipt-in-a-statewide-population-based-study
#3
Brigette A Davis, Jenerius A Aminawung, Maysa M Abu-Khalaf, Suzanne B Evans, Kevin Su, Rajni Mehta, Shi-Yi Wang, Cary P Gross
Background: Racial disparities have been reported in breast cancer care, yet little is known about disparities in access to gene expression profiling (GEP) tests. Given the impact of GEP test results, such as those of Oncotype DX (ODx), on treatment decision-making for hormone receptor-positive (HR+) breast cancer, it is particularly important to assess disparities in its use. Methods: We conducted a retrospective population-based study of 8,784 patients diagnosed with breast cancer in Connecticut during 2011 through 2013...
March 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28239002/racial-dynamics-and-cultural-competence-training-in-medical-and-pharmacy-education
#4
Margarita Echeverri, Theresa Dise
Using the Self-Assessment of Perceived Level of Cultural Competence (SAPLCC) questionnaire, frequencies, means, and ANOVAS were determined to create medical and pharmacy student profiles of cultural competence. Profiles were used to identify needs for training and underscore critical issues that should be given priority in the curriculum. Significant differences were found in several domains of cultural competence (knowledge, skills, attitudes, and abilities); they may be explained by differences in the implementation of a pilot curriculum, the racial composition of students in both programs, and other characteristics...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28198928/biotypology-regionalism-and-the-construction-of-a-plural-brazilian-bodily-identity-1930s
#5
Ana Carolina Vimieiro-Gomes
This article investigates regional biotypological studies and the construction of biological deterministic discourses about the Brazilian identity in the 1930s. Biotypological research was undertaken to determine the normal body type of the Brazilian man, using its peculiar classificatory lexicon. Studies into the bodily profile of specific regions, like the northeast and São Paulo state, featured in this research. In the context of the contemporary debates about race, miscegenation, and national identity, these investigations were geared towards biological determinism and the influence of the environment and social and cultural aspects on the bodily development of Brazilians...
December 2016: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/28181157/comprehensive-neighborhood-portraits-and-child-asthma-disparities
#6
Ashley W Kranjac, Rachel T Kimbro, Justin T Denney, Kristin M Osiecki, Brady S Moffett, Keila N Lopez
Objectives Previous research has established links between child, family, and neighborhood disadvantages and child asthma. We add to this literature by first characterizing neighborhoods in Houston, TX by demographic, economic, and air quality characteristics to establish differences in pediatric asthma diagnoses across neighborhoods. Second, we identify the relative risk of social, economic, and environmental risk factors for child asthma diagnoses. Methods We geocoded and linked electronic pediatric medical records to neighborhood-level social and economic indicators...
February 8, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28165056/risk-profile-and-hiv-testing-outcomes-of-women-undergoing-community-based-testing-in-san-diego-2008-2014
#7
Susannah K Graves, Susan J Little, Martin Hoenigl
Women comprised 19% of new HIV diagnoses in the United States in 2014, with significant racial and ethnic disparities in infection rates. This cross-sectional analysis of women enrolled in a cohort study compares demographics, risk behaviour, and sexually transmitted infections (STI) in those undergoing HIV testing in San Diego County. Data from the most recent screening visit of women undergoing voluntary HIV screening April 2008 -July 2014 was used. HIV diagnosis, risk behaviour and self-reported STIs were compared among women aged ≤24, 25-49, and ≥50, as well as between HIV-infected and uninfected women and between Hispanic and non-Hispanic women...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28159800/a-revised-framingham-stroke-risk-profile-to-reflect-temporal-trends
#8
Carole Dufouil, Alexa S Beiser, Leslie A McClure, Philip A Wolf, Christophe Tzourio, Virginia J Howard, Andrew J Westwood, Jayandra J Himali, Lisa M Sullivan, Hugo J Aparicio, Margaret Kelly-Hayes, Karen Ritchie, Carlos S Kase, Aleksandra Pikula, Jose R Romero, Ralph B D'Agostino, Cécilia Samieri, Ramachandran S Vasan, Genevieve Chêne, George Howard, Sudha Seshadri
BACKGROUND: -Age-adjusted stroke incidence has decreased over the past 50 years, likely due to changes in the prevalence and impact of various stroke risk factors. An updated version of the Framingham Stroke Risk Profile (FSRP) might better predict current risks in the Framingham Heart Study (FHS) and other cohorts. We compared the accuracy of the standard (Old), and of a revised (New) version of the FSRP in predicting the risk of all-stroke and ischemic stroke, and validated this new FSRP in two external cohorts, the 3 Cities (3C) and REGARDS studies...
February 3, 2017: Circulation
https://www.readbyqxmd.com/read/28156528/evaluation-of-patient-s-versus-hematologist-oncologist-s-office-visit-agenda
#9
Kaitlin McIntyre, Rakesh Singal, Damien Mikael Hansra
125 Background: Few studies have been reported in oncology regarding elements of physician agenda. We aim to compare elements of a doctor office visit agenda between hem/onc physicians (MD) and patients (pts). METHODS: Pts and MDs were enrolled to completed a five question survey. Pts were asked: "My doctor" Focuses more on quantity of life and less on quality of life, spends enough time with me, addresses symptoms, addresses chemo side effects, and addresses prognosis. MDs were asked the same questions but worded: "I" spend enough time with pts for example...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28120509/profile-of-hospital-admissions-due-to-self-inflicted-harm-in-los-angeles-county-from-2001-to-2010
#10
Shahrzad Bazargan-Hejazi, Alireza Ahmadi, Mohsen Bazargan, Elham Rahmani, Deyu Pan, Golara Zahmatkesh, Stacey Teruya
We aimed to describe the demographic profile of self-inflicted harm (SIH) in Los Angeles County between 2001 and 2010 and to investigate trends over this 10-year period. We used the California Hospital Discharge Data to investigate all cases of hospital admission due to SIH, including suicide attempts and if they had a concurrent psychiatric diagnosis based on ICD-9 codes. African-Americans (AA) had the highest 10-year SIH admission rates. SIH admission rates remained steady throughout the 10-year study period...
January 25, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28114446/comparison-of-prevalence-and-types-of-mutations-in-lung-cancers-among-black-and-white-populations
#11
Joshua D Campbell, Christopher Lathan, Lynette Sholl, Matthew Ducar, Mikenah Vega, Ashwini Sunkavalli, Ling Lin, Megan Hanna, Laura Schubert, Aaron Thorner, Nicholas Faris, David R Williams, Raymond U Osarogiagbon, Paul van Hummelen, Matthew Meyerson, Laura MacConaill
Importance: Lung cancer is the leading cause of cancer death in the United States in all ethnic and racial groups. The overall death rate from lung cancer is higher in black patients than in white patients. Objective: To compare the prevalence and types of somatic alterations between lung cancers from black patients and white patients. Differences in mutational frequencies could illuminate differences in prognosis and lead to the reduction of outcome disparities by more precisely targeting patients' treatment...
January 19, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28062273/sexual-orientation-and-sleep-in-the-u-s-a-national-profile
#12
Jen-Hao Chen, Cheng-Shi Shiu
INTRODUCTION: Sexual minorities often experience poorer health than non-sexual minorities. However, extant knowledge remains limited regarding the sleep characteristics, a risk factor for chronic diseases and excess mortality, of sexual minorities compared with non-sexual minorities at the population level. METHODS: This study analyzed the 2013-2014 National Health Interview Survey, Adult Sample (n=68,960) to examine the reported sleep duration and sleep disturbances (i...
January 3, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28045435/maternal-circulating-lipid-profile-during-early-pregnancy-racial-ethnic-differences-and-association-with-spontaneous-preterm-delivery
#13
Xinhua Chen, Theresa O Scholl, Thomas P Stein, Robert A Steer, Keith P Williams
Prior reports on the association between altered maternal serum lipid levels with preterm delivery are inconsistent. Ethnic differences in serum lipids during pregnancy and their relation to preterm delivery have not been studied. We examined the relationships of six maternal lipids during early pregnancy with the risk of spontaneous preterm delivery (SPTD). The design represents a case-control study nested within a large prospective, multiethnic cohort of young, generally healthy pregnant women. SPTD cases (n = 183) and controls who delivered at term (n = 376) were included...
January 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28039579/discordance-of-somatic-mutations-between-asian-and-caucasian-patient-populations-with-gastric-cancer
#14
Feifei Jia, Jamie K Teer, Todd C Knepper, Jae K Lee, Hong-Hao Zhou, Yi-Jing He, Howard L McLeod
BACKGROUND: Differences in response to cancer treatments have been observed among racially and ethnically diverse gastric cancer (GC) patient populations. In the era of targeted therapy, mutation profiling of cancer is a crucial aspect of making therapeutic decisions. Mapping driver gene mutations for the GC patient population as a whole has significant potential to advance precision therapy. METHODS: GC patients with sequencing data (N = 473) were obtained from The Cancer Genome Atlas (TCGA; n = 295), Moffitt Cancer Center Total Cancer Care™ (TCC; n = 33), and three published studies (n = 145)...
April 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/27988942/young-healthy-south-asians-have-enhanced-lipogenic-sensitivity-to-dietary-sugar
#15
Lisa C Hudgins, Jonathan L Hugo, Samim Enayat, Thomas S Parker, Amanda S Artis, Daniel M Levine
OBJECTIVE: South Asians have higher rates of type 2 diabetes and cardiovascular disease compared to most other racial/ethnic groups. Increased hepatic de novo lipogenesis (DNL) in response to dietary sugar may accelerate the development of these chronic diseases in this population. STUDY DESIGN: Hepatic DNL in response to a calorically sweetened beverage was measured in an outpatient setting in 15 South Asians and 15 Caucasians with similar and normal body mass indexes, waist circumferences, glucose tolerance and lipid profiles...
March 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/27981233/temporal-and-racial-differences-associated-with-atopic-dermatitis-staphylococcusaureus-and-encoded-virulence-factors
#16
Joseph A Merriman, Elizabeth A Mueller, Michael P Cahill, Lisa A Beck, Amy S Paller, Jon M Hanifin, Peck Y Ong, Lynda Schneider, Denise C Babineau, Gloria David, Alexandre Lockhart, Keli Artis, Donald Y M Leung, Patrick M Schlievert
Atopic dermatitis (AD) is an inflammatory skin condition strongly associated with Staphylococcus aureus colonization and infection. S. aureus strains shift in populations in ~10-year intervals depending on virulence factors. Shifts in S. aureus virulence factors may in part explain the racial differences observed in the levels of prevalence and severity of AD. AD S. aureus isolates collected from 2011 to 2014 (103 isolates) and in 2008 (100 isolates) were examined for the prevalence of genes encoding superantigens (SAgs)...
November 2016: MSphere
https://www.readbyqxmd.com/read/27957339/gender-and-racial-differences-in-the-cardiovascular-risk-factors-among-overweight-and-obese-rural-adults-kuching-and-samarahan-division-sarawak-malaysia
#17
Whye Lian Cheah, Ching Thon Chang, Helmy Hazmi, Wan Manan Wan Muda
Objective. This study aimed to determine whether gender and ethnic differences had an effect on cardiovascular risk factors in overweight and obese rural adults in Sarawak. Design and Setting. This was a cross-sectional study conducted in rural communities in Kuching and Samarahan division, Malaysia. Data was obtained using a set of questionnaire (sociodemographic data and physical activity), measurement of blood pressure, height, weight (body mass index, BMI), body fat percentage, fasting blood sugar, and lipid profile from three ethnic groups-Iban, Malay, and Bidayuh...
2016: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/27926807/evaluation-of-a-national-e-mentoring-program-for-ethnically-diverse-student-nurse-midwives-and-student-midwives
#18
Maria Valentin-Welch
INTRODUCTION: The US racial profile is changing rapidly, yet the nursing and midwifery professions are not evolving accordingly. The lack of racial and ethnic diversity within these health professions negatively affects efforts to eliminate persistent health disparities. To address this issue, the Midwives of Color Committee (MOCC) of the American College of Nurse-Midwives (ACNM) created a national online mentoring program in 2011 to support midwifery students of color. An evaluation of the program is reported here...
November 2016: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/27919353/dyslipidemia-according-to-gender-and-race-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#19
Raul D Santos, Isabela M Bensenor, Alexandre C Pereira, Paulo A Lotufo
BACKGROUND: There is little information regarding lipid profiles of racially mixed populations. Differently from other Latin American countries, the proportion of African ancestry is much higher in Brazil. OBJECTIVE: Verify whether there are differences in the lipid profile between black and white subjects and if people with mixed ancestry have a pattern more closely resembling whites or blacks. METHODS: A total of 15,105 civil servants aged 35-74 years from the ELSA-Brasil study had their fasting lipid profile determined...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27915434/differences-in-the-mutational-landscape-of-triple-negative-breast-cancer-in-african-americans-and-caucasians
#20
Foluso O Ademuyiwa, Yu Tao, Jingqin Luo, Katherine Weilbaecher, Cynthia X Ma
BACKGROUND: Triple-negative breast cancer (TNBC) occurs at higher frequency in African Americans compared with Caucasians. It is unclear if the biology of TNBC is different in African American versus Caucasians. In this study, we sought to evaluate racial differences in the molecular pathology of TNBC. METHODS: Using data from The Cancer Genome Atlas, we identified TNBC patients with information on race. We analyzed differences in clinical characteristics, tumor somatic mutations, and gene expression patterns by race from whole exome and microarray data...
February 2017: Breast Cancer Research and Treatment
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