keyword
https://read.qxmd.com/read/35534232/early-embryonic-mutations-reveal-dynamics-of-somatic-and-germ-cell-lineages-in-mice
#21
JOURNAL ARTICLE
Arikuni Uchimura, Hirotaka Matsumoto, Yasunari Satoh, Yohei Minakuchi, Sayaka Wakayama, Teruhiko Wakayama, Mayumi Higuchi, Masakazu Hashimoto, Ryutaro Fukumura, Atsushi Toyoda, Yoichi Gondo, Takeshi Yagi
De novo mutations accumulate with zygotic cell divisions. However, the occurrence of these mutations and the way they are inherited by somatic cells and germ cells remain unclear. Here, we present a novel method to reconstruct cell lineages. We identified mosaic mutations in mice using deep whole-genome sequencing and reconstructed embryonic cell lineages based on the variant allele frequencies of the mutations. The reconstructed trees were confirmed using nuclear transfer experiments and the genotyping of approximately 50 offspring of each tree...
May 2022: Genome Research
https://read.qxmd.com/read/35488048/effects-of-time-restricted-feeding-and-type-of-food-on-fertility-competence-in-female-mice
#22
JOURNAL ARTICLE
Nafuko Konishi, Hiroshi Matsumoto, Shu Hashimoto, Udayanga Sanath Kankanam Gamage, Daisuke Tachibana, Aisaku Fukuda, Yoshiharu Morimoto, Masayasu Koyama
We assessed the effects of feeding regimen (ad libitum vs. time-restricted food access) and type of food (normal chow (NC: 12% fat) vs. moderately high calorie diet (mHCD: 31% fat)) on fertility competence of female mice. Mice fed mHCD had higher number of oocytes than mice fed NC. On the other hand, when mice were fed NC under time-restricted access to food (NT), the developmental rate to the blastocyst per number of normally fertilized ova was significantly decreased compared to others. The reactive oxygen species (ROS) level in oocytes increased in time-restricted food access and NC group...
April 29, 2022: Scientific Reports
https://read.qxmd.com/read/35142939/physical-behavioral-and-hormonal-changes-in-the-resumption-of-sexual-receptivity-during-postpartum-infertility-in-female-bonobos-at-wamba
#23
JOURNAL ARTICLE
Chie Hashimoto, Heungjin Ryu, Keiko Mouri, Keiko Shimizu, Tetsuya Sakamaki, Takeshi Furuichi
The operational sex ratio (OSR) is used as a predictor for the intensity of mating competition. While many factors affect the OSR, there tends to be a high male bias in primate species with long interbirth intervals and non-seasonal breeding, such as hominid apes. However, the OSR of bonobos (Pan paniscus) is lower than that of chimpanzees (Pan troglodytes), which is thought to reduce competitive and aggressive male behaviors. The low OSR of bonobos is considered to result from the early resumption of female sexual receptivity during postpartum infertility and the receptivity that they continue to show until the late stage of pregnancy...
March 2022: Primates; Journal of Primatology
https://read.qxmd.com/read/34920379/effects-of-an-%C3%AF-3-fatty-acid-biased-diet-on-luteolysis-parturition-and-uterine-prostanoid-synthesis-in-pregnant-mice
#24
JOURNAL ARTICLE
Miho Hashimoto, Nagisa Makino, Tomoaki Inazumi, Rina Yoshida, Toshiko Sugimoto, Soken Tsuchiya, Yukihiko Sugimoto
The ω3 polyunsaturated fatty acids (PUFAs) are known to have beneficial effects on health and diseases, and hence their intake is encouraged. However, it remains unknown as to how ω3 PUFAs affect female reproduction processes, in which ω6 PUFA-derived prostaglandin (PG) E2 and PGF2α play crucial roles. We therefore compared female reproductive performance between ω3 PUFA-biased linseed oil diet-fed (Lin) mice and ω6 PUFA-biased soybean oil diet-fed (Soy) mice. In Lin mice, the uterine levels of arachidonic acid (AA) and eicosapentaenoic acid (EPA) were 0...
December 11, 2021: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/34853329/a-point-mutation-in-the-c-domain-of-cmp-sialic-acid-synthetase-leads-to-lethality-of-medaka-due-to-protein-insolubility
#25
JOURNAL ARTICLE
Di Wu, Hiromu Arakawa, Akiko Fujita, Hisashi Hashimoto, Masahiko Hibi, Kiyoshi Naruse, Yasuhiro Kamei, Chihiro Sato, Ken Kitajima
Vertebrate CMP-sialic acid synthetase (CSS), which catalyzes the synthesis of CMP-sialic acid (CMP-Sia), consists of a 28 kDa-N-domain and a 20 kDa-C-domain. The N-domain is known to be a catalytic domain; however, the significance of the C-domain still remains unknown. To elucidate the function of the C-domain at the organism level, we screened the medaka TILLING library and obtained medaka with non-synonymous mutations (t911a), or single amino acid substitutions of CSS, L304Q, in the C-domain. Prominently, most L304Q medaka was lethal within 19 days post-fertilization (dpf)...
December 1, 2021: Scientific Reports
https://read.qxmd.com/read/34751833/effect-of-x-ray-exposure-during-hysterosalpingography-on-capabilities-of-female-germ-cells
#26
JOURNAL ARTICLE
Hiroshi Matsumoto, Aisaku Fukuda, Satoshi Mizuno, Shu Hashimoto, Yoshiharu Morimoto
PURPOSE: To elucidate the effect of X-ray exposure during hysterosalpingography (HSG) on subsequent laboratory outcomes in in vitro fertilization (IVF). METHODS: A total of 1458 oocytes, consisting of 990 oocytes retrieved from 70 women (89 cycles) who underwent HSG prior to IVF and 468 oocytes from 45 women (57 cycles) who underwent IVF without HSG, were evaluated for their retrieval number, maturity, fertilization, and development post fertilization. X-ray exposure during HSG was recorded as reference air kerma (RAK) (mGy)...
November 9, 2021: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/34609645/comparisons-among-populations-and-individuals-to-evaluate-pollen-pistil-interaction-as-a-mechanism-of-reproductive-interference-in-taraxacum
#27
JOURNAL ARTICLE
Keisuke Hashimoto, Akane Yamamoto, Masahiro M Kanaoka, Akiyo Naiki, Ko-Ichi Takakura, Sachiko Nishida
Reproductive interference (RI), an interspecific mating interaction that reduces the fitness of at least one of the species involved, can lead to exclusive distributions in closely related species. A hypothesis previously proposed is that RI in plants may occur by ovule usurpation, in which pistils lack interspecific incompatibility and mistakenly accept heterospecific pollen, thereby losing an opportunity for conspecific pollen fertilization. However, few comparative studies have evaluated the consistency of the inferred mechanism within and among individuals and populations...
October 5, 2021: Journal of Plant Research
https://read.qxmd.com/read/34513447/thyroxine-replacement-for-subfertile-females-with-subclinical-hypothyroidism-and-autoimmune-thyroiditis-a-systematic-review
#28
REVIEW
Revathi Myneni, Harsh V Chawla, Amit S Grewal, Govinathan Vivekanandan, Andrew Ndakotsu, Ansha P Abubacker, Aimen Iqbal, Safeera Khan
The second most prevalent endocrine condition affecting women of reproductive age is thyroid disease. The difference between an increased thyroid-stimulating hormone (TSH) concentration and a normal free thyroxine hormone level is used to identify subclinical hypothyroidism. Thyroid autoantibodies, independent of thyroid hormone levels, are used to diagnose autoimmune thyroid disease (ATD). Thyroxine can help infertile women with these two types of thyroid illnesses have better birth outcomes during fertility treatment...
August 2021: Curēus
https://read.qxmd.com/read/34418900/interferon-gamma-expression-profile-as-diagnostic-signatures-of-unexplained-infertility-in-female-patients-suffer-from-hashimoto-s-thyroiditis
#29
JOURNAL ARTICLE
Nearmeen M Rashad, Reham Mohamed El Shabrawy, Ahmed M Radwan, Reem M Allam, Rehab S Abdul-Maksoud, Magda M Sherif
Diagnosis of unexplained infertility (UEI) is made by exclusion and a relatively common problem that affects couples worldwide. Unfortunately, it is a not uncommon for females to suffer from Hashimoto's thyroiditis (HT). Interferon-gamma (IFN- γ) has a central key role in HT and in the ability to conceive. We aimed to estimate serum IFN- γ level and its expression profile in Egyptian women with HT and assess their possible association with UEI. In this study, we examined 120 women with HT. We evaluated fertility in all patients; female patients who suffer from UEI were detected...
August 7, 2021: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/34282962/impact-of-maternal-depression-and-anxiety-related-disorders-on-live-birth-rate-in-women-with-recurrent-pregnancy-loss
#30
JOURNAL ARTICLE
Daisuke Shigemi, Yohei Hashimoto, Nobuaki Michihata, Hideo Yasunaga
It is unknown whether depression and anxiety-related conditions associate with poor perinatal outcomes, especially live birth rates, among women diagnosed with recurrent pregnancy loss. We performed a retrospective cohort study using the Japanese Medical Data Centre Claims Database and identified women diagnosed with recurrent pregnancy loss. Live birth rates were compared as the primary outcome between patients with and without depression and/or anxiety-related disorders. A stabilised inverse probability of treatment weight analysis using propensity scores was also performed to assess the association...
July 20, 2021: Human Fertility: Journal of the British Fertility Society
https://read.qxmd.com/read/34129801/intraspecific-variations-of-the-cytoplasmic-male-sterility-genes-orf108-and-orf117-in-brassica-maurorum-and-moricandia-arvensis-and-the-specificity-of-the-mrna-processing
#31
JOURNAL ARTICLE
Hiroshi Yamagishi, Ayako Hashimoto, Asumi Fukunaga, Sang Woo Bang, Toru Terachi
The mitochondrial gene orf108 co-transcribed with atp1 and causes cytoplasmic male sterility in Brassica crops, is widely distributed across wild species and genera of Brassicaceae . However, intraspecific variations in the presence of orf108 have not yet been studied, and the mechanisms for the wide distribution of the gene remain unclear. We analyzed the presence and sequence variations of orf108 in two wild species, Brassica maurorum and Moricandia arvensis . After polymerase chain reaction amplification of the 5' region of atp1 and the coding sequence of orf108 , we determined the DNA sequences...
June 15, 2021: Genome Génome / Conseil National de Recherches Canada
https://read.qxmd.com/read/34093603/effects-of-the-sliaa9-mutation-on-shoot-elongation-growth-of-tomato-cultivars
#32
JOURNAL ARTICLE
Chihiro Abe-Hara, Kohji Yamada, Naoki Wada, Risa Ueta, Ryosuke Hashimoto, Keishi Osakabe, Yuriko Osakabe
Tomato INDOLE-3-ACETIC ACID9 ( SlIAA9 ) is a transcriptional repressor in auxin signal transduction, and SlIAA9 knockout tomato plants develop parthenocarpic fruits without fertilization. We generated sliaa9 mutants with parthenocarpy in several commercial tomato cultivars (Moneymaker, Rio Grande, and Ailsa Craig) using CRISPR-Cas9, and null-segregant lines in the T1 generation were isolated by self-pollination, which was confirmed by PCR and Southern blot analysis. We then estimated shoot growth phenotypes of the mutant plants under different light (low and normal) conditions...
2021: Frontiers in Plant Science
https://read.qxmd.com/read/33984606/proton-beam-therapy-for-children-and-adolescents-and-young-adults-ayas-jastro-and-jspho-guidelines
#33
REVIEW
Masashi Mizumoto, Hiroshi Fuji, Mitsuru Miyachi, Toshinori Soejima, Tetsuya Yamamoto, Norihiro Aibe, Yusuke Demizu, Hiromitsu Iwata, Takayuki Hashimoto, Atsushi Motegi, Atsufumi Kawamura, Keita Terashima, Takashi Fukushima, Tomohei Nakao, Akinori Takada, Minako Sumi, Junjiro Oshima, Kensuke Moriwaki, Miwako Nozaki, Yuji Ishida, Yoshiyuki Kosaka, Keisuke Ae, Ako Hosono, Hideyuki Harada, Etsuyo Ogo, Tetsuo Akimoto, Takashi Saito, Hiroko Fukushima, Ryoko Suzuki, Mitsuru Takahashi, Takayuki Matsuo, Akira Matsumura, Hidekazu Masaki, Hajime Hosoi, Naoyuki Shigematsu, Hideyuki Sakurai
Children and adolescents and young adults (AYAs) with cancer are often treated with a multidisciplinary approach. This includes use of radiotherapy, which is important for local control, but may also cause adverse events in the long term, including second cancer. The risks for limited growth and development, endocrine dysfunction, reduced fertility and second cancer in children and AYAs are reduced by proton beam therapy (PBT), which has a dose distribution that decreases irradiation of normal organs while still targeting the tumor...
April 16, 2021: Cancer Treatment Reviews
https://read.qxmd.com/read/33970370/mural-granulosa-cells-support-to-maintain-the-viability-of-growing-porcine-oocytes-and-its-developmental-competence-after-insemination
#34
JOURNAL ARTICLE
Takayuki Yamochi, Shu Hashimoto, Yoshiharu Morimoto
PURPOSE: To enhance the in vitro growth of porcine oocytes, we studied the effect of mural granulosa cells (MGCs) on the viability of oocytes attached to granulosa cells (oocyte-granulosa cell complexes, OGCs) that were obtained from early antral follicles. METHODS AND RESULTS: When OGCs were cultured with MGCs for 12 days, there were significant improvement (P < 0.05) in the robustness of gap junctional communication between the oocyte and the granulosa cells (82% vs...
May 10, 2021: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/33931821/correction-to-treatment-with-laevo-l-carnitine-reverses-the-mitochondrial-function-of-human-embryos
#35
Naoharu Morimoto, Shu Hashimoto, Masaya Yamanaka, Manabu Satoh, Yoshiharu Nakaoka, Atsushi Fukui, Yoshiharu Morimoto, Hiroaki Shibahara
No abstract text is available yet for this article.
April 30, 2021: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/33907063/community-analysis-based-screening-of-plant-growth-promoting-bacteria-for-sugar-beet
#36
JOURNAL ARTICLE
Kazuyuki Okazaki, Hirohito Tsurumaru, Megumi Hashimoto, Hiroyuki Takahashi, Takashi Okubo, Takuji Ohwada, Kiwamu Minamisawa, Seishi Ikeda
Clone libraries of bacterial 16S rRNA genes (a total of 1,980 clones) were constructed from the leaf blades, petioles, taproots, and lateral roots of sugar beet (Beta vulgaris L.) grown under different fertilization conditions. A principal coordinate analysis revealed that the structures of bacterial communities in above- and underground tissues were largely separated by PC1 (44.5%). The bacterial communities of above-ground tissues (leaf blades and petioles) were more tightly clustered regardless of differences in the tissue types and fertilization conditions than those of below-ground tissues (taproots and lateral roots)...
2021: Microbes and Environments
https://read.qxmd.com/read/33772345/a-single-nucleotide-substitution-in-the-coding-region-of-ogura-male-sterile-gene-orf138-determines-effectiveness-of-a-fertility-restorer-gene-rfo-in-radish
#37
JOURNAL ARTICLE
Hiroshi Yamagishi, Megumi Jikuya, Kanako Okushiro, Ayako Hashimoto, Asumi Fukunaga, Mizuki Takenaka, Toru Terachi
Cytoplasmic male sterility (CMS) observed in many plants leads defect in the production of functional pollen, while the expression of CMS is suppressed by a fertility restorer gene in the nuclear genome. Ogura CMS of radish is induced by a mitochondrial orf138, and a fertility restorer gene, Rfo, encodes a P-type PPR protein, ORF687, acting at the translational level. But, the exact function of ORF687 is still unclear. We found a Japanese variety showing male sterility even in the presence of Rfo. We examined the pollen fertility, Rfo expression, and orf138 mRNA in progenies of this variety...
March 26, 2021: Molecular Genetics and Genomics: MGG
https://read.qxmd.com/read/33750377/hashimoto-s-thyroiditis-worsens-ovaries-in-polycystic-ovary-syndrome-patients-compared-to-anti-m%C3%A3-llerian-hormone-levels
#38
JOURNAL ARTICLE
Aliye Nigar Serin, Özer Birge, Aysel Uysal, Süheyla Görar, Feyza Tekeli
BACKGROUND: The human ovary is the target of autoimmune attack in cases of autoimmune disorders, which can cause ovarian dysfunction. Due to the higher prevalence of Hashimoto's Thyroiditis (HT) in Polycystic Ovary Syndrome (PCOS) patients, we aimed to evaluate ovarian reserve and the effect of autoimmune exposure time on ovarian reserve in PCOS patients with HT by Anti-Müllerian hormone (AMH) levels. METHODS: Forty-six PCOS patients and 46 PCOS with HT diagnosed patients who are between 18 and 35 years old were recruited for this study...
March 9, 2021: BMC Endocrine Disorders
https://read.qxmd.com/read/33646470/a-novel-embryo-quality-scoring-system-to-compare-groups-of-embryos-at-different-developmental-stages
#39
JOURNAL ARTICLE
Satoshi Mizuno, Hiroshi Matsumoto, Shu Hashimoto, Manjula Brahmajosyula, Aya Ohgaki, Sachiyo Tarui, Mari Matoba, Manabu Satoh, Aisaku Fukuda, Yoshiharu Morimoto
PURPOSE: To construct a new embryonic quality scoring system to compare groups of embryos at different developmental stages. METHODS: Based on a hypothesis that the implantation potential of any embryo in an ovum pickup (OPU) cycle remains the same at any stage of development, be it day 2, 3, or 5, a new embryo quality scoring (EQS) system was designed. It was based on the analysis of the clinical results of 1610 single embryo transfers. We validated this scoring system in the comparison of embryonic quality between groups by evaluating the mean scores calculated at day 2, day 3, and day 5 for 957 embryos (150 cycles) from 3 different groups...
March 1, 2021: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/33603561/appearance-of-male-sterile-and-black-radishes-in-the-progeny-of-cross-between-raphanus-raphanistrum-and-raphanus-sativus
#40
JOURNAL ARTICLE
Hiroshi Yamagishi, Ayako Hashimoto, Asumi Fukunaga, Toru Terachi
In addition to Ogura cytoplasmic male sterility (CMS), which is used extensively for F1 hybrid seed production in Brassicaceae crops, two other CMS systems, NWB CMS and DCGMS, have also been identified. The causal gene for the latter two CMS systems has been identified as a novel chimeric gene, orf463 . We previously reported that orf463 is specific to black radish cultivars and that it is present in line 'RS-5' of Raphanus raphanistrum ; however, the orf463 sequence in 'RS-5' differed from that of black radish cultivars...
December 2020: Breeding Science
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