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hashimotos and fertility

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https://www.readbyqxmd.com/read/27903524/graft-versus-host-disease-targets-ovary-and-causes-female-infertility-in-mice
#1
Sonoko Shimoji, Daigo Hashimoto, Hidetsugu Tsujigiwa, Kohta Miyawaki, Koji Kato, Shuichiro Takahashi, Reiki Ogasawara, Takashi Jiromaru, Hiromi Iwasaki, Toshihiro Miyamoto, Koichi Akashi, Takanori Teshima
Infertility associated with ovarian failure is a serious late complication for female survivors of allogeneic hematopoietic stem cell transplantation (SCT). While the role of pretransplant conditioning regimen has been well appreciated, increasing application of reduced-intensity conditioning facilitated us to revisit the other factors possibly affecting ovarian function after allogeneic SCT. We have addressed whether donor T-cell mediated graft-versus-host disease (GVHD) could be causally related to female infertility in mice...
November 30, 2016: Blood
https://www.readbyqxmd.com/read/27652340/somatic-cell-reprogramming-free-generation-of-genetically-modified-pigs
#2
Fuminori Tanihara, Tatsuya Takemoto, Eri Kitagawa, Shengbin Rao, Lanh Thi Kim Do, Akira Onishi, Yukiko Yamashita, Chisato Kosugi, Hitomi Suzuki, Shoichiro Sembon, Shunichi Suzuki, Michiko Nakai, Masakazu Hashimoto, Akihiro Yasue, Munehide Matsuhisa, Sumihare Noji, Tatsuya Fujimura, Dai-Ichiro Fuchimoto, Takeshige Otoi
Genetically modified pigs for biomedical applications have been mainly generated using the somatic cell nuclear transfer technique; however, this approach requires complex micromanipulation techniques and sometimes increases the risks of both prenatal and postnatal death by faulty epigenetic reprogramming of a donor somatic cell nucleus. As a result, the production of genetically modified pigs has not been widely applied. We provide a simple method for CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 gene editing in pigs that involves the introduction of Cas9 protein and single-guide RNA into in vitro fertilized zygotes by electroporation...
September 2016: Science Advances
https://www.readbyqxmd.com/read/27616283/combination-of-density-gradient-centrifugation-and-swim-up-methods-effectively-decreases-morphologically-abnormal-sperms
#3
Masaya Yamanaka, Kazuhisa Tomita, Shu Hashimoto, Hiroshi Matsumoto, Manabu Satoh, Hiromi Kato, Yoshihiko Hosoi, Masayasu Inoue, Yoshiharu Nakaoka, Yoshiharu Morimoto
Density gradient centrifugation (DGC) and swim-up techniques have been reported for semen preparation in assisted reproductive techniques in humans. We investigated whether semen preparation using a combination of DGC and swim-up techniques could effectively decrease morphologically abnormal human sperms at the ultrastructural level. Semen samples were obtained from 16 infertile males and fractionated by swim-up following DGC. Ultrastructural abnormalities of sperms obtained from original semen, lower layer of swim-up following DGC, and upper layer of swim-up following DGC were analyzed by transmission electron microscopy...
September 11, 2016: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/27474397/electroporation-of-cas9-protein-sgrna-into-early-pronuclear-zygotes-generates-non-mosaic-mutants-in-the-mouse
#4
Masakazu Hashimoto, Yukiko Yamashita, Tatsuya Takemoto
The CRISPR/Cas9 system is a powerful tool for elucidating the roles of genes in a wide variety of organisms including mice. To obtain genetically modified embryos or mice by this method, Cas9 mRNA and sgRNA are usually introduced into zygotes by microinjection or electroporation. However, most mutants generated with this method are genetically mosaic, composed of several types of cells carrying different mutations, which complicates phenotype analysis in founder embryos or mice. To simplify the analysis and to elucidate the roles of genes involved in developmental processes, a method for producing non-mosaic mutants is needed...
October 1, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27446569/clinical-investigation-of-the-safety-and-efficacy-of-a-cervical-intraepithelial-neoplasia-treatment-using-a-hyperthermia-device-that-uses-heat-induced-by-alternating-magnetic-fields
#5
Koji Koizumi, Toru Fujioka, Toshiaki Yasuoka, Aya Inoue, Yuka Uchikura, Hiroki Tanaka, Katsuko Takagi, Miki Mori, Masae Koizumi, Hisashi Hashimoto, Takashi Matsumoto, Yuko Matsubara, Keiichi Matsubara, Akihiro Nawa
Multiple techniques have been used for the conservative treatment of high-grade cervical intraepithelial neoplasia (HG-CIN) in women of fertile age. Conization has been associated with stenosis of the cervix and a decrease in cervical mucus secretion, in addition to the increase in the risk of cervical canal shortening and problems during the perinatal period, including premature birth and premature rupture of membranes. Although the laser transpiration technique does not cause shortening of the cervical canal, it is associated with the recurrent risk of deep residual disease...
August 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27117688/dynamic-changes-in-mitochondrial-distribution-in-human-oocytes-during-meiotic-maturation
#6
Yuki Takahashi, Shu Hashimoto, Takayuki Yamochi, Hiroya Goto, Masaya Yamanaka, Ami Amo, Hiroshi Matsumoto, Masayasu Inoue, Keijiro Ito, Yoshiharu Nakaoka, Nao Suzuki, Yoshiharu Morimoto
PURPOSE: The change of mitochondrial distribution in human oocytes during meiotic maturation was assessed using 223 human oocytes donated from patients undergoing fertility treatment between June 2013 and February 2016. METHODS: Live cell images of fluorescence-labelled mitochondria in human oocytes were analysed to investigate dynamic changes in mitochondrial distribution during meiotic maturation using a confocal microscope combined with an incubator in the presence or absence of colchicine and cytochalasin B, inhibitors for tubulin and actin filament, respectively...
July 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27060728/multinucleation-per-se-is-not-always-sufficient-as-a-marker-of-abnormality-to-decide-against-transferring-human-embryos
#7
Shu Hashimoto, Tatsuya Nakano, Kazuo Yamagata, Masayasu Inoue, Yoshiharu Morimoto, Yoshiharu Nakaoka
OBJECTIVE: To assess the developmental competence of human embryos with multinucleation (MN). DESIGN: Experimental study. SETTING: Private fertility center. PATIENT(S): Forty-four couples donating 143 zygotes for confocal imaging study, and 78 couples included in the retrospective clinical study. INTERVENTION(S): Time-lapse imaging study using confocal and light microscopes. MAIN OUTCOME MEASURE(S): Cytokinesis at first mitosis, MN, chromosomal behavior, euploidy, implantation, successful delivery of healthy baby...
July 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/26586820/competition-between-the-brain-and-testes-under-selenium-compromised-conditions-insight-into-sex-differences-in-selenium-metabolism-and-risk-of-neurodevelopmental-disease
#8
Matthew W Pitts, Penny M Kremer, Ann C Hashimoto, Daniel J Torres, China N Byrns, Christopher S Williams, Marla J Berry
UNLABELLED: Selenium (Se) is essential for both brain development and male fertility. Male mice lacking two key genes involved in Se metabolism (Scly(-/-)Sepp1(-/-) mice), selenoprotein P (Sepp1) and Sec lyase (Scly), develop severe neurological dysfunction, neurodegeneration, and audiogenic seizures that manifest beginning in early adulthood. We demonstrate that prepubescent castration of Scly(-/-)Sepp1(-/-) mice prevents behavioral deficits, attenuates neurodegeneration, rescues maturation of GABAergic inhibition, and increases brain selenoprotein levels...
November 18, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26517006/shla-g-and-shla-i-levels-in-follicular-fluid-are-not-associated-with-successful-implantation
#9
Noriko Ouji-Sageshima, Katsuya Yuui, Mari Nakanishi, Nobuyoshi Takeda, Yasushi Odawara, Masanori Yamashita, Hiroshi Iwayama, Keiko Awai, Hirotsugu Hashimoto, Daniel E Geraghty, Akiko Ishitani, Katsuhiko Hatake, Toshihiro Ito
In the field of in vitro fertilization (IVF), useful markers for the prediction of successful implantation for oocyte or embryo selection are essential. It has been reported that sHLA-G (sHLA-G1/HLA-G5) could be detected in the supernatant of the fertilized embryo and in follicular fluid samples (FFs), and that the presence of sHLA-G was related to successful implantation. If sHLA-G could be used as a marker of oocyte selection from multiple FFs, oocytes could be selected without physical contact, thus reducing the likelihood of damage...
February 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/26364763/mitochondrial-dynamics-and-their-intracellular-traffic-in-porcine-oocytes
#10
T Yamochi, S Hashimoto, A Amo, H Goto, M Yamanaka, M Inoue, Y Nakaoka, Y Morimoto
Meiotic maturation of oocytes requires a variety of ATP-dependent reactions, such as germinal vesicle breakdown, spindle formation, and rearrangement of plasma membrane structure, which is required for fertilization. Mitochondria are accordingly expected be localized to subcellular sites of energy utilization. Although microtubule-dependent cellular traffic for mitochondria has been studied extensively in cultured neuronal (and some other somatic) cells, the molecular mechanism of their dynamics in mammalian oocytes at different stages of maturation remains obscure...
August 2016: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/26321722/-is-the-lhrh-agonist-recommended-for-fertility-preservation
#11
Kosei Kimura, Mitsuhiko Iwamoto, Satoru Tanaka, Toru Watanabe, Tomohiko Aihara, Takeki Sugimoto, Kyuichiro Miyara, Mitsuhiro Hayashi, Tsutomu Kouno, Shinichi Baba, Hiroaki Kawashima, Naoki Hashimoto, Kazuhisa Uchiyama
The POEMS reportedan effect of goserelin for fertility preservation. The Clinical Practice Guideline for Breast Cancer by The Japanese Breast Cancer Society indicates that the use of the LHRH agonist (LHRHa) for preventing chemotherapy-induced early menopause is a grade C-1 recommendation, and its use for fertility preservation is a grade C-2 recommendation. Results from previous studies on the effects of LHRHa for fertility preservation have varied owing to differences in chemotherapy regimens, definitions of ovarian failure, and dosages of tamoxifen...
August 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26194606/ontogenic-and-morphological-study-of-gonadal-formation-in-genetically-modified-sex-reversal-xy-pos-mice
#12
Yuria Umemura, Ryosuke Miyamoto, Rie Hashimoto, Kyoko Kinoshita, Takuya Omotehara, Daichi Nagahara, Tetsushi Hirano, Naoto Kubota, Kiichi Minami, Shogo Yanai, Natsumi Masuda, Hideto Yuasa, Youhei Mantani, Eiko Matsuo, Toshifumi Yokoyama, Hiroshi Kitagawa, Nobuhiko Hoshi
Mammalian sexual fate is determined by the presence or absence of sex determining region of the Y chromosome (Sry) in the "bipotential" gonads. Recent studies have demonstrated that both male and female sexual development are induced by distinct and active genetic pathways. Breeding the Y chromosome from Mus m. domesticus poschiavinus (POS) strains into C57BL/6J (B6J) mice (B6J-XY(POS)) has been shown to induce sex reversal (75%: bilateral ovary, 25%: true hermaphrodites). However, our B6N-XY(POS) mice, which were generated by backcrossing of B6J-XY(POS) on an inbred B6N-XX, develop as males (36%: bilateral testis with fertility as well as bilateral ovary (34%), and the remainder develop as true hermaphrodites...
January 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/26088475/selenium-and-iodine-in-autoimmune-thyroiditis
#13
Edoardo Guastamacchia, Vito Angelo Giagulli, Brunella Licchelli, Vincenzo Triggiani
Selenium and iodine are essential for thyroid hormone synthesis and function. Selenium, in form of selenocysteine, is found either in the catalytic center of enzymes involved in the protection of the thyroid gland from free radicals originating during thyroid hormone synthesis, and in three different iodothyronine deiodinases catalyzing the activation and the inactivation of thyroid hormones. Iodine is an essential constituent of thyroid hormones and its deficiency causes different disorders that include goiter, hypothyroidism, reduced fertility and alteration in growth, physical and neurological development...
2015: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/26076042/absent-progesterone-signaling-in-kisspeptin-neurons-disrupts-the-lh-surge-and-impairs-fertility-in-female-mice
#14
Shannon B Z Stephens, Kristen P Tolson, Melvin L Rouse, Matthew C Poling, Minako K Hashimoto-Partyka, Pamela L Mellon, Alexander S Kauffman
Kisspeptin, encoded by Kiss1, stimulates GnRH neurons to govern reproduction. In rodents, estrogen-sensitive kisspeptin neurons in the anterior ventral periventricular nucleus and neighboring periventricular nucleus are thought to mediate sex steroid-induced positive feedback induction of the preovulatory LH surge. These kisspeptin neurons coexpress estrogen and progesterone receptors and display enhanced neuronal activation during the LH surge. However, although estrogen regulation of kisspeptin neurons has been well studied, the role of progesterone signaling in regulating kisspeptin neurons is unknown...
September 2015: Endocrinology
https://www.readbyqxmd.com/read/25943353/nitrate-sensing-and-uptake-in-arabidopsis-are-enhanced-by-abi2-a-phosphatase-inactivated-by-the-stress-hormone-abscisic-acid
#15
Sophie Léran, Kai H Edel, Marjorie Pervent, Kenji Hashimoto, Claire Corratgé-Faillie, Jan Niklas Offenborn, Pascal Tillard, Alain Gojon, Jörg Kudla, Benoît Lacombe
Living organisms sense and respond to changes in nutrient availability to cope with diverse environmental conditions. Nitrate (NO3-) is the main source of nitrogen for plants and is a major component in fertilizer. Unraveling the molecular basis of nitrate sensing and regulation of nitrate uptake should enable the development of strategies to increase the efficiency of nitrogen use and maximize nitrate uptake by plants, which would aid in reducing nitrate pollution. NPF6.3 (also known as NRT1.1), which functions as a nitrate sensor and transporter; the kinase CIPK23; and the calcium sensor CBL9 form a complex that is crucial for nitrate sensing in Arabidopsis thaliana...
May 5, 2015: Science Signaling
https://www.readbyqxmd.com/read/25617086/neonatal-outcomes-after-the-implantation-of-human-embryos-vitrified-using-a-closed-system-device
#16
Hideyuki Iwahata, Shu Hashimoto, Masayasu Inoue, Tomoko Inoue, Keijiro Ito, Yoshiharu Nakaoka, Nao Suzuki, Yoshiharu Morimoto
PURPOSE: Closed vitrification poses a risk of adversely affecting embryo development, while it may minimize the risk of contamination. We assessed the effects of closed-system human embryo vitrification on fetal development after implantation, neonatal outcome, and clinical safety. METHODS: This was a retrospective cohort study conducted at a private fertility clinic. A total of 875 vitrified-warmed blastocysts that were single-transferred under hormone-replacement cycles between November 2011 and December 2013 were randomly divided into two groups (closed vitrification, n 313; open vitrification, n 562) after receiving the patients' consent forms...
April 2015: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/25567618/successful-fertility-preservation-following-ovarian-tissue-vitrification-in-patients-with-primary-ovarian-insufficiency
#17
Nao Suzuki, Nobuhito Yoshioka, Seido Takae, Yodo Sugishita, Midori Tamura, Shu Hashimoto, Yoshiharu Morimoto, Kazuhiro Kawamura
STUDY QUESTION: Is ovarian tissue cryopreservation using vitrification followed by in vitro activation (IVA) of dormant follicles a potential approach for infertility treatment of patients with primary ovarian insufficiency (POI)? SUMMARY ANSWER: Our vitrification approach followed by IVA treatment is a potential infertility therapy for POI patients whose ovaries contain residual follicles. WHAT IS KNOWN ALREADY: Akt (protein kinase B) stimulators [PTEN (phosphatase with TENsin homology deleted in chromosome 10) inhibitor and phosphatidyinositol-3-kinase (PI3 kinase) stimulator] activate dormant primordial follicles in vitro and ovarian fragmentation disrupts the Hippo signaling pathway, leading to the promotion of follicle growth...
March 2015: Human Reproduction
https://www.readbyqxmd.com/read/25548655/a-case-of-chronic-anorexia-nervosa-with-child-bearing-by-in%C3%A2-vitro-fertilization-necessitating-comprehensive-team-support
#18
Shigeru Toki, Eri Hashimoto, Masayuki Masuda, Akihiko Machino, Shigeto Yamawaki
Generalists should be aware of the issues surrounding pregnancy in patients with anorexia nervosa and discuss well with patients and their families before in vitro fertilization.
December 2014: JRSM Open
https://www.readbyqxmd.com/read/25470728/devising-assisted-reproductive-technologies-for-wild-derived-strains-of-mice-37-strains-from-five-subspecies-of-mus-musculus
#19
Keiji Mochida, Ayumi Hasegawa, Naoki Otaka, Daiki Hama, Takashi Furuya, Masaki Yamaguchi, Eri Ichikawa, Maiko Ijuin, Kyuichi Taguma, Michiko Hashimoto, Rika Takashima, Masayo Kadota, Noriko Hiraiwa, Kazuyuki Mekada, Atsushi Yoshiki, Atsuo Ogura
Wild-derived mice have long offered invaluable experimental models for mouse genetics because of their high evolutionary divergence from laboratory mice. A number of wild-derived strains are available from the RIKEN BioResource Center (BRC), but they have been maintained as living stocks because of the unavailability of assisted reproductive technology (ART). In this study, we sought to devise ART for 37 wild-derived strains from five subspecies of Mus musculus maintained at the BRC. Superovulation of females was effective (more than 15 oocytes per female) for 34 out of 37 strains by treatment with either equine chorionic gonadotropin or anti-inhibin serum, depending on their genetic background (subspecies)...
2014: PloS One
https://www.readbyqxmd.com/read/25298178/behavioral-characterization-of-mice-overexpressing-human-dysbindin-1
#20
Norihito Shintani, Yusuke Onaka, Ryota Hashimoto, Hironori Takamura, Tsuyoshi Nagata, Satomi Umeda-Yano, Akihiro Mouri, Takayoshi Mamiya, Ryota Haba, Shinsuke Matsuzaki, Taiichi Katayama, Hidenaga Yamamori, Takanobu Nakazawa, Kazuki Nagayasu, Yukio Ago, Yuki Yagasaki, Toshitaka Nabeshima, Masatoshi Takeda, Hitoshi Hashimoto
BACKGROUND: The dysbindin-1 gene (DTNBP1: dystrobrevin binding protein 1) is a promising schizophrenia susceptibility gene, known to localize almost exclusively to neurons in the brain, and participates in the regulation of neurotransmitter release, membrane-surface receptor expression, and synaptic plasticity. Sandy mice, with spontaneous Dtnbp1 deletion, display behavioral abnormalities relevant to symptoms of schizophrenia. However, it remains unknown if dysbindin-1 gain-of-function is beneficial or detrimental...
2014: Molecular Brain
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