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natural treatment Hashimoto's

Mari Hashimoto, Enrico Girardi, Ruth Eichner, Giulio Superti-Furga
Solute carriers (SLCs) are transmembrane proteins transporting various nutrients, metabolites and drugs across cellular membranes. Despite the relevance of SLCs to cell homeostasis, metabolism and disease states, for the majority of SLCs we lack experimental evidence regarding the nature of the cognate ligands, whether endobiotic or xenobiotic. Moreo-ver, even for the roughly 20 SLCs for which inhibitors have been characterized, engagement assays in cells are limited to accessibility of radiolabeled or fluorescent probes...
May 31, 2018: ACS Chemical Biology
Takahisa Kawaguchi, Toshihide Shima, Masayuki Mizuno, Yasuhide Mitsumoto, Atsushi Umemura, Yoshihiro Kanbara, Saiyu Tanaka, Yoshio Sumida, Kohichiro Yasui, Meiko Takahashi, Keitaro Matsuo, Yoshito Itoh, Katsutoshi Tokushige, Etsuko Hashimoto, Kendo Kiyosawa, Masanori Kawaguchi, Hiroyuki Itoh, Hirofumi Uto, Yasuji Komorizono, Ken Shirabe, Shiro Takami, Toshinari Takamura, Miwa Kawanaka, Ryo Yamada, Fumihiko Matsuda, Takeshi Okanoue
The genetic factors affecting the natural history of nonalcoholic fatty liver disease (NAFLD), including the development of nonalcoholic steatohepatitis (NASH) and NASH-derived hepatocellular carcinoma (NASH-HCC), are still unknown. In the current study, we sought to identify genetic factors related to the development of NAFLD, NASH, and NASH-HCC, and to establish risk-estimation models for them. For these purposes, 936 histologically proven NAFLD patients were recruited, and genome-wide association (GWA) studies were conducted for 902, including 476 NASH and 58 NASH-HCC patients, against 7,672 general-population controls...
2018: PloS One
Łukasz Obołończyk, Małgorzata Siekierska-Hellmann, Piotr Wiśniewski, Anna Lewczuk, Monika Berendt-Obołończyk, Anna Lakomy, Zofia Michalska, Danuta Radowska, Grażyna Moszkowska, Agnieszka Bianek-Bodzak, Krzysztof Sworczak
INTRODUCTION: Hepatitis C virus (HCV) infection is a worldwide problem and hepatitis, which is its natural unfavourable course, is still a challenge for hepatologist. At present, standards of treatment are changing from combined therapy with interferon alpha (IFN-α) and ribavirin to new antiviral drugs. The current classification divides interferon induced thyroid diseases (IITD) into two groups: autoimmune (Hashimoto disease, Graves disease, positive antithyroid autoantibodies in euthyroid patients) and non-autoimmune (destructive thyroiditis, non-autoimmune hypothyroidism)...
September 25, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
Ryuichi Hirayama, Manabu Kinoshita, Hideyuki Arita, Naoki Kagawa, Haruhiko Kishima, Naoya Hashimoto, Yasunori Fujimoto, Toshiki Yoshimine
OBJECTIVE In the present study the authors aimed to determine preferred locations of meningiomas by avoiding descriptive analysis and instead using voxel-based lesion mapping and 3D image-rendering techniques. METHODS Magnetic resonance images obtained in 248 treatment-naïve meningioma patients with 260 lesions were retrospectively and consecutively collected. All images were registered to a 1-mm isotropic, high-resolution, T1-weighted brain atlas provided by the Montreal Neurological Institute (the MNI152), and a lesion frequency map was created, followed by 3D volume rendering to visualize the preferred locations of meningiomas in 3D...
September 1, 2017: Journal of Neurosurgery
Masaaki Oikawa, Shingo Hatakeyama, Tohru Yoneyma, Yuki Tobisawa, Takuma Narita, Hayato Yamamoto, Yasuhiro Hashimoto, Takuya Koie, Shintaro Narita, Atsushi Sasaki, Norihiko Tsuchiya, Tomonori Habuchi, Ippei Takahashi, Shigeyuki Nakaji, Chikara Ohyama
BACKGROUND: The clinical diagnosis of urothelial carcinoma (UC) relies on invasive methods in patients with hematuria. Although more sensitive and noninvasive screening methods are required, a specific serum biomarker for UC is lacking. OBJECTIVE: To examine whether serum glycan-based biomarkers can be applied to UC detection. DESIGN, SETTING, AND PARTICIPANTS: Between April 1994 and June 2016, serum N-glycan concentrations were retrospectively measured in 212 patients with UC before treatment (UC group) and 212 pair-matched controls using glycoblotting and mass spectrometry...
November 22, 2016: European Urology Focus
Michal Arbel-Ornath, Eloise Hudry, Josiah R Boivin, Tadafumi Hashimoto, Shuko Takeda, Kishore V Kuchibhotla, Steven Hou, Carli R Lattarulo, Arianna M Belcher, Naomi Shakerdge, Pariss B Trujillo, Alona Muzikansky, Rebecca A Betensky, Bradley T Hyman, Brian J Bacskai
BACKGROUND: Amyloid-β oligomers (oAβ) are thought to mediate neurotoxicity in Alzheimer's disease (AD), and previous studies in AD transgenic mice suggest that calcium dysregulation may contribute to these pathological effects. Even though AD mouse models remain a valuable resource to investigate amyloid neurotoxicity, the concomitant presence of soluble Aβ species, fibrillar Aβ, and fragments of amyloid precursor protein (APP) complicate the interpretation of the phenotypes. METHOD: To explore the specific contribution of soluble oligomeric Aβ (oAβ) to calcium dyshomeostasis and synaptic morphological changes, we acutely exposed the healthy mouse brain, at 3 to 6 months of age, to naturally occurring soluble oligomers and investigated their effect on calcium levels using in vivo multiphoton imaging...
March 21, 2017: Molecular Neurodegeneration
Ken Fukushi, Takuma Narita, Shingo Hatakeyama, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Chikara Ohyama
OBJECTIVES: To compare toxicity reporting between patients and clinicians in the case of systemic chemotherapy for urothelial carcinoma. METHODS: Between June 2013 and March 2016, 100 urothelial carcinoma patients received two courses of chemotherapy of gemcitabine plus cisplatin or gemcitabine plus carboplatin, and they were prospectively enrolled in the present study. During chemotherapy, patients answered European Organization for the Research and Treatment of Cancer Quality-of-Life Questionnaire C30 quality-of-life questionnaires, including four toxicity-related symptoms (appetite loss, nausea, constipation and diarrhea)...
March 4, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
Keiko Fujino, Yoshiki Hiyama, Teruhisa Uehara, Koji Ichihara, Jiro Hashimoto, Satoshi Fujii, Masaaki Shinagawa, Satoshi Takahashi, Naoya Masumori
The number of patients with acute cystitis caused by extended spectrum β lactamase (ESBL)-producing Escherichia coli (E. coli) is increasing gradually. Although it is reported that ESBL-producing E. coli are sensitive to faropenem (FRPM), there are few clinical studies on the efficiency of FRPM against acute cystitis caused by the bacteria. Therefore, we retrospectively reviewed the medical charts of patients with acute cystitis caused by ESBL-producing E. coli who were treated with the oral antimicrobial agent faropenem (FRPM) in our institution from June 2011 to May 2015...
May 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Jung Eun Lim, Jwa Kyung Sung, Binoy Sarkar, Hailong Wang, Yohey Hashimoto, Daniel C W Tsang, Yong Sik Ok
Metal stabilization using soil amendments is an extensively applied, economically viable and environmentally friendly remediation technique. The stabilization of Pb, Zn and As in contaminated soils was evaluated using natural starfish (NSF) and calcined starfish (CSF) wastes at different application rates (0, 2.5, 5.0 and 10.0 wt%). An incubation study was conducted over 14 months, and the efficiency of stabilization for Pb, Zn and As in soil was evaluated by the toxicity characteristic leaching procedure (TCLP) test...
April 2017: Environmental Geochemistry and Health
D Esposito, M Rotondi, G Accardo, G Vallone, G Conzo, G Docimo, F Selvaggi, C Cappelli, L Chiovato, D Giugliano, D Pasquali
BACKGROUND: The real efficacy of selenium supplementation in Hashimoto's thyroiditis (HT) is still an unresolved issue. OBJECTIVES: We studied the short-term effect of L-selenomethionine on the thyroid function in euthyroid patients with HT. Our primary outcome measures were TSH, thyroid hormones, thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb) levels and thyroid echogenicity after 6 months of L-selenomethionine treatment. The secondary outcome measure was serum CXCL10 levels...
January 2017: Journal of Endocrinological Investigation
Marco Russo, Ilenia Marturano, Romilda Masucci, Melania Caruso, Maria Concetta Fornito, Dario Tumino, Martina Tavarelli, Sebastiano Squatrito, Gabriella Pellegriti
UNLABELLED: Struma ovarii is a rare ovarian teratoma characterized by the presence of thyroid tissue as the major component. Malignant transformation of the thyroidal component (malignant struma ovarii) has been reported in approximately 5% of struma ovarii. The management and follow-up of this unusual disease remain controversial. We report the case of a woman with a history of autoimmune thyroiditis and a previous resection of a benign struma ovarii that underwent hystero-annexiectomy for malignant struma ovarii with multiple papillary thyroid cancer foci and peritoneal involvement...
2016: Endocrinology, Diabetes & Metabolism Case Reports
Junya Makino, Rei Asai, Mao Hashimoto, Tetsuro Kamiya, Hirokazu Hara, Masayuki Ninomiya, Mamoru Koketsu, Tetsuo Adachi
Reactive oxygen species (ROS) produced by endothelial cells and macrophages play important roles in atherogenesis because they promote the formation of oxidized low-density lipoproteins (oxLDL). Extracellular-superoxide dismutase (EC-SOD) is mainly produced by vascular smooth muscle cells (VSMCs), is secreted into the extracellular space, and protects cells from the damaging effects of the superoxide anion. Thus, the expression of EC-SOD in VSMCs is crucial for protecting cells against atherogenesis; however, oxLDL-induced changes in the expression of EC-SOD in VSMCs have not yet been examined...
November 2016: Journal of Cellular Biochemistry
Hiroaki Shiba, Koji Hashimoto, Dympna Kelly, Masato Fujiki, Cristiano Quintini, Federico Aucejo, Teresa Diago Uso, Lisa Yerian, Katsuhiko Yanaga, Masato Matsushima, Bijan Eghtesad, John Fung, Charles Miller
AIM: Hepatitis C virus (HCV) recurrence after liver transplantation decreases survival rates. Improved understanding of the multiple factors influencing HCV recurrence could aid decision-making for donor-recipient pairing and maximize transplant outcomes. The aim of this study was to create a model based on pretransplant variables to stratify patients at risk of HCV-related allograft failure. METHODS: This retrospective study enrolled 154 liver transplant recipients with HCV at Cleveland Clinic...
October 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
L Jiwang, L Zhendong, L Shuchun, H Bo, L Yanguo
It is unclear whether familial non-medullary thyroid carcinoma (FNMTC) is more aggressive than sporadic carcinoma, and its prevalence is still under debate. In this study, we investigated the clinicopathologic features of familial papillary thyroid carcinoma (PTC) compared with its sporadic counterpart. We used data from our hospital between 2008 and 2014 to compare the features of 24 familial PTC with 80 sporadic PTC. The prevalence of familial PTC was 1.5%; 25% of familial PTC exhibited a parent-offspring relationship, and 75% exhibited a sibling relationship...
October 2015: Acta Otorhinolaryngologica Italica
Manuela Battaglia, Laura Nigi, Francesco Dotta
Type 1 diabetes (T1D) is the immune-mediated form of diabetes requiring insulin treatment and affecting both children and adults. The incidence of T1D is increasing dramatically and has doubled in the past 2 decades. In the recent years, significant knowledge on the disease natural history has been gained and, nowadays, diabetes-related autoantibodies make T1D a predictable disease. Despite this great advance in the field of T1D, we still use diagnostic criteria defined by the American Diabetes Association (ADA) in 1997...
December 2015: Current Diabetes Reports
Yu Yokoyama, Kazuichi Maruyama, Hideyuki Konno, Sayaka Hashimoto, Mai Takahashi, Hiroko Kayaba, Taiki Kokubun, Toru Nakazawa
BACKGROUND: The characteristics of glaucoma patients and their response to therapy may differ by institution, region and country. Therefore, clinicians should understand the distinctiveness of their patients. Here, we profile primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients at a major university hospital in Japan. METHODS: This study included 523 eyes from 523 POAG and NTG patients who underwent full clinical ophthalmologic evaluations at Tohoku University Hospital...
2015: BMC Research Notes
Takuya Koie, Chikara Ohyama, Shogo Hosogoe, Hayato Yamamoto, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Tohru Yoneyama, Yuki Tobisawa, Kazuyuki Mori
PURPOSE: A second transurethral resection (TUR) has been recommended by guidelines for high-grade non-muscle-invasive bladder cancer (NMIBC). However, the impact of surgical quality and post-TUR intra-vesical instillation therapy on oncologic outcome still remains unclear for newly diagnosed NMIBC. We conducted a retrospective cohort study for the patients who underwent extensive TUR followed by appropriate intra-vesical therapy for newly diagnosed NMIBC to assess their oncological outcomes...
September 2015: International Urology and Nephrology
Huatao Chen, Keishiro Isayama, Makoto Kumazawa, Lijia Zhao, Nobuhiko Yamauchi, Yasufumi Shigeyoshi, Seiichi Hashimoto, Masa-aki Hattori
The nuclear receptor REV-ERBα links circadian rhythms and numerous physiological processes, but its physiological role in ovaries remains largely unknown. The aim of this study was to determine the potential role of REV-ERBα in the regulation of the transcription of its putative target genes in granulosa cells (GCs) prepared from Per2-destablized luciferase (dLuc) reporter gene transgenic rats. Alas1, Ppargc1a, and Il6 were chosen as representatives for genes analysis. A real-time monitoring system of Per2 promoter activity was performed to detect Per2-dLuc circadian oscillations...
2015: Chronobiology International
Morihiko Sagawa, Takayuki Tabayashi, Yuta Kimura, Tatsuki Tomikawa, Tomoe Nemoto-Anan, Reiko Watanabe, Michihide Tokuhira, Masaki Ri, Yuichi Hashimoto, Shinsuke Iida, Masahiro Kizaki
Although the introduction of bortezomib and immunomodulatory drugs has led to improved outcomes in patients with multiple myeloma, the disease remains incurable. In an effort to identify more potent and well-tolerated agents for myeloma, we have previously reported that 1'-acetoxychavicol acetate (ACA), a natural condiment from South-East Asia, induces apoptotic cell death of myeloma cells in vitro and in vivo through inhibition of NF-κB-related functions. Searching for more potent NF-κB inhibitors, we developed several ACA analogs based on quantitative structure-activity relationship analysis...
April 2015: Cancer Science
Marina Moskalenko, Michael Pan, Yichun Fu, Ellen H de Moll, Daigo Hashimoto, Arthur Mortha, Marylene Leboeuf, Padmini Jayaraman, Sebastian Bernardo, Andrew G Sikora, Jedd Wolchok, Nina Bhardwaj, Miriam Merad, Yvonne Saenger
We sought to define cellular immune mechanisms of synergy between tumor-antigen-targeted monoclonal antibodies and chemotherapy. Established B16 melanoma in mice was treated with cytotoxic doses of cyclophosphamide in combination with an antibody targeting tyrosinase-related protein 1 (αTRP1), a native melanoma differentiation antigen. We find that Fcγ receptors are required for efficacy, showing that antitumor activity of combination therapy is immune mediated. Rag1(-/-) mice deficient in adaptive immunity are able to clear tumors, and thus innate immunity is sufficient for efficacy...
March 2015: Cancer Immunology Research
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