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https://www.readbyqxmd.com/read/27916471/the-efficacy-of-faropenem-for-patients-with-acute-cystitis-caused-by%C3%A2-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli
#1
Keiko Fujino, Yoshiki Hiyama, Teruhisa Uehara, Koji Ichihara, Jiro Hashimoto, Satoshi Fujii, Masaaki Shinagawa, Satoshi Takahashi, Naoya Masumori
The number of patients with acute cystitis caused by extended spectrum β lactamase (ESBL)-producing Escherichia coli (E. coli) is increasing gradually. Although it is reported that ESBL-producing E. coli are sensitive to faropenem (FRPM), there are few clinical studies on the efficiency of FRPM against acute cystitis caused by the bacteria. Therefore, we retrospectively reviewed the medical charts of patients with acute cystitis caused by ESBL-producing E. coli who were treated with the oral antimicrobial agent faropenem (FRPM) in our institution from June 2011 to May 2015...
December 2, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27580613/impact-of-natural-and-calcined-starfish-asterina-pectinifera-on-the-stabilization-of-pb-zn-and-as-in-contaminated-agricultural-soil
#2
Jung Eun Lim, Jwa Kyung Sung, Binoy Sarkar, Hailong Wang, Yohey Hashimoto, Daniel C W Tsang, Yong Sik Ok
Metal stabilization using soil amendments is an extensively applied, economically viable and environmentally friendly remediation technique. The stabilization of Pb, Zn and As in contaminated soils was evaluated using natural starfish (NSF) and calcined starfish (CSF) wastes at different application rates (0, 2.5, 5.0 and 10.0 wt%). An incubation study was conducted over 14 months, and the efficiency of stabilization for Pb, Zn and As in soil was evaluated by the toxicity characteristic leaching procedure (TCLP) test...
August 31, 2016: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/27572248/influence-of-short-term-selenium-supplementation-on-the-natural-course-of-hashimoto-s-thyroiditis-clinical-results-of-a-blinded-placebo-controlled-randomized-prospective-trial
#3
D Esposito, M Rotondi, G Accardo, G Vallone, G Conzo, G Docimo, F Selvaggi, C Cappelli, L Chiovato, D Giugliano, D Pasquali
BACKGROUND: The real efficacy of selenium supplementation in Hashimoto's thyroiditis (HT) is still an unresolved issue. OBJECTIVES: We studied the short-term effect of L-selenomethionine on the thyroid function in euthyroid patients with HT. Our primary outcome measures were TSH, thyroid hormones, thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb) levels and thyroid echogenicity after 6 months of L-selenomethionine treatment. The secondary outcome measure was serum CXCL10 levels...
August 29, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27224256/metastatic-malignant-struma-ovarii-with-coexistence-of-hashimoto-s-thyroiditis
#4
Marco Russo, Ilenia Marturano, Romilda Masucci, Melania Caruso, Maria Concetta Fornito, Dario Tumino, Martina Tavarelli, Sebastiano Squatrito, Gabriella Pellegriti
UNLABELLED: Struma ovarii is a rare ovarian teratoma characterized by the presence of thyroid tissue as the major component. Malignant transformation of the thyroidal component (malignant struma ovarii) has been reported in approximately 5% of struma ovarii. The management and follow-up of this unusual disease remain controversial. We report the case of a woman with a history of autoimmune thyroiditis and a previous resection of a benign struma ovarii that underwent hystero-annexiectomy for malignant struma ovarii with multiple papillary thyroid cancer foci and peritoneal involvement...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/26990420/suppression-of-ec-sod-by-oxldl-during-vascular-smooth-muscle-cell-proliferation
#5
Junya Makino, Rei Asai, Mao Hashimoto, Tetsuro Kamiya, Hirokazu Hara, Masayuki Ninomiya, Mamoru Koketsu, Tetsuo Adachi
Reactive oxygen species (ROS) produced by endothelial cells and macrophages play important roles in atherogenesis because they promote the formation of oxidized low-density lipoproteins (oxLDL). Extracellular-superoxide dismutase (EC-SOD) is mainly produced by vascular smooth muscle cells (VSMCs), is secreted into the extracellular space, and protects cells from the damaging effects of the superoxide anion. Thus, the expression of EC-SOD in VSMCs is crucial for protecting cells against atherogenesis; however, oxLDL-induced changes in the expression of EC-SOD in VSMCs have not yet been examined...
November 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/26833562/risk-stratification-of-allograft-failure-secondary-to-hepatitis-c-recurrence-after-liver-transplantation
#6
Hiroaki Shiba, Koji Hashimoto, Dympna Kelly, Masato Fujiki, Cristiano Quintini, Federico Aucejo, Teresa Diago Uso, Lisa Yerian, Katsuhiko Yanaga, Masato Matsushima, Bijan Eghtesad, John Fung, Charles Miller
Hepatitis C virus (HCV) recurrence after liver transplantation decreases survival rates. Improved understanding of the multiple factors influencing HCV recurrence could aid decision making for donor-recipient pairing and maximize transplant outcomes. The aim of this study was to create a model based on pre-transplant variables to stratify patients at risk of HCV-related allograft failure. This retrospective study enrolled 154 liver transplant recipients with HCV at Cleveland Clinic. Among the study population, 54 recipients (35...
February 1, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/26824209/clinicopathologic-characteristics-of-familial-versus-sporadic-papillary-thyroid-carcinoma
#7
REVIEW
L Jiwang, L Zhendong, L Shuchun, H Bo, L Yanguo
It is unclear whether familial non-medullary thyroid carcinoma (FNMTC) is more aggressive than sporadic carcinoma, and its prevalence is still under debate. In this study, we investigated the clinicopathologic features of familial papillary thyroid carcinoma (PTC) compared with its sporadic counterpart. We used data from our hospital between 2008 and 2014 to compare the features of 24 familial PTC with 80 sporadic PTC. The prevalence of familial PTC was 1.5%; 25% of familial PTC exhibited a parent-offspring relationship, and 75% exhibited a sibling relationship...
October 2015: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/26468153/towards-an-earlier-and-timely-diagnosis-of-type-1-diabetes-is-it-time-to-change-criteria-to-define-disease-onset
#8
REVIEW
Manuela Battaglia, Laura Nigi, Francesco Dotta
Type 1 diabetes (T1D) is the immune-mediated form of diabetes requiring insulin treatment and affecting both children and adults. The incidence of T1D is increasing dramatically and has doubled in the past 2 decades. In the recent years, significant knowledge on the disease natural history has been gained and, nowadays, diabetes-related autoantibodies make T1D a predictable disease. Despite this great advance in the field of T1D, we still use diagnostic criteria defined by the American Diabetes Association (ADA) in 1997...
December 2015: Current Diabetes Reports
https://www.readbyqxmd.com/read/26286038/characteristics-of-patients-with-primary-open-angle-glaucoma-and-normal-tension-glaucoma-at-a-university-hospital-a-cross-sectional-retrospective-study
#9
Yu Yokoyama, Kazuichi Maruyama, Hideyuki Konno, Sayaka Hashimoto, Mai Takahashi, Hiroko Kayaba, Taiki Kokubun, Toru Nakazawa
BACKGROUND: The characteristics of glaucoma patients and their response to therapy may differ by institution, region and country. Therefore, clinicians should understand the distinctiveness of their patients. Here, we profile primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients at a major university hospital in Japan. METHODS: This study included 523 eyes from 523 POAG and NTG patients who underwent full clinical ophthalmologic evaluations at Tohoku University Hospital...
2015: BMC Research Notes
https://www.readbyqxmd.com/read/26149637/oncological-outcomes-of-a-single-but-extensive-transurethral-resection-followed-by-appropriate-intra-vesical-instillation-therapy-for-newly-diagnosed-non-muscle-invasive-bladder-cancer
#10
Takuya Koie, Chikara Ohyama, Shogo Hosogoe, Hayato Yamamoto, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Tohru Yoneyama, Yuki Tobisawa, Kazuyuki Mori
PURPOSE: A second transurethral resection (TUR) has been recommended by guidelines for high-grade non-muscle-invasive bladder cancer (NMIBC). However, the impact of surgical quality and post-TUR intra-vesical instillation therapy on oncologic outcome still remains unclear for newly diagnosed NMIBC. We conducted a retrospective cohort study for the patients who underwent extensive TUR followed by appropriate intra-vesical therapy for newly diagnosed NMIBC to assess their oncological outcomes...
September 2015: International Urology and Nephrology
https://www.readbyqxmd.com/read/26102301/integration-of-the-nuclear-receptor-rev-erb%C3%AE-linked-with-circadian-oscillators-in-the-expressions-of-alas1-ppargc1a-and-il6-genes-in-rat-granulosa-cells
#11
Huatao Chen, Keishiro Isayama, Makoto Kumazawa, Lijia Zhao, Nobuhiko Yamauchi, Yasufumi Shigeyoshi, Seiichi Hashimoto, Masa-aki Hattori
The nuclear receptor REV-ERBα links circadian rhythms and numerous physiological processes, but its physiological role in ovaries remains largely unknown. The aim of this study was to determine the potential role of REV-ERBα in the regulation of the transcription of its putative target genes in granulosa cells (GCs) prepared from Per2-destablized luciferase (dLuc) reporter gene transgenic rats. Alas1, Ppargc1a, and Il6 were chosen as representatives for genes analysis. A real-time monitoring system of Per2 promoter activity was performed to detect Per2-dLuc circadian oscillations...
2015: Chronobiology International
https://www.readbyqxmd.com/read/25613668/tm-233-a-novel-analog-of-1-acetoxychavicol-acetate-induces-cell-death-in-myeloma-cells-by-inhibiting-both-jak-stat-and-proteasome-activities
#12
Morihiko Sagawa, Takayuki Tabayashi, Yuta Kimura, Tatsuki Tomikawa, Tomoe Nemoto-Anan, Reiko Watanabe, Michihide Tokuhira, Masaki Ri, Yuichi Hashimoto, Shinsuke Iida, Masahiro Kizaki
Although the introduction of bortezomib and immunomodulatory drugs has led to improved outcomes in patients with multiple myeloma, the disease remains incurable. In an effort to identify more potent and well-tolerated agents for myeloma, we have previously reported that 1'-acetoxychavicol acetate (ACA), a natural condiment from South-East Asia, induces apoptotic cell death of myeloma cells in vitro and in vivo through inhibition of NF-κB-related functions. Searching for more potent NF-κB inhibitors, we developed several ACA analogs based on quantitative structure-activity relationship analysis...
April 2015: Cancer Science
https://www.readbyqxmd.com/read/25600438/requirement-for-innate-immunity-and-cd90%C3%A2-%C2%BA-nk1-1%C3%A2-lymphocytes-to-treat-established-melanoma-with-chemo-immunotherapy
#13
Marina Moskalenko, Michael Pan, Yichun Fu, Ellen H de Moll, Daigo Hashimoto, Arthur Mortha, Marylene Leboeuf, Padmini Jayaraman, Sebastian Bernardo, Andrew G Sikora, Jedd Wolchok, Nina Bhardwaj, Miriam Merad, Yvonne Saenger
We sought to define cellular immune mechanisms of synergy between tumor-antigen-targeted monoclonal antibodies and chemotherapy. Established B16 melanoma in mice was treated with cytotoxic doses of cyclophosphamide in combination with an antibody targeting tyrosinase-related protein 1 (αTRP1), a native melanoma differentiation antigen. We find that Fcγ receptors are required for efficacy, showing that antitumor activity of combination therapy is immune mediated. Rag1(-/-) mice deficient in adaptive immunity are able to clear tumors, and thus innate immunity is sufficient for efficacy...
March 2015: Cancer Immunology Research
https://www.readbyqxmd.com/read/25434696/how-do-we-understand-the-disagreement-in-the-frequency-of-surgical-site-infection-between-the-cdc-and-clavien-dindo-classifications
#14
Takanobu Yamamoto, Satoshi Takahashi, Koji Ichihara, Yoshiki Hiyama, Teruhisa Uehara, Jiro Hashimoto, Megumi Hirobe, Naoya Masumori
To clarify the discrepancy in the incidence and severity of surgical site infections (SSI) for radical cystectomy between reports based on the CDC guideline and those using the Clavien-Dindo classification we evaluated 449 consecutive patients who underwent radical cystectomy for bladder cancer between 1990 and 2012. Of the 115 (25.6%) patients with SSI defined by the CDC guideline, 89 could be analyzed. We compared the SSI rates and severity defined by the CDC guideline and Clavien-Dindo classifications. There were 58 patients with superficial SSI, 16 with deep SSI, and 15 with organ/space SSI according to the CDC guideline...
February 2015: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/25186928/reproductive-soldier-like-individuals-induced-by-juvenile-hormone-analog-treatment-in-zootermopsis-nevadensis-isoptera-archotermopsidae
#15
Ryota Saiki, Hajime Yaguchi, Yutaka Hashimoto, Souichirou Kawamura, Kiyoto Maekawa
Eusocial insects have highly sophisticated societies, showing a conspicuous division of labor associated with different phenotypes. These castes show specific morphologies adapted to discrete tasks. Termite castes are divided into reproductives, workers, and soldiers. Individuals with soldier-like heads as well as developed gonads have been recorded in several primitive families, and are called reproductive soldiers. In some termite species, however, a trade-off-like developmental relationship has been shown between soldier and imaginal characteristics...
September 2014: Zoological Science
https://www.readbyqxmd.com/read/25153584/subclinical-hypothyroidism-in-childhood-and-adolescense
#16
REVIEW
Gonul Catli, Ayhan Abaci, Atilla Büyükgebiz, Ece Bober
Subclinical hypothyroidism (SH) is defined as a serum thyroid-stimulating hormone (TSH) level above the reference range with normal serum free thyroxin (sT4) and free triiodothyronine (sT3) levels. The prevalence of SH in children and adolescents is reported between 1.7% and 9.5%. Hashimoto's thyroiditis is the most prevalent cause of SH in children. Although it has been suggested that SH is entirely an asymptomatic laboratory diagnosis, typical hypothyroid symptoms as well have been reported in some patients...
November 2014: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/25079471/cognitive-function-in-hashimoto-s-thyroiditis-under-levothyroxine-treatment
#17
Vaitsa Giannouli, Konstantinos A Toulis, Nikolaos Syrmos
UNLABELLED: ΟBJECTIVE: Although overt hypothyroidism has been documented as exerting detrimental effects on cognition and behavior, it remains controversial whether subclinical hypothyroidism or euthyroid patients with Hashimoto's thyroiditis (HT) under levothyroxine (LT4) treatment may experience any noticeable decline in cognitive function. PATIENTS: Two otherwise healthy, highly-functioning, first-degree relatives with a diagnosis of HT, under LT4 treatment for two years, were prospectively recruited into a clinical research study setting and followed for a year...
July 2014: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24756046/the-natural-course-of-hashimoto-s-thyroiditis-in-children-and-adolescents
#18
Hae Sang Lee, Jin Soon Hwang
OBJECTIVE: Hashimoto's thyroiditis (HT) is the most common cause of thyroid disease in children and adolescents, but little is known about the long-term follow-up of HT. The aim of this study was to analyze the clinical and laboratory characteristics and to observe the natural course of HT in children and adolescents. METHODS: We retrospectively reviewed 153 patients with HT diagnosed before 18 years of age. Subjects were grouped into euthyroid, subclinical hypothyroidism, overt hypothyroidism, and hyperthyroidism on the basis of the thyroid function test...
September 2014: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/24511040/symptomatic-intraosseous-lipoma-in-the-calcaneus
#19
Keiichi Muramatsu, Yasuhiro Tominaga, Takahiro Hashimoto, Toshihiko Taguchi
BACKGROUND: Intraosseous lipoma remains a poorly-characterized tumor. In paticular, the natural course of intracalcaneus lipoma after conservative treatment and the appropriate surgical modalities are still quite controversial. PATIENTS AND METHODS: We reviewed six symptomatic patients who underwent curettage of intracalcaneus lipoma followed by grafting of α- or β-tricalcium phosphate. An endoscopically-assisted technique was used in one case. RESULTS: All patients experienced heel pain that increased acutely after minor trauma...
February 2014: Anticancer Research
https://www.readbyqxmd.com/read/24266923/cytological-diagnosis-of-thyroid-nodules-in-hashimoto-thyroiditis-in-elderly-patients
#20
Alessia Caleo, Elena Vigliar, Mario Vitale, Vincenzo Di Crescenzo, Mariapia Cinelli, Chiara Carlomagno, Alfredo Garzi, Pio Zeppa
BACKGROUND: Long standing Hashimoto Thyroiditis (HT) causes shrinking and atrophy of the thyroid, but may also lead to diffuse enlargement of the gland and/or formation of nodules. These nodules should be differentiated from papillary thyroid carcinoma (PTC) and primary thyroidal non-Hodgkin lymphoma (PTL), which are possible complications of HT, and require pre-surgical diagnoses and different treatments. METHODS: Thirty-four elderly patients (≥ 65 yrs) with HT and diffuse or nodular enlargement of the thyroid underwent ultrasound (US)-guided FNC...
2013: BMC Surgery
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