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https://www.readbyqxmd.com/read/29045460/conjugated-nanoliposome-with-the-her2-neu-derived-peptide-gp2-as-an-effective-vaccine-against-breast-cancer-in-mice-xenograft-model
#1
Atefeh Razazan, Javad Behravan, Atefeh Arab, Nastaran Barati, Leila Arabi, Zahra Gholizadeh, Mahdi Hatamipour, Amin Reza Nikpoor, Amir Abbas Momtazi-Borojeni, Fatemeh Mosaffa, Mohamad Hosein Ghahremani, Mahmoud Reza Jaafari
One of the challenging issues in vaccine development is peptide and adjuvant delivery into target cells. In this study, we developed a vaccine and therapeutic delivery system to increase cytotoxic T lymphocyte (CTL) response against a breast cancer model overexpressing HER2/neu. Gp2, a HER2/neu-derived peptide, was conjugated to Maleimide-mPEG2000-DSPE micelles and post inserted into liposomes composed of DMPC, DMPG phospholipids, and fusogenic lipid dioleoylphosphatidylethanolamine (DOPE) containing monophosphoryl lipid A (MPL) adjuvant (DMPC-DMPG-DOPE-MPL-Gp2)...
2017: PloS One
https://www.readbyqxmd.com/read/29039120/differential-presentation-and-survival-of-de-novo-and-recurrent-metastatic-breast-cancer-over-time-1990-2010
#2
Judith A Malmgren, Musa Mayer, Mary K Atwood, Henry G Kaplan
BACKGROUND: Differences in de novo (dnMBC) and recurrent metastatic breast cancer (rMBC) presentation and survival over time have not been adequately described. METHODS: A retrospective cohort study, 1990-2010, with follow up through 2015 of dnMBC patients (stage IV at diagnosis) and rMBC patients with subsequent distant metastatic recurrence (stage I-III initial diagnosis) [dnMBC = 247, rMBC = 911)]. Analysis included Chi squared tests of categorical variables, Kaplan-Meier survival estimates, and Cox proportional adjusted hazard ratios (HzR) and 95% confidence intervals (CI)...
October 16, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29037894/indentation-mapping-reveals-poroelastic-but-not-viscoelastic-properties-spanning-native-zonal-articular-cartilage
#3
Joseph A Wahlquist, Frank W DelRio, Mark A Randolph, Aaron H Aziz, Chelsea M Heveran, Stephanie J Bryant, Corey P Neu, Virginia L Ferguson
Osteoarthrosis is a debilitating disease affecting millions, yet engineering materials for cartilage regeneration has proven difficult because of the complex microstructure of this tissue. Articular cartilage, like many biological tissues, produces a time-dependent response to mechanical load that is critical to cell's physiological function in part due to solid and fluid phase interactions and property variations across multiple length scales. Recreating the time-dependent strain and fluid flow may be critical for successfully engineering replacement tissues but thus far has largely been neglected...
October 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29033361/binding-of-pld2-generated-phosphatidic-acid-to-kif5b-promotes-mt1-mmp-surface-trafficking-and-lung-metastasis-of-mouse-breast-cancer-cells
#4
Ziqing Wang, Feng Zhang, Jingquan He, Ping Wu, Li Wei Rachel Tay, Ming Cai, Weiqi Nian, Yuanyuan Weng, Li Qin, Jeffrey T Chang, Laura B McIntire, Gilbert Di Paolo, Jianming Xu, Junmin Peng, Guangwei Du
Little is known about the cellular events promoting metastasis. We show that knockout of phospholipase D2 (PLD2), which generates the signaling lipid phosphatidic acid (PA), inhibits lung metastases in the mammary tumor virus (MMTV)-Neu transgenic mouse breast cancer model. PLD2 promotes local invasion through the regulation of the plasma membrane targeting of MT1-MMP and its associated invadopodia. A liposome pull-down screen identifies KIF5B, the heavy chain of the motor protein kinesin-1, as a new PA-binding protein...
October 11, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29032020/long-term-impact-of-suboptimal-rotavirus-vaccines-on-acute-gastroenteritis-in-hospitalized-children-in-northern-taiwan
#5
Wan-Ju Yu, Shih-Yen Chen, Chi-Neu Tsai, Hsun-Ching Chao, Man-Shan Kong, Yi-Jung Chang, Cheng-Hsun Chiu
BACKGROUND/PURPOSE: Rotavirus vaccines were launched in Taiwan since early 2006. Our study was aimed to figure out long-term extended molecular epidemiology in acute gastroenteritis (AGE) in hospitalized young children after rotavirus vaccination in Taiwan. METHODS: During the 10-year period from January 2007 to December 2016, fecal samples from children under 5 years old with AGE hospitalized in Chang Gung Children's Hospital (CGCH) were examined for enteric pathogens and they were divided into two time intervals: early post-vaccine (Jan...
October 11, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29029971/das-stepped-wedge-design-stufenlos-regelbar
#6
EDITORIAL
Juliane Köberlein-Neu, Falk Hoffmann
No abstract text is available yet for this article.
October 10, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29027290/pertuzumab-and-trastuzumab-infusion-related-cytokine-release-syndrome-in-a-chemotherapy-naive-patient-with-metastatic-breast-cancer
#7
Adonice Khoury, Vikas Parihar, Lillie O'steen, Kartikeya Cherabuddi
Pertuzumab is a monoclonal antibody that targets and down regulates HER-2/neu expression in ductal breast tumors. Other HER-2/neu monoclonal antibodies, particularly trastuzumab, have been implicated to induce infusion related reactions such as cytokine release syndrome (CRS). Here, we report a case of pertuzumab associated CRS prior to infusion of trastuzumab which warranted hospitalization for symptom management.
October 13, 2017: Breast Journal
https://www.readbyqxmd.com/read/29017668/frequency-of-her2-neu-protein-expression-in-ovarian-epithelial-cancers
#8
Anum Jafri, Sarwat Rizvi
OBJECTIVE: To detect the frequency of Her-2/neu protein expression in epithelial ovarian cancers by immunohistochemistry. STUDY DESIGN: Descriptive cross-sectional study. PLACE AND DURATION OF STUDY: Department of Pathology, King Edward Medical University, Lahore, from July 2014 to May 2015. METHODOLOGY: Fifty-six cases diagnosed as epithelial ovarian cancer on histopathology were included in this study. Immunohistochemistry was performed to observe the pattern of HER2/neu protein expression in these cases...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28993342/in-vivo-detection-of-hsp90-identifies-breast-cancers-with-aggressive-behavior
#9
Takuya Osada, Kensuke Kaneko, William R Gwin, Michael A Morse, Amy Hobeika, Brian W Pogue, Zachary C Hartman, Philip F Hughes, Timothy Haystead, H Kim Lyerly
PURPOSE: Heat shock protein 90 (Hsp90), a chaperone to numerous molecular pathways in malignant cells, is elevated in aggressive breast cancers (BC). We hypothesized that identifying breast cells with elevated Hsp90 activity in situ could result in early detection of aggressive BC. EXPERIMENTAL DESIGN: We exploited the uptake of a Hsp90 inhibitor by malignant cells to create an imaging probe (HS131) of Hsp90 activity by linking it to a near infrared (nIR) dye. HS131 uptake into cells correlated with cell membrane expression of Hsp90 and was used to image molecular subtypes of murine and human BC in vitro and in murine models...
October 9, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28989584/expression-analysis-of-long-non-coding-pcat-1in-breast-cancer
#10
Shaghayegh Sarrafzadeh, Lobat Geranpayeh, Soudeh Ghafouri-Fard
Background: The prostate cancer-associated non-coding RNA transcript 1 (PCAT-1) is a newly identified long non- coding RNA whose participation in tumorigenesis of a variety of cancers has been observed. In the present study, we aimed at analysis of its expression in breast cancer patients. Materials and Methods: The expression of PCAT-1 was assessed using real-time reverse transcription polymerase chain reaction in tumor samples obtained from 47newly diagnosed breast cancer patients as well as their corresponding adjacent non-cancerous tissues (ANCTs)...
July 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28982115/tlr4-as-a-negative-regulator-of-keratinocyte-proliferation
#11
Guergana Iotzova-Weiss, Sandra N Freiberger, Pål Johansen, Jivko Kamarachev, Emmanuella Guenova, Piotr J Dziunycz, Guillaume A Roux, Johannes Neu, Günther F L Hofbauer
TLR4 is an innate immune receptor with expression in human skin, keratinocytes as well as squamous cell carcinoma (SCC) of the skin. In the present study we investigate the role of TLR4 as a negative regulator of keratinocyte proliferation. We present here that the expression of TLR4 increased with the differentiation of cultured keratinocytes in a passage-dependent manner or under calcium-rich conditions. Moreover, the down-regulation of TLR4 by specific knockdown increased the proliferation of HaCaT keratinocytes in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28981525/a-draft-genome-sequence-of-the-rose-black-spot-fungus-diplocarpon-rosae-reveals-a-high-degree-of-genome-duplication
#12
Enzo Neu, Jonathan Featherston, Jasper Rees, Thomas Debener
BACKGROUND: Black spot is one of the most severe and damaging diseases of garden roses. We present the draft genome sequence of its causative agent Diplocarpon rosae as a working tool to generate molecular markers and to analyze functional and structural characteristics of this fungus. RESULTS: The isolate DortE4 was sequenced with 191x coverage of different read types which were assembled into 2457 scaffolds. By evidence supported genome annotation with the MAKER pipeline 14,004 gene models were predicted and transcriptomic data indicated that 88...
2017: PloS One
https://www.readbyqxmd.com/read/28978097/human-her2-overexpressing-mouse-breast-cancer-cell-lines-derived-from-mmtv-f-huher2-mice-characterization-and-use-in-a-model-of-metastatic-breast-cancer
#13
Sunju Park, Jessie R Nedrow, Anders Josefsson, George Sgouros
Preclinical evaluation of therapeutic agents against metastatic breast cancer require cell lines and animal models that recapitulate clinical metastatic breast cancer as much as possible. We have previously used cell lines derived from the neu-N transgenic model to investigate anti-neu targeting of metastatic breast cancer using an alpha-emitter labeled antibody reactive with the rat variant of HER2/neu expressed by the neu-N model. To investigate alpha-particle emitter targeting of metastatic breast cancer using clinically relevant, commercially available anti-HER2/neu antibodies, we have developed cell lines derived from primary tumors and lung metastases from HuHER2 transgenic mice...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28978092/native-glycan-fragments-detected-by-maldi-ft-icr-mass-spectrometry-imaging-impact-gastric-cancer-biology-and-patient-outcome
#14
Thomas Kunzke, Benjamin Balluff, Annette Feuchtinger, Achim Buck, Rupert Langer, Birgit Luber, Florian Lordick, Horst Zitzelsberger, Michaela Aichler, Axel Walch
Glycosylation in cancer is a highly dynamic process that has a significant impact on tumor biology. Further, the attachment of aberrant glycan forms is already considered a hallmark of the disease state. Mass spectrometry has become a prominent approach to analyzing glycoconjugates. Specifically, matrix-assisted laser desorption/ionisation -mass spectrometric imaging (MALDI-MSI) is a powerful technique that combines mass spectrometry with histology and enables the spatially resolved and label-free detection of glycans...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28973704/neoadjuvant-and-adjuvant-therapies-for-breast-cancer
#15
REVIEW
Susmitha Apuri
Breast cancer remains the most common cancer in women in the United States, the second most common cause of cancer death, and the main cause of death in women ages 45 to 55 years. Molecular analyses have shown that breast cancer is divided into several subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 [HER2] enriched, and basal-like), based on microarray techniques. Patients diagnosed as having breast cancer may undergo adjuvant or neoadjuvant chemotherapy, depending on the tumor size, hormone receptor, HER2/neu status, and desire for breast preservation...
October 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28972792/a-nano-liposome-vaccine-carrying-e75-a-her-2-neu-derived-peptide-exhibits-significant-anti-tumor-activity-in-mice
#16
Atefeh Arab, Javad Behravan, Atefeh Razazan, Zahra Gholizadeh, Amin Reza Nikpoor, Nastaran Barati, Fatemeh Mosaffa, Ali Badiee, Mahmoud Reza Jaafari
E75 (HER-2/neu-369-377), is an immunogenic peptide which is highly expressed in breast cancer patients. The purpose of this study was to develop an effective vaccine delivery/adjuvant system by attachment of this peptide to the surface of liposomes consisting of phospholipids including DSPC and DSPG with high transition temperature (Tm) and DOPE (a pH-sensitive lipid for cytosolic antigen delivery) to improve anti-tumor immune activity against the E75 peptide. For this purpose, the E75 peptide was incorporated into liposomes consisting of DSPC/DSPG/Chol/DOPE (15/2/3/5 molar ratio) through conjugation with maleimide-PEG2000-DSPE...
October 3, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28968647/genetic-deletion-of-sphingosine-kinase-1-suppresses-mouse-breast-tumor-development-in-a-her2-transgenic-model
#17
Yoshiko Shimizu, Hideki Furuya, Paulette M Tamashiro, Kayoko Iino, Owen T M Chan, Steve Goodison, Ian Pagano, Kanani Hokutan, Rafael Peres, Lenora W M Loo, Brenda Hernandez, Aung Naing, Clayton D K Chong, Charles J Rosser, Toshihiko Kawamori
Aberrant sphingolipid metabolism has been reported to promote breast cancer progression. Sphingosine kinase 1 (SphK1) is a key metabolic enzyme for the formation of pro-survival S1P from pro-apoptotic ceramide. The role of SphK1 in breast cancer has been well studied in estrogen receptor (ER)-positive breast cancer, however, its role in human epidermal growth factor 2 (HER2)-positive breast cancer remains unclear. Here we show that genetic deletion of SphK1 significantly reduced mammary tumor development with reduced tumor incidence and multiplicity in the MMTV-neu transgenic mouse model...
September 11, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28967645/association-of-cd44-cd24-low-with-markers-of-aggressiveness-and-plasticity-of-cell-lines-and%C3%A2-tumors-of-patients-with-breast-cancer
#18
V F Chekhun, N Y Lukianova, S V Chekhun, N O Bezdieniezhnykh, T V Zadvorniy, T V Borikun, L Z Polishchuk, O М Klyusov
AIM: To search for additional molecular-biological markers of cancer stem cell (CSC) involved in the development of intra-tumor heterogeneity for the detection of features of the breast cancer (BC) pathogenesis. MATERIALS AND METHODS: Expression of estrogen receptors (ER), progesterone receptors (PR), Her2/neu, E- and N-cadherin, CD24, CD44, Bcl-2, Bax, Slug, P-gp, glutathione-S-transferase (GST) and metallothionein in cell lines was determined by the immunocytochemical method...
September 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28966661/the-strength-of-the-meridional-overturning-circulation-of-the-stratosphere
#19
Marianna Linz, R Alan Plumb, Edwin P Gerber, Florian J Haenel, Gabriele Stiller, Douglas E Kinnison, Alison Ming, Jessica L Neu
The distribution of gases such as ozone and water vapour in the stratosphere - which affect surface climate - is influenced by the meridional overturning of mass in the stratosphere, the Brewer-Dobson circulation. However, observation-based estimates of its global strength are difficult to obtain. Here we present two calculations of the mean strength of the meridional overturning of the stratosphere. We analyze satellite data that document the global diabatic circulation between 2007- 2011, and compare these to three re-analysis data sets and to simulations with a state-of-the-art chemistry-climate model...
September 2017: Nature Geoscience
https://www.readbyqxmd.com/read/28965621/expression-of-prb-ki67-and-her-2-neu-in-gastric-carcinomas-relation-to-different-histopathological-grades-and-stages
#20
Azza Abdel-Aziz, Rehab Allah Ahmed, Afaf Taha Ibrahiem
Gastric carcinoma is one of the aggressive malignancies with poor prognosis. The expression of pRb, Ki67, Her-2 in relation to tumor grade and stage in gastric carcinoma still needs more exploration. This study was performed aiming to study the immunohistochemical expression of altered retinoblastoma encoding protein (pRb), Ki67 and Her-2 in gastric carcinoma and to investigate their clinical and pathological significance. We studied tumor tissue specimens from 48 patients with gastric carcinoma. Paraffin sections were submitted for immunohistochemistry using pRb, Ki67 and Her-2...
October 2017: Annals of Diagnostic Pathology
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