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https://www.readbyqxmd.com/read/29652213/ovarian-reserve-in-young-juvenile-idiopathic-arthritis-patients
#1
Gabriela R V Ferreira, Renato B Tomioka, Nadia E Aikawa, Elaine P Leon, Gustavo A R Maciel, Paulo C Serafini, Edmund C Baracat, Claudia Goldenstein-Schainberg, Rosa M R Pereira, Eloisa Bonfá, Clovis A Silva
OBJECTIVES: Juvenile idiopathic arthritis (JIA) occurs during reproductive age, however, there are not systematic data regarding ovarian function in this disease. METHODS: Twenty-eight post-pubertal JIA patients and age-matched 28 healthy controls were studied. Complete ovarian function was assessed during the early follicular phase of the menstrual cycle including anti-Müllerian hormone (AMH), estradiol, luteinizing hormone (LH), follicle stimulating hormone (FSH) and antral follicle count (AFC) by ovarian ultrasound, and anti-corpus lutheum antibodies (anti-CoL)...
April 13, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29644764/effect-of-simultaneously-started-clomiphene-citrate-and-gonadotropins-in-antagonist-regimes-on-cumulative-live-births-fresh-cycle-live-births-and-cost-of-stimulation-in-ivf-cycles
#2
Ruma Satwik, Mohinder Kochhar
AIM: The aim of the study was to compare simultaneously started clomiphene citrate (CC) and gonadotropins (Gn) with gonadotropins alone in conventional antagonist regimes with respect to fresh-cycle live births, cumulative live births and cost of ovarian stimulation per started cycle. METHODS: This was a single-center prospective cohort study conducted over 1 year. Women undergoing autologous in vitro fertilization (IVF) treatment in antagonist protocols and who consented to participate in the study were divided into two cohorts...
April 11, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29627845/eicosapentaenoic-acid-improves-polycystic-ovary-syndrome-in-rats-via-sterol-regulatory-element-binding-protein-1-srebp-1-toll-like-receptor-4-tlr4-pathway
#3
Yanting Wang, Jinying He, Jing Yang
BACKGROUND This study aimed to investigate the protective effect of eicosapentaenoic acid (EPA) on rats with polycystic ovary syndrome (PCOS). MATERIAL AND METHODS Rats with PCOS were intraperitoneally injected with different doses of EPA. Levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) were measured using corresponding kits. HE staining was used to observe lesions in ovarian tissue. Levels of inflammatory factors in ovarian tissue of rats were detected by ELISA...
April 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29627420/exercise-training-causes-a-partial-improvement-through-increasing-testosterone-and-enos-for-erectile-function-in-middle-aged-rats
#4
Dae Yun Seo, Sung Ryul Lee, Hyo Bum Kwak, Hyuntea Park, Kyo Won Seo, Yeon Hee Noh, Kang-Moon Song, Ji-Kan Ryu, Kyung Soo Ko, Byoung Doo Rhee, Jin Han
PURPOSE: Aging changes the balance of sex hormones and causes endothelial dysfunction in the penis, both of which are important determinants of erectile dysfunction (ED). The purpose of this study was to evaluate whether exercise training could protect against erectile dysfunction by increasing serum testosterone and penile eNOS levels in aging rats. METHODS: A total of 14 young (2-month-old) and 14 middle-aged (18-month-old) Sprague Dawley rats were randomly assigned to either untrained control (young control, [YC], middle-aged control, [MC]) or endurance exercise-trained (young exercise, [YE], middle-aged exercise, [ME]) groups with seven rats per group...
April 5, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29626103/role-of-rab5a-in-fshr-mediated-signal-transduction-in-human-granulosa-cells
#5
Kai Zhu, Shang Li, Jiansheng Liu, Yan Hong, Zi-Jiang Chen, Yanzhi Du
Polycystic ovary syndrome, a common condition characterized by endocrine dysfunction, menstrual irregularity, anovulation, and polycystic ovaries, affects 5%-7% of reproductive-age women. RAB5B, which is identified by a genome-wide association study as a risk locus for this syndrome, encodes a small GTPase involved in control of receptor internalization and early endosome fusion. We found that RAB5A mRNA levels in luteinized granulosa cells of obese patients with polycystic ovary syndrome were lower than in those of obese women without the syndrome...
April 6, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29625802/cryosurvival-of-rabbit-embryos-obtained-after-superovulation-with-corifollitropin-alfa-with-or-without-lh
#6
José Salvador Vicente, María Pilar Viudes-de-Castro, José Isaí Cedano-Castro, Francisco Marco-Jiménez
The efficiency of an embryo bank depends on provision of optimal conditions for recovery, cryopreservation and transfer to a breed or strain. In this sense, increasing the number of embryos available using superovulation should improve the cryobank efficiency. However, vagueness of response to conventional protocols to control or increase ovarian response and the quality of oocytes and embryos and their cryotolerance remain a challenge. The aim of our study was to evaluate the effect of corifollitropin alpha (CTP) and a recombinant human FSH (rhFSH), alone or supplemented with rhLH, on embryo cryosurvival by in vitro development and OCT4 and NANOG mRNA abundance at blastocyst stage and offspring rate...
March 31, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29611661/evaluation-of-luteinizing-hormone-regulation-of-maturation-and-apoptosis-expression-of-lhr-and-fshr-in-cumulus-oocyte-complexes-in-lanzhou-fat-tailed-sheep
#7
S C Wei, Y Y Deng, L J Lai, H Q Liang, G Z Lin, Z D Gong
The present study aimed to assess LH effects on in vitro maturation (IVM) and apoptosis and also to explore the gene expressions of LHR and FSHR in cumulus-oocyte complexes (COCs) of the sheep. COCs were in vitro matured 24h in the IVM medium supplemented with varying concentrations of LH (0, 5, 10, 20 and 30 μg/mL). They were allocated into LH-1 (control group), LH-2, LH-3, LH-4 and LH-5 groups, respectively. FSH (10 IU/mL) addition was as a positive control (FSH group). COCs apoptosis was assessed by TUNEL...
December 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29610059/gonadotropin-concentrations-associated-with-variations-in-diameter-deviation-during-follicle-selection-in-holstein-heifers
#8
O J Ginther, R R Domingues, S V Dangudubiyyam, E R Araujo
Diameter deviation or selection of the future dominant follicle (F1) from the future largest subordinate follicle (F2) during a follicular wave occurs when F1 is 8.5 mm (expected deviation, day 0). Deviation has been classified as conventional (F2 ≥ 7.0 mm), F2-undersized (F2 < 7.0 mm), and F1,F2-switched (F2 larger than F1 on day -1 or 0). Concentrations of gonadotropins were compared within and among deviation classifications in waves 1 and 2 in 48 heifers. A three-way (wave 1 compared with 2, classification, day) analysis indicated no effect of wave 1 compared with 2 on F2 or FSH...
March 26, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29606625/s-nitrosoglutathione-reductase-gsnor-deficiency-results-in-secondary-hypogonadism
#9
Thomas A Masterson, Himanshu Arora, Shathiyah Kulandavelu, Rona S Carroll, Ursula B Kaiser, Sakir H Gultekin, Joshua M Hare, Ranjith Ramasamy
BACKGROUND: Excess reactive oxygen species and reactive nitrogen species are implicated in male infertility and impaired spermatogenesis. AIM: To investigate the effect of excess reactive nitrogen species and nitrosative stress on testicular function and the hypothalamic-pituitary-gonadal axis using the S-nitrosoglutathione reductase-null (Gsnor-/- ) mouse model. METHODS: Testis size, pup number, and epididymal sperm concentration and motility of Gsnor-/- mice were compared with those of age-matched wild-type (WT) mice...
March 29, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29603520/effect-of-pomegranate-extract-on-vagina-skeleton-metabolic-and-endocrine-profiles-in-an-ovariectomized-rat-model
#10
Isik Kaban, Alpaslan Kaban, Aysun F Tunca, Nurettin Aka, Hacer Kavak, Fugen Akar
AIM: Many women need estrogen therapy because of menopausal complaints. It is suggested that pomegranate plant has estrogenic effect. Aim of the study was to examine the effects of pomegranate seed extract on menopausal changes. METHODS: This study was conducted in an experimental environment with 23 Wistar Albino genus female rats. Sixteen rats were divided into two groups after ovariectomy. One group (SG) was fed with standard food and the pomegranate extract was added to drinking water of the other group (PG)...
March 30, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29579710/bu-shen-zhu-yun-decoction-promotes-synthesis-and-secretion-of-fsh%C3%AE-and-lh%C3%AE-in-anterior-pituitary-cells-in-vitro
#11
Xiaofei Jiang, Huifang Zhou, Mingqing Shi, Boru Zhou, Bei Liu, Yizhen Yuan, Jinjun Shan, Jianya Xu, Tong Xie
Luteal phase defects (LPD) are an important etiology of infertility which has increased in recent years. Studies have shown that bu-shen-zhu-yun decoction (BSZY-D) can lower the expression of estrogen receptor and progesterone receptor, in rats endometrium of embryonic implantation period, which upregulated by mifepristone, and improve uterine receptivity. The aim of present study was to determine the effect of BSZY-D on the synthesis and secretion of gonadotropic hormones in the anterior pituitary cells of rats...
March 23, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29568885/role-of-leptin-and-the-leptin-receptor-in-the-pathogenesis-of-varicocele-induced-testicular-dysfunction
#12
Jie Zhang, Peng-Peng Jin, Min Gong, Qing-Tong Yi, Ru-Jian Zhu
The present study investigated the expression of leptin and its receptor in the left testis and hypothalamus of rats with varicocele and clarified their roles in the pathogenesis of varicocele‑induced testicular dysfunction. A total of 40 male rats were divided randomly into four groups. Groups 1 (G1) and 3 (G3) underwent a sham operation. Groups 2 (G2) and 4 (G4) underwent operations to form a varicocele created by partial ligation of the left renal vein. G1 and G2 rats were euthanized 4 weeks after the operation while G3 and G4 rats were euthanized at 8 weeks...
March 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29558207/low-dose-brain-estrogen-prevents-menopausal-syndrome-while-maintaining-the-diversity-of-the-gut-microbiomes-in-estrogen-deficient-rats
#13
Sunmin Park, Da Sol Kim, Eun Seon Kang, Da Bin Kim, Suna Kang
We evaluated the effects of intracerebroventricular administration(ICV) of brain estrogen and progesterone on menopausal symptoms and their effects on the secretion of follicle-stimulating hormone(FSH) and luteinizing hormone(LH) in estrogen-deficient rats. Three weeks after ovariectomy(OVX) or Sham-operation, OVX rats were given ICV infusions of either 17β-estradiol(4 μg/day; ICV-E), progesterone(0.8 μg/day; ICV-P), or vehicle(control) for 4 weeks. OVX rats in the positive-control group were orally provided 150 μg 17β-estradiol/kg bw/day...
March 20, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29546361/single-embryo-transfer-by-day-3-time-lapse-selection-versus-day-5-conventional-morphological-selection-a-randomized-open-label-non-inferiority-trial
#14
Lanlin Yang, Sufen Cai, Shuoping Zhang, Xiangyi Kong, Yifan Gu, Changfu Lu, Jing Dai, Fei Gong, Guangxiu Lu, Ge Lin
STUDY QUESTION: Does single cleavage-stage (Day 3) embryo transfer using a time-lapse (TL) hierarchical classification model achieve comparable ongoing pregnancy rates (OPR) to single blastocyst (Day 5) transfer by conventional morphological (CM) selection? SUMMARY ANSWER: Day 3 single embryo transfer (SET) with a hierarchical classification model had a significantly lower OPR compared with Day 5 SET with CM selection. WHAT IS KNOWN ALREADY: Cleavage-stage SET is an alternative to blastocyst SET...
March 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29534229/ceramide-1-phosphate-has-protective-properties-against-cyclophosphamide-induced-ovarian-damage-in-a-mice-model-of-premature-ovarian-failure
#15
Natalia Pascuali, Leopoldina Scotti, Mariana Di Pietro, Gonzalo Oubiña, Diana Bas, María May, Antonio Gómez Muñoz, Patricia S Cuasnicú, Débora J Cohen, Marta Tesone, Dalhia Abramovich, Fernanda Parborell
STUDY QUESTION: Is ceramide-1-phosphate (C1P) an ovarian protective agent during alkylating chemotherapy? SUMMARY ANSWER: Local administration of C1P drastically reduces ovarian damage induced by cyclophosphamide (Cy) via protection of follicular reserve, restoration of hormone levels, inhibition of apoptosis and improvement of stromal vasculature, while protecting fertility, oocyte quality and uterine morphology. WHAT IS KNOWN ALREADY: Cancer-directed therapies cause accelerated loss of ovarian reserve and lead to premature ovarian failure (POF)...
March 9, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29524809/anti-m%C3%A3-llerian-hormone-and-antral-follicle-count-are-more-effective-for-selecting-ewes-with-good-potential-for-in-vivo-embryo-production-than-the-presence-of-fecg-e-mutation-or-ecg-pre-selection-tests
#16
Pedro Henrique Nicolau Pinto, Mario Felipe Alvarez Balaro, Joanna Maria Gonçalves Souza-Fabjan, Lilian Dos Santos Ribeiro, Gláucia Mota Bragança, Ceci Ribeiro Leite, Eduardo Kenji Nunes Arashiro, Kleibe de Moraes Silva, Jeferson Ferreira Da Fonseca, Felipe Zandonadi Brandão
This study aims to compare four different methods for selecting high responding sheep donors for in vivo embryo production. These methods include a pre-selection eCG test (eCG), antral follicle count (AFC), plasma anti-Müllerian hormone measurement (AMH) and genotyping for the presence of the FecGE mutation (a polymorphism in the GDF9 gene associated with increased ovulation rate). Santa Ines ewe lambs (n = 25) underwent superovulation (SOV) with 800 IU equine chorionic gonadotropin (eCG) and the corpus luteum (CL) count was recorded by laparoscopy after eight days...
February 23, 2018: Theriogenology
https://www.readbyqxmd.com/read/29517803/thyroid-hormones-and-menstrual-cycle-function-in-a-longitudinal-cohort-of-premenopausal-women
#17
Melanie H Jacobson, Penelope P Howards, Lyndsey A Darrow, Juliana W Meadows, James S Kesner, Jessica B Spencer, Metrecia L Terrell, Michele Marcus
BACKGROUND: Previous studies have reported that hyperthyroid and hypothyroid women experience menstrual irregularities more often compared with euthyroid women, but reasons for this are not well-understood and studies on thyroid hormones among euthyroid women are lacking. In a prospective cohort study of euthyroid women, this study characterised the relationship between thyroid hormone concentrations and prospectively collected menstrual function outcomes. METHODS: Between 2004-2014, 86 euthyroid premenopausal women not lactating or taking hormonal medications participated in a study measuring menstrual function...
March 8, 2018: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29514896/semen-quality-in-patients-with-pituitary-disease-and-adult-onset-hypogonadotropic-hypogonadism
#18
Mikkel Andreassen, Anders Juul, Ulla Feldt-Rasmussen, Niels Joergensen
Gonadotropins (luteinizing hormone (LH) and follicle stimulating hormone (FSH)) are released from the pituitary gland and stimulate Leydig cells to produce testosterone and initiates spermatogenesis. Little is known about how and when the deterioration of semen quality occurs in patients with adult onset gonadotropin insufficiency Design and methods: A retrospective study comprising 20 testosterone deficient men (median age 29 years) with acquired pituitary disease, who delivered semen for cryopreservation before initiation of testosterone therapy...
March 7, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29506861/prospective-assessment-of-follicular-growth-and-the-oocyte-cohort-after-ovarian-stimulation-for-fertility-preservation-in-90-cancer-patients-versus-180-matched-controls
#19
Christine Decanter, Geoffroy Robin, Audrey Mailliez, Julien Sigala, Franck Morschhauser, Nassima Ramdane, Patrick Devos, Didier Dewailly, Brigitte Leroy-Martin, Laura Keller
A lower number of metaphase II oocytes eligible for vitrification after controlled stimulation in cancer patients has recently been reported, suggesting that cancer may impair the dynamics and quality of follicular growth. In this prospective, non-interventional study, the pattern of follicular growth and oocyte cohort after ovarian stimulation in cancer patients was analysed. Ninety cancer patients, recruited before starting chemotherapy, were compared with 180 time- and age-matched healthy controls undergoing intracytoplasmic sperm injection...
February 19, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29498933/management-of-women-with-pcos-using-myo-inositol-and-folic-acid-new-clinical-data-and-review-of-the-literature
#20
Pedro-Antonio Regidor, Adolf Eduard Schindler, Bernd Lesoine, Rene Druckman
Introduction The use of 2 × 2000 mg myo-inositol +2 × 200 μg folic acid per day is a safe and promising tool in the effective improvement of symptoms and infertility for patients with polycystic ovary syndrome (PCOS). In addition, PCOS is one of the pathological factors involved in the failure of in vitro fertilization (IVF). Typically, PCOS patients suffer of poor quality oocytes. Patients and methods In an open, prospective, non-blinded, non-comparative observational study, 3602 infertile women used myo-inositol and folic acid between 2 and 3 months in a dosage of 2 × 2000 mg myo-inositol +2 × 200 μg folic acid per day...
March 2, 2018: Hormone Molecular Biology and Clinical Investigation
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