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https://www.readbyqxmd.com/read/27910716/persistent-amenorrhea-and-decreased-dheas-to-cortisol-ratio-after-recovery-from-anorexia-nervosa
#1
Alessandra Andrisani, Chiara Sabbadin, Silvia Minardi, Angela Favaro, Gabriella Donà, Luciana Bordin, Guido Ambrosini, Decio Armanini
Persistent amenorrhea is a frequent condition affecting anorexic patients after stable weight recovery. It has been proposed that it could be due to alterations of the hypothalamic-pituitary-gonadal axis linked with persistent hormonal impairments, such as relative hypercortisolemia and hypoleptinemia, and psychological symptoms related to anorexia nervosa (AN). The aim of our study was to evaluate the metabolic and hormonal pattern involved in the persistence of amenorrhea after recovery from AN. Eight weight-recovered anorexic patients with amenorrhea were investigated and matched with 10 healthy eumenorrhoic women, comparable for age and BMI...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27894163/feature-of-amenorrhea-in-postoperative-tamoxifen-users-with-breast-cancer
#2
Hoon Kim, Wonshik Han, Seung Yup Ku, Chang Suk Suh, Seok Hyun Kim, Young Min Choi
OBJECTIVE: Tamoxifen has been used to prevent the recurrence of breast cancer. However, tamoxifen-users frequently experience amenorrhea and it can be confused from that caused by other hormonal abnormalities. In amenorrheic patients without breast cancer, clinicians usually measure the sex hormone levels that are known to be associated with ovarian or menstrual function. This study aimed to investigate the feature of female sex hormones in premenopausal breast cancer patients undergoing tamoxifen treatment...
October 27, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27893825/low-birth-weight-is-associated-with-a-decreased-overall-adult-health-status-and-reproductive-capability-results-of-a-cross-sectional-study-in-primary-infertile-patients
#3
Luca Boeri, Eugenio Ventimiglia, Paolo Capogrosso, Silvia Ippolito, Angela Pecoraro, Marco Paciotti, Roberta Scano, Alessandro Galdini, Luca Valsecchi, Enrico Papaleo, Francesco Montorsi, Andrea Salonia
Individuals born with low birth weight (LBW) risk cardiometabolic complications later in life. However the impact of LBW on general health status and male reproductive function has been scantly analysed. We investigated the clinical and seminal impact of different birth weights (BW) in white-European men presenting for primary couple's infertility. Demographic, clinical, and laboratory data from 827 primary infertile men were compared with those of 373 consecutive fertile men. Patients with BW ≤2500, 2500-4200, and ≥4200gr were classified as having LBW, normal (NBW), and high BW (HBW), respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27889471/functional-characterization-of-two-naturally-occurring-mutations-v-221-g-and-t-449-n-in-the-follicle-stimulating-hormone-receptor
#4
Antara A Banerjee, Swati K Achrekar, Shaini Joseph, Bhakti R Pathak, Smita D Mahale
Naturally occurring mutations in follicle stimulating hormone receptor (FSHR) affect the receptor function. Here, we characterized two such previously reported mutations, V(221)G and T(449)N, in the extracellular domain and transmembrane helix 3, of FSHR, respectively. Functional studies with the V(221)G mutant demonstrated an impairment in FSH binding and signaling. Validation of X-ray crystallography data indicating the contribution of FSHR specific residues in the vicinity of V(221) to contribute to FSH-FSHR interaction was carried out...
November 23, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27871199/influence-of-obesity-and-hormone-disturbances-on-sexuality-of-women-in-the-menopause
#5
Aleksandra Simoncig Netjasov, Milina Tančić-Gajić, Miomira Ivović, Ljiljana Marina, Zorana Arizanović, Svetlana Vujović
OBJECTIVE: To assess influence of obesity and hormone disturbances on sexuality in the menopause. METHODS: The study included 73 menopausal women, who were divided into groups according to body mass index (BMI) ≥ 26.7 kg/m(2). Anthropometric characteristics and blood pressure were measured. Blood was taken at 08:00 for hormones. All the participants filled in McCoy Female Sexual Questionnaire for the assessment of sexual life. STATISTICS: Student's t-test, correlation, analysis of variance (ANOVA)...
September 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27836979/a-mild-ovarian-stimulation-strategy-in-women-with-poor-ovarian-reserve-undergoing-ivf-a-multicenter-randomized-non-inferiority-trial
#6
M A Youssef, M van Wely, H Al-Inany, T Madani, N Jahangiri, S Khodabakhshi, M Alhalabi, M Akhondi, S Ansaripour, R Tokhmechy, L Zarandi, A Rizk, M El-Mohamedy, E Shaeer, M Khattab, M H Mochtar, F van der Veen
STUDY QUESTION: In subfertile women with poor ovarian reserve undergoing IVF does a mild ovarian stimulation strategy lead to comparable ongoing pregnancy rates in comparison to a conventional ovarian stimulation strategy? SUMMARY ANSWER: A mild ovarian stimulation strategy in women with poor ovarian reserve undergoing IVF leads to similar ongoing pregnancy rates as a conventional ovarian stimulation strategy. WHAT IS KNOWN ALREADY: Women diagnosed with poor ovarian reserve are treated with a conventional ovarian stimulation strategy consisting of high-dose gonadotropins and pituitary downregulation with a long mid-luteal start GnRH-agonist protocol...
November 11, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27831635/short-gonadotropin-releasing-hormone-agonist-versus-flexible-antagonist-versus-clomiphene-citrate-regimens-in-poor-responders-undergoing-in-vitro-fertilization-a-randomized-controlled-trial
#7
M Schimberni, F Ciardo, M Schimberni, A Giallonardo, V De Pratti, M Sbracia
OBJECTIVE: Poor responders represent a frustrating condition for couples undergoing IVF and clinicians, and their treatment remains disputed. To assess the efficacy and the most suitable protocol, we conducted a randomized controlled trial comparing three different protocols of ovarian stimulation in poor responder women: clomiphene citrate (CC) plus a high dose of gonadotropins and GnRH antagonist, flexible GnRH antagonist protocol and a short GnRH agonist protocol. PATIENTS AND METHODS: Between July 2014 and December 2015 we enrolled 250 poor responders in a previous IVF cycle at least 3 months before...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27821562/oxidative-stress-in-granulosa-lutein-cells-from-in-vitro-fertilization-patients
#8
Julio Ávila, Rebeca González-Fernández, Deborah Rotoli, Jairo Hernández, Angela Palumbo
Ovarian aging is associated with gradual follicular loss by atresia/apoptosis. Increased production of toxic metabolites such as reactive oxygen species (ROS) and reactive nitrogen species as well as external oxidant agents plays an important role in the process of ovarian senescence and in the pathogenesis of ovarian pathologies such as endometriosis and polycystic ovary syndrome (PCOS). This review provides a synthesis of available studies of oxidative stress (OS) in the ovary, focusing on the most recent evidence obtained in mural granulosa-lutein (GL) cells of in vitro fertilization patients...
December 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27821469/removal-of-mouse-ovary-fat-pad-affects-sex-hormones-folliculogenesis-and-fertility
#9
Hong-Hui Wang, Qian Cui, Teng Zhang, Lei Guo, Ming-Zhe Dong, Yi Hou, Zhen-Bo Wang, Wei Shen, Jun-Yu Ma, Qing-Yuan Sun
As a fat storage organ, adipose tissue distributes widely all over the body and is important for energy supply, body temperature maintenance, organ protection, immune regulation and so on. In human, both underweight and overweight women are hard to become pregnant, which suggests that appropriate fat storage can guarantee the female reproductive capacity. In fact, a large mass of adipose tissue distributes around the reproductive system both in the male and female. However, the functions of ovary fat pad (the nearest adipose tissue to ovary) are not known...
November 7, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27817037/effect-of-body-mass-index-on-the-outcomes-of-controlled-ovarian-hyperstimulation-in-chinese-women-with-polycystic-ovary-syndrome-a-multicenter-prospective-observational-study
#10
Yan Sheng, Guangxiu Lu, Jiayin Liu, Xiaoyan Liang, Yanping Ma, Xuehong Zhang, Songying Zhang, Yingpu Sun, Yun Sun, Wenfeng Chen, Wenhui Fang, Zijiang Chen
PURPOSE: The purpose of the present study is to explore the influence of body mass index (BMI) on outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) techniques in Chinese women with polycystic ovary syndrome (PCOS). METHODS: This was a multicenter, prospective, observational study that enrolled 800 subjects with PCOS from nine hospitals in China. Patients were categorized according to BMI categories: underweight, <18.5 kg/m(2); normal, 19-23...
November 5, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27809846/the-participation-of-the-muscarinic-receptors-in-the-preoptic-anterior-hypothalamic-areas-in-the-regulation-of-ovulation-depends-on-the-ovary
#11
Adriana Espinosa-Valdez, Angélica Flores, Isabel Arrieta-Cruz, Mario Cárdenas, Roberto Chavira, Roberto Domínguez, María Esther Cruz
BACKGROUND: Muscarinic receptors (mAChRs) of the preoptic and anterior hypothalamus areas (POA-AHA) regulate ovulation in an asymmetric manner during the estrous cycle. The aims of the present study were to analyze the effects of a temporal blockade of mAChRs on either side of the POA-AHA performed in diestrus-2 rats on ovulation, the levels of estradiol, follicle stimulating hormone (FSH) and luteinizing hormone (LH) and the mechanisms involved in changes in ovulation. METHODS: Cyclic rats on diestrus-2 day were anesthetized and randomly assigned to the following groups: 1) microinjection of 1 μl of saline or atropine solution (62...
November 4, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27809804/prevalence-of-testosterone-deficiency-in-hiv-infected-men-under-antiretroviral-therapy
#12
Ana Rita Gomes, Pedro Souteiro, Carolina Germana Silva, Bernardo Sousa-Pinto, Francisco Almeida, António Sarmento, Davide Carvalho, Paula Freitas
BACKGROUND: The prevalence of hypogonadism in HIV-infected patients is still a matter of debate as there is no standardized consensual diagnostic method. In addition, the etiology and endocrine/metabolic implications of hypogonadism in this population remain controversial. This study aims to determine the prevalence of testosterone deficiency in a single-site hospital and to evaluate its association with potential risk factors, lipodystrophy, metabolic syndrome, and cardiovascular risk...
November 3, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27803898/candidate-gene-expression-in-bos-indicus-ovarian-tissues-prepubertal-and-postpubertal-heifers-in-diestrus
#13
Mayara Morena Del Cambre Amaral Weller, Marina Rufino S Fortes, Laercio R Porto-Neto, Matthew Kelly, Bronwyn Venus, Lisa Kidd, João Paulo Arcelino do Rego, Sophia Edwards, Gry B Boe-Hansen, Emily Piper, Sigrid A Lehnert, Simone Eliza Facioni Guimarães, Stephen Stewart Moore
Growth factors such as bone morphogenetic proteins 6, 7, 15, and two isoforms of transforming growth factor-beta (BMP6, BMP7, BMP15, TGFB1, and TGFB2), and insulin-like growth factor system act as local regulators of ovarian follicular development. To elucidate if these factors as well as others candidate genes, such as estrogen receptor 1 (ESR1), growth differentiation factor 9 (GDF9), follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), bone morphogenetic protein receptor, type 2 (BMPR2), type 1 insulin-like growth factor receptor (IGFR1), and key steroidogenic enzymes cytochrome P450 aromatase and 3-β-hydroxysteroid dehydrogenase (CYP19A1 and HSD3B1) could modulate or influence diestrus on the onset of puberty in Brahman heifers, their ovarian mRNA expression was measured before and after puberty (luteal phase)...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27766729/testicular-sperm-extraction-for-patients-with-spinal-cord-injury-related-anejaculation-a-single-center-experience
#14
Toshiyuki Iwahata, Takeshi Shin, Yukihito Shimomura, Keisuke Suzuki, Tomohiro Kobayashi, Akane Miyata, Yoshitomo Kobori, Shigehiro Soh, Hiroshi Okada
OBJECTIVES: To present a single-center experience with testicular sperm extraction and intracytoplasmic sperm injection for fathering biological children in patients with ejaculatory dysfunction as a result of spinal cord injury. METHODS: Testicular sperm extraction was carried out in 52 male patients with ejaculatory dysfunction as a result of spinal cord injury. We investigated sperm retrieval rates and pregnancy rates from medical records. Data on age, testicular volume, hormonal status (luteinizing hormone, follicle stimulating hormone and testosterone), and time since spinal cord injury were obtained and analyzed to detect potential associations with the presence of spermatogenesis...
December 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27760084/effect-of-gua-sha-therapy-on-perimenopausal-syndrome-a-randomized-controlled-trial
#15
Fang Meng, Pei-Bei Duan, Junya Zhu, Qing-Qing Lou, Zhao-Hui Fang, Hong-Li An, Lan-Ying Liu, Yue Hu, Qian Hu
OBJECTIVE: This study aims to evaluate the effectiveness and safety of Gua sha therapy on perimenopausal symptoms, quality of life, and serum female hormones in participants with perimenopausal syndrome. METHODS: A prospective, randomized, controlled clinical trial was conducted at the First Affiliated Hospital of Nanjing University of Chinese Medicine in China. Eighty women with perimenopausal syndrome were recruited and randomized into an intervention group or a control group...
October 10, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27756786/a-phase-ii-randomized-open-label-study-of-neoadjuvant-degarelix-versus-lhrh-agonist-in-prostate-cancer-patients-prior-to-radical-prostatectomy
#16
Rashid Sayyid, Andrew Evans, Karen Hersey, Ranjena Maloni, Antonio Hurtado-Coll, Girish Kulkarni, Antonio Finelli, Alexandre R Zlotta, Robert Hamilton, Martin Gleave, Neil Fleshner
PURPOSE: Degarelix, a new GnRH receptor antagonist with demonstrated efficacy as first-line treatment in the management of high-risk prostate cancer, possesses some theoretical advantages over LHRH analogues in terms of avoiding "testosterone flare" and lower FSH levels. We set out to determine if pre-operative degarelix influenced surrogates of disease control in a randomized phase II study. EXPERIMENTAL DESIGN: 39 patients were randomly assigned to one of 3 different neo-adjuvant arms: degarelix only, degarelix/bicalutmaide, or LHRH agonist/bicalutamide...
October 18, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27743690/gnrh-agonist-implants-suppress-reproductive-function-and-affects-ovarian-lhr-and-fshr-expression-in-prepubertal-female-cats
#17
N S Mehl, S Srisuwatanasagul, T Swangchan-Uthai, S Sirivaidyapong, M Khalid
Effect of a GnRH-agonist (deslorelin) was studied on reproductive function and ovarian luteinizing hormone receptor (LHR) and follicle stimulating hormone receptor (FSHR) expression in prepubertal female cats that were either implanted with 4.7-mg deslorelin (implanted: n = 6) or not (controls: n = 18) or ovariohysterectomized at prepubertal age (prepubertal OVH: n = 6). Body weights, fecal estradiol, and sexual behavior of implanted and control cats were monitored for 48 weeks followed by collection of ovaries and uteri...
September 9, 2016: Theriogenology
https://www.readbyqxmd.com/read/27737330/age-related-endocrine-patterns-observed-in-polycystic-ovary-syndrome-patients-vs-ovulatory-controls-descriptive-data-from-a-university-based-infertility-center
#18
Batool Hossein Rashidi, Mansoureh Gorginzadeh, Soroush Aalipour, Eric Scott Sills
Objective: To compare serum anti-Müllerian hormone (AMH) and other endocrine parameters between patients diagnosed with polycystic ovary syndrome (PCOS) and age-matched ovulatory women. Materials and methods: AMH, DHEAS, FSH, LH, PRL, TSH and total testosterone (TT) were prospectively measured in oligo-ovulatory PCOS patients (n = 595) and in ovulatory non-PCOS women (n = 157) referred to a tertiary infertility center. Mean BMI was similar across the two study populations and there were no smokers in the sample...
October 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27702735/endemic-fluorosis-in-henan-province-china-er%C3%AE-gene-polymorphisms-and-reproductive-hormones-among-women
#19
Guo-Yu Zhou, Li-Jun Ren, Jia-Xiang Hou, Liu-Xin Cui, Zhong Ding, Xue-Min Cheng, Jing-Yuan Zhu, Rui-Rui Cui, Yue Ba
BACKGROUND AND OBJECTIVES: The aim of this study was to explore the influence of fluoride exposure and ERα gene polymorphisms on reproductive hormone concentrations of women in accordance with endemic fluorosis residence. METHODS AND STUDY DESIGN: A cross sectional study was conducted in Tongxu county, Henan Province, China. A total of 679 women were recruited using cluster sampling and each subject provided fasting blood and an associated urine sample. We measured the concentrations of serum gonadotropin releasing hormone (GnRH), follicle-stimulating hormone, luteinizing hormone, and estradiol and urinary fluoride...
December 2016: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27700136/adiponectin-deficiency-leads-to-female-subfertility-and-ovarian-dysfunctions-in-mice
#20
Lixian Cheng, Hui Shi, Yan Jin, Xiaoxi Li, Jinshun Pan, Yimei Lai, Yan Lin, Ya Jin, Gaurab Roy, Allan Zhao, Fanghong Li
Adipose tissue plays an important role in regulating female fertility, owing to not only its energy stores but also the endocrine actions of secreted adipokines. As one of the adipokines, adiponectin is almost exclusively secreted from the fat, and its circulating concentration is paradoxically reduced in obesity. Although recent studies implied a purported positive role of adiponectin in ovarian functions, definitive in vivo evidence has been sorely lacking. We have consistently observed subfertility in female adiponectin null mice and therefore postulated a protective role of adiponectin in ovarian functions...
December 2016: Endocrinology
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