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diminished ovarian reserve

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https://www.readbyqxmd.com/read/29871793/antim%C3%A3-llerian-hormone-as-a-risk-factor-for-miscarriage-in-naturally-conceived-pregnancies
#1
Brianna M Lyttle Schumacher, Anne Marie Z Jukic, Anne Z Steiner
OBJECTIVE: To determine the association between antimüllerian hormone (AMH), a measure of ovarian reserve, and miscarriage among naturally conceived pregnancies. DESIGN: Prospective cohort study. SETTING: Not applicable. PATIENT(S): Women (n = 533), between 30 and 44 years of age with no known history of infertility, polycystic ovarian syndrome, or endometriosis who conceived naturally. INTERVENTION(S): None...
June 2, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29847457/endometrioma-fertility-and-assisted-reproductive-treatments-connecting-the-dots
#2
Gustavo N Cecchino, Juan A García-Velasco
PURPOSE OF REVIEW: Surgery has traditionally been the primary treatment option for endometriosis-related infertility of any phenotype. However, advances and refinements of assisted reproductive technologies (ART) permit a more conservative approach in many scenarios. This review summarizes the latest findings in the field of reproductive medicine, which have supported a paradigm shift towards more conservative management of ovarian endometrioma. RECENT FINDINGS: The presence of ovarian endometrioma per se is likely to impair ovarian reserve and alter ovarian functional anatomy...
May 29, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29779472/effect-of-body-weight-on-metabolic-hormones-and-fatty-acid-metabolism-in-follicular-fluid-of-women-undergoing-in-vitro-fertilization-a-pilot-study
#3
Laurice Bou Nemer, Haolin Shi, Bruce Richard Carr, Ruth Ann Word, Orhan Bukulmez
INTRODUCTION: Obesity is an epidemic affecting more than one-third of adults in the United States. Obese women experience decreased fertility, explained in part by oocyte quality. Since follicular fluid (FF) provides an important microenvironment for oocyte growth, we sought to evaluate the effect of increased body weight on FF levels of 11 metabolic hormones and fatty acid metabolism. METHODS: The FF was collected from 25 women (10 normal weight, 10 overweight, and 5 obese) with diminished ovarian reserve undergoing in vitro fertilization (IVF) following a minimal stimulation protocol...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29724534/low-anti-m%C3%A3-llerian-hormone-concentration-is-associated-with-increased-risk-of-embryonic-aneuploidy-in-women-of-advanced-age
#4
Xiao Jiang, Junhao Yan, Yan Sheng, Mei Sun, Linlin Cui, Zi-Jiang Chen
RESEARCH QUESTION: Does an association exist between serum anti-Müllerian hormone (AMH) level, the marker of biological ovarian age, and embryonic aneuploidy risk in recurrent spontaneous miscarriage (RSM) patients of reproductive age? DESIGN: This retrospective study included a total of 422 IVF cycles of 394 unexplained RSM patients undergoing preimplantation genetic testing for aneuploidy (PGT-A), enrolled from January 2014 to December 2016. Subjects were divided into three groups according to the 25th (1...
April 13, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29697414/the-dilemma-of-aneuploidy-screening-on-low-responders
#5
Scott J Morin, Daniel J Kaser, Jason M Franasiak
PURPOSE OF REVIEW: Preimplantation genetic testing for aneuploidy (PGT-A) has been demonstrated to improve implantation and pregnancy rates and decrease miscarriage rates over standard morphology-based embryo selection. However, there are limited data on its efficacy in patients with diminished ovarian reserve or a poor response to stimulation who may have fewer embryos to select amongst. RECENT FINDINGS: Early findings demonstrate that PGT-A reduces the miscarriage rate and decreases the time to delivery in poor responders...
June 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29695822/dacarbazine-depletes-the-ovarian-reserve-in-mice-and-depletion-is-enhanced-with-age
#6
Amy L Winship, Monika Bakai, Urooza Sarma, Seng H Liew, Karla J Hutt
Dacarbazine is commonly administered for the treatment of cancers prevalent in reproductive age females. However, investigations of off-target effects of dacarbazine on the ovary are limited. We assessed the impact of dacarbazine on the ovarian reserve of primordial follicles, essential for fertility. Eight week and 6 month old C57BL/6 J mice were administered with dacarbazine or saline on day (d)0 and d7, then sacrificed after 12 hours (h), or 14d (n = 4-5/group). Follicle numbers, follicle density, serum AMH and corpora lutea were quantified and estrous cyclicity monitored...
April 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29695208/comparison-of-modified-agonist-mild-stimulation-and-antagonist-protocols-for-in-vitro-fertilization-in-patients-with-diminished-ovarian-reserve
#7
Rong Yu, Hao Jin, Xuefeng Huang, Jinju Lin, Peiyu Wang
Objective To compare the efficacy of three protocols for ovarian stimulation in patients with diminished ovarian reserve during in vitro fertilization (IVF) treatment. Methods This prospective randomized study enrolled patients with diminished ovarian reserve who underwent cycles of IVF or intracytoplasmic sperm injection. The patients were randomly divided into three groups: a modified gonadotrophin releasing hormone (GnRH) agonist protocol (group A); (ii) a mild stimulation protocol (group B); or (iii) an antagonist protocol (group C)...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29688494/discordance-between-serum-anti-m%C3%A3-llerian-hormone-concentrations-and-antral-follicle-counts-not-only-technical-issues
#8
M Š Alebic, N Stojanovic, D Dewailly
STUDY QUESTION: Do patient-specific features contribute to the differences between measured serum anti-Müllerian hormone (AMH) concentrations and AMH values expected from the corresponding antral follicle count (AFC)? SUMMARY ANSWER: Patient-specific features contribute to the differences between measured AMH values and AMH values expected from the corresponding AFC (AMHp), potentially through their effect on follicular AMH production. WHAT IS KNOWN ALREADY: Both patient counselling and patient management could be hampered by finding of disagreement between AFC and AMH if both are used for the prediction of ovarian response...
June 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29673665/diminished-ovarian-reserve-in-patients-with-psoriasis
#9
Burcu Tuğrul Ayanoğlu, Elif Didem Özdemir, Onur Türkoğlu, Aslıhan Alhan
OBJECTIVE: Psoriasis is a multi-systemic chronic inflammatory skin disease. Previous data suggests that women with some chronic inflammatory diseases have diminished ovarian reserve. This study explores ovarian reserve in patients with psoriasis. MATERIALS AND METHODS: We prospectively analyzed 14 female patients with psoriasis and 35 healthy age and body mass index matched controls. An interview explored demographic characteristics, obstetrical history and menstrual characteristics...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29652213/ovarian-reserve-in-young-juvenile-idiopathic-arthritis-patients
#10
Gabriela R V Ferreira, Renato B Tomioka, Nadia E Aikawa, Elaine P Leon, Gustavo A R Maciel, Paulo C Serafini, Edmund C Baracat, Claudia Goldenstein-Schainberg, Rosa M R Pereira, Eloisa Bonfá, Clovis A Silva
OBJECTIVES: Juvenile idiopathic arthritis (JIA) occurs during reproductive age, however, there are no systematic data regarding ovarian function in this disease. METHODS: Twenty-eight post-pubertal JIA patients and age-matched 28 healthy controls were studied. Complete ovarian function was assessed during the early follicular phase of the menstrual cycle including anti-Müllerian hormone (AMH), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) by ovarian ultrasound, and anti-corpus lutheum antibodies (anti-CoL)...
May 4, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29611308/factors-impacting-couples-decision-making-between-vasectomy-reversal-versus-sperm-retrieval-in-vitro-fertilization-intracytoplasmic-sperm-injection
#11
P K Kavoussi, K M Kavoussi, K C Odenwald, S K Kavoussi
The purpose of this study was to identify factors which impact a couples' decision-making between the options of vasectomy reversal vs. sperm retrieval/in vitro fertilization/intracytoplasmic sperm injection when counseled both by a reproductive urologist and a reproductive endocrinologist. A retrospective chart review was performed of couples who wish to achieve a pregnancy with a male partner with a history of prior vasectomy, in a couples' private fertility center. Of patients presenting for fertility options with a history of vasectomy, 175 couples elected to be counseled by both a reproductive urologist and a reproductive endocrinologist on the options between vasectomy reversal and sperm retrieval/in vitro fertilization/intracytoplasmic sperm injection, with 78...
April 2, 2018: Andrology
https://www.readbyqxmd.com/read/29590425/mir-106a-increases-granulosa-cell-viability-and-is-down-regulated-in-women-with-diminished-ovarian-reserve
#12
Liming Hong, Sha Peng, Ying Li, Ying Fang, Qin Wang, Christian Klausen, Chenghong Yin, Shuyu Wang, Peter C K Leung, Xiaokui Yang
Context: Women with diminished ovarian reserve (DOR) suffer from reduced fertility, cardiovascular events and osteoporosis. Though differential microRNA (miRNA) expression has been described in several ovarian disorders, little is known about the role of miRNAs in the pathogenesis of DOR. Objective: Identify differentially expressed miRNAs in DOR and explore the role of miR-106a in human granulosa cell proliferation. Design: MiRNA microarray (n=3) and RT-qPCR (n=30) were used to examine miRNA expression in serum and granulosa cells from normal cycling and DOR women...
March 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29564948/the-effects-of-sclerotherapy-with-5-trichloroacetic-acid-on-the-cyst-diameter-and-ovarian-tissue-in-the-rat-ovarian-cyst-model
#13
Gökhan Artaş, Şehmus Pala, Tuncay Kuloğlu, Remzi Atilgan, Şeyda Yavuzkir, Alparslan Akyol
The aim of this study was to compare the effects of only aspiration with aspiration and 5% trichloroacetic acid (TCA) application on ovarian cyst size and ovarian reserve. The ovarian cysts of 14 rats that were divided into two groups randomly were investigated after total salpingectomy procedure. G1 was the group of saline application after cyst aspiration, while in G2, after aspiration 5% TCA at half amount of aspiration volume was injected into the cyst and re-aspirated after five minutes. The abdomens of the rats were closed and re-explored after 1 month...
March 22, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29564925/luteal-phase-ovarian-stimulation-increases-the-number-of-mature-oocytes-in-older-women-with-severe-diminished-ovarian-reserve
#14
Justin Rashtian, John Zhang
In older women with severe diminished ovarian response (DOR), in vitro fertilization (IVF) treatment is much less successful due to the low number of mature oocytes collected. The objective of this study was to assess whether follicular-phase stimulation (FPS) and luteal-phase stimulation (LPS) in the same menstrual cycle (double ovarian stimulation) in older women with severe DOR will produce a higher number of oocytes compared to FPS alone. Women with DOR (n = 69; mean age = 42.4) who underwent double ovarian stimulation for IVF were included...
June 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29546326/a-rationale-for-biopsying-embryos-reaching-the-morula-stage-on-day-6-in-women-undergoing-preimplantation-genetic-testing-for-aneuploidy
#15
M Irani, N Zaninovic, C Canon, C O'Neill, V Gunnala, Q Zhan, G Palermo, D Reichman, Z Rosenwaks
STUDY QUESTION: Is there a benefit to assessing ploidy in delayed embryos reaching the morula stage on Day 6 of development? SUMMARY ANSWER: Day-6 morulae should be considered for biopsy in women <40 years old undergoing preimplantation genetic testing for aneuploidy (PGT-A) because they are associated with acceptable, albeit reduced, euploidy and implantation rates (IRs). WHAT IS KNOWN ALREADY: Embryo development and morphology have been shown to correlate with aneuploidy and pregnancy rates...
May 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29526798/effects-of-dehydroepiandrosterone-on-the-ovarian-reserve-and-pregnancy-outcomes-in-perimenopausal-rats-dhea-and-fertility-in-perimenopausal-rats
#16
Yomna I Mahmoud, Asmaa A Mahmoud, Faten S Abo-Zeid, Nagui H Fares
BACKGROUND: Dehydroepiandrosterone (DHEA) is a weak androgen and a crucial precursor of sex steroids. Exogenous supplementation of DHEA is now being commonly used to augment ovarian stimulation in women with diminished ovarian reserve. However, the effects of DHEA are controversial. AIMS: This study verifies the effects of pharmacologic doses of DHEA on the ovarian reserve variables, follicular development, reproductive function, and pregnancy outcomes of perimenopausal rats...
April 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29486615/first-data-on-in-vitro-fertilization-and-blastocyst-formation-after-intraovarian-injection-of-calcium-gluconate-activated-autologous-platelet-rich-plasma
#17
E Scott Sills, Natalie S Rickers, Xiang Li, Gianpiero D Palermo
Platelets modulate clinically relevant yet incompletely understood tissue regeneration processes, and platelet rich plasma (PRP) has been previously used with some success in various non-reproductive medical contexts. Here, we extended PRP application to ovarian tissue with a view to document impact on ovarian reserve among women attending for infertility treatment. PRP was freshly isolated from patients (n= 4) with diminished ovarian reserve as determined by at least one prior IVF cycle canceled for poor follicular recruitment response or estimated by serum AMH and/or FSH, no menses for ≥1 year...
February 28, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29476810/impact-of-ultrasound-guided-transvaginal-ovarian-needle-drilling-versus-laparoscopic-ovarian-drilling-on-ovarian-reserve-and-pregnancy-rate-in-polycystic-ovary-syndrome-a-randomized-clinical-trial
#18
Mohamed Kandil, Mohamed Rezk, Alaa Al-Halaby, Mohamed Emarh, Ibrahim Saif El-Nasr
STUDY OBJECTIVE: To compare the impact of ultrasound-guided transvaginal ovarian needle drilling (TND) versus laparoscopic ovarian drilling (LOD) on ovarian reserve and pregnancy rate in patients with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS). DESIGN: A randomized clinical trial (Canadian Task Force classification I). SETTING: A university hospital. PATIENTS: Of 644 patients who presented at an infertility clinic, 246 with CC-resistant PCOS were randomized for treatment...
February 21, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29471860/urinary-phthalate-metabolites-in-relation-to-serum-anti-m%C3%A3-llerian-hormone-and-inhibin-b-levels-among-women-from-a-fertility-center-a-retrospective-analysis
#19
Yao-Yao Du, Na Guo, Yi-Xin Wang, Xiang Hua, Tao-Ran Deng, Xue-Mei Teng, Yang-Cheng Yao, Yu-Feng Li
BACKGROUND: Phthalates, a class of endocrine disruptors, have been demonstrated to accelerate loss of ovarian follicle pool via disrupting folliculogenesis, and lead to diminished ovarian reserve. However, human data are limited. Here, we aimed to examine whether urinary phthalate metabolites are correlated with markers of ovarian reserve among women attending a fertility clinic. METHODS: We measured eight phthalate metabolites in urine samples collected from 415 women seeking infertility treatment at the Reproductive Medicine Center of Tongji Hospital, Wuhan, China...
February 23, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29428311/impact-of-cancer-treatment-on-risk-of-infertility-and-diminished-ovarian-reserve-in-women-with-polycystic-ovary-syndrome
#20
Lisa M Shandley, Amy Fothergill, Jessica B Spencer, Ann C Mertens, Hanh N Cottrell, Penelope P Howards
OBJECTIVE: To compare markers of fertility and ovarian reserve between cancer survivors and cancer-free women with and without polycystic ovary syndrome (PCOS). DESIGN: Furthering Understanding of Cancer, Health, and Survivorship in Adult (FUCHSIA) Women's Study-a population-based cohort study. SETTING: Not applicable. PATIENT(S): Female cancer survivors (n = 1,090) aged 22-45 years, diagnosed between ages 20 and 35 years, and at least 2 years after diagnosis; 369 participated in a clinic visit...
March 2018: Fertility and Sterility
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