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diminished ovarian reserve

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https://www.readbyqxmd.com/read/28173995/gnrh-antagonist-and-letrozole-co-treatment-in-diminished-ovarian-reserve-patients-a-proof-of-concept-study
#1
Safak Olgan, Peter Humaidan
The current study aimed to investigate the effects of luteal gonadotropin-releasing hormone (GnRH) antagonist pretreatment on the outcomes of diminished ovarian reserve (DOR) patients who were treated using a FSH/letrozole/GnRH antagonist (FLA) protocol. Thus, patients who had luteal GnRH antagonist pretreatment (AFLA) prior to stimulation were compared to patients who had the FLA protocol, only. An electronic database was used to identify patients and stimulation characteristics. Women who had a total antral follicle count (AFC) of <7 were included in the analysis...
February 4, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28122315/intrauterine-insemination-no-more-mr-n-i-c-e-guy
#2
Minna E Geisler, Mark Ledwidge, Margaret Bermingham, Mary McAuliffe, Moya B McMenamin, John J Waterstone
OBJECTIVE: To determine the per cycle chance of a live birth and to identify factors that may support a more individualised application of IUI in view of National Institute for Health and Care Excellence (NICE) updated guideline on fertility 2013. STUDY DESIGN: A retrospective, cohort study of 851 couples (1688 cycles) with unexplained, mild endometriosis, one patent Fallopian tube (with ovulation occurring in the corresponding ovary), mild male factor or ovulatory dysfunction, who initiated their first cycle of IUI/COH during the study period 2009-2013 and completed up to 3 cycles...
January 18, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28104240/serum-and-follicular-fluid-monocyte-chemotactic-protein-1-levels-are-elevated-in-obese-women-and-are-associated-with-poorer-clinical-pregnancy-rate-after-in%C3%A2-vitro-fertilization-a%C3%A2-pilot-study
#3
Erkan Buyuk, Obehi A Asemota, Zaher Merhi, Maureen J Charron, Dara S Berger, Athena Zapantis, Sangita K Jindal
OBJECTIVE: To determine whether monocyte chemotactic protein-1 (MCP-1), a proinflammatory chemokine important in ovulation, is abnormally elevated in obese women undergoing IVF and whether serum and follicular fluid (FF) levels of MCP-1 are associated with IVF outcome. DESIGN: Prospective pilot study. SETTING: Academic center. PATIENT(S): Women undergoing IVF. INTERVENTION(S): Serum and FF were collected from women undergoing IVF...
January 16, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28081480/does-the-addition-of-salpingectomy-or-fimbriectomy-to-hysterectomy-in-premenopausal-patients-compromise-ovarian-reserve-a-prospective-study
#4
Y Naaman, Y Hazan, M Gillor, G Marciano, R Bardenstein, Z Shoham, A Ben-Arie
OBJECTIVE: To evaluate changes in ovarian reserve in patients following hysterectomy, with or without bilateral salpingectomy or fimbriectomy. STUDY DESIGN: Open-label, prospective cohort trial of patients undergoing hysterectomy for benign uterine indications. Levels of follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), and ultrasonic measures of peak systolic flow velocity/diastolic velocity (S/D) ratio and resistance index (RI) in the ovarian artery were taken from patients before and 6 weeks after hysterectomy, hysterectomy+salpingectomy or hysterectomy+fimbriectomy...
December 27, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28010150/repeated-doses-of-gnrh-antagonist-at-midcycle-in-artificial-frozen-embryo-transfer-cycles-may-not-affect-pregnancy-outcomes
#5
Katherine L Palmerola, Jennifer Y Hsu, Lisa C Grossman, Mark V Sauer, Roger A Lobo
No significant differences in outcomes have been found between protocols of endometrial preparation for frozen embryo transfer (FET), though gonadotropin releasing hormone (GnRH) antagonists may have detrimental effects on the endometrium. We conducted a retrospective cohort noninferiority study at a single academic center of women receiving multiple doses of mid-cycle GnRH antagonist (GAnt) to those receiving GnRH agonist (GAg) to determine if there are detrimental effects of GnRH antagonists. 1047 FET cycles were identified, detailed data was available in 840 cycles: 610 GAg and 230 GAnt cycles...
December 23, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28001021/outcomes-of-first-ivf-icsi-in-young-women-with-diminished-ovarian-reserve
#6
Jonathan Cohen, Leonisse Mounsambote, Perrine Prier, Emmanuelle Mathieu D'Argent, Lise Selleret, Nathalie Chabbert-Buffet, Vanina Delarouziere, Rachel Levy, Emile Darai, Jean M Antoine
BACKGROUND: There is no consensual definition of diminished ovarian reserve and the best therapeutic strategy has not yet been demonstrated. METHODS: We performed a retrospective study to evaluate outcomes following a first IVF/ICSI cycle in young women with diminished ovarian reserve. Women with tubal factor, endometriosis or previous stimulation cycle were excluded. We defined diminished ovarian reserve as women ≤38 years with an AMH ≤1.1 ng/mL or antral follicular count ≤7...
December 21, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27995424/fragile-x-premutation-in-women-recognizing-the-health-challenges-beyond-primary-ovarian-insufficiency
#7
REVIEW
Luis R Hoyos, Mili Thakur
Fragile X premutation carriers have 55-200 CGG repeats in the 5' untranslated region of the FMR1 gene. Women with this premutation face many physical and emotional challenges in their life. Approximately 20% of these women will develop fragile X-associated primary ovarian insufficiency (FXPOI). In addition, they suffer from increased rates of menstrual dysfunction, diminished ovarian reserve, reduction in age of menopause, infertility, dizygotic twinning, and risk of having an offspring with a premutation or full mutation...
December 19, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27927044/dehydroepiandrosterone-dhea-supplementation-and-ivf-outcome-in-poor-responders
#8
Olga Triantafyllidou, George Sigalos, Nikos Vlahos
Ovarian stimulation of poor ovarian responders still remains a challenging issue. The incidence of poor responders among infertile women is reported in 9-24% IVF cycles and is associated with very low clinical pregnancy rates. Different treatments have been reported in the literature in an attempt to identify the best stimulation protocol for those patients. Administration of dehydroepiandrosterone acetate (DHEA) was suggested as a promising treatment. It is well known that androgens can influence ovarian follicular growth, augment steroidogenesis, promote follicular recruitment and increase the number of primary and pre-antral follicles...
December 7, 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27906603/utility-of-ovarian-reserve-screening-with-anti-m%C3%A3-llerian-hormone-for-reproductive-age-women-deferring-pregnancy
#9
Lisa C Grossman, Lauren Zakarin Safier, Melissa D Kline, Cariann W Chan, Rogerio A Lobo, Mark V Sauer, Nataki C Douglas
BACKGROUND: Ovarian reserve (OR) testing with serum anti-Müllerian hormone (AMH) can provide information about a woman's fertility potential. The aim of this study was to assess interest and knowledge about OR testing and investigate the utility of measuring AMH in women of reproductive age deferring pregnancy. METHODS: Women ages 27-37 years currently delaying childbearing were invited to take a survey regarding attitudes and knowledge about OR testing before and after an AMH measurement with explanation of their results...
December 1, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27890715/effects-of-atrazine-on-ovarian-growth-in-the-estuarine-crab-neohelice-granulata
#10
G R Silveyra, I S Canosa, E M Rodríguez, D A Medesani
Atrazine, a herbicide that is intensively used in Argentina, was assayed to evaluate the alteration of reproduction in a wild species of crustaceans. Adult females of the estuarine crab Neohelice granulata were exposed to formulated atrazine during the 3-month pre-reproductive period. Three atrazine concentrations (0.03, 0.3 and 3mg/L) were assayed, together with a water dilution control. At the end of the exposure period, several variables concerning the energetic status of animals were measured, such as weight gain, glycemia, and energy reserves in both muscle and hepatopancreas...
February 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/27876427/fmr1-premutation-not-only-important-in-premature-ovarian-failure-but-also-in-diminished-ovarian-reserve
#11
Ali Eslami, Kamelia Farahmand, Mehdi Totonchi, Tahereh Madani, Ummulbanin Asadpour, Shabnam Zari Moradi, Hamid Gourabi, Anahita Mohseni-Meybodi
It is recognized that FMR1 premutation expansions are associated with premature ovarian failure (POF), but their role in diminished ovarian reserve (DOR) is not clearly established. Moreover, the impact of smaller repeats at the boundary of premutation and normal is less clear. Therefore, we have compared the frequency of these intermediate (45-54 repeats) and premutation (>55) sized FMR1 CGG repeats among a patients group including 188 DOR and 173 POF women and 200 controls. FSH and LH concentrations were also compared between intermediate and premutation ranges in patients...
November 23, 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27852688/the-role-of-intracytoplasmic-sperm-injection-in-non-male-factor-infertility-in-advanced-maternal-age
#12
Samer Tannus, Weon-Young Son, Ashley Gilman, Grace Younes, Tal Shavit, Michael-Haim Dahan
STUDY QUESTION: Does ICSI improve reproductive outcomes compared with conventional IVF when used for non-male factor infertility in women aged 40 years and over? SUMMARY ANSWER: There is no advantage of ICSI over conventional IVF in women aged 40 years and over when used for non-male factor infertility. WHAT IS KNOWN ALREADY: The use of ICSI has increased dramatically in recent years and is being applied for indications other than male factor infertility...
January 2017: Human Reproduction
https://www.readbyqxmd.com/read/27816231/distribution-of-the-fmr1-gene-in-females-by-race-ethnicity-women-with-diminished-ovarian-reserve-versus-women-with-normal-fertility-swan-study
#13
Lisa M Pastore, Steven L Young, Ani Manichaikul, Valerie L Baker, Xin Q Wang, Joel S Finkelstein
OBJECTIVE: To study whether reported, but inconsistent, associations between the FMR1 CGG repeat lengths in the intermediate, high normal, or low normal range differentiate women diagnosed with diminished ovarian reserve (DOR) from population controls and whether associations vary by race/ethnic group. DESIGN: Case-control study. SETTING: Academic and private fertility clinics. PATIENT(S): DOR cases (n = 129; 95 Whites, 22 Asian, 12 other) from five U...
January 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/27780981/longitudinal-observation-of-serum-anti-m%C3%A3-llerian-hormone-in-three-girls-after-cancer-treatment
#14
Yoko Miyoshi, Kie Yasuda, Makiko Tachibana, Hisao Yoshida, Emiko Miyashita, Takako Miyamura, Yoshiko Hashii, Kae Hashimoto, Tadashi Kimura, Keiichi Ozono
Gonadal dysfunction and infertility are major endocrinological late effects among childhood cancer survivors. Chemotherapy and radiation have gonadotoxic effects and diminish the ovarian reserve. The serum concentration of anti-Müllerian hormone (AMH) is a useful marker of ovarian reserve in survivors. We conducted a longitudinal study to investigate the variations of AMH in evaluating the acute and chronic effects of cancer therapy on the ovary. Three young female patients with different hematological diseases were registered, and their medical records were reviewed...
October 2016: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/27769207/neonatal-outcomes-in-pregnancies-resulting-from-oocyte-donation-a-cohort-study-in-sweden
#15
Evangelia Elenis, Gunilla Sydsjö, Alkistis Skalkidou, Claudia Lampic, Agneta Skoog Svanberg
BACKGROUND: Pregnancies resulting through oocyte donation have been associated with increased risk for adverse outcomes for the mother, such as gestational hypertensive disorders. However, little is known about possible neonatal complications of such pregnancies. The purpose of this study was to evaluate the neonatal health outcomes among singleton pregnancies in a population of relatively young and healthy oocyte recipients in Sweden, taking into account the medical indication leading to treatment...
October 21, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27722934/ovarian-tissue-cryopreservation-and-transplantation-scientific-implications
#16
REVIEW
Sherman Silber
After fresh or frozen ovary transplantation, FSH levels return to normal, and menstrual cycles resume by 150 days, coincident with anti-Müllerian hormone rising to higher than normal levels. AMH then returns to well below normal levels by 240 days, remaining as such for many years with nonetheless normal ovulation and fertility. To date, 20 babies have been born in our program from 11 fresh and 13 cryopreserved ovary transplant recipients with a live baby rate of over 70 % (11 babies from fresh and 9 from frozen)...
December 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27702318/in-vitro-activation-a-dip-into-the-primordial-follicle-pool
#17
Ophelia Yin, Kamaria Cayton, James H Segars
CONTEXT: A current limitation of assisted reproduction is the number of available female gametes. This Commentary discusses in vitro activation (IVA), a technique that activates dormant ovarian follicles so that these follicles can become mature oocytes for fertilization. There is considerable evidence that mechanical signaling plays an important role in oocyte maturation and survival; manipulation of the mechanical environment is a key component of the IVA process. IVA acts on existing follicles and does not promote neo-oogenesis, which likely contributes little to the primordial follicle pool in the adult...
October 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27689809/age-related-normogram-for-antral-follicle-count-in-general-population-and-comparison-with-previous-studies
#18
Gurkan Bozdag, Pinar Calis, Dila Zengin, Atakan Tanacan, Sevilay Karahan
OBJECTIVE: To construct antral follicle count (AFC) nomogram of general population for every age and to compare our data with previous studies to assess whether available AFC nomograms present any geographical inconsistency. STUDY DESIGN: A prospective cross-sectional study was conducted to document AFC nomogram among women in 20-50 years with regular menstrual bleeding. Patients admitted with hirsutism, menstrual irregularity, diagnosis of current/history of endometrioma and hormonal drug use within the last 6 months were excluded...
November 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27473349/caution-counseling-patients-with-diminished-ovarian-reserve-and-recurrent-pregnancy-loss-about-in%C3%A2-vitro-fertilization-with-preimplantation-genetic-screening
#19
Ruth B Lathi, Jonathan D Kort
No abstract text is available yet for this article.
October 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27462770/abo-blood-type-is-associated-with-ovarian-reserve-in-chinese-women-with-subfertility
#20
Liangshan Mu, Wumin Jin, Haiyan Yang, Xia Chen, Jiexue Pan, Jia Lin, Peiyu Wang, Xuefeng Huang
Ovarian reserve reflects both the quantity and quality of oocytes available for procreation, and is affected by many known and unknown factors. ABO blood type is related to a number of infertility processes, but it is unclear whether and how ABO blood type affects ovarian reserve. Here, we explored the relationship between ABO blood type and ovarian reserve in Chinese women with subfertility. Day-3 serum follicle-stimulating hormone (FSH) levels and blood type were examined in 14,875 women who underwent IVF or ICSI treatment...
August 9, 2016: Oncotarget
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