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https://www.readbyqxmd.com/read/29785842/circular-rna-0068669-as-a-new-biomarker-for-hepatocellular-carcinoma-metastasis
#1
Ting Yao, Qingqing Chen, Zhouwei Shao, Zhihua Song, Liyun Fu, Bingxiu Xiao
BACKGROUND: Circular RNAs (circRNAs) play important roles in disease occurrence. However, the roles of circRNAs in the diagnosis of hepatocellular carcinoma (HCC) are largely unknown. The aim of this study is to investigate the clinical diagnostic values of hsa_circ_0068669 (Alias: hsa_circ_103561), one of the representative HCC-associated circRNAs. METHODS: Hsa_circ_0068669 expression levels in HCC tissues, HCC cell lines, and chronic hepatitis tissues were detected by real-time quantitative reverse transcription-polymerase chain reaction...
May 21, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29784667/pattern-specific-transcriptomics-identifies-asgr2-as-a-predictor-of-hematogenous-recurrence-of-gastric-cancer
#2
Haruyoshi Tanaka, Mitsuro Kanda, Takashi Miwa, Chie Tanaka, Daisuke Kobayashi, Shinichi Umeda, Masahiro Shibata, Masaya Suenaga, Norifumi Hattori, Masamichi Hayashi, Naoki Iwata, Suguru Yamada, Goro Nakayama, Michitaka Fujiwara, Yasuhiro Kodera
Hematogenous recurrence is a challenging clinical finding that often leads to fatalities of patients with gastric cancer. Therefore, the identification of specific biomarkers and potential therapeutic target molecules for hematogenous recurrence is required to improve the outcomes of these patients. Here, transcriptome and bioinformatics analyses were conducted to uncover candidate molecules differentially expressed in patients with hematogenous recurrence of gastric cancer. One potential candidate identified was asialoglycoprotein receptor 2 (ASGR2) and small interfering RNA (siRNA) experiments were conducted to determine the effect of manipulating ASGR2 expression has on cell phenotypes...
May 21, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29779312/-the-safety-and-effect-of-transhepatic-hilar-approach-for-the-treatment-of-bismuth-type-%C3%A2-and-%C3%A2-hilar-cholangiocarcinoma
#3
M He, H L Wang, J Y Yan, S W Xu, W Chen, J Wang
Objective: To compare the efficiency between the transhepatic hilar approach and conventional approach for the surgical treatment of Bismuth type Ⅲ and Ⅳ hilar cholangiocarcinoma. Methods: There were 42 consecutive patients with hilar cholangiocarcinoma of Bismuth type Ⅲ and Ⅳ who underwent surgical treatment at Department of Biliary-Pancreatic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University from January 2008 to December 2013.The transhepatic hilar approach was used in 19 patients and conventional approach was performed in 23 patients...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29776350/increased-systemic-zonula-occludens-1-associated-with-inflammation-and-independent-biomarker-in-patients-with-hepatocellular-carcinoma
#4
Amit Kumar Ram, Biju Pottakat, Balasubramaniyan Vairappan
BACKGROUND: Hepatocellular carcinoma (HCC) is a frequent type of primary liver cancer, and its prevalence is increasing worldwide. Indeed, the underlying molecular mechanism is not well understood. Previous studies have shown evidence that tight junction (TJ) components were correlated with carcinogenesis and tumor development. Our aims were to determine the serum levels of tight junction protein Zonula Occludens (ZO)-1 and an inflammatory marker such as high-sensitive C-reactive protein (hs-CRP) in HCC patients compared to healthy volunteers and also to identify the association between ZO-1 and inflammation in HCC...
May 18, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29772618/-a-case-of-metastasis-of-cholangiocarcinoma-to-the-bladder
#5
Akiou Okumura, Akihiro Morii, Kiyoshi Takagawa, Hiroshi Kitamura
The patient was an 88-year-old male. He was referred to the Department of Internal Medicine because of total body itching and jaundice in July 2011. The serum bilirubin level was elevated, and the serum CA19-9 level was also elevated to 266. 6 U/ml. Computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP) revealed a solid tumor between the hepatic hilus and common bile duct, and choler cytodiagnosis was class V ; adenocarcinoma. The patient was diagnosed with hilar cholangiocarcinoma and received conservative treatment with endoscopic nasobiliary drainage (ENBD) due to his advanced age...
April 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29766659/prognosis-of-patients-with-hepatocellular-carcinoma-treated-with-sorafenib-a-comparison-of-five-models-in-a-large-canadian-database
#6
Haider H Samawi, Hao-Wen Sim, Kelvin K Chan, Mohammad A Alghamdi, Richard M Lee-Ying, Jennifer J Knox, Parneet Gill, Adriana Romagnino, Eugene Batuyong, Yoo-Joung Ko, Janine M Davies, Howard J Lim, Winson Y Cheung, Vincent C Tam
Several systems (tumor-node-metastasis [TNM], Barcelona Clinic Liver Cancer [BCLC], Okuda, Cancer of the Liver Italian Program [CLIP], and albumin-bilirubin grade [ALBI]) were developed to estimate the prognosis of patients with hepatocellular carcinoma (HCC) mostly prior to the prevalent use of sorafenib. We aimed to compare the prognostic and discriminatory power of these models in predicting survival for HCC patients treated with sorafenib and to identify independent prognostic factors for survival in this population...
May 15, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29766649/lysyl-oxidase-a-colorectal-cancer-biomarker-of-lung-and-hepatic-metastasis
#7
Yun Liu, Guanghui Wang, Zhonglin Liang, Zubing Mei, Tingyu Wu, Ang Cui, Chenying Liu, Long Cui
BACKGROUND: Colorectal cancer (CRC) is a common and lethal disease in which distant metastasis remains the primary cause of death. Paradoxical roles of LOX have been reported in CRC, and the intracellular function of LOX has also recently been determined. Correlations of LOX expression and its intracellular localization with clinicopathological features in CRC patients remain largely unknown. The aim of the present study was to explore the potential roles of LOX in CRC. METHODS: LOX messenger RNA expression was assayed by quantitative PCR in eight paired normal mucosa and tumor tissues...
May 15, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29765250/genetic-variants-in-the-exon-region-of-versican-predict-survival-of-patients-with-resected-early-stage-hepatitis-b-virus-associated-hepatocellular-carcinoma
#8
Xiaoguang Liu, Chuangye Han, Xiwen Liao, Long Yu, Guangzhi Zhu, Hao Su, Wei Qin, Sicong Lu, Xinping Ye, Tao Peng
Background: The upregulated expression of versican (VCAN) promotes the proliferation, invasion, and metastasis of various types of human cancer cells, including hepatocellular carcinoma (HCC) cells. Patients and methods: In this study, genetic variants in the exon region of VCAN were genotyped by DNA sequencing. Prognostic values of VCAN exon single nucleotide polymorphisms (SNPs) were assessed by Kaplan-Meier with the log-rank test, and uni- and multivariate Cox proportional hazard regression model...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29760793/hepatitis-b-virus-infection-predicts-better-survival-in-patients-with-colorectal-liver-only-metastases-undergoing-liver-resection
#9
Yujie Zhao, Junzhong Lin, Jianhong Peng, Yuxiang Deng, Ruixia Zhao, Qiaoqi Sui, Zhenhai Lu, Desen Wan, Zhizhong Pan
Objective: Hepatitis B virus (HBV) infection has been shown to decrease the risk of liver metastasis in patients with non-metastatic colorectal cancer (CRC). However, the prognostic value of HBV infection in long-term survival of patients with colorectal liver-only metastases (CRLM) after liver resection has not yet been evaluated. This study aims to explore the association between HBV infection and survival in CRLM patients. Methods: A total of 289 CRLM patients undergoing liver resection were recruited at our center from September 1999 to August 2015...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29760319/hepatic-eosinophilic-abscess-associated-with-sigmoid-colon-cancer
#10
Yasuyuki Shigematsu, Hiroaki Kanda, Toshiya Nagasaki, Takeaki Ishizawa, Yosuke Inoue, Shunji Takahashi
The clinical course of hepatic eosinophilic abscess (HEA) induced by malignant tumors is not well-known; however, it is considered to be a benign hepatic lesion. HEA is difficult to diagnose by imaging alone and a pathological examination is generally needed, particularly in patients with malignant tumors, because the radiological findings can be similar to those of metastasis. We report a case of multiple HEAs with eosinophilia and sigmoid colon cancer that was difficult to diagnose without a pathological examination...
2018: Internal Medicine
https://www.readbyqxmd.com/read/29757146/imaging-of-pathology-involving-the-space-around-the-hepatic-veins-perivenous-pattern
#11
Ali Devrim Karaosmanoğlu, Mehmet Ruhi Onur, Mustafa Nasuh Özmen, Deniz Akata, Muşturay Karçaaltıncaba
We aimed to illustrate diseases involving the potential space around the hepatic veins. Perivenous halo sign can be seen in patients with congestive heart failure or fluid overload. Perivenous involvement can be observed in patients with alcoholic fatty liver disease, which can be focal or diffuse. Metastasis and primary liver tumor spread can also involve this space most likely due to involvement of lymphatics around hepatic veins.
March 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29754940/radioguided-hepatic-resection-with-18-f-dopa-in-a-patient-with-metastatic-medullary-thyroid-carcinoma
#12
J López-Gómez, S Medina-Ornelas, M A Salazar-Álvarez, M Álvarez-Bojórquez, N Zaragoza-Cruz, J Melchor-Ruan, A Álvarez-Cano
INTRODUCTION: Medullary carcinoma accounts for 1-2% of all thyroid malignancies. 13-20% of patients present with distant metastasis, with 45% of the cases affecting the liver. CLINICAL CASE: A 50-year-old woman, diagnosed with medullary thyroid carcinoma, was treated with total thyroidectomy and a modified neck dissection in 1999. Two lymph node recurrences in the neck were treated with surgical resection; during surveillance, she developed elevated calcitonin levels, the recurrence site was identified with 18 F-DOPA PET/CT in the liver...
May 10, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29753758/lncrna-n335586-mir-924-ckmt1a-axis-contributes-to-cell-migration-and-invasion-in-hepatocellular-carcinoma-cells
#13
Hongxia Fan, Ping Lv, Ting Mu, Xiaopei Zhao, Yankun Liu, Yujie Feng, Jing Lv, Min Liu, Hua Tang
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide and chronic hepatitis B virus (HBV) infection is a major risk factor for HCC. Emerging evidences indicate that long noncoding RNAs (lncRNAs) play a pivotal role in HCC development, but its contribution to HBV-related HCC remains largely unclear. Differentially expressed lncRNAs in HBV-related HCC tissues were identified by deep sequencing in our previous study. The function of lncRNA n335586, one of most up-regulated lncRNAs in HBV-related HCC, was characterized in the present study...
May 10, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29742707/surgical-treatment-for-metastasis-from-lymphoepithelioma-like-cholangiocarcinoma-in-the-liver-a-case-report
#14
Jun-Wei Zhang, Hua-Yu Yang, Yi-Yao Xu, Xin-Ting Sang, Shuang-Ni Yu, Han-Chun Huang, Jin Bian, Jian-Ping Xiong, Xin Lu
RATIONALE: Lymphoepithelioma-like cholangiocarcinoma (LEL-CC) is a rare variant of intrahepatic cholangiocarcinoma (ICC), which is characterized by the better outcome than normal ICC. There is no report about the treatment for the metastasis of the LEL-CC. Here, we describe a rare case of LEL-CC of the liver and report the treatment for metastasis of it. PATIENT CONCERNS: A 38-year-old woman with a chronic hepatitis B infection was referred to the department of liver surgery in our hospital with a mass in the liver...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29742288/metastatic-breast-cancer-to-the-liver-with-hepatoid-features-and-hep-par-1-antibody-positive-mimicking-hepatocellular-carcinoma
#15
Authur Affleck, William B Lyman, W Carl Jacobs, Chad A Livasy, John B Martinie, David A Iannitti, Dionisios Vrochides
The hepatocyte paraffin 1 antibody (Hep Par 1) has a high positive predictive value for differentiating hepatocellular carcinoma from cholangiocarcinoma and metastatic carcinoma.1 We report a case of metastatic breast cancer to the liver with hepatoid histology and strong positive staining for Hep Par 1 mimicking hepatocellular carcinoma. To our knowledge, primary breast carcinoma staining Hep Par 1 positive has not been reported in the setting of hepatic metastasis. This article is protected by copyright. All rights reserved...
May 9, 2018: Histopathology
https://www.readbyqxmd.com/read/29741294/synaptotagmin-xiii-expression-and-peritoneal-metastasis-in-gastric-cancer
#16
M Kanda, D Shimizu, H Tanaka, C Tanaka, D Kobayashi, M Hayashi, H Takami, Y Niwa, S Yamada, T Fujii, H Sugimoto, Y Kodera
BACKGROUND: Peritoneal metastasis is a frequent cause of death in patients with gastric cancer. The aim of this study was to identify molecules responsible for mediating peritoneal metastasis of gastric cancer. METHODS: Transcriptome and bioinformatics analyses were conducted to identify molecules associated with peritoneal metastasis. The therapeutic effects of intraperitoneally administered small interfering (si) RNA were evaluated using mouse xenograft models...
May 9, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29738066/long-non-coding-rna-plncrna-1-promotes-cell-proliferation-and-hepatic-metastasis-in-colorectal-cancer
#17
Gui-Qing Jia, Ming-Ming Zhang, Kang Wang, Gao-Ping Zhao, Ming-Hui Pang, Zhe-Yu Chen
Emerging evidence has identified that long non-coding RNAs (lncRNAs) may play an important role in the pathogenesis of many cancer types, including colorectal cancer (CRC). However, the role of PlncRNA-1 in CRC remains unclear. The aim of our present study was to investigate the potential functions of PlncRNA-1 in CRC and to identify the underlying mechanisms of action. We demonstrated that up-regulated PlncRNA-1 in CRC tissues and cells promoted cell proliferation by accelerating cell cycle process and inhibiting cell apoptosis in vitro, enhanced tumor growth and matastasis in vivo and was associated with cell migration and invasion, EMT process of CRC cells...
May 8, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29731884/expression-of-microrna-638-and-sex-determining-region-y-box-2-in-hepatocellular-carcinoma-association-between-clinicopathological-features-and-prognosis
#18
Weikang Ye, Jieke Li, Guan Fang, Xiupeng Cai, Yan Zhang, Chaojun Zhou, Lei Chen, Wenjun Yang
The aim of the present study was to determine the expression profile of microRNA 638 (miR-638) and sex-determining region Y-box 2 (SOX2) in hepatocellular carcinoma (HCC), and to investigate their association with clinicopathological features and survival. Reverse transcription-quantitative polymerase chain reaction analysis was used to investigate miR-638 and SOX2 expression in 78 patients with HCC. Western blot and immunohistochemical analyses were performed in order to determine SOX2 protein expression in HCC samples...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29731866/microrna-hsa-let-7e-5p-as-a-potential-prognosis-marker-for-rectal-carcinoma-with-liver-metastases
#19
Wenfeng Chen, Guosheng Lin, Yizhou Yao, Jishen Chen, Hanli Shui, Qinghai Yang, Xiaoya Wang, Xiaoyuan Weng, Ling Sun, Fei Chen, Sheng Yang, Yufeng Yang, Yongjian Zhou
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that target mRNAs for translational repression or cleavage. The present study was conducted to identify differentially expressed miRNAs in primary tumor tissues of rectal carcinoma (RC) that may be associated with heterochrony hepatic metastasis (HHM). Samples were collected exclusively from patients with RC but not colon cancer (CC); Next-generation high-throughput sequencing technology and bioinformatics tools were used to profile and analyze small RNAs and their corresponding targets in primary tumor tissues with HHM (n=2) or without metastases (non-metastatic, NM; n=2)...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29728103/establishment-and-validation-of-a-predictive-nomogram-model-for-non-small-cell-lung-cancer-patients-with-chronic-hepatitis-b-viral-infection
#20
Shulin Chen, Yanzhen Lai, Zhengqiang He, Jianpei Li, Xia He, Rui Shen, Qiuying Ding, Hao Chen, Songguo Peng, Wanli Liu
BACKGROUND: This study aimed to establish an effective predictive nomogram for non-small cell lung cancer (NSCLC) patients with chronic hepatitis B viral (HBV) infection. METHODS: The nomogram was based on a retrospective study of 230 NSCLC patients with chronic HBV infection. The predictive accuracy and discriminative ability of the nomogram were determined by a concordance index (C-index), calibration plot and decision curve analysis and were compared with the current tumor, node, and metastasis (TNM) staging system...
May 4, 2018: Journal of Translational Medicine
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