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https://www.readbyqxmd.com/read/28078380/imaging-features-of-hepatic-sarcomatous-carcinoma-on-computed-tomography-and-gadoxetic-acid-enhanced-magnetic-resonance-imaging
#1
Kyo-Won Gu, Young Kon Kim, Ji Hye Min, Sang Yun Ha, Woo Kyoung Jeong
PURPOSE: To determine the imaging features of hepatic sarcomatous carcinoma including sarcomatous intrahepatic cholangiocarcinoma (S-ICC) and sarcomatous hepatocellular carcinoma (S-HCC) on computed tomography (CT) and gadoxetic acid-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: Twenty-four patients with pathologically confirmed S-ICCs (n = 13), S-HCCs (n = 7), sarcomatous carcinoma (n = 2), carcinosarcoma (n = 1), and sarcomatous combined HCC-CC (n = 1) (size range 2...
January 12, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28077172/promoting-effect-of-hepatitis-b-virus-on-the-expressoin-of-phospholipase-a2-group-iia
#2
Chengliang Zhu, Hui Song, Bingzheng Shen, Long Wu, Fang Liu, Xinghui Liu
BACKGROUND: Hepatitis B virus (HBV) infection causes acute and chronic liver disease, ultimately leading to the development of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Phospholipase A2 group IIA (PLA2G2A) plays important roles in the development and progression of many tumors. Thus far, there have been no reports on the association between HBV and PLA2G2A. The present study investigated the effect of HBV infection on PLA2G2A expression and its application in the diagnosis of HBV-related diseases...
January 11, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28061766/chemotherapy-induced-sinusoidal-injury-csi-score-a-novel-histologic-assessment-of-chemotherapy-related-hepatic-sinusoidal-injury-in-patients-with-colorectal-liver-metastasis
#3
Heather L Stevenson, Mariana M Prats, Eizaburo Sasatomi
BACKGROUND: Preoperative neoadjuvant therapy for colorectal liver metastases (CRLM) is increasing in use and can lead to chemotherapy-induced damage to sinusoidal integrity, namely sinusoidal obstruction syndrome (SOS). SOS has been associated with an increased need for intraoperative blood transfusions, increased length of hospitalization post-surgery, decreased tumor response, and a shorter overall survival after resection due to liver insufficiency. It is critical for clinicians and pathologists to be aware of this type of liver injury, and for pathologists to include the status of the background, non-neoplastic liver parenchyma in their pathology reports...
January 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28061471/transformation-to-small-cell-carcinoma-as-an-acquired-resistance-mechanism-to-azd9291-a-case-report
#4
Lin Li, Hui Wang, Chao Li, Zheng Wang, Ping Zhang, Xu Yan
AZD9291, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), benefits patients with T790M mutant non-small-cell lung cancer who fail treatment with first-generation EGFR TKIs. Acquisition of resistance to AZD9291 occurs inevitable and mechanisms need to be explored. We reported an advanced lung adenocarcinoma female with EGFR exon19 deletion treated on AZD9291 after failure of erlotinib and chemotherapy. Disease progressed again after 6 months' treatment of AZD9291 with hepatic metastasis...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28049374/needle-track-seeding-after-percutaneous-radiofrequency-ablation-of-hepatocellular-carcinoma-14-year-experience-at-a-single-center
#5
Zhong-Yi Zhang, Wei Yang, Kun Yan, Ying Dai, Wei Wu, Jung-Chieh Lee, Min-Hua Chen
PURPOSE: To determine the incidence, risk factors and prognosis associated with needle track seeding after percutaneous radiofrequency ablations(RFA) for hepatocellular carcinoma(HCC) with a long-term follow-up. MATERIALS AND METHODS: 741 HCC patients undergoing percutaneous RFA were retrospectively analyzed. Mean follow-up interval was 34.3±26.8 months. All seeding neoplasms were diagnosed by imaging modalities with or without pathological evaluation. Risk factors, including Child-Pugh grading, tumor size, number, location, serum AFP level, track number, biopsy before RFA and electrode type were performed by univariate analysis...
January 3, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28049244/false-positive-diagnosis-of-hepatocellular-carcinoma-in-liver-resection-patients
#6
Hongeun Lee, Jeong Hee Yoon, Hyeyoung Kim, Nam Joon Yi, Suk Kyun Hong, Kyung Chul Yoon, Hyo Sin Kim, Sung Woo Ahn, Jin Young Choi, Youngrok Choi, Hae Won Lee, Ju Yeon Yi, Kyoung Bun Lee, Kwang Woong Lee, Kyung Suk Suh
The diagnosis of hepatocellular carcinoma (HCC) is based on imaging studies particularly in high-risk patients without histologic confirmation. This study evaluated the prevalence and characteristics of false-positively diagnosed HCC in a liver resection cohort for HCC. A retrospective review was performed of 837 liver resection cases for clinically diagnosed HCC between 2005 and 2010 at our institute. High-risk patients with tumors > 1 cm with one or two image findings consistent with HCC and tumors < 1 cm with two or more image findings consistent with HCC with persistently increased serum alpha-fetoprotein (AFP) levels above the normal range with underlying inhibited hepatitis activity underwent liver resection...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28044957/right-hemihepatectomy-for-colon-cancer-metachronous-liver-metastasis-in-a-patient-with-crohn-s-disease-case-report-and-review-of-the-literature
#7
Ionuţ Negoi, Alexandru Runcanu, Sorin Paun, Mircea Beuran
: Introduction: Twenty percent of patients with colorectal cancer present stage IV disease at the time of diagnosis. The Crohn's disease increases 20 times the risk of colorectal cancer and worsens the patients' prognosis. The objective of this case report is to illustrate the surgical resection of a liver metachronous metastasis of colon cancer origin in a patient with Crohn's disease. CASE REPORT: A 53-year old female patient was admitted to our hospital for a colon cancer metachronous liver metastasis...
November 2016: Chirurgia
https://www.readbyqxmd.com/read/28031667/progression-of-thrombus-in-portal-vein-superior-mesenteric-vein-and-splenic-vein-even-on-anticoagulation-in-a-patient-with-ascending-colonic-malignancy-with-liver-metastasis-portal-vein-thrombosis-versus-portal-vein-tumor-thrombosis
#8
Ashish Sule, Annamarie Borja, Tay Jam Chin
Portal vein thrombosis (PVT) in a setting of liver metastasis is not easy to treat as it may be portal vein tumor thrombus (PVTT). A 77-year-old male patient was diagnosed as ascending colon carcinoma, underwent right hemicolectomy in 1991 with a recurrence in July 2009. In August 2009, he underwent computed tomography (CT) scan of the abdomen which showed evidence of superior mesenteric vein thrombosis with no liver metastasis. He was started with anticoagulation and decision was to treat long term. He was admitted with mesenteric artery ischemic symptoms in February 2012 on anticoagulation...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28031549/clinicopathological-features-and-prognosis-of-hepatic-epithelioid-hemangioendothelioma-after-liver-resection-and-transplantation
#9
Dong-Hwan Jung, Shin Hwang, Seung-Mo Hong, Ki-Hun Kim, Young-Joo Lee, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Gil-Chun Park, Eunsil Yu, Sung-Gyu Lee
BACKGROUND Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor. We present a single-center study on hepatic EHE cases treated by hepatic resection (HR) or liver transplantation (LT). MATERIAL AND METHODS Six HR patients with hepatic EHE were identified during 5 years from 2010 to 2014; EHE represented 0.13% (6 of 4572) of all primary liver tumors. Two LT recipients were also identified during 12 years from 2003 to 2014, who represented 0.06% (2 of 3576) of all adult LT patients. RESULTS Mean age of the patients was 42...
December 29, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28030943/is-there-a-rationale-for-aggressive-breast-cancer-liver-metastases-resections-in-polish-female-patients-analysis-of-overall-survival-following-hepatic-resection-at-a-single-centre-in-poland
#10
Eliza Kobryń, Konrad Kobryń, Tadeusz Wróblewski, Krzysztof Kobryń, Radosław Pietrzak, Paweł Rykowski, Bogna Ziarkiewicz-Wróblewska, Krzysztof Lamparski, Krzysztof Zieniewicz, Waldemar Patkowski, Marek Krawczyk, Rafał Paluszkiewicz
INTRODUCTION: Breast cancer (BC) makes up nearly 26% of malignant tumours worldwide and is the leading cause of cancer-related deaths in European women. With approximately 18,000 new cases of BC diagnosed in Polish women annually, breast cancer liver metastasis (BCLM) is respectively an increasing issue. Recent data found in literature indicates improved survival following liver resection with systemic therapy. OBJECTIVE: The aim of study was to evaluate surgical treatment in patients with isolated BCLM...
23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28030846/hepatitis-b-virus-associated-intrahepatic-cholangiocarcinoma-a-malignancy-of-distinctive-characteristics-between-hepatocellular-carcinoma-and-intrahepatic-cholangiocarcinoma
#11
REVIEW
Seogsong Jeong, Ying Tong, Meng Sha, Jinyang Gu, Qiang Xia
It has been a decade since hepatitis B virus infection was identified as an etiological factor for the development of intrahepatic cholangiocarcinoma (ICC). In recent years, several studies have elucidated the critical impact of hepatitis B virus in ICC that significantly influenced the clinicopathological characteristics of ICC patients with intrahepatic cholangiocarcinoma. Distinctive features of patients with hepatitis B virus-associated ICC included younger age, preponderance of male patients, frequent elevation of alpha-fetoprotein, and infrequent lymph node metastasis...
December 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/28025476/a-case-of-hepatocellular-carcinoma-presenting-as-a-gingival-mass
#12
Min Jung Kwon, Soo Hyung Ryu, Soo Yeon Jo, Chul Hoon Kwak, Won Jae Yoon, Jeong Seop Moon, Hye Kyung Lee
Oral metastatic tumor, which is uncommon and represents less than 1% of malignant oral neoplasms, usually arises from a primary mucosal or cutaneous cancer located in the head and neck regions. Metastasis of hepatocellular carcinoma (HCC) to the oral cavity, especially to gingiva, is extremely rare. A 50-year-old man, who was a chronic alcoholic and hepatitis B virus carrier, presented with abdominal distension and weight loss for the past 3 months. Three-phased contrast-enhanced abdominal CT revealed numerous conglomerated masses in the liver, suggesting huge HCCs arising in the background of liver cirrhosis with a large amount of ascites...
December 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28018701/metastatic-inflammatory-myofibroblastic-tumor-of-the-spleen-a-case-report-and-review-of-the-literature
#13
Luca Koechlin, Andreas Zettl, Dieter Koeberle, Markus von Flüe, Martin Bolli
Introduction. Inflammatory myofibroblastic tumors (IMT) of the spleen are rare neoplasms and only little is known about the origin and behavior of these tumors. Here we report the case of a 37-year-old woman with an atypical spindle cell neoplasm showing features strongly suggesting an IMT of the spleen with hepatic metastasis. Methods. A 37-year-old patient had been complaining about pain in the left upper abdomen for the last two months. A CT scan revealed a tumor mass in her spleen and liver. After complete staging, a splenectomy and atypical liver resection of segments VII and VIII were performed...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/28012330/synchronous-hepatic-metastasis-and-metachronous-krukenberg-tumor-from-advanced-colon-cancer-a-case-report-with-an-unexpected-disease-free-survival
#14
Giovanni Li Destri, Lidia Puzzo, Alessia Erika Russo, Francesco Ferraù, Antonio Di Cataldo, Stefano Puleo
BACKGROUND: In the international literature we have never found a long survival in patients treated for a colon cancer with synchronous hepatic metastases and for a metachronous Krukenberg tumor. PRESENTATION OF CASE: A 46-year old woman for an advanced colon cancer with a synchronous hepatic metastases was subjected to a left hemicolectomy and a resection of liver segment V (R0 resection; T4N2bM1; stage IVa according AJCC 2010). After one year a CT of the abdomen revealed an expansive formation of the left ovary...
November 23, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28006922/sister-mary-joseph-s-nodule-as-initial-pancreatic-cancer-manifestation
#15
Cristina Vallejo Bernad, María Carmen Casamayor Franco, Sofía Hakim Alonso
We report the case of an 85-year-old female patient who presented with umbilical pain associated with an indurated growth, the whole being apparently consistent with incarcerated umbilical hernia, which prompted an urgent surgical procedure for its removal. The pathology study revealed dermal infiltration by a malignancy. Gland tumor cells expressed an immunohistochemical profile initially consistent with a pancreatic origin. In view of these findings a CT scan was performed, which revealed a pancreatic tail tumor as well as multiple hepatic metastasis...
December 23, 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28004118/peg10-is-imperative-for-tgf-%C3%AE-1-induced-epithelial%C3%A2-mesenchymal-transition-in-hepatocellular-carcinoma
#16
Minfeng Zhang, Chengjun Sui, Binghua Dai, Weifeng Shen, Jiongjiong Lu, Jiamei Yang
Substantial evidence indicates that transforming growth factor-beta 1 (TGF-β1) plays a vital role in epithelial-mesenchymal transition (EMT). PEG10 has been shown involved in invasion and metastasis of tumors. The present study investigated the role of PEG10 in TGF-β1-triggered EMT in hepatocellular carcinoma (HCC) progression. Immunohistochemistry and real-time PCR were used to measure the expression level of PEG10 in clinical HCC tissues with or without lymph node metastasis, and normal tissues. The results showed that PEG10 expression is higher in HCC tissues and associated with overall survival (OS) and lymph node metastasis...
January 2017: Oncology Reports
https://www.readbyqxmd.com/read/28003723/multifocal-intrahepatic-artery-aneurysm-with-fdg-avid-thrombosis-simulating-metastasis-report-of-a-rare-case
#17
Xiaofei Zhang, Ashley E Stueck, Sander Florman, Swan N Thung, Sara Lewis
Hepatic artery aneurysm (HAA), although rare, represents a serious diagnostic and therapeutic challenge due to high rupture rate and associated mortality. Early detection and accurate diagnosis are essential for successful management. Here, we present an extremely rare case of multi-focal intrahepatic HAA with confined intrahepatic rupture and hypermetabolic activity at PET imaging, simulating metastasis of melanoma. A retrospective review found only two other HAA at our institution between 2000 and 2015, both of which involved the extrahepatic artery...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28001112/microwave-ablation-for-treatment-of-hepatic-neoplasia-in-five-dogs
#18
Toni Yang, J Brad Case, Sarah Boston, Michael J Dark, Beau Toskich
CASE DESCRIPTION 5 dogs between 9 and 11 years of age were evaluated for treatment of primary (n = 2) or metastatic (3) hepatic neoplasia. CLINICAL FINDINGS Patients were evaluated on an elective (n = 3) or emergency (2) basis. Two dogs with primary hepatic neoplasia were evaluated because of lethargy and inappetence. One dog was referred after an enlarged anal sac was detected via palpation per rectum during a routine physical examination. Two dogs were evaluated on an emergency basis because of lethargy and weakness, and hemoabdomen in the absence of a history of trauma was detected...
January 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27999917/radiofrequency-ablation-combined-with-hepatic-arterial-chemoembolization-using-degradable-starch-microsphere-mixed-with-mitomycin-c-for-the-treatment-of-liver-metastasis-from-colorectal-cancer-a-prospective-multicenter-study
#19
Koichiro Yamakado, Yasutaka Inaba, Yozo Sato, Taku Yasumoto, Sadao Hayashi, Takashi Yamanaka, Koji Nobata, Haruyuki Takaki, Atsuhiro Nakatsuka
PURPOSE: This phase II prospective study investigates possible benefits of radiofrequency ablation (RFA) combined with hepatic arterial chemoembolization using degradable starch microsphere (DSM) mixed with mitomycin C (MMC) in non-surgical candidates with colorectal liver metastases. MATERIALS AND METHODS: This study, approved by the respective institutional review board, included non-surgical candidates with 3 or fewer liver tumors of 3 cm or smaller, or a single lesion 5 cm or smaller...
December 20, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27990658/identification-of-liver-metastases-with-probe-based-confocal-laser-endomicroscopy-at-two-excitation-wavelengths
#20
Crispin Schneider, Sean P Johnson, Kurinchi Gurusamy, Richard J Cook, Adrien E Desjardins, David J Hawkes, Brian R Davidson, Simon Walker-Samuel
BACKGROUND: Metastasis of colorectal cancer to the liver is the most common indication for hepatic resection in a western population. Incomplete excision of malignancy due to residual microscopic disease normally results in worse patient outcome. Therefore, a method aiding in the real time discrimination of normal and malignant tissue on a microscopic level would be of benefit. MATERIAL AND METHODS: The ability of fluorescent probe-based confocal laser endomicroscopy (pCLE) to identify normal and malignant liver tissue was evaluated in an orthotopic murine model of colorectal cancer liver metastasis (CRLM)...
December 19, 2016: Lasers in Surgery and Medicine
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