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skeletal muscle quality

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https://www.readbyqxmd.com/read/29139538/limitations-of-the-pax7-creer-t2-transgene-for-driving-deletion-of-nf1-in-adult-mouse-muscle
#1
Matthew A Summers, Kathy Mikulec, Lauren Peacock, David G Little, Aaron Schindeler
Neurofibromatosis Type 1 (NF1) is an autosomal dominant genetic disorder that results in a variety of characteristic manifestations. Prior studies have shown reduced muscle size and global skeletal muscle weakness in children with NF1. This associated weakness can lead to significant challenges impacting on quality of life. Pre-clinical studies using a muscle-specific NF1 knockout mouse have linked this weakness to an underlying primary metabolic deficiency in the muscle. However, the neonatal lethality of this strain prevents analysis of the role of NF1 in adult muscle...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/29134152/the-role-of-mef2-transcription-factors-in-dehydration-and-anoxia-survival-in-rana-sylvatica-skeletal-muscle
#2
Myriam P Hoyeck, Hanane Hadj-Moussa, Kenneth B Storey
The wood frog (Rana sylvatica) can endure freezing of up to 65% of total body water during winter. When frozen, wood frogs enter a dormant state characterized by a cessation of vital functions (i.e., no heartbeat, blood circulation, breathing, brain activity, or movement). Wood frogs utilize various behavioural and biochemical adaptations to survive extreme freezing and component anoxia and dehydration stresses, including a global suppression of metabolic functions and gene expression. The stress-responsive myocyte enhancer factor-2 (MEF2) transcription factor family regulates the selective expression of genes involved in glucose transport, protein quality control, and phosphagen homeostasis...
2017: PeerJ
https://www.readbyqxmd.com/read/29131244/a-review-on-irisin-a-new-protagonist-that-mediates-muscle-adipose-bone-neuron-connectivity
#3
B Grygiel-Górniak, M Puszczewicz
Physical activity improves the quality of life and decreases the risk of several diseases (i.e. stroke, hypertension, myocardial infarction, obesity, and malignancies). Skeletal muscles are considered as an endocrine organ that produces myokines characterized by a paracrine or endocrine activity. Irisin is a circulating hormone-like myokine and is secreted as a product of fibronectin type III domain-containing protein 5 from skeletal muscle in response to exercise. This molecule regulates the energy metabolism and acts in adipose tissue, bones, and nervous system...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29130720/-relationship-between-quality-of-life-physical-activity-nutrition-glycemic-control-and-sarcopenia-in-older-adults-with-type-2-diabetes-mellitus
#4
Cristina Casals-Vázquez, Ernesto Suárez-Cadenas, Francisca María Estébanez Carvajal, María Pilar Aguilar Trujillo, María M Jiménez Arcos, María Ángeles Vázquez Sáchez
INTRODUCTION: The term sarcopenia is defined as age-related loss of skeletal muscle mass and function, with a consequent impact on quality of life. However, there is a lack of studies examining the prevalence of sarcopenia in patients with type 2 diabetes mellitus (DM). OBJECTIVES: To analyze the prevalence of sarcopenia in patients over 65 years with type 2 DM and the influence of physical activity, diet, glycemic control, sex, age, and quality of life. METHODS: A total of 279 patients (155 females), aged 76...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29129228/preoperative-low-muscle-mass-has-a-strong-negative-effect-on-pulmonary-function-in-patients-undergoing-living-donor-liver-transplantation
#5
Hisaya Shirai, Toshimi Kaido, Yuhei Hamaguchi, Siyuan Yao, Atsushi Kobayashi, Shinya Okumura, Naoko Kamo, Shintaro Yagi, Hideaki Okajima, Shinji Uemoto
OBJECTIVE: This study investigated the effect of preoperative sarcopenia on cardiopulmonary function in patients undergoing living donor liver transplantation (LDLT). METHODS: A retrospective analysis was performed of 207 patients who underwent LDLT between January 2008 and April 2015. The quantity and quality of skeletal muscle were evaluated by the psoas muscle mass index (PMI) and intramuscular adipose tissue content (IMAC), respectively, using preoperative computed tomography imaging...
January 2018: Nutrition
https://www.readbyqxmd.com/read/29126250/diabetic-microvascular-disease-an-endocrine-society-scientific-statement
#6
Eugene J Barrett, Zhenqi Liu, Mogher Khamaisi, George L King, Ronald Klein, Barbara E K Klein, Timothy M Hughes, Suzanne Craft, Barry I Freedman, Donald W Bowden, Aaron I Vinik, Carolina M Casellini
Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving. This statement reviews biochemical/cellular pathways involved in facilitating and abrogating microvascular injury. The statement summarizes the types of injury/dysfunction that occur in the three classical diabetes microvascular target tissues, the eye, the kidney, and the peripheral nervous system; the statement also reviews information on the effects of diabetes and insulin resistance on the microvasculature of skin, brain, adipose tissue, and cardiac and skeletal muscle...
November 8, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29122966/skeletal-muscle-function-during-the-progression-of-cancer-cachexia-in-the-male-apc-min-mouse
#7
Brandon N VanderVeen, Justin P Hardee, Dennis K Fix, James A Carson
While cancer-induced skeletal muscle wasting has been widely investigated, the drivers of cancer-induced muscle functional decrements are only beginning to be understood. Decreased muscle function impacts cancer patient quality of life and health status, and several potential therapeutics have failed in clinical trials due to a lack of functional improvement. Furthermore, systemic inflammation and intrinsic inflammatory signaling's role in the cachectic disruption of muscle function requires further investigation...
November 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29116490/impact-of-sarcopenic-obesity-on-failure-to-rescue-from-major-complications-following-pancreaticoduodenectomy-for-cancer-results-from-a-multicenter-study
#8
Nicolò Pecorelli, Giovanni Capretti, Marta Sandini, Anna Damascelli, Giulia Cristel, Francesco De Cobelli, Luca Gianotti, Alessandro Zerbi, Marco Braga
BACKGROUND: Failure to rescue (FTR) is a quality-of-care indicator in pancreatic surgery, but may also identify patients who may not tolerate major postoperative complications despite being treated with best available care. Previous studies found that high visceral adipose tissue-to-skeletal muscle ratio is associated with poor outcomes following pancreaticoduodenectomy (PD). The aim of the study is to assess the impact of sarcopenic obesity on occurrence of FTR from major complications in cancer patients undergoing PD...
November 7, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29110475/preslaughter-transport-effect-on-broiler-meat-quality-and-post-mortem-glycolysis-metabolism-of-muscles-with-different-fiber-types
#9
Xiaofei Wang, Jiaolong Li, Jiahui Cong, Xiangxing Chen, Xudong Zhu, Lin Zhang, Feng Gao, Guanghong Zhou
Preslaughter transport has been reported to decrease the quality of breast meat but not thigh meat of broilers. However, tissue-specific difference in glycogen metabolism between breast and thigh muscles of transported broilers has not been well studied. We thus investigated the differences in meat quality, adenosine phosphates, glycolysis, and bound key enzymes associated with glycolysis metabolism in skeletal muscles with different fiber types of preslaughter transported broilers during summer. Compared to a 0...
November 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29108826/physical-activity-and-autoimmune-diseases-get-moving-and-manage-the-disease
#10
REVIEW
Kassem Sharif, Abdulla Watad, Nicola Luigi Bragazzi, Micheal Lichtbroun, Howard Amital, Yehuda Shoenfeld
Physical activity, by definition, is any skeletal muscle body movement that results in energy expenditure. In the last few decades, a plethora of scientific evidences have accumulated and confirmed the beneficial role of physical activity as a modifiable risk factor for a wide variety of chronic diseases including cardiovascular diseases (CVDs), diabetes mellitus and cancer, among others. Autoimmune diseases are a heterogeneous group of chronic diseases, which occur secondary to loss of self-antigen tolerance...
November 3, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29096037/evaluation-of-pharmacokinetic-models-for-perfusion-imaging-with-dynamic-contrast-enhanced-magnetic-resonance-imaging-in-porcine-skeletal-muscle-using-low-molecular-weight-contrast-agents
#11
Stefan Hindel, Giorgos Papanastasiou, Peter Wust, Marc Maaß, Anika Söhner, Lutz Lüdemann
PURPOSE: Pharmacokinetic models for perfusion quantification with a low-molecular-weight contrast agent (LMCA) in skeletal muscle using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) were evaluated. METHODS: Tissue perfusion was measured in seven regions of interest (ROIs) placed in the total hind leg supplied by the femoral artery in seven female pigs. DCE-MRI was performed using a 3D gradient echo sequence with k-space sharing. The sequence was acquired twice, first after LMCA and then after blood pool contrast agent injection...
November 2, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29095521/vitamin-d-and-calcium-supplementation-skeletal-muscle-strength-and-serum-testosterone-in-young-healthy-adult-males-randomized-control-trial
#12
Soma Saha, Ravinder Goswami, Lakshmy Ramakrishnan, Vishnubhatla Sreenivas, Samrina Mahtab, Parmita Kar, Sunita Srinivasan, Namrata Singh, Upinderpal Singh
BACKGROUND: Cholecalciferol and/or calcium supplementation might increase skeletal-muscle strength and serum testosterone in young adult males. OBJECTIVE: We performed a randomized-control-trial assessing the effect of cholecalciferol/calcium on skeletal-muscle strength and serum testosterone in vitamin-D deficient young males. DESIGN: Two-by-two factorial RCT. SUBJECT AND INTERVENTION: Two-hundred and twenty-eight young males were block-randomized to 1) double-placebo, 2) calcium/placebo, 3) cholecalciferol/placebo, and 4) cholecalciferol/calcium...
November 2, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29094660/investigation-of-the-perilipin-5-gene-expression-and-association-study-of-its-sequence-polymorphism-with-meat-and-carcass-quality-traits-in-different-pig-breeds
#13
M Zappaterra, M Mazzoni, P Zambonelli, R Davoli
The growing request for healthier fatty acid composition of animal products is raising the necessity of a deeper knowledge of the main factors controlling fatty acids storage in muscle and backfat. Perilipin (PLIN) 5, and the whole Perilipin family, seem to play a crucial role in the regulation of lipids deposition as code for proteins coating intracellular lipid droplets surface. Nevertheless, the knowledge of these genes in pig is still incomplete. The present research was aimed at investigating in different pig breeds the PLIN5 gene, analysing its expression level and the associations of the variability in its downstream gene region with pork meat and carcass quality traits...
November 2, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29083447/animal-derived-protein-consumption-is-associated-with-muscle-mass-and-strength-in-community-dwellers-results-from-the-milan-expo-survey
#14
F Landi, R Calvani, M Tosato, A M Martone, A Picca, E Ortolani, G Savera, S Salini, M Ramaschi, R Bernabei, E Marzetti
OBJECTIVES: Behavioral factors, including protein intake, influence the quantity and quality of skeletal muscle. The aim of this study was to explore the relationship between animal-derived protein intake and muscle mass and function in a large sample of unselected community-dwellers. MATERIAL AND METHODS: The VIP (Very Important Protein) study, conducted during Expo 2015 in Milan, was a population survey aimed at assessing major health metrics in a population outside of the research setting, with a special focus on the relation between animal-derived protein intake and muscle mass and function...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29081501/the-effects-of-muscle-mass-and-muscle-quality-on-cardio-metabolic-risk-in-peripubertal-girls-a-longitudinal-study-from-childhood-to-early-adulthood
#15
S Cheng, P Wiklund
BACKGROUND: Increased cardio-metabolic risk is well documented in children and adolescents with obesity and normal weight obesity. However, the associations of muscle mass and muscle quality with cardio-metabolic risk, independent of weight status from childhood to adulthood, has not been examined. METHODS: 236 girls were followed from pre-puberty to early adulthood. Fat mass and lean mass of the whole body were assessed by a dual-energy X-ray absorptiometry; muscle cross-sectional area, muscle density (skeletal muscle fat content) of the lower leg by the peripheral quantitative computerized tomography (pQCT) and blood glucose, insulin, triglycerides and HDL cholesterol by enzymatic photometric methods...
October 30, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29075109/echo-intensity-of-the-rectus-femoris-in-stable-copd-patients
#16
Xiong Ye, Mingjie Wang, Hui Xiao
OBJECTIVE: The aim of this study was to investigate whether echo intensity of the rectus femoris when measured using ultrasound can distinguish muscles affected by COPD compared with healthy non-COPD affected muscles and whether the severity of ultrasonic abnormalities was associated with health-related quality of life (HRQoL). METHODS: Echo intensity, areas of the rectus femoris, and the thickness of quadriceps muscles were measured using ultrasound in 50 COPD outpatients and 21 age-matched non-COPD controls...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29061618/critical-care-cycling-study-cyclist-trial-protocol-a-randomised-controlled-trial-of-usual-care-plus-additional-in-bed-cycling-sessions-versus-usual-care-in-the-critically-ill
#17
Marc R Nickels, Leanne M Aitken, James Walsham, Adrian G Barnett, Steven M McPhail
INTRODUCTION: In-bed cycling with patients with critical illness has been shown to be safe and feasible, and improves physical function outcomes at hospital discharge. The effects of early in-bed cycling on reducing the rate of skeletal muscle atrophy, and associations with physical and cognitive function are unknown. METHODS AND ANALYSIS: A single-centre randomised controlled trial in a mixed medical-surgical intensive care unit (ICU) will be conducted. Adult patients (n=68) who are expected to be mechanically ventilated for more than 48 hours and remain in ICU for a further 48 hours from recruitment will be randomly allocated into either (1) a usual care group or (2) a group that receives usual care and additional in-bed cycling sessions...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29061108/uncovering-the-embryonic-development-related-proteome-and-metabolome-signatures-in-breast-muscle-and-intramuscular-fat-of-fast-and-slow-growing-chickens
#18
Ranran Liu, Hongyang Wang, Jie Liu, Jie Wang, Maiqing Zheng, Xiaodong Tan, Siyuan Xing, Huanxian Cui, Qinghe Li, Guiping Zhao, Jie Wen
BACKGROUND: Skeletal muscle development is closely linked to meat production and its quality. This study is the first to quantify the proteomes and metabolomes of breast muscle in two distinct chicken breeds at embryonic day 12 (ED 12), ED 17, post-hatch D 1 and D 14 using mass spectrometry-based approaches. RESULTS: Results found that intramuscular fat (IMF) accumulation increased from ED 17 to D 1 and that was exactly the opposite of when most obvious growth of muscle occurred (ED 12 - ED 17 and D 1 - D 14)...
October 23, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29059722/genome-wide-association-study-reveals-genetic-loci-and-candidate-genes-for-average-daily-gain-in-duroc-pigs
#19
Jianping Quan, Rongrong Ding, Xingwang Wang, Ming Yang, Yang Yang, Enqin Zheng, Ting Gu, Gengyuan Cai, Zhenfang Wu, Dewu Liu, Jie Yang
Objective: Average daily gain (ADG) is an important target trait of pig breeding programs. We aimed to identify single nucleotide polymorphisms (SNPs) and genomic regions that are associated with ADG in the Duroc pig population. Methods: We performed a genome-wide association study involving 390 Duroc boars and by using the PorcineSNP60K Beadchip and two linear models. Results: After quality control, we detected 35971 SNPs, which included seven SNPs that are significantly associated with the ADG of pigs...
October 20, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29059617/the-combination-of-four-analytical-methods-to-explore-skeletal-muscle-metabolomics-better-coverage-of-metabolic-pathways-or-a-marketing-argument
#20
C Bruno, F Patin, C Bocca, L Nadal-Desbarats, F Bonnier, P Reynier, P Emond, P Vourc'h, K Joseph-Delafont, P Corcia, C R Andres, H Blasco
OBJECTIVES: Metabolomics is an emerging science based on diverse high throughput methods that are rapidly evolving to improve metabolic coverage of biological fluids and tissues. Technical progress has led researchers to combine several analytical methods without reporting the impact on metabolic coverage of such a strategy. The objective of our study was to develop and validate several analytical techniques (mass spectrometry coupled to gas or liquid chromatography and nuclear magnetic resonance) for the metabolomic analysis of small muscle samples and evaluate the impact of combining methods for more exhaustive metabolite covering...
October 18, 2017: Journal of Pharmaceutical and Biomedical Analysis
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