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https://www.readbyqxmd.com/read/27672515/a-post-honeymoon-measles-epidemic-in-burundi-mathematical-model-based-analysis-and-implications-for-vaccination-timing
#1
Katelyn C Corey, Andrew Noymer
Using a mathematical model with realistic demography, we analyze a large outbreak of measles in Muyinga sector in rural Burundi in 1988-1989. We generate simulated epidemic curves and age × time epidemic surfaces, which we qualitatively and quantitatively compare with the data. Our findings suggest that supplementary immunization activities (SIAs) should be used in places where routine vaccination cannot keep up with the increasing numbers of susceptible individuals resulting from population growth or from logistical problems such as cold chain maintenance...
2016: PeerJ
https://www.readbyqxmd.com/read/27611181/nonmotor-symptoms-in-parkinson-s-disease-are-we-still-waiting-for-the-honeymoon
#2
C Colosimo, R Bhidayasiri
No abstract text is available yet for this article.
November 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27503178/effect-of-autoimmunity-risk-loci-on-the-honeymoon-phase-in-type-1-diabetes
#3
Mandana Moosavi, Jade Séguin, Constantin Polychronakos
OBJECTIVE: To analyze the correlation between duration and depth of honeymoon phase in patients with type 1 diabetes (T1DM) and autoimmunity risk loci. METHODS: From a database of 567 individuals with clinical data, we selected 210 patients for whom we had dense genotyping results of single-nucleotide polymorphisms (SNPs) from our previous genome-wide association studies (GWAS) or targeted genotyping data. Using PLINK software, we analyzed the association between time spent in honeymoon phase as our quantitative trait, and 24 known autoimmunity predisposing SNPs...
August 9, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27435448/the-non-motor-side-of-the-honeymoon-period-of-parkinson-s-disease-and-its-relationship-with-quality-of-life-a-4-year-longitudinal-study
#4
R Erro, M Picillo, C Vitale, M Amboni, M Moccia, G Santangelo, M T Pellecchia, P Barone
BACKGROUND AND PURPOSE: Very little is known about the progression of non-motor symptoms (NMSs) in Parkinson's disease (PD) and there are no longitudinal studies exploring this topic from the earliest stage, when patients receive the diagnosis. We here report on the progression of NMSs over 4 years from diagnosis in a cohort of de-novo, previously untreated, patients with PD. METHODS: Consecutive de-novo (disease duration < 2 years), untreated patients with PD were enrolled in this observational study...
November 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27252867/pancreas-protective-effect-of-rituximab-for-acute-onset-type-1-diabetes-in-the-honeymoon-period-a-case-report
#5
Akira Kurozumi, Yosuke Okada, Tadashi Arao, Yusuke Miyazaki, Maiko Yoshikawa, Keiichi Torimoto, Satoshi Kubo, Shingo Nakayamada, Yoshiya Tanaka
UNLABELLED: A randomized controlled study of rituximab demonstrated that the drug protects pancreatic function in patients with acute-onset type 1 diabetes mellitus (AOT1DM). However, the mechanism of this protective effect is poorly understood. We examined the effects of rituximab in two patients with AOT1DM in the honeymoon period and the mechanism of these effects. Case 1 was a 40-year-old man and Case 2 was a 45-year-old man, both diagnosed with AOT1DM. Various tests indicated intact capacity for endogenous insulin secretion and that they were in the honeymoon phase of AOT1DM...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27237233/truth-behind-the-rumours
#6
(no author information available yet)
The honeymoon's over for Health Secretary Virginia Bottomley. Like her predecessors Messrs Waldegrave and Clarke, she's found herself in the firing line of some very unpopular decisions.
November 10, 1992: Nursing Standard
https://www.readbyqxmd.com/read/27173938/low-frequency-deep-brain-stimulation-for-parkinson-s-disease-great-expectation-or-false-hope
#7
REVIEW
Lazzaro di Biase, Alfonso Fasano
The long-term efficacy of subthalamic deep brain stimulation for Parkinson's disease is not always retained, and many patients lose the improvement achieved during the "second honeymoon" following surgery. Deep brain stimulation is a versatile tool, as stimulation parameters may undergo a fine-tuning depending on clinical needs. Among them, frequency is the parameter that leads to more complex scenarios because there is no generalizable relationship between its modulation and the overall clinical response, which also depends on the specific considered sign...
July 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/26998905/effect-of-natalizumab-on-brain-atrophy-and-disability-progression-in-multiple-sclerosis-patients-over-5-years
#8
R Zivadinov, D Hojnacki, N Bergsland, C Kennedy, J Hagemeier, R Melia, D P Ramasamy, J Durfee, E Carl, M G Dwyer, B Weinstock-Guttman
BACKGROUND AND PURPOSE: The long-term benefit of natalizumab on brain atrophy progression in multiple sclerosis (MS) patients is unknown. Our aim was to investigate its effect over 5 years. METHODS: This prospective study included 60 relapsing MS patients who started natalizumab treatment in years 2006-2007. RESULTS: At the 5-year follow-up, 20 patients discontinued natalizumab after an average of 29.5 cycles, 27 continued natalizumab treatment with some periods of honeymoon (average of 38...
June 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/26947770/influence-of-initial-insulin-dosage-on-blood-glucose-dynamics-of-children-and-adolescents-with-newly-diagnosed-type-1-diabetes-mellitus
#9
Yi Wang, Chunxiu Gong, Bingyan Cao, Xi Meng, Liya Wei, Di Wu, Xuejun Liang, Wenjing Li, Min Liu, Yi Gu, Chang Su
OBJECTIVE: To investigate the effect of initial insulin dosage on blood glucose (BG) dynamics, β-cell protection, and oxidative stress in type 1 diabetes mellitus. METHODS: Sixty newly diagnosed type 1 diabetes mellitus patients were randomly assigned to continuous subcutaneous insulin infusions of 0.6 ± 0.2 IU/kg/d (group 1), 1.0 ± 0.2 IU/kg/d (group 2), or 1.4 ± 0.2 IU/kg/d (group 3) for 3 wk. BG was monitored continuously for the first 10 d and the last 2 d of wk 2 and 3...
March 6, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/26944513/addressing-the-need-for-mental-health-screening-of-newly-resettled-refugees-a-pilot-project
#10
Kelly Polcher, Susan Calloway
BACKGROUND AND PURPOSE: Refugees resettling to the United States are at increased risk for mental health disorders, which can lead to difficulty with adaptation and poor health outcomes. Standardized mental health screening of refugees is often neglected at primary care and community health clinics. A pilot project aimed to initiate early mental health screening for newly resettled adult refugees was implemented at a community health center in Fargo, North Dakota. METHODS: Current refugee screening processes were evaluated to determine appropriate timing for refugee mental health screening...
July 2016: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/26831335/greater-improvement-in-lrrk2-g2019s-patients-undergoing-subthalamic-nucleus-deep-brain-stimulation-compared-to-non-mutation-carriers
#11
RANDOMIZED CONTROLLED TRIAL
Massiva Sayad, Mohamed Zouambia, Malika Chaouch, Farida Ferrat, Mustapha Nebbal, Mohamed Bendini, Suzanne Lesage, Alexis Brice, Mohamed Brahim Errahmani, Boualem Asselah
BACKGROUND: Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) of parkinson's disease (PD) patients has demonstrated to improve motor performance and to reduce dopa-induced dyskinesia. An association between the occurrence of dyskinesias and LRRK2 (leucine-rich repeat kinase 2) G2019S gene mutations has recently been suggested. The aim of this study is to discover the impact of the G2019S mutation (with high incidence in the authors' native Algeria) on the symptom response of PD in patients who underwent STN-DBS...
February 1, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/26820572/-when-the-honeymoon-is-over-the-real-work-begins-gastric-bypass-patients-weight-loss-trajectories-and-dietary-change-experiences
#12
Amanda Lynch
To understand gastric bypass patients' experiences with managing food and eating for long-term weight management, this study examined patients' self-reported dietary changes and weight loss patterns. Thirteen women and three men between 15 months and 10 years post-gastric bypass surgery were recruited in Upstate New York. They completed two qualitative, in-depth interviews about their weight loss and dietary experiences. Using verbatim transcripts, researchers created timelines for each participant that summarized weight changes and the associated dietary behaviors...
February 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/26787439/anatomy-and-physiology-in-ischaemic-heart-disease-a-second-honeymoon
#13
EDITORIAL
Gianluca Pontone
No abstract text is available yet for this article.
April 14, 2016: European Heart Journal
https://www.readbyqxmd.com/read/26686766/the-relationship-between-female-genital-cutting-and-sexual-problems-experienced-in-the-first-two-months-of-marriage
#14
Mahmoud A Abdel-Aleem, Magdy M Elkady, Yaser A Hilmy
OBJECTIVE: To examine the relationship between female genital cutting (FGC) and sexual problems experienced by couples in the first 2 months of marriage ("honeymoon distress"). METHODS: A multicenter cross-sectional study was conducted at centers in Assiut and Sohag, Egypt, between March 1, 2011, and March 31, 2014. Eligible couples presented with sexual problems during the first 2 months of marriage. Couples were interviewed and asked to complete a pre-designed questionnaire, and a genital examination was performed...
March 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26653254/novel-strategies-for-inducing-glycemic-remission-during-the-honeymoon-phase-of-type-2-diabetes
#15
REVIEW
Ravi Retnakaran
A lofty goal in the management of type 2 diabetes is the achievement of glycemic remission. Glycemic remission can be defined as the sustained maintenance of normoglycemia without antidiabetic therapy for variable periods of time after stopping an initial disease-modifying intervention. Although this goal remains largely elusive at this time, growing recognition of the potential reversibility of pancreatic beta-cell dysfunction early in the course of type 2 diabetes has yielded a target for such disease modification...
December 2015: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/26568895/patterns-of-marital-relationship-change-across-the-transition-from-one-child-to-two
#16
Brenda L Volling, Wonjung Oh, Richard Gonzalez, Patty X Kuo, Tianyi Yu
Patterns of marital change after the birth of a second child were explored in a sample of 229 married couples, starting in pregnancy, and at 1, 4, 8 and 12 months postpartum. Five trajectory patterns that reflected sudden, persistent decline (i.e., crisis), sudden, short-term decline (i.e., adjustment and adaptation), sudden, short-term gain (i.e., honeymoon effect), linear change, and no change were examined with dyadic, longitudinal data for husbands and wives. Six distinct latent classes emerged using growth mixture modeling: (a) wife decreasing positivity-husband honeymoon (44%), (b) wife increasing conflict-husband adjustment and adaptation (34...
September 2015: Couple & Family Psychology
https://www.readbyqxmd.com/read/26504181/what-is-the-role-of-3%C3%A2-t-mri-in-sports-medicine-revisiting-the-marriage-after-the-honeymoon
#17
EDITORIAL
Frank W Roemer, Ali Guermazi
No abstract text is available yet for this article.
August 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/26486109/spontaneous-complete-remission-of-type-1-diabetes-mellitus-in-an-adult-review-and-case-report
#18
Harsha Moole, Vishnu Moole, Adrija Mamidipalli, Sowmya Dharmapuri, Raghuveer Boddireddy, Deepak Taneja, Hady Sfeir, Sonia Gajula
Type 1 diabetes mellitus (T1DM) is an autoimmune condition that results in low plasma insulin levels by destruction of beta cells of the pancreas. As part of the natural progression of this disease, some patients regain beta cell activity transiently. This period is often referred to as the 'honeymoon period' or remission of T1DM. During this period, patients manifest improved glycemic control with reduced or no use of insulin or anti-diabetic medications. The incidence rates of remission and duration of remission is extremely variable...
2015: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/26440526/exponential-increase-of-glutamic-acid-decarboxylase-gad-antibody-titer-after-initiating-and-stopping-insulin-in-a-patient-with-slowly-progressive-type-1-diabetes
#19
Akihiro Nishimura, Kaoru Nagasawa, Minoru Okubo, Tetsuro Kobayashi, Yasumichi Mori
Few articles have described fluctuations in glutamic acid decarboxylase antibody (GADAb) levels after a diagnosis of slowly progressive type 1 diabetes (SPIDDM). Here, we present a case in which GADAb levels exponentially increased after initiating and stopping insulin. A 64-year-old female patient newly diagnosed with SPIDDM was admitted and started multiple daily insulin injections. The patient's GADAb titer was 6.9 U/mL (normal: <1.4 U/mL) and the patient had a type 1 diabetes susceptible HLA class II haplotype known in the Japanese population as: DRB1*04:05-DQB1*04:01...
2015: Endocrine Journal
https://www.readbyqxmd.com/read/26271890/continuum-model-of-t-cell-avidity-understanding-autoreactive-and-regulatory-t-cell-responses-in-type-1-diabetes
#20
Majid Jaberi-Douraki, Massimo Pietropaolo, Anmar Khadra
Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction of insulin-secreting pancreatic β cells, leading to abolition of insulin secretion and onset of diabetes. Cytotoxic CD4(+) and CD8(+) T cells, activated by antigen presenting cells (APCs), are both implicated in disease onset and progression. Regulatory T cells (Tregs), on the other hand, play a leading role in regulating immunological tolerance and resistant homoeostasis in T1D by suppressing effector T cells (Teffs). Recent data indicates that after activation, conventional Teffs transiently produce interleukin IL-2, a cytokine that acts as a growth factor for both Teffs and Tregs...
October 21, 2015: Journal of Theoretical Biology
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