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https://www.readbyqxmd.com/read/28340528/znfe2o4-nanotapers-slag-assistant-growth-and-enhanced-photoelectrochemical-efficiency
#1
Xuefeng She, Zhuo Zhang
In this study, ZnFe2O4 (ZFO) nanotapers are fabricated on the ZnO nanorods (NRs) by recycling rare-earth oxide (REO) slag as the iron source, which thereby exhibits dramatically enhanced photoelectrochemical (PEC) efficiency. Our studies demonstrate that the electron-hole separation and charge migration can be facilitated by the cascade band alignment of ZFO and ZnO and the branched nanotaper structures. Not only the iron source, the slag particles can also act as the passivation layers, leading to improved electron lifetime and significant PEC enhancement...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28340520/galangin-inhibits-human-osteosarcoma-cells-growth-by-inducing-transforming-growth-factor-%C3%AE-1-dependent-osteogenic-differentiation
#2
Chunhong Liu, Mingming Ma, Junde Zhang, Shaoliu Gui, Xiaohai Zhang, Shuangtao Xue
Osteosarcoma is the most common primary malignancy of the musculoskeletal system, and is associated with excessive proliferation and poor differentiation of osteoblasts. Currently, despite the use of traditional chemotherapy and radiotherapy, no satisfactory and effective agent has been developed to treat the disease. Herein, we found that a flavonoid natural product, galangin, could significantly attenuate human osteosarcoma cells proliferation, without causing obvious cell apoptosis. Moreover, galangin enhanced the expression of osteoblast differentiation markers (collagen type I, alkaline phosphatase, osteocalcin and osteopontin) remarkably and elevated the alkaline phosphatase activity in human osteosarcoma cells...
March 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28340476/temporal-patterns-of-co2-and-ch4-in-a-rural-area-in-northern-spain-described-by-a-harmonic-equation-over-2010-2016
#3
Beatriz Fernández-Duque, Isidro A Pérez, M Luisa Sánchez, M Ángeles García, Nuria Pardo
The present paper seeks to improve our knowledge concerning the evolution of CO2 and CH4 in terms of monthly trends, growth rate and seasonal variations in the lower atmosphere. Dry continuous measurements of CO2 and the CH4 mixing ratio were carried out over five and a half years (from 15 October 2010 to 29 February 2016) by multi-point sampling at 1.8, 3.7 and 8.3m, using a Picarro analyzer at a rural site in the Low Atmosphere Research Centre (CIBA), on the upper Spanish plateau. Data were divided into diurnal and nocturnal records...
March 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28340475/irinotecan-upregulates-fibroblast-growth-factor-receptor-3-expression-in-colorectal-cancer-cells-which-mitigates-irinotecan-induced-apoptosis
#4
Zeynep N Erdem, Stefanie Schwarz, Daniel Drev, Christine Heinzle, Andrea Reti, Petra Heffeter, Xenia Hudec, Klaus Holzmann, Bettina Grasl-Kraupp, Walter Berger, Michael Grusch, Brigitte Marian
BACKGROUND: Irinotecan (IRI) is an integral part of colorectal cancer (CRC) therapy, but response rates are unsatisfactory and resistance mechanisms are still insufficiently understood. As fibroblast growth factor receptor 3 (FGFR3) mediates essential survival signals in CRC, it is a candidate gene for causing intrinsic resistance to IRI. METHODS: We have used cell line models overexpressing FGFR3 to study the receptor's impact on IRI response. For pathway blockade, a dominant-negative receptor mutant and a small molecule kinase inhibitor were employed...
March 21, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28340469/characterization-and-expression-patterns-of-key-c4-photosynthetic-pathway-genes-in-bread-wheat-triticum-aestivum-l-under-field-conditions
#5
Daoura Goudia Bachir, Iqbal Saeed, Quanhao Song, Tay Zar Linn, Liang Chen, Yin-Gang Hu
Wheat is a C3 plant with relatively low photosynthetic efficiency and is a potential target for C4 photosynthetic pathway engineering. Here we reported the characterization of four key C4 pathway genes and assessed their expression patterns and enzymatic activities at three growth stages in flag leaves of 59 bread wheat genotypes. The C4-like genes homologous to PEPC, NADP-ME, MDH, and PPDK in maize were identified in the A, B, and D sub-genomes of bread wheat, located on the long arms of chromosomes 3 and 5 (TaPEPC), short arms of chromosomes 1 and 3 (TaNADP-ME), long arms of chromosomes 1 and 7 (TaMDH), and long arms of chromosome 1 (TaPPDK), respectively...
March 9, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28340459/transcriptional-profiling-of-porcine-granulosa-cells-exposed-to-2-3-7-8-tetrachlorodibenzo-p-dioxin
#6
Agnieszka Sadowska, Anna Nynca, Monika Ruszkowska, Lukasz Paukszto, Kamil Myszczynski, Karina Orlowska, Sylwia Swigonska, Tomasz Molcan, Jan P Jastrzebski, Renata E Ciereszko
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic man-made chemical compound contaminating the environment. An exposure of living organisms to TCDD may result in numerous disorders, including reproductive pathologies. The aim of the current study was to examine the effects of TCDD on the transcriptome of porcine granulosa cell line AVG-16. By employing next-generation sequencing (NGS) we aimed to identify genes potentially involved in the mechanism of TCDD action and toxicity in porcine granulosa cells...
March 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28340458/toxic-effects-of-environmental-pollutants-comparative-investigation-using-allium-cepa-l-and-lactuca-sativa-l
#7
Graciele Lurdes Silveira, Maria Gabriela Franco Lima, Gabriela Barreto Dos Reis, Marcel José Palmieri, Larissa Fonseca Andrade-Vieria
Studies that help understand the mechanisms of action of environmental pollutants are extremely important in environmental toxicology. In this context, assays using plants as models stand out for their simplicity and low performance cost. Among the plants used for this purpose, Allium cepa L. is the model most commonly applied for cytogenotoxic tests, while Lactuca sativa L., already widely used in phytotoxic investigations, has been gaining prominence in cytotoxic analyses. The present study aimed to compare the responses of A...
March 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28340452/a-study-of-photosynthetic-biogas-upgrading-based-on-a-high-rate-algal-pond-under-alkaline-conditions-influence-of-the-illumination-regime
#8
Mariana Franco-Morgado, Cynthia Alcántara, Adalberto Noyola, Raúl Muñoz, Armando González-Sánchez
Microalgal-bacterial processes have emerged as environmental friendly systems for the cost-effective treatment of anaerobic effluents such as biogas and nutrients-laden digestates. Environmental parameters such as temperature, irradiation, nutrient concentration and pH effect the performance of the systems. In this paper, the potential of a microalgal-bacterial photobioreactor operated under high pH (≈9.5) and high alkalinity to convert biogas into biomethane was evaluated. The influence of the illumination regime (continuous light supply vs 12h/12h light/dark cycles) on the synthetic biogas upgrading efficiency, biomass productivity and nutrient removal efficiency was assessed in a High-Rate Algal Pond interconnected to a biogas absorption bubble column...
March 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28340437/assessment-of-microalga-biofilms-for-simultaneous-remediation-and-biofuel-generation-in-mine-tailings-water
#9
H Palma, E Killoran, M Sheehan, F Berner, K Heimann
Microalgae crops can generate a biochemical profile of high energy density and may be used for remediation of contaminated waste waters. This manuscript presents a laboratory-scale investigation into the potential for growing endemic microalgae biofilms in phosphorus-enriched nickel refinery tailings water, with an emphasis on product potential and the remediation of heavy metals. The dominant species of the consortia was a Chlorella-like microalga. The growth was monitored over time, with a productivity (0...
March 11, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28340433/feasibility-of-carbon-dioxide-sequestration-by-spongiochloris-sp-microalgae-during-petroleum-wastewater-treatment-in-airlift-bioreactor
#10
Abdeldjalil Abid, Faten Saidane, Moktar Hamdi
The aim of this work was to study the ability of using Hydrocabonoclastic native microbial and Spongiochloris sp microalgae in airlift bioreactors couples in order to restore hydrocarbons wastewater and develop the capacity of natural systems to reduce greenhouse effect through maximal control of CO2 gas emission in atmosphere. The kinetic parameters of CO2 gas fixation level and conversion it into biological material by microalgae as the biodegradation process effect in hydrocarbon have been evaluated. The result present that maximum specific growth rate μmax of Spongiochloris sp was (0...
March 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28340412/discovery-of-2-substituted-1h-benzo-d-immidazole-4-carboxamide-derivatives-as-novel-poly-adp-ribose-polymerase-1-inhibitors-with-in%C3%A2-vivo-anti-tumor-activity
#11
Jie Zhou, Ming Ji, Zhixiang Zhu, Ran Cao, Xiaoguang Chen, Bailing Xu
Novel 1H-benzo[d]immidazole-4-carboxamide derivatives bearing five-membered or six-membered N-heterocyclic moieties at the 2-position were designed and synthesized as PARP-1 inhibitors. Structure-activity relationships were conducted and led to a number of potent PARP-1 inhibitors having IC50 values in the single or double digit nanomolar level. Some potent PARP-1 inhibitors also had similar inhibitory activities against PARP-2. Among all the synthesized compounds, compound 10a and 11e displayed strong potentiation effects on temozolomide (TMZ) in MX-1 cells (PF50 = 7...
March 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28340398/proteomics-analysis-of-maize-zea-mays-l-grain-based-on-itraq-reveals-molecular-mechanisms-of-poor-grain-filling-in-inferior-grains
#12
Tao Yu, Geng Li, Peng Liu, Shuting Dong, Jiwang Zhang, Bin Zhao
In maize, inferior grains (IG) located on the upper part of the ear have poor grain filling process compared to superior grains (SG) located on the middle and lower parts of the ear. This difference limits satisfactory yield and quality; however, the underlying molecular mechanisms remain unknown. Here, using the isobaric tag for relative and absolute quantification (iTRAQ) technology, the proteomes of IG and SG during early and middle grain filling stages were investigated. In total, 4720 proteins were identified in maize grain and 305 differentially accumulated proteins (DiAPs) were detected between IG and SG...
March 11, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28340378/current-fda-approved-treatments-for-non-small-cell-lung-cancer-and-potential-biomarkers-for-its-detection
#13
REVIEW
Karla A Ruiz-Ceja, Yolanda I Chirino
BACKGROUND: Lung cancer is the leading worldwide cancer with almost 1.5 million deaths every year. Some drugs for lung cancer treatment have been available on the market for decades, but novel drugs have emerged promising better outcomes, especially for Non-Small Cell Lung Cancer (NSCLC), which represents 75% of lung cancer cases. However, how much do drugs have evolved for NSCLC treatment? Are they sharing the same mechanism of action? AIM: In this review we analyzed how the approved drugs by Federal Drug Agency for NSCLC have advanced in the last four decades identifying shared mechanism of action of medicines against NSCLC treatment and some of the potential biomarkers for early detection...
March 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28340328/the-role-of-auxin-response-factors-in-the-development-and-differential-growth-of-inflorescence-stems
#14
Nicholas S Carey, Naden T Krogan
Plants react to environmental cues by altering their growth and development, which can include organ tropic responses. These differential growth responses are triggered by the hormone auxin, and AUXIN RESPONSE FACTORs (ARFs) have been implicated in numerous organ tropisms in Arabidopsis thaliana. Surprisingly, despite being critical for light capture and overall plant morphology, inflorescence stem tropic responses remain relatively understudied, with presumed direct links to ARF function yet to be established...
March 24, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28340327/polymorphic-responses-of-medicago-truncatula-accessions-to-potassium-deprivation
#15
Kevin Garcia, Jean-Michel Ané
Potassium (K(+)) is an essential macronutrient for plants and the most abundant cation in cells. Due to variable K(+) availability in the environment, plants must be able to adjust their developmental, physiological and transcriptional responses. The plant development to K(+) deprivation was not well studied in legumes thus far. We recently described the first adaptation mechanisms of the model legume Medicago truncatula Jemalong A17 to long-term K(+) deprivation and analyzed these responses in the context of arbuscular mycorrhizal symbiosis...
March 24, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28340297/atomic-scale-snapshots-of-the-formation-and-growth-of-hollow-ptni-c-nanocatalysts
#16
Raphael Chattot, Tristan Asset, Jakub Drnec, Pierre Bordet, Jaysen Nelayah, Laetitia Dubau, Frédéric Maillard
Determining the formation and growth mechanism of bimetallic nanoparticles (NPs) with atomic detail is fundamental to synthesize efficient 'catalysts by design'. However, the understanding of the elementary steps, which take place during their synthesis remains elusive. Herein, we have exploited scanning transmission electron microscopy coupled to energy dispersive X-ray spectroscopy, operando wide angle and small angle X-ray scattering and electrochemistry to unveil the formation and growth mechanism of hollow PtNi/C NPs...
March 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28340243/finite-time-parametric-identification-for-the-model-representing-the-metabolic-and-genetic-regulatory-effects-of-sequential-aerobic-respiration-and-anaerobic-fermentation-processes-in-escherichia-coli
#17
Alfonso Sepúlveda-Gálvez, Jesús Agustín Badillo-Corona, Isaac Chairez
Mathematical modelling applied to biological systems allows for the inferring of changes in the dynamic behaviour of organisms associated with variations in the environment. Models based on ordinary differential equations are most commonly used because of their ability to describe the mechanisms of biological systems such as transcription. The disadvantage of using this approach is that there is a large number of parameters involved and that it is difficult to obtain them experimentally. This study presents an algorithm to obtain a finite-time parameter characterization of the model used to describe changes in the metabolic behaviour of Escherichia coli associated with environmental changes...
March 17, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/28340236/diet-density-during-the-first-week-of-life-effects-on-energy-and-nitrogen-balance-characteristics-of-broiler-chickens
#18
D M Lamot, D Sapkota, P J A Wijtten, I van den Anker, M J W Heetkamp, B Kemp, H van den Brand
This study aimed to determine effects of diet density on growth performance, energy balance, and nitrogen balance characteristics of broiler chickens during the first wk of life. Effects of diet density were studied using a dose-response design consisting of 5 dietary fat levels (3.5, 7.0, 10.5, 14.0, and 17.5%). The relative difference in dietary energy level was used to increase amino acid levels, mineral levels, and the premix inclusion level at the same ratio. Chickens were housed in open-circuit climate respiration chambers from d 0 to 7 after hatch...
March 11, 2017: Poultry Science
https://www.readbyqxmd.com/read/28340220/her2-neu-status-determination-in-breast-cancer-a-single-institutional-experience-using-a-dual-testing-approach-with-immunohistochemistry-and-fluorescence-in-situ-hybridization
#19
James P Solomon, Marie Dell'Aquila, Oluwole Fadare, Farnaz Hasteh
Objectives: According to current guidelines, either immunohistochemistry (IHC) or in situ hybridization (ISH) can be used to determine human epidermal growth factor receptor 2 (Her2/neu) status in breast carcinoma. While the guidelines explicitly delineate result interpretation, there is no consensus on the most appropriate testing algorithm. Methods: The Her2/neu statuses of 369 consecutive cases of invasive breast cancer (from 351 patients) were assessed in a dual-testing algorithm that uses both IHC and fluorescence ISH (FISH)...
March 11, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28340203/been-there-done-that-the-experience-of-acting-as-a-young-adult-mentor-to-adolescents-living-with-chronic-illness
#20
Sara Ahola Kohut, Jennifer Stinson, Paula Forgeron, Stephanie Luca, Lauren Harris
To explore the perceived benefits and challenges of acting as a young adult peer mentor to adolescents with chronic illness.   A qualitative descriptive study, using interviews and a focus group, explored the perceptions of young adult peer mentors following participation in the iPeer2Peer program, a Skype-based peer-mentorship program for adolescents with chronic illness. Interviews and focus group data were transcribed and analyzed using inductive content analysis.   Ten peer mentors (20.00 ± 1...
March 16, 2017: Journal of Pediatric Psychology
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