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https://www.readbyqxmd.com/read/29306724/first-molecular-evidence-of-equine-granulocytic-anaplasmosis-in-pakistan
#1
Sehrish Saleem, Muhammad Ijaz, Shahid Hussain Farooqi, Muhammad Imran Rashid, Amjad Khan, Awais Masud, Amjad Islam Aqib, Kashif Hussain, Khalid Mehmood, Hui Zhang
Anaplasma phagocytophilum (A. phagocytophilum) is an obligate intracellular bacterium that causes equine granulocytic anaplasmosis (EGA) disease in equines. This pathogen has zoonotic potential, which makes it very important to be detected and controlled as early as possible. This study was aimed to assess the molecular prevalence, associated risk factors of EGA along with its effects on various hematological parameters. This study revealed an overall 10.67% prevalence in equine. Horses showed highest prevalence followed by mules and donkeys presenting 11...
January 4, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29297167/health-status-of-pelophylax-ridibundus-amphibia-ranidae-in-a-rice-paddy-ecosystem-in-southern-bulgaria-and-its-importance-in-assessing-environmental-state-haematological-parameters
#2
Zhivko Zhelev, Stefan Tsonev, Katerina Georgieva, Desislava Arnaudova
Pollution effects on haematological parameters in Pelophylax ridibundus individuals were investigated; animals were collected from two sites in Southern Bulgaria: the Tsalapitsa rice fields (RF) and the Vacha river (reference site, RS). Blood analysis showed significant differences between the haematological parameters of RBC, WBC, Hb, packed cell volume (PCV) and frogs' leucogram from RF and those from RS. These findings provide information on long-term background pollution of the habitat (RF) under investigation...
January 3, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29282795/interplay-of-foot-and-mouth-disease-virus-with-cell-mediated-and-humoral-immunity-of-host
#3
REVIEW
Muhammad Abubakar, Shumaila Manzoor, Afshan Ahmed
Foot and mouth disease virus (FMDV) causes a communicable disease of cloven hoofed animals, resulting in major economic losses during disease outbreaks. Like other members of the Picornaviridae FMDV has a relatively short infectious cycle; initiation of infection and dissemination, with production of infectious virions occurs in less than a week. The components of innate immunity as well as cell-mediated and humoral immunity play a crucial role in control of FMDV. However, it has been shown in vitro using a mouse model that FMDV has evolved certain mechanisms to counteract host immune responses ensuring its survival and spread...
December 28, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29260744/-clinical-presentation-of-ixodes-tick-borne-borreliosis-caused-by-borrelia-miyamotoi-in-the-context-of-an-immune-response-to-the-pathogen
#4
A E Platonov, M G Toporkova, N M Kolyasnikova, O A Stukolova, A S Dolgova, A V Brodovikova, N A Makhneva, L S Karan, J Koetsveld, G A Shipulin, V V Maleev
Ixodes tick-borne borreliosis caused by Borrelia miyamotoi (ITBB-BM) is a previously unknown infectious disease discovered in Russia. AIM: The present study continues the investigation of the clinical features of ITBB-BM in the context of an immune system-pathogen interaction. SUBJECTS AND METHODS: The study enrolled 117 patients with ITBB-BM and a comparison group of 71 patients with Lyme disease (LD) that is ITBB with erythema migrans. All the patients were treated at the New Hospital, Yekateringburg...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29242539/atad3a-suppresses-pink1-dependent-mitophagy-to-maintain-homeostasis-of-hematopoietic-progenitor-cells
#5
Guoxiang Jin, Chuan Xu, Xian Zhang, Jie Long, Abdol Hossein Rezaeian, Chunfang Liu, Mark E Furth, Steven Kridel, Boris Pasche, Xiu-Wu Bian, Hui-Kuan Lin
Although deletion of certain autophagy-related genes has been associated with defects in hematopoiesis, it remains unclear whether hyperactivated mitophagy affects the maintenance and differentiation of hematopoietic stem cells (HSCs) and committed progenitor cells. Here we report that targeted deletion of the gene encoding the AAA+-ATPase Atad3a hyperactivated mitophagy in mouse hematopoietic cells. Affected mice showed reduced survival, severely decreased bone-marrow cellularity, erythroid anemia and B cell lymphopenia...
January 2018: Nature Immunology
https://www.readbyqxmd.com/read/29205270/severe-multiple-sclerosis-reactivation-during-prolonged-lymphopenia-after-dimethyl-fumarate-discontinuation
#6
C Zecca, C G Antozzi, V Torri Clerici, M Ferrazzini, R E Mantegazza, S Rossi, C Gobbi
BACKGROUND: Delayed-release dimethyl fumarate (DMF) treatment can be associated with reduced lymphocyte and leucocyte counts, which might persist after DMF discontinuation. CASE PRESENTATION: We report the case of a patient with severe disease reactivation despite prolonged lymphopenia after DMF discontinuation. We describe the frequency and impact of prolonged lymphopenia after DMF discontinuation at two tertiary MS centres. A 36-year-old female patient with multiple sclerosis was switched to DMF after 14 years of treatment with interferon beta-1a...
December 3, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29200144/clinical-challenges-identification-of-patients-with-novel-primary-immunodeficiency-syndromes
#7
David Buchbinder, Mikko Seppanen, V Koneti Rao, Gulbu Uzel, Diane Nugent
Novel primary immunodeficiency disorders are being identified with next generation sequencing technologies. We describe 1 patient with cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) haploinsufficiency who had recurrent enhancing brain lesions, nodular pulmonary infiltrates, hepatosplenomegaly, immune cytopenias, as well as progressive hypogammaglobulinemia and lymphopenia. We describe a second patient with activated p110δ syndrome (APDS)/p110δ activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency (PASLI) in association with recurrent respiratory tract infections, Epstein-Barr virus infection, lymphadenopathy, elevated serum IgM, and progressive lymphopenia...
December 1, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29179171/-aberrant-bone-remodeling-during-sepsis
#8
Asuka Terashima
Sepsis is a systemic inflammatory response syndrome that occurs upon severe bacterial infection. Although the development of early treatment for sepsis improves the survival rate of sepsis patients, in the subacute phase, certain patients suffer from secondary infection due to immunosuppression. It has been reported that one of the causes of the immunocompromised state during sepsis is lymphopenia. However, the underlying mechanisms are not well understood. We found that acute inflammation induced the immunodeficiency caused by the reduction of the numbers of peripheral lymphocytes and common lymphoid progenitors(CLPs)in the bone marrow, which was associated with a dramatic decrease in the osteoblast number...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29178444/alemtuzumab-versus-interferon-beta-1a-for-relapsing-remitting-multiple-sclerosis
#9
REVIEW
Jian Zhang, Shengliang Shi, Yueling Zhang, Jiefeng Luo, Yousheng Xiao, Lian Meng, Xiaobo Yang
BACKGROUND: Alemtuzumab is a humanised monoclonal antibody that alters the circulating lymphocyte pool, causing prolonged lymphopenia, thus remoulding the immune repertoire that accompanies homeostatic lymphocyte reconstitution. It has been proved more effective than interferon (IFN) 1a for the treatment of relapsing-remitting multiple sclerosis (RRMS). OBJECTIVES: To compare the efficacy, tolerability and safety of alemtuzumab versus interferon beta 1a in the treatment of people with RRMS to prevent disease activity...
November 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29167668/a-practical-approach-to-newborn-screening-for-severe-combined-immunodeficiency-using-the-t-cell-receptor-excision-circle-assay
#10
REVIEW
Monica S Thakar, Mary K Hintermeyer, Miranda G Gries, John M Routes, James W Verbsky
Severe combined immunodeficiency (SCID) is a life-threatening condition of newborns and infants caused by defects in genes involved in T cell development. Newborn screening (NBS) for SCID using the T cell receptor excision circle (TREC) assay began in Wisconsin in 2008 and has been adopted or is being implemented by all states in 2017. It has been established that NBS using the TREC assay is extremely sensitive to detect SCID in the newborn period. Some controversies remain regarding how screening positives are handled by individual states, including when to perform confirmatory flow cytometry, what is the necessary diagnostic workup of patients, what infection prophylaxis measures should be taken, and when hematopoietic stem cell transplantation should occur...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29157191/neuronal-vacuolization-in-feline-panleukopenia-virus-infection
#11
Vanessa M Pfankuche, Wendy K Jo, Erhard van der Vries, Nicole Jungwirth, Stephan Lorenzen, Albert D M E Osterhaus, Wolfgang Baumgärtner, Christina Puff
Feline panleukopenia virus (FPV) infections are typically associated with anorexia, vomiting, diarrhea, neutropenia, and lymphopenia. In cases of late prenatal or early neonatal infections, cerebellar hypoplasia is reported in kittens. In addition, single cases of encephalitis are described. FPV replication was recently identified in neurons, although it is mainly found in cells with high mitotic activity. A female cat, 2 months old, was submitted to necropsy after it died with neurologic deficits. Besides typical FPV intestinal tract changes, multifocal, randomly distributed intracytoplasmic vacuoles within neurons of the thoracic spinal cord were found histologically...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/29141790/cerebral-toxoplasmosis-in-an-ms-patient-receiving-fingolimod
#12
Alejandro Enriquez-Marulanda, Jaime Valderrama-Chaparro, Laura Parrado, Juan Diego Vélez, Ana Maria Granados, Jorge Luis Orozco, Jairo Quiñones
Multiple Sclerosis (MS) is an autoimmune disease in which lymphocytes target putative myelin antigens in the CNS, causing inflammation and neurodegeneration. Fingolimod (FTY720) is an immunosuppressive drug used as a second line therapy for relapsing forms of MS due to its safety profile and good response to treatment. Despite its safety, there are still concerns about the possibility of Fingolimod being linked to the development of opportunistic infections like disseminated varicella zoster infections and herpes simplex encephalitis...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29127993/molecular-prevalence-risk-factors-assessment-and-haemato-biochemical-alterations-in-hepatozoonosis-in-dogs-from-punjab-india
#13
Kaushlendra Singh, Harkirat Singh, Nirbhay Kumar Singh, Neeraj Kashyap, Naresh Kumar Sood, Shitanshu Shekar Rath
Hepatozoonosis caused by Hepatozoon canis is an important tick-borne disease of dogs in tropical and sub-tropical regions throughout the world. In the present study evaluation of blood samples collected from 225 dogs presented at Small Animal Clinics, GADVASU, Ludhiana, Punjab (India) was done for the presence of H. canis by PCR based assay targeting a portion of 18S rRNA gene. Of the total samples subjected to PCR, an amplicon of 666bp was detected in 13.78% samples whereas, routine blood smear examination revealed gamonts in 5...
December 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/29066537/how-i-treat-warts-hypogammaglobulinemia-infections-and-myelokathexis-syndrome
#14
REVIEW
Raffaele Badolato, Jean Donadieu
Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a genetic disease characterized by neutropenia, lymphopenia, susceptibility to infections, and myelokathexis, which describes degenerative changes of mature neutrophils and hyperplasia of bone marrow myeloid cells. Some patients present with hypogammaglobulinemia and/or refractory warts of skin and genitalia. Congenital cardiac defects constitute uncommon manifestations of the disease. The disorder, which is inherited as an autosomal dominant trait, is caused by heterozygous mutations of the chemokine receptor CXCR4...
December 7, 2017: Blood
https://www.readbyqxmd.com/read/29065182/clinical-characterization-of-acute-and-convalescent-illness-of-confirmed-chikungunya-cases-from-chiapas-s-mexico-a-cross-sectional-study
#15
Rogelio Danis-Lozano, Esteban Eduardo Díaz-González, Karina Del Carmen Trujillo-Murillo, Sandra Caballero-Sosa, Jesús Sepúlveda-Delgado, Iliana Rosalía Malo-García, Luis Miguel Canseco-Ávila, Luis Manuel Salgado-Corsantes, Sergio Domínguez-Arrevillaga, Raúl Torres-Zapata, Omar Gómez-Cruz, Ildefonso Fernández-Salas
BACKGROUND: The emerging chikungunya virus (CHIKV), is an arbovirus causing intense outbreaks in North America. The situation in Mexico is alarming, and CHIKV threatens to spread further throughout North America. Clinical and biological features of CHIKF outbreaks in Mexico have not been well described; thus, we conducted a cross sectional study of a CHIKV outbreak in Chiapas, Southern Mexico to further characterize these features. METHODOLOGY/PRINCIPAL FINDINGS: We collected blood samples from patients suspected of having chikungunya fever (CHIKF) who presented to Clinical Hospital ISSSTE Dr...
2017: PloS One
https://www.readbyqxmd.com/read/29034989/neurological-presentations-revealing-acquired-copper-deficiency-diagnosis-features-etiologies-and-evolution-in-seven-patients
#16
Aurélia Poujois, Nouzha Djebrani-Oussedik, Fabienne Ory-Magne, France Woimant
BACKGROUND: acquired copper deficiency (ACD) is a rare condition usually diagnosed from haematological changes. AIMS: characterize the diagnosis features and the evolution of patients with ACD revealed by neurological symptoms. METHODS: clinical, biological and MRI data were prospectively analysed at diagnosis and during follow-up under copper supplementation. RESULTS: seven patients were studied over a 5-year period...
October 16, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28931895/defective-thymic-output-in-was-patients-is-associated-with-abnormal-actin-organization
#17
Wenyan Li, Xiaoyu Sun, Jinzhi Wang, Qin Zhao, Rongxin Dai, Yanping Wang, Lina Zhou, Lisa Westerberg, Yuan Ding, Xiaodong Zhao, Chaohong Liu
Wiskott-Aldrich syndrome protein (WASp) is a key regulator of the actin cytoskeleton. Defective T - cell function is a major cause for immune deficiency in Wiskott-Aldrich syndrome (WAS) patients. T cells originate in the bone marrow and develop in the thymus, and then migrate to peripheral tissues. TCR excision circles (TRECs) present in thymic output cells stably, which is used as a molecular marker for thymic output. We found that CD8(+) T naïve cells of classic WAS patients were significantly reduced, and TRECs in patients with classic WAS and X-linked thrombocytopenia (XLT) dramatically decreased compared with that of HCs...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28926774/concurrent-administration-effect-of-antibiotic-and-anti-inflammatory-drugs-on-the-immunotoxicity-of-bacterial-endotoxins
#18
Azza M El Amir, Dalia G Tanious, Hanaa A Mansour
Pseudomonas aeruginosa (P. aeruginosa) is a gram-negative bacterium that causes a variety of diseases in compromised hosts. Bacterial endotoxins such as lipopolysaccharide (LPS) are the major outer surface membrane components that are present in almost all gram-negative bacteria and act as extremely strong stimulators of innate immunity and inflammation of the airway. This study was undertaken to determine the effect of combined administration of Gentamicin (GENT) as an antibiotic and Dexamethasone (DEXA) as an anti-inflammatory drug on some immunological and histological parameters...
November 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28900067/-dimethyl-fumarate-in-multiple-sclerosis
#19
REVIEW
Masami Tanaka, Yuko Shimizu
At the end of 2016, dimethyl fumarate (DMF) was approved as the sixth disease-modifying drug for multiple sclerosis by the Pharmaceuticals and Medical Devices Agency of Japan. Two randomized, placebo-controlled, phase III studies (DEFINE and CONFIRM) showed beneficial effects in patients in Western countries, with relapsing-remitting multiple sclerosis (RRMS). Some of the benefits included a decreased annual relapse rate, inhibition of disease activity (shown using brain magnetic resonance imaging), and a decreased proportion of patients with confirmed disease progression...
September 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28881832/the-novel-sphingosine-1-phosphate-receptors-antagonist-ad2900-affects-lymphocyte-activation-and-inhibits-t-cell-entry-into-the-lymph-nodes
#20
Jing Song, Arie Dagan, Zhanna Yakhtin, Shimon Gatt, Sean Riley, Hugh Rosen, Reuven Or, Osnat Almogi-Hazan
Sphingolipid derivatives play key roles in immune cell migration and function. Synthetic sphingolipid analogues are used as therapeutics to intervene various inflammatory and malignant conditions. We hypothesize that different analogs have different effects on immune cells and therefore can be used as treatment for specific diseases. This study examines the properties of the novel synthetic sphingolipid analog, AD2900, and its effects on immune cell activation and lymphocyte localization in homeostasis. AD2900 is an antagonist for all sphingosine-1-phosphate (S1P) receptors...
August 8, 2017: Oncotarget
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