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https://www.readbyqxmd.com/read/27858202/computational-drill-down-on-fgf1-heparin-interactions-through-methodological-evaluation
#1
Sándor Babik, Sergey A Samsonov, M Teresa Pisabarro
Glycosaminoglycans (GAGs) exhibit a key role in cellular communication processes through interactions with target proteins of the extracellular matrix (ECM). The sandwich-like interaction established between Fibroblast growth factor (FGF) and heparin (HE) represents quite a peculiar protein-GAG-protein system, which has been both structurally and functionally intensively studied. The molecular recognition characteristics of this system have been exploited in various computational studies in order to deepen understanding of GAG-protein interactions...
November 17, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27818937/depot-specific-differences-in-angiogenic-capacity-of-adipose-tissue-in-differential-susceptibility-to-diet-induced-obesity
#2
Mun-Gyu Song, Hye-Jin Lee, Bo-Yeong Jin, Ruth Gutierrez-Aguilar, Kyung-Ho Shin, Sang-Hyun Choi, Sung Hee Um, Dong-Hoon Kim
OBJECTIVE: Adipose tissue (AT) expansion requires AT remodeling, which depends on AT angiogenesis. Modulation of AT angiogenesis could have therapeutic promise for the treatment of obesity. However, it is unclear how the capacity of angiogenesis in each adipose depot is affected by over-nutrition. Therefore, we investigated the angiogenic capacity (AC) of subcutaneous and visceral fats in lean and obese mice. METHODS: We compared the AC of epididymal fat (EF) and inguinal fat (IF) using an angiogenesis assay in diet-induced obese (DIO) mice and diet-resistant (DR) mice fed a high-fat diet (HFD)...
November 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27805868/ovariectomy-alters-gene-expression-of-the-hippocampal-formation-in-middle-aged-rats
#3
Miklós Sárvári, Imre Kalló, Erik Hrabovszky, Norbert Solymosi, Zsolt Liposits
Ovarian hormones regulate the transcriptome of the hippocampus and modulate its functions. During menopause this complex signaling declines, leading to impaired learning and memory. This study was undertaken to clarify the effects of long-term, surgical ovariectomy (OVX) on the rat hippocampal transcriptome. At age of 13 months, intact control and ovariectomized groups were formed. All animals were sacrificed 5 weeks after gonadectomy, hippocampal formations were dissected and processed for transcriptome analysis...
November 2, 2016: Endocrinology
https://www.readbyqxmd.com/read/27677452/comparative-expression-and-regulation-of-duplicated-fibroblast-growth-factor-1-genes-in-grass-carp-ctenopharyngodon-idella
#4
Dan-Dan Guo, Wen-Zhi Guan, Yi-Wen Sun, Jie Chen, Xia-Yun Jiang, Shu-Ming Zou
Fibroblast growth factor 1 (Fgf1) is known as a mitogenic factor involved in the regulation of cell growth, proliferation, and differentiation in vertebrates. Here, we report the isolation and characterization of two fgf1 genes in grass carp (Ctenopharyngodon idella). Grass carp fgf1a and fgf1b cDNAs are highly divergent, sharing a relatively low amino acid sequence identity of 50%, probably due to fish-specific gene duplication. fgf1a and fgf1b mRNAs were detected in the zygote and expressed throughout embryogenesis...
January 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27663888/proteomic-study-of-hepatocellular-carcinoma-using-a-novel-modified-aptamer-based-array-somascan%C3%A2-platform
#5
Zhiwei Qiao, Xiaoqing Pan, Cuneyd Parlayan, Hidenori Ojima, Tadashi Kondo
Vascular invasion is a pathological hallmark of hepatocellular carcinoma (HCC), associated with poor prognosis; it is strongly related to the early recurrence and poor survival after curative resection. In order to determine the proteomic backgrounds of HCC carcinogenesis and vascular invasion, we employed a novel modified aptamer-based array (SOMAscan) platform. SOMAscan is based on the Slow Off-rate Modified Aptamers (SOMAmers), which rely on the natural 3D folding of single-stranded DNA-based protein affinity reagents...
September 20, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27663556/gas-phase-analysis-of-the-complex-of-fibroblast-growthfactor-1-with-heparan-sulfate-a-traveling-wave-ion-mobility-spectrometry-twims-and-molecular-modeling-study
#6
Yuejie Zhao, Arunima Singh, Yongmei Xu, Chengli Zong, Fuming Zhang, Geert-Jan Boons, Jian Liu, Robert J Linhardt, Robert J Woods, I Jonathan Amster
Fibroblast growth factors (FGFs) regulate several cellular developmental processes by interacting with cell surface heparan proteoglycans and transmembrane cell surface receptors (FGFR). The interaction of FGF with heparan sulfate (HS) is known to induce protein oligomerization, increase the affinity of FGF towards its receptor FGFR, promoting the formation of the HS-FGF-FGFR signaling complex. Although the role of HS in the signaling pathways is well recognized, the details of FGF oligomerization and formation of the ternary signaling complex are still not clear, with several conflicting models proposed in literature...
September 23, 2016: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/27663377/expression-and-localization-of-fibroblast-growth-factor-fgf-family-in-buffalo-ovarian-follicle-during-different-stages-of-development-and-modulatory-role-of-fgf2-on-steroidogenesis-and-survival-of-cultured-buffalo-granulosa-cells
#7
S R Mishra, N Thakur, A Somal, M S Parmar, R Reshma, G Rajesh, V P Yadav, M K Bharti, Jaya Bharati, A Paul, V S Chouhan, G T Sharma, G Singh, M Sarkar
The present study investigated the expression and localization of FGF and its functional receptors in the follicle of buffalo and the treatment of FGF2 on mRNA expression of CYP19A1 (aromatase), PCNA, and BAX (BCL-2 associated X protein) in cultured buffalo granulosa cells (GCs). Follicles were classified into four groups based on size and E2 level in follicular fluid (FF): F1, 4-6mm diameter, E2<0.5ng/ml of FF; F2, 7-9mm, E2=0.5-5ng/ml; F3, 10-13mm, E2=5-40ng/ml; F4, >14mm, E2>180ng/ml. The qPCR studies revealed that the mRNA expression of FGF1, FGF2 and FGF7 were maximum (P<0...
October 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27638903/activation-of-heat-shock-response-augments-fibroblast-growth-factor-1-expression-in-wounded-lung-epithelium
#8
Rachel G Scheraga, Christopher Thompson, Mohan E Tulapurkar, Ashish C Nagarsekar, Mark Cowan, Ratnakar Potla, Junfeng Sun, Rongman Cai, Carolea Logun, James Shelhamer, Nevins W Todd, Ishwar S Singh, Irina G Luzina, Sergei P Atamas, Jeffrey D Hasday
We previously showed that coincident exposure to heat shock (HS; 42°C for 2 h) and TNF-α synergistically induces apoptosis in mouse lung epithelium. We extended this work by analyzing HS effects on human lung epithelial responses to clinically relevant injury. Cotreatment with TNF-α and HS induced little caspase-3 and poly(ADP-ribose) polymerase cleavage in human small airway epithelial cells, A549 cells, and BEAS2B cells. Scratch wound closure rates almost doubled when A549 and BEAS2B cells and air-liquid interface cultures of human bronchial epithelial cells were heat shocked immediately after wounding...
November 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27625023/hif-1%C3%AE-in-myeloid-cells-promotes-adipose-tissue-remodeling-toward-insulin-resistance
#9
Akiko Takikawa, Arshad Mahmood, Allah Nawaz, Tomonobu Kado, Keisuke Okabe, Seiji Yamamoto, Aminuddin Aminuddin, Satoko Senda, Koichi Tsuneyama, Masashi Ikutani, Yasuharu Watanabe, Yoshiko Igarashi, Yoshinori Nagai, Kiyoshi Takatsu, Keiichi Koizumi, Johji Imura, Nobuhito Goda, Masakiyo Sasahara, Michihiro Matsumoto, Kumiko Saeki, Takashi Nakagawa, Shiho Fujisaka, Isao Usui, Kazuyuki Tobe
Adipose tissue hypoxia is an important feature of pathological adipose tissue expansion. Hypoxia-inducible factor-1α (HIF-1α) in adipocytes reportedly induces oxidative stress and fibrosis, rather than neoangiogenesis via vascular endothelial growth factor (VEGF)-A. We previously reported that macrophages in crown-like structures (CLSs) are both hypoxic and inflammatory. In the current study, we examined how macrophage HIF-1α is involved in high-fat diet (HFD)-induced inflammation, neovascularization, hypoxia, and insulin resistance using mice with myeloid cell-specific HIF-1α deletion that were fed an HFD...
December 2016: Diabetes
https://www.readbyqxmd.com/read/27615514/proximity-labeling-reveals-molecular-determinants-of-fgfr4-endosomal-transport
#10
Ellen Margrethe Haugsten, Vigdis Sørensen, Michaela Kunova Bosakova, Gustavo Antonio de Souza, Pavel Krejci, Antoni Wiedlocha, Jørgen Wesche
The fibroblast growth factor receptors (FGFRs) are important oncogenes promoting tumor progression in many types of cancer, such as breast, bladder, and lung cancer as well as multiple myeloma and rhabdomyosarcoma. However, little is known about how these receptors are internalized and down-regulated in cells. We have here applied proximity biotin labeling to identify proteins involved in FGFR4 signaling and trafficking. For this purpose we fused a mutated biotin ligase, BirA*, to the C-terminal tail of FGFR4 (FGFR4-BirA*) and the fusion protein was stably expressed in U2OS cells...
October 7, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27600422/-regulation-of-airway-stem-cell-proliferation-in-idiopathic-pulmonary-fibrosis
#11
S X Yang, Q Wu, X Sun, X Li, K Li, L Xu, Y Li, Q Y Zhang, Y C Zhang, H Y Chen
OBJECTIVE: To investigate the effect of fibroblasts on regulating airway stem cell proliferation in idiopathic pulmonary fibrosis. METHODS: Lung cell suspension was prepared from β-actin-GFP mice. Airway stem cells were obtained by fluorescence activated cell sorting and co-cultured with lung fibroblasts. The fibroblasts were treated with TGF-β inhibitor SB43142. The expression of growth factors FGF1/2 and the effect of FGF1/2 on stem cell proliferation were observed...
September 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27507643/promoting-differentiation-of-cultured-myoblasts-using-biomimetic-surfaces-that-present-alpha-laminin-2-peptides
#12
Francine Parker, Kathryn White, Siȏn Phillips, Michelle Peckham
Traditionally, muscle cell lines are cultured on glass coverslips and differentiated to investigate myoblast fusion and differentiation. Efficient differentiation of myoblasts produces a dense network of myotubes with the correct organisation for contraction. Here we have tested the ability of artificially generated, precisely controlled peptide surfaces to enhance the efficiency of myoblast differentiation. We focused on specific short peptides from α-laminin-2 (IKVSV, VQLRNGFPYFSY and GLLFYMARINHA) as well as residues 15-155 from FGF1...
October 2016: Cytotechnology
https://www.readbyqxmd.com/read/27443835/fibroblast-growth-factor-rescues-brain-endothelial-cells-lacking-presenilin-1-from-apoptotic-cell-death-following-serum-starvation
#13
Miguel A Gama Sosa, Rita De Gasperi, Patrick R Hof, Gregory A Elder
Presenilin 1 (Psen1) is important for vascular brain development and is known to influence cellular stress responses. To understand the role of Psen1 in endothelial stress responses, we investigated the effects of serum withdrawal on wild type (wt) and Psen1-/- embryonic brain endothelial cells. Serum starvation induced apoptosis in Psen1-/- cells but did not affect wt cells. PI3K/AKT signaling was reduced in serum-starved Psen1-/- cells, and this was associated with elevated levels of phospho-p38 consistent with decreased pro-survival AKT signaling in the absence of Psen1...
July 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27443518/characterization-of-fn1-fgfr1-and-novel-fn1-fgf1-fusion-genes-in-a-large-series-of-phosphaturic-mesenchymal-tumors
#14
Jen-Chieh Lee, Sheng-Yao Su, Chun A Changou, Rong-Sen Yang, Keh-Sung Tsai, Michael T Collins, Eric S Orwoll, Chung-Yen Lin, Shu-Hwa Chen, Shyang-Rong Shih, Cheng-Han Lee, Yoshinao Oda, Steven D Billings, Chien-Feng Li, G Petur Nielsen, Eiichi Konishi, Fredrik Petersson, Thomas O Carpenter, Kesavan Sittampalam, Hsuan-Ying Huang, Andrew L Folpe
Phosphaturic mesenchymal tumors typically cause paraneoplastic osteomalacia, chiefly as a result of FGF23 secretion. In a prior study, we identified FN1-FGFR1 fusion in 9 of 15 phosphaturic mesenchymal tumors. In this study, a total of 66 phosphaturic mesenchymal tumors and 7 tumors resembling phosphaturic mesenchymal tumor but without known phosphaturia were studied. A novel FN1-FGF1 fusion gene was identified in two cases without FN1-FGFR1 fusion by RNA sequencing and cross-validated with direct sequencing and western blot...
July 22, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27412358/fibroblast-growth-factors-new-insights-new-targets-in-the-management-of-diabetes
#15
Ioannis Kyrou, Martin O Weickert, Seley Gharanei, Harpal S Randeva, Bee K Tan
The fibroblast growth factor (FGF) family consists of 22 evolutionarily and structurally related proteins (FGF1 to FGF23; with FGF15 being the rodent ortholog of human FGF19). Based on their mechanism of action, FGFs can be categorized into intracrine, autocrine/paracrine and endocrine subgroups. Both autocrine/paracrine and endocrine FGFs are secreted from their cells of origin and exert their effects on target cells by binding to and activating specific single-pass transmembrane tyrosine kinase receptors (FGFRs)...
July 14, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27387234/suramin-blocks-interaction-between-human-fgf1-and-fgfr2-d2-domain-and-reduces-downstream-signaling-activity
#16
Zong-Sian Wu, Che Fu Liu, Brian Fu, Ruey-Hwang Chou, Chin Yu
The extracellular portion of the human fibroblast growth factor receptor2 D2 domain (FGFR2 D2) interacts with human fibroblast growth factor 1 (hFGF1) to activate a downstream signaling cascade that ultimately affects mitosis and differentiation. Suramin is an antiparasiticdrug and a potent inhibitor of FGF-induced angiogenesis. Suramin has been shown to bind to hFGF1, and might block the interaction between hFGF1 and FGFR2 D2. Here, we titrated hFGF1 with FGFR2 D2 and suramin to elucidate their interactions using the detection of NMR...
September 2, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27353029/notch-signaling-activation-is-associated-with-patient-mortality-and-increased-fgf1-mediated-invasion-in-squamous-cell-carcinoma-of-the-oral-cavity
#17
Alice N Weaver, M Benjamin Burch, Tiffiny S Cooper, Deborah L Della Manna, Shi Wei, Akinyemi I Ojesina, Eben L Rosenthal, Eddy S Yang
UNLABELLED: Oral squamous cell carcinoma (OSCC) is a cancer subtype that lacks validated prognostic and therapeutic biomarkers, and human papillomavirus status has not proven beneficial in predicting patient outcomes. A gene expression pathway analysis was conducted using OSCC patient specimens to identify molecular targets that may improve management of this disease. RNA was isolated from 19 OSCCs treated surgically at the University of Alabama at Birmingham (UAB; Birmingham, AL) and evaluated using the NanoString nCounter system...
September 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27324104/fgf1-and-fgf2-mutations-in-preeclampsia-and-related-features
#18
Ben Ali Gannoun Marwa, Nozha Raguema, Hedia Zitouni, Hachani Ben Ali Feten, Kacem Olfa, Raja Elfeleh, Wassim Almawi, Touhami Mahjoub
BACKGROUND: Fibroblast growth factor (FGF) 1 and FGF2 were previously linked with preeclampsia (PE), possibly through altering decidual and placental FGFR2 expression. Since common variation in FGF1 and FGF2 might influence FGF1 and FGF2 activity, this study evaluated whether common FGF1 and FGF2 variants are linked with PE and associated features. METHODS: The association between FGF1 rs34011 and FGF2 rs2922979 SNPs and PE were tested in 300 women with PE, and 300 age-matched control women...
July 2016: Placenta
https://www.readbyqxmd.com/read/27312726/metabolic-disease-fgf1-stops-diabetes-in-its-tracks
#19
Sarah Crunkhorn
No abstract text is available yet for this article.
July 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27305863/canonical-fgfs-prevent-osteogenic-lineage-commitment-and-differentiation-of-human-bone-marrow-stromal-cells-via-erk1-2-signaling
#20
Meike Simann, Solange Le Blanc, Verena Schneider, Viola Zehe, Martin Lüdemann, Norbert Schütze, Franz Jakob, Tatjana Schilling
Controlling the adipo-osteogenic lineage decision of trabecular human bone marrow stromal cells (hBMSCs) in favor of osteogenesis represents a promising approach for osteoporosis therapy and prevention. Previously, Fibroblast Growth Factor 1 (FGF1) and its subfamily member FGF2 were scored as leading candidates to exercise control over skeletal precursor commitment and lineage decision albeit literature results are highly inconsistent. We show here that FGF1 and 2 strongly prevent the osteogenic commitment and differentiation of hBMSCs...
June 16, 2016: Journal of Cellular Biochemistry
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