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State of the art cardiology

Eric R Bates, Jacqueline E Tamis-Holland, John A Bittl, Patrick T O'Gara, Glenn N Levine
Recent randomized controlled trials have suggested that patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease may benefit more from multivessel percutaneous coronary intervention (PCI) compared with culprit vessel-only primary PCI. The American College of Cardiology, American Heart Association, and Society for Cardiovascular Angiography and Interventions recently published an updated recommendation on this topic. The purpose of this State-of-the-Art Review is to accurately document existing published reports, describe their limitations, and establish a base for future studies...
September 6, 2016: Journal of the American College of Cardiology
Attila Ambrus, Junjie Wang, Reka Mizsei, Zsofia Zambo, Beata Torocsik, Frank Jordan, Vera Adam-Vizi
Pathogenic amino acid substitutions of the common E3 component (hE3) of the human alpha-ketoglutarate dehydrogenase and the pyruvate dehydrogenase complexes lead to severe metabolic diseases (E3 deficiency), which usually manifest themselves in cardiological and/or neurological symptoms and often cause premature death. To date, 14 disease-causing amino acid substitutions of the hE3 component have been reported in the clinical literature. None of the pathogenic protein variants has lent itself to high-resolution structure elucidation by X-ray or NMR...
August 17, 2016: Biochimica et Biophysica Acta
P K Wilson, B A Franklin
In brief: Cardiac rehabilitation, born of cardiology in order to care for patients with coronary heart disease, has evolved into an accepted area of clinical practice. As more and more patients survive a coronary event, the need for state-of-the-art methods of rehabilitation will be increasingly needed. The author reviews the history of cardiac rehabilitation, discusses its current status, and predicts What courses of action will be needed as the field continues to evolve.
September 1988: Physician and Sportsmedicine
Sadeer G Al-Kindi, Chantal ElAmm, Mahazarin Ginwalla, Emile Mehanna, Michael Zacharias, Rodolfo Benatti, Guilherme H Oliveira, Chris T Longenecker
BACKGROUND: Persons living with HIV are at a higher risk of cardiovascular disease despite effective antiretroviral therapy and dramatic reductions in AIDS-related conditions. We sought to identify the epidemiology of heart failure (HF) among persons living with HIV in the United States in an era of contemporary antiretroviral therapy. METHODS: Explorys is an electronic healthcare database that aggregates medical records from 23 healthcare systems nationwide. Using systemized nomenclature of medicine-clinical terms (SNOMED-CT), we identified adult patients (age>18), who had active records over the past year (September 2014-September 2015)...
September 1, 2016: International Journal of Cardiology
Pablo López-García, Markus Kreuzthaler, Stefan Schulz, Daniel Scherr, Philipp Daumke, Kornél Markó, Jan A Kors, Erik M van Mulligen, Xinkai Wang, Hanney Gonna, Elijah Behr, Ángel Honrado
The vast amount of clinical data in electronic health records constitutes a great potential for secondary use. However, most of this content consists of unstructured or semi-structured texts, which is difficult to process. Several challenges are still pending: medical language idiosyncrasies in different natural languages, and the large variety of medical terminology systems. In this paper we present SEMCARE, a European initiative designed to minimize these problems by providing a multi-lingual platform (English, German, and Dutch) that allows users to express complex queries and obtain relevant search results from clinical texts...
2016: Studies in Health Technology and Informatics
Anthony C Dona, Sean Coffey, Gemma Figtree
Numerous molecular screening strategies have recently been developed to measure the chemical diversity of a population's biofluids with the ultimate aim to provide clinicians, medical scientists and epidemiologists with a clearer picture of the presence and severity of cardiovascular disease; prognosis; and response to treatment. Current cardiology practice integrates clinical history and examination with state-of-the-art imaging, invasive measures, and electrical interrogation. Biomarkers in common clinical use are relatively limited to troponin and brain natriuretic peptide, dependent on damage to heart muscle, or myocyte 'stretch' respectively...
October 2016: European Journal of Preventive Cardiology
Giuseppe Giacchi, Luis Ortega-Paz, Salvatore Brugaletta, Kohki Ishida, Marco Hernandez-Enriquez, Gustavo Jimenez-Britez, Manel SABATè
Coronary bioresorbable vascular scaffolds (BVS) are a new appealing therapeutic option in interventional cardiology. To date, the Absorb BVS™ (Abbott Vascular, Santa Clara, CA, USA) is the most used and studied device. Its backbone is made of poly-L-lactide and coated by a thin layer of poly-D,L-lactide; everolimus is released and the scaffold is fully degraded to H2O and CO2 in 2-3 years. The BVS technology seems to offer several theoretical advantages over metallic stent implantation. It gives temporary mechanical support to vessel wall, without permanently caging it...
June 2016: Panminerva Medica
Wanda Acampa, Ronny R Buechel, Alessia Gimelli
The use of myocardial perfusion imaging has seen a tremendous growth during the last decade and has become the most commonly used non-invasive imaging tool for risk stratification in patients with suspected and known coronary artery disease. Adherence to radiation safety best practices varied significantly between laboratories but the possibility to use the new cameras in nuclear cardiology can reduce dramatically the radiation dose without losing accuracy. Moreover, the physical characteristics of ultrafast technology could be able to open new doors for the evaluation of old parameters, changing the impact of nuclear cardiology in the diagnostic strategies...
June 2016: European Heart Journal Cardiovascular Imaging
Erik B Schelbert, Daniel R Messroghli
While cardiovascular magnetic resonance (MR) has become the noninvasive tool of choice for the assessment of myocardial viability and for the detection of acute myocardial edema, cardiac T1 mapping is believed to further extend the ability of cardiovascular MR to characterize the myocardium. Fundamentally, cardiovascular MR can improve diagnosis of disease that historically has been challenging to establish with other imaging modalities. For example, decreased native T1 values appear highly specific to detect and quantify disease severity related to myocardial iron overload states or glycosphingolipid accumulation in Anderson-Fabry disease, whereas high native T1 values are observed with edema, amyloid, and other conditions...
March 2016: Radiology
Peng Peng, Karim Lekadir, Ali Gooya, Ling Shao, Steffen E Petersen, Alejandro F Frangi
Cardiovascular magnetic resonance (CMR) has become a key imaging modality in clinical cardiology practice due to its unique capabilities for non-invasive imaging of the cardiac chambers and great vessels. A wide range of CMR sequences have been developed to assess various aspects of cardiac structure and function, and significant advances have also been made in terms of imaging quality and acquisition times. A lot of research has been dedicated to the development of global and regional quantitative CMR indices that help the distinction between health and pathology...
April 2016: Magma
Sara Seitun, Margherita Castiglione Morelli, Irilda Budaj, Sara Boccalini, Athena Galletto Pregliasco, Alberto Valbusa, Filippo Cademartiri, Carlo Ferro
Since its introduction about 15 years ago, coronary computed tomography angiography has become today the most accurate clinical instrument for noninvasive assessment of coronary atherosclerosis. Important technical developments have led to a continuous stream of new clinical applications together with a significant reduction in radiation dose exposure. Latest generation computed tomography scanners (≥ 64 slices) allow the possibility of performing static or dynamic perfusion imaging during stress by using coronary vasodilator agents (adenosine, dipyridamole, or regadenoson), combining both functional and anatomical information in the same examination...
February 2016: Revista Española de Cardiología
M Ministeri, R Alonso-Gonzalez, L Swan, K Dimopoulos
Advances in cardiology and cardiac surgery have transformed the outlook for patients with congenital heart disease (CHD) so that currently 85% of neonates with CHD survive into adult life. Although early surgery has transformed the outcome of these patients, it has not been curative. Heart failure, endocarditis, arrhythmias and pulmonary hypertension are the most common long term complications of adults with CHD. Adults with CHD benefit from tertiary expert care and early recognition of long-term complications and timely management are essential...
2016: Expert Review of Cardiovascular Therapy
Manish Motwani, Daniel S Berman, Guido Germano, Piotr Slomka
Quantitative analysis of SPECT and PET has become a major part of nuclear cardiology practice. Current software tools can automatically segment the left ventricle, quantify function, establish myocardial perfusion maps, and estimate global and local measures of stress/rest perfusion, all with minimal user input. State-of-the-art automated techniques have been shown to offer high diagnostic accuracy for detecting coronary artery disease, as well as predict prognostic outcomes. This article briefly reviews these techniques, highlights several challenges, and discusses the latest developments...
February 2016: Cardiology Clinics
Maria Lucia Specchia, Chiara Cadeddu, Emanuela Lovato, Silvio Capizzi, Anna Maria Ferriero, Marina Veneziano, Agostino Mancuso, Walter Ricciardi
INTRODUCTION: Medical malpractice and litigation have a significant impact on the Italian National Health Service. The aim of this study was to analyze the state of the art of medical errors in Italy, in particular, assessing which specialties are most affected. METHODS: We performed a literature search in PubMed, Google Scholar; institutional websites (Ministry of Health, Higher Institute of Health, National Agency for Regional Health Services, National Institute of Statistics, National Research Council, Court of Auditors), gray literature and specialized magazines...
July 2015: Igiene e Sanità Pubblica
Ahmadreza Baghaie, Zeyun Yu, Roshan M D'Souza
Optical coherence tomography (OCT) is an emerging imaging modality that has been widely used in the field of biomedical imaging. In the recent past, it has found uses as a diagnostic tool in dermatology, cardiology, and ophthalmology. In this paper we focus on its applications in the field of ophthalmology and retinal imaging. OCT is able to non-invasively produce cross-sectional volumetric images of the tissues which can be used for analysis of tissue structure and properties. Due to the underlying physics, OCT images suffer from a granular pattern, called speckle noise, which restricts the process of interpretation...
August 2015: Quantitative Imaging in Medicine and Surgery
Thomas Alexander, Ajit S Mullasari, Zuzana Kaifoszova, Umesh N Khot, Brahmajee Nallamothu, Rao G V Ramana, Meenakshi Sharma, Kala Subramaniam, Ganesh Veerasekar, Suma M Victor, Kiran Chand, P K Deb, K Venugopal, H K Chopra, Santanu Guha, Amal Kumar Banerjee, A Muruganathan Armugam, Manotosh Panja, Gurpreet Singh Wander
The health care burden of ST elevation myocardial infarction (STEMI) in India is enormous. Yet, many patients with STEMI can seldom avail timely and evidence based reperfusion treatments. This gap in care is a result of financial barriers, limited healthcare infrastructure, poor knowledge and accessibility of acute medical services for a majority of the population. Addressing some of these issues, STEMI India, a not-for-profit organization, Cardiological Society of India (CSI) and Association Physicians of India (API) have developed a protocol of "systems of care" for efficient management of STEMI, with integrated networks of facilities...
September 2015: Indian Heart Journal
Jeffrey P Jacobs
In the United States of America alone, ~14,000 children are hospitalised annually with acute heart failure. The science and art of caring for these patients continues to evolve. The International Pediatric Heart Failure Summit of Johns Hopkins All Children's Heart Institute was held on 4 and 5 February, 2015. The 2015 International Pediatric Heart Failure Summit of Johns Hopkins All Children's Heart Institute was funded through the Andrews/Daicoff Cardiovascular Program Endowment, a philanthropic collaboration between All Children's Hospital and the Morsani College of Medicine at the University of South Florida (USF)...
August 2015: Cardiology in the Young
Sanjeeb Roy, Jugal Sharma
Chronic total occlusion (CTO) is considered as the most challenging frontier in interventional cardiology and the last one to be conquered. With availability of state of art hardware, wires and catheters in particular and increased skills of the operators, the success rate for recanalization of CTO by percutaneous catheter intervention (PCI) has improved. Yet the complications rate and long-term adverse events are high, mostly due to failure in tracking or navigation of hardware through the occluded CTO segment, prolonged exposure to radiation and high doses of contrast used...
September 8, 2015: Current Cardiology Reviews
Elham Kayvanpour, Tommaso Mansi, Farbod Sedaghat-Hamedani, Ali Amr, Dominik Neumann, Bogdan Georgescu, Philipp Seegerer, Ali Kamen, Jan Haas, Karen S Frese, Maria Irawati, Emil Wirsz, Vanessa King, Sebastian Buss, Derliz Mereles, Edgar Zitron, Andreas Keller, Hugo A Katus, Dorin Comaniciu, Benjamin Meder
BACKGROUND: Despite modern pharmacotherapy and advanced implantable cardiac devices, overall prognosis and quality of life of HF patients remain poor. This is in part due to insufficient patient stratification and lack of individualized therapy planning, resulting in less effective treatments and a significant number of non-responders. METHODS AND RESULTS: State-of-the-art clinical phenotyping was acquired, including magnetic resonance imaging (MRI) and biomarker assessment...
2015: PloS One
Seiji Hokimoto, Satoshi Yasuda, Daisuke Sueta, Kenichi Tsujita, Kenji Sakamoto, Megumi Yamamuro, Yasuhiro Izumiya, Yuichiro Arima, Hiroki Usuku, Yoko Sumida, Sunao Kojima, Koichi Kaikita, Hisanori Kanazawa, Hiroshige Yamabe, Hisao Ogawa
The 79th Annual Scientific Meeting of the Japanese Circulation Society was held in Osaka on April 24-26, 2015. The main theme was "Late-breaking Cardiovascular Medicine from Japan". Recently, optimal medical treatment has been guided by evidence-based medicine. We aim to emphasize the research findings and advances in cardiology from Japan, in the hope that Japan will become one of the leaders in the field worldwide. Unlike previous meetings, this annual scientific meeting was held in late April. Approximately 18,000 people, including medical doctors, healthcare professionals, and management staff, attended...
2015: Circulation Journal: Official Journal of the Japanese Circulation Society
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