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https://www.readbyqxmd.com/read/28432997/serum-uric-acid-level-is-linked-to-the-disease-progression-rate-in-male-patients-with-multiple-system-atrophy
#1
Jiro Fukae, Shinsuke Fujioka, Shosaburo Yanamoto, Akio Mori, Takahiro Nomi, Taku Hatano, Kousuke Fukuhara, Shinji Ouma, Nobutaka Hattori, Yoshio Tsuboi
OBJECTIVES: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder that may be caused in part by oxidative stress. Uric acid (UA) protects neurons in neurodegenerative disorders via antioxidative effects. The aim of this study was to investigate the relationship between the serum UA concentration and disease progression in MSA patients. PATIENTS AND METHODS: A total of 53 Japanese MSA patients were enrolled in this study. The disease progression rate was estimated by the rate of global disability scale change per year...
April 3, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28432995/eye-disorder-differentiates-seasonality-outcomes-in-persons-with-severe-visual-impairment
#2
Heller Madsen, Henrik Dam, Ida Hageman
BACKGROUND: Light plays a crucial role in both the pathogenesis and treatment of seasonal affective disorder (SAD). Consequently decreased retinal sensitivity to light has been suggested to be a risk factor for SAD. In a population of persons with severe visual impairment we recently found a highly increased prevalence of SAD. We now aimed to identify eye disorders or anatomical locations with specific association to seasonality. METHODS: In 912 cases (33%) from our prior seasonal pattern assessment questionnaire (SPAQ) screening study, we retrieved eye diagnoses from the Danish National Patient Registry and analyzed for specific eye disorders or anatomical locations that significantly differentiated SPAQ outcomes (global seasonality score, (GSS) and SPAQ-SAD prevalence)...
April 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28432965/spatiotemporal-description-of-btex-volatile-organic-compounds-in-a-middle-eastern-megacity-tehran-study-of-exposure-prediction-for-environmental-health-research-tehran-sepehr
#3
Heresh Amini, Vahid Hosseini, Christian Schindler, Hossein Hassankhany, Masud Yunesian, Sarah B Henderson, Nino Künzli
The spatiotemporal variability of ambient volatile organic compounds (VOCs) in Tehran, Iran, is not well understood. Here we present the design, methods, and results of the Tehran Study of Exposure Prediction for Environmental Health Research (Tehran SEPEHR) on ambient concentrations of benzene, toluene, ethylbenzene, p-xylene, m-xylene, o-xylene (BTEX), and total BTEX. To date, this is the largest study of its kind in a low- and middle-income country and one of the largest globally. We measured BTEX concentrations at five reference sites and 174 distributed sites identified by a cluster analytic method...
April 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28432864/plutonium-in-the-atmosphere-a-global-perspective
#4
REVIEW
P Thakur, H Khaing, S Salminen-Paatero
A number of potential source terms have contributed plutonium isotopes to the atmosphere. The atmospheric nuclear weapon tests conducted between 1945 and 1980 and the re-entry of the burned SNAP-9A satellite in 1964, respectively. It is generally believed that current levels of plutonium in the stratosphere are negligible and compared with the levels generally found at surface-level air. In this study, the time trend analysis and long-term behavior of plutonium isotopes ((239+240)Pu and (238)Pu) in the atmosphere were assessed using historical data collected by various national and international monitoring networks since 1960s...
April 19, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28432859/the-impact-of-global-climate-change-on-the-spread-of-parasitic-nematodes
#5
Anna Okulewicz
Climate changes may influence the frequency, intensity and geographical distribution of parasites, directly affecting their dispersive stages in the environment (eggs, larvae) and, indirectly, the larvae living mainly in invertebrate intermediate hosts. In biologically diverse nematodes climate warming contributes to the increase in the range of distribution, colonization of new hosts and modification of their development cycles. This is particularly acute in the Arctic and pertains, for instance, to nematodes Ostertagia gruehneri and Setaria tundra parasitizing reindeer Rangifer tarandus and Umingmakstrongylus pallikuukensis in musk oxen (Ovibos moschatus)...
2017: Annals of Parasitology
https://www.readbyqxmd.com/read/28432811/yu-et%C3%A2-al-host-cell-mutants-resistant-to-cryptosporidium-parvum-characterization-of-host-cell-mutants-significantly-resistant-to-cryptosporidium-parvum-infection
#6
Xue Yu, Haili Zhang, Guan Zhu
Cryptosporidium parvum is a parasitic protist and a causative agent of mild to severe diarrheal diseases in humans and animals. Despite its globally recognized importance, knowledge on the mechanism of parasite invasion and molecular interactions between host cells and the parasite is limited. Here we report the establishment of 43 mutant cell lines derived from HCT-8 cells by UV-induced mutagenesis and the characterization of three mutants with significantly reduced susceptibility to cryptosporidial infection...
April 22, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/28432773/transition-of-the-functional-brain-network-related-to-increasing-cognitive-demands
#7
Karolina Finc, Kamil Bonna, Monika Lewandowska, Tomasz Wolak, Jan Nikadon, Joanna Dreszer, Włodzisław Duch, Simone Kühn
Network neuroscience provides tools that can easily be used to verify main assumptions of the global workspace theory (GWT), such as the existence of highly segregated information processing during effortless tasks performance, engagement of multiple distributed networks during effortful tasks and the critical role of long-range connections in workspace formation. A number of studies support the assumptions of GWT by showing the reorganization of the whole-brain functional network during cognitive task performance; however, the involvement of specific large scale networks in the formation of workspace is still not well-understood...
April 22, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28432768/the-fate-of-recently-fixed-carbon-after-drought-release-towards-unravelling-c-storage-regulation-in-tilia-platyphyllos-and-pinus-sylvestris
#8
Lucía Galiano Pérez, Galina Timofeeva, Matthias Saurer, Rolf Siegwolf, Jordi Martínez-Vilalta, Robert Hommel, Arthur Gessler
Carbon reserves are important for maintaining tree function during and after stress. Increasing tree mortality driven by drought globally has renewed the interest in how plants regulate allocation of recently fixed C to reserve formation. Three year-old seedlings of two species (Tilia platyphyllos, Pinus sylvestris) were exposed to two intensities of experimental drought during ~ 10 weeks and (13) C pulse labelling was subsequently applied with rewetting. Tracking the (13) C-label across different organs and C compounds (soluble sugars, starch, myo-inositol, lipids and cellulose), together with the monitoring of gas exchange and C mass balances over time, allowed for the identification of variations in C allocation priorities and tree C balances that are associated to drought effects and subsequent drought release...
April 22, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28432751/acute-kidney-injury-plasma-lactate-concentrations-and-lactic-acidosis-in-metformin-users-a-godarts-study
#9
Paul J Connelly, Mike Lonergan, Enrique Soto-Pedre, Louise Donnelly, Kaixin Zhou, Ewan R Pearson
AIMS: Metformin is renally excreted and has been associated with the development of lactic acidosis. Although current advice is to omit metformin during illnesses that may increase risk of acute kidney injury (AKI), the evidence supporting this is lacking. We investigated the relationship between AKI, lactate concentrations and the risk of lactic acidosis in those exposed to metformin. METHODS: We undertook a population-based case-control study of lactic acidosis in 1,746 participants with Type 2 diabetes and 846 individuals without diabetes with clinically measured lactates with and without AKI between 1994-2014...
April 21, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28432743/global-and-local-visual-processing-in-autism-an-objective-assessment-approach
#10
Kritika Nayar, Angela C Voyles, Lynne Kiorpes, Adriana Di Martino
We examined global and local visual processing in autism spectrum disorder (ASD) via a match-to-sample task using Kanizsa illusory contours (KIC). School-aged children with ASD (n = 28) and age-matched typically developing controls (n = 22; 7-13 years) performed a sequential match-to-sample between a solid shape (sample) and two illusory alternatives. We tracked eye gaze and behavioral performance in two task conditions: one with and one without local interference from background noise elements. While analyses revealed lower accuracy and longer reaction time in ASD in the condition with local interference only, eye tracking robustly captured ASD-related global atypicalities across both conditions...
April 22, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28432681/retrospective-single-center-study-of-the-efficacy-of-large-spot-532%C3%A2-nm-laser-for-the-treatment-of-facial-capillary-malformations-in-44-patients-with-the-use-of-three-dimensional-image-analysis
#11
Bartłomiej Kwiek, Michał Rożalski, Cezary Kowalewski, Marcin Ambroziak
OBJECTIVE: We wanted to asses the efficacy of large spot 532 nm laser for the treatment of facial capillary malformations with the use of three-dimensional (3D) image analysis. STUDY DESIGN AND METHODS: Retrospective single center study on previously non-treated patients with facial capillary malformations (CM) was performed. A total of 44 consecutive Caucasian patients aged 5-66 were included. Patients had 3D photography performed before and after and had at least one single session of treatment with 532 nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser with contact cooling, fluencies ranging from 8 to 11...
April 22, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28432637/polluted-pathways-mechanisms-of-metabolic-disruption-by-endocrine-disrupting-chemicals
#12
REVIEW
Mizuho S Mimoto, Angel Nadal, Robert M Sargis
PURPOSE OF REVIEW: Environmental toxicants are increasingly implicated in the global decline in metabolic health. Focusing on diabetes, herein, the molecular and cellular mechanisms by which metabolism disrupting chemicals (MDCs) impair energy homeostasis are discussed. RECENT FINDINGS: Emerging data implicate MDC perturbations in a variety of pathways as contributors to metabolic disease pathogenesis, with effects in diverse tissues regulating fuel utilization...
April 21, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28432632/tryptophan-fluorescence-yields-and-lifetimes-as-a-probe-of-conformational-changes-in-human-glucokinase
#13
Bogumil Zelent, Chris Bialas, Ignacy Gryczynski, Pan Chen, Rahul Chib, Karina Lewerissa, Maria G Corradini, Richard D Ludescher, Jane M Vanderkooi, Franz M Matschinsky
Five variants of glucokinase (ATP-D-hexose-6-phosphotransferase, EC 2.7.1.1) including wild type and single Trp mutants with the Trp residue at positions 65, 99, 167 and 257 were prepared. The fluorescence of Trp in all locations studied showed intensity changes when glucose bound, indicating that conformational change occurs globally over the entire protein. While the fluorescence quantum yield changes upon glucose binding, the enzyme's absorption spectra, emission spectra and fluorescence lifetimes change very little...
April 22, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28432567/less-approach-more-avoidance-response-inhibition-has-motivational-consequences-for-sexual-stimuli-that-reflect-changes-in-affective-value-not-a-lingering-global-brake-on-behavior
#14
Rachel L Driscoll, Keelia Quinn de Launay, Mark J Fenske
Response inhibition negatively impacts subsequent hedonic evaluations of motivationally relevant stimuli and reduces the behavioral incentive to seek and obtain such items. Here we expand the investigation of the motivational consequences of inhibition by presenting sexually appealing and nonappealing images in a go/no-go task and a subsequent image-viewing task. Each initially obscured image in the viewing task could either be made more visible or less visible by repeatedly pressing different keys. Fewer key presses were made to obtain better views of preferred-sex images when such images had previously been inhibited as no-go items than when previously encountered as noninhibited go items...
April 21, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28432484/complete-mitochondrial-genome-sequences-of-korean-native-horse-from-jeju-island-uncovering-the-spatio-temporal-dynamics
#15
Sook Hee Yoon, Jaemin Kim, Donghyun Shin, Seoae Cho, Woori Kwak, Hak-Kyo Lee, Kyoung-Do Park, Heebal Kim
The Korean native horse (Jeju horse) is one of the most important animals in Korean historical, cultural, and economical viewpoints. In the early 1980s, the Jeju horse was close to extinction. The aim of this study is to explore the phylogenomics of Korean native horse focusing on spatio-temporal dynamics. We determined complete mitochondrial genome sequences for the first Korean native (n = 6) and additional Mongolian (n = 2) horses. Those sequences were analyzed together with 143 published ones using Bayesian coalescent approach as well as three different phylogenetic analysis methods, Bayesian inference, maximum likelihood, and neighbor-joining methods...
April 21, 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28432457/outcome-and-revision-rate-of-uncemented-glenohumeral-resurfacing-c-a-p-after-5-8%C3%A2-years
#16
P C Geervliet, M P J van den Bekerom, P Spruyt, M Curvers, A van Noort, C P J Visser
BACKGROUND: Resurfacing of the glenohumeral joint for patients with glenohumeral arthritis has gained popularity since the first introduction. We report the mid-term results of the Global C.A.P. uncemented resurfacing shoulder prosthesis (DePuy Synthes). METHODS: From January 2007 to December 2009, 48 humeral cementless resurfacing prostheses in 46 patients were performed. All patients were diagnosed with primary glenohumeral osteoarthritis. Patients were contacted for review; the Constant Score, visual analog pain scale, Dutch Simple Shoulder Test, SF-12 scores and physical examination were assessed both preoperatively and yearly postoperatively...
April 21, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28432378/advances-in-anti-viral-immune-defence-revealing-the-importance-of-the-ifn-jak-stat-pathway
#17
REVIEW
Nicola Raftery, Nigel J Stevenson
Interferon-alpha (IFN-α) is a potent anti-viral cytokine, critical to the host immune response against viruses. IFN-α is first produced upon viral detection by pathogen recognition receptors. Following its expression, IFN-α embarks upon a complex downstream signalling cascade called the JAK/STAT pathway. This signalling pathway results in the expression of hundreds of effector genes known as interferon stimulated genes (ISGs). These genes are the basis for an elaborate effector mechanism and ultimately, the clearance of viral infection...
April 21, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28432305/systematic-synergy-of-glucose-and-glp-1-to-stimulate-insulin-secretion-revealed-by-quantitative-phosphoproteomics
#18
Jia-Shu Tang, Qing-Run Li, Jia-Ming Li, Jia-Rui Wu, Rong Zeng
GLP-1 synergizes with glucose in regulating pancreatic β-cell function, including facilitating β-cell survival and insulin secretion. Though it has been widely accepted that phosphorylation is extremely important in regulating β-cell functions, our knowledge to the global mechanism is still limited. Here we performed a quantitative phosphoproteomics study to systematically present the synergistic regulation of INS-1E cell phosphoproteome mediated by glucose and GLP-1. We generated the largest pancreatic β-cell phosphoproteome by identifying 25,327 accurately localized phosphorylation sites on 5,389 proteins...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28432292/created-mangrove-wetlands-store-belowground-carbon-and-surface-elevation-change-enables-them-to-adjust-to-sea-level-rise
#19
Ken W Krauss, Nicole Cormier, Michael J Osland, Matthew L Kirwan, Camille L Stagg, Janet A Nestlerode, Marc J Russell, Andrew S From, Amanda C Spivak, Darrin D Dantin, James E Harvey, Alejandro E Almario
Mangrove wetlands provide ecosystem services for millions of people, most prominently by providing storm protection, food and fodder. Mangrove wetlands are also valuable ecosystems for promoting carbon (C) sequestration and storage. However, loss of mangrove wetlands and these ecosystem services are a global concern, prompting the restoration and creation of mangrove wetlands as a potential solution. Here, we investigate soil surface elevation change, and its components, in created mangrove wetlands over a 25 year developmental gradient...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28432256/global-sensitivity-analysis-of-onguard-models-identifies-key-hubs-for-transport-interaction-in-stomatal-dynamics
#20
Silvere Rm Vialet-Chabrand, Adrian Hills, Yizhou Wang, Howard Griffiths, Virgilio Lew, Tracy Lawson, Mike R Blatt, Simon Rogers
The physical requirement for charge to balance across biological membranes means that transmembrane transport of each ionic species is inter-related, and manipulating solute flux through any one transporter will affect other transporters at the same membrane, often with unforeseen consequences. The OnGuard systems modelling platform has helped to resolve the mechanics of stomatal movements, uncovering previously unexpected behaviors of stomata. To date, however, the manual approach to exploring model parameter space has captured little formal information about the emergent connections between parameters that define the most interesting properties of the system as a whole...
April 21, 2017: Plant Physiology
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