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Temístocles Italo de Santana, Miria de Oliveira Barbosa, Paulo André Teixeira de Moraes Gomes, Anne Cecília Nascimento da Cruz, Teresinha Gonçalves da Silva, Ana Cristina Lima Leite
Thiazole derivatives are recognized to possess various biological activities as antiparasitic, antifungal, antimicrobial and antiproliferative. The present work reports the synthesis of 22 new substances belonging to two classes of compounds: thiosemicarbazones and thiazoles, with the purpose of developing new drugs that present high specificity for tumor cells and low toxicity to the organism. A cytotoxic screening was performed to evaluate the performance of the new derivatives in five tumor cell lines. Eight compounds were shown to be promising in at least three tumor cell lines...
December 14, 2017: European Journal of Medicinal Chemistry
Cynthia Layse Ferreira de Almeida, Samara Alves Brito, Temístocles Italo de Santana, Henrique Bandeira Alves Costa, Carlson Helder Reis de Carvalho Júnior, Márcia Vanusa da Silva, Lécio Leone de Almeida, Larissa Araújo Rolim, Vanda Lucia Dos Santos, Almir Gonçalves Wanderley, Teresinha Gonçalves da Silva
Spondias purpurea is used in folk medicine to treat diarrhea and diuresis. The objective of this study was to evaluate the phytochemical profile and antioxidant and antiulcer activities of the hexane extract of the leaves of S. purpurea (SpHE). Phytochemical profile was evaluated via thin layer chromatography (TLC) and HPLC. SpHE was screened for antioxidant activities using DPPH, ABTS, FRAP, and phosphomolybdenum assays. To determine its antiulcer properties, animals were pretreated with injured control, lansoprazole, ranitidine, carbenoxolone, or SpHE (12...
2017: Oxidative Medicine and Cellular Longevity
Valber Onofre de Araújo, Temístocles Soares Oliveira Neto, Sara Vilar Dantas Simões, Thatyana Kelly Ferreira da Silva, Franklin Riet-Correa, Ricardo Barbosa Lucena
Farmers from Paraiba state, Northeast Brazil, claim that Malachra fasciata causes cutaneous lesions in sheep. To test its toxicity the plant was harvested daily and fed ad libitum for 21 days to 3 sheep as the sole food source (# 1-3). An additional sheep (# 4) was maintained as a control. Cutaneous lesions of photosensitization initiated after 7 days and increased continuously over the next 21 days. The dose ingested varied between 129 g/kg to 175 g/kg. Alopecia, hyperemia and crusting were observed in the animals...
November 2017: Toxicon: Official Journal of the International Society on Toxinology
Temístocles Soares de Oliveira Neto, Franklin Riet-Correa, Stephen T Lee, Daniel Cook, Francisca Maria Sousa Barbosa, José Ferreira da Silva Neto, Sara Vilar Dantas Simões, Ricardo Barbosa Lucena
The epidemiological, clinical and pathological aspects of a spontaneous outbreak of Palicourea aeneofusca poisoning in goats are reported. The main clinical signs were motor incoordination, generalized muscle tremors, broad-based posture, tachypnea, tachycardia, vocalization and respiratory distress. Two goats died 5 and 20 min after the observation of the first clinical signs. Another that was found recumbent died 80 h later. One goat with mild clinical signs recovered. Congestion and hemorrhages were observed macroscopically and histologically in most organs...
May 31, 2017: Toxicon: Official Journal of the International Society on Toxinology
Carolina Luttges D, Carolina Leyton M, Ingrid Leal F, Paulina Troncoso E, Temístocles Molina G
BACKGROUND: Teenage pregnancy is a psychosocial and multifactorial problem described as a lack of exercise of rights in sexual and reproductive health. There are important aspects in the doctor-patient relationship and confidentiality that directly affect the continuity and quality of care. There are controversies in the laws relating to the provision of contraception and confidentiality, and those that protect the sexual indemnity, especially in adolescents under 14 years. AIM: To describe the implications of the legal framework for professional midwives in the care of adolescents younger than 14 years in sexual and reproductive health...
October 2016: Revista Médica de Chile
Ingrid Leal, Carolina Luttges, Paulina Troncoso, Carolina Leyton, Temistocles Molina, Pamela Eguiguren
BACKGROUND: There are legal regulations about sexual and reproductive rights of adolescents. However, this legal framework (LF) may have contradictory elements: there are laws assuring confidentiality and access to contraception at any age but there are other laws that consider any sexual contact with an adolescent younger than 14 a sexual assault, whose report to the legal authorities in mandatory. AIM: To explore the knowledge and clinical practice of primary health care (PHC) providers regarding prevention of teenage pregnancy...
May 2016: Revista Médica de Chile
Electra González A, Vania Martínez N, Temistocles Molina G, Myriam George L, Rodrigo SepúLveda P, Ramiro Molina C, Carlos Hidalgo-Rasmussen
BACKGROUND: Health-related quality of life (HRQOL) refers to individuals' perception of their subjective well-being, considering various aspects of their life and the impact on their health. AIM: To analyze gender differences in the HRQOL of adolescent students in Chile, by age, type of school attended, and area of residence. MATERIAL AND METHODS: Analytical cross-sectional study conducted in a population of 5th and 12th grade students attending municipal, subsidized and private schools in 11 regions of the country...
March 2016: Revista Médica de Chile
Celeste Montecchiani, Lucia Pedace, Temistocle Lo Giudice, Antonella Casella, Marzia Mearini, Fabrizio Gaudiello, José L Pedroso, Chiara Terracciano, Carlo Caltagirone, Roberto Massa, Peter H St George-Hyslop, Orlando G P Barsottini, Toshitaka Kawarai, Antonio Orlacchio
Charcot-Marie-Tooth disease is a group of hereditary peripheral neuropathies that share clinical characteristics of progressive distal muscle weakness and atrophy, foot deformities, distal sensory loss, as well as diminished tendon reflexes. Hundreds of causative DNA changes have been found, but much of the genetic basis of the disease is still unexplained. Mutations in the ALS5/SPG11/KIAA1840 gene are a frequent cause of autosomal recessive hereditary spastic paraplegia with thin corpus callosum and peripheral axonal neuropathy, and account for ∼ 40% of autosomal recessive juvenile amyotrophic lateral sclerosis...
January 2016: Brain: a Journal of Neurology
Carlos Hidalgo-Rasmussen, Temístocles Molina, Ramiro Molina, Rodrigo Sepúlveda, Vania Martínez, Rosa Montaño, Electra González, Myriam George
BACKGROUND: Bullying has a negative impact on the perception of adolescents of their quality of life. AIM: To analyze the association between being bullied and health related quality of life in Chilean adolescents. MATERIAL AND METHODS: The bullying module of the KIDSCREEN 52 survey and the KIDSCREEN 10 survey to assess health related quality of life were applied to 7737 students aged 10 to 18 years. Social and demographic data, information about disability and type of school were also gathered...
June 2015: Revista Médica de Chile
Temístocles Molina G, Rosa Montaño E, Electra González A, Rodrigo Sepúlveda P, Carlos Hidalgo-Rasmussen, Vania Martínez N, Ramiro Molina C, Myriam George L
BACKGROUND: KIDSCREEN-52, which assesses health related quality of life in adolescents, has been adapted and validated in Chile showing excellent psychometric properties. There is a shorter version of the instrument, whose psychometric properties must be assessed. AIM: To evaluate the psychometric properties of the instrument KIDSCREEN-27 in Chilean adolescents. MATERIAL AND METHODS: A secondary analysis of the database obtained for the adaptation and validation of KIDSCREEN-52...
November 2014: Revista Médica de Chile
Angela Guerriero, Paolo Giovenali, Roberta La Starza, Cristina Mecucci, Giampaolo Montesi, Stefano Pasquino, Tiziana Pierini, Temistocle Ragni, Angelo Sidoni
Although multiple primary malignancies are relatively rare, they have increased in frequency over the last decades, partly because of advances in diagnosis and therapy. This report describes for the first time the case of a patient with past occupational exposure to asbestos and no family history of cancer who developed 2 rare primary malignancies: a cardiac sarcoma and a gliosarcoma 11 months later. Molecular-cytogenetic studies did not identify common lesions to these 2 rare metachronous sarcomas. The gliosarcoma was associated with monosomy 10 and underlying PTEN monoallelic loss, which has been recurrently observed...
March 2015: Human Pathology
Irwin R A Menezes, Temístocles I Santana, Victor J C Varela, Rogerio A Saraiva, Edinardo F F Matias, Aline A Boligon, Margareth L Athayde, Henrique D M Coutinho, Jose G M Costa, João B T Rocha
CONTEXT: Murraya paniculata (Linn) JACK (Rutaceae) is used in traditional medicine in the treatment of diabetes, inflammation, and microbial disorders. OBJECTIVE: This study determined the polyphenol composition and antimicrobial and acute toxicological activity of the hydroethanolic extract of M. paniculata leaves (EEMp). MATERIALS AND METHODS: Chemical composition was evaluated by the Folin-Ciocalteu and AlCl3 assays and by HPLC-DAD. Antibacterial and modulatory activity was determined by the microdilution method...
February 2015: Pharmaceutical Biology
Uberto Da Col, Davide Di Lazzaro, Alessandro Affronti, Simone Perticoni, Temistocle Ragni
OBJECTIVES: The optimal surgical management of chronic ischemic mitral regurgitation has not yet been clearly defined. Among the various approaches proposed, the excision of strut (or main) chordae, along with complete annuloplasty to relieve tethering, has been the one preferred by our institution to treat this particular subset of mitral disease. METHODS: Between October 2004 and May 2013, 11 patients underwent surgery for chronic ischemic mitral regurgitation...
September 2014: Journal of Cardiac Surgery
Alessandro Affronti, Isidoro Di Bella, Davide Di Lazzaro, Rosanna Capozzi, Elisa Scarnecchia, Temistocle Ragni
: Penetrating injuries of the heart caused by migrating needles have been rarely described. They usually occur accidentally or are self-inflicted in the setting of an underlying psychiatric disorder. We present an unusual case of cardiac tamponade caused by a sewing needle that migrated to the heart from the chest wall through the lung. The lesions were successfully repaired through a median sternotomy without cardiopulmonary bypass. The pathophysiological mechanism and the pertinent literature are briefly analysed...
December 2016: Journal of Cardiovascular Medicine
Temistocle Lo Giudice, Federica Lombardi, Filippo Maria Santorelli, Toshitaka Kawarai, Antonio Orlacchio
Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous neurological disorders characterized by pathophysiologic hallmark of length-dependent distal axonal degeneration of the corticospinal tracts. The prominent features of this pathological condition are progressive spasticity and weakness of the lower limbs. To date, 72 spastic gait disease-loci and 55 spastic paraplegia genes (SPGs) have been identified. All modes of inheritance (autosomal dominant, autosomal recessive, and X-linked) have been described...
November 2014: Experimental Neurology
Rodrigo Sepúlveda P, Temístocles Molina G, Ramiro Molina C, Vania Martínez N, Electra González A, Myriam George L, Rosa Montaño E, Carlos Hidalgo-Rasmussen
BACKGROUND: KIDSCREEN-52 is an instrument to assess health related quality of life in children and adolescents. AIM: To culturally adapt and validate the KIDSCREEN-52 questionnaire in Chileans. MATERIAL AND METHODS: Two independent translations from the English Spanish language were conciliated and retranslated to English. The conciliated version was tested during a cognitive interview to adolescents of different socioeconomic levels. The final version was validated in 7,910 school attending adolescents...
October 2013: Revista Médica de Chile
Alessandro Affronti, Isidoro di Bella, Davide Carino, Temistocle Ragni
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides temporary mechanical circulatory support in patients with refractory cardiogenic shock, allowing time for cardiac recovery. Levosimendan is a calcium sensitizer with inotropic and vasodilatory effects used in the treatment of severe heart failure. It does not increase myocardial oxygen consumption. Its maximum hemodynamic response is seen 24-48 h after stopping infusion, but its effects can persist for 7-9 d owing to active metabolites. We sought to investigate whether the use of levosimendan improves weaning outcomes in patients on VA-ECMO...
November 2013: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Isidoro Di Bella, Alessandro Affronti, Uberto Da Col, Simone Perticoni, Paolo Procenesi, Temistocle Ragni
Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is the treatment of choice for cardiogenic shock unresponsive to inotropes or intra-aortic balloon pumping. It provides a temporary mechanical circulatory support and blood oxygenation allowing time for cardiac recovery. If this is not the case, the patient may become suitable for heart transplantation or left ventricular assist device (LVAD) implantation and must be transferred to a referral center. In this setting, patient transport is asscociated with high risk and it is also difficult from a logistic point of view...
September 2013: Giornale Italiano di Cardiologia
Electra González A, Temístocles Molina G, Adela Montero V, Vania Martínez N
BACKGROUND: Nowadays, adolescent population begins sexual activity earlier, a behavior with negative psychological ana social consequences. AIM: To determine the association between family factors and early sexual activity in adolescents of low and middle socioeconomic level. MATERIAL AND METHODS: A sample of 3,210 adolescents, who confidentially requested care in a sexual and reproductive health university center, between 2000 and 2007, was analyzed...
March 2013: Revista Médica de Chile
Claudia Castellani, Isidoro Di Bella, Michele Duranti, Enrichetta Corgna, Paolo Giovenali, Temistocle Ragni, Claudio Cavallini
Metastasis to the heart from malignancy is a frequent but underestimated event. Tumors that are located in the mediastinum, such as pleural mesothelioma, are more frequently associated with cardiac colonization. Few reports have described metastasis from colon adenocarcinoma, which usually colonizes liver and lungs. Moreover, intracardiac localization is more common for primary cardiac neoplasms than for metastasis. We present an unusual case of a patient operated for colon adenocarcinoma who exhibited a single intracardiac secondary localization...
June 2013: Giornale Italiano di Cardiologia
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