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https://www.readbyqxmd.com/read/27552007/-the-legal-framework-to-prevent-teenage-pregnancies
#1
Ingrid Leal, Carolina Luttges, Paulina Troncoso, Carolina Leyton, Temistocles Molina, Pamela Eguiguren
BACKGROUND: There are legal regulations about sexual and reproductive rights of adolescents. However, this legal framework (LF) may have contradictory elements: there are laws assuring confidentiality and access to contraception at any age but there are other laws that consider any sexual contact with an adolescent younger than 14 a sexual assault, whose report to the legal authorities in mandatory. AIM: To explore the knowledge and clinical practice of primary health care (PHC) providers regarding prevention of teenage pregnancy...
May 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27299815/-gender-differences-in-health-related-quality-of-life-of-chilean-adolescent-students
#2
Electra González A, Vania Martínez N, Temistocles Molina G, Myriam George L, Rodrigo SepúLveda P, Ramiro Molina C, Carlos Hidalgo-Rasmussen
BACKGROUND: Health-related quality of life (HRQOL) refers to individuals' perception of their subjective well-being, considering various aspects of their life and the impact on their health. AIM: To analyze gender differences in the HRQOL of adolescent students in Chile, by age, type of school attended, and area of residence. MATERIAL AND METHODS: Analytical cross-sectional study conducted in a population of 5th and 12th grade students attending municipal, subsidized and private schools in 11 regions of the country...
March 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/26556829/als5-spg11-kiaa1840-mutations-cause-autosomal-recessive-axonal-charcot-marie-tooth-disease
#3
Celeste Montecchiani, Lucia Pedace, Temistocle Lo Giudice, Antonella Casella, Marzia Mearini, Fabrizio Gaudiello, José L Pedroso, Chiara Terracciano, Carlo Caltagirone, Roberto Massa, Peter H St George-Hyslop, Orlando G P Barsottini, Toshitaka Kawarai, Antonio Orlacchio
Charcot-Marie-Tooth disease is a group of hereditary peripheral neuropathies that share clinical characteristics of progressive distal muscle weakness and atrophy, foot deformities, distal sensory loss, as well as diminished tendon reflexes. Hundreds of causative DNA changes have been found, but much of the genetic basis of the disease is still unexplained. Mutations in the ALS5/SPG11/KIAA1840 gene are a frequent cause of autosomal recessive hereditary spastic paraplegia with thin corpus callosum and peripheral axonal neuropathy, and account for ∼ 40% of autosomal recessive juvenile amyotrophic lateral sclerosis...
January 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/26230554/-influence-of-bullying-on-the-quality-of-life-perception-of-chilean-students
#4
Carlos Hidalgo-Rasmussen, Temístocles Molina, Ramiro Molina, Rodrigo Sepúlveda, Vania Martínez, Rosa Montaño, Electra González, Myriam George
BACKGROUND: Bullying has a negative impact on the perception of adolescents of their quality of life. AIM: To analyze the association between being bullied and health related quality of life in Chilean adolescents. MATERIAL AND METHODS: The bullying module of the KIDSCREEN 52 survey and the KIDSCREEN 10 survey to assess health related quality of life were applied to 7737 students aged 10 to 18 years. Social and demographic data, information about disability and type of school were also gathered...
June 2015: Revista Médica de Chile
https://www.readbyqxmd.com/read/25694287/-psychometric-properties-of-the-quality-of-life-questionnaire-health-related-kidscreen-27-in-chilean-adolescents
#5
Temístocles Molina G, Rosa Montaño E, Electra González A, Rodrigo Sepúlveda P, Carlos Hidalgo-Rasmussen, Vania Martínez N, Ramiro Molina C, Myriam George L
BACKGROUND: KIDSCREEN-52, which assesses health related quality of life in adolescents, has been adapted and validated in Chile showing excellent psychometric properties. There is a shorter version of the instrument, whose psychometric properties must be assessed. AIM: To evaluate the psychometric properties of the instrument KIDSCREEN-27 in Chilean adolescents. MATERIAL AND METHODS: A secondary analysis of the database obtained for the adaptation and validation of KIDSCREEN-52...
November 2014: Revista Médica de Chile
https://www.readbyqxmd.com/read/25586016/metachronous-cardiac-and-cerebral-sarcomas-case-report-with-focus-on-molecular-findings-and-review-of-the-literature
#6
REVIEW
Angela Guerriero, Paolo Giovenali, Roberta La Starza, Cristina Mecucci, Giampaolo Montesi, Stefano Pasquino, Tiziana Pierini, Temistocle Ragni, Angelo Sidoni
Although multiple primary malignancies are relatively rare, they have increased in frequency over the last decades, partly because of advances in diagnosis and therapy. This report describes for the first time the case of a patient with past occupational exposure to asbestos and no family history of cancer who developed 2 rare primary malignancies: a cardiac sarcoma and a gliosarcoma 11 months later. Molecular-cytogenetic studies did not identify common lesions to these 2 rare metachronous sarcomas. The gliosarcoma was associated with monosomy 10 and underlying PTEN monoallelic loss, which has been recurrently observed...
March 2015: Human Pathology
https://www.readbyqxmd.com/read/25255929/chemical-composition-and-evaluation-of-acute-toxicological-antimicrobial-and-modulatory-resistance-of-the-extract-of-murraya-paniculata
#7
Irwin R A Menezes, Temístocles I Santana, Victor J C Varela, Rogerio A Saraiva, Edinardo F F Matias, Aline A Boligon, Margareth L Athayde, Henrique D M Coutinho, Jose G M Costa, João B T Rocha
CONTEXT: Murraya paniculata (Linn) JACK (Rutaceae) is used in traditional medicine in the treatment of diabetes, inflammation, and microbial disorders. OBJECTIVE: This study determined the polyphenol composition and antimicrobial and acute toxicological activity of the hydroethanolic extract of M. paniculata leaves (EEMp). MATERIALS AND METHODS: Chemical composition was evaluated by the Folin-Ciocalteu and AlCl3 assays and by HPLC-DAD. Antibacterial and modulatory activity was determined by the microdilution method...
February 2015: Pharmaceutical Biology
https://www.readbyqxmd.com/read/25039820/nine-years-experience-with-the-chordal-cutting-technique-in-ischemic-mitral-regurgitation
#8
Uberto Da Col, Davide Di Lazzaro, Alessandro Affronti, Simone Perticoni, Temistocle Ragni
OBJECTIVES: The optimal surgical management of chronic ischemic mitral regurgitation has not yet been clearly defined. Among the various approaches proposed, the excision of strut (or main) chordae, along with complete annuloplasty to relieve tethering, has been the one preferred by our institution to treat this particular subset of mitral disease. METHODS: Between October 2004 and May 2013, 11 patients underwent surgery for chronic ischemic mitral regurgitation...
September 2014: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/24979123/cardiac-tamponade-caused-by-a-migrating-sewing-needle
#9
Alessandro Affronti, Isidoro Di Bella, Davide Di Lazzaro, Rosanna Capozzi, Elisa Scarnecchia, Temistocle Ragni
Penetrating injuries of the heart caused by migrating needles have been rarely described. They usually occur accidentally or are self-inflicted in the setting of an underlying psychiatric disorder. We present an unusual case of cardiac tamponade caused by a sewing needle that migrated to the heart from the chest wall through the lung. The lesions were successfully repaired through a median sternotomy without cardiopulmonary bypass. The pathophysiological mechanism and the pertinent literature are briefly analysed...
June 28, 2014: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/24954637/hereditary-spastic-paraplegia-clinical-genetic-characteristics-and-evolving-molecular-mechanisms
#10
REVIEW
Temistocle Lo Giudice, Federica Lombardi, Filippo Maria Santorelli, Toshitaka Kawarai, Antonio Orlacchio
Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous neurological disorders characterized by pathophysiologic hallmark of length-dependent distal axonal degeneration of the corticospinal tracts. The prominent features of this pathological condition are progressive spasticity and weakness of the lower limbs. To date, 72 spastic gait disease-loci and 55 spastic paraplegia genes (SPGs) have been identified. All modes of inheritance (autosomal dominant, autosomal recessive, and X-linked) have been described...
November 2014: Experimental Neurology
https://www.readbyqxmd.com/read/24522356/-validation-of-an-instrument-to-measure-health-related-quality-of-life-in-chilean-children-and-adolescents
#11
Rodrigo Sepúlveda P, Temístocles Molina G, Ramiro Molina C, Vania Martínez N, Electra González A, Myriam George L, Rosa Montaño E, Carlos Hidalgo-Rasmussen
BACKGROUND: KIDSCREEN-52 is an instrument to assess health related quality of life in children and adolescents. AIM: To culturally adapt and validate the KIDSCREEN-52 questionnaire in Chileans. MATERIAL AND METHODS: Two independent translations from the English Spanish language were conciliated and retranslated to English. The conciliated version was tested during a cognitive interview to adolescents of different socioeconomic levels. The final version was validated in 7,910 school attending adolescents...
October 2013: Revista Médica de Chile
https://www.readbyqxmd.com/read/24172260/levosimendan-may-improve-weaning-outcomes-in-venoarterial-ecmo-patients
#12
Alessandro Affronti, Isidoro di Bella, Davide Carino, Temistocle Ragni
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides temporary mechanical circulatory support in patients with refractory cardiogenic shock, allowing time for cardiac recovery. Levosimendan is a calcium sensitizer with inotropic and vasodilatory effects used in the treatment of severe heart failure. It does not increase myocardial oxygen consumption. Its maximum hemodynamic response is seen 24-48 h after stopping infusion, but its effects can persist for 7-9 d owing to active metabolites. We sought to investigate whether the use of levosimendan improves weaning outcomes in patients on VA-ECMO...
November 2013: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/23903282/-case-report-of-a-patient-on-extracorporeal-memebrane-oyxgenation-for-cardiogenic-shock-not-suitable-for-weaning-in-a-peripheral-center-just-a-problem-or-is-it-feasible-a-treatment-before-patient-transfer-to-a-hub-center
#13
Isidoro Di Bella, Alessandro Affronti, Uberto Da Col, Simone Perticoni, Paolo Procenesi, Temistocle Ragni
Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is the treatment of choice for cardiogenic shock unresponsive to inotropes or intra-aortic balloon pumping. It provides a temporary mechanical circulatory support and blood oxygenation allowing time for cardiac recovery. If this is not the case, the patient may become suitable for heart transplantation or left ventricular assist device (LVAD) implantation and must be transferred to a referral center. In this setting, patient transport is asscociated with high risk and it is also difficult from a logistic point of view...
September 2013: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/23900321/-factors-associated-with-early-sexual-activity-among-chilean-adolescents
#14
Electra González A, Temístocles Molina G, Adela Montero V, Vania Martínez N
BACKGROUND: Nowadays, adolescent population begins sexual activity earlier, a behavior with negative psychological ana social consequences. AIM: To determine the association between family factors and early sexual activity in adolescents of low and middle socioeconomic level. MATERIAL AND METHODS: A sample of 3,210 adolescents, who confidentially requested care in a sexual and reproductive health university center, between 2000 and 2007, was analyzed...
March 2013: Revista Médica de Chile
https://www.readbyqxmd.com/read/23748546/-single-cardiac-metastasis-from-colorectal-cancer-an-unusual-localization
#15
Claudia Castellani, Isidoro Di Bella, Michele Duranti, Enrichetta Corgna, Paolo Giovenali, Temistocle Ragni, Claudio Cavallini
Metastasis to the heart from malignancy is a frequent but underestimated event. Tumors that are located in the mediastinum, such as pleural mesothelioma, are more frequently associated with cardiac colonization. Few reports have described metastasis from colon adenocarcinoma, which usually colonizes liver and lungs. Moreover, intracardiac localization is more common for primary cardiac neoplasms than for metastasis. We present an unusual case of a patient operated for colon adenocarcinoma who exhibited a single intracardiac secondary localization...
June 2013: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/23574166/frailty-among-alzheimer-s-disease-patients
#16
REVIEW
Giacomo Koch, Lorena Belli, Temistocle Lo Giudice, Francesco Di Lorenzo, Giulia Maria Sancesario, Roberto Sorge, Sergio Bernardini, Alessandro Martorana
Alzheimer's disease (AD) is strictly connected with aging and frailty. Although dementia contributes to frailty, it is not well established whether AD patients could be per se defined "frail". At the same time, it is not known whether among AD patients, which are a heterogeneous group of patients, it is possible to identify a subgroup of frail individuals. In this work we sought indices useful to identify "the frail AD". To do this we evaluated disease progression rate and response to pharmacological treatment (Mini Mental State Examination evaluation), cerebrospinal fluid biomarkers (amyloid-β...
June 2013: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/22863599/dopamine-d%C3%A2-agonist-rotigotine-effects-on-cortical-excitability-and-central-cholinergic-transmission-in-alzheimer-s-disease-patients
#17
Alessandro Martorana, Francesco Di Lorenzo, Zaira Esposito, Temistocle Lo Giudice, Giorgio Bernardi, Carlo Caltagirone, Giacomo Koch
Dopamine is a neurotransmitter involved in several brain functions ranging from emotions control, movement organization to memory formation. It is also involved in the regulation of mechanisms of synaptic plasticity. However, its role in Alzheimer's disease (AD) pathogenesis is still puzzling. Several recent line of research instead indicates a clear role for dopamine in both amyloid β formation as well as in cognitive decline progression. In particular it has been shown that dopamine D₂-like receptors (namely D₃ and D₂) could be mostly responsible for dopamine dysfunction in AD...
January 2013: Neuropharmacology
https://www.readbyqxmd.com/read/22562132/performance-characteristics-of-pap-test-via-vili-hr-hpv-testing-cervicography-and-colposcopy-in-diagnosis-of-significant-cervical-pathology
#18
MULTICENTER STUDY
Adhemar Longatto-Filho, Paulo Naud, Sophie Fm Derchain, Cecília Roteli-Martins, Sílvio Tatti, Luciano Serpa Hammes, Luis Otavio Sarian, Mojca Eržen, Margherita Branca, Jean Carlos de Matos, Renata Gontijo, Marina Y S Maeda, Temístocles Lima, Silvano Costa, Stina Syrjänen, Kari Syrjänen
We sought to evaluate the performance of diagnostic tools to establish an affordable setting for early detection of cervical cancer in developing countries. We compared the performance of different screening tests and their feasibility in a cohort of over 12,000 women: conventional Pap smear, liquid-based cytology, visual inspection with acetic acid (VIA), visual inspection with Iodine solution (VILI), cervicography, screening colposcopy, and high-risk human papillomavirus (HPV) testing (HR-HPV) collected by physician and by self-sampling...
June 2012: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/21863260/potentiation-of-spontaneous-and-evoked-cortical-electrical-activity-after-spreading-depression-in-vivo-analysis-in-well-nourished-and-malnourished-rats
#19
COMPARATIVE STUDY
Thays Kallyne Marinho de Souza, Mariana Barros e Silva, André Ricardson Gomes, Hélio Magalhães de Oliveira, Renato Barros Moraes, Catão Temístocles de Freitas Barbosa, Rubem Carlos Araújo Guedes
Cortical spreading depression (CSD) is influenced by brain excitability and is related to neurological diseases, such as epilepsy. In vitro evidence indicates that neuronal electrical activity is potentiated after CSD. Malnutrition can cause electrophysiological changes in the brain, both in animals and in humans. Here, we investigated in vivo whether CSD potentiates the amplitude of electrocorticogram (ECoG) and of transcallosal evoked responses in adult well-nourished (W), early-malnourished (M), and food-restricted rats...
October 2011: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/21810853/the-curious-affair-of-the-identity-of-fioravanti-sammut-b-1863-and-temistocle-zammit-d-1935
#20
H V Wyatt
Dr Zammit's experiments showed that brucellosis was transmitted by the milk of goats that did not show signs of infection or ill health. The British forces in Malta banned the use of goats' milk and brucellosis was eliminated in those forces. This research was published in the Proceedings of the Royal Society and earned him an Honorary DLitt from Oxford University and the Kingsley Medal of the Liverpool School of Tropical Medicine. The King knighted him. He was the great Maltese polymath but there is a mystery concerning his name...
August 2011: Journal of Medical Biography
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