Franck Verdonk, Pierre Lambert, Clément Gakuba, Anais Charles Nelson, Thomas Lescot, Fanny Garnier, Jean-Michel Constantin, Danielle Saurel, Sigismond Lasocki, Emmanuel Rineau, Pierre Diemunsch, Lucas Dreyfuss, Benoît Tavernier, Lucillia Bezu, Julien Josserand, Alexandre Mebazaa, Marine Coroir, Karine Nouette-Gaulain, Gerard Macouillard, Pauline Glasman, Denis Lemesle, Vincent Minville, Philippe Cuvillon, Brice Gaudilliere, Christophe Quesnel, Pierre Abdel-Ahad, Tarek Sharshar, Serge Molliex, Raphael Gaillard, Jean Mantz
BACKGROUND: Preventive anesthetic impact on the high rates of postoperative neurocognitive disorders in elderly patients is debated. The Prevention of postOperative Cognitive dysfunction by Ketamine (POCK) study aimed to assess the effect of ketamine on this condition. METHODS: This is a multicenter, randomized, double-blind, interventional study. Patients ≥60 years undergoing major orthopedic surgery were randomly assigned in a 1:1 ratio to receive preoperative ketamine 0...
May 4, 2024: Anaesthesia, Critical Care & Pain Medicine