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diagnosis of CTE

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https://www.readbyqxmd.com/read/28338593/clinical-correlates-to-assist-with-cte-diagnosis-insights-from-a-novel-rodent-repeat-concussion-model
#1
Gretchen M Thomsen, Ara Ko, Megan Y Harada, Annie Ma, Livia Wyss, Patricia Haro, Jean-Philippe Vit, Pablo Avalos, Navpreet Dhillon, Noell Cho, Oksana Shelest, Eric J Ley
INTRODUCTION: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repetitive head injuries. CTE symptoms include changes in mood, behavior, cognition and motor function, however CTE is only currently diagnosed post-mortem. Using a rat model of recurrent traumatic brain injury (TBI) we demonstrate rodent deficits that predict the severity of CTE-like brain pathology. METHODS: Bilateral, closed skull, mild TBI was administered once per week to 35 WT rats, 8 rats received 2 injuries ('2xTBI'), 27 rats received 5 injuries ('5xTBI') and 13 rats were sham controls...
March 23, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28214960/axonal-disruption-in-white-matter-underlying-cortical-sulcus-tau-pathology-in-chronic-traumatic-encephalopathy
#2
Laurena Holleran, Joong Hee Kim, Mihika Gangolli, Thor Stein, Victor Alvarez, Ann McKee, David L Brody
Chronic traumatic encephalopathy (CTE) is a progressive degenerative disorder associated with repetitive traumatic brain injury. One of the primary defining neuropathological lesions in CTE, based on the first consensus conference, is the accumulation of hyperphosphorylated tau in gray matter sulcal depths. Post-mortem CTE studies have also reported myelin loss, axonal injury and white matter degeneration. Currently, the diagnosis of CTE is restricted to post-mortem neuropathological analysis. We hypothesized that high spatial resolution advanced diffusion MRI might be useful for detecting white matter microstructural changes directly adjacent to gray matter tau pathology...
March 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28205009/mixed-pathologies-including-chronic-traumatic-encephalopathy-account-for-dementia-in-retired-association-football-soccer-players
#3
Helen Ling, Huw R Morris, James W Neal, Andrew J Lees, John Hardy, Janice L Holton, Tamas Revesz, David D R Williams
In retired professional association football (soccer) players with a past history of repetitive head impacts, chronic traumatic encephalopathy (CTE) is a potential neurodegenerative cause of dementia and motor impairments. From 1980 to 2010, 14 retired footballers with dementia were followed up regularly until death. Their clinical data, playing career, and concussion history were prospectively collected. Next-of-kin provided consent for six to have post-mortem brain examination. Of the 14 male participants, 13 were professional and 1 was a committed amateur...
March 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28058450/collagenous-sprue-cross-sectional-imaging-a-comparative-blinded-study
#4
Badr Al-Bawardy, Shannon P Sheedy, Michelle B Herberts, Joseph A Murray, Alberto Rubio-Tapia, Elizabeth Rajan, David H Bruining, Stephanie L Hansel, John M Barlow, Joel G Fletcher, Jeff L Fidler
PURPOSE: Collagenous sprue (CS) is a rare enteropathy characterized by villous atrophy and a thickened subepithelial collagen band. The aim of this study is to describe the cross-sectional imaging findings of CS. METHODS: A case-control, retrospective study with cases of all CS patients from January 2000 to 2015 was performed. Inclusion criteria were (1) Histopathologic diagnosis and (2) Imaging with computed tomography abdomen/pelvis (CT A/P), CT enterography (CTE), or magnetic resonance enterography within 6 months of small bowel (SB) biopsy...
January 5, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28045023/meta-analytic-bayesian-model-for-differentiating-intestinal-tuberculosis-from-crohn-s-disease
#5
REVIEW
Julajak Limsrivilai, Andrew B Shreiner, Ananya Pongpaibul, Charlie Laohapand, Rewat Boonanuwat, Nonthalee Pausawasdi, Supot Pongprasobchai, Sathaporn Manatsathit, Peter D R Higgins
OBJECTIVES: Distinguishing intestinal tuberculosis (ITB) from Crohn's disease (CD) is difficult, although studies have reported clinical, endoscopic, imaging, and laboratory findings that help to differentiate these two diseases. We aimed to produce estimates of the predictive power of these findings and construct a comprehensive model to predict the probability of ITB vs. CD. METHODS: A systematic literature search for studies differentiating ITB from CD was conducted in MEDLINE, PUBMED, and EMBASE from inception until September 2015...
March 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27895429/potential-model-for-differential-diagnosis-between-crohn-s-disease-and-primary-intestinal-lymphoma
#6
Tian-Yu Zhang, Yun Lin, Rong Fan, Shu-Rong Hu, Meng-Meng Cheng, Mao-Chen Zhang, Li-Wen Hong, Xiao-Lin Zhou, Zheng-Ting Wang, Jie Zhong
AIM: To evaluate the usefulness of different parameters to differentiate Crohn's disease (CD) from primary intestinal lymphoma (PIL). METHODS: The medical records of 85 patients with CD and 56 patients with PIL were reviewed retrospectively. Demographic, clinical, laboratory, endoscopic, and computed tomographic enterography (CTE) parameters were collected. The univariate value of each parameter was analyzed. A differentiation model was established by pooling all the valuable parameters...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27829969/chronic-traumatic-encephalopathy-in-athletes-involved-with-high-impact-sports
#7
Cyrus Safinia, Eric M Bershad, H Brent Clark, Karen SantaCruz, Naila Alakbarova, Jose I Suarez, Afshin A Divani
BACKGROUND AND PURPOSE: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease occurring most commonly in athletes and is caused by repeated concussive or subconcussive blows to the head. The main purpose of this review is to evaluate the published literature on chronic traumatic encephalopathy (CTE) in athletes participating in high-impact sports. In particular, we highlight the significance of concussive and subconcussive impacts in multiple sports, elucidate the differences between clinical/pathological features of CTE and related neurodegenerative diseases, and provide an explanation for the variation in clinical presentation between athletes of different sports...
October 2016: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/27793189/microglial-neuroinflammation-contributes-to-tau-accumulation-in-chronic-traumatic-encephalopathy
#8
Jonathan D Cherry, Yorghos Tripodis, Victor E Alvarez, Bertrand Huber, Patrick T Kiernan, Daniel H Daneshvar, Jesse Mez, Philip H Montenigro, Todd M Solomon, Michael L Alosco, Robert A Stern, Ann C McKee, Thor D Stein
The chronic effects of repetitive head impacts (RHI) on the development of neuroinflammation and its relationship to chronic traumatic encephalopathy (CTE) are unknown. Here we set out to determine the relationship between RHI exposure, neuroinflammation, and the development of hyperphosphorylated tau (ptau) pathology and dementia risk in CTE. We studied a cohort of 66 deceased American football athletes from the Boston University-Veteran's Affairs-Concussion Legacy Foundation Brain Bank as well as 16 non-athlete controls...
October 28, 2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27765734/current-public-knowledge-pertaining-to-traumatic-brain-injury-influence-of-demographic-factors-social-trends-and-sport-concussion-experience-on-the-understanding-of-traumatic-brain-injury-sequelae
#9
Zachary C Merz, Ryan Van Patten, John Lace
OBJECTIVE: The current study aimed to assess current broad traumatic brain injury (TBI)-related knowledge in the general public, as well as understanding regarding specific TBI-related conditions including post-concussive syndrome (PCS) and chronic traumatic encephalopathy (CTE). METHODS: Data were collected from 307 domestic and 73 international individuals via online researcher-developed survey instrumentation utilizing the Amazon Mechanical Turk marketplace, a recently developed website that allows for a streamlined process of survey-based participant recruitment and data collection...
October 20, 2016: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/27741148/unusual-presentation-of-obscure-meckel-diverticulum-treated-with-robot-assisted-diverticulectomy-a-case-report
#10
Sagar Pandey, Miao Fan, Zhe Xu, Chaogui Yan, Junfeng Zhu, Xiuhong Li
INTRODUCTION: Meckel diverticulum (MD) is the most common congenital abnormality of gastrointestinal tract. Tough believed to occur in 2% of population, most of them remain veiled because majority are clinically asymptomatic and remain obscure in radiological examination. CLINICAL FINDINGS AND DIAGNOSIS: A 26-year-old male with episodic black colored stool since last 10 years. Tough symptomatic, diagnosis of pathological lesion, and the bleeding site could not be established with any of the sophisticated diagnostic technique...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27676441/cerebral-18-%C3%A2-f-t807-av1451-retention-pattern-in-clinically-probable-cte-resembles-pathognomonic-distribution-of-cte-tauopathy
#11
D L Dickstein, M Y Pullman, C Fernandez, J A Short, L Kostakoglu, K Knesaurek, L Soleimani, B D Jordan, W A Gordon, K Dams-O'Connor, B N Delman, E Wong, C Y Tang, S T DeKosky, J R Stone, R C Cantu, M Sano, P R Hof, S Gandy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder most commonly associated with repetitive traumatic brain injury (TBI) and characterized by the presence of neurofibrillary tangles of tau protein, known as a tauopathy. Currently, the diagnosis of CTE can only be definitively established postmortem. However, a new positron emission tomography (PET) ligand, [(18)F]T807/AV1451, may provide the antemortem detection of tau aggregates, and thus various tauopathies, including CTE. Our goal was to examine [(18)F]T807/AV1451 retention in athletes with neuropsychiatric symptoms associated with a history of multiple concussions...
September 27, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27632903/fluid-biomarkers-for-mild-traumatic-brain-injury-and-related-conditions
#12
REVIEW
Henrik Zetterberg, Kaj Blennow
Diagnostic and prognostic biomarkers for mild traumatic brain injury (TBI), also known as concussion, remain a major unmet clinical need. Moderate to severe TBI can be diagnosed definitively by clinical assessment and standard neuroimaging techniques that detect the gross damage to the brain parenchyma. Diagnostic tools for mild TBI are lacking and, currently, the diagnosis has to be made on clinical grounds alone, because most patients show no gross pathological changes on CT. Most patients with mild TBI recover quickly, but about 15% develop an ill-defined condition called postconcussive syndrome (PCS)...
October 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27548727/a-prospective-blinded-comparison-of-video-capsule-endoscopy-versus-computed-tomography-enterography-in-potential-small-bowel-bleeding-clinical-utility-of-computed-tomography-enterography
#13
Julajak Limsrivilai, Sitthipong Srisajjakul, Supot Pongprasobchai, Somchai Leelakusolvong, Tawesak Tanwandee
GOALS: To compare the efficacy of video capsule endoscopy (VCE) with computed tomography enterography (CTE) in potential small bowel (SB) bleeding, and to identify factors predictive of a high diagnostic yield for CTE. BACKGROUND: In potential SB bleeding, CTE potentially detects some lesions missed by VCE, but few data have determined its clinical utility. STUDY: Consecutive patients with potential SB bleeding were prospectively enrolled...
August 19, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27543120/chronic-traumatic-encephalopathy-pathology-in-multiple-system-atrophy
#14
Shunsuke Koga, Dennis W Dickson, Kevin F Bieniek
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder associated with repetitive traumatic brain injury. Multiple system atrophy (MSA) is a Parkinsonian disorder that can result in repetitive falls with associated head trauma. We hypothesized that patients with neurodegenerative disorders like MSA could develop CTE pathology. Therefore, we assessed CTE pathology in 139 MSA cases in our brain bank. Sections from convexity cerebral cortices were screened by immunohistochemistry with anti-phospho-tau antibody...
October 2016: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/27527637/evaluation-of-malaria-diagnoses-using-a-handheld-light-microscope-in-a-community-based-setting-in-rural-c%C3%A3-te-d-ivoire
#15
Jean T Coulibaly, Mamadou Ouattara, Jennifer Keiser, Bassirou Bonfoh, Eliézer K N'Goran, Jason R Andrews, Isaac I Bogoch
Portable microscopy may facilitate quality diagnostic care in resource-constrained settings. We compared a handheld light microscope (Newton Nm1) with a mobile phone attachment to conventional light microscopy for the detection of Plasmodium falciparum in a cross-sectional study in rural Côte d'Ivoire. Single Giemsa-stained thick blood film from 223 individuals were prepared and read by local laboratory technicians on both microscopes under 1,000× magnification with oil. Of the 223 samples, 162 (72.6%) were P...
October 5, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27348755/accuracy-of-mobile-phone-and-handheld-light-microscopy-for-the-diagnosis-of-schistosomiasis-and-intestinal-protozoa-infections-in-c%C3%A3-te-d-ivoire
#16
Jean T Coulibaly, Mamadou Ouattara, Michael V D'Ambrosio, Daniel A Fletcher, Jennifer Keiser, Jürg Utzinger, Eliézer K N'Goran, Jason R Andrews, Isaac I Bogoch
BACKGROUND: Handheld light microscopy using compact optics and mobile phones may improve the quality of health care in resource-constrained settings by enabling access to prompt and accurate diagnosis. METHODOLOGY: Laboratory technicians were trained to operate two handheld diagnostic devices (Newton Nm1 microscope and a clip-on version of the mobile phone-based CellScope). The accuracy of these devices was compared to conventional light microscopy for the diagnosis of Schistosoma haematobium, S...
June 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27269913/the-moment-of-sale-treating-malaria-in-abidjan-c%C3%A3-te-d-ivoire
#17
Stefanie Granado, Brigit Obrist, Lenore Manderson, Marcel Tanner
Beyond home care without active treatment, the first step of home-based management of malaria (HMM) is the health provider-customer interactions that often lead to the purchase of drugs or herbs to treat symptoms. In Abidjan, Côte d'Ivoire, the quality and content of such interactions in pharmacies where antimalarials are sold officially, with illegal drug vendors and with herbal medicine sellers, vary considerably. Commercial encounters associated with adult illness episodes of locally identified malaria, observed in 2004-5, illustrate that customers present to sales points, on behalf of people who are ill, with a pre-established diagnosis and the intent of purchasing medication with which they have prior familiarity...
December 1, 2009: Anthropology & Medicine
https://www.readbyqxmd.com/read/27220440/-the-role-of-smoking-and-metabolic-enzyme-polymorphisms-in-the-organic-solvent-induced-chronic-encephalopathy
#18
H Y Wang, Y M Ma, J Z Cui, D Zhao, A J Liu, J Hong, Y G Lu, K J Wang
OBJECTIVE: The organic solvents and other exogenous compounds of metabolic enzymes genetic variation may affect the risk of the toxic effect of organic solvents exposure. Therefore, this research we observed the glutathione transferase M1 and T1 (GSTM1, GSTT1) deletion mutation genotype, two kinds of microsomal epoxide hydrolase (mEPHX) genetic polymorphism, organic solvents exposure and smoking effection in chronic cases of toxic encephalopathy (CTE) correlation. METHODS: The object was 115 patients who had a long history of organic solvents exposure, were divieded into two groups: CTE (n=83) , no CET (n=32) according to clinical diagnosis...
March 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27111824/a-clinical-approach-to-the-diagnosis-of-traumatic-encephalopathy-syndrome-a-review
#19
Nicole Reams, James T Eckner, Andrea A Almeida, Andrea L Aagesen, Bruno Giordani, Hank Paulson, Matthew T Lorincz, Jeffrey S Kutcher
IMPORTANCE: Chronic traumatic encephalopathy (CTE) refers to pathologic changes that have been found in some individuals with a history of repetitive traumatic impact to the head (hereinafter referred to as head trauma). These changes cannot be assessed during the clinical evaluation of a living patient. OBSERVATIONS: The neuropathologic features, taxonomy, history, role of biomarkers in diagnosis, and existing criteria of CTE are reviewed. Previous criteria have been proposed to approach the living patient; however, a unified, specific approach is needed for the practicing clinician...
June 1, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27070909/medical-imaging-in-small-bowel-crohn-s-disease-computer-tomography-enterography-magnetic-resonance-enterography-and-ultrasound-which-one-is-the-best-for-what
#20
REVIEW
Astrid-Jane Greenup, Brian Bressler, Greg Rosenfeld
BACKGROUND: Small bowel imaging in Crohn's disease (CD) is an important adjunct to endoscopy for the diagnosis, assessment of postoperative recurrence, and detection of complications. The best imaging modality for such indications though remains unclear. This systematic review aims to identify the imaging modality of choice considering the use of ultrasound (US), computed tomography enterography (CTE), and magnetic resonance enterography (MRE). METHODS: Databases were systematically searched for studies pertaining to the performance of US, CTE, and MRE, as compared with a predefined reference standard in the assessment of small bowel CD...
May 2016: Inflammatory Bowel Diseases
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