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https://www.readbyqxmd.com/read/28345872/intrinsically-stretchable-and-conductive-textile-by-a-scalable-process-for-elastic-wearable-electronics
#1
Chunya Wang, Mingchao Zhang, Kailun Xia, Xueqin Gong, Huimin Wang, Zhe Yin, Baolu Guan, Yingying Zhang
The prosperous development of stretchable electronics poses great demand in stretchable conductive materials which could maintain their electrical conductivity under tensile strain. Previously reported strategies to obtain stretchable conductors usually involve complex structure-fabricating processes or utilization of high-cost nanomaterials. It remains a great challenge to produce stretchable and conductive materials via a scalable and cost-effective process. A large-scalable pyrolysis strategy is developed for the fabrication of intrinsically stretchable and conductive textile utilizing low-cost and mass-produced weft-knitted textiles as raw materials...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28341461/sequential-therapy-of-anti-nogo-a-antibody-treatment-and-treadmill-training-leads-to-cumulative-improvements-after-spinal-cord-injury-in-rats
#2
Kinon Chen, Barnaby C Marsh, Matthew Cowan, Yazi D Al'Joboori, Sylvain Gigout, Calvin C Smith, Neil Messenger, Nikita Gamper, Martin E Schwab, Ronaldo M Ichiyama
Intense training is the most clinically successful treatment modality following incomplete spinal cord injuries (SCIs). With the advent of plasticity enhancing treatments, understanding how treatments might interact when delivered in combination becomes critical. Here, we investigated a rational approach to sequentially combine treadmill locomotor training with antibody mediated suppression of the fiber growth inhibitory protein Nogo-A. Following a large but incomplete thoracic lesion, rats were immediately treated with either anti-Nogo-A or control antibody (2weeks) and then either left untrained or step-trained starting 3weeks after injury for 8weeks...
March 21, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28339776/effect-of-acute-millimeter-wave-exposure-on-dopamine-metabolism-of-ngf-treated-pc12-cells
#3
Alexis J Haas, Yann Le Page, Maxim Zhadobov, Ronan Sauleau, Yves Le Dréan, Christian Saligaut
Several forthcoming wireless telecommunication systems will use electromagnetic frequencies at millimeter waves (MMWs), and technologies developed around the 60-GHz band will soon know a widespread distribution. Free nerve endings within the skin have been suggested to be the targets of MMW therapy which has been used in the former Soviet Union. So far, no studies have assessed the impact of MMW exposure on neuronal metabolism. Here, we investigated the effects of a 24-h MMW exposure at 60.4 GHz, with an incident power density (IPD) of 5 mW/cm², on the dopaminergic turnover of NGF-treated PC12 cells...
February 24, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28338059/non-thermal-air-plasma-promotes-the-healing-of-acute-skin-wounds-in-rats
#4
S Kubinova, K Zaviskova, L Uherkova, V Zablotskii, O Churpita, O Lunov, A Dejneka
Non-thermal plasma (NTP) has nonspecific antibacterial effects, and can be applied as an effective tool for the treatment of chronic wounds and other skin pathologies. In this study we analysed the effect of NTP on the healing of the full-thickness acute skin wound model in rats. We utilised a single jet NTP system generating atmospheric pressure air plasma, with ion volume density 5 · 10(17) m(-3) and gas temperature 30-35 °C. The skin wounds were exposed to three daily plasma treatments for 1 or 2 minutes and were evaluated 3, 7 and 14 days after the wounding by histological and gene expression analysis...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337129/novel-neuromodulation-techniques-to-assess-interhemispheric-communication-in-neural-injury-and-neurodegenerative-diseases
#5
REVIEW
Samuel S Shin, Galit Pelled
Interhemispheric interaction has a major role in various neurobehavioral functions. Its disruption is a major contributor to the pathological changes in the setting of brain injury such as traumatic brain injury, peripheral nerve injury, and stroke, as well as neurodegenerative diseases. Because interhemispheric interaction has a crucial role in functional consequence in these neuropathological states, a review of noninvasive and state-of-the-art molecular based neuromodulation methods that focus on or have the potential to elucidate interhemispheric interaction have been performed...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28336880/synthesis-of-carbon-nanotubes-in-thermal-plasma-reactor-at-atmospheric-pressure
#6
Lukasz Szymanski, Zbigniew Kolacinski, Slawomir Wiak, Grzegorz Raniszewski, Lukasz Pietrzak
In this paper, a novel approach to the synthesis of the carbon nanotubes (CNTs) in reactors operating at atmospheric pressure is presented. Based on the literature and our own research results, the most effective methods of CNT synthesis are investigated. Then, careful selection of reagents for the synthesis process is shown. Thanks to the performed calculations, an optimum composition of gases and the temperature for successful CNT synthesis in the CVD (chemical vapor deposition) process can be chosen. The results, having practical significance, may lead to an improvement of nanomaterials synthesis technology...
February 18, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28336550/the-effect-of-intravenous-corticotropin-releasing-hormone-administration-on-esophageal-sensitivity-and-motility-in-health
#7
Charlotte Broers, Chloé Melchior, Lukas Van Oudenhove, Tim Vanuytsel, Brecht Van Houtte, Charlotte Scheerens, Nathalie Rommel, Jan F Tack, Ans Pauwels
BACKGROUND: Esophageal hypersensitivity is important in gastro-esophageal reflux disease (GERD) patients refractory to acid-suppressive therapy. Stress affects visceral sensitivity and exacerbates heartburn in GERD. Peripheral CRH is a key mediator of the gut stress response. We hypothesize that CRH increases esophageal sensitivity and alters esophageal motility in health. METHODS: Esophageal sensitivity to thermal, mechanical, electrical and chemical stimuli was assessed in 14 healthy subjects after placebo or CRH (100μg IV)...
March 23, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28336375/tumortropic-adipose-derived-stem-cells-carrying-smart-nanotherapeutics-for-targeted-delivery-and-dual-modality-therapy-of-orthotopic-glioblastoma
#8
Wen-Chia Huang, I-Lin Lu, Wen-Hsuan Chiang, Yi-Wen Lin, Yuan-Chung Tsai, Hsin-Hung Chen, Chien-Wen Chang, Chi-Shiun Chiang, Hsin-Cheng Chiu
Chemotherapy is typically used to treat malignant brain tumors, especially for the tumors in surgically inaccessible areas. However, owing to the existence of blood-brain barrier (BBB), the tumor accumulation and therapeutic efficacy of clinical therapeutics is still of great concerns. To this end, we present herein a prominent therapeutic strategy adopting adipose-derived stem cells (ADSCs) capable of carrying nanotherapeutic payloads selectively toward brain tumors for thermo/chemotherapy. The nanoparticle (NP) payload was obtained from co-assembly of poly(γ-glutamic acid-co-distearyl γ-glutamate) with poly(lactic-co-glycolic acid), paclitaxel (PTX), and oleic acid-coated superparamagnetic iron oxide NPs in aqueous solution...
March 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28335204/multifunctional-inorganic-nanoparticles-recent-progress-in-thermal-therapy-and-imaging
#9
REVIEW
Kondareddy Cherukula, Kamali Manickavasagam Lekshmi, Saji Uthaman, Kihyun Cho, Chong-Su Cho, In-Kyu Park
Nanotechnology has enabled the development of many alternative anti-cancer approaches, such as thermal therapies, which cause minimal damage to healthy cells. Current challenges in cancer treatment are the identification of the diseased area and its efficient treatment without generating many side effects. Image-guided therapies can be a useful tool to diagnose and treat the diseased tissue and they offer therapy and imaging using a single nanostructure. The present review mainly focuses on recent advances in the field of thermal therapy and imaging integrated with multifunctional inorganic nanoparticles...
April 18, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28333640/integrated-hifu-drive-system-on-a-chip-for-cmut-based-catheter-ablation-system
#10
Omid Farhanieh, Ali Sahafi, Rupak Bardhan Roy, Arif Sanli Ergun, Ayhan Bozkurt
Conventional High Intensity Focused Ultrasound (HIFU) is a therapeutic modality which is extracorporeally administered. In applications where a relatively small HIFU lesion is required, an intravascular HIFU probe can be deployed to the ablation site. In this paper, we demonstrate the design and implementation a fully integrated HIFU drive system on a chip to be placed on a 6 Fr catheter probe. An 8-element capacitive micromachined ultrasound transducer (CMUT) ring array of 2 mm diameter has been used as the ultrasound source...
March 20, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28333145/the-cryo-thermal-therapy-eradicated-melanoma-in-mice-by-eliciting-cd4-t-cell-mediated-antitumor-memory-immune-response
#11
Kun He, Ping Liu, Lisa X Xu
Tumor metastasis is a major concern in tumor therapy. In our previous studies, a novel tumor therapeutic modality of the cryo-thermal therapy has been presented, highlighting its effect on the suppression of distal metastasis and leading to long-term survival in 4T1 murine mammary carcinoma model. To demonstrate the therapeutic efficacy in other aggressive tumor models and further investigate the mechanism of long-term survival induced, in this study, spontaneous metastatic murine B16F10 melanoma model was used...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28332669/multiple-imaging-and-excellent-anticancer-efficiency-of-an-upconverting-nanocarrier-mediated-by-single-near-infrared-light
#12
Yan Wang, Guixin Yang, Yanli Wang, Yanping Zhao, Haizhi Jiang, Yuyan Han, Piaoping Yang
It is difficult to meet the requirements of clinical diagnosis through a single imaging technique. Similarly, satisfactory therapy efficacy is also hard to achieve by a single therapeutic modality. It is therefore highly desirable and interesting to simultaneously achieve multimodal imaging and therapies in one single structure. In this study, we developed a core-shell-satellite NaGdF4:Yb,Er,Mn,Co@mSiO2-CuS structure using up-conversion luminescent (UCL) NaGdF4:Yb,Er,Mn,Co as the core, mesoporous silica as the layer, and the photoactive CuS nanoparticles as the satellites...
March 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28328287/photobiomodulation-with-non-thermal-lasers-mechanisms-of-action-and-therapeutic-uses-in-dermatology-and-aesthetic-medicine
#13
Mark Nestor, Anneke Andriessen, Brian Berman, Bruce E Katz, Dore Gilbert, David J Goldberg, Michael H Gold, Robert S Kirsner, Paul Z Lorenc
BACKGROUND: Non-thermal laser therapy in dermatology, is a growing field in medical technology by which therapeutic effects are achieved by exposing tissues to specific wavelengths of light. OBJECTIVES: The purpose of this review was to gain a better understanding of the science behind non-thermal laser and the evidence supporting its use in dermatology. METHODS: A group of dermatologists and surgeons recently convened to review the evidence supporting the use of non-thermal laser for body sculpting, improving the appearance of cellulite, and treating onychomycosis...
February 17, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28325093/differences-in-intracellular-mobile-zinc-levels-affect-susceptibility-to-plasma-activated-medium-induced-cytotoxicity
#14
Hirokazu Hara, Sayako Sueyoshi, Miko Taniguchi, Tetsuro Kamiya, Tetsuo Adachi
There is growing evidence that plasma-activated medium (PAM), which is prepared by non-thermal plasma (NTP) irradiation of cell-free medium, is a beneficial tool for cancer therapy. PAM has been reported to preferentially kill cancer cells; however, its mechanism is not fully understood. Since PAM contains reactive oxygen species (ROS) and reactive nitrogen species, the anti-cancer effects of PAM are thought to be attributed to oxidative stress induced by these reactive molecules. Oxidative stress has been shown to release zinc (Zn(2+)) from intracellular Zn(2+) stores and provoke Zn(2+)-dependent cell death...
March 21, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28324881/optic-radiation-tractography-and-visual-field-deficits-in-laser-interstitial-thermal-therapy-for-amygdalohippocampectomy-in-patients-with-mesial-temporal-lobe-epilepsy
#15
Dali Yin, John A Thompson, Cornelia Drees, Steven G Ojemann, Lidia Nagae, Victoria S Pelak, Aviva Abosch
BACKGROUND/AIMS: Laser interstitial thermal therapy (LITT) has become an alternative to open-resective surgery for refractory mesial temporal lobe epilepsy (MTLE). Occurrence of visual field defects (VFDs) following open surgery for MTLE is reported at 52-100%. We examined the rate of VFDs following LITT for amygdalohippocampectomy (AHE) and correlated the occurrence of VFDs with damage to the optic radiations, assessed by diffusion tensor tractography (DTI). METHODS: We performed a retrospective analysis of 5 patients who underwent LITT-AHE for medically refractory MTLE...
March 22, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28323500/strategies-to-target-glucose-metabolism-in-tumor-microenvironment-on-cancer-by-flavonoids
#16
Gang Wang, Jun-Jie Wang, Rui Guan, Li Du, Jing Gao, Xing-Li Fu
The imbalance between glucose metabolism and cancer cell growth in tumor microenvironment (TME), which are closely related with the occurrence and progression of cancer. Accumulating evidence has demonstrated that flavonoids exert many biological properties, including antioxidant and anticarcinogenic activities. Recently, the roles and applications of flavonoids, particularly in relation to glucose metabolism in cancers, have been highlighted. Thus, the identification of flavonoids targeting alternative glucose metabolism pathways in TME may represent an attractive approach to the more effective therapeutic strategies for cancer...
March 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28323405/oxygen-vacancy-enables-markedly-enhanced-magnetic-resonance-imaging-guided-photothermal-therapy-of-a-gd-3-doped-contrast-agent
#17
Dalong Ni, Jiawen Zhang, Jing Wang, Ping Hu, Yingying Jin, Zhongmin Tang, Zhenwei Yao, Wenbo Bu, Jianlin Shi
Gd(3+)-based contrast agents (CAs) are the most prevailing and widely used for enhanced magnetic resonance imaging (MRI). Numbers of approaches have been developed to regulate the key parameters in order to obtain high-relaxivity CAs, according to the classic Solomon-Bloembergen-Morgen theory. Herein, a method of controlling oxygen vacancies in inorganic nanosized CAs has been developed for largely accelerated proton relaxation to obtain a high r1 value. Such a strategy is verified on oxygen-deficient PEG-NaxGdWO3 nanorods, which exhibit a remarkable r1 value up to 80 mM(-1) s(-1) (at 0...
March 23, 2017: ACS Nano
https://www.readbyqxmd.com/read/28322140/applications-and-risks-of-nanomaterials-used-in-regenerative-medicine-delivery-systems-theranostics-and-therapy
#18
REVIEW
Estefany I Medina-Reyes, Danae Garcia-Viacobo, Franklin A Carrero-Martinez, Yolanda Irasema Chirino
Recent advances in nanotechnology have transformed the biomedicine field, in which the use of engineered nanomaterials (ENMs) has provided the foundation for novel applications. For this reason, the number of ENMs has increased rapidly, and here we provide a classification of ENMs based on chemical composition and biomedical applications, which include regenerative medicine, delivery systems, theranostics, and therapy. These have been identified as the most advanced and promising areas for further studies with humans...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/28317125/referenceless-magnetic-resonance-temperature-imaging-using-gaussian-process-modeling
#19
Joshua P Yung, David Fuentes, Christopher J MacLellan, Florian Maier, Yannis Liapis, John D Hazle, R Jason Stafford
PURPOSE: During magnetic resonance (MR)-guided thermal therapies, water proton resonance frequency shift (PRFS) based MR temperature imaging can quantitatively monitor tissue temperature changes. It is widely known that the PRFS technique is easily perturbed by tissue motion, tissue susceptibility changes, magnetic field drift, and modality-dependent applicator induced artifacts. Here a referenceless Gaussian process modeling (GPM) based estimation of the PRFS is investigated as a methodology to mitigate unwanted background field changes...
March 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28315267/pharmacological-modulation-of-the-sigma-1-receptor-and-the-treatment-of-pain
#20
Manuel Merlos, Javier Burgueño, Enrique Portillo-Salido, Carlos Ramón Plata-Salamán, José Miguel Vela
There is a critical need for new analgesics acting through new mechanisms of action, which could increase the efficacy with respect to existing therapies and reduce their unwanted effects. Current preclinical evidence supports the modulatory role of sigma-1 receptors (σ1R) in nociception, mainly based on the pain-attenuated phenotype of σ1R knockout mice and on the antinociceptive effect exerted by σ1R antagonists on pains of different etiologies. σ1R is highly expressed in different pain areas of the CNS and the periphery (particularly dorsal root ganglia), and interacts and modulates the functionality of different receptors and ion channels ...
2017: Advances in Experimental Medicine and Biology
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