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https://www.readbyqxmd.com/read/28538060/effect-of-low-level-laser-and-light-emitting-diode-on-inferior-alveolar-nerve-recovery-after-sagittal-split-osteotomy-of-the-mandible-a-randomized-clinical-trial-study
#1
Seyed Hasan Mohajerani, Faraj Tabeie, Mehdi Bemanali, Reza Tabrizi
PURPOSE: The major concern of sagittal split osteotomy (SSO) is the neurosensory disturbance. The authors investigated the effect of low-level laser therapy and light-emitting diode on the inferior alveolar nerve recovery after SSO. METHODS: In this double-blinded randomized clinical trial, 20 subjects with inferior alveolar nerve injury after SSO of the mandible were studied. Neurosensory recovery was assessed by 6 tests: visual analog scale (VAS), brush stroke, 2-point discrimination, contact detect detection, pinprick nociception, and thermal discrimination, and each one was performed before and after the surgery on days 1, 3, 7, 14, 60, and 180...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28533678/effect-of-thermal-pulsation-treatment-on-tear-film-parameters-in-dry-eye-disease-patients
#2
Michelle J Kim, Sandra S Stinnett, Preeya K Gupta
PURPOSE: The goal of this study was to evaluate the effect of thermal pulsation treatment on tear film parameters, specifically osmolarity and matrix metalloproteinase-9 (MMP-9), in patients with meibomian gland dysfunction (MGD) and dry eye disease (DED). METHODS: A single-center review of 189 eyes that underwent thermal pulsation treatment was performed. Data were collected on pre and posttreatment osmolarity, MMP-9, tear break-up time (TBUT), and ocular surface disease index (OSDI) score...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28531316/a-comprehensive-method-to-quantify-adaptations-by-male-and-female-mice-with-hot-flashes-induced-by-the-neurokinin-b-receptor-agonist-senktide
#3
Ashley A Krull, Sarah A Larsen, Donald K Clifton, Genevieve Neal-Perry, Robert A Steiner
Vasomotor symptoms (VMS, or hot flashes) plague millions of reproductive age men and women who have natural or iatrogenic loss of sex steroid production. Many affected individuals are left without treatment options because of contraindications to hormone replacement therapy and the lack of equally effective non-hormonal alternatives. Moreover, development of safer, more effective therapies has been stymied by the lack of an animal model that recapitulates the hot flash phenomenon and enables direct testing of hypotheses regarding the pathophysiology underlying hot flashes...
May 22, 2017: Endocrinology
https://www.readbyqxmd.com/read/28528668/trpv1-channels-in-immune-cells-and-hematological-malignancies
#4
Sofia A Omari, Murray J Adams, Dominic P Geraghty
Transient receptor potential vanilloid-1 (TRPV1) is a member of the TRP family of channels that are responsible for nociceptive, thermal, and mechanical sensations. Originally associated exclusively with sensory neurons, TRPV1 is now known to be present in almost all organs, including cells of the immune system, where TRPV1 has been shown to play a pivotal role in inflammation and immunity. Monocytes, macrophages, and dendritic cells express TRPV1, with both mouse and human studies suggesting that TRPV1 activation protects against endotoxin-induced inflammation...
2017: Advances in Pharmacology
https://www.readbyqxmd.com/read/28525890/a-novel-egfr-tki-inhibitor-camp-h3bo3%C3%A2-complex-combined-with-thermal-therapy-is-a-promising-strategy-to-improve-lung-cancer-treatment-outcomes
#5
Yongpeng Tong, Chunliu Huang, Junfang Zhang
PURPOSE: Although EGFR-TKIs (epidermal growth factor receptor tyrosine kinase inhibitors) induce favorable responses as first-line non-small cell lung cancer treatments, drug resistance remains a serious problem. Meanwhile, thermal therapy also shows promise as a cancer therapy strategy. Here we combine a novel EGFR-TKI treatment with thermal therapy to improve lung cancer treatment outcomes. RESULTS: The results suggest that the cAMP-H3BO3 complex effectively inhibits EGFR auto-phosphorylation, while inducing apoptosis and cell cycle arrest in vitro...
May 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28524663/polydopamine-generates-hydroxyl-free-radicals-under-uv-light-illumination
#6
Zehuan Wang, Feng Tang, Hailong Fan, Le Wang, Zhaoxia Jin
Polydopamine generally demonstrates as efficient free-radical scavenger. However, its free radical chemistry under illumination is unclear, which becomes important in view of growing studies of polydopamine applications in photoprotector and photothermal therapy. In this study, for the first time, we reported an experimental investigation of the generation of hydroxyl free-radicals from UV-illuminated polydopamine in aqueous environment. By using terephthalic acid as fluorescent probe, we have measured hydroxyl radicals generated from UV-illuminated polydopamine with different shapes and sizes...
May 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28521752/synthesis-characterization-and-biological-verification-of-anti-her2-indocyanine-green-doxorubicin-loaded-polyethyleneimine-coated-perfluorocarbon-double-nanoemulsions-for-targeted-photochemotherapy-of-breast-cancer-cells
#7
Yu-Hsiang Lee, Yun-Ting Ma
BACKGROUND: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females worldwide. Among various types of breast cancer, the human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer is known to be more aggressive and often resistant to medicinal treatment, leading to an insufficient prognosis and poor susceptibility to chemotherapy and/or hormonal therapy in the current clinic. These circumstances implicate that developing an improved therapeutic strategy rather than persistently changing the anticancer drugs for trying is truly needed to successfully cure this type of breast cancer...
May 18, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28515059/antibiotic-stability-over-six-weeks-in-aqueous-solution-at-body-temperature-with-and-without-heat-treatment-that-mimics-the-curing-of-bone-cement
#8
E Samara, T F Moriarty, L A Decosterd, R G Richards, E Gautier, P Wahl
OBJECTIVES: Thermal stability is a key property in determining the suitability of an antibiotic agent for local application in the treatment of orthopaedic infections. Despite the fact that long-term therapy is a stated goal of novel local delivery carriers, data describing thermal stability over a long period are scarce, and studies that avoid interference from specific carrier materials are absent from the orthopaedic literature. METHODS: In this study, a total of 38 frequently used antibiotic agents were maintained at 37°C in saline solution, and degradation and antibacterial activity assessed over six weeks...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28512549/evaluation-of-the-effectiveness-of-the-photobiomodulation-in-the-treatment-of-dentin-hypersensitivity-after-basic-therapy-a-randomized-clinical-trial
#9
Cristina García-Delaney, Daniel Abad-Sánchez, Josep Arnabat-Domínguez, Eduard Valmaseda-Castellón, Cosme Gay-Escoda
BACKGROUND: Dentin hypersensitivity (DH) in one of the most common causes of patient discomfort in the general population and its prevalence is higher in patients who have received basic or surgical periodontal treatment. Efficiency of the diode laser with different wavelengths has been studied by several authors, showing an improvement rate of the DH between 60-98%. The aim of the present study was to evaluate the effect of photobiomodulation (PBM) treatment on the reduction of DH after non surgical periodontal treatment...
May 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28511687/polymeric-micelles-with-dual-thermal-and-reactive-oxygen-species-ros-responsiveness-for-inflammatory-cancer-cell-delivery
#10
Meiqiong Tang, Ping Hu, Qiang Zheng, Nicola Tirelli, Xiaohong Yang, Zhanlong Wang, Yanfang Wang, Qing Tang, Yun He
BACKGROUND: The object of this study was to develop a thermally and reactive oxygen species-responsive nanocarrier system for cancer therapy. RESULTS: PPS-PNIPAm block copolymer was designed and synthesised using a combination of living anionic ring-opening polymerization and atom transfer radical polymerization. The synthesized polymer formed micellar aggregates in water and demonstrated dual responsiveness towards temperature and oxidants. Using doxorubicin (DOX) as a model drug, encapsulation and in vitro release of the drug molecules in PPS-PNIPAm nanocarriers confirmed the responsive release properties of such system...
May 16, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28502693/prolonged-blood-brain-barrier-disruption-following-laser-interstitial-ablation-in-epilepsy-a-case-series-with-a-case-report-of-post-ablation-optic-neuritis
#11
Saint-Aaron Morris, Matthew Rollo, Patrick Rollo, Jessica Johnson, Gerald A Grant, Elliott Friedman, Giridhar Kalamangalam, Nitin Tandon
OBJECTIVE: Laser interstitial thermal therapy (LITT) has become increasingly popular for targeting epileptic foci in a minimally invasive fashion. Despite its use in more than a thousand patients, the chronic effects of photo-thermal injury on brain physiology remain poorly understood. METHODS: We prospectively followed the clinical and radiographic courses of a cohort undergoing laser ablation for focal epilepsy. Only patients with non-enhancing lesions and those who had a delayed post-operative MRI with gadolinium administration approximately 6 months after the ablation were considered...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28497813/warming-the-mouse-to-model-human-diseases
#12
REVIEW
Kirthana Ganeshan, Ajay Chawla
Humans prefer to live within their thermal comfort or neutral zone, which they create by making shelters, wearing clothing and, more recently, by regulating their ambient temperature. These strategies enable humans to maintain a constant core temperature (a trait that is conserved across all endotherms, including mammals and birds) with minimal energy expenditure. Although this primordial drive leads us to seek thermal comfort, we house our experimental animals, laboratory mice (Mus musculus), under conditions of thermal stress...
May 12, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28496474/enhancement-of-antinociceptive-effect-by-co-administration-of-amitriptyline-and-crocus-sativus-in-a-rat-model-of-neuropathic-pain
#13
Bahareh Amin, Samira Hosseini, Hossein Hosseinzadeh
The aim of this study was to evaluate the anti-nociceptive effects of a low, sub-effective dose of amitriptyline, in combination with the different doses of ethanolic and aqueous extracts of Crocus sativus following sciatic nerve chronic constriction injury (CCI) in rats. Amitriptyline (3, 10 and 30 mg/Kg, i.p.) and the extracts (25, 50 and 100 mg/Kg, i.p.), were separately administered at the time of CCI for 7 consecutive days. In combination therapy, the sub-antinociceptive dose of amitriptyline (3 mg/Kg) was given with the three different doses of extracts for seven days...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28496166/measurement-of-local-temperature-increments-induced-by-cultured-hepg2-cells-with-micro-thermocouples-in-a-thermally-stabilized-system
#14
Fan Yang, Gang Li, Jiamin Yang, Zhenhai Wang, Danhong Han, Fengjie Zheng, Shengyong Xu
To monitor the temperature distribution of a cell and its changes under varied conditions is currently a technical challenge. A variety of non-contact methods used for measuring cellular temperature have been developed, where changes of local temperature at cell-level and sub-cell-level are indirectly calculated through the changes in intensity, band-shape, bandwidth, lifetime or polarization anisotropy of the fluorescence spectra recorded from the nano-sized fluorescent materials pre-injected into the target cell...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494610/paediatric-laser-dentistry-part-1-general-introduction
#15
C Caprioglio, G Olivi, M D Genovese
Knowledge of the physical characteristics of different laser lights and optical and thermal properties of oral tissues is very important to understand the interaction of dental lasers with biological tissues. Choosing the correct dental laser is crucial to match specific wavelengths with target chromophores of different tissues; this affinity makes laser irradiation selective and therefore minimally invasive. Various types of lasers are used in dentistry, offering a viable alternative to low and high-speed handpieces and surgical blades, and also minimising fear and discomfort of the patient...
March 2017: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28493544/recurrence-patterns-following-irreversible-electroporation-for-hepatic-malignancies
#16
Russell C Langan, Debra A Goldman, Michael I D'Angelica, Ronald P DeMatteo, Peter J Allen, Vinod P Balachandran, William R Jarnagin, T Peter Kingham
BACKGROUND: Irreversible electroporation (IRE) has emerged as a novel, safe ablative therapy for peri-vascular lesions. However, there remains a paucity of data on long-term outcomes. METHODS: We identified patients who underwent open IRE (1/2011-6/2015) for primary and secondary hepatic malignancies. Local ablation-zone recurrence (LR) was determined by cross-sectional imaging. Cumulative incidence (CumI) of LR was calculated and a competing risks regression assessed factors associated with LR...
May 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28492016/vaginal-rejuvenation-using-energy-based-devices
#17
REVIEW
Cheryl Karcher, Neil Sadick
Physiologic changes in a woman's life, such as childbirth, weight fluctuations, and hormonal changes due to aging and menopause, may alter the laxity of the vaginal canal, damage the pelvic floor, and devitalize the mucosal tone of the vaginal wall. These events often lead to the development of genitourinary conditions such as stress urinary incontinence; vaginal atrophy; dryness; and physiologic distress affecting a woman's quality of life, self-confidence, and sexuality. Various treatment modalities are currently available to manage these indications, varying from invasive vaginal surgery to more benign treatments like topical vaginal hormonal gels or hormone-replacement therapy...
September 2016: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28490907/perspective-on-the-rez%C3%A5-m-%C3%A2-system-a-minimally-invasive-treatment-strategy-for-benign-prostatic-hyperplasia-using-convective-radiofrequency-water-vapor-thermal-therapy
#18
Henry H Woo, Ricardo R Gonzalez
Convective radiofrequency (RF) water vapor thermal therapy is a minimally invasive office or outpatient procedure for the treatment of bothersome moderate-to-severe lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH). It provides an option for patients seeking rapid and durable relief of urinary symptoms, improved quality of life, and preservation of sexual function as an alternative to long-term use of drugs and avoidance of the potential side effects of pharmaceuticals or invasive BPH surgery...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/28490761/nanoscale-brownian-heating-by-interacting-magnetic-dipolar-particles
#19
Yann Chalopin, Jean-Claude Bacri, Florence Gazeau, Martin Devaud
Clusters of magnetic nanoparticles have received considerable interest in various research fields. Their capacity to generate heat under an alternating magnetic field has recently opened the way to applications such as cancer therapy by hyperthermia. This work is an attempt to investigate the collective effects of interacting dipoles embedded in magnetic nano-particles (MNP) to predict their thermal dissipation with a liquid. We first present a general approach, based on the tracking of the microscopic dipole fluctuations, to access to the dissipation spectra of any spatial distribution of MNPs...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28489530/real-time-3d-microwave-monitoring-of-interstitial-thermal-therapy
#20
Guanbo Chen, John Stang, Mark Haynes, Eric Leuthardt, Mahta Moghaddam
We report a method for real-time 3D monitoring of thermal therapy through the use of non-contact microwave imaging. This method is predicated on using microwaves to image changes in the dielectric properties of tissue with changing temperature. Instead of the precomputed linear Born approximation that was used in prior work to speed up the frameto- frame inversions, here we use the nonlinear Distorted Born Iterative Method (DBIM) to solve the electric volume integral equation to image the temperature change...
May 8, 2017: IEEE Transactions on Bio-medical Engineering
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