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diffusion tensor imaging and concussion

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https://www.readbyqxmd.com/read/27902865/small-world-properties-changes-in-mild-traumatic-brain-injury
#1
Yongxia Zhou
PURPOSE: To investigate local and global efficiency changes characterized by small-world properties based on resting-state functional MRI, such as centrality and clustering coefficient, in mild traumatic brain injury (MTBI) patients; and to associate these findings with axonal injury as measured by diffusion tensor imaging (DTI) as well as with post-concussive symptom (PCS). MATERIALS AND METHODS: Thirty patients (mean age 35 ± 13 years) with clinically defined MTBI and 45 age-matched healthy controls (mean age 37 ± 10 years) participated in the experiments...
November 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27893897/imaging-of-glial-cell-activation-and-white-matter-integrity-in-brains-of-active-and-recently-retired-national-football-league-players
#2
Jennifer M Coughlin, Yuchuan Wang, Il Minn, Nicholas Bienko, Emily B Ambinder, Xin Xu, Matthew E Peters, John W Dougherty, Melin Vranesic, Soo Min Koo, Hye-Hyun Ahn, Merton Lee, Chris Cottrell, Haris I Sair, Akira Sawa, Cynthia A Munro, Christopher J Nowinski, Robert F Dannals, Constantine G Lyketsos, Michael Kassiou, Gwenn Smith, Brian Caffo, Susumu Mori, Tomas R Guilarte, Martin G Pomper
Importance: Microglia, the resident immune cells of the central nervous system, play an important role in the brain's response to injury and neurodegenerative processes. It has been proposed that prolonged microglial activation occurs after single and repeated traumatic brain injury, possibly through sports-related concussive and subconcussive injuries. Limited in vivo brain imaging studies months to years after individuals experience a single moderate to severe traumatic brain injury suggest widespread persistent microglial activation, but there has been little study of persistent glial cell activity in brains of athletes with sports-related traumatic brain injury...
November 28, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27775478/subconcussive-head-impact-exposure-and-white-matter-tract-changes-over-a-single-season-of-youth-football
#3
Naeim Bahrami, Dev Sharma, Scott Rosenthal, Elizabeth M Davenport, Jillian E Urban, Benjamin Wagner, Youngkyoo Jung, Christopher G Vaughan, Gerard A Gioia, Joel D Stitzel, Christopher T Whitlow, Joseph A Maldjian
Purpose To examine the effects of subconcussive impacts resulting from a single season of youth (age range, 8-13 years) football on changes in specific white matter (WM) tracts as detected with diffusion-tensor imaging in the absence of clinically diagnosed concussions. Materials and Methods Head impact data were recorded by using the Head Impact Telemetry system and quantified as the combined-probability risk-weighted cumulative exposure (RWECP). Twenty-five male participants were evaluated for seasonal fractional anisotropy (FA) changes in specific WM tracts: the inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus, and superior longitudinal fasciculus (SLF)...
December 2016: Radiology
https://www.readbyqxmd.com/read/27698651/diffusion-tensor-imaging-findings-in-post-concussion-syndrome-patients-after-mild-traumatic-brain-injury-a-systematic-review
#4
Edrea Khong, Nicole Odenwald, Eyesha Hashim, Michael D Cusimano
OBJECTIVES: To review the evidence for the use of diffusion tensor imaging (DTI) parameters in the human brain as a diagnostic tool for and predictor of post-concussion syndrome (PCS) after a mild traumatic brain injury (mTBI). DESIGN: Systematic review. DATA SOURCES: All relevant studies in AMED, Embase, MEDLINE, Ovid, PubMed, Scopus, and Web of Science through 20 May, 2016. STUDY SELECTION: Studies that analyze traditional DTI measures [fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD)] and the severity of PCS symptoms or the development of PCS in humans after an mTBI...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27629984/compromised-neurocircuitry-in-chronic-blast-related-mild-traumatic-brain-injury
#5
Ping-Hong Yeh, Cheng Guan Koay, Binquan Wang, John Morissette, Elyssa Sham, Justin Senseney, David Joy, Alex Kubli, Chen-Haur Yeh, Victora Eskay, Wei Liu, Louis M French, Terrence R Oakes, Gerard Riedy, John Ollinger
The aim of this study was to apply recently developed automated fiber segmentation and quantification methods using diffusion tensor imaging (DTI) and DTI-based deterministic and probabilistic tractography to access local and global diffusion changes in blast-induced mild traumatic brain injury (bmTBI). Two hundred and two (202) male active US service members who reported persistent post-concussion symptoms for more than 6 months after injury were recruited. An additional forty (40) male military controls were included for comparison...
September 15, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27534259/alcohol-consumption-does-not-impede-recovery-from-mild-to-moderate-traumatic-brain-injury
#6
Noah D Silverberg, William Panenka, Grant L Iverson, Jeffrey R Brubacher, Jason R Shewchuk, Manraj K S Heran, Gary C S Oh, William G Honer, Rael T Lange
OBJECTIVES: To examine the effect of pre-injury alcohol use, acute alcohol intoxication, and post-injury alcohol use on outcome from mild to moderate traumatic brain injury (TBI). METHODS: Prospective inception cohort of patients who presented to the Emergency Department with mild to moderate TBI and had a blood alcohol level (BAL) taken for clinical purposes. Those who completed the 1-year outcome assessment were eligible for this study (N=91). Outcomes of interest were the count of post-concussion symptoms (British Columbia Post-Concussion Symptom Inventory), low neuropsychological test scores (Neuropsychological Assessment Battery), and abnormal regions of interest on diffusion tensor imaging (low fractional anisotropy)...
September 2016: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/27498246/brain-structure-alterations-and-cognitive-impairment-following-repetitive-mild-head-impact-an-in-vivo-mri-and-behavioral-study-in-rat
#7
Yang Qin, Gai-Li Li, Xian-Hua Xu, Zhi-Yong Sun, Jian-Wen Gu, Fa-Bao Gao
Mild traumatic brain injury (mTBI) or concussion is a common health issue. Several people repeatedly experience head impact milder than that causing concussion. The present study aimed to confirm the effects of such repeated impact on the brain structure and cognitive abilities. Rat models were established by closed skull weight-drop injury. The animals were anesthetized, subjected to single (s)-sham, s-mTBI, repetitive (r)-sham, and r-mTBI, and recovery times were recorded. MRI, including T2-weighted and diffusion tensor imaging (DTI), as well as, neurological severity scores (mNSS) were assessed for the dynamics of the brain structure and neurological function...
August 4, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27350072/novel-method-of-weighting-cumulative-helmet-impacts-improves-correlation-with-brain-white-matter-changes-after-one-football-season-of-sub-concussive-head-blows
#8
Kian Merchant-Borna, Patrick Asselin, Darren Narayan, Beau Abar, Courtney M C Jones, Jeffrey J Bazarian
One football season of sub-concussive head blows has been shown to be associated with subclinical white matter (WM) changes on diffusion tensor imaging (DTI). Prior research analyses of helmet-based impact metrics using mean and peak linear and rotational acceleration showed relatively weak correlations to these WM changes; however, these analyses failed to account for the emerging concept that neuronal vulnerability to successive hits is inversely related to the time between hits (TBH). To develop a novel method for quantifying the cumulative effects of sub-concussive head blows during a single season of collegiate football by weighting helmet-based impact measures for time between helmet impacts...
December 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27297660/white-matter-changes-and-confrontation-naming-in-retired-aging-nfl-athletes
#9
Jeremy F Strain, Nyaz Didehbani, Jeffrey Spence, Heather Conover, Elizabeth Bartz, Sethesh Mansinghani, Myrtle K Jeroudi, Neena K Rao, Lindy M Fields, Michael A Kraut, C Munro Cullum, John Hart, Kyle B Womack
Using diffusion tensor imaging (DTI), we assessed the relationship of white matter integrity and performance on the Boston Naming Test (BNT) in a group of retired professional football players and a control group. We examined correlations between fractional anisotropy (FA) and mean diffusivity (MD) with BNT T-scores in an unbiased voxel-wise analysis processed with tract-based spatial statistics (TBSS). We also analyzed the DTI data by grouping voxels together as white matter tracts and testing each tract's association with BNT T-scores...
June 13, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27237455/acute-white-matter-changes-following-sport-related-concussion-a-serial-diffusion-tensor-and-diffusion-kurtosis-tensor-imaging-study
#10
Melissa A Lancaster, Daniel V Olson, Michael A McCrea, Lindsay D Nelson, Ashley A LaRoche, L Tugan Muftuler
Recent neuroimaging studies have suggested that following sport-related concussion (SRC) physiological brain alterations may persist after an athlete has shown full symptom recovery. Diffusion MRI is a versatile technique to study white matter injury following SRC, yet serial follow-up studies in the very acute stages following SRC utilizing a comprehensive set of diffusion metrics are lacking. The aim of the current study was to characterize white matter changes within 24 hours of concussion in a group of high school and collegiate athletes, using Diffusion Tensor and Diffusion Kurtosis Tensor metrics...
May 30, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27138134/acute-white-matter-tract-damage-after-frontal-mild-traumatic-brain-injury
#11
Juan J Herrera, Kurt Bockhorst, Shakuntala Kondraganti, Laura Stertz, João Quevedo, Ponnada A Narayana
Our understanding of mild traumatic brain injury (mTBI) is still in its infancy and to gain a greater understanding, relevant animal models should replicate many of the features seen in human mTBI. These include changes to diffusion tensor imaging (DTI) parameters, absence of anatomical lesions on conventional neuroimaging, and neurobehavioral deficits. The Maryland closed head TBI model causes anterior-posterior plus sagittal rotational acceleration of the brain, frequently observed with motor vehicle and sports-related TBI injuries...
June 20, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/26834693/antisaccadic-eye-movements-are-correlated-with-corpus-callosum-white-matter-mean-diffusivity-stroop-performance-and-symptom-burden-in-mild-traumatic-brain-injury-and-concussion
#12
Windsor Kwan-Chun Ting, Tom A Schweizer, Jane Topolovec-Vranic, Michael D Cusimano
Antisaccades are thought to involve higher level inputs from neural centers involved in rapid eye movement inhibition and control. Previous work has demonstrated that performance on the antisaccade task can help in the assessment of injury in acute and/or chronic mild traumatic brain injury (mTBI). In this exploratory study, we performed cross-sectional and longitudinal comparisons of rapid eye movement, followed by correlations of antisaccade performance with assessments of symptom burden, diffusion tensor imaging, and a neuropsychological test of response inhibition...
2015: Frontiers in Neurology
https://www.readbyqxmd.com/read/26751097/traumatic-brain-injury-and-the-post-concussion-syndrome-a-diffusion-tensor-tractography-study
#13
Maria M D'souza, Richa Trivedi, Kavita Singh, Hemal Grover, Ajay Choudhury, Prabhjot Kaur, Pawan Kumar, Rajendra Prashad Tripathi
AIM: The aim of the present study is to evaluate diffusion tensor tractography (DTT) as a tool for detecting diffuse axonal injury in patients of acute, mild, and moderate traumatic brain injury (TBI), using two diffusion variables: Fractional anisotropy (FA) and mean diffusivity (MD). The correlation of these indices with the severity of post-concussive symptoms was also assessed. MATERIALS AND METHODS: Nineteen patients with acute, mild, or moderate TBI and twelve age- and sex-matched healthy controls were recruited...
October 2015: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/26724645/diffusion-mri-pitfalls-literature-review-and-future-directions-of-research-in-mild-traumatic-brain-injury
#14
REVIEW
Aurélie Delouche, Arnaud Attyé, Olivier Heck, Sylvie Grand, Adrian Kastler, Laurent Lamalle, Felix Renard, Alexandre Krainik
Mild traumatic brain injury (mTBI) is a leading cause of disability in adults, many of whom report a distressing combination of physical, emotional and cognitive symptoms, collectively known as post-concussion syndrome, that persist after the injury. Significant developments in magnetic resonance diffusion imaging, involving voxel-based quantitative analysis through the measurement of fractional anisotropy or mean diffusivity, have enhanced our knowledge on the different stages of mTBI pathophysiology. Other diffusion imaging-derived techniques, including diffusion kurtosis imaging with multi-shell diffusion and high-order tractography models, have recently demonstrated their usefulness in mTBI...
January 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/26684069/white-matter-alterations-in-youth-with-acute-mild-traumatic-brain-injury
#15
Lynn Babcock, Weihong Yuan, James Leach, Tiffany Nash, Shari Wade
PURPOSE: To examine acute alterations in white matter (WM) diffusion based on diffusion tensor imaging (DTI) in youth with mild traumatic brain injury (mTBI) relative to orthopedic injury (OI) controls. METHODS: A prospective cohort study of 23 patients with mTBI and 20 OI controls ages 11-16 years were recruited from the emergency department (ED). DTI was performed within 96 hours. Voxel based analysis quantified group differences for DTI indices: fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD)...
2015: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/26663463/longitudinal-assessment-of-white-matter-abnormalities-following-sports-related-concussion
#16
Timothy B Meier, Maurizio Bergamino, Patrick S F Bellgowan, T K Teague, Josef M Ling, Andreas Jeromin, Andrew R Mayer
There is great interest in developing physiological-based biomarkers such as diffusion tensor imaging to aid in the management of concussion, which is currently entirely dependent on clinical judgment. However, the time course for recovery of white matter abnormalities following sports-related concussion (SRC) is unknown. We collected diffusion tensor imaging and behavioral data in forty concussed collegiate athletes on average 1.64 days (T1; n = 33), 8.33 days (T2; n = 30), and 32.15 days post-concussion (T3; n = 26), with healthy collegiate contact-sport athletes (HA) serving as controls (n = 46)...
February 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/26414496/long-term-abnormalities-in-the-corpus-callosum-of-female-concussed-athletes
#17
Emilie Chamard, Genevieve Lefebvre, Maryse Lassonde, Hugo Theoret
Concussion is an injury affecting millions of individuals annually that can be associated with long-term sequelae. Recent studies have reported long-term abnormalities in the white matter (WM) tracts of male athletes. The corpus callosum (CC) and corticospinal tract (CST) have been shown to be particularly vulnerable to concussion, which may be related to abnormal interhemispheric functional connectivity and motor impairments. These anatomical pathways, however, have not been investigated in female athletes despite the functional significance of the CC and CST to adequate sports performance...
July 1, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/26412925/a-t1-and-dti-fused-3d-corpus-callosum-analysis-in-pre-vs-post-season-contact-sports-players
#18
Yi Lao, Meng Law, Jie Shi, Niharika Gajawelli, Lauren Haas, Yalin Wang, Natasha Leporé
Sports related traumatic brain injury (TBI) is a worldwide public health issue, and damage to the corpus callosum (CC) has been considered as an important indicator of TBI. However, contact sports players suffer repeated hits to the head during the course of a season even in the absence of diagnosed concussion, and less is known about their effect on callosal anatomy. In addition, T1-weighted and diffusion tensor brain magnetic resonance images (DTI) have been analyzed separately, but a joint analysis of both types of data may increase statistical power and give a more complete understanding of anatomical correlates of subclinical concussions in these athletes...
January 28, 2015: Proceedings of SPIE
https://www.readbyqxmd.com/read/26405087/principal-component-analysis-of-diffusion-tensor-images-to-determine-white-matter-injury-patterns-underlying-postconcussive-headache
#19
A Ghodadra, L Alhilali, S Fakhran
BACKGROUND AND PURPOSE: Principal component analysis, a data-reduction algorithm, generates a set of principal components that are independent, linear combinations of the original dataset. Our study sought to use principal component analysis of fractional anisotropy maps to identify white matter injury patterns that correlate with posttraumatic headache after mild traumatic brain injury. MATERIALS AND METHODS: Diffusion tensor imaging and neurocognitive testing with the Immediate Post-Concussion Assessment and Cognitive Test were performed in 40 patients with mild traumatic brain injury and 24 without posttraumatic headache...
February 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/26109715/clinical-and-imaging-assessment-of-acute-combat-mild-traumatic-brain-injury-in-afghanistan
#20
Octavian Adam, Christine L Mac Donald, Dennis Rivet, John Ritter, Todd May, Maria Barefield, Josh Duckworth, Donald LaBarge, Dean Asher, Benjamin Drinkwine, Yvette Woods, Michael Connor, David L Brody
OBJECTIVE: To evaluate whether diffusion tensor imaging (DTI) will noninvasively reveal white matter changes not present on conventional MRI in acute blast-related mild traumatic brain injury (mTBI) and to determine correlations with clinical measures and recovery. METHODS: Prospective observational study of 95 US military service members with mTBI enrolled within 7 days from injury in Afghanistan and 101 healthy controls. Assessments included Rivermead Post-Concussion Symptoms Questionnaire (RPCSQ), Post-Traumatic Stress Disorder Checklist Military (PCLM), Beck Depression Inventory (BDI), Balance Error Scoring System (BESS), Automated Neuropsychological Assessment Metrics (ANAM), conventional MRI, and DTI...
July 21, 2015: Neurology
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