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diffusion tensor imaging and concussion

Catherine D Chong, Todd J Schwedt
Even when concussions are associated with prolonged physical and cognitive sequelae, concussions are typically "invisible" on diagnostic brain imaging, indicating that the neuropathology associated with concussion lies under the detection threshold of routine imaging. However, data from brain structural and functional research imaging studies using diffusion tensor imaging, resting-state functional magnetic resonance imaging, and brain perfusion imaging indicate that these imaging sequences have a role in identifying concussion-related neuropathology...
February 24, 2018: Headache
Angela M Muller, Naznin Virji-Babul
Sports-related concussion in youth is a major public health issue. Evaluating the diffuse and often subtle changes in structure and function that occur in the brain, particularly in this population, remains a significant challenge. The goal of this pilot study was to evaluate the relationship between the intrinsic dynamics of the brain using resting-state functional magnetic resonance imaging (rs-fMRI) and relate these findings to structural brain correlates from diffusion tensor imaging in a group of adolescents with sports-related concussions ( n = 6) and a group of healthy adolescent athletes ( n = 6)...
January 2018: ASN Neuro
Meaghan Clough, Steven Mutimer, David K Wright, Adrian Tsang, Daniel M Costello, Andrew J Gardner, Peter Stanwell, Richelle Mychasiuk, Mujun Sun, Rhys D Brady, Stuart J McDonald, Kyria M Webster, Maddison R Johnstone, Bridgette D Semple, Denes V Agoston, Owen B White, Richard Frayne, Joanne Fielding, Terence J O'Brien, Sandy R Shultz
This study used oculomotor, cognitive, and multi-modal magnetic resonance imaging (MRI) measures to assess for neurological abnormalities in current asymptomatic amateur Australian rules footballers (i.e., Australia's most participated collision sport) with a history of sports-related concussion (SRC). Participants were 15 male amateur Australian rules football players with a history of SRC greater than 6 months previously, and 15 sex-, age-, and education-matched athlete control subjects that had no history of neurotrauma or participation in collision sports...
March 1, 2018: Journal of Neurotrauma
Eliana Bonfante, Roy Riascos, Octavio Arevalo
Conventional imaging findings in patients with cerebral concussion and chronic traumatic encephalopathy are absent or subtle in the majority of cases. The most common abnormalities include cerebral volume loss, enlargement of the cavum of the septum pellucidum, cerebral microhemorrhages, and white matter signal abnormalities, all of which have poor sensitivity and specificity. Advanced imaging modalities, such as diffusion tensor imaging (DTI), blood oxygen level dependent functional MR Imaging (BOLD fMRI), MR spectroscopy, perfusion imaging, positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetoencephalography detect physiologic abnormalities in symptomatic patients and, although currently in the investigation phase, may become useful in the clinical arena...
February 2018: Neuroimaging Clinics of North America
Sung Ho Jang, Young Hyeon Kwon
RATIONALE: We report on a patient who showed neural reorganization between injured cingula and the brainstem cholinergic nuclei following cerebral concussion. PATIENT CONCERNS: The main concern of the patient is memory impairment. DIAGNOSES: Cerebral concussion. OUTCOMES: When she visited our hospital at 2 years after onset, cognitive function was evaluated using 2 scales; the Wechsler Intelligence Scale, and the Seoul neuropsychological screening battery: total IQ 97, verbal immediate recall 5...
November 2017: Medicine (Baltimore)
Sigal Tal, Amir Hadanny, Efrat Sasson, Gil Suzin, Shai Efrati
Background: Recent clinical studies in stroke and traumatic brain injury (TBI) victims suffering chronic neurological injury present evidence that hyperbaric oxygen therapy (HBOT) can induce neuroplasticity. Objective: To assess the neurotherapeutic effect of HBOT on prolonged post-concussion syndrome (PPCS) due to TBI, using brain microstructure imaging. Methods: Fifteen patients afflicted with PPCS were treated with 60 daily HBOT sessions. Imaging evaluation was performed using Dynamic Susceptibility Contrast-Enhanced (DSC) and Diffusion Tensor Imaging (DTI) MR sequences...
2017: Frontiers in Human Neuroscience
Sourajit Mitra Mustafi, Jaroslaw Harezlak, Kevin M Koch, Andrew S Nencka, Timothy Meier, John D West, Christopher C Giza, John DiFiori, Kevin K Guskiewicz, Jason Mihalik, Stephen M LaConte, Stefan M Duma, Steven P Broglio, Andrew J Saykin, Michael McCrea, Thomas McAllister, Yu-Chien Wu
Sport-related concussion (SRC) is an important public health issue. While standardized assessment tools are useful in the clinical management of acute concussion, the underlying pathophysiology of SRC and the time course of physiological recovery after injury remain unclear. In this study, we used diffusion tensor imaging (DTI) to detect white-matter alterations in football players within 48 hours after SRC. As part of the NCAA-DoD CARE Consortium study of SRC, 30 American football players diagnosed with acute concussion, and 28 matched controls received clinical assessments and underwent advanced MRI scans...
October 25, 2017: Journal of Neurotrauma
Michael N Dretsch, Rael T Lange, Jeffery S Katz, Adam Goodman, Thomas A Daniel, Gopikrishna Deshpande, Thomas S Denney, Grant L Iverson, Jennifer L Robinson
BACKGROUND: There is a high comorbidity of posttraumatic stress (PTS) and mild traumatic brain injury (mTBI), with largely overlapping symptomatology, in military service members. OBJECTIVE: To examine white matter integrity associated with PTS and mTBI as assessed using diffusion tensor imaging (DTI). METHOD: Seventy-four active-duty U.S. soldiers with PTS (n = 16) and PTS with co-morbid history of mTBI (PTS/mTBI; n = 28) were compared to a military control group (n = 30)...
2017: Open Neuroimaging Journal
Pashtun Shahim, Laurena Holleran, Joong H Kim, David L Brody
We assessed the test-retest reliability of high spatial resolution diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI). Diffusion MRI was acquired using a Siemens 3 Tesla Prisma scanner with 80 mT/m gradients and a 32-channel head coil from each of 3 concussive traumatic brain injury (cTBI) patients and 4 controls twice 0 to 24 days apart. Coefficients of variation (CoV) for DTI parameters were calculated in each DTI Studio parcellated white matter tract at 1.25 mm and 1.75 mm isotropic voxel resolution, as well as DKI parameters at 1...
September 11, 2017: Scientific Reports
Nathan W Churchill, Michael G Hutchison, Alex P Di Battista, Simon J Graham, Tom A Schweizer
There is growing concern about how participation in contact sports affects the brain. Retrospective evidence suggests that contact sports are associated with long-term negative health outcomes. However, much of the research to date has focused on former athletes with significant health problems. Less is known about the health of current athletes in contact and collision sports who have not reported significant medical issues. In this cross-sectional study, advanced magnetic resonance imaging (MRI) was used to evaluate multiple aspects of brain physiology in three groups of athletes participating in non-contact sports (N = 20), contact sports (N = 22), and collision sports (N = 23)...
2017: Frontiers in Neurology
Nathan W Churchill, Michael G Hutchison, Doug Richards, General Leung, Simon J Graham, Tom A Schweizer
The medical decision of return to play (RTP) after a sport concussion is largely based on symptom status following a graded exercise protocol. However, it is currently unknown how objective markers of brain structure and function relate to clinical recovery. The goal of this study was to determine whether differences in brain structure and function at acute injury remain present at RTP. In this longitudinal study, 54 active varsity athletes were scanned using magnetic resonance imaging (MRI), including 27 with recent concussion, imaged at both acute injury and medical clearance, along with 27 matched controls...
August 24, 2017: Scientific Reports
Trevor Wu, Tricia L Merkley, Elisabeth A Wilde, Amanda Barnes, Xiaoqi Li, Zili David Chu, Stephen R McCauley, Jill V Hunter, Harvey S Levin
Diffusion tensor imaging (DTI) has demonstrated its utility in detecting microscopic post-concussion cerebral white matter structural changes, which are not routinely evident on conventional neuroimaging modalities. In this study, we compared 10 adolescents with sports concussion (SC) to 12 orthopedically-injured (OI) individuals within 96 h and three months post injury to 12 typically-developing (TD) participants using DTI and volumetric analyses. In terms of volume, no group differences were noted between SC, OI and TD groups at both 96 h and three months post concussion...
August 15, 2017: Brain Imaging and Behavior
Christian Lepage, Amicie de Pierrefeu, Inga K Koerte, Michael J Coleman, Ofer Pasternak, Gerald Grant, Christine E Marx, Rajendra A Morey, Laura A Flashman, Mark S George, Thomas W McAllister, Norberto Andaluz, Lori Shutter, Raul Coimbra, Ross D Zafonte, Murray B Stein, Martha E Shenton, Sylvain Bouix
Mild traumatic brain injuries (mTBIs) are often associated with posttraumatic stress disorder (PTSD). In cases of chronic mTBI, accurate diagnosis can be challenging due to the overlapping symptoms this condition shares with PTSD. Furthermore, mTBIs are heterogeneous and not easily observed using conventional neuroimaging tools, despite the fact that diffuse axonal injuries are the most common injury. Diffusion tensor imaging (DTI) is sensitive to diffuse axonal injuries and is thus more likely to detect mTBIs, especially when analyses account for the inter-individual variability of these injuries...
July 5, 2017: Brain Imaging and Behavior
Alexander W Thomas, Richard Watts, Christopher G Filippi, Joshua P Nickerson, Trevor Andrews, Gregory Lieberman, Magdalena R Naylor, Margaret J Eppstein, Kalev Freeman
The goal of this study was to investigate patterns of axonal injury in the first week after mild traumatic brain injury (mTBI). We performed a prospective cohort study of 20 patients presenting to the emergency department with mTBI, using 3.0T diffusion tensor MRI immediately after injury and again at 1 week post-injury. Corresponding data were acquired from 16 controls over a similar time interval. Fractional anisotropy (FA) and other diffusion measures were calculated from 11 a priori selected axon tracts at each time-point, and the change across time in each region was quantified for each subject...
2017: PloS One
Nathan W Churchill, Eduardo Caverzasi, Simon J Graham, Michael G Hutchison, Tom A Schweizer
Sport concussion is associated with disturbances in brain function in the absence of gross anatomical lesions, and may have long-term health consequences. Diffusion-weighted magnetic resonance imaging (MRI) methods provide a powerful tool for investigating alterations in white matter microstructure reflecting the long-term effects of concussion. In a previous study, diffusion tensor imaging (DTI) showed that athletes with a history of concussion had elevated fractional anisotropy (FA) and reduced mean diffusivity (MD) parameters...
May 29, 2017: Human Brain Mapping
Weihong Yuan, Shari L Wade, Catherine Quatman-Yates, Jason A Hugentobler, Paul J Gubanich, Brad G Kurowski
OBJECTIVE: To quantify structural connectivity abnormalities in adolescents with mild traumatic brain injury (mTBI) and to investigate connectivity changes following aerobic training using graph theory and diffusion tensor imaging tractography. SETTING: Outpatient research setting. PARTICIPANTS: Twenty-two children (age: 15.83 ± 1.77 years, 10 females) with 4 to 16 weeks of persistent symptoms after mTBI and a matched healthy comparison group...
November 2017: Journal of Head Trauma Rehabilitation
Ahmed Alnemari, Tarek R Mansour, Stephanie Gregory, Mark Buehler, Daniel Gaudin
No abstract text is available yet for this article.
May 11, 2017: Journal of Neurosurgical Sciences
Joshua Kamins, Erin Bigler, Tracey Covassin, Luke Henry, Simon Kemp, John J Leddy, Andrew Mayer, Michael McCrea, Mayumi Prins, Kathryn J Schneider, Tamara C Valovich McLeod, Roger Zemek, Christopher C Giza
AIM OR OBJECTIVE: The aim of this study is to consolidate studies of physiological measures following sport-related concussion (SRC) to determine if a time course of postinjury altered neurobiology can be outlined. This biological time course was considered with respect to clinically relevant outcomes such as vulnerability to repeat injury and safe timing of return to physical contact risk. DESIGN: Systematic review. DATA SOURCES: PubMed, CINAHL, Cochrane Central, PsychINFO...
June 2017: British Journal of Sports Medicine
Semyon M Slobounov, Alexa Walter, Hans C Breiter, David C Zhu, Xiaoxiao Bai, Tim Bream, Peter Seidenberg, Xianglun Mao, Brian Johnson, Thomas M Talavage
The cumulative effect of repetitive subconcussive collisions on the structural and functional integrity of the brain remains largely unknown. Athletes in collision sports, like football, experience a large number of impacts across a single season of play. The majority of these impacts, however, are generally overlooked, and their long-term consequences remain poorly understood. This study sought to examine the effects of repetitive collisions across a single competitive season in NCAA Football Bowl Subdivision athletes using advanced neuroimaging approaches...
2017: NeuroImage: Clinical
Breton Michael Asken, Steven T DeKosky, James R Clugston, Michael S Jaffee, Russell M Bauer
This review seeks to summarize diffusion tensor imaging (DTI) studies that have evaluated structural changes attributed to the mechanisms of mild traumatic brain injury (mTBI) in adult civilian, military, and athlete populations. Articles from 2002 to 2016 were retrieved from PubMed/MEDLINE, EBSCOhost, and Google Scholar, using a Boolean search string containing the following terms: "diffusion tensor imaging", "diffusion imaging", "DTI", "white matter", "concussion", "mild traumatic brain injury", "mTBI", "traumatic brain injury", and "TBI"...
March 24, 2017: Brain Imaging and Behavior
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