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DTI and Concussion

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https://www.readbyqxmd.com/read/27902865/small-world-properties-changes-in-mild-traumatic-brain-injury
#1
Yongxia Zhou
PURPOSE: To investigate local and global efficiency changes characterized by small-world properties based on resting-state functional MRI, such as centrality and clustering coefficient, in mild traumatic brain injury (MTBI) patients; and to associate these findings with axonal injury as measured by diffusion tensor imaging (DTI) as well as with post-concussive symptom (PCS). MATERIALS AND METHODS: Thirty patients (mean age 35 ± 13 years) with clinically defined MTBI and 45 age-matched healthy controls (mean age 37 ± 10 years) participated in the experiments...
November 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27812348/an-attempt-of-early-detection-of-poor-outcome-after-whiplash
#2
Sebastien Laporte, Danping Wang, Jennyfer Lecompte, Sophie Blancho, Baptiste Sandoz, Antoine Feydy, Pavel Lindberg, Julien Adrian, Elodie Chiarovano, Catherine de Waele, Pierre-Paul Vidal
The main concern with whiplash is that a large proportion of whiplash patients experience disabling symptoms or whiplash-associated disorders (WAD) for months if not years following the accident. Therefore, identifying early prognostic factors of WAD development is important as WAD have widespread clinical and economic consequences. In order to tackle that question, our study was specifically aimed at combining several methods of investigation in the same WAD patients at the acute stage and 6 months later...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27698651/diffusion-tensor-imaging-findings-in-post-concussion-syndrome-patients-after-mild-traumatic-brain-injury-a-systematic-review
#3
Edrea Khong, Nicole Odenwald, Eyesha Hashim, Michael D Cusimano
OBJECTIVES: To review the evidence for the use of diffusion tensor imaging (DTI) parameters in the human brain as a diagnostic tool for and predictor of post-concussion syndrome (PCS) after a mild traumatic brain injury (mTBI). DESIGN: Systematic review. DATA SOURCES: All relevant studies in AMED, Embase, MEDLINE, Ovid, PubMed, Scopus, and Web of Science through 20 May, 2016. STUDY SELECTION: Studies that analyze traditional DTI measures [fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD)] and the severity of PCS symptoms or the development of PCS in humans after an mTBI...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27629984/compromised-neurocircuitry-in-chronic-blast-related-mild-traumatic-brain-injury
#4
Ping-Hong Yeh, Cheng Guan Koay, Binquan Wang, John Morissette, Elyssa Sham, Justin Senseney, David Joy, Alex Kubli, Chen-Haur Yeh, Victora Eskay, Wei Liu, Louis M French, Terrence R Oakes, Gerard Riedy, John Ollinger
The aim of this study was to apply recently developed automated fiber segmentation and quantification methods using diffusion tensor imaging (DTI) and DTI-based deterministic and probabilistic tractography to access local and global diffusion changes in blast-induced mild traumatic brain injury (bmTBI). Two hundred and two (202) male active US service members who reported persistent post-concussion symptoms for more than 6 months after injury were recruited. An additional forty (40) male military controls were included for comparison...
September 15, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27498246/brain-structure-alterations-and-cognitive-impairment-following-repetitive-mild-head-impact-an-in-vivo-mri-and-behavioral-study-in-rat
#5
Yang Qin, Gai-Li Li, Xian-Hua Xu, Zhi-Yong Sun, Jian-Wen Gu, Fa-Bao Gao
Mild traumatic brain injury (mTBI) or concussion is a common health issue. Several people repeatedly experience head impact milder than that causing concussion. The present study aimed to confirm the effects of such repeated impact on the brain structure and cognitive abilities. Rat models were established by closed skull weight-drop injury. The animals were anesthetized, subjected to single (s)-sham, s-mTBI, repetitive (r)-sham, and r-mTBI, and recovery times were recorded. MRI, including T2-weighted and diffusion tensor imaging (DTI), as well as, neurological severity scores (mNSS) were assessed for the dynamics of the brain structure and neurological function...
August 4, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27350072/novel-method-of-weighting-cumulative-helmet-impacts-improves-correlation-with-brain-white-matter-changes-after-one-football-season-of-sub-concussive-head-blows
#6
Kian Merchant-Borna, Patrick Asselin, Darren Narayan, Beau Abar, Courtney M C Jones, Jeffrey J Bazarian
One football season of sub-concussive head blows has been shown to be associated with subclinical white matter (WM) changes on diffusion tensor imaging (DTI). Prior research analyses of helmet-based impact metrics using mean and peak linear and rotational acceleration showed relatively weak correlations to these WM changes; however, these analyses failed to account for the emerging concept that neuronal vulnerability to successive hits is inversely related to the time between hits (TBH). To develop a novel method for quantifying the cumulative effects of sub-concussive head blows during a single season of collegiate football by weighting helmet-based impact measures for time between helmet impacts...
December 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27297660/white-matter-changes-and-confrontation-naming-in-retired-aging-nfl-athletes
#7
Jeremy F Strain, Nyaz Didehbani, Jeffrey Spence, Heather Conover, Elizabeth Bartz, Sethesh Mansinghani, Myrtle K Jeroudi, Neena K Rao, Lindy M Fields, Michael A Kraut, C Munro Cullum, John Hart, Kyle B Womack
Using diffusion tensor imaging (DTI), we assessed the relationship of white matter integrity and performance on the Boston Naming Test (BNT) in a group of retired professional football players and a control group. We examined correlations between fractional anisotropy (FA) and mean diffusivity (MD) with BNT T-scores in an unbiased voxel-wise analysis processed with tract-based spatial statistics (TBSS). We also analyzed the DTI data by grouping voxels together as white matter tracts and testing each tract's association with BNT T-scores...
June 13, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27138134/acute-white-matter-tract-damage-after-frontal-mild-traumatic-brain-injury
#8
Juan J Herrera, Kurt Bockhorst, Shakuntala Kondraganti, Laura Stertz, João Quevedo, Ponnada A Narayana
Our understanding of mild traumatic brain injury (mTBI) is still in its infancy and to gain a greater understanding, relevant animal models should replicate many of the features seen in human mTBI. These include changes to diffusion tensor imaging (DTI) parameters, absence of anatomical lesions on conventional neuroimaging, and neurobehavioral deficits. The Maryland closed head TBI model causes anterior-posterior plus sagittal rotational acceleration of the brain, frequently observed with motor vehicle and sports-related TBI injuries...
June 20, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27042763/abnormalities-in-diffusional-kurtosis-metrics-related-to-head-impact-exposure-in-a-season-of-high-school-varsity-football
#9
Elizabeth M Davenport, Kalyna Apkarian, Christopher T Whitlow, Jillian E Urban, Jens H Jensen, Eliza Szuch, Mark A Espeland, Youngkyoo Jung, Daryl A Rosenbaum, Gerard A Gioia, Alexander K Powers, Joel D Stitzel, Joseph A Maldjian
The purpose of this study was to determine whether the effects of cumulative head impacts during a season of high school football produce changes in diffusional kurtosis imaging (DKI) metrics in the absence of clinically diagnosed concussion. Subjects were recruited from a high school football team and were outfitted with the Head Impact Telemetry System (HITS) during all practices and games. Biomechanical head impact exposure metrics were calculated, including: total impacts, summed acceleration, and Risk Weighted Cumulative Exposure (RWE)...
December 1, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/26903842/chronic-post-concussion-neurocognitive-deficits-i-relationship-with-white-matter-integrity
#10
Jun Maruta, Eva M Palacios, Robert D Zimmerman, Jamshid Ghajar, Pratik Mukherjee
We previously identified visual tracking deficits and associated degradation of integrity in specific white matter tracts as characteristics of concussion. We re-explored these characteristics in adult patients with persistent post-concussive symptoms using independent new data acquired during 2009-2012. Thirty-two patients and 126 normal controls underwent cognitive assessments and MR-DTI. After data collection, a subset of control subjects was selected to be individually paired with patients based on gender and age...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/26751097/traumatic-brain-injury-and-the-post-concussion-syndrome-a-diffusion-tensor-tractography-study
#11
Maria M D'souza, Richa Trivedi, Kavita Singh, Hemal Grover, Ajay Choudhury, Prabhjot Kaur, Pawan Kumar, Rajendra Prashad Tripathi
AIM: The aim of the present study is to evaluate diffusion tensor tractography (DTT) as a tool for detecting diffuse axonal injury in patients of acute, mild, and moderate traumatic brain injury (TBI), using two diffusion variables: Fractional anisotropy (FA) and mean diffusivity (MD). The correlation of these indices with the severity of post-concussive symptoms was also assessed. MATERIALS AND METHODS: Nineteen patients with acute, mild, or moderate TBI and twelve age- and sex-matched healthy controls were recruited...
October 2015: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/26684069/white-matter-alterations-in-youth-with-acute-mild-traumatic-brain-injury
#12
Lynn Babcock, Weihong Yuan, James Leach, Tiffany Nash, Shari Wade
PURPOSE: To examine acute alterations in white matter (WM) diffusion based on diffusion tensor imaging (DTI) in youth with mild traumatic brain injury (mTBI) relative to orthopedic injury (OI) controls. METHODS: A prospective cohort study of 23 patients with mTBI and 20 OI controls ages 11-16 years were recruited from the emergency department (ED). DTI was performed within 96 hours. Voxel based analysis quantified group differences for DTI indices: fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD)...
2015: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/26414496/long-term-abnormalities-in-the-corpus-callosum-of-female-concussed-athletes
#13
Emilie Chamard, Genevieve Lefebvre, Maryse Lassonde, Hugo Theoret
Concussion is an injury affecting millions of individuals annually that can be associated with long-term sequelae. Recent studies have reported long-term abnormalities in the white matter (WM) tracts of male athletes. The corpus callosum (CC) and corticospinal tract (CST) have been shown to be particularly vulnerable to concussion, which may be related to abnormal interhemispheric functional connectivity and motor impairments. These anatomical pathways, however, have not been investigated in female athletes despite the functional significance of the CC and CST to adequate sports performance...
July 1, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/26412925/a-t1-and-dti-fused-3d-corpus-callosum-analysis-in-pre-vs-post-season-contact-sports-players
#14
Yi Lao, Meng Law, Jie Shi, Niharika Gajawelli, Lauren Haas, Yalin Wang, Natasha Leporé
Sports related traumatic brain injury (TBI) is a worldwide public health issue, and damage to the corpus callosum (CC) has been considered as an important indicator of TBI. However, contact sports players suffer repeated hits to the head during the course of a season even in the absence of diagnosed concussion, and less is known about their effect on callosal anatomy. In addition, T1-weighted and diffusion tensor brain magnetic resonance images (DTI) have been analyzed separately, but a joint analysis of both types of data may increase statistical power and give a more complete understanding of anatomical correlates of subclinical concussions in these athletes...
January 28, 2015: Proceedings of SPIE
https://www.readbyqxmd.com/read/26405087/principal-component-analysis-of-diffusion-tensor-images-to-determine-white-matter-injury-patterns-underlying-postconcussive-headache
#15
A Ghodadra, L Alhilali, S Fakhran
BACKGROUND AND PURPOSE: Principal component analysis, a data-reduction algorithm, generates a set of principal components that are independent, linear combinations of the original dataset. Our study sought to use principal component analysis of fractional anisotropy maps to identify white matter injury patterns that correlate with posttraumatic headache after mild traumatic brain injury. MATERIALS AND METHODS: Diffusion tensor imaging and neurocognitive testing with the Immediate Post-Concussion Assessment and Cognitive Test were performed in 40 patients with mild traumatic brain injury and 24 without posttraumatic headache...
February 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/26109715/clinical-and-imaging-assessment-of-acute-combat-mild-traumatic-brain-injury-in-afghanistan
#16
Octavian Adam, Christine L Mac Donald, Dennis Rivet, John Ritter, Todd May, Maria Barefield, Josh Duckworth, Donald LaBarge, Dean Asher, Benjamin Drinkwine, Yvette Woods, Michael Connor, David L Brody
OBJECTIVE: To evaluate whether diffusion tensor imaging (DTI) will noninvasively reveal white matter changes not present on conventional MRI in acute blast-related mild traumatic brain injury (mTBI) and to determine correlations with clinical measures and recovery. METHODS: Prospective observational study of 95 US military service members with mTBI enrolled within 7 days from injury in Afghanistan and 101 healthy controls. Assessments included Rivermead Post-Concussion Symptoms Questionnaire (RPCSQ), Post-Traumatic Stress Disorder Checklist Military (PCLM), Beck Depression Inventory (BDI), Balance Error Scoring System (BESS), Automated Neuropsychological Assessment Metrics (ANAM), conventional MRI, and DTI...
July 21, 2015: Neurology
https://www.readbyqxmd.com/read/26109709/comment-does-brain-dti-mri-aid-diagnosis-of-battlefield-concussion
#17
COMMENT
Jack W Tsao
No abstract text is available yet for this article.
July 21, 2015: Neurology
https://www.readbyqxmd.com/read/25961592/dti-detection-of-longitudinal-wm-abnormalities-due-to-accumulated-head-impacts
#18
I Y Chun, X Mao, E L Breedlove, L J Leverenz, E A Nauman, T M Talavage
Longitudinal evaluation using diffusion-weighted imaging and collision event monitoring was performed on high school athletes who participate in American football. Observed changes in white matter health were suggestive of injury and found to be correlated with accumulation of head collision events during practices and games.
2015: Developmental Neuropsychology
https://www.readbyqxmd.com/read/25915776/neuropsychological-outcome-and-diffusion-tensor-imaging-in-complicated-versus-uncomplicated-mild-traumatic-brain-injury
#19
William J Panenka, Rael T Lange, Sylvain Bouix, Jason R Shewchuk, Manraj K S Heran, Jeffrey R Brubacher, Ryan Eckbo, Martha E Shenton, Grant L Iverson
This study examined whether intracranial neuroimaging abnormalities in those with mild traumatic brain injury (MTBI) (i.e., "complicated" MTBIs) are associated with worse subacute outcomes as measured by cognitive testing, symptom ratings, and/or diffusion tensor imaging (DTI). We hypothesized that (i) as a group, participants with complicated MTBIs would report greater symptoms and have worse neurocognitive outcomes than those with uncomplicated MTBI, and (ii) as a group, participants with complicated MTBIs would show more Diffusion Tensor Imaging (DTI) abnormalities...
2015: PloS One
https://www.readbyqxmd.com/read/25795157/white-matter-damage-and-brain-network-alterations-in-concussed-patients-a-review-of-recent-diffusion-tensor-imaging-and-resting-state-functional-connectivity-data
#20
REVIEW
Catherine D Chong, Todd J Schwedt
Over 2 million people are diagnosed with concussion each year in the USA, resulting in substantial individual and societal burdens. Although 'routine' clinical neuroimaging is useful for the diagnosis of more severe forms of traumatic brain injury, it is insensitive for detecting pathology associated with concussion. Diffusion tensor imaging (DTI) and blood-oxygenation-level-dependent (BOLD) resting-state functional connectivity magnetic resonance imaging (rs-fMRI) are techniques that allow for investigation of brain structural and functional connectivity patterns...
May 2015: Current Pain and Headache Reports
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