keyword
https://read.qxmd.com/read/38530595/female-cerebellum-seems-sociable-an-itbs-investigation
#1
JOURNAL ARTICLE
Fereshteh Kavandi Ghezeljeh, Reza Kazemi, Reza Rostami, Ahmad Zandbagleh, Sanaz Khomami, Fatemeh Rostam Vandi, Abed L Hadipour
The cerebellum has been shown to be engaged in tasks other than motor control, including cognitive and affective functions. Prior neuroimaging studies have documented the role of this area in social cognition and despite these findings, no studies have yet examined the causal relationship between the cerebellum and social cognition. This study aimed to investigate the role of the cerebellum in empathy and theory of mind (ToM) in a randomized, placebo-controlled, double-blind, parallel study. 32 healthy participants were assigned to either a sham or active group...
March 26, 2024: Cerebellum
https://read.qxmd.com/read/38530297/intensity-and-frequency-specific-effects-of-transcranial-alternating-current-stimulation-are-explained-by-network-dynamics
#2
JOURNAL ARTICLE
Zhihe Zhao, Sina Shirinpour, Harry Tran, Miles Wischnewski, Alexander Opitz
Transcranial alternating current stimulation (tACS) can be used to non-invasively entrain neural activity, and thereby cause changes in local neural oscillatory power. Despite an increased use in cognitive and clinical neuroscience, the fundamental mechanisms of tACS are still not fully understood.
Approach. We developed a computational neuronal network model of two-compartment pyramidal neurons and inhibitory interneurons which mimic the local cortical circuits. We modeled tACS with electric field strengths that are achievable in human applications...
March 26, 2024: Journal of Neural Engineering
https://read.qxmd.com/read/38529862/-neurometabolic-therapy-of-mild-cognitive-impairment-in-patients-with-chronic-cerebral-ischemia
#3
JOURNAL ARTICLE
E A Antipenko, A V Shulyndin, K M Belyakov
OBJECTIVE: To evaluate the effect of a sequential therapy regimen with Mexidol (500 mg injections intravenously for 14 days) and Mexidol FORTE 250 (250 mg tablets 3 times a day for 60 days) on higher cortical functions in patients with moderate cognitive disorders in chronic cerebral ischemia. MATERIAL AND METHODS: A comparative, prospective study included 63 patients with chronic cerebral ischemia with moderate cognitive impairment. All patients received basic therapy aimed at reducing risk factors (antihypertensive, antithrombotic drugs as indicated)...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38529503/recurrent-activity-within-microcircuits-of-macaque-dorsolateral-prefrontal-cortex-tracks-cognitive-flexibility
#4
Suzanne O Nolan, Patrick R Melugin, Kirsty R Erickson, Wilson R Adams, Zahra Z Farahbakhsh, Colleen E Mcgonigle, Michelle H Kwon, Vincent D Costa, Christopher C Lapish, Troy A Hackett, Verginia C Cuzon Carlson, Christos Constantinidis, Kathleen A Grant, Cody A Siciliano
Human and non-human primate data clearly implicate the dorsolateral prefrontal cortex (dlPFC) as critical for advanced cognitive functions 1,2 . It is thought that intracortical synaptic architectures within dlPFC are the integral neurobiological substrate that gives rise to these processes, including working memory, inferential reasoning, and decision-making 3-7 . In the prevailing model, each cortical column makes up one fundamental processing unit composed of dense intrinsic connectivity, conceptualized as the 'canonical' cortical microcircuit 3,8 ...
September 24, 2023: bioRxiv
https://read.qxmd.com/read/38529036/clinical-presentation-and-diagnosis-of-adult-onset-leukoencephalopathy-with-axonal-spheroids-and-pigmented-glia-a-literature-analysis-of-case-studies
#5
JOURNAL ARTICLE
Spyros Papapetropoulos, Jeffrey M Gelfand, Takuya Konno, Takeshi Ikeuchi, Angela Pontius, Andreas Meier, Farid Foroutan, Zbigniew K Wszolek
INTRODUCTION: Because adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare, rapidly progressive, debilitating, and ultimately fatal neurodegenerative disease, a rapid and accurate diagnosis is critical. This analysis examined the frequency of initial misdiagnosis of ALSP via comprehensive review of peer-reviewed published cases. METHODS: Data were extracted from a MEDLINE search via PubMed (January 1, 1980, through March 22, 2022) from eligible published case reports/series for patients with an ALSP diagnosis that had been confirmed by testing for the colony-stimulating factor-1 receptor gene ( CSF1R ) mutation...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38527593/hippocampal-hdac6-promotes-pocd-by-regulating-nlrp3-induced-microglia-pyroptosis-via-hsp90-hsp70-in-aged-mice
#6
JOURNAL ARTICLE
Qi-Cheng Lin, Jiao Wang, Xin-Lin Wang, Chi Pan, Shao-Wu Jin, Steven Char, Yuan-Xiang Tao, Hong Cao, Jun Li
BACKGROUND: Postoperative Cognitive Dysfunction (POCD) has attracted increased attention, but its precise mechanism remains to be explored. This study aimed to figure out whether HDAC6 could regulate NLRP3-induced pyroptosis by modulating the functions of HSP70 and HSP90 in microglia to participate in postoperative cognitive dysfunction in aged mice. METHODS: Animal models of postoperative cognitive dysfunction in aged mice were established by splenectomy under sevoflurane anesthesia...
March 23, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38527078/from-motion-to-emotion-visual-pathways-and-potential-interconnections
#7
JOURNAL ARTICLE
Aina Puce
The two visual pathway description of [Ungerleider, L. G., & Mishkin, M. Two cortical visual systems. In D. J. Dingle, M. A. Goodale, & R. J. W. Mansfield (Eds.), Analysis of visual behavior (pp. 549-586). Cambridge, MA: MIT, 1982] changed the course of late 20th century systems and cognitive neuroscience. Here, I try to reexamine our laboratory's work through the lens of the [Pitcher, D., & Ungerleider, L. G. Evidence for a third visual pathway specialized for social perception. Trends in Cognitive Sciences, 25, 100-110, 2021] new third visual pathway...
March 22, 2024: Journal of Cognitive Neuroscience
https://read.qxmd.com/read/38526943/effects-of-finger-pinch-motor-imagery-on-short-latency-afferent-inhibition-and-corticospinal-excitability
#8
JOURNAL ARTICLE
Kento Nakashoji, Atsushi Sasaki, Naotsugu Kaneko, Taishin Nomura, Matija Milosevic
Motor imagery is a cognitive process involving the simulation of motor actions without actual movements. Despite the reported positive effects of motor imagery training on motor function, the underlying neurophysiological mechanisms have yet to be fully elucidated. Therefore, the purpose of the present study was to investigate how sustained tonic finger-pinching motor imagery modulates sensorimotor integration and corticospinal excitability using short-latency afferent inhibition (SAI) and single-pulse transcranial magnetic stimulation (TMS) assessments, respectively...
March 8, 2024: Neuroreport
https://read.qxmd.com/read/38525592/udp-glucose-p2y14-receptor-signaling-exacerbates-neuronal-apoptosis-after-subarachnoid-hemorrhage-in-rats
#9
JOURNAL ARTICLE
Hideki Kanamaru, Shiyi Zhu, Siyuan Dong, Yushin Takemoto, Lei Huang, Prativa Sherchan, Hidenori Suzuki, Jiping Tang, John H Zhang
BACKGROUND: Subarachnoid hemorrhage (SAH) is a severe subtype of stroke with poor outcomes. Abnormal glucose metabolism often occurs after SAH, but the strict control of blood glucose levels is not always beneficial. This study aimed to investigate the contribution of uridine diphosphate glucose (UDP-G), an intermediate of glucose/glycogen metabolism, and its receptor P2Y14 (P2Y purinoceptor 14) to SAH pathology and explored the potential targeted treatments in rats. METHODS: A total of 218 Sprague-Dawley male rats were used...
March 25, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38522385/childhood-engagement-in-cognitively-stimulating-activities-moderates-relationships-between-brain-structure-and-cognitive-function-in-adulthood
#10
JOURNAL ARTICLE
Alexandra M Gaynor, Yunglin Gazes, Caleb R Haynes, Reshma S Babukutty, Christian Habeck, Yaakov Stern, Yian Gu
Greater engagement in cognitively stimulating activities (CSA) during adulthood has been shown to protect against neurocognitive decline, but no studies have investigated whether CSA during childhood protects against effects of brain changes on cognition later in life. The current study tested the moderating role of childhood CSA in the relationships between brain structure and cognitive performance during adulthood. At baseline (N=250) and 5-year follow-up (N=204) healthy adults aged 20-80 underwent MRI to assess four structural brain measures and completed neuropsychological tests to measure three cognitive domains...
February 23, 2024: Neurobiology of Aging
https://read.qxmd.com/read/38522079/transcranial-random-noise-stimulation-in-the-management-of-cognitive-and-behavioral-symptoms-in-a-suicidal-hanging-survivor-a-case-study
#11
JOURNAL ARTICLE
Sujita Kumar Kar, Rahul Prajapati, Vikas Bharti, Sanjana Bhasin, Priyanshi Chaudhary, Devika Raje
No abstract text is available yet for this article.
March 21, 2024: Journal of ECT
https://read.qxmd.com/read/38520640/intraoperative-mapping-and-preservation-of-executive-functions-in-awake-craniotomy-a-systematic-review
#12
REVIEW
Rabeet Tariq, Hafiza Fatima Aziz, Shahier Paracha, Noman Ahmed, Muhammad Waqas Saeed Baqai, Saqib Kamran Bakhshi, Annabel McAtee, Timothy J Ainger, Farhan A Mirza, Syed Ather Enam
Awake craniotomy (AC) allows intraoperative brain mapping (ioBM) for maximum lesion resection while monitoring and preserving neurological function. Conventionally, language, visuospatial assessment, and motor functions are mapped, while the assessment of executive functions (EF) is uncommon. Impaired EF may lead to occupational, personal, and social limitations, thus, a compromised quality of life. A comprehensive literature search was conducted through Scopus, Medline, and Cochrane Library using a pre-defined search strategy...
March 23, 2024: Neurological Sciences
https://read.qxmd.com/read/38518928/fused-thiophene-as-a-privileged-scaffold-a-review-on-anti-alzheimer-s-disease-potentials-via-targeting-cholinesterases-monoamine-oxidases-glycogen-synthase-kinase-3-and-a%C3%AE-aggregation
#13
REVIEW
Asmaa E Kassab, Ehab M Gedawy, Alaa S Sayed
As a "silent threat," Alzheimer's disease (AD) is quickly rising to the top of the list of costly and troublesome diseases facing humanity. It is growing to be one of the most troublesome and expensive conditions, with annual health care costs higher than those of cancer and comparable to those of cardiovascular disorders. One of the main pathogenic characteristics of AD is the deficiency of the neurotransmitter acetylcholine (ACh) which plays a vital role in memory, learning, and attention. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) play a crucial role in hydrolyzing ACh...
March 20, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38517175/effects-of-accelerated-intermittent-theta-burst-stimulation-in-modulating-brain-of-alzheimer-s-disease
#14
JOURNAL ARTICLE
Hua Lin, Junhua Liang, Qianqian Wang, Yuxuan Shao, Penghui Song, Siran Li, Yang Bai
Intermittent theta-burst stimulation (iTBS) is emerging as a noninvasive therapeutic strategy for Alzheimer's disease (AD). Recent advances highlighted a new accelerated iTBS (aiTBS) protocol, consisting of multiple sessions per day and higher overall pulse doses, in brain modulation. To examine the possibility of applying the aiTBS in treating AD patients, we enrolled 45 patients in AD at early clinical stages, and they were randomly assigned to either receive real or sham aiTBS. Neuropsychological scores were evaluated before and after treatment...
March 1, 2024: Cerebral Cortex
https://read.qxmd.com/read/38516831/activation-of-sting-signaling-aggravates-chronic-alcohol-exposure-induced-cognitive-impairment-by-increasing-neuroinflammation-and-mitochondrial-apoptosis
#15
JOURNAL ARTICLE
Xinrou Lin, Xiangpen Li, Chenguang Li, Hongxuan Wang, Lubin Zou, Jingrui Pan, Xiaoni Zhang, Lei He, Xiaoming Rong, Ying Peng
AIMS: Chronic alcohol exposure leads to persistent neurological disorders, which are mainly attributed to neuroinflammation and apoptosis. Stimulator of IFN genes (STING) is essential in the cytosolic DNA sensing pathway and is involved in inflammation and cellular death processes. This study was to examine the expression pattern and biological functions of STING signaling in alcohol use disorder (AUD). METHODS: Cell-free DNA was extracted from human and mouse plasma...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38515977/human-values-civic-participation-and-wellbeing-analysis-on-their-relationship-among-older-europeans
#16
JOURNAL ARTICLE
Andrea Vega-Tinoco, Julia Sánchez-García, Marta Gil-Lacruz, María José Sierra Berdejo, Ana Isabel Gil-Lacruz
INTRODUCTION: So far, both for the general and older population, research on human values and wellbeing mainly shows correlational associations but does not inquire about the direction of this relationship. This is also true for values and civic participation. Therefore, our objective is to identify the directional association between civic participation and Schwartz values, and between values and wellbeing, among older Europeans. METHODS: A pseudo-panel was created from the cross-sectional data of the European Social Survey (ESS 2002-2018), controlling for gender, age-group, country and level of studies ( n = 3926)...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38515789/glitches-in-the-brain-the-dangerous-relationship-between-radiotherapy-and-brain-fog
#17
REVIEW
Noemi Marino, Martina Bedeschi, Melania Elettra Vaccari, Marco Cambiaghi, Anna Tesei
Up to approximately 70% of cancer survivors report persistent deficits in memory, attention, speed of information processing, multi-tasking, and mental health functioning, a series of symptoms known as "brain fog." The severity and duration of such effects can vary depending on age, cancer type, and treatment regimens. In particular, every year, hundreds of thousands of patients worldwide undergo radiotherapy (RT) for primary brain tumors and brain metastases originating from extracranial tumors. Besides its potential benefits in the control of tumor progression, recent studies indicate that RT reprograms the brain tumor microenvironment inducing increased activation of microglia and astrocytes and a consequent general condition of neuroinflammation that in case it becomes chronic could lead to a cognitive decline...
2024: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38515445/safety-tolerability-and-efficacy-estimate-of-evoked-gamma-oscillation-in-mild-to-moderate-alzheimer-s-disease
#18
JOURNAL ARTICLE
Mihály Hajós, Alyssa Boasso, Evan Hempel, Monika Shpokayte, Alex Konisky, Chandran V Seshagiri, Vitella Fomenko, Kim Kwan, Jessie Nicodemus-Johnson, Suzanne Hendrix, Brent Vaughan, Ralph Kern, Jonathan T Megerian, Zach Malchano
BACKGROUND: Alzheimer's Disease (AD) is a multifactorial, progressive neurodegenerative disease that disrupts synaptic and neuronal activity and network oscillations. It is characterized by neuronal loss, brain atrophy and a decline in cognitive and functional abilities. Cognito's Evoked Gamma Therapy System provides an innovative approach for AD by inducing EEG-verified gamma oscillations through sensory stimulation. Prior research has shown promising disease-modifying effects in experimental AD models...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38515262/the-expectations-and-experiences-of-patients-regarding-the-diagnostic-workup-at-a-specialized-memory-clinic-an-interview-study
#19
JOURNAL ARTICLE
Malin Aspö, Maria Sundell, Myroslava Protsiv, Fleur Wiggenraad, Marie Rydén, Francesca Mangialasche, Miia Kivipelto, Leonie N C Visser
BACKGROUND: Because of the shift towards earlier diagnosis of dementia and/or Alzheimer's disease (AD), increasing numbers of individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI) are seen in memory clinics. Yet, evidence indicates that there is room for improvement when it comes to tailoring of the diagnostic work-up to the needs of individual patients. To optimize the quality of care, we explored patients' perspectives regarding the diagnostic work-up at a specialized memory clinic...
April 2024: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://read.qxmd.com/read/38512529/efficacy-of-rtms-in-treating-functional-impairment-in-post-stroke-patients-a-systematic-review-and-meta-analysis
#20
JOURNAL ARTICLE
Xiaodong Duan, Delong Huang, Haoshu Zhong, Junhao Wu, Zhihan Xiao, Peng Yang, Yuanhang Han, Haodong Jiang, Ping Zhou, Xi Liu
BACKGROUND: Most stroke patients suffer from an imbalance in blood supply, which causes severe brain damage leading to functional deficits in motor, sensory, swallowing, cognitive, emotional, and speech functions. Repetitive transcranial magnetic stimulation (rTMS) is thought to restore functions impaired during the stroke process and improve the quality of life of stroke patients. However, the efficacy of rTMS in treating post-stroke function impairment varies significantly. Therefore, we conducted a meta-analysis of the number of patients with effective rTMS in treating post-stroke dysfunction...
March 21, 2024: Neurological Sciences
keyword
keyword
115411
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.