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JOURNAL ARTICLE
Expanding MAPT p.V363I Mutation Phenotype: An Overlapping of PSP-CBS and Posterior Cortical Atrophy.
Jacy Bezerra Parmera, Artur Martins Coutinho, Thiago Gonçalves Guimarães, Joyce Yuri Silvestre Yamamoto, Leonel Tadao Takada, Ricardo Nitrini, Egberto Reis Barbosa, Sonia Maria Dozzi Brucki
No abstract text is available yet for this article.
April 2023: Movement Disorders Clinical Practice
#22
JOURNAL ARTICLE
L L de Godoy, A Studart-Neto, D R de Paula, N Green, A Halder, P Arantes, K T Chaim, N C Moraes, M S Yassuda, R Nitrini, M Dresler, C da Costa Leite, J Panovska-Griffiths, A Soddu, S Bisdas
BACKGROUND AND PURPOSE: Superagers are defined as older adults with episodic memory performance similar or superior to that in middle-aged adults. This study aimed to investigate the key differences in discriminative networks and their main nodes between superagers and cognitively average elderly controls. In addition, we sought to explore differences in sensitivity in detecting these functional activities across the networks at 3T and 7T MR imaging fields. MATERIALS AND METHODS: Fifty-five subjects 80 years of age or older were screened using a detailed neuropsychological protocol, and 31 participants, comprising 14 superagers and 17 cognitively average elderly controls, were included for analysis...
March 16, 2023: AJNR. American Journal of Neuroradiology
#23
JOURNAL ARTICLE
Natalia Gomes Gonçalves, Márlon Juliano Romero Aliberti, Laiss Bertola, Thiago Avelino-Silva, Murilo Bacchini Dias, Daniel Apolinario, Geraldo Busatto, Orestes Forlenza, Ricardo Nitrini, Sonia Maria Dozzi Brucki, Andre Russowsky Brunoni, Kallene Summer Moreira Vidal, Wilson Jacob-Filho, Claudia Kimie Suemoto
INTRODUCTION: Cognitive impairment is common after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, associations between post-hospital discharge risk factors and cognitive trajectories have not been explored. METHODS: A total of 1105 adults (mean age ± SD 64.9 ± 9.9 years, 44% women, 63% White) with severe coronavirus disease 2019 (COVID-19) were evaluated for cognitive function 1 year after hospital discharge. Scores from cognitive tests were harmonized, and clusters of cognitive impairment were defined using sequential analysis...
September 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#24
JOURNAL ARTICLE
Viviane A Carvalho de Morais, Ana V de Oliveira-Pinto, Arthur F Mello Neto, Jaqueline S Freitas, Magnólia M da Silva, Claudia Kimie Suemoto, Renata P Leite, Lea T Grinberg, Wilson Jacob-Filho, Carlos Pasqualucci, Ricardo Nitrini, Paulo Caramelli, Roberto Lent
BACKGROUND: Education is believed to contribute positively to brain structure and function, as well as to cognitive reserve. One of the brain regions most impacted by education is the medial temporal lobe (MTL), a region that houses the hippocampus, which has an important role in learning processes and in consolidation of memories, and is also known to undergo neurogenesis in adulthood. We aimed to investigate the influence of education on the absolute cell numbers of the MTL (comprised by the hippocampal formation, amygdala, and parahippocampal gyrus) of men without cognitive impairment...
January 5, 2023: Brain Sciences
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JOURNAL ARTICLE
Eliana C B Toscano, Érica L M Vieira, Lea T Grinberg, Natalia P Rocha, Joseane A S Brant, Regina S Paradela, Alexandre V Giannetti, Claudia K Suemoto, Renata E P Leite, Ricardo Nitrini, Milene A Rachid, Antonio L Teixeira
Temporal lobe epilepsy (TLE) often courses with cognitive deficits, but its underlying neuronal basis remains unclear. Confluent data suggest that epilepsy share pathophysiological mechanisms with neurodegenerative diseases. However, as most studies analyze subjects 60 years old and older, it is challenging to rule out that neurodegenerative changes arise from age-related mechanisms rather than epilepsy in these individuals. To fill this gap, we conducted a neuropathological investigation of the hippocampal formation of 22 adults with mesial TLE and 20 age- and sex-matched controls (both younger than 60 years)...
January 9, 2023: Molecular Neurobiology
#26
JOURNAL ARTICLE
Isabel Junqueira de Almeida, Marcela Lima Silagi, Maria Teresa Carthery-Goulart, Jacy Bezerra Parmera, Mario Amore Cecchini, Artur Martins Coutinho, Sonia Maria Dozzi Brucki, Ricardo Nitrini, Eliane Schochat
The aim of this study was to characterize the oral discourse of CBS patients and to verify whether measures obtained during a semi-spontaneous speech production could differentiate CBS patients from controls. A second goal was to compare the performance of patients with CBS probably due to Alzheimer's disease (CBS-AD) pathology and CBS not related to AD (CBS-non-AD) in the same measures, based on the brain metabolic status (FDG-PET) and in the presence of amyloid deposition (amyloid-PET). Results showed that CBS patients were significantly different from controls in speech rate, lexical level, informativeness, and syntactic complexity...
December 12, 2022: Brain Sciences
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JOURNAL ARTICLE
Jerusa Smid, Adalberto Studart-Neto, Karolina Gouveia César-Freitas, Marcia Cristina Nascimento Dourado, Renata Kochhann, Breno José Alencar Pires Barbosa, Lucas Porcello Schilling, Márcio Luiz Figueiredo Balthazar, Norberto Anízio Ferreira Frota, Leonardo Cruz de Souza, Paulo Caramelli, Paulo Henrique Ferreira Bertolucci, Márcia Lorena Fagundes Chaves, Sonia Maria Dozzi Brucki, Ricardo Nitrini, Elisa de Paula França Resende, Francisco Assis Carvalho Vale
This consensus, performed by the Brazilian Academy of Neurology (BAN) will approach practically how to evaluate patients with cognitive complaints and how to clinically and etiologically diagnose the three clinical syndromes associated with the different stages of cognitive decline: subjective cognitive decline (SCD), mild cognitive impairment (MCI), and dementia. This BAN consensus discusses SCD diagnosis for the first time, updates MCI and dementia diagnoses, recommends the adequate cognitive tests and the relevant etiological work-up and care of patients with cognitive decline at different levels of care within the Brazilian Unified Health System...
September 2022: Dementia & Neuropsychologia
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JOURNAL ARTICLE
Breno José Alencar Pires Barbosa, José Ibiapina Siqueira, Gilberto Sousa Alves, Felipe Kenji Sudo, Claudia Kimie Suemoto, Fernanda Tovar-Moll, Jerusa Smid, Lucas Porcello Schilling, Marcio Luiz Figueredo Balthazar, Norberto Anízio Ferreira Frota, Leonardo Cruz de Souza, Francisco Assis Carvalho Vale, Paulo Caramelli, Paulo Henrique Ferreira Bertolucci, Sonia Maria Dozzi Brucki, Ricardo Nitrini, Eliasz Engelhardt, Márcia Lorena Fagundes Chaves
Since the publication of the latest recommendations for the diagnosis and treatment of Vascular Dementia by the Brazilian Academy of Neurology in 2011, significant advances on the terminology and diagnostic criteria have been made. This manuscript is the result of a consensus among experts appointed by the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology (2020-2022). We aimed to update practical recommendations for the identification, classification, and diagnosis of Vascular Cognitive Impairment (VCI)...
September 2022: Dementia & Neuropsychologia
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JOURNAL ARTICLE
Leonardo Cruz de Souza, Mirna Lie Hosogi, Thais Helena Machado, Maria Teresa Carthery-Goulart, Mônica Sanches Yassuda, Jerusa Smid, Breno José Alencar Pires Barbosa, Lucas Porcello Schilling, Marcio Luiz Figueredo Balthazar, Norberto Anízio Ferreira Frota, Francisco Assis Carvalho Vale, Paulo Caramelli, Paulo Henrique Ferreira Bertolucci, Márcia Lorena Fagundes Chaves, Sonia Maria Dozzi Brucki, Ricardo Nitrini, Valéria Santoro Bahia, Leonel Tadao Takada
"Frontotemporal dementia" (FTD) is a clinical syndrome characterized by the focal involvement of the frontal and/or temporal lobes. FTD has three clinical phenotypes: the behavioral variant and two linguistic subtypes, namely, non-fluent/agrammatic primary progressive aphasia (PPA-NF/A) and semantic PPA (PPA-S). FTD is the second most common cause of dementia in individuals under the age of 65 years. This article presents recommendations for the diagnosis of FTD in the Brazilian scenario, considering the three levels of complexity of the health system: primary health care, secondary and tertiary levels...
September 2022: Dementia & Neuropsychologia
#30
JOURNAL ARTICLE
Lucas Porcello Schilling, Marcio Luiz Figueredo Balthazar, Márcia Radanovic, Orestes Vicente Forlenza, Marcela Lima Silagi, Jerusa Smid, Breno José Alencar Pires Barbosa, Norberto Anízio Ferreira Frota, Leonardo Cruz de Souza, Francisco Assis Carvalho Vale, Paulo Caramelli, Paulo Henrique Ferreira Bertolucci, Márcia Lorena Fagundes Chaves, Sonia Maria Dozzi Brucki, Benito Pereira Damasceno, Ricardo Nitrini
This paper presents the consensus of the Scientific Department of Cognitive Neurology and Aging from the Brazilian Academy of Neurology on the diagnostic criteria for Alzheimer's disease (AD) in Brazil. The authors conducted a literature review regarding clinical and research criteria for AD diagnosis and proposed protocols for use at primary, secondary, and tertiary care levels. Within this clinical scenario, the diagnostic criteria for typical and atypical AD are presented as well as clinical, cognitive, and functional assessment tools and complementary propaedeutics with laboratory and neuroimaging tests...
September 2022: Dementia & Neuropsychologia
#31
JOURNAL ARTICLE
Jacy Bezerra Parmera, Vitor Tumas, Henrique Ballalai Ferraz, Mariana Spitz, Maira Tonidandel Barbosa, Jerusa Smid, Breno José Alencar Pires Barbosa, Lucas Porcello Schilling, Márcio Luiz Figueiredo Balthazar, Leonardo Cruz de Souza, Francisco Assis Carvalho Vale, Paulo Caramelli, Paulo Henrique Ferreira Bertolucci, Márcia Lorena Fagundes Chaves, Sonia Maria Dozzi Brucki, Ricardo Nitrini, Raphael Machado Castilhos, Norberto Anízio Ferreira Frota
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) represent the second most common type of degenerative dementia in patients aged 65 years and older, leading to progressive cognitive dysfunction and impaired quality of life. This study aims to provide a consensus based on a systematic Brazilian literature review and a comprehensive international review concerning PDD and DLB. Moreover, we sought to report on and give recommendations about the best diagnostic approaches focusing on primary and secondary care...
September 2022: Dementia & Neuropsychologia
#32
JOURNAL ARTICLE
Sonia Maria Dozzi Brucki, Ivan Aprahamian, Wyllians Vendramini Borelli, Victor Calil da Silveira, Ceres Eloah de Lucena Ferretti, Jerusa Smid, Breno José Alencar Pires Barbosa, Lucas Porcello Schilling, Márcio Luiz Figueiredo Balthazar, Norberto Anízio Ferreira Frota, Leonardo Cruz de Souza, Francisco Assis Carvalho Vale, Paulo Caramelli, Paulo Henrique Ferreira Bertolucci, Márcia Lorena Fagundes Chaves, Ricardo Nitrini, Rodrigo Rizek Schultz, Lilian Schafirovits Morillo
Alzheimer's disease (AD) and other neurodegenerative dementias have a progressive course, impairing cognition, functional capacity, and behavior. Most studies have focused on AD. Severe dementia is associated with increased age, higher morbidity-mortality, and rising costs of care. It is fundamental to recognize that severe dementia is the longest period of progression, with patients living for many years in this stage. It is the most heterogeneous phase in the process, with different abilities and life expectancies...
September 2022: Dementia & Neuropsychologia
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JOURNAL ARTICLE
Paulo Caramelli, Valeska Marinho, Jerson Laks, Marcus Vinicius Della Coletta, Florindo Stella, Einstein Francisco Camargos, Jerusa Smid, Breno José Alencar Pires Barbosa, Lucas Porcello Schilling, Marcio Luiz Figueredo Balthazar, Norberto Anízio Ferreira Frota, Leonardo Cruz de Souza, Francisco Assis Carvalho Vale, Márcia Lorena Fagundes Chaves, Sonia Maria Dozzi Brucki, Ricardo Nitrini, Helen Bedinoto Durgante, Paulo Henrique Ferreira Bertolucci
There is currently no cure for neurodegenerative or vascular dementias, but some pharmacological and non-pharmacological interventions may contribute to alleviate symptoms, slow disease progression and improve quality of life. Current treatment approaches are based on etiology, symptom profile and stage of dementia. This manuscript presents recommendations on pharmacological and non-pharmacological treatments of dementia due to Alzheimer's disease, vascular cognitive impairment, frontotemporal dementia, Parkinson's disease dementia, and dementia with Lewy bodies...
September 2022: Dementia & Neuropsychologia
#34
JOURNAL ARTICLE
Camila de Godoi Carneiro, Daniele de Paula Faria, Artur Martins Coutinho, Carla Rachel Ono, Fábio Luis de Souza Duran, Naomi Antunes da Costa, Alexandre Teles Garcez, Paula Squarzoni da Silveira, Orestes Vicente Forlenza, Sonia Maria Dozzi Brucki, Ricardo Nitrini, Geraldo Busatto, Carlos Alberto Buchpiguel
OBJECTIVE: Positron emission tomography (PET) allows in vivo evaluation of molecular targets in neurodegenerative diseases, such as Alzheimer's disease. Mild cognitive impairment is an intermediate stage between normal cognition and Alzheimer-type dementia. In vivo fibrillar amyloid-beta can be detected in PET using [11C]-labeled Pittsburgh compound B (11C-PiB). In contrast, [18F]fluoro-2-deoxy-d-glucose (18F-FDG) is a neurodegeneration biomarker used to evaluate cerebral glucose metabolism, indicating neuronal injury and synaptic dysfunction...
August 15, 2022: Revista Brasileira de Psiquiatria
#35
JOURNAL ARTICLE
Claudia K Suemoto, Naaheed Mukadam, Sonia M D Brucki, Paulo Caramelli, Ricardo Nitrini, Jerson Laks, Gill Livingston, Cleusa P Ferri
INTRODUCTION: Twelve risk factors (RFs) account for 40% of dementia cases worldwide. However, most data for population attributable fractions (PAFs) are from high-income countries (HIC). We estimated how much these RFs account for dementia cases in Brazil, stratifying estimates by race and socioeconomic level. METHODS: We calculated the prevalence and communalities of 12 RFs using 9412 Brazilian Longitudinal Study of Aging participants, then stratified according to self-reported race and country macro-regions...
November 3, 2022: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#36
RANDOMIZED CONTROLLED TRIAL
Bruno Caramelli, Pai Ching Yu, Francisco A M Cardozo, Iuri R Magalhães, Raphael R Spera, Daniel K Amado, Maria C Escalante-Rojas, Danielle M Gualandro, Daniela Calderaro, Caio A M Tavares, Flavio A Borges-Junior, Adriana F Pastana, Mariana G Matheus, Sonia M D Brucki, Ana Carolina O Rodrigues, Ricardo Nitrini, Paulo Caramelli
BACKGROUND: Observational studies support a role for oral anticoagulation to reduce the risk of dementia in atrial fibrillation patients, but conclusive data are lacking. Since dabigatran offers a more stable anticoagulation, we hypothesized it would reduce cognitive decline when compared to warfarin in old patients with atrial fibrillation. METHODS: The GIRAF trial was a 24-month, randomized, parallel-group, controlled, open-label, hypothesis generating trial. The trial was done in six centers including a geriatric care unit, secondary and tertiary care cardiology hospitals in São Paulo, Brazil...
October 26, 2022: BMC Medicine
#37
JOURNAL ARTICLE
Regina Silva Paradela, Daniela Souza Farias-Itao, Renata E P Leite, Carlos A Pasqualucci, Lea T Grinberg, Michel Satya Naslavsky, Mayana Zatz, Ricardo Nitrini, Wilson Jacob-Filho, Claudia Kimie Suemoto
BACKGROUND: Apolipoprotein E gene (APOE) ε4 allele is associated with a higher risk of carotid atherosclerosis, but less is known about the association of APOE with intracranial atherosclerotic disease (IAD). We aimed to investigate the association of APOE alleles with IAD in a cross-sectional autopsy study. METHODS: We measured the stenosis in the 12 arteries of the Circle of Willis using postmortem morphometric measurements. The APOE polymorphism was determined by real-time polymerase chain reaction...
September 22, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
#38
JOURNAL ARTICLE
Lucy L Gibson, Lea T Grinberg, Dominic Ffytche, Renata E P Leite, Roberta D Rodriguez, Renata E L Ferretti-Rebustini, Carlos A Pasqualucci, Ricardo Nitrini, Wilson Jacob-Filho, Dag Aarsland, Claudia K Suemoto
INTRODUCTION: Neuropsychiatric symptoms (NPS) are common in Lewy body disease (LBD), but their etiology is poorly understood. METHODS: In a population-based post mortem study neuropathological data was collected for Lewy body (LB) neuropathology, neurofibrillary tangles (NFT), amyloid beta burden, TDP-43, lacunar infarcts, cerebral amyloid angiopathy (CAA), and hyaline atherosclerosis. Post mortem interviews collected systematic information regarding NPS and cognitive status...
September 23, 2022: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#39
JOURNAL ARTICLE
Mario A Parra, Paulina Orellana, Tomas Leon, Cabello G Victoria, Fernando Henriquez, Rodrigo Gomez, Constanza Avalos, Andres Damian, Andrea Slachevsky, Agustin Ibañez, Henrik Zetterberg, Betty M Tijms, Jennifer S Yokoyama, Stefanie D Piña-Escudero, J Nicholas Cochran, Diana L Matallana, Daisy Acosta, Ricardo Allegri, Bianca P Arias-Suárez, Bernardo Barra, Maria Isabel Behrens, Sonia M D Brucki, Geraldo Busatto, Paulo Caramelli, Sheila Castro-Suarez, Valeria Contreras, Nilton Custodio, Sergio Dansilio, Myriam De la Cruz-Puebla, Leonardo Cruz de Souza, Monica M Diaz, Lissette Duque, Gonzalo A Farías, Sergio T Ferreira, Nahuel Magrath Guimet, Ana Kmaid, David Lira, Francisco Lopera, Beatriz Mar Meza, Eliane C Miotto, Ricardo Nitrini, Alberto Nuñez, Santiago O'Neill, John Ochoa, Maritza Pintado-Caipa, Elisa de Paula França Resende, Shannon Risacher, Luz Angela Rojas, Valentina Sabaj, Lucas Schilling, Allis F Sellek, Ana Sosa, Leonel T Takada, Antonio L Teixeira, Martha Unaucho-Pilalumbo, Claudia Duran-Aniotz
Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training...
September 13, 2022: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#40
JOURNAL ARTICLE
Michel Satya Naslavsky, Claudia K Suemoto, Luciano Abreu Brito, Marília Oliveira Scliar, Renata Eloah Ferretti-Rebustini, Roberta Diehl Rodriguez, Renata E P Leite, Nathalia Matta Araujo, Victor Borda, Eduardo Tarazona-Santos, Wilson Jacob-Filho, Carlos Pasqualucci, Ricardo Nitrini, Kristine Yaffe, Mayana Zatz, Lea T Grinberg
Dementia is more prevalent in Blacks than in Whites, likely due to a combination of environmental and biological factors. Paradoxically, clinical studies suggest an attenuation of APOE ε4 risk of dementia in African ancestry (AFR), but a dearth of neuropathological data preclude the interpretation of the biological factors underlying these findings, including the association between APOE ε4 risk and Alzheimer's disease (AD) pathology, the most frequent cause of dementia. We investigated the interaction between African ancestry, AD-related neuropathology, APOE genotype, and functional cognition in a postmortem sample of 400 individuals with a range of AD pathology severity and lack of comorbid neuropathology from a cohort of community-dwelling, admixed Brazilians...
September 7, 2022: Molecular Psychiatry
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