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Karolina G César, Mônica S Yassuda, Fabio H G Porto, Sonia M D Brucki, Ricardo Nitrini
BACKGROUND: Several cognitive tools have been developed aiming to diagnose dementia. The cognitive battery Addenbrooke's Cognitive Examination - Revised (ACE-R) has been used to detect cognitive impairment; however, there are few studies including samples with low education. The aim of the study was to provide ACE-R norms for seniors within a lower education, including illiterates. An additional aim was to examine the accuracy of the ACE-R to detect dementia and cognitive impairment no dementia (CIND)...
May 17, 2017: International Psychogeriatrics
Claudia K Suemoto, Renata E L Ferretti-Rebustini, Roberta D Rodriguez, Renata E P Leite, Luciana Soterio, Sonia M D Brucki, Raphael R Spera, Tarcila M Cippiciani, Jose M Farfel, Alexandre Chiavegatto Filho, Michel Satya Naslavsky, Mayana Zatz, Carlos A Pasqualucci, Wilson Jacob-Filho, Ricardo Nitrini, Lea T Grinberg
BACKGROUND: Clinicopathological studies are important in determining the brain lesions underlying dementia. Although almost 60% of individuals with dementia live in developing countries, few clinicopathological studies focus on these individuals. We investigated the frequency of neurodegenerative and vascular-related neuropathological lesions in 1,092 Brazilian admixed older adults, their correlation with cognitive and neuropsychiatric symptoms, and the accuracy of dementia subtype diagnosis...
March 2017: PLoS Medicine
A J Ehrenberg, A K Nguy, P Theofilas, S Dunlop, C K Suemoto, A T Di Lorenzo Alho, R P Leite, R Diehl Rodriguez, M B Mejia, U Rüb, J M Farfel, R E de Lucena Ferretti-Rebustini, C F Nascimento, R Nitrini, C A Pasquallucci, W Jacob-Filho, B Miller, W W Seeley, H Heinsen, L T Grinberg
AIMS: Hyperphosphorylated tau neuronal cytoplasmic inclusions (ht-NCI) are the best protein correlate of clinical decline in Alzheimer's disease (AD). Qualitative evidence identifies ht-NCI accumulating in the isodendritic core before the entorhinal cortex. Here, we used unbiased stereology to quantify ht-NCI burden in the locus coeruleus (LC) and dorsal raphe nucleus (DRN), aiming to characterize the impact of AD pathology in these nuclei with a focus on early stages. METHODS: We utilized unbiased stereology in a sample of 48 well-characterized subjects enriched for controls and early AD stages...
January 24, 2017: Neuropathology and Applied Neurobiology
Henrique C S Muela, Valeria A Costa-Hong, Mônica S Yassuda, Natália C Moraes, Claudia M Memória, Michel F Machado, Thiago A Macedo, Edson B S Shu, Ayrton R Massaro, Ricardo Nitrini, Alfredo J Mansur, Luiz A Bortolotto
BACKGROUND: Most evidence of target-organ damage in hypertension (HTN) is related to the kidneys and heart. Cerebrovascular and cognitive impairment are less well studied. Therefore, this study analyzed changes in cognitive function in patients with different stages of hypertension compared to nonhypertensive controls. METHODS AND RESULTS: In a cross-sectional study, 221 (71 normotensive and 150 hypertensive) patients were compared. Patients with hypertension were divided into 2 stages according to blood pressure (BP) levels or medication use (HTN-1: BP, 140-159/90-99 or use of 1 or 2 antihypertensive drugs; HTN-2: BP, ≥160/100 or use of ≥3 drugs)...
January 11, 2017: Journal of the American Heart Association
Paula Villela Nunes, Claudia Kimie Suemoto, Renata Elaine Paraizo Leite, Renata Eloah de Lucena Ferretti-Rebustini, Carlos Augusto Pasqualucci, Ricardo Nitrini, Jose Marcelo Farfel, Katia Cristina de Oliveira, Lea Tenenholz Grinberg, Nicole Rezende da Costa, Camila Fernandes Nascimento, Faraz Salmasi, Helena Kyunghee Kim, Lionel Trevor Young, Wilson Jacob-Filho, Beny Lafer
OBJECTIVE: We examined brain volume and atrophy in individuals with major depressive disorder (MDD) without dementia that were referred to a large autopsy service. We also examined potential risk factors for brain atrophy, including demographics and clinical variables. METHODS: In this study, 1373 participants (787 male) aged 50 years or older who died from natural causes were included. Participants with no reliable informant, with cognitive impairment or dementia, with a medical history of severe chronic disease, or with prolonged agonal state were excluded...
January 5, 2017: International Journal of Geriatric Psychiatry
Ronnyson Susano Grativvol, Mateus Mistieri Simabukuro, Raphael Ribeiro Spera, Wagner Cid Palmeira Cavalcante, Hugo Henrique Soares Araújo, Daniel Sakuno, Leandro Tavares Lucato, Lécio Figueira Pinto, Luiz Henrique Martins Castro, Ricardo Nitrini
No abstract text is available yet for this article.
November 2016: Arquivos de Neuro-psiquiatria
Karla Shimura Barea Leite, Eliane Correa Miotto, Ricardo Nitrini, Mônica Sanches Yassuda
BACKGROUND: The aims of this study were (1) to describe and compare the performance of illiterate and low-educated older adults, without evidence of cognitive impairment, on different versions of the Boston Naming Test (BNT) original, Brazilian adapted, abbreviated 30-item (even and odd) and 15-item from the CERAD (Consortium to Establish a Registry for Alzheimer's Disease) battery; (2) to compare performance on the original versus adapted versions of the BNT. METHODS: A total of 180 healthy older adults (60 years or older) were stratified according to educational level (0, 1-2, and 3-4 years), and age (60-69, 70-79, and ≥ 80 years)...
November 23, 2016: International Psychogeriatrics
Adalberto Studart Neto, Herval R Soares Neto, Mateus M Simabukuro, Davi J F Solla, Márcia R R Gonçalves, Ida Fortini, Luiz H M Castro, Ricardo Nitrini
BACKGROUND: Rapidly progressive dementia (RPD) is usually associated with Creutzfeldt-Jakob disease, a fatal condition. Current advances in the understanding of immune-mediated diseases allow the diagnosis of previously unrecognized treatable RPDs. OBJECTIVE OF THE STUDY: The objective of the study was to describe the prevalence and causes of RPD in a neurology service, identifying potentially reversible causes. METHODS: We carried out a cross-sectional evaluation of all patients admitted to the neurology unit of a tertiary hospital in Brazil between March 2012 and February 2015...
November 15, 2016: Alzheimer Disease and Associated Disorders
Luciana Cassimiro, Daniel Fuentes, Ricardo Nitrini, Mônica Sanches Yassuda
OBJECTIVE: This study investigated the pattern of decision-making (DM) on the Iowa Gambling Task (IGT) in a sample of Portuguese speaking healthy older women in Brazil with limited education: illiterate, 1-2 years, and 3-4 years of schooling. METHODS: Around 164 non-demented community-dwelling women participated in the study. Among them 60 were illiterate, 52 had 1-2 years of schooling and 52 had 3-4 years of schooling. Participants completed the instruments: Brief Cognitive Screening Battery (BCSB), Mini-Mental State Examination, Verbal Fluency Test (animal category), Clock Drawing Test, Geriatric Depression Scale, Geriatric Anxiety Inventory, Digit Span Forward and Backward, Raven's Coloured Progressive Matrices, Wisconsin Card Sorting Test, and IGT...
February 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
José Augusto Ferrari Cestari, Gisele Maria Campos Fabri, Jorge Kalil, Ricardo Nitrini, Wilson Jacob-Filho, José Tadeu Tesseroli de Siqueira, Silvia Regina D T Siqueira
No abstract text is available yet for this article.
September 6, 2016: Journal of Alzheimer's Disease: JAD
Panos Theofilas, Alexander J Ehrenberg, Sara Dunlop, Ana T Di Lorenzo Alho, Austin Nguy, Renata Elaine Paraizo Leite, Roberta Diehl Rodriguez, Maria B Mejia, Claudia K Suemoto, Renata Eloah De Lucena Ferretti-Rebustini, Livia Polichiso, Camila F Nascimento, William W Seeley, Ricardo Nitrini, Carlos Augusto Pasqualucci, Wilson Jacob Filho, Udo Rueb, John Neuhaus, Helmut Heinsen, Lea T Grinberg
INTRODUCTION: Alzheimer's disease (AD) progression follows a specific spreading pattern, emphasizing the need to characterize those brain areas that degenerate first. The brainstem's locus coeruleus (LC) is the first area to develop neurofibrillary changes (neurofibrillary tangles [NFTs]). METHODS: The methods include unbiased stereological analyses in human brainstems to estimate LC volume and neuronal population in controls and individuals across all AD stages...
March 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
H C S Muela, V Costa-Hong, M F Machado, M S Yassuda, E B S Shu, A R Massaro, R Nitrini, L Bortolotto
OBJECTIVE: To study the cognitive function at different domains and arterial properties in patients with AH stage 1 to 3 compared to normotensives and to evaluate the correlations between these variables. DESIGN AND METHOD: We evaluated 162 subjects, 42 normotensives (44.7 ± 11 yrs, 69% male, 88% white) and 120 patients with stage 1-3 AH (51 ± 11 yrs, 46% male, 69% white) under treatment. The global cognitive function was assessed by Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA)...
September 2016: Journal of Hypertension
Fábio H G Porto, Artur M Coutinho, Leandro T Lucato, Carlos Alberto Buchpiguel, Ricardo Nitrini
No abstract text is available yet for this article.
August 2, 2016: Neurology
Lea T Grinberg, Renato Anghinah, Camila Fernandes Nascimento, Edson Amaro, Renata P Leite, Maria da Graça M Martin, Michel S Naslavsky, Leonel T Takada, Wilson Jacob Filho, Carlos A Pasqualucci, Ricardo Nitrini
The relationship between soccer and chronic traumatic encephalopathy (CTE) is not well established. We report clinicopathological correlations in an 83-year-old retired center-back soccer player, with no history of concussion, manifesting typical Alzheimer-type dementia. Examination revealed mixed pathology including widespread CTE, moderate Alzheimer's disease, hippocampal sclerosis, and TDP-43 proteinopathy. This case adds to a few CTE cases described in soccer players. Furthermore, it corroborates that CTE may present clinically as typical Alzheimer-type dementia...
July 29, 2016: Journal of Alzheimer's Disease: JAD
Renata Eloah de Lucena Ferretti-Rebustini, Marcos Alencar Abaide Balbinotti, Wilson Jacob-Filho, Flávio Rebustini, Claudia Kimie Suemoto, Carlos Augusto Gonçalves Pasqualucci, José Marcelo Farfel, Renata Elaine Paraizo Leite, Lea Tenenholz Grinberg, Ricardo Nitrini
OBJECTIVE: To analyze the evidences of construct validity of the Katz Index for the retrospective assessment of activities of daily living (ADL) by informants, to assist neuropathological studies in the elderly. METHOD: A cross-sectional study analyzed the functional ability of ADL measure by the Katz Index, of 650 cases randomly selected from the Brazilian Brain Bank of the Ageing Brain Study Group (BBBABSG) database. Sample was divided in two subsamples for the analysis (N=325, each) and then stratified according to cognitive decline assessed by the Clinical Dementia Rating Scale (CDR)...
December 2015: Revista da Escola de Enfermagem da U S P
Roberta Diehl Rodriguez, Claudia Kimie Suemoto, Mariana Molina, Camila Fernandes Nascimento, Renata Elaine Paraizo Leite, Renata Eloah de Lucena Ferretti-Rebustini, José Marcelo Farfel, Helmut Heinsen, Ricardo Nitrini, Kenji Ueda, Carlos Augusto Pasqualucci, Wilson Jacob-Filho, Kristine Yaffe, Lea Tenenholz Grinberg
Argyrophilic grain disease (AGD) is a frequent late-onset, 4-repeat tauopathy reported in Caucasians with high educational attainment. Little is known about AGD in non-Caucasians or in those with low educational attainment. We describe AGD demographics, clinical, and neuropathological features in a multiethnic cohort of 983 subjects ≥50 years of age from São Paulo, Brazil. Clinical data were collected through semistructured interviews with an informant and included in the Informant Questionnaire on Cognitive Decline in the Elderly, the Clinical Dementia Rating, and the Neuropsychiatric Inventory...
July 2016: Journal of Neuropathology and Experimental Neurology
José Augusto Ferrari Cestari, Gisele Maria Campos Fabri, Jorge Kalil, Ricardo Nitrini, Wilson Jacob-Filho, José Tadeu Tesseroli de Siqueira, Silvia Regina D T Siqueira
BACKGROUND: Oral infections are prevalent in the adult population. Their impact includes the implication as a risk factor for Alzheimer's disease (AD), altering its progression. One of the potential mechanisms involves immune mediators such as circulating cytokines. OBJECTIVE: The goal of the present study was to investigate the prevalence of oral infections and blood levels of IL-1β, TNF-α, and IL-6 in patients with AD, mild cognitive impairment (MCI), and controls...
April 19, 2016: Journal of Alzheimer's Disease: JAD
Leonel T Takada, Valeria S Bahia, Henrique C Guimarães, Thais V M M Costa, Thiago C Vale, Roberta D Rodriguez, Fabio H G Porto, João C B Machado, Rogério G Beato, Karolina G Cesar, Jerusa Smid, Camila F Nascimento, Lea T Grinberg, Sonia M D Brucki, Jessica R Maximino, Sarah T Camargos, Gerson Chadi, Paulo Caramelli, Ricardo Nitrini
BACKGROUND: Mutations in GRN (progranulin) and MAPT (microtubule-associated protein tau) are among the most frequent causes of monogenic frontotemporal dementia (FTD), but data on the frequency of these mutations in regions such as Latin America are still lacking. OBJECTIVE: We aimed to investigate the frequencies of GRN and MAPT mutations in FTD cohorts from 2 Brazilian dementia research centers, the University of Sao Paulo and the Federal University of Minas Gerais medical schools...
October 2016: Alzheimer Disease and Associated Disorders
Tânia M da Silva Novaretti, Maria I D'Ávila Freitas, Letícia L Mansur, Ricardo Nitrini, Marcia Radanovic
OBJECTIVES: Depression and dementia are highly prevalent in the elderly. Language impairment is an inherent component of Alzheimer's disease (AD), which can also be encountered in depressed patients. The aim of this study wasto compare the profiles of language abilities in late-onset depression and mild AD groups. METHODS: We studied 25 patients with late-onset depression (mean age 73.6 ± 6.6 years; schooling 9.1 ± 5.7 years) and 30 patients with mild AD (77.6 ± 5...
April 2011: Acta Neuropsychiatrica
Juliana N de Souza-Talarico, Anna P de Carvalho, Sonia M D Brucki, Ricardo Nitrini, Renata E de L Ferretti-Rebustini
Population aging has been accompanied by worldwide growth in dementia. However, little is known about the prevalence of dementia and cognitive impairment not dementia in ethnically diverse populations, such as indigenous populations conceptualized as groups of persons who self-identify as indigenous and who are recognized as distinctive communities reproducing ancestral, historical, and territorial culture. This is particularly relevant in view of increasing life expectancy in indigenous populations and, consequently, in the number of elderly people, as well as the changes in their multimorbidity profile...
July 2016: Alzheimer Disease and Associated Disorders
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