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https://www.readbyqxmd.com/read/29234599/selecting-the-most-relevant-brain-regions-to-discriminate-alzheimer-s-disease-patients-from-healthy-controls-using-multiple-kernel-learning-a-comparison-across-functional-and-structural-imaging-modalities-and-atlases
#1
Jane Maryam Rondina, Luiz Kobuti Ferreira, Fabio Luis de Souza Duran, Rodrigo Kubo, Carla Rachel Ono, Claudia Costa Leite, Jerusa Smid, Ricardo Nitrini, Carlos Alberto Buchpiguel, Geraldo F Busatto
Background: Machine learning techniques such as support vector machine (SVM) have been applied recently in order to accurately classify individuals with neuropsychiatric disorders such as Alzheimer's disease (AD) based on neuroimaging data. However, the multivariate nature of the SVM approach often precludes the identification of the brain regions that contribute most to classification accuracy. Multiple kernel learning (MKL) is a sparse machine learning method that allows the identification of the most relevant sources for the classification...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29213517/soccer-football-association-and-chronic-traumatic-encephalopathy-a-short-review-and-recommendation
#2
REVIEW
Ricardo Nitrini
Chronic traumatic encephalopathy (CTE) was initially described in boxers, but in recent years it has been reported in other settings, particularly in contact sports and military personnel. Soccer (football association) had previously been (and still is) considered relatively safe when compared to other sports, such as American football. However, a few cases of professional soccer players with CTE have been reported in the last few years. It is still unknown how frequent this condition is in soccer players, and the role played by heading the ball remains elusive...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213516/in-the-september-2017-issue
#3
EDITORIAL
Ricardo Nitrini
No abstract text is available yet for this article.
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213509/comparative-analysis-of-the-electroencephalogram-in-patients-with-alzheimer-s-disease-diffuse-axonal-injury-patients-and-healthy-controls-using-loreta-analysis
#4
Jéssica Natuline Ianof, Francisco José Fraga, Leonardo Alves Ferreira, Renato Teodoro Ramos, José Luiz Carlos Demario, Regina Baratho, Luís Fernando Hindi Basile, Ricardo Nitrini, Renato Anghinah
Alzheimer's disease (AD) is a dementia that affects a large contingent of the elderly population characterized by the presence of neurofibrillary tangles and senile plaques. Traumatic brain injury (TBI) is a non-degenerative injury caused by an external mechanical force. One of the main causes of TBI is diffuse axonal injury (DAI), promoted by acceleration-deceleration mechanisms. Objective: To understand the electroencephalographic differences in functional mechanisms between AD and DAI groups...
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213500/editorial-in-the-june-2017-issue
#5
EDITORIAL
Ricardo Nitrini
No abstract text is available yet for this article.
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213486/editorial-in-the-march-2017-issue
#6
EDITORIAL
Ricardo Nitrini
No abstract text is available yet for this article.
January 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29106057/higher-arterial-stiffness-is-associated-with-lower-cognitive-performance-in-patients-with-hypertension
#7
Henrique C S Muela, Valeria A Costa-Hong, Mônica S Yassuda, Natália C Moraes, Claudia M Memória, Michel F Machado, Edson Bor-Seng-Shu, Ricardo C Nogueira, Alfredo J Mansur, Ayrton R Massaro, Ricardo Nitrini, Thiago A Macedo, Luiz A Bortolotto
Cognitive impairment and elevated arterial stiffness have been described in patients with arterial hypertension, but their association has not been well studied. We evaluated the correlation of arterial stiffness and different cognitive domains in patients with hypertension compared with those with normotension. We evaluated 211 patients (69 with normotension and 142 with hypertension). Patients were age matched and distributed according to their blood pressure: normotension, hypertension stage 1, and hypertension stage 2...
November 5, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29031088/probing-the-correlation-of-neuronal-loss-neurofibrillary-tangles-and-cell-death-markers-across-the-alzheimer-s-disease-braak-stages-a-quantitative-study-in-humans
#8
Panos Theofilas, Alexander J Ehrenberg, Austin Nguy, Julia M Thackrey, Sara Dunlop, Maria B Mejia, Ana T Alho, Renata Elaine Paraizo Leite, Roberta Diehl Rodriguez, Claudia K Suemoto, Camila F Nascimento, Marcus Chin, Daniel Medina-Cleghorn, Ana Maria Cuervo, Michelle Arkin, William W Seeley, Bruce L Miller, Ricardo Nitrini, Carlos Augusto Pasqualucci, Wilson Jacob Filho, Udo Rueb, John Neuhaus, Helmut Heinsen, Lea T Grinberg
Clarifying the mechanisms connecting neurofibrillary tangle (NFT) neurotoxicity to neuronal dysfunction in humans is likely to be pivotal for developing effective treatments for Alzheimer's disease (AD). To model the temporal progression of AD in humans, we used a collection of brains with controls and individuals from each Braak stage to quantitatively investigate the correlation between intraneuronal caspase activation or macroautophagy markers, NFT burden, and neuronal loss, in the dorsal raphe nucleus and locus coeruleus, the earliest vulnerable areas to NFT accumulation...
September 20, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28984587/diabetes-is-not-associated-with-alzheimer-s-disease-neuropathology
#9
Maria Niures Pimentel Dos Santos Matioli, Claudia Kimie Suemoto, Roberta Diehl Rodriguez, Daniela Souza Farias, Magnólia Moreira da Silva, Renata Elaine Paraizo Leite, Renata Eloah Lucena Ferretti-Rebustini, José Marcelo Farfel, Carlos Augusto Pasqualucci, Wilson Jacob Filho, Zoe Arvanitakis, Michel Satya Naslavsky, Mayana Zatz, Lea Tenenholz Grinberg, Ricardo Nitrini
BACKGROUND: Previous evidence linking diabetes to Alzheimer's disease (AD) neuropathology is mixed and scant data are available from low- and middle-income countries. OBJECTIVE: To investigate the association between diabetes and AD neuropathology in a large autopsy study of older Brazilian adults. METHODS: In this cross-sectional study, diabetes was defined by diagnosis during life or use of antidiabetic medication. A standardized neuropathological examination was performed using immunohistochemistry...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28977066/support-vector-machine-based-classification-of-neuroimages-in-alzheimer-s-disease-direct-comparison-of-fdg-pet-rcbf-spect-and-mri-data-acquired-from-the-same-individuals
#10
Luiz K Ferreira, Jane M Rondina, Rodrigo Kubo, Carla R Ono, Claudia C Leite, Jerusa Smid, Cassio Bottino, Ricardo Nitrini, Geraldo F Busatto, Fabio L Duran, Carlos A Buchpiguel
OBJECTIVE: To conduct the first support vector machine (SVM)-based study comparing the diagnostic accuracy of T1-weighted magnetic resonance imaging (T1-MRI), F-fluorodeoxyglucose-positron emission tomography (FDG-PET) and regional cerebral blood flow single-photon emission computed tomography (rCBF-SPECT) in Alzheimer's disease (AD). METHOD: Brain T1-MRI, FDG-PET and rCBF-SPECT scans were acquired from a sample of mild AD patients (n=20) and healthy elderly controls (n=18)...
October 2, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28894929/recalling-feature-bindings-differentiates-alzheimer-s-disease-from-frontotemporal-dementia
#11
Mario Amore Cecchini, Mônica Sanches Yassuda, Valéria Santoro Bahia, Leonardo Cruz de Souza, Henrique Cerqueira Guimarães, Paulo Caramelli, Maria Teresa Carthery-Goulart, Flávia Patrocínio, Maria Paula Foss, Vitor Tumas, Thaís Bento Lima-Silva, Sônia Maria Dozzi Brucki, Ricardo Nitrini, Sergio Della Sala, Mario A Parra
It has been challenging to identify clinical cognitive markers that can differentiate patients with Alzheimer's disease (AD) from those with behavioral variant frontotemporal dementia (bvFTD). The short-term memory binding (STMB) test assesses the ability to integrate colors and shapes into unified representations and to hold them temporarily during online performance. The objective of this study is to investigate whether free recall deficits during short-term memory binding (STMB) test can differentiate patients with AD from those with bvFTD and controls...
October 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28793370/prevalence-of-tdp-43-proteinopathy-in-cognitively-normal-older-adults-systematic-review-and-meta-analysis
#12
Camila Nascimento, Ana Tereza Di Lorenzo Alho, Caroline Bazan Conceição Amaral, Renata Elane Paraizo Leite, Ricardo Nitrini, Wilson Jacob-Filho, Carlos Augusto Pasqualucci, Suvi Rosa Kastehelmi Hokkanen, Sally Hunter, Hannah Keage, Gabor G Kovacs, Lea Tenenholz Grinberg, Claudia Kimie Suemoto
OBJECTIVE: To perform a systematic review and meta-analysis on the prevalence of TDP-43 proteinopathy in cognitively normal older adults. METHODS: We systematically reviewed and performed a meta-analysis on the prevalence of TDP-43 proteinopathy in older adults with normal cognition, evaluated by the Mini-Mental State Examination or the Clinical Dementia Rating. We estimated the overall prevalence of TDP-43 using random-effect models, and stratified by age, sex, sample size, study quality, antibody used to assess TDP-43 aggregates, analyzed brain regions, Braak stage, CERAD score, hippocampal sclerosis, and geographic location...
August 9, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28760923/teaching-neuroimages-bilateral-intracerebral-hemorrhage-in-expanded-dengue-syndrome
#13
Wagner Cid Palmeira Cavalcante, Herval Ribeiro Soares Neto, Ronnyson Susano Grativvol, Raphael Ribeiro Spera, Fernando Pereira Frassetto, Leandro Tavares Lucato, Ricardo Nitrini
No abstract text is available yet for this article.
August 1, 2017: Neurology
https://www.readbyqxmd.com/read/28658400/high-phenotypic-variability-in-gerstmann-str%C3%A3-ussler-scheinker-disease
#14
Jerusa Smid, Adalberto Studart, Michele Christine Landemberger, Cleiton Fagundes Machado, Paulo Ribeiro Nóbrega, Nathalie Henriques Silva Canedo, Rodrigo Rizek Schultz, Michel Satya Naslavsky, Sérgio Rosemberg, Fernando Kok, Leila Chimelli, Vilma Regina Martins, Ricardo Nitrini
Gerstmann-Sträussler-Scheinker is a genetic prion disease and the most common mutation is p.Pro102Leu. We report clinical, molecular and neuropathological data of seven individuals, belonging to two unrelated Brazilian kindreds, carrying the p.Pro102Leu. Marked differences among patients were observed regarding age at onset, disease duration and clinical presentation. In the first kindred, two patients had rapidly progressive dementia and three exhibited predominantly ataxic phenotypes with variable ages of onset and disease duration...
June 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28511735/addenbrooke-s-cognitive-examination-revised-normative-and-accuracy-data-for-seniors-with-heterogeneous-educational-level-in-brazil
#15
Karolina G César, Mônica S Yassuda, Fabio H G Porto, Sonia M D Brucki, Ricardo Nitrini
BACKGROUND: Several cognitive tools have been developed aiming to diagnose dementia. The cognitive battery Addenbrooke's Cognitive Examination - Revised (ACE-R) has been used to detect cognitive impairment; however, there are few studies including samples with low education. The aim of the study was to provide ACE-R norms for seniors within a lower education, including illiterates. An additional aim was to examine the accuracy of the ACE-R to detect dementia and cognitive impairment no dementia (CIND)...
May 17, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28350821/neuropathological-diagnoses-and-clinical-correlates-in-older-adults-in-brazil-a-cross-sectional-study
#16
Claudia K Suemoto, Renata E L Ferretti-Rebustini, Roberta D Rodriguez, Renata E P Leite, Luciana Soterio, Sonia M D Brucki, Raphael R Spera, Tarcila M Cippiciani, Jose M Farfel, Alexandre Chiavegatto Filho, Michel Satya Naslavsky, Mayana Zatz, Carlos A Pasqualucci, Wilson Jacob-Filho, Ricardo Nitrini, Lea T Grinberg
BACKGROUND: Clinicopathological studies are important in determining the brain lesions underlying dementia. Although almost 60% of individuals with dementia live in developing countries, few clinicopathological studies focus on these individuals. We investigated the frequency of neurodegenerative and vascular-related neuropathological lesions in 1,092 Brazilian admixed older adults, their correlation with cognitive and neuropsychiatric symptoms, and the accuracy of dementia subtype diagnosis...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28117917/quantifying-the-accretion-of-hyperphosphorylated-tau-in-the-locus-coeruleus-and-dorsal-raphe-nucleus-the-pathological-building-blocks-of-early-alzheimer-s-disease
#17
A J Ehrenberg, A K Nguy, P Theofilas, S Dunlop, C K Suemoto, A T Di Lorenzo Alho, R P Leite, R Diehl Rodriguez, M B Mejia, U Rüb, J M Farfel, R E de Lucena Ferretti-Rebustini, C F Nascimento, R Nitrini, C A Pasquallucci, W Jacob-Filho, B Miller, W W Seeley, H Heinsen, L T Grinberg
AIMS: Hyperphosphorylated tau neuronal cytoplasmic inclusions (ht-NCI) are the best protein correlate of clinical decline in Alzheimer's disease (AD). Qualitative evidence identifies ht-NCI accumulating in the isodendritic core before the entorhinal cortex. Here, we used unbiased stereology to quantify ht-NCI burden in the locus coeruleus (LC) and dorsal raphe nucleus (DRN), aiming to characterize the impact of AD pathology in these nuclei with a focus on early stages. METHODS: We utilized unbiased stereology in a sample of 48 well-characterized subjects enriched for controls and early AD stages...
August 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28077386/hypertension-severity-is-associated-with-impaired-cognitive-performance
#18
Henrique C S Muela, Valeria A Costa-Hong, Mônica S Yassuda, Natália C Moraes, Claudia M Memória, Michel F Machado, Thiago A Macedo, Edson B S Shu, Ayrton R Massaro, Ricardo Nitrini, Alfredo J Mansur, Luiz A Bortolotto
BACKGROUND: Most evidence of target-organ damage in hypertension (HTN) is related to the kidneys and heart. Cerebrovascular and cognitive impairment are less well studied. Therefore, this study analyzed changes in cognitive function in patients with different stages of hypertension compared to nonhypertensive controls. METHODS AND RESULTS: In a cross-sectional study, 221 (71 normotensive and 150 hypertensive) patients were compared. Patients with hypertension were divided into 2 stages according to blood pressure (BP) levels or medication use (HTN-1: BP, 140-159/90-99 or use of 1 or 2 antihypertensive drugs; HTN-2: BP, ≥160/100 or use of ≥3 drugs)...
January 11, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28055136/factors-associated-with-brain-volume-in-major-depression-in-older-adults-without-dementia-results-from-a-large-autopsy-study
#19
Paula Villela Nunes, Claudia Kimie Suemoto, Renata Elaine Paraizo Leite, Renata Eloah de Lucena Ferretti-Rebustini, Carlos Augusto Pasqualucci, Ricardo Nitrini, Jose Marcelo Farfel, Katia Cristina de Oliveira, Lea Tenenholz Grinberg, Nicole Rezende da Costa, Camila Fernandes Nascimento, Faraz Salmasi, Helena Kyunghee Kim, Lionel Trevor Young, Wilson Jacob-Filho, Beny Lafer
OBJECTIVE: We examined brain volume and atrophy in individuals with major depressive disorder (MDD) without dementia that were referred to a large autopsy service. We also examined potential risk factors for brain atrophy, including demographics and clinical variables. METHODS: In this study, 1373 participants (787 male) aged 50 years or older who died from natural causes were included. Participants with no reliable informant, with cognitive impairment or dementia, with a medical history of severe chronic disease, or with prolonged agonal state were excluded...
January 5, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27901261/imaging-findings-in-faciobrachial-dystonic-seizures-associated-with-lgi-1-antibodies
#20
Ronnyson Susano Grativvol, Mateus Mistieri Simabukuro, Raphael Ribeiro Spera, Wagner Cid Palmeira Cavalcante, Hugo Henrique Soares Araújo, Daniel Sakuno, Leandro Tavares Lucato, Lécio Figueira Pinto, Luiz Henrique Martins Castro, Ricardo Nitrini
No abstract text is available yet for this article.
November 2016: Arquivos de Neuro-psiquiatria
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