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https://www.readbyqxmd.com/read/29734264/the-accuracy-of-ineco-frontal-screening-in-the-diagnosis-of-executive-dysfunction-in-frontotemporal-dementia-and-alzheimer-disease
#1
Valéria S Bahia, Mário A Cecchini, Luciana Cassimiro, Rene Viana, Thais B Lima-Silva, Leonardo Cruz de Souza, Viviane Amaral Carvalho, Henrique C Guimarães, Paulo Caramelli, Márcio L F Balthazar, Benito Damasceno, Sônia M D Brucki, Ricardo Nitrini, Mônica S Yassuda
INTRODUCTION: Executive dysfunction is a common symptom in neurodegenerative disorders and is in need of easy-to-apply screening tools that might identify it. The aims of the present study were to examine some of the psychometric characteristics of the Brazilian version of the INECO frontal screening (IFS), and to investigate its accuracy to diagnose executive dysfunction in dementia and its accuracy to differentiate Alzheimer disease (AD) from the behavioral variant of frontotemporal dementia (bvFTD)...
May 4, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29708208/apathy-and-functional-disability-in-behavioral-variant-frontotemporal-dementia
#2
Mônica S Yassuda, Thais B Lima da Silva, Claire M O'Connor, Shailaja Mekala, Suvarna Alladi, Valeria S Bahia, Viviane Almaral-Carvalho, Henrique C Guimaraes, Paulo Caramelli, Marcio L F Balthazar, Benito Damasceno, Sonia M D Brucki, Ricardo Nitrini, John R Hodges, Olivier Piguet, Eneida Mioshi
Background: Behavioral variant frontotemporal dementia (bvFTD) has profound consequences on patients and their families. In this multicenter study, we investigated the contribution of cognitive and neuropsychiatric factors to everyday function at different levels of overall functional impairment. Methods: In a retrospective cross-sectional study, 109 patients with bvFTD from 4 specialist frontotemporal dementia centers (Australia, England, India, and Brazil) were included...
April 2018: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29698251/effects-of-the-tailored-activity-program-in-brazil-tap-br-for-persons-with-dementia-a-randomized-pilot-trial
#3
Marcia M P C Novelli, Styfany C B Machado, Gabriela B Lima, Lais Cantatore, Barbara P Sena, Renata S Rodrigues, Camila I B Rodrigues, Mariana B F Canon, Catherine V Piersol, Ricardo Nitrini, Monica S Yassuda, Laura N Gitlin
OBJECTIVES: The objectives of this study were to evaluate the effects of the Tailored Activity Program-Brazilian version (TAP-BR), on behavioral symptoms and the quality of life (QOL) in persons with dementia, as well as on their caregivers, and on caregiver burden. MATERIALS AND METHODS: A 2-group randomized controlled trial with 30 dyads was conducted: the experimental group (n=15) received TAP-BR over 4 months, and a wait-list control group (n=15) received usual care...
April 25, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29494693/an-assessment-of-direct-and-indirect-costs-of-dementia-in-brazil
#4
Ceres Ferretti, Flávia M Sarti, Ricardo Nitrini, Fernando F Ferreira, Sonia M D Brucki
BACKGROUND: To analyze costs associated with dementia based on a cross-sectional study in the Brazilian health system. METHODS: Direct and indirect costs were estimated by conducting comprehensive interviews on the use of resources in a sample of 156 patients with dementia treated at an outpatient memory clinic of a tertiary hospital. A regression model was used to determine the main determinants of costs associated with dementia. RESULTS: Global costs of dementia were US$1,012...
2018: PloS One
https://www.readbyqxmd.com/read/29438114/validity-and-reliability-of-the-frontotemporal-dementia-rating-scale-ftd-frs-for-the-progression-and-staging-of-dementia-in-brazilian-patients
#5
Thaís B Lima-Silva, Valéria S Bahia, Mário A Cecchini, Luciana Cassimiro, Henrique C Guimarães, Leandro B Gambogi, Paulo Caramelli, Márcio Balthazar, Benito Damasceno, Sônia M D Brucki, Leonardo C de Souza, Ricardo Nitrini, Eneida Mioshi, Mônica S Yassuda
INTRODUCTION: Few studies on instruments for staging frontotemporal dementia (FTD) have been conducted. OBJECTIVE: The objective of this study was to analyze the factor structure, internal consistency, reliability, and convergent validity of the Brazilian version of the Frontotemporal Dementia Rating Scale (FTD-FRS). METHODS: A total of 97 individuals aged 40 years and above with >2 years' education took part in the study, 31 patients diagnosed with behavioral variant FTD (bvFTD), 8 patients with primary progressive aphasia, 28 with Alzheimer disease, 8 with mild cognitive impairment, and a control group of 22 healthy subjects...
February 13, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29438027/reader-response-diagnosis-and-management-of-dementia-with-lewy-bodies-fourth-consensus-report-of-the-dlb-consortium
#6
Jacy B Parmera, Sonia Brucki, Ricardo Nitrini
No abstract text is available yet for this article.
February 6, 2018: Neurology
https://www.readbyqxmd.com/read/29378909/intracranial-germinoma-causing-cerebral-haemiatrophy-and-hypopituitarism
#7
Bruno Fukelmann Guedes, Marcio Nattan Portes Souza, Breno José Alencar Pires Barbosa, Fernando Pereira Frassetto, Leandro Tavares Lucato, Carla Rachel Ono, Luiz Henrique Martins Castro, Ricardo Nitrini, Mateus Mistieri Simabukuro
A young woman presented with primary amenorrhoea, progressive haemiparesis, visual disturbance, dementia and focal motor seizures. Investigations showed hypopituitarism, unilateral cerebral atrophy and inflamed cerebrospinal fluid. A trans-sphenoidal biopsy gave a unifying diagnosis of a pituitary germinoma.
January 29, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29354221/association-between-diabetes-and-causes-of-dementia-evidence-from-a-clinicopathological-study
#8
Maria Niures Pimentel Dos Santos Matioli, Claudia Kimie Suemoto, Roberta Diehl Rodriguez, Daniela Souza Farias, Magnólia Moreira da Silva, Renata Elaine Paraizo Leite, Renata Eloah Lucena Ferretti-Rebustini, Carlos Augusto Pasqualucci, Wilson Jacob, Lea Tenenholz Grinberg, Ricardo Nitrini
Background: Diabetes mellitus is a risk factor for dementia, especially for vascular dementia (VaD), but there is no consensus on diabetes as a risk factor for Alzheimer's disease (AD) and other causes of dementia. Objective: To explore the association between diabetes and the neuropathological etiology of dementia in a large autopsy study. Methods: Data were collected from the participants of the Brain Bank of the Brazilian Aging Brain Study Group between 2004 and 2015...
October 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29354219/impact-of-hypertension-severity-on-arterial-stiffness-cerebral-vasoreactivity-and-cognitive-performance
#9
Henrique Cotchi Simbo Muela, Valeria A Costa-Hong, Monica Sanches Yassuda, Michel Ferreira Machado, Ricardo de Carvalho Nogueira, Natalia C Moraes, Claudia Maia Memória, Thiago A Macedo, Edson Bor-Seng-Shu, Ayrton Roberto Massaro, Ricardo Nitrini, Luiz A Bortolotto
Aging, hypertension (HTN), and other cardiovascular risk factors contribute to structural and functional changes of the arterial wall. Objective: To evaluate whether arterial stiffness (AS) is related to cerebral blood flow changes and its association with cognitive function in patients with hypertension. Methods: 211 patients (69 normotensive and 142 hypertensive) were included. Patients with hypertension were divided into 2 stages: HTN stage-1 and HTN stage-2...
October 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29305437/dementia-in-latin-america-assessing-the-present-and-envisioning-the-future
#10
REVIEW
Mario A Parra, Sandra Baez, Ricardo Allegri, Ricardo Nitrini, Francisco Lopera, Andrea Slachevsky, Nilton Custodio, David Lira, Olivier Piguet, Fiona Kumfor, David Huepe, Patricia Cogram, Thomas Bak, Facundo Manes, Agustin Ibanez
The demographic structure of Latin American countries (LAC) is fast approaching that of developing countries, and the predicted prevalence of dementia in the former already exceeds the latter. Dementia has been declared a global challenge, yet regions around the world show differences in both the nature and magnitude of such a challenge. This article provides evidence and insights on barriers which, if overcome, would enable the harmonization of strategies to tackle the dementia challenge in LAC. First, we analyze the lack of available epidemiologic data, the need for standardizing clinical practice and improving physician training, and the existing barriers regarding resources, culture, and stigmas...
January 30, 2018: Neurology
https://www.readbyqxmd.com/read/29303530/spine-magnetic-resonance-imaging-with-dynamic-flexion-sequences-for-evaluation-of-mini-polymyoclonus
#11
Ronnyson Susano Grativvol, Wagner Cid Palmeira Cavalcante, Vitor Marques Caldas, Gabriela Almeida Pimentel, Carlos Otto Heise, Leonardo Guilhermino Gutierrez, Leandro Tavares Lucato, Ricardo Nitrini
No abstract text is available yet for this article.
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29234599/selecting-the-most-relevant-brain-regions-to-discriminate-alzheimer-s-disease-patients-from-healthy-controls-using-multiple-kernel-learning-a-comparison-across-functional-and-structural-imaging-modalities-and-atlases
#12
Jane Maryam Rondina, Luiz Kobuti Ferreira, Fabio Luis de Souza Duran, Rodrigo Kubo, Carla Rachel Ono, Claudia Costa Leite, Jerusa Smid, Ricardo Nitrini, Carlos Alberto Buchpiguel, Geraldo F Busatto
Background: Machine learning techniques such as support vector machine (SVM) have been applied recently in order to accurately classify individuals with neuropsychiatric disorders such as Alzheimer's disease (AD) based on neuroimaging data. However, the multivariate nature of the SVM approach often precludes the identification of the brain regions that contribute most to classification accuracy. Multiple kernel learning (MKL) is a sparse machine learning method that allows the identification of the most relevant sources for the classification...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29213517/soccer-football-association-and-chronic-traumatic-encephalopathy-a-short-review-and-recommendation
#13
REVIEW
Ricardo Nitrini
Chronic traumatic encephalopathy (CTE) was initially described in boxers, but in recent years it has been reported in other settings, particularly in contact sports and military personnel. Soccer (football association) had previously been (and still is) considered relatively safe when compared to other sports, such as American football. However, a few cases of professional soccer players with CTE have been reported in the last few years. It is still unknown how frequent this condition is in soccer players, and the role played by heading the ball remains elusive...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213516/in-the-september-2017-issue
#14
EDITORIAL
Ricardo Nitrini
No abstract text is available yet for this article.
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213509/comparative-analysis-of-the-electroencephalogram-in-patients-with-alzheimer-s-disease-diffuse-axonal-injury-patients-and-healthy-controls-using-loreta-analysis
#15
Jéssica Natuline Ianof, Francisco José Fraga, Leonardo Alves Ferreira, Renato Teodoro Ramos, José Luiz Carlos Demario, Regina Baratho, Luís Fernando Hindi Basile, Ricardo Nitrini, Renato Anghinah
Alzheimer's disease (AD) is a dementia that affects a large contingent of the elderly population characterized by the presence of neurofibrillary tangles and senile plaques. Traumatic brain injury (TBI) is a non-degenerative injury caused by an external mechanical force. One of the main causes of TBI is diffuse axonal injury (DAI), promoted by acceleration-deceleration mechanisms. Objective: To understand the electroencephalographic differences in functional mechanisms between AD and DAI groups...
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213500/editorial-in-the-june-2017-issue
#16
EDITORIAL
Ricardo Nitrini
No abstract text is available yet for this article.
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213486/editorial-in-the-march-2017-issue
#17
EDITORIAL
Ricardo Nitrini
No abstract text is available yet for this article.
January 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29106057/higher-arterial-stiffness-is-associated-with-lower-cognitive-performance-in-patients-with-hypertension
#18
Henrique C S Muela, Valeria A Costa-Hong, Mônica S Yassuda, Natália C Moraes, Claudia M Memória, Michel F Machado, Edson Bor-Seng-Shu, Ricardo C Nogueira, Alfredo J Mansur, Ayrton R Massaro, Ricardo Nitrini, Thiago A Macedo, Luiz A Bortolotto
Cognitive impairment and elevated arterial stiffness have been described in patients with arterial hypertension, but their association has not been well studied. We evaluated the correlation of arterial stiffness and different cognitive domains in patients with hypertension compared with those with normotension. We evaluated 211 patients (69 with normotension and 142 with hypertension). Patients were age matched and distributed according to their blood pressure: normotension, hypertension stage 1, and hypertension stage 2...
January 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29031088/probing-the-correlation-of-neuronal-loss-neurofibrillary-tangles-and-cell-death-markers-across-the-alzheimer-s-disease-braak-stages-a-quantitative-study-in-humans
#19
Panos Theofilas, Alexander J Ehrenberg, Austin Nguy, Julia M Thackrey, Sara Dunlop, Maria B Mejia, Ana T Alho, Renata Elaine Paraizo Leite, Roberta Diehl Rodriguez, Claudia K Suemoto, Camila F Nascimento, Marcus Chin, Daniel Medina-Cleghorn, Ana Maria Cuervo, Michelle Arkin, William W Seeley, Bruce L Miller, Ricardo Nitrini, Carlos Augusto Pasqualucci, Wilson Jacob Filho, Udo Rueb, John Neuhaus, Helmut Heinsen, Lea T Grinberg
Clarifying the mechanisms connecting neurofibrillary tangle (NFT) neurotoxicity to neuronal dysfunction in humans is likely to be pivotal for developing effective treatments for Alzheimer's disease (AD). To model the temporal progression of AD in humans, we used a collection of brains with controls and individuals from each Braak stage to quantitatively investigate the correlation between intraneuronal caspase activation or macroautophagy markers, NFT burden, and neuronal loss, in the dorsal raphe nucleus and locus coeruleus, the earliest vulnerable areas to NFT accumulation...
January 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/28984587/diabetes-is-not-associated-with-alzheimer-s-disease-neuropathology
#20
Maria Niures Pimentel Dos Santos Matioli, Claudia Kimie Suemoto, Roberta Diehl Rodriguez, Daniela Souza Farias, Magnólia Moreira da Silva, Renata Elaine Paraizo Leite, Renata Eloah Lucena Ferretti-Rebustini, José Marcelo Farfel, Carlos Augusto Pasqualucci, Wilson Jacob Filho, Zoe Arvanitakis, Michel Satya Naslavsky, Mayana Zatz, Lea Tenenholz Grinberg, Ricardo Nitrini
BACKGROUND: Previous evidence linking diabetes to Alzheimer's disease (AD) neuropathology is mixed and scant data are available from low- and middle-income countries. OBJECTIVE: To investigate the association between diabetes and AD neuropathology in a large autopsy study of older Brazilian adults. METHODS: In this cross-sectional study, diabetes was defined by diagnosis during life or use of antidiabetic medication. A standardized neuropathological examination was performed using immunohistochemistry...
2017: Journal of Alzheimer's Disease: JAD
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