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https://www.readbyqxmd.com/read/29149402/structural-insights-into-tctp-and-its-interactions-with-ligands-and-proteins
#1
Nadine Assrir, Florian Malard, Ewen Lescop
The 19-24 kDa Translationally Controlled Tumor Protein (TCTP) is involved in a wide range of molecular interactions with biological and nonbiological partners of various chemical compositions such as proteins, peptides, nucleic acids, carbohydrates, or small molecules. TCTP is therefore an important and versatile binding platform. Many of these protein-protein interactions have been validated, albeit only few received an in-depth structural characterization. In this chapter, we will focus on the structural analysis of TCTP and we will review the available literature regarding its interaction network from a structural perspective...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/29149316/use-of-information-and-communication-technologies-in-the-formal-and-informal-health-system-responses-to-the-2015-nepal-earthquakes
#2
Olivia Crane, Julie Balen, Bhimsen Devkota, Sudha Ghimire, Simon Rushton
Information and Communication Technologies (ICTs) are increasingly recognized for their potential contributions to health service delivery in Low-and Middle-Income Countries (LMICs). As well as playing a role in improving the provision of health services under everyday 'normal' circumstances, ICTs can also be important in preparing for, mitigating, responding to and recovering from disasters. This research explores the use of ICTs in a natural disaster situation in Nepal, a country affected by a series of strong earthquakes in 2015...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29149312/who-are-more-responsive-mixed-methods-comparison-of-public-and-private-sector-physicians-in-rural-bangladesh
#3
Taufique Joarder, Asha George, Malabika Sarker, Saifuddin Ahmed, David H Peters
Responsiveness of physicians (ROPs) reflects the social actions by physicians to meet the legitimate expectations of health care users. Responsiveness is important since it improves understanding and care seeking by users, as well as fostering trust in health systems rather than replicating discrimination and entrenching inequality. Given widespread public and private sector health care provision in Bangladesh, we undertook a mixed-methods study comparing responsiveness of public and private physicians in rural Bangladesh...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29148087/an-agent-based-model-of-evolving-community-flood-risk
#4
Gina L Tonn, Seth D Guikema
Although individual behavior plays a major role in community flood risk, traditional flood risk models generally do not capture information on how community policies and individual decisions impact the evolution of flood risk over time. The purpose of this study is to improve the understanding of the temporal aspects of flood risk through a combined analysis of the behavioral, engineering, and physical hazard aspects of flood risk. Additionally, the study aims to develop a new modeling approach for integrating behavior, policy, flood hazards, and engineering interventions...
November 17, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29144298/flood-forecasting-within-urban-drainage-systems-using-narx-neural-network
#5
Yves Abou Rjeily, Oras Abbas, Marwan Sadek, Isam Shahrour, Fadi Hage Chehade
Urbanization activity and climate change increase the runoff volumes, and consequently the surcharge of the urban drainage systems (UDS). In addition, age and structural failures of these utilities limit their capacities, and thus generate hydraulic operation shortages, leading to flooding events. The large increase in floods within urban areas requires rapid actions from the UDS operators. The proactivity in taking the appropriate actions is a key element in applying efficient management and flood mitigation...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29143770/surface-relief-gratings-in-halogen-bonded-polymer-azobenzene-complexes-a-concentration-dependence-study
#6
Jelle E Stumpel, Marco Saccone, Valentina Dichiarante, Ossi Lehtonen, Matti Virkki, Pierangelo Metrangolo, Arri Priimagi
In recent years, supramolecular complexes comprising a poly(4-vinylpyridine) backbone and azobenzene-based halogen bond donors have emerged as a promising class of materials for the inscription of light-induced surface-relief gratings (SRGs). The studies up to date have focused on building supramolecular hierarchies, i.e., optimizing the polymer-azobenzene noncovalent interaction for efficient surface patterning. They have been conducted using systems with relatively low azobenzene content, and little is known about the concentration dependence of SRG formation in halogen-bonded polymer-azobenzene complexes...
October 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29143163/sex-prep-and-stigma-experiences-with-hiv-pre-exposure-prophylaxis-among-new-york-city-msm-participating-in-the-hptn-067-adapt-study
#7
Julie Franks, Yael Hirsch-Moverman, Avelino S Loquere, K Rivet Amico, Robert M Grant, Bonnie J Dye, Yan Rivera, Robert Gamboa, Sharon B Mannheimer
The HPTN 067/Alternative Dosing to Augment Pre-Exposure Prophylaxis Pill Taking (ADAPT) study evaluated daily and non-daily dosing schedules for oral pre-exposure prophylaxis (PrEP) to prevent HIV. A qualitative sub-study including focus groups and in-depth interviews was conducted among men who have sex with men participating in New York City to understand their experience with PrEP and study dosing schedules. The 37 sub-study participants were 68% black, 11% white, and 8% Asian; 27% were of Hispanic/Latino ethnicity...
November 15, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29142862/three-dimensional-printing-for-craniomaxillofacial-regeneration
#8
REVIEW
Laura Gaviria, Joseph J Pearson, Sergio A Montelongo, Teja Guda, Joo L Ong
Craniomaxillofacial injuries produce complex wound environments involving various tissue types and treatment strategies. In a clinical setting, care is taken to properly irrigate and stabilize the injury, while grafts are molded in an attempt to maintain physiological functionality and cosmesis. This often requires multiple surgeries and grafts leading to added discomfort, pain and financial burden. Many of these injuries can lead to disfigurement and resultant loss of system function including mastication, respiration, and articulation, and these can lead to acute and long-term psychological impact on the patient...
October 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29141535/sln-and-nlc-encapsulating-antifungal-agents-skin-drug-delivery-and-their-unexplored-potential-for-treating-onychomycosis
#9
Tais Gratieri, Anna Paula Krawczyk-Santos, Priscila Bianca Rodrigues da Rocha, Marcilio Cunha-Filho, Guilherme Martins Gelfuso, Ricardo Neves Marreto, Stephania Fleury Taveira
BACKGROUND: Lipid nanoparticles have been extensively studied for drug delivery of antifungal drugs, especially for dermatophytosis treatments. They can accumulate in skin appendages and release drugs in a controlled manner and also increase skin moisture, due to the formation of an occlusive film. Since moisture heavily influences nail and skin permeability, these systems seem to pose great potential for antifungal drug delivery. METHODS: We therefore compare skin and nail physiopathological structure and discuss the potential use of lipid nanoparticles in managing skin and nail mycoses, highlighting their unexplored use in onychomycosis...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29138533/comparison-of-visual-outcomes-after-bilateral-implantation-of-a-diffractive-trifocal-intraocular-lens-and-blended-implantation-of-an-extended-depth-of-focus-intraocular-lens-with-a-diffractive-bifocal-intraocular-lens
#10
André Lins de Medeiros, André Gustavo de Araújo Rolim, Antonio Francisco Pimenta Motta, Bruna Vieira Ventura, César Vilar, Mário Augusto Pereira Dias Chaves, Pedro Carlos Carricondo, Wilson Takashi Hida
Purpose: The purpose of this study was to compare the visual outcomes and subjective visual quality between bilateral implantation of a diffractive trifocal intraocular lens, Alcon Acrysof IQ(®) PanOptix(®) TNFT00 (group A), and blended implantation of an extended depth of focus lens, J&J Tecnis Symfony(®) ZXR00 with a diffractive bifocal intraocular lens, J&J Vision Tecnis(®) ZMB00 (group B). Methods: This prospective, nonrandomized, consecutive, comparative study included the assessment of 40 eyes in 20 patients implanted with multifocal intraocular lens...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29138307/microdiversity-of-an-abundant-terrestrial-bacterium-encompasses-extensive-variation-in-ecologically-relevant-traits
#11
Alexander B Chase, Ulas Karaoz, Eoin L Brodie, Zulema Gomez-Lunar, Adam C Martiny, Jennifer B H Martiny
Much genetic diversity within a bacterial community is likely obscured by microdiversity within operational taxonomic units (OTUs) defined by 16S rRNA gene sequences. However, it is unclear how variation within this microdiversity influences ecologically relevant traits. Here, we employ a multifaceted approach to investigate microdiversity within the dominant leaf litter bacterium, Curtobacterium, which comprises 7.8% of the bacterial community at a grassland site undergoing global change manipulations. We use cultured bacterial isolates to interpret metagenomic data, collected in situ over 2 years, together with lab-based physiological assays to determine the extent of trait variation within this abundant OTU...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29138209/healthcare-providers-gestational-weight-gain-counselling-practises-and-the-influence-of-knowledge-and-attitudes-a-cross-sectional-mixed-methods-study
#12
Jill Morris, Hara Nikolopoulos, Tanya Berry, Venu Jain, Michael Vallis, Helena Piccinini-Vallis, Rhonda C Bell
OBJECTIVE: To understand current gestational weight gain (GWG) counselling practices of healthcare providers, and the relationships between practices, knowledge and attitudes. DESIGN: Concurrent mixed methods with data integration: cross-sectional survey and semistructured interviews. PARTICIPANTS: Prenatal healthcare providers in Canada: general practitioners, obstetricians, midwives, nurse practitioners and registered nurses in primary care settings...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29138202/development-of-a-discussion-tool-to-enable-well-being-by-providing-choices-for-people-with-dementia-a-qualitative-study-incorporating-codesign-and-participatory-action-research
#13
Dianne Patricia Goeman, Marissa Dickins, Steve Iliffe, Dimity Pond, Fleur O'Keefe
OBJECTIVE: To codesign a discussion tool to facilitate negotiation of risk between health professionals, people with dementia and carers. METHODS: A qualitative approach using codesign. Thematic analysis was used to analyse interviews and focus groups with people with dementia, carers, healthcare staff and healthy older people exploring the issue of risk in dementia, the acceptability and development of a discussion tool. RESULTS: Sixty-one participants identified the breadth, depth and complexity of risk in dementia care and the need for individualised solutions...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29136658/community-ecology-in-3d-tensor-decomposition-reveals-spatio-temporal-dynamics-of-large-ecological-communities
#14
Romain Frelat, Martin Lindegren, Tim Spaanheden Denker, Jens Floeter, Heino O Fock, Camilla Sguotti, Moritz Stäbler, Saskia A Otto, Christian Möllmann
Understanding spatio-temporal dynamics of biotic communities containing large numbers of species is crucial to guide ecosystem management and conservation efforts. However, traditional approaches usually focus on studying community dynamics either in space or in time, often failing to fully account for interlinked spatio-temporal changes. In this study, we demonstrate and promote the use of tensor decomposition for disentangling spatio-temporal community dynamics in long-term monitoring data. Tensor decomposition builds on traditional multivariate statistics (e...
2017: PloS One
https://www.readbyqxmd.com/read/29134422/hiv-prevention-among-young-women-in-south-africa-understanding-multiple-layers-of-risk
#15
Christina Psaros, Cecilia Milford, Jennifer A Smit, Letitia Greener, Nzwakie Mosery, Lynn T Matthews, Abigail Harrison, Janna R Gordon, Matthew Mimiaga, David R Bangsberg, Steven A Safren
Despite concerted prevention efforts, young South African women remain at the epicenter of the HIV epidemic. Although these women have grown up in a community powerfully affected by HIV, systematic investigation into how this "second generation" of HIV-affected youth navigates HIV risk is lacking. This study qualitatively explored a complex interplay of factors influencing HIV risk among young pregnant women in KwaZulu-Natal, South Africa. We conducted in-depth interviews with 35 pregnant women (22 HIV-uninfected and 13 HIV-infected) aged 18-21, 18 healthcare providers, and focus groups with 19 community stakeholders...
November 13, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29134341/universit%C3%A3-tsspital-z%C3%A3-rich-80-years-of-neurosurgical-patient-care-in-switzerland
#16
Martin N Stienen, Carlo Serra, Lennart H Stieglitz, Niklaus Krayenbühl, Oliver Bozinov, Luca Regli
BACKGROUND: The predecessor of today's Department of Neurosurgery, UniversitätsSpital Zürich (USZ), was founded 80 years ago as the first independent Swiss clinic dedicated to neurosurgical patient care. On the occasion of this anniversary, we aimed to highlight the history of neurosurgery as a specialty at the USZ, and to put it into the historical context of Swiss and European Neurosurgery. METHOD: A literature review was conducted and we searched the archives of the USZ and the city of Zurich, as well as those of Swiss journals to extract relevant published articles, books, historical reports and pictures...
November 13, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29134069/engaging-rural-australian-communities-in-national-science-week-helps-increase-visibility-for-women-researchers
#17
Margaret C Hardy, Mathilde R Desselle
During a week-long celebration of science, run under the federally supported National Science Week umbrella, the Catch a Rising Star: women in Queensland research (CaRS) programme flew scientists who identify as women to nine regional and remote communities in the Australian State of Queensland. The aim of the project was twofold: first, to bring science to remote and regional communities in a large, economically diverse state; and second, to determine whether media and public engagement provides career advancement opportunities for women scientists...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29132721/endocrine-pathology-past-present-and-future
#18
REVIEW
Sylvia L Asa, Ozgur Mete
Endocrine pathology is the subspecialty of diagnostic pathology which deals with the diagnosis and characterisation of neoplastic and non-neoplastic diseases of the endocrine system. This relatively young subspecialty was initially focused mainly on thyroid and parathyroid pathology, with some participants also involved in studies of the pituitary, the endocrine pancreas, and the adrenal glands. However, the endocrine system involves much more than these traditional endocrine organs and the discipline has grown to encompass lesions of the dispersed neuroendocrine cells, including neuroendocrine tumours (NETs) of the lungs, gastrointestinal tract, thymus, breast and prostate, as well as paraganglia throughout the body, not just in the adrenals...
November 10, 2017: Pathology
https://www.readbyqxmd.com/read/29132373/understanding-malaria-treatment-seeking-preferences-within-the-public-sector-amongst-mobile-migrant-workers-in-a-malaria-elimination-scenario-a-mixed-methods-study
#19
Aung Ye Naung Win, Thae Maung Maung, Khin Thet Wai, Tin Oo, Aung Thi, Rungrawee Tipmontree, Ngamphol Soonthornworasiri, Mondha Kengganpanich, Jaranit Kaewkungwal
BACKGROUND: Migration flows and the emerging resistance to artemisinin-based combination therapy in the Greater Mekong Sub-region (GMS) create programmatic challenges to meeting the AD 2030 malaria elimination target in Myanmar. The National Malaria Control Programme (NMCP) targeted migrant workers based mainly on the stability of their worksites (categories 1: permanent work-setting; categories 2 and 3: less stable work-settings). This study aims to assess the migration patterns, malaria treatment-seeking preferences, and challenges encountered by mobile/migrant workers at remote sites in a malaria-elimination setting...
November 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29132364/-i-m-not-strong-enough-i-m-not-good-enough-i-can-t-do-this-i-m-failing-a-qualitative-study-of-low-socioeconomic-status-smokers-experiences-with-accesssing-cessation-support-and-the-role-for-alternative-technology-based-support
#20
Veronica C Boland, Richard P Mattick, Hayden McRobbie, Mohammad Siahpush, Ryan J Courtney
BACKGROUND: The social gradient in smoking rates persist with an overrepresentation of smoking and its associated harms concentrated within lower socioeconomic status (SES) populations. Low-SES smokers are motivated to quit but face multiple barriers when engaging a quit attempt. An understanding of the current treatment service model from the perspectives of treatment-seeking low-SES smokers is needed to inform the design of alternative smoking cessation support services tailored to the needs of low-SES populations...
November 13, 2017: International Journal for Equity in Health
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