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https://www.readbyqxmd.com/read/28439849/aortic-valve-replacement-after-coronary-artery-bypass-grafting-with-the-in-situ-right-gastroepiploic-artery-to-the-occluded-right-coronary-artery-using-a-temporary-vein-graft-for-cardioplegia
#1
Yoshifumi Fuke, Toru Yasutsune, Masato Sakamoto
BACKGROUND: The operation of aortic valve replacement (AVR) after CABG is a technically challenging procedure in respect to dissection of living grafts from its surrounding tissue, myocardial protection, and so on, especially that procedure to patients with living in situ functional arterial grafts to occluded native coronary arteries has a special problem in regard to myocardial protection because myocardial blood supply originates from various arteries including the left internal thoracic artery (LITA), the right internal thoracic artery (RITA), and the right gastroepiploic artery (GEA); hence, adequate myocardial protection should be fastidiously considered...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28439213/a-clinical-perspective-on-the-utility-of-alpha-1-antichymotrypsin-for-the-early-diagnosis-of-calcific-aortic-stenosis
#2
Tatiana Martin-Rojas, Laura Mourino-Alvarez, Felix Gil-Dones, Fernando de la Cuesta, Esther Rosello-Lleti, Carlos M Laborde, Miguel Rivera, Luis Fernando Lopez-Almodovar, Juan Antonio Lopez, Finn Akerstrom, Luis R Padial, Maria G Barderas
BACKGROUND: Calcific aortic stenosis (CAS) is the most common heart valve disease in the elderly, representing an important economic and social burden in developed countries. Currently, there is no way to predict either the onset or progression of CAS, emphasizing the need to identify useful biomarkers for this condition. METHODS: We performed a multi-proteomic analysis on different kinds of samples from CAS patients and healthy donors: tissue, secretome and plasma...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28438736/altered-microrna-expression-is-responsible-for-the-pro-osteogenic-phenotype-of-interstitial-cells-in-calcified-human-aortic-valves
#3
Rui Song, David A Fullerton, Lihua Ao, Ke-Seng Zhao, T Brett Reece, Joseph C Cleveland, Xianzhong Meng
BACKGROUND: The transition of aortic valve interstitial cells (AVICs) to myofibroblastic and osteoblast-like phenotypes plays a critical role in calcific aortic valve disease progression. Several microRNAs (miRs) are implicated in stem cell differentiation into osteoblast. We hypothesized that an epigenetic mechanism regulates valvular pro-osteogenic activity. This study examined miR profile in AVICs of calcified valves and identified miRs responsible for AVIC phenotypic transition. METHODS AND RESULTS: AVICs were isolated from normal and diseased valves...
April 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28435302/in-situ-detection-of-chlamydia-pneumoniae-c-trachomatis-and-cytokines-among-cardiovascular-diseased-patients-from-the-amazon-region-of-brazil
#4
Larissa S Freitas, Núbia Caroline C Almeida, Maria Alice Freitas Queiroz, Marcelo M Zaninotto, Hellen T Fuzii, Alfredo Ribeiro-Silva, Antonio Cr Vallinoto, Marluísa Og Ishak, Juarez As Quaresma, Ricardo Ishak
BACKGROUND: Chronic coronary artery disease has been associated, as a consequence of the local inflammatory reaction with previous or persistent infection with Chlamydia pneumoniae, which led to the investigation of the association of cardiovascular disease and previous infection with C. trachomatis and the role of cytokine profile (in situ) markers in the vascular system tissues. METHODS: Sixty-nine biopsies were collected for immunohistochemical analysis for the presence of IL-6, IL-8, TNF-α, IFN-γ, TGF-β, and IL-10, in 16 fragments from atheromatous plaques, 32 aorta fragments, and 21 valve fragments, using a tissue microarray technique for paraffin embedded tissues...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28432006/stepwise-use-of-circulatory-support-devices-in-a-patient-refractory-to-cardiopulmonary-resuscitation
#5
Marco Spartera, Richard J Jabbour, Mauro Chiarito, Michele De Bonis, Federico Pappalardo
This case describes the management of a patient admitted to an emergency department with general malaise, who deteriorated into cardiac arrest and refractory to advanced life support measures. After extracorporeal cardiopulmonary resuscitation (eCPR) with veno-arterial extracorporeal membrane oxygenation in association with an Impella 2.5 device, the patient underwent cardiac surgery (tissue aortic valve replacement, coronary artery bypass grafting and implantation of short-term paracorporeal left ventricular assist device)...
April 8, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28431214/interferon-%C3%AE-released-by-activated-cd8-t-lymphocytes-impairs-the-calcium-resorption-potential-of-osteoclasts-in-calcified-human-aortic-valves
#6
Edit Nagy, Yang Lei, Eduardo Martínez-Martínez, Simon C Body, Florian Schlotter, Michael Creager, Alexander Assmann, Kamal Khabbaz, Peter Libby, Göran K Hansson, Elena Aikawa
Calcium content in patients with calcific aortic valve disease (CAVD) correlates with the severity of stenosis. In CAVD, activated T lymphocytes localize with osteoclast regions; however, the functional consequences of this association remain unknown. We hypothesized that CD8(+) T cells modulate calcification in CAVD. Explanted CAVD valves (n = 52) dissected into noncalcified and calcified portions were subjected to mRNA extraction, real-time quantitative PCR, enzyme-linked immunosorbent assay, and immunohistochemical analyses...
April 18, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28429692/pulmonary-artery-and-right-ventricle-function-in-patients-with-bicuspid-aortic-valve
#7
Çetin Geçmen, Gamze Babür Güler, Suzan Hatipoğlu, Muzaffer Kahyaoğlu, Murat Çap, Servet İzci, Çağatay Önal, Emrah Erdoğan, Aykun Hakgör, Özkan Candan, Arzu Kalaycı, Tuba Unkun, İbrahim Akın İzgi
OBJECTIVE: Bicuspid aortic valve (BAV) is a complex developmental anomaly caused by abnormal aortic leaflet formation during valvulogenesis. The present study is an assessment of the effects of BAV disease on the ascending aorta and pulmonary artery (PA), and an evaluation of the consequences for systolic and diastolic functioning of the left and right ventricles. METHODS: Total of 66 patients were eligible for inclusion. Pulmonary artery maximum diameter (PAD) was obtained 1 cm distal to the pulmonary annulus...
April 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28429161/on-the-in-vivo-function-of-the-mitral-heart-valve-leaflet-insights-into-tissue-interstitial-cell-biomechanical-coupling
#8
Chung-Hao Lee, Will Zhang, Kristen Feaver, Robert C Gorman, Joseph H Gorman, Michael S Sacks
There continues to be a critical need for developing data-informed computational modeling techniques that enable systematic evaluations of mitral valve (MV) function. This is important for a better understanding of MV organ-level biomechanical performance, in vivo functional tissue stresses, and the biosynthetic responses of MV interstitial cells (MVICs) in the normal, pathophysiological, and surgically repaired states. In the present study, we utilized extant ovine MV population-averaged 3D fiducial marker data to quantify the MV anterior leaflet (MVAL) deformations in various kinematic states...
April 20, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28420669/a-possible-early-biomarker-for-bicuspid-aortopathy-circulating-transforming-growth-factor-beta-1-to-soluble-endoglin-ratio
#9
Amalia Forte, Ciro Bancone, Gilda Cobellis, Marianna Buonocore, Giuseppe Santarpino, Theodor Fischlein, Marilena Cipollaro, Marisa De Feo, Alessandro Della Corte
Rationale: The pathogenesis of bicuspid aortic valve (BAV)-associated aortopathy is poorly understood and no prognostic biomarker is currently available. Objective: We aimed to identify putative circulating biomarkers pathogenetically and prognostically linked to bicuspid aortopathy. Methods and Results: By RT-PCR, we evaluated gene expression variations (versus normal aorta) of transforming growth factor-beta1 (TGF-β1), connective tissue growth factor (CTGF), matrix metalloproteinase-2 (MMP-2), MMP-14, endoglin (ENG) and superoxide dismutase 3 (SOD3) in ascending aorta samples from 50 tricuspid and 70 BAV patients undergoing surgery for aortic stenosis (aorta diameter ≤45mm: BAVnon-dil or >45mm: BAVdil)...
April 18, 2017: Circulation Research
https://www.readbyqxmd.com/read/28416589/multimodality-imaging-of-the-tricuspid-valve-with-implication-for-percutaneous-repair-approaches
#10
REVIEW
Francesco Ancona, Stefano Stella, Maurizio Taramasso, Claudia Marini, Azeem Latib, Paolo Denti, Francesco Grigioni, Maurice Enriquez-Sarano, Ottavio Alfieri, Antonio Colombo, Francesco Maisano, Eustachio Agricola
Nowadays some percutaneous options for tricuspid valve (TV) repair are available: Tricinch (4Tech Cardio, Galway, Ireland) mimicking the Kay procedure, Trialign (Mitralign, Boston, MA, USA) aiming to bicuspidise TV, MitraClip (Abbott Vascular, Abbott Park, Illinois, USA) mimicking Alfieri's stitch, direct transcatheter annuloplasty with Cardioband (Valtech Cardio, Or Yehuda, Israel) and transcatheter Forma Repair (Edwards Lifesciences, Irvine, California, USA) providing a surface for leaflet coaptation. A multimodality imaging approach is fundamental for defining the pathophysiology of tricuspid regurgitation (TR), preprocedural planning and intraprocedural monitoring...
April 17, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28415122/p1138cardiac-shear-wave-velocity-in-healthy-individuals
#11
M Strachinaru, M L Geleijnse, J G Bosch, N De Jong, Afw Van Der Steen, B M Van Dalen, H J Vos
Background: The closure of the valves generates shear waves in the heart walls. The propagation velocity of shear waves relates to stiffness. This could potentially be used to estimate the stiffness of the myocardium, with huge potential implications in pathologies characterized by a deterioration of the diastolic properties of the left ventricle. In an earlier phantom study we already validated shear wave tracking with a clinical ultrasound system in cardiac mode. Purpose: In this study we aimed to measure the shear waves velocity in normal individuals...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28415102/p650influence-of-fetunin-a-level-on-progression-of-calcific-aortic-valve-stenosis-the-cofrasa-generac-study
#12
N Kubota, Dmz David Messika-Zeitoun
Background.: In recent years, pathophysiology of aortic stenosis (AS) has been considered as a possibly active inflammatory process, but its determinants remain unclear. Calcium tissue deposition observed in dilaysis patients have been linked to low level of Fetuin-A, a powerful inhibitor of ectopic calcification. It is thus suspected to play a role in development of aortic stenosis. Purpose.: To assess correlation between Fetuin-A level and AS progression in a prospective cohort of AS patients, COFRASA (clinicalTrial...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28413185/comparison-of-the-long-term-outcomes-of-mechanical-and-bioprosthetic-aortic-valves%C3%A3-a-propensity-score-analysis
#13
Kenji Minakata, Shiro Tanaka, Nobushige Tamura, Shigeki Yanagi, Yohei Ohkawa, Shuichi Okonogi, Tatsuo Kaneko, Akihiko Usui, Tomonobu Abe, Mitsuomi Shimamoto, Yoshiharu Takahara, Kazuo Yamanaka, Hitoshi Yaku, Ryuzo Sakata
BACKGROUND: The aim of this study was to assess the long-term outcomes of aortic valve replacement (AVR) with either mechanical or bioprosthetic valves according to age at operation.Methods and Results:A total of 1,002 patients (527 mechanical valves and 475 bioprosthetic valves) undergoing first-time AVR were categorized according to age at operation: group Y, age <60 years; group M, age 60–69 years; and group O, age ≥70 years). Outcomes were compared on propensity score analysis (adjusted for 28 variables)...
April 12, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28413031/matrix-metalloproteinases-in-remodeling-of-lower-extremity-veins-and-chronic-venous-disease
#14
Yunfei Chen, Wei Peng, Joseph D Raffetto, Raouf A Khalil
The veins of the lower extremity are equipped with efficient wall, contractile vascular smooth muscle (VSM), and competent valves in order to withstand the high venous hydrostatic pressure in the lower limb and allow unidirectional movement of deoxygenated blood toward the heart. The vein wall structure and function are in part regulated by matrix metalloproteinases (MMPs). MMPs are zinc-dependent endopeptidases that are secreted as inactive pro-MMPs by different cells in the venous wall including fibroblasts, VSM, and leukocytes...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/28409155/preservation-of-myocardial-perfusion-and-function-by-keeping-hypertrophied-heart-empty-and-beating-for-valve-surgery-an-in-vivo-mr-study-of-pig-hearts
#15
Jian Wang, Bo Xiang, Jixian Deng, Hung-Yu Lin, Darren H Freed, Rakesh C Arora, Ganghong Tian
Objectives. Normothermic hyperkalemic cardioplegia arrest (NHCA) may not effectively preserve hypertrophied myocardium during open-heart surgery. Normothermic normokalemic beating perfusion (NNBP), keeping hearts empty-beating, was utilized as an alternative to evaluate its cardioprotective role. Materials and Methods. Twelve hypertrophied pig hearts at 58.6 ± 7.2 days after ascending aorta banding underwent NNBP and NHCA, respectively. Near infrared myocardial perfusion imaging with indocyanine green (ICG) was conducted to assess myocardial perfusion...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28406475/depletion-of-polycomb-repressive-complex-2-core-component-eed-impairs-fetal-hematopoiesis
#16
Wenhua Yu, Fang Zhang, Shiyan Wang, Yi Fu, Jiahuan Chen, Xiaodong Liang, Huangying Le, William T Pu, Bing Zhang
Polycomb repressive complex 2 (PRC2), a H3K27me3 methyltransferase complex, promotes the development of many organs by silencing ectopic transcription program. However, currently little is known about the role of PRC2 in blood and vascular development. In this study, we interrogated the function of embryonic ectoderm development (EED), a core PRC2 component, in both endothelial and hematopoietic tissues by inactivating a floxed murine EED allele with Tie2Cre, which catalyzes recombination in endothelial and hematopoietic lineages...
April 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28402044/reported-normal-values-and-weighted-means-for-commonly-used-echocardiography-pulsed-doppler-and-tissue-doppler-measurements
#17
REVIEW
Magnus Dencker, Martin Stagmo
Pulsed Doppler (PW) and tissue Doppler imaging (TDI) measurements are part of every echocardiography examination for evaluation of left ventricular (LV) diastolic function and filling pressure. The purpose of this study was to summarize published data on normal values for PW and TDI measurements. A PubMed search was performed on the 10th of October 2016 to identify relevant articles. Studies were considered relevant if they included more than 200 healthy individuals. A total of 13 studies were identified. Of these, 13 studies with 7777 subjects reported PW measurement over the mitral valve, six studies with 4082 subjects reported PW measurement in the pulmonary vein and 10 studies with 5988 subjects reported TDI...
April 12, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28401685/characterization-of-new-bone-morphogenetic-protein-bmp-2-regulatory-alleles
#18
Tapan A Shah, Youhua Zhu, Nadia N Shaikh, Marie A Harris, Stephen E Harris, Melissa B Rogers
Bone morphogenetic protein 2 (BMP2, HGNC:1069, GeneID: 650) is a classical morphogen; a molecule that acts at a distance and whose concentration influences cell proliferation, differentiation, and apoptosis. Key events requiring precise Bmp2 regulation include heart specification and morphogenesis and neural development. In mesenchymal cells, the concentration of BMP2 influences myogenesis, adipogenesis, chondrogenesis, and osteogenesis. Because the amount, timing, and location of BMP2 synthesis influence pattern formation and organogenesis, the mechanisms that regulate Bmp2 are crucial...
April 12, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28401248/-nasal-turbinate-surgery
#19
F Sommer, J Lindemann, M-O Scheithauer, T K Hoffmann, J A Veit
The nose forms the first 8 cm of the upper respiratory tract and is responsible for cleansing, humidification, and temperature control of the supplied air. This is also referred to as conditioning. The nasal valve region, formed by the head of the lower nasal concha, portions of the cartilaginous septum, and the upper lateral cartilage, is responsible for diffusing and accelerating the respiratory airflow. Prerequisite are regular mucociliary clearance and sufficient air passage. Hypertrophy of the lower nasal turbinate is one of the most common causes of symptomatic nasal congestion...
April 11, 2017: HNO
https://www.readbyqxmd.com/read/28400931/evaluation-of-cardiac-functions-in-children-and-adolescents-with-type-1-diabetes
#20
Faten M Abd-El Aziz, Shereen Abdelghaffar, Eman M Hussien, Aya M Fattouh
BACKGROUND: Cardiac dysfunction in patients with type 1 diabetes (T1D) represents one of the serious complications. To evaluate the cardiac function in children with T1D by conventional echocardiography and tissue Doppler imaging (TDI). METHODS: The study included 40 T1D patients (age between 6 and 16 years) with > 5 years duration of diabetes and 42 healthy control children. The patients were subjected to clinical evaluation and laboratory investigations [glycosylated hemoglobin A1c (HbA1c), serum lipids and lipoproteins]...
March 2017: Journal of Cardiovascular Ultrasound
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