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https://www.readbyqxmd.com/read/29777281/right-ventricular-systolic-function-parameters-in-hypoplastic-left-heart-syndrome
#1
S Javed Zaidi, Jamie Penk, Vivian W Cui, Supaluck Kanjanauthai, David A Roberson
Assessment of the systolic function of the right ventricle (RV) in patients with hypoplastic left heart syndrome (HLHS) is important. The asymmetric shape and heavy trabeculations make accurate assessment of RV systolic function challenging. Novel measures of RV function could be helpful in distinguishing reduced versus preserved function in HLHS and may also be worse in HLHS with preserved function compared to normal controls. These novel methods offer promise, but research and clinical applicability is hindered as no cut-off values for normal function have been established...
May 18, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29776289/in-situ-heart-valve-tissue-engineering-using-the-innate-immune-response-to-do-the-hard-work
#2
EDITORIAL
Farhan Zafar, David L S Morales
No abstract text is available yet for this article.
June 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29774187/multimodality-imaging-for-the-quantitative-assessment-of-mitral-regurgitation
#3
REVIEW
Pei G Chew, Katrina Bounford, Sven Plein, Dominik Schlosshan, John P Greenwood
The natural history of mitral regurgitation (MR) results in significant morbidity and mortality. Innovations in non-invasive imaging have provided new insights into the pathophysiology and quantification of MR, in addition to early detection of left ventricular (LV) dysfunction and prognostic assessment in asymptomatic patients. Transthoracic (TTE) and transesophageal (TOE) echocardiography are the mainstay for diagnosis, assessment and serial surveillance. However, the advance from 2D to 3D imaging leads to improved assessment and characterization of mitral valve (MV) disease...
April 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29770299/regenerative-medicine-therapy-for-single-ventricle-congenital-heart-disease
#4
REVIEW
Chetan Ambastha, Gregory J Bittle, David Morales, Nathaniel Parchment, Progyaparamita Saha, Rachana Mishra, Sudhish Sharma, Alexander Vasilenko, Muthukumar Gunasekaran, Manal T Al-Suqi, Deqiang Li, Peixin Yang, Sunjay Kaushal
One of the most complex forms of congenital heart disease (CHD) involving single ventricle physiology is hypoplastic left heart syndrome (HLHS), characterized by underdevelopment of the left ventricle (LV), mitral and aortic valves, and narrowing of the ascending aorta. The underdeveloped LV is incapable of providing long-term systemic flow, and if left untreated, the condition is fatal. Current treatment for this condition consists of three consecutive staged palliative operations: the first is conducted within the first few weeks of birth, the second between 4 to 6 months, and the third and final surgery within the first 4 years...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29769587/explorations-on-the-ecological-role-of-toxin-secretion-and-delivery-in-jawless-predatory-polychaeta
#5
N Cuevas, M Martins, A P Rodrigo, C Martins, P M Costa
Motivated by biotechnological prospects, there is increasing evidence that we may just be scraping the tip of the iceberg of poisonous marine invertebrates, among which the Polychaeta are promising candidates for bioprospecting. Here we show that an inconspicuous phyllodocid uses toxins in its uncanny feeding strategy. The worm, a jawless active predator characterised by its bright green colour, preys on larger invertebrates (including conspecifics) by extracting tissue portions with its powerful proboscis through suction...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29762936/bentall%C3%A2-s-procedure-in-pediatric-mixed-connective-tissue-disease-syndrome-management-of-pediatric-aortic-aneurysm-a-brief-review
#6
Krithika Ramaprabhu, Om Prakash, Noveen Davidson, Sanjay Bhalero, Satish Radhakrishnan, Robert Coelho
Mixed connective tissue disease (MCTD) syndrome in children may lead to large aortic aneurysms, which in turn pose a difficult surgical problem. Valve-sparing root replacement is not always a viable option as the disease process invariably affects the aortic valve leaflets. Among pediatric patients, the Ross procedure is contraindicated on account of weakness of the pulmonary root, while Bentall surgery is the 'gold standard' treatment of aortic aneurysm, with reproducible and excellent long-term results. The case is presented of a three-year-old girl with a large thoracic aortic aneurysm in whom Bentall's surgery was performed, with a good result...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29757467/severe-tricuspid-regurgitation-due-to-interactions-with-right-ventricular-permanent-pacemaker-or-defibrillator-leads
#7
REVIEW
Cory R Trankle, Zachary M Gertz, Jayanthi N Koneru, Vigneshwar Kasirajan, Patricia Nicolato, Hem Bhardwaj, Kenneth A Ellenbogen, Gautham Kalahasty
Although thought to be a rare event, permanent pacemakers and implantable cardioverter-defibrillators with right ventricular intracardiac leads have the potential to induce tricuspid valve dysfunction. Adverse lead-valve interactions can take place through a variety of mechanisms including damage at the time of implantation, leaflet pinning, or long-term fibrosis encapsulating the leaflet tissue. Clinical manifestations can display a wide range of severity, as well as a highly variable time span between implantation and hemodynamic deterioration...
May 14, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29755630/echocardiographic-features-in-bartonella-endocarditis-a-case-series
#8
Orathai Pachirat, Sompop Prathanee, George Watt
Bartonella spp. are emerging pathogens that are reported as the cause of blood culture-negative endocarditis ( BCNE). However, echocardiographic features and assessment of this endocarditis remains unclear. Four patients with B. henselae endocarditis were identified. All patients had underlying cardiac conditions: rheumatic heart disease in three, congenital heart disease in one. Evidence of vegetations was found on the aortic valve in all patients with large, highly mobile vegetations and severely destroyed valves demonstrated by the transthoracic echocardiogram leading to severe aortic regurgitation and heart failure...
April 2018: Cardiology Research
https://www.readbyqxmd.com/read/29755090/-successful-surgical-repair-of-the-aortic-annular-infective-endocarditis-with-subvalvular-abscess-report-of-a-case
#9
Manabu Shiraishi, Daigo Shinoda, Nobu Yokoyama, Satoshi Itoh
A 49-year-old female was admitted to our hospital with a history of fever for 2 weeks and consciousness disorder.Transthoracic echocardiography demonstrated aortic regurgitation with a mobile fibrous band adhering to the right cusp. Infective endocarditis was diagnosed by positive blood culture and echocardiographic findings. Emergent aortic valve surgery was performed because of uncontrollable infection. A destroyed aortic annulus and subvalvular abscess was found during the operation. Removal of abscess tissue and annuloplasty with self-pericardium were successfully performed...
May 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29755084/-further-surgery-for-mitral-stenosis-12-years-after-mitral-valve-repair-report-of-a-case
#10
Naohiro Shimada, Takashi Ueda, Noriyuki Hatanaka, Hiroyuki Yamada
A rare case of mitral stenosis after mitral valve repair for non-rheumatic mitral regurgitation is presented. An 81-year-old woman who had undergone mitral valve repair using an annuloplasty ring 12 years earlier, was referred to our hospital because of dyspnea during exertion. As echocardiography revealed severe mitral stenosis, and redo surgery was carried out. During the surgery, fibrous tissue covered the annuloplasty ring and extended onto both leaflets of the mitral valve, which narrowed its orifice, by rendering the leaflets stiff and immobile...
May 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29753455/effect-of-severe-bioprosthetic-valve-tissue-ingrowth-and-inflow-calcification-on-valve-in-valve-performance
#11
Hoda Hatoum, Jennifer Dollery, Scott M Lilly, Juan A Crestanello, Lakshmi Prasad Dasi
While in vivo studies clearly demonstrate that supra-annular Valve-in-Valve (ViV) implantation provides the highest probability for optimal post-ViV pressure gradients (PG), there is still no physical insight into explaining anomalies where some supra-annular ViV implantations yield high pressure gradients while some sub-annular implantations yield low pressure gradients. The aim of this study is to explain how severe tissue ingrowth and calcification (TIC) in a surgical aortic valve (SAV) can be one physical mechanism leading to anomalous ViV performance characteristic...
May 4, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29752279/a-comprehensive-study-of-calcific-aortic-stenosis-from-rabbit-to-human-samples
#12
L Mourino-Alvarez, M Baldan-Martin, T Sastre-Oliva, M Martin-Lorenzo, A S Maroto, N Corbacho-Alonso, R Rincon, T Martin-Rojas, L F Lopez-Almodovar, G Alvarez-Llamas, F Vivanco, L R Padial, F de la Cuesta, M G Barderas
The global incidence of calcific aortic stenosis (CAS) is increasing due, in part, to a growing elderly population, and poses a great challenge to public health because of the multiple comorbidities of these patients. Using a rabbit model of CAS, we sought to characterize protein alterations associated with calcified valve tissue that can be ultimately measured in plasma as non-invasive biomarkers of CAS.Aortic valves from healthy and mild stenotic rabbits were analyzed by two-dimensional difference gel electrophoresis, and selected reaction monitoring was used to directly measure the differentially expressed proteins in plasma from the same rabbits to corroborate their potential as diagnostic indicators, and also in plasma from human subjects, to examine their translatability to the clinical setting...
May 10, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29749108/biomaterial-characterization-of-off-the-shelf-decellularized-porcine-pericardial-tissue-for-use-in-prosthetic-valvular-applications
#13
Joshua A Choe, Soumen Jana, Brandon J Tefft, Ryan S Hennessy, Jason Go, David Morse, Amir Lerman, Melissa D Young
Fixed pericardial tissue is commonly used for commercially available xenograft valve implants, and has proven durability, but lacks the capability to remodel and grow. Decellularized porcine pericardial tissue has the promise to outperform fixed tissue and remodel, but the decellularization process has been shown to damage the collagen structure and reduce mechanical integrity of the tissue. Therefore, a comparison of uniaxial tensile properties was performed on decellularized, decellularized-sterilized, fixed, and native porcine pericardial tissue, versus native valve leaflet cusps...
May 10, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29748714/morphological-and-molecular-analyses-of-bipteria-lusitanica-n-sp-in-wild-white-seabream-diplodus-sargus-linnaeus-1758-in-portugal
#14
Caner Sirin, Maria J Santos, Luis F Rangel
The present study records the presence of Bipteria lusitanica n. sp. in wild white seabream, Diplodus sargus (Linnaeus, 1758) off the Portuguese coast. Myxosporean parasites were found in the interstitial tissue of kidney and free in urinary bladder of D. sargus with a 33.3% of prevalence of infection. Myxospores were triangular or inversely pyramidal in shape and anteriorly wider in frontal view, measuring 11.2 ± 1.0 μm in length, 12.6 ± 0.9 μm in width, and 11.6 ± 0.4 μm in thickness. The sinuous sutural line was parallel to the axis that connects the center of the two polar capsules...
May 11, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29748157/interleukin-32-plays-an-essential-role-in-human-calcified-aortic-valve-cells
#15
Chung-Lin Tsai, Ying-Ming Chiu, Yi-Ju Lee, Chin-Tung Hsieh, Dong-Chen Shieh, Gregory J Tsay, Da-Tian Bau, Yi-Ying Wu
Interleukin-32 (IL-32) is an inflammatory cytokine produced mainly by T, natural killer, and epithelial cells. Previous studies on IL-32 have primarily investigated its proinflammatory properties. The IL-32 also has been described as an activator of the p38 mitogen-activated protein kinase (MAPK) and NF-κB, and induces several cytokines. In this study, we hypothesized that the inflammatory regulators NF-κB, MAP kinase, STAT1, and STAT3 are associated with the expression of the IL-32 protein in human calcified aortic valve cells...
March 1, 2018: European Cytokine Network
https://www.readbyqxmd.com/read/29748059/experience-with-the-axillary-artery-as-an-arterial-cannulation-site-in-patients-with-acute-type-a-aortic-dissection
#16
Arpit Talwar, Elvina Wiadji, Manu N Mathur
BACKGROUND: The optimal arterial cannulation site in patients undergoing surgical management of acute type A aortic dissection (ATAAD) remains controversial. The axillary artery is rarely involved in the dissection process, provides antegrade flow in the descending aorta and minimises intraoperative malperfusion. The purpose of this study is to evaluate a single surgeon's experience of axillary artery cannulation for ATAAD repair. METHODS: All consecutive patients over a 15-year period having surgical repair of ATAAD were included in this study...
March 29, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29747965/mitral-annuloplasty-ring-flexibility-preferentially-reduces-posterior-suture-forces
#17
Eric L Pierce, Charles H Bloodworth, Akito Imai, Keitaro Okamoto, Yoshiaki Saito, Robert C Gorman, Joseph H Gorman, Ajit P Yoganathan
Annuloplasty ring repair is a common procedure for the correction of mitral valve regurgitation. Commercially available rings vary in dimensions and material properties. Annuloplasty ring suture dehiscence from the native annulus is a catastrophic yet poorly understood phenomenon that has been reported across ring types. Recognizing that sutures typically dehisce from the structurally weaker posterior annulus, our group is conducting a multi-part study in search of ring design parameters that influence forces acting on posterior annular sutures in the beating heart...
May 3, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29746313/avalonelite-double-lumen-cannula-for-total-cavopulmonary-assist-in-failing-fontan-sheep-model-with-valved-extracardiac-conduit
#18
Cheng Zhou, Dongfang Wang, Francesca Condemi, Guangfeng Zhao, Stephen Topaz, Cherry Ballard-Croft, Joseph B Zwischenberger
The AvalonElite double lumen cannula (DLC) provides total cavopulmonary assist (CPA) in failing Fontan sheep, but recirculation limits reliability. To improve CPA performance, a two-valve extracardiac conduit (ECC) was used to bracket infusion blood toward pulmonary artery (PA). A total cavopulmonary connection with failing Fontan circulation adult sheep model was created with valved ECC (n = 6). The valved ECC was connected to superior/inferior venae cavae (SVC/IVC) and right PA. The AvalonElite DLC was inserted from right jugular vein with infusion opening between the ECC valves...
May 8, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29743347/computational-modeling-guides-tissue-engineered-heart-valve-design-for-long-term-in-vivo-performance-in-a-translational-sheep-model
#19
Maximilian Y Emmert, Boris A Schmitt, Sandra Loerakker, Bart Sanders, Hendrik Spriestersbach, Emanuela S Fioretta, Leon Bruder, Kerstin Brakmann, Sarah E Motta, Valentina Lintas, Petra E Dijkman, Laura Frese, Felix Berger, Frank P T Baaijens, Simon P Hoerstrup
Valvular heart disease is a major cause of morbidity and mortality worldwide. Current heart valve prostheses have considerable clinical limitations due to their artificial, nonliving nature without regenerative capacity. To overcome these limitations, heart valve tissue engineering (TE) aiming to develop living, native-like heart valves with self-repair, remodeling, and regeneration capacity has been suggested as next-generation technology. A major roadblock to clinically relevant, safe, and robust TE solutions has been the high complexity and variability inherent to bioengineering approaches that rely on cell-driven tissue remodeling...
May 9, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29740591/postnatal-and-adult-aortic-heart-valves-have-distinctive-transcriptional-profiles-associated-with-valve-tissue-growth-and-maintenance-respectively
#20
Emily Nordquist, Stephanie LaHaye, Casey Nagel, Joy Lincoln
Heart valves are organized connective tissues of high mechanical demand. They open and close over 100,000 times a day to preserve unidirectional blood flow by maintaining structure-function relationships throughout life. In affected individuals, structural failure compromises function and often leads to regurgitant blood flow and progressive heart failure. This is most common in degenerative valve disease due to age-related wear and tear, or congenital malformations. At present, the only effective treatment of valve disease is surgical repair or replacement and this is often impermanent and requires anti-coagulation therapy throughout life...
2018: Frontiers in Cardiovascular Medicine
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