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silymarin in esrd

Luminita Voroneanu, Dimitrie Siriopol, Raluca Dumea, Silvia Badarau, Mehmet Kanbay, Baris Afsar, Cristina Gavrilovici, Adrian Covic
BACKGROUND: In the last decade, despite constant investigation, no current single treatment has been able to decrease the incidence of diabetic nephropathy and to significantly reduce progression of diabetic CKD. METHODS: Patients with type 2 diabetes mellitus and proteinuria (>0.5 g/day) after a screening and treatment optimization phase were randomly assigned to receive silymarin or placebo. The primary outcome was a composite outcome: mortality, decline of eGFR > 50% and renal replacement therapy...
December 2017: International Urology and Nephrology
Luminita Voroneanu, Ionut Nistor, Raluca Dumea, Mugurel Apetrii, Adrian Covic
Type 2 diabetes mellitus (T2DM) is associated with increased risk of cardiovascular disease and nephropathy-now the leading cause of end-stage renal disease and dialysis in Europe and the United States. Inflammation and oxidative stress play a pivotal role in the development of diabetic complications. Silymarin, an herbal drug with antioxidant and anti-inflammatory properties, may improve glycemic control and prevent the progression of the complications. In a systematic review and meta-analysis including five randomized controlled trials and 270 patients, routine silymarin administration determines a significant reduction in fasting blood glucose levels (-26...
2016: Journal of Diabetes Research
Omidreza Firuzi, Soraya Khajehrezaei, Shahrokh Ezzatzadegan, Maryam Nejati, Keramat-Allah Jahanshahi, Jamshid Roozbeh
Introduction End-stage renal disease (ESRD) patients especially those undergoing dialysis are vulnerable to several complications, in particular those related to oxidative stress. Silymarin is an herbal medicine commonly used as an antioxidant in different pathologies. Methods To evaluate the effect of silymarin on biochemical and oxidative stress markers, 50 ESRD patients undergoing peritoneal dialysis were randomly divided into two groups of silymarin (n = 28) and control (n = 22) and received silymarin (140 mg every 8 hours) or placebo for 2 months, respectively...
October 2016: Hemodialysis International
Victor Gueutin, Marion Gauthier, Maud Cazenave, Hassane Izzedine
Diabetic nephropathy is a leading cause of end-stage renal disease worldwide. The mainstay of treatment has been management of hyperglycaemia, blood pressure and proteinuria using hypoglycemic agents, ACE inhibitors, and angiotensin receptor blockers. Since 2000, new therapeutic strategies began to emerge targeting the biochemical activity of glucose molecules on the renal tissue. Various substances have been studied with varying degrees of success, ranging from vitamin B to camel's milk. Silymarin reduces urinary excretion of albumin, tumor necrosis factor (TNF)-α, and malondialdehyde in patients with diabetic nephropathy and may be considered as a novel addition to the anti-diabetic nephropathy armamentarium...
July 2014: Néphrologie & Thérapeutique
Nagarajan Sheela, Manonmani Alvin Jose, Duraiswami Sathyamurthy, Balasubramanian Nandha Kumar
INTRODUCTION: Diabetic nephropathy is the major cause of end-stage renal disease worldwide. Silymarin is a flavonoid mixture obtained from Silybum marianum. Various preclinical and clinical studies have revealed that it has antidiabetic activity. The objective of this study was to evaluate the effect of silymarin on type 2 diabetic nephropathy in rats. MATERIALS AND METHODS: Non-insulin-dependent diabetes mellitus was induced in overnight-fasted male albino Wistar rats by an intramuscular injection of streptozotocin and nicotinamide...
March 2013: Iranian Journal of Kidney Diseases
Mohammad Kazem Fallahzadeh, Banafshe Dormanesh, Mohammad Mahdi Sagheb, Jamshid Roozbeh, Ghazal Vessal, Maryam Pakfetrat, Yahya Daneshbod, Eskandar Kamali-Sarvestani, Kamran B Lankarani
BACKGROUND: A large proportion of patients with type 2 diabetes mellitus have diabetic nephropathy. Despite current therapies including renin-angiotensin system inhibitors, diabetic nephropathy progresses to end-stage renal disease in most of these patients. Therefore, there is an urgent need to find new treatments for such patients. The aim of this study was to evaluate the efficacy of silymarin, an herbal drug with antioxidant and anti-inflammatory properties, in preventing the progression of diabetic nephropathy...
December 2012: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Jamshid Roozbeh, Bahram Shahriyari, Masoumeh Akmali, Ghazal Vessal, Maryam Pakfetrat, Ghanbar Ali Raees Jalali, Raha Afshariani, Mahshid Hasheminasab, Nasrollah Ghahramani
BACKGROUND: The incidence of accelerated atherosclerosis among patients on hemodialysis is very high and oxidative stress (OS) is a potentially major contributor to their morbidity and mortality. OBJECTIVE: To evaluate the effects of Silymarin and/or vitamin E on OS markers and hemoglobin levels in patients on hemodialysis. METHODS: Eighty patients on hemodialysis were randomized into four groups: Group 1 received silymarin 140 mg 3 times daily; Group 2 received vitamin E 400 IU/day; Group 3 received silymarin 140 mg 3 times daily and vitamin E 400 IU/day; and Group 4 was the control...
2011: Renal Failure
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