keyword
https://read.qxmd.com/read/38500323/effects-of-electroacupuncture-on-the-pi3k-akt-creb-signaling-pathway-and-hippocampal-neuronal-apoptosis-in-diabetic-cognitive-impairment-rats
#21
JOURNAL ARTICLE
Qian Deng, Jia-Qi Liang, Chen-Hui Gao, Xia Ge, Jin-Jin Zheng, Qing-Ping Zhang
OBJECTIVES: To observe the effects of electroacupuncture (EA) on the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/cAMP response element binding protein (CREB) signaling pathway-related proteins and hippocampal neuron apoptosis in diabetic cognitive impairment (DCI) rats, and to explore the mechanisms of EA in treating DCI. METHODS: Adult male SD rats were randomly divided into normal, model, and EA groups, with 12 rats in each group. The animal model of DCI was replicated using a high-fat, high-sugar diet combined with low-dose streptozotocin...
March 25, 2024: Zhen Ci Yan Jiu, Acupuncture Research
https://read.qxmd.com/read/38499969/cutaneous-lymphoproliferative-disorders-back-to-the-future
#22
REVIEW
Rein Willemze
In the 1980s, immunohistochemistry and clonality analyses became instrumental in the recognition and definition of new types of cutaneous T-cell lymphoma (CTCL) and cutaneous B-cell lymphoma (CBCL) and the development of new classifications. By accepting loss of pan-T-cell antigens and clonal T-cell receptor gene rearrangements as important criteria to differentiate between benign and malignant T-cell proliferations, and monotypic immunoglobulin light-chain expression and clonal immunoglobulin gene rearrangements as crucial criteria to distinguish between benign and malignant B-cell proliferations, many cases, until then diagnosed as cutaneous lymphoid hyperplasia or pseudolymphoma, were reclassified as primary cutaneous CD4+ small/medium T-cell lymphoma (PCSM-TCL) or primary cutaneous marginal zone lymphoma (PCMZL), respectively...
March 18, 2024: Journal of Cutaneous Pathology
https://read.qxmd.com/read/38497417/insulin-like-growth-factor-ii-mrna-binding-protein-3-is-a-highly-sensitive-marker-for-intravascular-large-b-cell-lymphoma-immunohistochemical-analysis-of-152-pathology-specimens-from-88-patients
#23
JOURNAL ARTICLE
Manduwa Saka, Masakazu Fujimoto, Kai Mizoguchi, Marina Tsujimura, Miho Saeki, Masahiro Hirata, Shinsuke Shibuya, Kentaro Odani, Takaki Sakurai, Yoshiaki Yuba, Koki Moriyoshi, Naoki Nakajima, Shinji Sumiyoshi, Fumihiko Kono, Kazuo Ono, Tomoyuki Shirase, Chihiro Watanabe, Akihiko Yoshizawa, Hironori Haga
Intravascular large B-cell lymphoma (IVLBCL) is a rare type of aggressive extranodal large B-cell lymphoma characterized by the selective growth of lymphoma cells within the lumina of blood vessels, particularly capillaries. IVLBCL lacks mass formation, and its diagnosis can be challenging. We analyzed the utility of insulin-like growth factor II mRNA-binding protein 3 (IMP3) immunohistochemistry for IVLBCL diagnosis in various organs. Double staining with paired box 5 (PAX5) was performed for validation. Overall, 152 pathological specimens (111 positive and 41 negative for IVLBCL) obtained from 88 patients with a diagnosis of IVLBCL were stained for IMP3 and IMP3/PAX5...
March 18, 2024: American Journal of Surgical Pathology
https://read.qxmd.com/read/38497173/survival-outcome-and-prognostic-factors-of-primary-spinal-cord-lymphoma
#24
JOURNAL ARTICLE
Ding Qianjin, Cheng Zhenguo, Wang Yang, Du Baoshun, Sun Laiguang
AIM: To identify the predictive factors associated with the survival of patients with a diagnosis of primary spinal cord lymphoma (PSCL). MATERIAL AND METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used in this study, which involved 254 patients with PSCL. Data on the patients' age, sex, race, pathology, Ann Arbor stage, adjuvant therapy, and year of diagnosis were collected. Univariate and multivariate Cox regression models were conducted to detect the predictive variables...
2024: Turkish Neurosurgery
https://read.qxmd.com/read/38496845/pathological-and-imaging-features-treatment-and-prognosis-of-primary-intraventricular-lymphoma-a-review-of-cases-from-a-single-center
#25
JOURNAL ARTICLE
Yuqiao Wang, Chengcheng Cui, Hafiz Khuram Raza, Hao Chen, Xiangbu Wang, Wei Zhang, Wenqing Meng, Keke Li, Zhifeng Mao, Xiujuan Sun, Shenyang Zhang
PURPOSE: The purpose of this retrospective study was to analyze the imaging and pathological features, treatment, and prognosis of patients with primary intraventricular lymphomas (PIL) in order to enhance physicians' understanding of the diagnosis and treatment of PIL. METHODS: A retrospective analysis was conducted on 13 cases of PIL that were hospitalized in our institution. Clinical and imaging data of the patients were collected and compared with the pathology data to summarize and analyze the qualitative diagnostic value of magnetic resonance (MR) features...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496369/burkitt-s-lymphoma-in-a-young-boy-progressing-to-systemic-lupus-erythematosus-during-follow-up-a-case-report-and-literature-review
#26
Chenxi Liu, Ci Pan, Yingying Jin, Hua Huang, Fei Ding, Xuemei Xu, Shengfang Bao, Xiqiong Han, Yanliang Jin
INTRODUCTION: Patients with systemic lupus erythematosus (SLE) are at a higher risk of developing cancer, particularly hematological malignancies such as lymphoma and leukemia. However, existing studies on this topic that assess cancer incidence following SLE diagnosis are limited. In addition, SLE can be diagnosed after cancer, although such cases in children have been rarely reported. CASE REPORT: We present the case of a 2.6-year-old boy who presented to our institute with fever and abdominal pain...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38496208/isolated-malignant-pleural-effusion-in-a-child-unusual-presentation-of-acute-leukemia
#27
Srinija Garlapati, Sampada Tambolkar, Sarita Verma, Nakul V Pathak, Manojkumar G Patil
Pleural effusion in the pediatric population is an abnormal pathology characterized by the accumulation of fluids between the parietal and visceral pleura. The etiology of this excessive fluid accumulation can be attributed to both infectious and non-infectious factors. Notably, Streptococcus pneumoniae stands out as the predominant infectious agent responsible for this condition. Non-infectious causative factors encompass hematolymphoid malignancies, congestive heart failure, hemothorax, hypoalbuminemia, and iatrogenic causes...
February 2024: Curēus
https://read.qxmd.com/read/38494775/-h-pylori-negative-malt-associated-extranodal-marginal-zone-lymphoma-a-comprehensive-case-report-and-literature-review
#28
JOURNAL ARTICLE
Ammar Qureshi, Akash Patel, Adewale B Ajumobi
Extranodal marginal zone B-cell lymphoma (ENMZL) of mucosa-associated lymphoid tissue (MALT), a rare subtype of B-cell lymphoma, is typically associated with Helicobacter pylori ( H pylori ) infection, especially in gastric cases. However, this article presents 2 unique cases of H pylori -negative colonic ENMZL, challenging the conventional understanding of the disease. The first case involves an 80-year-old male diagnosed with Stage 1E ENMZL in the descending colon, and the second describes a 74-year-old male with sigmoid colon ENMZL...
2024: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/38491860/sinonasal-tumors-masquerading-as-invasive-fungal-sinusitis-ifs
#29
JOURNAL ARTICLE
Kaitlynne Y Pak, Victor B Hsue, Matthew K Lee, Michelle M Chen, Bonnie Balzer, Arthur W Wu, Dennis M Tang
OBJECTIVES: Fungal tissue invasion in the setting of sinonasal malignancy has been rarely described in the literature. Only a handful of studies have discussed cases of suspected chronic and acute IFS (CIFS and AIFS, respectively), having an underlying undifferentiated sinonasal carcinoma, sinonasal teratocarcinosarcoma, and NK/T-cell lymphoma. METHODS: Here, we describe 3 cases of carcinoma mimicking IFS from a single institution. RESULTS: Each of our patients presented with sinonasal complaints as an outpatient in the setting of immunosuppression...
March 16, 2024: Annals of Otology, Rhinology, and Laryngology
https://read.qxmd.com/read/38485843/gastric-inflammatory-myofibroblastic-tumor-a-case-report
#30
JOURNAL ARTICLE
Taku Hattori, Yutaka Tanizawa, Tadakazu Shimoda, Yusuke Koseki, Kenichiro Furukawa, Keiichi Fujiya, Daisuke Aizawa, Takashi Sugino, Masanori Terashima, Etsuro Bando
BACKGROUND: Inflammatory myofibroblastic tumor (IMT) of the stomach is an uncommon mesenchymal neoplasm. We present a case of gastric submucosal tumor (SMT) where the final diagnosis was IMT. CASE PRESENTATION: A 69-year-old man presented with a 24-mm SMT on the posterior wall of the middle third of the stomach that was detected by screening upper gastrointestinal endoscopy. Abdominal contrast-enhanced computed tomography showed that the tumor was well-enhanced...
March 15, 2024: Surgical Case Reports
https://read.qxmd.com/read/38484479/from-the-archives-of-md-anderson-cancer-center-monomorphic-epitheliotropic-intestinal-t-cell-lymphoma-a-case-with-an-unusual-immunophenotype-and-discussion-of-differential-diagnosis
#31
REVIEW
Nicholas J Dcunha, Qing Wei, Beenu Thakral, L Jeffrey Medeiros
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare and aggressive T-cell neoplasm associated with poor survival. We report a case of MEITL that presented as an ulcerated mass in the jejunum with perforation. Microscopic examination showed that the neoplasm involved the full thickness of the intestinal wall, extended into the mesentery, and was composed of monomorphic, small to medium-size cells. Immunohistochemical analysis showed that the neoplastic cells were positive for T-cell receptor (TCR) delta, CD3, CD7, CD8 (small subset), BCL-2 and TIA-1, and negative for TCR beta, CD4, CD5, CD10, CD20, CD30, CD34, CD56, CD57, CD99, ALK, cyclin D1, granzyme B, MUM1/IRF4, and TdT...
March 8, 2024: Annals of Diagnostic Pathology
https://read.qxmd.com/read/38483832/ct-and-mr-enterography-in-the-evaluation-of-celiac-disease
#32
JOURNAL ARTICLE
Andrea Penizzotto, Florencia Vespa, Roy López Grove, Omar Rendón, Richard Tsai, Jorge Alberto Ocantos
Celiac disease is a common inflammatory disease of the small bowel that induces mucosal intestinal lesions. The disease is mediated by an immune response and triggered by the ingestion of gluten in genetically predisposed individuals. Gluten contains gliadin, a component found mostly in wheat, barley, and rye. This process leads to gastrointestinal malabsorption with symptoms such as diarrhea, constipation, abdominal pain, and distention. It has a prevalence of 1%-2% in the general adult population, who present with symptoms at any age, but is more frequently found in adult women in the 3rd or 4th decade of life...
April 2024: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://read.qxmd.com/read/38483129/gastric-metastasis-from-breast-cancer-five-cases-and-a-single-institutional-review
#33
JOURNAL ARTICLE
Meng Cheng, Zhanli Jia, Guoyu Zhang, Yingnan Wang, Sainan Li, Shan Yang, Chunxiao Li, Cuizhi Geng
Gastric metastasis from breast cancer has a high rate of misdiagnosis and missed diagnosis. Data of patients who had gastric metastasis from breast cancer were retrieved from our hospital between 2014 and 2020. The gastric metastasis from breast cancer incidence was 0.04% (5/14,169 cases of breast cancer). Four patients had invasive lobular carcinoma, and the other patient had invasive ductal carcinoma. The time from the initial diagnosis of breast cancer to the appearance of gastric metastasis ranged from 0 to 12 years...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38482079/primary-diffuse-large-b-cell-lymphoma-of-the-colon-presenting-as-idiopathic-thrombocytopenia-a-case-report
#34
Jayasree Ravilla, Farah Heis, Siva N Srinivas Yarrarapu, Jian Li, Sobaan Taj, Harshavardhan Sanekommu, Muhammed Tayyeb, Du Doantrang, Andrew Kruger
INTRODUCTION: Primary lymphoma of the colon and rectum is an uncommon form of cancer comprising less than 0.5% of all colorectal tumors combined. Typically, extra nodal lymphomas manifest in the gastrointestinal tract, with non - Hodgkin lymphoma being the most frequent subtype and the stomach being the most common location. CASE PRESENTATION: 70 year old female with medical history of osteoarthritis and osteoporosis was evaluated for bilateral leg rash and thrombocytopenia...
2024: Journal of Community Hospital Internal Medicine Perspectives
https://read.qxmd.com/read/38481953/case-report-a-case-of-third-degree-atrioventricular-block-associated-with-primary-cardiac-lymphoma
#35
Jianping Liu, Yong Zheng, Weishan Zhang, Juan Xia, Yongheng Zhang, Long Tang
BACKGROUND: Primary cardiac lymphoma is an extremely rare malignant lymphoma, with clinical manifestations related to its location. We reported the diagnosis and treatment of primary cardiac lymphoma in a patient presented with atrioventricular block. CASE PRESENTATION: A 64 year-old man was admitted to our hospital because of symptoms of a tired heart and shortness of breath. The initial electrocardiogram revealed a third-degree atrioventricular block. Computed tomography scan showed an irregularly shaped right heart, irregular clusters, and relatively weakly enhanced areas in the right auricle, atrium, and ventricle...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38476427/stereotactic-biopsy-for-brain-lesions-doing-more-with-less
#36
JOURNAL ARTICLE
Mayank Singh, T P Waseem Ahamed, Ved Prakash Maurya, Pragya Gupta, Kamlesh Singh Bhaisora, Arun Kumar Srivastava, Pawan Kumar Verma, Kuntal Kanti Das, Ashutosh Kumar, Priyadarshi Dikshit, Anant Mehrotra, Awadhesh Kumar Jaiswal, Sanjay Behari, Raj Kumar
OBJECTIVES: Stereotactic biopsy (STB) is a potential diagnostic tool considering its minimal invasiveness, high diagnostic yield, and minimal associated complications. Over the years, various frame-based instrument systems and frameless stereotactic biopsy systems have emerged to be employed in clinical use. With this study, we intend to get more by doing less in the form of STB for the patients of doubtful intracranial lesions treated over the past 5 years. We also want to highlight the technique of performing the procedure under scalp block, which can be used as a versatile tool in many clinical scenarios...
2024: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/38473391/a-descriptive-study-of-103-primary-cutaneous-b-cell-lymphomas-clinical-and-pathological-characteristics-and-treatment-from-the-spanish-lymphoma-oncology-group-gotel
#37
JOURNAL ARTICLE
Natividad Martínez-Banaclocha, Francisca Martínez-Madueño, Berta Caballé, Joan Badia, Mar Blanes, David Aguiar Bujanda, Virginia Calvo, Jose Gómez Codina, Cristina Quero Blanco, Pablo Espinosa, Javier Lavernia, Francisco Ramón García Arroyo, María Guirado Risueño, Cristina Llorca, Raquel Cumeras, Mariano Provencio Pulla, Josep Gumà
Primary cutaneous B-cell lymphomas (PCBCLs) are B-cell lymphomas that can occur in the skin without evidence of extracutaneous involvement. The 2005 WHO/EORTC classification of cutaneous lymphomas and its 2018 update have distinguished three main categories based on clinicopathological, immunohistochemical, and genetic characteristics: primary cutaneous marginal zone lymphoma (PCMZL), primary cutaneous follicle centre lymphoma (PCFCL), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT)...
March 3, 2024: Cancers
https://read.qxmd.com/read/38473116/ectopic-pregnancy-and-t-cell-lymphoma-in-a-eurasian-red-squirrel-sciurus-vulgaris-possible-comorbidity-and-a-comparative-pathology-perspective
#38
Caterina Raso, Valentina Galietta, Claudia Eleni, Marco Innocenti, Niccolò Fonti, Tiziana Palmerini, Mauro Grillo, Pietro Calderini, Elena Borgogni
Ectopic pregnancy (EP) is a life-threatening disease that affects humans and other mammals. Tumors causing ruptures of the reproductive tract have been identified as possible predisposing factors in human and veterinary medicine. We here describe a case of concomitant ectopic pregnancy and lymphoma in a Eurasian red squirrel found deceased in Italy and submitted to the public health laboratory Istituto Zooprofilattico Sperimentale del Lazio e della Toscana (IZSLT) for post-mortem examination. A full-term partially mummified ectopic fetus in the abdomen and a large fibrinonecrotic tubal scar adjacent to the right ovary were observed at necropsy...
February 27, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38473024/clinicopathologic-and-endosonographic-characteristics-of-colon-subepithelial-tumors-discovered-incidentally
#39
JOURNAL ARTICLE
Aryoung Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim, Ji Eun Kim, Eun Ran Kim
BACKGROUND/AIMS: Colonoscopy is commonly used for colorectal cancer screening; therefore, the detection of colon subepithelial tumors (SETs) has also increased. Several research studies have been undertaken to diagnose and treat stomach and rectal SETs. The purpose of this study was to determine a diagnostic point for colon SETs by comparing histological findings with the endoscopic characteristics of colon SETs discovered by chance. METHODS: A total 194 patients underwent an endoscopic ultrasound (EUS) for suspicious colon SETs during a colonoscopy from May 2014 to December 2021...
March 5, 2024: Diagnostics
https://read.qxmd.com/read/38471291/peripheral-t-cell-lymphoma-initially-presenting-in-lung-biopsies-a-diagnostic-challenge
#40
JOURNAL ARTICLE
Lu He, Xianzheng Gao, Fanqing Meng, Jieyu Chen, Qianyun Shi, Linyue Zhao, Jun Yang, Qiang Zhou, Hongyan Wu, Wencai Li, Zhiwen Li
BACKGROUND: Primary or secondary pulmonary involvement by peripheral T cell lymphoma (PTCL) is rare and difficult to diagnose particularly via lung biopsies. METHODS: 22 cases of PTCL diagnosed initially in lung biopsies between January 2006 and November 2020 were retrospectively reviewed followed at Nanjing Drum Tower Hospital and the First Affiliated Hospital of Zhengzhou University, respectively, including clinical manifestations, baseline biochemical indexes, images, histological findings and other available ancillary studies such as immunostaining, Epstein-Barr virus encoded RNA (EBER) in situ hybridization and T-cell receptor rearrangement analysis upon diagnosis...
March 2, 2024: Pathology, Research and Practice
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