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Lymphoma pathology

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https://www.readbyqxmd.com/read/28806244/lymphoma-causing-gastrosplenic-fistula-revealed-by-fdg-pet-ct
#1
Trent P Wang, Mohan Doss, Jeffrey L Tokar, Sanjay Reddy, Stefan K Barta, Jian Q Yu
A 73-year-old man presented with fatigue and weight loss. He had CT-proven splenic mass with fistulous connection to the greater curvature of the stomach, which suggested abscess. FDG PET/CT confirmed gastrosplenic fistula in addition to active lymph nodes in the gastrohepatic ligament and epigastric region. Pathological examination after the biopsy of the spleen was consistent with diffuse large B-cell lymphoma. Chemotherapy was administered with close clinical follow-up and resulted in the resolution of fistula without requirement for surgery...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28806241/fdg-pet-ct-in-primary-splenic-angiosarcoma-with-diffuse-involvement-of-the-spleen
#2
Qian Zhao, Aisheng Dong, Yang Wang, Tianlin He, Changjing Zuo
Primary splenic angiosarcoma is rare. A 44-year-old man presented with abdominal distension and malaise for 7 months. Laboratory tests showed anemia. Abdominal ultrasound showed enlargement of the spleen with multiple hypoechoic nodules. These nodules showed progressive enhancement on dynamic enhanced CT. Lymphoma was suspected. FDG PET/CT showed increased nonuniform FDG uptake with SUVmax of 11.6 of the entire spleen. Laparoscopic splenectomy was performed. The pathologic findings were consisted with angiosarcoma with replacement of the spleen...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28802499/cutaneous-t-cell-lymphoma
#3
REVIEW
Melissa Pulitzer
Cutaneous T-cell lymphomas comprise a heterogeneous group of diseases characterized by monoclonal proliferations of T lymphocytes primarily involving skin, modified skin appendages, and some mucosal sites. This article addresses the basic clinical, histologic, and immunohistochemical characteristics of this group of diseases, with additional attention to evolving literature on dermoscopy, reflectance confocal microscopy, flow cytometry, and molecular data that may increasingly be applied to diagnostic and therapeutic algorithms in these diseases...
September 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28794637/the-role-of-mediastinoscopy-in-the-diagnosis-of-non-lung-cancer-diseases
#4
Serdar Onat, Gungor Ates, Alper Avcı, Tekin Yıldız, Ali Birak, Cihan Akgul Ozmen, Refik Ulku
BACKGROUND: Mediastinoscopy is a good method to evaluate mediastinal lesions. We sought to determine the current role of mediastinoscopy in the investigation of non-lung cancer patients with mediastinal lymphadenopathy. MATERIALS AND METHODS: We retrospectively reviewed clinical parameters (age, gender, histological diagnosis, morbidity, mortality) of all patients without lung cancer who consecutively underwent mediastinoscopy in Hospital of Faculty of Medicine of Dicle University between June 2003 and December 2016...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28794358/the-clinical-and-hormonal-characteristics-of-primary-adrenal-lymphomas-the-necessity-of-early-detection-of-adrenal-insufficiency
#5
Ko Harada, Kosuke Kimura, Masaya Iwamuro, Tomohiro Terasaka, Yoshihisa Hanayama, Eisei Kondo, Eiko Hayashi, Tadashi Yoshino, Fumio Otsuka
Objective To analyze the clinical and endocrine characteristics of patients with primary adrenal lymphoma. Patients We retrospectively reviewed the cases of five patients with primary adrenal lymphoma who were treated in our hospital between April 2004 and March 2015. We investigated the characteristics of the clinical and pathological findings, treatment, prognosis and complications of adrenal insufficiency. Results Adrenal insufficiency, which was confirmed by the laboratory data at the initial presentation, was observed in two cases...
August 10, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28783523/a-case-of-sclerosing-angiomatoid-nodular-transformation-of-the-spleen-with-increased-accumulation-of-fluorodeoxyglucose-after-5-year-follow-up
#6
Keiso Matsubara, Akihiko Oshita, Takashi Nishisaka, Tamito Sasaki, Yasuhiro Matsugu, Hideki Nakahara, Takashi Urushihara, Toshiyuki Itamoto
INTRODUCTION: Sclerosing angiomatoid nodular transformation (SANT) of spleen is a new entity defined as a benign pathologic lesion. Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) shows weak accumulation, thereby ruling out the malignancy in preoperative diagnosis is difficult. Herein, we reported a case of shrinking SANT with increased FDG accumulation during a 5-year follow-up period, which was treated by laparoscopic splenectomy. PRESENTATION OF CASE: A 64-year-old female had been referred to our hospital for the evaluation of a splenic tumor...
July 21, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28777267/mistaken-identity-asthma-and-croup-in-a-previously-healthy-9-year-old-male
#7
Sylvia Owusu-Ansah, Oluwakemi Badaki-Makun, Thuy L Ngo
Cough is one of the most common presenting complaints encountered in primary care settings and the emergency department. In 2010, the Centers for Disease Control and Prevention reported approximately 31 million visits to ambulatory care centers for cough, making cough the most frequent presenting complaint in ambulatory visits (2010 National Ambulatory Medical Care Survey). Significant causes of cough can often be overlooked because it is a common symptom of a myriad of pathologies. We report the case of an otherwise healthy 9-year-old male who presented with worsening cough over a month and a half, subsequently noted to have a mediastinal mass, and diagnosed with lymphoma...
August 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28776574/increased-myc-copy-number-is-an-independent-prognostic-factor-in-patients-with-diffuse-large-b-cell-lymphoma
#8
Andrés E Quesada, L Jeffrey Medeiros, Parth A Desai, Pei Lin, Jason R Westin, Huda M Hawsawi, Peng Wei, Guilin Tang, Adam C Seegmiller, Nishitha M Reddy, C Cameron Yin, Wei Wang, Jie Xu, Roberto N Miranda, Zhuang Zuo, Shaoying Li
Patients with double-hit or triple-hit lymphoma have a significantly worse prognosis compared to patients with diffuse large B-cell lymphoma without MYC rearrangement. However, the prognostic importance of extra copies of MYC, BCL2, or BCL6 has not been fully explored. We studied 663 patients with de novo diffuse large B-cell lymphoma in whom the status of MYC/8q24, BCL2/18q21, and BCL6/3q27 were assessed by fluorescence in situ hybridization. Cases of double or triple extra copy lymphoma were defined by the presence of increased MYC copies and increased BCL2 and/or BCL6 copies or rearrangement...
August 4, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28775174/comparison-of-protein-based-cell-of-origin-classification-to-the-lymph2cx-rna-assay-in-a-cohort-of-diffuse-large-b-cell-lymphomas-in-malaysia
#9
Kean-Chang Phang, Ariz Akhter, Nur Maya Sabrina Tizen, Faridah Abd Rahman, Raja Zahratul Azma, Ghaleb Elyamany, Meer-Taher Shabani-Rad, Noraidah Masir, Adnan Mansoor
AIMS: The cell of origin (COO) based molecular characterisation into germinal centre B-cell-like (GCB) and activated B-cell-like (ABC) subtypes are central to the pathogenesis and clinical course in diffuse large B-cell lymphoma (DLBCL). Globally, clinical laboratories employ pragmatic but less than ideal immunohistochemical (IHC) assay for COO classification. Novel RNA-based platforms using routine pathology samples are emerging as new gold standard and offer unique opportunities for assay standardisation for laboratories across the world...
August 3, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28771798/primary-parotid-lymphoma-presenting-as-a-recurrent-cystic-mass-a-case-report
#10
Steven D Rosenblatt, Nikolaus E Wolter, Bradford Siegele, Jacob R Brodsky
A 15-year-old boy was diagnosed with a cystic parotid mass, which was initially thought to be a first branchial cleft cyst. The mass was treated with antibiotics and fully resolved on examination and imaging. The mass returned, and a superficial parotidectomy was performed to remove the suspected branchial cleft cyst. Final pathology demonstrated a B-cell lymphoblastic lymphoma. Bilateral bone marrow biopsies and peripheral blood counts were negative for any malignancy. This case demonstrates a rare presentation of primary parotid B-cell lymphoblastic lymphoma that began as a fluctuating cystic parotid mass consistent in appearance with a first branchial cleft cyst...
August 3, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28770352/primary-ovarian-burkitt-s-lymphoma-a-rare-oncological-problem-in-gynaecology-a-review-of-literature
#11
REVIEW
Anna Stepniak, Piotr Czuczwar, Piotr Szkodziak, Ewa Wozniakowska, Slawomir Wozniak, Tomasz Paszkowski
PURPOSE: This review presents the information about epidemiology, clinical manifestation, diagnosis and treatment of primary ovarian Burkitt's lymphoma (BL), including a literature search of available BL cases. The purpose of this review is to draw clinicians' attention to the possibility of ovarian BL occurrence, which may be important in the differential diagnosis of ovarian tumours. METHODS: PubMed and Web of Science databases were searched using the keywords ''Burkitt's'', ''Lymphoma'', ''Ovarian'', ''Primary'', ''Burkitt's lymphoma''...
August 2, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28761209/extranodal-non-hodgkin-s-lymphoma-of-the-oral-cavity-a-case-report
#12
Babyamma Raghavan Varun, Nettiyat Oommen Varghese, Trivandrum Thanappan Sivakumar, Anna Palliath Joseph
Lymphomas are solid malignant tumors having a wide spectrum of clinical and pathological features. Non-Hodgkin's lymphoma (NHL) is a subtype of lymphoma with two-thirds of the cases presenting as lymph node enlargement. The remaining one third of NHL cases has been reported in the extranodal sites, including the gastro intestinal tract, Waldeyer's ring, bone, skin, and brain. Intraoral non-Hodgkin's lymphoma is uncommon and may affect either the jaw bones or occur within the soft tissues of the oral cavity...
July 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28756244/high-frequency-of-bob1-lo-t-follicular-helper-cells-in-florid-reactive-follicular-hyperplasia
#13
Hiroshi Matsumiya, Koji Kawata, Ryuta Kamekura, Chieko Tsubomatsu, Sumito Jitsukawa, Takamasa Asai, Syunsuke Akasaka, Motonari Kamei, Keiji Yamashita, Fumie Ito, Terufumi Kubo, Noriyuki Sato, Ken-Ichi Takano, Tetsuo Himi, Shingo Ichimiya
Florid reactive follicular hyperplasia (FRFH), which is characterized by large germinal centers (GCs) within normal lymphoid follicles, is often observed in benign lesions of lymph nodes and other tissues. Because of the histologic similarity of FRFH to tumorous lesions such as follicular lymphoma, careful pathological examination is required to evaluate such lesions; however, little is known about the mechanism underlying the development of FRFH. In this study, we investigated T follicular helper (Tfh) cells in hyperplastic tonsils of patients with obstructive sleep apnea syndrome (OSA), which frequently exhibits typical FRFH...
July 26, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28751057/the-role-of-surgical-management-in-primary-small-bowel-lymphoma-a-single-center-experience
#14
Y-W Hong, I-M Kuo, Y-Y Liu, T-S Yeh
INTRODUCTION: Information on primary small intestinal lymphoma is more limited than for gastric lymphoma because most of the previous studies did not focus on the former. Few prognostic indicators in primary intestinal lymphoma have been reliably established because of limited patient numbers and variations in criteria for patient selection. In this study, we retrospectively reviewed the clinical and pathological characteristics of small intestinal lymphoma cases from our hospital, to determine prognostic factors and to clarify the effect of surgical resection on prognosis...
July 18, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28749851/immunoglobulin-g4-igg4-positive-ocular-adnexal-mucosa-associated-lymphoid-tissue-lymphoma-and-idiopathic-orbital-inflammation
#15
Eun Jung Sohn, Hee Bae Ahn, Mee Sook Roh, Woo Jun Jung, Won Yeol Ryu, Yoon Hyung Kwon
PURPOSE: To report clinical and pathological characteristics of idiopathic orbital inflammation and ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma with immunoglobulin G4 (IgG4)-positive plasma cells. METHODS: A retrospective histopathological review and clinical case series. A total of 51 biopsy samples from January 2005 to December 2015 were used in this study, including 21 cases of biopsy-confirmed idiopathic orbital inflammation and 30 cases of biopsy-confirmed ocular adnexal MALT lymphoma...
July 26, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28745554/anaplastic-lymphoma-kinase-rearrangements-in-non-small-cell-lung-cancer-novel-applications-in-diagnostics-and-treatment
#16
Rodney E Shackelford, Junaid M Ansari, Eric X Wei, Jonathan S Alexander, James Cotelingam
The ALK gene, first identified as an anaplastic large cell lymphoma driver mutation, is dysregulated in nearly 20 different human malignancies, including 3-7% of non-small-cell lung cancers (NSCLC). In NSCLC, ALK commonly fuses with the EML4, forming a constitutively active tyrosine kinase that drives oncogenic progression. Recently, several ALK-inhibiting drugs have been developed that are more effective than standard chemotherapeutic regimens in treating advanced ALK-positive NSCLC. For this reason, molecular diagnostic testing for dysregulated ALK expression is a necessary part of identifying optimal NSCLC treatment options...
August 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28739500/breast-implant-capsule-associated-squamous-cell-carcinoma-a-report-of-two-cases
#17
Daniel L Olsen, Gary L Keeney, Beiyun Chen, Daniel W Visscher, Jodi M Carter
The use of prosthetic implants for breast augmentation has become commonplace. While implants do not increase the risk of conventional mammary carcinoma, they are rarely associated with anaplastic large cell lymphoma. We report two cases of breast implant capsule-associated squamous cell carcinoma with poor clinical outcomes. Both patients (56-year-old female and 81-year-old female) had long-standing implants (>25years) and presented with acute unilateral breast enlargement. In both cases, squamous cell carcinoma arose in (focally dysplastic) squamous epithelium-lined breast implant capsules, and widely invaded surrounding breast parenchyma or chest wall...
July 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28737285/role-of-endoscopic-ultrasound-guided-fine-needle-aspiration-biopsy-in-the-diagnosis-of-lymphoma-of-the-pancreas-a-clinicopathological-study-of-nine-cases
#18
S Sadaf, A Loya, N Akhtar, M A Yusuf
OBJECTIVE: Endoscopic ultrasound-guided-fine needle aspiration (EUS-FNA) is an established first-line procedure in the management of solid and cystic pancreatic masses. Lymphoma is an uncommon diagnosis in EUS-FNA of the pancreas, and it is more common for such a diagnosis to be because of secondary involvement of the pancreas by a lymphoproliferative disorder than for this to represent isolated primary pancreatic lymphoma (PPL). We present the clinical, EUS and cytological features of these lesions...
July 24, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28736749/synchronous-primary-renal-lymphoma-and-renal-cell-carcinoma-collision-tumors-in-the-same-kidney
#19
Neil J Kocher, Stephan Leung, Nabeel E Sarwani, Joshua I Warrick, Jay D Raman
Background: Primary renal lymphoma (PRL) is an exceptionally rare disease with under 50 reported cases in the literature. PRL is an aggressive condition that can present with nonspecific symptoms and local invasion mimicking renal cell carcinoma (RCC). We present an unusual case involving a collision tumor between PRL and RCC. Case Presentation: The patient is a 62-year-old immunosuppressed man with an incidental left renal mass on cross-sectional imaging. Renal mass biopsy confirmed clear cell type RCC. He underwent robot-assisted, laparoscopic left radical nephrectomy for presumed RCC without evidence for extrarenal disease or discernable lymphadenopathy...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/28725540/the-pathology-and-molecular-genetics-of-sarcomatoid-renal-cell-carcinoma-a-mini-review
#20
REVIEW
Shuanzeng Wei, Tahseen Al-Saleem
Sarcomatoid renal cell carcinoma is a highly aggressive tumor. It is not a distinct histologic entity as it can be found in any subtypes of renal cell carcinoma. Recent molecular and genetic evidence suggest that sarcomatoid component is transformed from a common progenitor of the associated renal cell carcinoma, and the TP53 gene plays a pivotal role in this process. The presence of sarcomatoid carcinoma indicates poor prognosis, which also correlates with the amount of the sarcomatoid component. Therefore, the presence and quantity of sarcomatoid component should be reflected in pathology reports...
2017: Journal of Kidney Cancer and VHL
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