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https://www.readbyqxmd.com/read/28420212/nutritional-status-predicts-10-year-mortality-in-patients-with-end-stage-renal-disease-on-hemodialysis
#1
Shin Sook Kang, Jai Won Chang, Yongsoon Park
Protein-energy wasting (PEW) is associated with mortality in patients with end-stage renal disease (ESRD) on maintenance hemodialysis. The correct diagnosis of PEW is extremely important in order to predict clinical outcomes. However, it is unclear which parameters should be used to diagnose PEW. Therefore, this retrospective observational study investigated the relationship between mortality and nutritional parameters in ESRD patients on maintenance hemodialysis. A total of 144 patients were enrolled. Nutritional parameters, including body mass index, serum albumin, dietary intake, normalized protein catabolic rate (nPCR), and malnutrition inflammation score (MIS), were measured at baseline...
April 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28340044/oral-ghrelin-receptor-agonist-mk-0677-increases-serum-insulin-like-growth-factor-1-in-hemodialysis-patients-a-randomized-blinded-study
#2
Garland A Campbell, James T Patrie, Bruce D Gaylinn, Michael O Thorner, Warren K Bolton
Background: . Protein-energy wasting (PEW) in end-stage renal disease (ESRD) patients is associated with increased morbidity and mortality, but options for treatment are limited. Growth hormone (GH) increases insulin-like growth factor 1 (IGF-1), with improved nutritional parameters, but must be given subcutaneously and does not provide normal GH secretion patterns. MK-0677, an oral ghrelin receptor agonist (GRA), maintains normal GH secretion and increases lean body mass in normal subjects; it has not been studied in dialysis patients, an essential step in assessing efficacy and safety prior to clinical trials...
March 3, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28299612/dietary-self-management-in-heart-failure-high-tech-or-high-touch
#3
REVIEW
Eloisa Colin-Ramirez, JoAnne Arcand, Justin A Ezekowitz
Dietary management of heart failure (HF) has largely been focused on sodium and fluid restrictions. Although safety and efficacy of these interventions in HF remain unclear, a daily sodium intake between 2000 and 3000 mg/day appears to be safe in these patients. Ongoing clinical research will inform on the safety and efficacy of a more restrictive sodium intake to less than 1500 mg/day. Data shows that routine fluid restriction in HF regardless of symptoms may be unnecessary; however, in patients with signs of congestion, fluid restriction to 2...
March 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28264439/protein-nutrition-and-malnutrition-in-ckd-and-esrd
#4
REVIEW
Yan Zha, Qi Qian
Elevated protein catabolism and protein malnutrition are common in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). The underlying etiology includes, but is not limited to, metabolic acidosis intestinal dysbiosis; systemic inflammation with activation of complements, endothelin-1 and renin-angiotensin-aldosterone (RAAS) axis; anabolic hormone resistance; energy expenditure elevation; and uremic toxin accumulation. All of these derangements can further worsen kidney function, leading to poor patient outcomes...
February 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28264031/lower-serum-potassium-associated-with-increased-mortality-in-dialysis-patients-a-nationwide-prospective-observational-cohort-study-in-korea
#5
Sunhwa Lee, Eunjeong Kang, Kyung Don Yoo, Yunhee Choi, Dong Ki Kim, Kwon Wook Joo, Seung Hee Yang, Yong-Lim Kim, Shin-Wook Kang, Chul Woo Yang, Nam Ho Kim, Yon Su Kim, Hajeong Lee
BACKGROUND: Abnormal serum potassium concentration has been suggested as a risk factor for mortality in patients undergoing dialysis patients. We investigated the impact of serum potassium levels on survival according to dialysis modality. METHODS: A nationwide, prospective, observational cohort study for end stage renal disease patients has been ongoing in Korea since August 2008. Our analysis included patients whose records contained data regarding serum potassium levels...
2017: PloS One
https://www.readbyqxmd.com/read/28249290/the-association-between-depression-perceived-health-status-and-quality-of-life-among-individuals-with-chronic-kidney-disease-an-analysis-of-the-national-health-and-nutrition-examination-survey-2011-2012
#6
Hoang Anh Nguyen, Cheryl A M Anderson, Cynthia M Miracle, Dena E Rifkin
BACKGROUND: Depression is the most common mental health disorder among those with end-stage renal disease (ESRD), with prevalence of 15-40%. However, the association between chronic kidney disease (CKD) and depression is more variable. We examined the associations of CKD with depression, perceived health status, and quality of life in the National Health and Nutrition Examination Survey (NHANES) 2011-2012. METHODS: This study included 4,075 adults. Depression was defined as a condition when a Patient Health Questionnaire score was ≥10, or when there was reported antidepressant use...
March 2, 2017: Nephron
https://www.readbyqxmd.com/read/28128635/dietary-interventions-to-contrast-the-onset-and-progression-of-diabetic-nephropathy-a-critical-survey-of-new-data
#7
Stefano Menini, Carla Iacobini, Giuseppe Pugliese, Carlo Pesce
This article is a critical overview of recent contributions on the dietary corrections and the foods that have been claimed to delay or hinder the onset of diabetic nephropathy (DN) and its progression to end-stage renal disease. Innovative dietary and behavioral approaches to the prevention and therapy of DN appear the more captivating in consideration of the rather well established protocols for glucose and blood pressure control in use. In addition to restricted caloric intake to contrast obesity and the metabolic syndrome, adjustments in the patient's macronutrients intake, and in particular some degree of reduction in protein, have been long considered in the prevention of DN progression...
January 27, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28126237/kidney-disease-and-the-westernization-and-industrialization-of-food
#8
REVIEW
Holly Kramer
The industrialization of food in the United States has led to lower prices, and families now spend a smaller percentage of their total income on food compared with past generations. The decline in prices for food commodities has led to sharp increases in food consumption, with average caloric intake in the United States now more than 500 calories higher per day compared to the 1970s. This increase in total food consumption has fueled the ongoing obesity epidemic, which in turn has likely played a role in the epidemic of end-stage renal disease during the last 2 decades...
January 23, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28088773/epidemiology-and-outcome-of-acute-pancreatitis-in-end-stage-renal-disease-dialysis-patients-a-10-year-national-cohort-study
#9
Hung-Jui Chen, Jhi-Joung Wang, Wen-Ing Tsay, Shwu-Huey Her, Cheng-Heng Lin, Chih-Chiang Chien
BACKGROUND: The objective of this study is to determine the incidence and severity of acute pancreatitis (AP) in patients with end-stage renal disease (ESRD) on dialysis and whether the dialysis modality [hemodialysis (HD) versus peritoneal dialysis (PD)] confers a higher risk for AP as well as complications or mortality related to AP. METHODS: We analyzed national health insurance claims data of 67 078 ESRD patients initiating dialysis between 1999 and 2007 in Taiwan...
January 14, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28078814/life-threatening-nutritional-deficiencies-in-a-dialysis-patient
#10
Fahad Aziz, Kunal Chaudhary
Nutritional deficiencies are very common among the patient on chronic hemodialysis. But they can be easily overlooked or misdiagnosed. Deficiencies of trace elements and phosphorous is rare among this patient population but if neglected can lead to catastrophic effects. We describe a case report of a patient with ESRD recently started on outpatient maintenance hemodialysis, who presented with life threatening muscular weakness with respiratory failure requiring prolonged mechanical ventilation. On initial workup, it was unclear what the cause of her weakness was, however, further investigations showed undetectable phosphorous levels as well as very low levels of trace elements...
January 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28064444/phosphate-binders-and-targets-over-decades-do-we-have-it-right-now
#11
Morgan Marcuccilli, Michel Chonchol, Anna Jovanovich
In advanced renal disease, the kidney is unable to maintain phosphate balance due to decreased urinary excretion as well as the imbalance of the bone metabolic axis. It is well established that hyperphosphatemia is associated with increased cardiovascular events and mortality in patients with chronic kidney disease (CKD). However, there are no randomized controlled trials that demonstrate a clear benefit on hard outcomes in lowering serum phosphate levels to recommended targets in the CKD or dialysis population...
January 8, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28060690/-peritoneal-dialysis-in-the-first-two-years-of-life-experience-of-a-nephrology-and-renal-transplantation-pediatric-unit
#12
Sofia Deuchande, Tânia Mano, Cristina Novais, Rute Machado, Rosário Stone, Margarida Almeida
INTRODUCTION: Peritoneal dialysis is the dialytic method of choice in chronic end-stage renal disease in children. This study main purpose was to characterize the long-term survival of a pediatric population who began peritoneal dialysis within the first two years of life. MATERIAL AND METHODS: A descriptive and retrospective study was performed in a portuguese nephrology and renal transplantation pediatric unit, between January 1991 and August 2014. End-stage renal disease etiology, mortality, comorbidities and complications of peritoneal dialysis and end-stage renal disease, growth and psychomotor development were evaluated...
September 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27992532/what-s-the-optimal-lipids-level-for-dialysis-patients-a-cohort-study-from-a-chinese-dialysis-center-in-a-university-hospital
#13
Wen-Ling Yang, Xue-Yan Zhu, Ning Zhu, Chun-Yan Su, Qing-Feng Han, Tao Wang, Ai-Hua Zhang
BACKGROUND: With lipid level being a major contributing factor for cardiovascular health, the high cardiovascular mortality among dialysis patients has raised substantial concerns in regard to the optimal lipid level in these patient population. OBJECTIVE: To explore the optimal lipid level for the survival of dialysis patients. METHODS: The lipid profile was measured for each patient. All participants were followed throughout the course of the study...
2016: PloS One
https://www.readbyqxmd.com/read/27957414/current-characteristics-of-dialysis-therapy-in-korea-2015-registry-data-focusing-on-elderly-patients
#14
REVIEW
Dong-Chan Jin, Sung-Ro Yun, Seoung Woo Lee, Sang-Woong Han, Won Kim, Jongha Park
Because of increases in the elderly population and diabetic patients, the proportion of elderly among dialysis patients has rapidly increased during the last decades. The mortality and morbidity of these elderly dialysis patients are obviously much higher than those of young patients, but large analytic studies about elderly dialysis patients' characteristics have rarely been published. The registry committee of the Korean Society of Nephrology has collected data about dialysis therapy in Korea through an Internet online registry program and analyzed the characteristics...
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27897415/sarcopenia-among-patients-receiving-hemodialysis-weighing-the-evidence
#15
Piyawan Kittiskulnam, Juan J Carrero, Glenn M Chertow, George A Kaysen, Cynthia Delgado, Kirsten L Johansen
BACKGROUND: There is no consensus on how best to define low muscle mass in patients with end-stage renal disease. Use of muscle mass normalized to height-squared has been suggested by geriatric societies but may underestimate sarcopenia, particularly in the setting of excess adiposity. We compared four definitions of low muscle mass in a prevalent hemodialysis cohort. METHODS: ACTIVE/ADIPOSE enrolled prevalent patients receiving hemodialysis from the San Francisco and Atlanta areas from June 2009 to August 2011...
February 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27881607/bicarbonate-balance-and-prescription-in-esrd
#16
Matthew K Abramowitz
The optimal approach to managing acid-base balance is less well defined for patients receiving hemodialysis than for those receiving peritoneal dialysis. Interventional studies in hemodialysis have been limited and inconsistent in their findings, whereas more compelling data are available from interventional studies in peritoneal dialysis. Both high and low serum bicarbonate levels associate with an increased risk of mortality in patients receiving hemodialysis, but high values are a marker for poor nutrition and comorbidity and are often highly variable from month to month...
March 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27856490/prevalence-and-contents-of-advance-directives-of-patients-with-esrd-receiving-dialysis
#17
Molly A Feely, Daniel Hildebrandt, Jithinraj Edakkanambeth Varayil, Paul S Mueller
BACKGROUND AND OBJECTIVES: ESRD requiring dialysis is associated with increased morbidity and mortality rates, including increased rates of cognitive impairment, compared with the general population. About one quarter of patients receiving dialysis choose to discontinue dialysis at the end of life. Advance directives are intended to give providers and surrogates instruction on managing medical decision making, including end of life situations. The prevalence of advance directives is low among patients receiving dialysis...
December 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27843345/the-danish-nephrology-registry
#18
REVIEW
James Heaf
AIM OF DATABASE: The Danish Nephrology Registry's (DNR) primary function is to support the Danish public health authorities' quality control program for patients with end-stage renal disease in order to improve patient care. DNR also supplies epidemiological data to several international organizations and supports epidemiological and clinical research. STUDY POPULATION: The study population included patients treated with dialysis or transplantation in Denmark from January 1, 1990 to January 1, 2016, with retrospective data since 1964...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27774887/lipoprotein-subfractions-uric-acid-and-cardiovascular-risk-in-end-stage-renal-disease-esrd-patients
#19
Anna Gluba-Brzózka, Beata Franczyk, Piotr Bartnicki, Magdalena Rysz-Górzyńska, Jacek Rysz
BACKGROUND: Chronic kidney disease (CKD) poses a worldwide public health problem. CKD is an independent risk factor for cardiovascular disease (CVD). OBJECTIVE: The aim of this study was to assess the cardiovascular risk in ESRD patients and to evaluate the relationship between serum uric acid and lipoprotein subfractions. METHODS: The study group consisted of 66 patients on dialysis and control group of 25 healthy volunteers. Concentration of HDL and LDL subfractions were analysed with Lipoprint™...
October 21, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27769183/role-of-low-protein-diet-in-management-of-different-stages-of-chronic-kidney-disease-practical-aspects
#20
REVIEW
Bharat V Shah, Zamurrud M Patel
BACKGROUND: Chronic kidney disease (CKD) is a worldwide public health problem and more so in India. With limited availability and high cost of therapy, barely 10 % of patients with incident end stage renal disease (ESRD) cases get treatment in India. Therefore, all possible efforts should be made to retard progression of CKD. This article reviews the role of low protein diet (LPD) in management of CKD subjects and suggests how to apply it in clinical practice. DISCUSSION: The role of LPD in retarding progression of CKD is well established in animal experimental studies...
October 21, 2016: BMC Nephrology
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