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https://www.readbyqxmd.com/read/28298185/general-practitioners-perceptions-of-population-based-bowel-screening-and-their-influence-on-practice-a-qualitative-study
#1
Greer Dawson, Melanie Crane, Claudine Lyons, Anna Burnham, Tara Bowman, Donna Perez, Joanne Travaglia
BACKGROUND: Although largely preventable, Australia has one of the highest rates of bowel cancer in the world. General Practitioners (GPs) have an important role to play in prevention and early detection of bowel cancer, however in Australia this is yet to be optimised and participation remains low. This study sought to understand how GPs' perceptions of bowel screening influence their attitudes to, and promotion of the faecal occult blood test (FOBT), to identify opportunities to enhance their role...
March 15, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28274338/development-and-initial-validation-of-primary-care-provider-mental-illness-management-and-team-based-care-self-efficacy-scales
#2
Danielle F Loeb, Lori A Crane, Erin Leister, Elizabeth A Bayliss, Evette Ludman, Ingrid A Binswanger, Danielle M Kline, Meredith Smith, Frank V deGruy, Donald E Nease, L Miriam Dickinson
OBJECTIVE: Develop and validate self-efficacy scales for primary care provider (PCP) mental illness management and team-based care participation. STUDY DESIGN AND SETTING: We developed three self-efficacy scales: team-based care (TBC), mental illness management (MIM), and chronic medical illness (CMI). We developed the scales using Bandura's Social Cognitive Theory as a guide. The survey instrument included items from previously validated scales on team-based care and mental illness management...
March 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28270757/effectiveness-of-a-novel-qigong-meditative-movement-practice-for-impaired-health-in-flight-attendants-exposed-to-second-hand-cigarette-smoke
#3
Peter Payne, Steven Fiering, James C Leiter, David T Zava, Mardi A Crane-Godreau
This single-arm non-randomized pilot study explores an intervention to improve the health of flight attendants (FA) exposed to second-hand cigarette smoke prior to the smoking ban on commercial airlines. This group exhibits an unusual pattern of long-term pulmonary dysfunction. We report on Phase I of a two-phase clinical trial; the second Phase will be a randomized controlled trial testing digital delivery of the intervention. Subjects were recruited in the Northeastern US; testing and intervention were administered in 4 major cities...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28248604/middle-ear-obliteration-with-blind-sac-closure-of-the-external-auditory-canal-for-spontaneous-csf-otorrhea
#4
Shawn M Stevens, Ryan Crane, Myles L Pensak, Ravi N Samy
Outcome Objectives To (1) identify unique features of patients who underwent middle ear/mastoid obliteration with blind-sac closure of the external auditory canal for spontaneous cerebrospinal fluid (CSF) otorrhea and (2) explore outcomes. Study Design Case series with chart review. Setting Tertiary care center. Subjects and Methods Adults treated for spontaneous cerebrospinal fluid otorrhea from 2007 through 2015 were reviewed and stratified into 2 groups based on the surgery performed: (1) 11 patients underwent middle ear/mastoid obliteration with blind-sac closure of the external auditory canal and (2) 26 patients underwent other procedures...
March 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28239718/solvent-control-of-intramolecular-proton-transfer-is-4-hydroxy-3-piperidin-1-ylmethyl-1-naphthaldehyde-a-proton-crane
#5
Y Manolova, H Marciniak, S Tschierlei, F Fennel, F S Kamounah, S Lochbrunner, L Antonov
The solvent dependent excited state dynamics of 4-hydroxy-3-(piperidin-1-ylmethyl)-1-naphthaldehyde (compound 2), a candidate for a molecular switch based on intramolecular proton transfer, was investigated by ultrafast spectroscopy and quantum-chemical calculations. In acetonitrile a mixture of molecules in the enol and zwitterionic proton transfer (PT) form exists in the ground state. However, the zwitterion is the energetically favored one in the electronically excited state. Optical excitation of the enol form results in intramolecular proton transfer and formation of the PT form within 1...
February 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28236716/alzheimer-s-disease-neuropathologic-change-lewy-body-disease-and-vascular-brain-injury-in-clinic-and-community-based-samples
#6
Willa D Brenowitz, C Dirk Keene, Stephen E Hawes, Rebecca A Hubbard, W T Longstreth, Randy L Woltjer, Paul K Crane, Eric B Larson, Walter A Kukull
We examined the relationships between Alzheimer's disease neuropathologic change (ADNC), Lewy body disease (LBD), and vascular brain injury (VBI) in 2 large autopsy samples. Because findings may differ between study populations, data came from U.S. Alzheimer's Disease Centers contributing to the National Alzheimer's Coordinating Center (n = 2742) and from the population-based Adult Changes in Thought study (n = 499). Regardless of study population, over 50% of participants with ADNC had co-occurring LBD or VBI; the majority of whom had a clinical AD dementia diagnosis prior to death...
January 30, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28216320/coordination-of-orofacial-motor-actions-into-exploratory-behavior-by-rat
#7
Anastasia Kurnikova, Jeffrey D Moore, Song-Mao Liao, Martin Deschênes, David Kleinfeld
The delineation of sensorimotor circuits that guide exploration begins with an understanding of the pattern of motor outputs [1]. These motor patterns provide a clue to the form of the underlying circuits [2-4] (but see [5]). We focus on the behaviors that rodents use to explore their peripersonal space through goal-directed positioning of their nose, head, and vibrissae. Rodents sniff in response to novel odors, reward expectation, and as part of social interactions [6-12]. Sniffing serves olfaction [13, 14], while whisking synchronized to sniffing serves vibrissa-based touch [6, 15, 16]...
March 6, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28212814/human-striatal-dopaminergic-and-regional-serotonergic-synaptic-degeneration-with-lewy-body-disease-and-inheritance-of-apoe-%C3%AE%C2%B54
#8
Nadia Postupna, Caitlin S Latimer, Eric B Larson, Emily Sherfield, Julie Paladin, Carol A Shively, Matthew J Jorgensen, Rachel N Andrews, Jay R Kaplan, Paul K Crane, Kathleen S Montine, Suzanne Craft, C Dirk Keene, Thomas J Montine
Cognitive impairment in older individuals is a complex trait that in population-based studies most commonly derives from an individually varying mixture of Alzheimer disease, Lewy body disease, and vascular brain injury. We investigated the molecular composition of synaptic particles from three sources: consecutive rapid autopsy brains from the adult changes in thought study, a population-based cohort; four aged nonhuman primate brains optimally processed for molecular investigation; and targeted replacement transgenic mice homozygous for APOE ε4...
February 14, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28205041/hiv-provider-documentation-and-actions-following-patient-reports-of-at-risk-behaviors-and-conditions-when-identified-by-a-web-based-point-of-care-assessment
#9
Heidi M Crane, Paul K Crane, James T Tufano, James D Ralston, Ira B Wilson, Tyler D Brown, Thomas E Davis, Laurie F Smith, William B Lober, Justin McReynolds, Shireesha Dhanireddy, Robert D Harrington, Carla V Rodriguez, Robin M Nance, Joseph A C Delaney, Steven A Safren, Mari M Kitahata, Rob J Fredericksen
We compared same-day provider medical record documentation and interventions addressing depression and risk behaviors before and after delivering point-of-care patient-reported outcomes (PROs) feedback for patients who self-reported clinically relevant levels of depression or risk behaviors. During the study period (1 January 2006-15 October 2010), 2289 PRO assessments were completed by HIV-infected patients. Comparing the 8 months before versus after feedback implementation, providers were more likely to document depression (74% before vs...
February 15, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28183528/transethnic-genome-wide-scan-identifies-novel-alzheimer-s-disease-loci
#10
Gyungah R Jun, Jaeyoon Chung, Jesse Mez, Robert Barber, Gary W Beecham, David A Bennett, Joseph D Buxbaum, Goldie S Byrd, Minerva M Carrasquillo, Paul K Crane, Carlos Cruchaga, Philip De Jager, Nilufer Ertekin-Taner, Denis Evans, M Danielle Fallin, Tatiana M Foroud, Robert P Friedland, Alison M Goate, Neill R Graff-Radford, Hugh Hendrie, Kathleen S Hall, Kara L Hamilton-Nelson, Rivka Inzelberg, M Ilyas Kamboh, John S K Kauwe, Walter A Kukull, Brian W Kunkle, Ryozo Kuwano, Eric B Larson, Mark W Logue, Jennifer J Manly, Eden R Martin, Thomas J Montine, Shubhabrata Mukherjee, Adam Naj, Eric M Reiman, Christiane Reitz, Richard Sherva, Peter H St George-Hyslop, Timothy Thornton, Steven G Younkin, Badri N Vardarajan, Li-San Wang, Jens R Wendlund, Ashley R Winslow, Jonathan Haines, Richard Mayeux, Margaret A Pericak-Vance, Gerard Schellenberg, Kathryn L Lunetta, Lindsay A Farrer
INTRODUCTION: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. METHODS: We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset...
February 7, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28182590/lens-opacity-and-hydrogen-sulfide-in-a-new-zealand-geothermal-area
#11
Michael N Bates, Ian L Bailey, Robert B DiMartino, Karl Pope, Julian Crane, Nick Garrett
PURPOSE: Hydrogen sulfide (H2S) is a highly toxic gas with well-established, acute irritation effects on the eye. The population of Rotorua, New Zealand, sited on an active geothermal field, has some of the highest ambient H2S exposures in the world. Evidence from ecological studies in Rotorua has suggested that H2S is associated with cataract. The purpose of the present study was, using more detailed exposure characterization, clinical examinations, and anterior eye photography, to more directly investigate this previously reported association...
January 11, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28171738/analysis-of-audiometric-outcomes-following-combined-middle-cranial-fossa-transmastoid-approaches-for-spontaneous-cerebrospinal-fluid-otorrhea
#12
Shawn M Stevens, Ryan Crane, Myles L Pensak, Ravi N Samy
Outcome Objectives To (1) explore audiometric outcomes following use of a combined transmastoid/middle cranial fossa (TM-MCF) approach in the treatment of spontaneous cerebrospinal fluid (CSF) otorrhea and (2) determine the influence of dehiscence location and reconstructive methodology on audiometric outcomes. Study Design Case series with chart review. Setting Tertiary care center. Subjects and Methods Adults with spontaneous CSF otorrhea were reviewed from 2007 to 2016 if they underwent combined TM-MCF. Definitive audiometric evaluations were performed at least 3 months postoperatively...
February 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28168110/nest-site-selection-reproductive-ecology-and-shifts-within-core-use-areas-of-black-necked-cranes-at-the-northern-limit-of-the-tibetan-plateau
#13
Lixun Zhang, Bei An, Meilin Shu, Xiaojun Yang
We investigated population dynamics, breeding pairs, breeding habitat selection, nest density, distance between neighboring nests, nest survival, reproductive success, and recruitment rate for Black-necked Cranes (BNC, Grus nigricollis) during 2013-2015 in Yanchiwan National Nature Reserve (YCW), Gansu, China. Numbers of BNC and breeding pairs remained relatively stable at around 140 individuals and 40 pairs. Recruitment rates ranged from 15.7% to 25.8%. The average nest distance was 718.66 ± 430.50 m (2013), 1064...
2017: PeerJ
https://www.readbyqxmd.com/read/28163876/petiolate-wings-effects-on-the-leading-edge-vortex-in-flapping-flight
#14
Nathan Phillips, Kevin Knowles, Richard J Bomphrey
The wings of many insect species including crane flies and damselflies are petiolate (on stalks), with the wing planform beginning some distance away from the wing hinge, rather than at the hinge. The aerodynamic impact of flapping petiolate wings is relatively unknown, particularly on the formation of the lift-augmenting leading-edge vortex (LEV): a key flow structure exploited by many insects, birds and bats to enhance their lift coefficient. We investigated the aerodynamic implications of petiolation P using particle image velocimetry flow field measurements on an array of rectangular wings of aspect ratio 3 and petiolation values of P = 1-3...
February 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28122876/multidimensional-prediction-of-treatment-response-to-antidepressants-with-cognitive-control-and-functional-mri
#15
Natania A Crane, Lisanne M Jenkins, Runa Bhaumik, Catherine Dion, Jennifer R Gowins, Brian J Mickey, Jon-Kar Zubieta, Scott A Langenecker
Predicting treatment response for major depressive disorder can provide a tremendous benefit for our overstretched health care system by reducing number of treatments and time to remission, thereby decreasing morbidity. The present study used neural and performance predictors during a cognitive control task to predict treatment response (% change in Hamilton Depression Rating Scale pre- to post-treatment). Forty-nine individuals diagnosed with major depressive disorder were enrolled with intent to treat in the open-label study; 36 completed treatment, had useable data, and were included in most data analyses...
February 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28109172/integrated-treatment-options-for-male-perpetrators-of-intimate-partner-violence
#16
Cory A Crane, Caroline J Easton
ISSUES: Male-to-female intimate partner violence remains a worldwide public health issue with adverse physical and psychological consequences for victims, perpetrators and children. Personality disorders, addiction, trauma and mood symptoms are established risk factors for intimate partner violence perpetration and factor prominently into a recovery-oriented treatment approach. APPROACH: We reviewed the partner violence literature for detailed reports of traditional as well as innovative, integrated treatment approaches...
January 21, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28092466/clinical-performance-of-the-solana%C3%A2-point-of-care-trichomonas-assay-from-clinician-collected-vaginal-swabs-and-urine-specimens-from-symptomatic-and-asymptomatic-women
#17
C A Gaydos, J Schwebke, J Dombrowski, J Marrazzo, J Coleman, B Silver, M Barnes, L Crane, P Fine
BACKGROUND: Solana® (Quidel) is a new rapid (<40 min.) point-of-care (POC) test for qualitative detection of Trichomonas vaginalis (TV) DNA. The assay has two steps: 1) specimen preparation, and 2) amplification and detection using isothermal Helicase-Dependent Amplification (HDA). The objective was to demonstrate the performance of Solana for vaginal swabs and female urines based on comparison to wet mount and TV culture. Performance was also compared to the Aptima-TV assay. METHODS: Urine and four clinician-collected vaginal swabs were collected...
March 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28089593/physician-knowledge-and-attitudes-about-hepatitis-a-and-current-practices-regarding-hepatitis-a-vaccination-delivery
#18
Noele P Nelson, Mandy Allison, Megan C Lindley, Michaela Brtnikova, Lori A Crane, Brenda L Beaty, Laura P Hurley, Allison Kempe
OBJECTIVES: To assess physicians' 1) knowledge and attitudes about hepatitis A disease and HepA vaccine, and 2) child care and school HepA vaccine mandates; 3) practices related to HepA vaccine delivery; 4) factors associated with strongly recommending HepA vaccine to all 1-2 year olds; and 5) feasibility of implementing HepA catch-up vaccination at health maintenance visits. METHODS: A national survey was conducted among representative networks of pediatricians and family medicine physicians (FMs) from March to June, 2014 by e-mail or mail based on provider preference...
January 9, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28089481/recommendations-for-mri-based-contouring-of-gross-tumor-volume-and-organs-at-risk-for-radiation-therapy-of-pancreatic-cancer
#19
H D Heerkens, W A Hall, X A Li, P Knechtges, E Dalah, E S Paulson, C A T van den Berg, G J Meijer, E J Koay, C H Crane, K Aitken, M van Vulpen, B A Erickson
PURPOSE: Local recurrence is a common and morbid event in patients with unresectable pancreatic adenocarcinoma. A more conformal and targeted radiation dose to the macroscopic tumor in nonmetastatic pancreatic cancer is likely to reduce acute toxicity and improve local control. Optimal soft tissue contrast is required to facilitate delineation of a target and creation of a planning target volume with margin reduction and motion management. Magnetic resonance imaging (MRI) offers considerable advantages in optimizing soft tissue delineation and is an ideal modality for imaging and delineating a gross tumor volume (GTV) within the pancreas, particularly as it relates to conformal radiation planning...
October 17, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28068240/does-unintentional-splenic-radiation-predict-outcomes-after-pancreatic-cancer-radiation-therapy
#20
Awalpreet S Chadha, Guan Liu, Hsiang-Chun Chen, Prajnan Das, Bruce D Minsky, Usama Mahmood, Marc E Delclos, Yelin Suh, Gabriel O Sawakuchi, Sam Beddar, Matthew H Katz, Jason B Fleming, Milind M Javle, Gauri R Varadhachary, Robert A Wolff, Christopher H Crane, Xuemei Wang, Howard Thames, Sunil Krishnan
PURPOSE: To determine whether severity of lymphopenia is dependent on radiation dose and fractional volume of spleen irradiated unintentionally during definitive chemoradiation (CRT) in patients with locally advanced pancreatic cancer (LAPC). METHODS: 177 patients with LAPC received induction chemotherapy (mainly gemcitabine-based regimens) followed by CRT (median 50.4 Gy with concurrent capecitabine) from January 2006 to December 2012. Absolute lymphocyte count (ALC) was recorded at baseline, before CRT, and 2 to 10 weeks after CRT...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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