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https://www.readbyqxmd.com/read/27866734/comparing-variability-severity-and-persistence-of-depressive-symptoms-as-predictors-of-future-stroke-risk
#1
Laura B Zahodne, Paola Gilsanz, M Maria Glymour, Laura E Gibbons, Paul Brewster, Jamie Hamilton, Jesse Mez, Jessica R Marden, Kwangsik Nho, Eric B Larson, Paul K Crane, Alden L Gross
OBJECTIVE: Numerous studies show that depressive symptoms measured at a single assessment predict greater future stroke risk. Longer-term symptom patterns, such as variability across repeated measures or worst symptom level, might better reflect adverse aspects of depression than a single measurement. This prospective study compared five approaches to operationalizing depressive symptoms at annual assessments as predictors of stroke incidence. DESIGN: Cohort followed for incident stroke over an average of 6...
October 24, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27807656/preliminary-characterization-of-tasmanian-aquareovirus-tsrv-isolates
#2
Sandra C Zainathan, Jeremy Carson, Mark St J Crane, Lynette M Williams, John Hoad, Nicholas J G Moody, Nicholas Gudkovs, Sandra Crameri, Alex D Hyatt, John Young, Barbara F Nowak
In an attempt to determine whether or not genetic variants of the Tasmanian strain of Atlantic salmon aquareovirus (TSRV) exist, 14 isolates of TSRV, originating from various locations in Tasmania, covering a 20-year period (1990-2010), obtained from various host species and tissues, and isolated on different cell lines, were selected for this study. Two categories, termed "typical" and "atypical", of variants of TSRV were identified based on preliminary genotypic and phenotypic characterization carried out on these 14 different isolates...
November 2, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27806937/evaluation-of-a-protocol-to-optimize-duration-of-pneumonia-therapy-at-hospital-discharge
#3
Christina Caplinger, Kendall Crane, Michelle Wilkin, Jefferson Bohan, Richard Remington, Karl Madaras-Kelly
PURPOSE: A protocol to optimize the duration of antimicrobial therapy (DAT) for uncomplicated pneumonia at hospital discharge was evaluated. METHODS: This retrospective quasiexperimental study was conducted at Boise Veterans Affairs Medical Center from March 2013 through June 2015. Patients were included in the study if they were diagnosed with pneumonia, were hospitalized for more than 24 hours, received antimicrobial treatment within 48 hours of admission, and survived until hospital discharge...
November 2, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27803157/bacterial-energy-sensor-aer-modulates-the-activity-of-the-chemotaxis-kinase-chea-based-on-the-redox-state-of-the-flavin-cofactor
#4
Dipanjan Samanta, Joanne Widom, Peter P Borbat, Jack H Freed, Brian R Crane
Flagellated bacteria modulate their swimming behavior in response to environmental cues through the CheA/CheY signaling pathway. In addition to responding to external chemicals, bacteria also monitor internal conditions that reflect the availability of oxygen, light, and reducing equivalents - in a process termed ″Energy Taxis″. In E. coli, the transmembrane receptor Aer is the primary energy sensor for motility. Genetic and physiological data suggest that Aer monitors the electron transport chain through the redox state of its FAD cofactor...
November 1, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27801957/a-new-marker-based-on-the-avian-spindlin-gene-that-is-able-to-sex-most-birds-including-species-problematic-to-sex-with-chd-markers
#5
Deborah A Dawson, Natalie Dos Remedios, Gavin J Horsburgh
We have developed a new marker (Z43B) that can be successfully used to identify the sex of most birds (69%), including species difficult or impossible to sex with other markers. We utilized the zebra finch Taeniopygia guttata EST microsatellite sequence (CK309496) which displays sequence homology to the 5' untranslated region (UTR) of the avian spindlin gene. This gene is known to be present on the Z and W chromosomes. To maximize cross-species utility, the primer set was designed from a consensus sequence created from homologs of CK309496 that were isolated from multiple distantly related species...
November 2016: Zoo Biology
https://www.readbyqxmd.com/read/27758144/genetically-engineered-macrophages-a-potential-platform-for-cancer-immunotherapy
#6
Kara W Moyes, Nicole A P Lieberman, Shannon A Kreuser, Harrison Chinn, Conrad Winter, Gail Deutsch, Virginia Hoglund, Reid Watson, Courtney A Crane
In spite of their successes against hematologic malignancies, immunotherapeutic interventions for the treatment of patients with glioblastoma (GBM) have thus far been unsuccessful. This is in part due to the presence of a tumor microenvironment that fosters neoplastic growth and protects the tumor from destruction by the immune system. A novel genetically engineered macrophage-based platform has been developed with the potential to minimize the effects of the suppressive tumor microenvironment and improve innate and adaptive antitumor immune responses...
October 18, 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27745683/understanding-and-promoting-effective-engagement-with-digital-behavior-change-interventions
#7
Lucy Yardley, Bonnie J Spring, Heleen Riper, Leanne G Morrison, David H Crane, Kristina Curtis, Gina C Merchant, Felix Naughton, Ann Blandford
This paper is one in a series developed through a process of expert consensus to provide an overview of questions of current importance in research into engagement with digital behavior change interventions, identifying guidance based on research to date and priority topics for future research. The first part of this paper critically reflects on current approaches to conceptualizing and measuring engagement. Next, issues relevant to promoting effective engagement are discussed, including how best to tailor to individual needs and combine digital and human support...
November 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27745681/the-pace-of-technologic-change-implications-for-digital-health-behavior-intervention-research
#8
Kevin Patrick, Eric B Hekler, Deborah Estrin, David C Mohr, Heleen Riper, David Crane, Job Godino, William T Riley
This paper addresses the rapid pace of change in the technologies that support digital interventions; the complexity of the health problems they aim to address; and the adaptation of scientific methods to accommodate the volume, velocity, and variety of data and interventions possible from these technologies. Information, communication, and computing technologies are now part of every societal domain and support essentially every facet of human activity. Ubiquitous computing, a vision articulated fewer than 30 years ago, has now arrived...
November 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27707688/a-randomized-controlled-trial-protocol-to-evaluate-the-effectiveness-of-an-integrated-care-management-approach-to-improve-adherence-among-hiv-infected-patients-in-routine-clinical-care-rationale-and-design
#9
Heidi M Crane, Rob J Fredericksen, Anna Church, Anna Harrington, Paul Ciechanowski, Jennifer Magnani, Kari Nasby, Tyler Brown, Shireesha Dhanireddy, Robert D Harrington, William B Lober, Jane Simoni, Stevan A Safren, Todd C Edwards, Donald L Patrick, Michael S Saag, Paul K Crane, Mari M Kitahata
BACKGROUND: Adherence to antiretroviral medications is a key determinant of clinical outcomes. Many adherence intervention trials investigated the effects of time-intensive or costly interventions that are not feasible in most clinical care settings. OBJECTIVE: We set out to evaluate a collaborative care approach as a feasible intervention applicable to patients in clinical care including those with mental illness and/or substance use issues. METHODS: We developed a randomized controlled trial (RCT) investigating an integrated, clinic-based care management approach to improve clinical outcomes that could be integrated into the clinical care setting...
October 5, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27707627/sobetirome-prodrug-esters-with-enhanced-blood-brain-barrier-permeability
#10
Andrew T Placzek, Skylar J Ferrara, Meredith D Hartley, Hannah S Sanford-Crane, J Matthew Meinig, Thomas S Scanlan
There is currently great interest in developing drugs that stimulate myelin repair for use in demyelinating diseases such as multiple sclerosis. Thyroid hormone plays a key role in stimulating myelination during development and also controls the expression of important genes involved in myelin repair in adults. Because endogenous thyroid hormone in excess lacks a generally useful therapeutic index, it is not used clinically for indications other than hormone replacement; however, selective thyromimetics such as sobetirome offer a therapeutic alternative...
September 16, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27699682/development-of-smokefree-baby-a-smoking-cessation-smartphone-app-for-pregnant-smokers
#11
Ildiko Tombor, Lion Shahab, Jamie Brown, David Crane, Susan Michie, Robert West
Pregnant smokers may benefit from digital smoking cessation interventions, but few have been designed for this population. The aim was to transparently report the development of a smartphone app designed to aid smoking cessation during pregnancy. The development of a smartphone app ('SmokeFree Baby') to help pregnant women stop smoking was guided by frameworks for developing complex interventions, including the Medical Research Council (MRC), Multiphase Optimization Strategy (MOST) and Behaviour Change Wheel (BCW)...
December 2016: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/27696955/interventions-to-reduce-intimate-partner-violence-perpetration-among-people-with-substance-use-disorders
#12
Caroline J Easton, Cory A Crane
The social and economic cost of intimate partner violence (IPV) is exorbitant and highlights the need for policy reform as it pertains to IPV interventions at a global level. There are multiple variables associated with the aetiology of IPV and, hence, multiple treatment needs must be considered. Substance use is one of several factors likely to influence the occurrence of IPV, but often goes unaddressed in standard treatment approaches. This review will discuss several treatment models for substance using offenders of IPV, including Psycho-educational Models, Cognitive Behavioural Therapy, Couples' Treatments, Parenting Programmes, Integration of Care Models, and Pharmacotherapies...
October 2016: International Review of Psychiatry
https://www.readbyqxmd.com/read/27693570/gene-duplication-and-concerted-evolution-of-mitochondrial-dna-in-crane-species
#13
Takuya Akiyama, Chizuko Nishida, Kunikazu Momose, Manabu Onuma, Kazutoshi Takami, Ryuichi Masuda
The gene duplication in mitochondrial DNA (mtDNA) has been reported in diverse bird taxa so far. Although many phylogenetic and population genetic analyses of cranes were carried out based on mtDNA diversity, whether mtDNA contains duplicated regions is unknown. To address the presence or absence of gene duplication in cranes and investigate the molecular evolutionary features of crane mtDNA, we analyzed the gene organization and the molecular phylogeny of mtDNA from 13 crane species. We found that the mtDNA in 13 crane species shared a tandem duplicated region, which consists of duplicated sequence sets including cytochrome b (Cytb), NADH6, control region (CR) and three genes of tRNA...
September 28, 2016: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/27670115/spirochaete-flagella-hook-proteins-self-catalyse-a-lysinoalanine-covalent-crosslink-for-motility
#14
Michael R Miller, Kelly A Miller, Jiang Bian, Milinda E James, Sheng Zhang, Michael J Lynch, Patrick S Callery, Justin M Hettick, Andrew Cockburn, Jun Liu, Chunhao Li, Brian R Crane, Nyles W Charon
Spirochaetes are bacteria responsible for several serious diseases, including Lyme disease (Borrelia burgdorferi), syphilis (Treponema pallidum) and leptospirosis (Leptospira interrogans), and contribute to periodontal diseases (Treponema denticola)(1). These spirochaetes employ an unusual form of flagella-based motility necessary for pathogenicity; indeed, spirochaete flagella (periplasmic flagella) reside and rotate within the periplasmic space(2-11). The universal joint or hook that links the rotary motor to the filament is composed of ∼120-130 FlgE proteins, which in spirochaetes form an unusually stable, high-molecular-weight complex(9,12-17)...
August 8, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27668804/improving-depression-among-hiv-infected-adults-transporting-the-effect-of-a-depression-treatment-intervention-to-routine-care
#15
Angela M Bengtson, Brian W Pence, Bradley N Gaynes, E Byrd Quinlivan, Amy D Heine, Julie K OʼDonnell, Heidi M Crane, W Christopher Mathews, Richard D Moore, Daniel Westreich, Conall OʼCleirigh, Katerina Christopoulos, Matthew J Mimiaga, Michael J Mugavero
BACKGROUND: Depression affects 20%-30% of people with HIV. Randomized controlled trials (RCTs) have demonstrated the effectiveness of interventions to improve depression among HIV-infected adults, but typically have highly selected populations which may limit generalizability. Inverse probability of sampling weights (IPSW) is a recently proposed method to transport (or standardize) findings from RCTs to a specific external target population. METHODS: We used IPSW to transport the 6-month effect of the Measurement-Based Care (MBC) intervention on depression from the SLAM DUNC trial to a population of HIV-infected, depressed adults in routine care in the United States between 2010 and 2014...
December 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27662217/adaptive-pid-control-based-on-orthogonal-endocrine-neural-networks
#16
Miroslav B Milovanović, Dragan S Antić, Marko T Milojković, Saša S Nikolić, Staniša Lj Perić, Miodrag D Spasić
A new intelligent hybrid structure used for online tuning of a PID controller is proposed in this paper. The structure is based on two adaptive neural networks, both with built-in Chebyshev orthogonal polynomials. First substructure network is a regular orthogonal neural network with implemented artificial endocrine factor (OENN), in the form of environmental stimuli, to its weights. It is used for approximation of control signals and for processing system deviation/disturbance signals which are introduced in the form of environmental stimuli...
September 5, 2016: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/27596590/current-and-projected-global-distribution-of-phytophthora-cinnamomi-one-of-the-world-s-worst-plant-pathogens
#17
Treena I Burgess, John K Scott, Keith L Mcdougall, Michael J C Stukely, Colin Crane, William A Dunstan, Frances Brigg, Vera Andjic, Diane White, Tim Rudman, Frans Arentz, Noboru Ota, Giles E St J Hardy
Globally, Phytophthora cinnamomi is listed as one of the 100 worst invasive alien species and active management is required to reduce impact and prevent spread in both horticulture and natural ecosystems. Conversely, there are regions thought to be suitable for the pathogen where no disease is observed. We developed a climex model for the global distribution of P. cinnamomi based on the pathogen's response to temperature and moisture and by incorporating extensive empirical evidence on the presence and absence of the pathogen...
September 6, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27513328/disparities-in-depressive-symptoms-and-antidepressant-treatment-by-gender-and-race-ethnicity-among-people-living-with-hiv-in-the-united-states
#18
Angela M Bengtson, Brian W Pence, Heidi M Crane, Katerina Christopoulos, Rob J Fredericksen, Bradley N Gaynes, Amy Heine, W Christopher Mathews, Richard Moore, Sonia Napravnik, Steven Safren, Michael J Mugavero
OBJECTIVE: To describe disparities along the depression treatment cascade, from indication for antidepressant treatment to effective treatment, in HIV-infected individuals by gender and race/ethnicity. METHODS: The Center for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) cohort includes 31,000 HIV-infected adults in routine clinical care at 8 sites. Individuals were included in the analysis if they had a depressive symptoms measure within one month of establishing HIV care at a CNICS site...
2016: PloS One
https://www.readbyqxmd.com/read/27482893/not-all-non-drinkers-with-hiv-are-equal-demographic-and-clinical-comparisons-among-current-non-drinkers-with-and-without-a-history-of-prior-alcohol-use-disorders
#19
Heidi M Crane, Robin M Nance, Joseph O Merrill, Heidi Hutton, Geetanjali Chander, Mary E McCaul, W Chris Mathews, Rob Fredericksen, Jane M Simoni, Kenneth Mayer, Michael J Mugavero, James H Willig, Greer Burkholder, Daniel R Drozd, Matthew Mimiaga, Bryan Lau, H Nina Kim, Karen Cropsey, Richard D Moore, Katerina Christopoulos, Elvin Geng, Joseph J Eron, Sonia Napravnik, Mari M Kitahata, Michael S Saag, Joseph Ac Delaney
Studies of persons living with HIV (PLWH) have compared current non-drinkers to at-risk drinkers without differentiating whether current non-drinkers had a prior alcohol use disorder (AUD). The purpose of this study was to compare current non-drinkers with and without a prior AUD on demographic and clinical characteristics to understand the impact of combining them. We included data from six sites across the US from 1/2013 to 3/2015. Patients completed tablet-based clinical assessments at routine clinic appointments using the most recent assessment...
August 2, 2016: AIDS Care
https://www.readbyqxmd.com/read/27479516/advanced-practice-nurse-led-statewide-collaborative-to-reduce-falls-in-hospitals
#20
Deanna Gray-Miceli, Lisa Mazzia, Giles Crane
Thirty-eight hospitals participated in falls prevention team training, followed by coaching and mentoring over 3 months to develop unit-based initiatives to reduce falls. Initiatives centered on fall risk assessment, rounding, or postfall assessment. Paired t test of the pre-/postintervention fall rates of 23 of the hospitals revealed reduced fall rates (P < .01). The estimated mean decrease was 1.7 falls per 1000 patient days (95% confidence limits of 0.7-2.7).
July 28, 2016: Journal of Nursing Care Quality
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