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https://www.readbyqxmd.com/read/28068240/does-unintentional-splenic-radiation-predict-outcomes-after-pancreatic-cancer-radiation-therapy
#1
Awalpreet S Chadha, Guan Liu, Hsiang-Chun Chen, Prajnan Das, Bruce D Minsky, Usama Mahmood, Marc E Delclos, Yelin Suh, Gabriel O Sawakuchi, Sam Beddar, Matthew H Katz, Jason B Fleming, Milind M Javle, Gauri R Varadhachary, Robert A Wolff, Christopher H Crane, Xuemei Wang, Howard Thames, Sunil Krishnan
PURPOSE: To determine whether severity of lymphopenia is dependent on radiation dose and fractional volume of spleen irradiated unintentionally during definitive chemoradiation (CRT) in patients with locally advanced pancreatic cancer (LAPC). METHODS: 177 patients with LAPC received induction chemotherapy (mainly gemcitabine-based regimens) followed by CRT (median 50.4 Gy with concurrent capecitabine) from January 2006 to December 2012. Absolute lymphocyte count (ALC) was recorded at baseline, before CRT, and 2 to 10 weeks after CRT...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28063631/surgical-oncology-nursing-looking-back-looking-forward
#2
REVIEW
Patrick C Crane, Louise Selanders
OBJECTIVE: To provide a historical perspective in the development of oncology nursing and surgical oncology as critical components of today's health care system. DATA SOURCES: Review of the literature and Web sites of key organizations. CONCLUSION: The evolution of surgical oncology nursing has traversed a historical journey from that of a niche subspecialty of nursing that had very little scientific underpinning, to a highly sophisticated discipline within a very short time...
January 4, 2017: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/28043175/the-promising-potential-role-of-ketones-in-inflammatory-dermatologic-disease-a-new-frontier-in-treatment-research
#3
Daren A Fomin, Brianna McDaniel, Jonathan Crane
The ketogenic diet has been shown to be beneficial for numerous diseases across different organ systems, but a dearth of information exists regarding these benefits for skin disease. Here, we searched the literature for known mechanisms behind inflammation in dermatologic disease and correlated that with suggested mechanisms of anti-inflammatory activity of ketones and a ketogenic state in the human body to observe how ketones and ketosis might aid in the treatment of inflammatory skin diseases based on these mechanisms...
January 3, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28031068/what-defines-mindfulness-based-programs-the-warp-and-the-weft
#4
R S Crane, J Brewer, C Feldman, J Kabat-Zinn, S Santorelli, J M G Williams, W Kuyken
There has been an explosion of interest in mindfulness-based programs (MBPs) such as Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Cognitive Therapy. This is demonstrated in increased research, implementation of MBPs in healthcare, educational, criminal justice and workplace settings, and in mainstream interest. For the sustainable development of the field there is a need to articulate a definition of what an MBP is and what it is not. This paper provides a framework to define the essential characteristics of the family of MBPs originating from the parent program MBSR, and the processes which inform adaptations of MBPs for different populations or contexts...
December 29, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/28012954/a-novel-haemosporida-clade-at-the-rank-of-genus-in-north-american-cranes-aves-gruiformes
#5
Miranda R Bertram, Sarah A Hamer, Barry K Hartup, Karen F Snowden, Matthew C Medeiros, Diana C Outlaw, Gabriel L Hamer
The unicellular blood parasites in the order Haemosporida are highly diverse, infect many vertebrates, are responsible for a large disease burden among humans and animals, and have reemerged as an important model system to understand the evolutionary and ecological dynamics of host-parasite interactions. The phylogenetics and systematics of Haemosporida are limited by poor sampling of different vertebrate host taxa. We surveyed the Haemosporida of wild whooping cranes (Grus americana) and sandhill cranes (Grus canadensis) (Aves: Gruiformes) using a combination of morphological and molecular approaches...
December 21, 2016: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28006972/identifying-hiv-care-enrollees-at-risk-for-cannabis-use-disorder
#6
Bryan Hartzler, Beatriz H Carlini, Howard Newville, Heidi M Crane, Joseph J Eron, Elvin H Geng, W Christopher Mathews, Kenneth H Mayer, Richard D Moore, Michael J Mugavero, Sonia Napravnik, Benigno Rodriguez, Dennis M Donovan
Increased scientific attention given to cannabis in the United States has particular relevance for its domestic HIV care population, given that evidence exists for both cannabis as a therapeutic agent and cannabis use disorder (CUD) as a barrier to antiretroviral medication adherence. It is critical to identify relative risk for CUD among demographic subgroups of HIV patients, as this will inform detection and intervention efforts. A Center For AIDS Research Network of Integrated Clinical Systems cohort (N = 10,652) of HIV-positive adults linked to care at seven United State sites was examined for this purpose...
December 23, 2016: AIDS Care
https://www.readbyqxmd.com/read/27998625/a-consensus-driven-agenda-for-emergency-medicine-firearm-injury-prevention-research
#7
Megan L Ranney, Jonathan Fletcher, Harrison Alter, Christopher Barsotti, Vikhyat S Bebarta, Marian E Betz, Patrick M Carter, Magdalena Cerdá, Rebecca M Cunningham, Peter Crane, Jahan Fahimi, Matthew J Miller, Ali Rowhani-Rahbar, Jody A Vogel, Garen J Wintemute, Manish N Shah, Muhammad Waseem
STUDY OBJECTIVE: To identify critical emergency medicine-focused firearm injury research questions and develop an evidence-based research agenda. METHODS: National content experts were recruited to a technical advisory group for the American College of Emergency Physicians Research Committee. Nominal group technique was used to identify research questions by consensus. The technical advisory group decided to focus on 5 widely accepted categorizations of firearm injury...
December 17, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27984655/local-therapy-reduces-the-risk-of-liver-failure-and-improves-survival-in-patients-with-intrahepatic-cholangiocarcinoma-a-comprehensive-analysis-of-362-consecutive-patients
#8
Suguru Yamashita, Eugene Jon Koay, Guillaume Passot, Rachna Shroff, Kanwal P Raghav, Claudius Conrad, Yun Shin Chun, Thomas A Aloia, Randa Tao, Ahmed Kaseb, Milind Javle, Christopher H Crane, Jean-Nicolas Vauthey
BACKGROUND: Treatment methods for intrahepatic cholangiocarcinoma (ICC) have improved, but their impact on outcome remains unclear. We evaluated the outcomes of patients definitively treated with resection, radiation, and chemotherapy for ICC, stratified by era. METHODS: Clinico-pathologic characteristics, cause of death, disease-specific survival (DSS), and intrahepatic progression-free survival (IPFS) were compared among patients who underwent resection, radiation, or chemotherapy as definitive treatment strategies for ICC (without distant organ metastasis) between 1997 and 2015...
December 16, 2016: Cancer
https://www.readbyqxmd.com/read/27965874/can-a-mindfulness-informed-intervention-reduce-aggressive-behaviour-in-people-with-intellectual-disabilities-protocol-for-a-feasibility-study
#9
Gemma Maria Griffith, Robert Jones, Richard Patrick Hastings, Rebecca S Crane, Judith Roberts, Jonathan Williams, Lucy Bryning, Zoe Hoare, Rhiannon Tudor Edwards
BACKGROUND: Approximately 10-20 % of adults with intellectual disabilities engage in challenging behaviours such as aggression, destructiveness, and self-injury, which are often accompanied by feelings of anger. The inability to manage anger can reduce quality of life. For example, aggression is a strong predictor of out-of-area placements and is a risk variable for abuse. Recent research suggests that mindfulness-based therapies (specifically, Singh's Soles of the Feet meditation) can help people with intellectual disabilities manage angry emotions, with resultant reductions in challenging behaviour...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27933810/structure-based-scaffold-repurposing-for-g-protein-coupled-receptors-transformation-of-adenosine-derivatives-into-5ht2b-5ht2c-serotonin-receptor-antagonists
#10
Dilip K Tosh, Antonella Ciancetta, Eugene Warnick, Steven Crane, Zhan-Guo Gao, Kenneth A Jacobson
Adenosine derivatives developed to activate adenosine receptors (ARs) revealed micromolar activity at serotonin 5HT2B and 5HT2C receptors (5HTRs). We explored the structure-activity relationship at 5HT2Rs and modeled receptor interactions in order to optimize affinity and simultaneously reduce AR affinity. Depending on N(6) substitution, small 5'-alkylamide modification maintained 5HT2BR affinity, which was enhanced upon ribose substitution with rigid bicyclo[3.1.0]hexane (North (N)-methanocarba), e.g., N(6)-dicyclopropylmethyl 4'-CH2OH derivative 14 (Ki 11 nM)...
December 22, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27923968/exploring-gender-differences-in-a-randomized-trial-of-weight-loss-maintenance
#11
Melissa M Crane, Robert W Jeffery, Nancy E Sherwood
The purpose of this study is to explore gender differences in reasons for losing weight, weight loss methods, and weight loss behaviors prior to and during a weight loss maintenance trial. This is a secondary analysis of data from a 24-month randomized controlled trial comparing Self-Directed or Guided phone-based weight loss maintenance interventions among adults who had intentionally lost ≥10% of their body weight in the year prior to enrollment. Participants reported their weight loss methods and reasons for recently losing weight at baseline...
December 5, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27866734/comparing-variability-severity-and-persistence-of-depressive-symptoms-as-predictors-of-future-stroke-risk
#12
Laura B Zahodne, Paola Gilsanz, M Maria Glymour, Laura E Gibbons, Paul Brewster, Jamie Hamilton, Jesse Mez, Jessica R Marden, Kwangsik Nho, Eric B Larson, Paul K Crane, Alden L Gross
OBJECTIVE: Numerous studies show that depressive symptoms measured at a single assessment predict greater future stroke risk. Longer-term symptom patterns, such as variability across repeated measures or worst symptom level, might better reflect adverse aspects of depression than a single measurement. This prospective study compared five approaches to operationalizing depressive symptoms at annual assessments as predictors of stroke incidence. DESIGN: Cohort followed for incident stroke over an average of 6...
October 24, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27807656/preliminary-characterization-of-tasmanian-aquareovirus-tsrv-isolates
#13
Sandra C Zainathan, Jeremy Carson, Mark St J Crane, Lynette M Williams, John Hoad, Nicholas J G Moody, Nicholas Gudkovs, Sandra Crameri, Alex D Hyatt, John Young, Barbara F Nowak
In an attempt to determine whether or not genetic variants of the Tasmanian strain of Atlantic salmon aquareovirus (TSRV) exist, 14 isolates of TSRV, originating from various locations in Tasmania, covering a 20-year period (1990-2010), obtained from various host species and tissues, and isolated on different cell lines, were selected for this study. Two categories, termed "typical" and "atypical", of variants of TSRV were identified based on preliminary genotypic and phenotypic characterization carried out on these 14 different isolates...
November 2, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27806937/evaluation-of-a-protocol-to-optimize-duration-of-pneumonia-therapy-at-hospital-discharge
#14
Christina Caplinger, Kendall Crane, Michelle Wilkin, Jefferson Bohan, Richard Remington, Karl Madaras-Kelly
PURPOSE: A protocol to optimize the duration of antimicrobial therapy (DAT) for uncomplicated pneumonia at hospital discharge was evaluated. METHODS: This retrospective quasiexperimental study was conducted at Boise Veterans Affairs Medical Center from March 2013 through June 2015. Patients were included in the study if they were diagnosed with pneumonia, were hospitalized for more than 24 hours, received antimicrobial treatment within 48 hours of admission, and survived until hospital discharge...
December 15, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27803157/bacterial-energy-sensor-aer-modulates-the-activity-of-the-chemotaxis-kinase-chea-based-on-the-redox-state-of-the-flavin-cofactor
#15
Dipanjan Samanta, Joanne Widom, Peter P Borbat, Jack H Freed, Brian R Crane
Flagellated bacteria modulate their swimming behavior in response to environmental cues through the CheA/CheY signaling pathway. In addition to responding to external chemicals, bacteria also monitor internal conditions that reflect the availability of oxygen, light, and reducing equivalents, in a process termed "energy taxis." In Escherichia coli, the transmembrane receptor Aer is the primary energy sensor for motility. Genetic and physiological data suggest that Aer monitors the electron transport chain through the redox state of its FAD cofactor...
December 9, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27801957/a-new-marker-based-on-the-avian-spindlin-gene-that-is-able-to-sex-most-birds-including-species-problematic-to-sex-with-chd-markers
#16
Deborah A Dawson, Natalie Dos Remedios, Gavin J Horsburgh
We have developed a new marker (Z43B) that can be successfully used to identify the sex of most birds (69%), including species difficult or impossible to sex with other markers. We utilized the zebra finch Taeniopygia guttata EST microsatellite sequence (CK309496) which displays sequence homology to the 5' untranslated region (UTR) of the avian spindlin gene. This gene is known to be present on the Z and W chromosomes. To maximize cross-species utility, the primer set was designed from a consensus sequence created from homologs of CK309496 that were isolated from multiple distantly related species...
November 2016: Zoo Biology
https://www.readbyqxmd.com/read/27758144/genetically-engineered-macrophages-a-potential-platform-for-cancer-immunotherapy
#17
Kara W Moyes, Nicole A P Lieberman, Shannon A Kreuser, Harrison Chinn, Conrad Winter, Gail Deutsch, Virginia Hoglund, Reid Watson, Courtney A Crane
In spite of their successes against hematologic malignancies, immunotherapeutic interventions for the treatment of patients with glioblastoma (GBM) have thus far been unsuccessful. This is in part due to the presence of a tumor microenvironment that fosters neoplastic growth and protects the tumor from destruction by the immune system. A novel genetically engineered macrophage-based platform has been developed with the potential to minimize the effects of the suppressive tumor microenvironment and improve innate and adaptive antitumor immune responses...
October 18, 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27745683/understanding-and-promoting-effective-engagement-with-digital-behavior-change-interventions
#18
Lucy Yardley, Bonnie J Spring, Heleen Riper, Leanne G Morrison, David H Crane, Kristina Curtis, Gina C Merchant, Felix Naughton, Ann Blandford
This paper is one in a series developed through a process of expert consensus to provide an overview of questions of current importance in research into engagement with digital behavior change interventions, identifying guidance based on research to date and priority topics for future research. The first part of this paper critically reflects on current approaches to conceptualizing and measuring engagement. Next, issues relevant to promoting effective engagement are discussed, including how best to tailor to individual needs and combine digital and human support...
November 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27745681/the-pace-of-technologic-change-implications-for-digital-health-behavior-intervention-research
#19
Kevin Patrick, Eric B Hekler, Deborah Estrin, David C Mohr, Heleen Riper, David Crane, Job Godino, William T Riley
This paper addresses the rapid pace of change in the technologies that support digital interventions; the complexity of the health problems they aim to address; and the adaptation of scientific methods to accommodate the volume, velocity, and variety of data and interventions possible from these technologies. Information, communication, and computing technologies are now part of every societal domain and support essentially every facet of human activity. Ubiquitous computing, a vision articulated fewer than 30 years ago, has now arrived...
November 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27707688/a-randomized-controlled-trial-protocol-to-evaluate-the-effectiveness-of-an-integrated-care-management-approach-to-improve-adherence-among-hiv-infected-patients-in-routine-clinical-care-rationale-and-design
#20
Heidi M Crane, Rob J Fredericksen, Anna Church, Anna Harrington, Paul Ciechanowski, Jennifer Magnani, Kari Nasby, Tyler Brown, Shireesha Dhanireddy, Robert D Harrington, William B Lober, Jane Simoni, Stevan A Safren, Todd C Edwards, Donald L Patrick, Michael S Saag, Paul K Crane, Mari M Kitahata
BACKGROUND: Adherence to antiretroviral medications is a key determinant of clinical outcomes. Many adherence intervention trials investigated the effects of time-intensive or costly interventions that are not feasible in most clinical care settings. OBJECTIVE: We set out to evaluate a collaborative care approach as a feasible intervention applicable to patients in clinical care including those with mental illness and/or substance use issues. METHODS: We developed a randomized controlled trial (RCT) investigating an integrated, clinic-based care management approach to improve clinical outcomes that could be integrated into the clinical care setting...
October 5, 2016: JMIR Research Protocols
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