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Kara W Moyes, Nicole Ap Lieberman, Shannon A Kreuser, Harrison Chinn, Conrad Winter, Gail Deutsch, Virginia Hoglund, Reid Watson, Courtney A Crane
In spite of their successes against hematologic malignancies, immunotherapeutic interventions for the treatment of patients with glioblastoma (GBM) have thus far been unsuccessful. This is in part due to the presence of a tumor microenvironment that fosters neoplastic growth and protects the tumor from destruction by the immune system. We have developed a novel genetically engineered macrophage-based platform with the potential to minimize the effects of the suppressive tumor microenvironment and improve innate and adaptive anti-tumor immune responses...
October 19, 2016: Human Gene Therapy
Lucy Yardley, Bonnie J Spring, Heleen Riper, Leanne G Morrison, David H Crane, Kristina Curtis, Gina C Merchant, Felix Naughton, Ann Blandford
This paper is one in a series developed through a process of expert consensus to provide an overview of questions of current importance in research into engagement with digital behavior change interventions, identifying guidance based on research to date and priority topics for future research. The first part of this paper critically reflects on current approaches to conceptualizing and measuring engagement. Next, issues relevant to promoting effective engagement are discussed, including how best to tailor to individual needs and combine digital and human support...
November 2016: American Journal of Preventive Medicine
Kevin Patrick, Eric B Hekler, Deborah Estrin, David C Mohr, Heleen Riper, David Crane, Job Godino, William T Riley
This paper addresses the rapid pace of change in the technologies that support digital interventions; the complexity of the health problems they aim to address; and the adaptation of scientific methods to accommodate the volume, velocity, and variety of data and interventions possible from these technologies. Information, communication, and computing technologies are now part of every societal domain and support essentially every facet of human activity. Ubiquitous computing, a vision articulated fewer than 30 years ago, has now arrived...
November 2016: American Journal of Preventive Medicine
Heidi M Crane, Rob J Fredericksen, Anna Church, Anna Harrington, Paul Ciechanowski, Jennifer Magnani, Kari Nasby, Tyler Brown, Shireesha Dhanireddy, Robert D Harrington, William B Lober, Jane Simoni, Stevan A Safren, Todd C Edwards, Donald L Patrick, Michael S Saag, Paul K Crane, Mari M Kitahata
BACKGROUND: Adherence to antiretroviral medications is a key determinant of clinical outcomes. Many adherence intervention trials investigated the effects of time-intensive or costly interventions that are not feasible in most clinical care settings. OBJECTIVE: We set out to evaluate a collaborative care approach as a feasible intervention applicable to patients in clinical care including those with mental illness and/or substance use issues. METHODS: We developed a randomized controlled trial (RCT) investigating an integrated, clinic-based care management approach to improve clinical outcomes that could be integrated into the clinical care setting...
October 5, 2016: JMIR Research Protocols
Andrew T Placzek, Skylar J Ferrara, Meredith D Hartley, Hannah S Sanford-Crane, J Matthew Meinig, Thomas S Scanlan
There is currently great interest in developing drugs that stimulate myelin repair for use in demyelinating diseases such as multiple sclerosis. Thyroid hormone plays a key role in stimulating myelination during development and also controls the expression of important genes involved in myelin repair in adults. Because endogenous thyroid hormone in excess lacks a generally useful therapeutic index, it is not used clinically for indications other than hormone replacement; however, selective thyromimetics such as sobetirome offer a therapeutic alternative...
September 16, 2016: Bioorganic & Medicinal Chemistry
Ildiko Tombor, Lion Shahab, Jamie Brown, David Crane, Susan Michie, Robert West
Pregnant smokers may benefit from digital smoking cessation interventions, but few have been designed for this population. The aim was to transparently report the development of a smartphone app designed to aid smoking cessation during pregnancy. The development of a smartphone app ('SmokeFree Baby') to help pregnant women stop smoking was guided by frameworks for developing complex interventions, including the Medical Research Council (MRC), Multiphase Optimization Strategy (MOST) and Behaviour Change Wheel (BCW)...
October 3, 2016: Translational Behavioral Medicine
Caroline J Easton, Cory A Crane
The social and economic cost of intimate partner violence (IPV) is exorbitant and highlights the need for policy reform as it pertains to IPV interventions at a global level. There are multiple variables associated with the aetiology of IPV and, hence, multiple treatment needs must be considered. Substance use is one of several factors likely to influence the occurrence of IPV, but often goes unaddressed in standard treatment approaches. This review will discuss several treatment models for substance using offenders of IPV, including Psycho-educational Models, Cognitive Behavioural Therapy, Couples' Treatments, Parenting Programmes, Integration of Care Models, and Pharmacotherapies...
October 2016: International Review of Psychiatry
Takuya Akiyama, Chizuko Nishida, Kunikazu Momose, Manabu Onuma, Kazutoshi Takami, Ryuichi Masuda
The gene duplication in mitochondrial DNA (mtDNA) has been reported in diverse bird taxa so far. Although many phylogenetic and population genetic analyses of cranes were carried out based on mtDNA diversity, whether mtDNA contains duplicated regions is unknown. To address the presence or absence of gene duplication in cranes and investigate the molecular evolutionary features of crane mtDNA, we analyzed the gene organization and the molecular phylogeny of mtDNA from 13 crane species. We found that the mtDNA in 13 crane species shared a tandem duplicated region, which consists of duplicated sequence sets including cytochrome b (Cytb), NADH6, control region (CR) and three genes of tRNA...
September 28, 2016: Molecular Phylogenetics and Evolution
Michael R Miller, Kelly A Miller, Jiang Bian, Milinda E James, Sheng Zhang, Michael J Lynch, Patrick S Callery, Justin M Hettick, Andrew Cockburn, Jun Liu, Chunhao Li, Brian R Crane, Nyles W Charon
Spirochaetes are bacteria responsible for several serious diseases, including Lyme disease (Borrelia burgdorferi), syphilis (Treponema pallidum) and leptospirosis (Leptospira interrogans), and contribute to periodontal diseases (Treponema denticola)(1). These spirochaetes employ an unusual form of flagella-based motility necessary for pathogenicity; indeed, spirochaete flagella (periplasmic flagella) reside and rotate within the periplasmic space(2-11). The universal joint or hook that links the rotary motor to the filament is composed of ∼120-130 FlgE proteins, which in spirochaetes form an unusually stable, high-molecular-weight complex(9,12-17)...
2016: Nature Microbiology
Angela M Bengtson, Brian W Pence, Bradley N Gaynes, E Byrd Quinlivan, Amy D Heine, Julie K O'Donnell, Heidi M Crane, W Christopher Mathews, Richard D Moore, Daniel Westreich, Conall O'Cleirigh, Katerina Christopoulos, Matthew J Mimiaga, Michael J Mugavero
BACKGROUND: Depression affects 20-30% of people with HIV. Randomized controlled trials (RCTs) have demonstrated the effectiveness of interventions to improve depression among HIV-infected adults, but typically have highly selected populations which may limit generalizability. Inverse probability of sampling weights (IPSW) are a recently proposed method to transport (or standardize) findings from RCTs to a specific external target population. METHODS: We used IPSW to transport the 6-month effect of the Measurement-Based Care (MBC) intervention on depression from the SLAM DUNC trial to a population of HIV-infected depressed adults in routine care in the United States between 2010 and 2014...
July 12, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Miroslav B Milovanović, Dragan S Antić, Marko T Milojković, Saša S Nikolić, Staniša Lj Perić, Miodrag D Spasić
A new intelligent hybrid structure used for online tuning of a PID controller is proposed in this paper. The structure is based on two adaptive neural networks, both with built-in Chebyshev orthogonal polynomials. First substructure network is a regular orthogonal neural network with implemented artificial endocrine factor (OENN), in the form of environmental stimuli, to its weights. It is used for approximation of control signals and for processing system deviation/disturbance signals which are introduced in the form of environmental stimuli...
September 5, 2016: Neural Networks: the Official Journal of the International Neural Network Society
Treena I Burgess, John K Scott, Keith L Mcdougall, Michael J C Stukely, Colin Crane, William A Dunstan, Frances Brigg, Vera Andjic, Diane White, Tim Rudman, Frans Arentz, Noboru Ota, Giles E St J Hardy
Globally, Phytophthora cinnamomi is listed as one of the 100 worst invasive alien species and active management is required to reduce impact and prevent spread in both horticulture and natural ecosystems. Conversely, there are regions thought to be suitable for the pathogen where no disease is observed. We developed a climex model for the global distribution of P. cinnamomi based on the pathogen's response to temperature and moisture and by incorporating extensive empirical evidence on the presence and absence of the pathogen...
September 6, 2016: Global Change Biology
Angela M Bengtson, Brian W Pence, Heidi M Crane, Katerina Christopoulos, Rob J Fredericksen, Bradley N Gaynes, Amy Heine, W Christopher Mathews, Richard Moore, Sonia Napravnik, Steven Safren, Michael J Mugavero
OBJECTIVE: To describe disparities along the depression treatment cascade, from indication for antidepressant treatment to effective treatment, in HIV-infected individuals by gender and race/ethnicity. METHODS: The Center for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) cohort includes 31,000 HIV-infected adults in routine clinical care at 8 sites. Individuals were included in the analysis if they had a depressive symptoms measure within one month of establishing HIV care at a CNICS site...
2016: PloS One
Heidi M Crane, Robin M Nance, Joseph O Merrill, Heidi Hutton, Geetanjali Chander, Mary E McCaul, W Chris Mathews, Rob Fredericksen, Jane M Simoni, Kenneth Mayer, Michael J Mugavero, James H Willig, Greer Burkholder, Daniel R Drozd, Matthew Mimiaga, Bryan Lau, H Nina Kim, Karen Cropsey, Richard D Moore, Katerina Christopoulos, Elvin Geng, Joseph J Eron, Sonia Napravnik, Mari M Kitahata, Michael S Saag, Joseph Ac Delaney
Studies of persons living with HIV (PLWH) have compared current non-drinkers to at-risk drinkers without differentiating whether current non-drinkers had a prior alcohol use disorder (AUD). The purpose of this study was to compare current non-drinkers with and without a prior AUD on demographic and clinical characteristics to understand the impact of combining them. We included data from six sites across the US from 1/2013 to 3/2015. Patients completed tablet-based clinical assessments at routine clinic appointments using the most recent assessment...
August 2, 2016: AIDS Care
Deanna Gray-Miceli, Lisa Mazzia, Giles Crane
Thirty-eight hospitals participated in falls prevention team training, followed by coaching and mentoring over 3 months to develop unit-based initiatives to reduce falls. Initiatives centered on fall risk assessment, rounding, or postfall assessment. Paired t test of the pre-/postintervention fall rates of 23 of the hospitals revealed reduced fall rates (P < .01). The estimated mean decrease was 1.7 falls per 1000 patient days (95% confidence limits of 0.7-2.7).
July 28, 2016: Journal of Nursing Care Quality
Xu Hu, Nina M Richtman, Jian-Zhou Zhao, Keith E Duncan, Xiping Niu, Lisa A Procyk, Meghan A Oneal, Bliss M Kernodle, Joseph P Steimel, Virginia C Crane, Gary Sandahl, Julie L Ritland, Richard J Howard, James K Presnail, Albert L Lu, Gusui Wu
RNA interference (RNAi) is a promising new technology for corn rootworm control. This paper presents the discovery of new gene targets - dvssj1 and dvssj2, in western corn rootworm (WCR). Dvssj1 and dvssj2 are orthologs of the Drosophila genes snakeskin (ssk) and mesh, respectively. These genes encode membrane proteins associated with smooth septate junctions (SSJ) which are required for intestinal barrier function. Based on bioinformatics analysis, dvssj1 appears to be an arthropod-specific gene. Diet based insect feeding assays using double-stranded RNA (dsRNA) targeting dvssj1 and dvssj2 demonstrate targeted mRNA suppression, larval growth inhibition, and mortality...
2016: Scientific Reports
Carolyn Crane Cutilli
Healthcare professionals teach patients and families about their health every day. Regulatory and accreditation organizations mandate patient and family education to promote better health outcomes. And recently, financial rewards for healthcare organizations are being tied to patient satisfaction (Hospital Consumer Assessment of Healthcare Providers and Systems-HCAHPS). A University of Pennsylvania Health System group of staff and patients, devoted to excellence in patient and family education, developed the graphic "R...
July 2016: Orthopaedic Nursing
David Rodriguez, Saibal Chakraborty, Eugene Warnick, Steven Crane, Zhan-Guo Gao, Robert D O'Connor, Kenneth A Jacobson, Jens Carlsson
Small molecule screening libraries cover only a small fraction of astronomical number of possible drug-like compounds, limiting the success of ligand discovery efforts. Computational screening of virtual libraries representing unexplored chemical space could potentially bridge this gap. Drug development for adenosine receptors (ARs) as targets for inflammation and cardiovascular diseases has been hampered by the paucity of agonist scaffolds. To identify novel AR agonists, a virtual library of synthetically tractable nucleosides with alternative bases was generated and structure-based virtual screening guided selection of compounds for synthesis...
July 20, 2016: ACS Chemical Biology
Xianqing Wu, Xiongxiong He
In this paper, a novel anti-swing control method is proposed for 3-dimensional (3-D) underactuated overhead crane systems, which guarantees fast transportation and efficient swing suppression. Specifically, to increase the performance of the payload swing suppression, a swing-suppressing element is introduced, based on which a novel positioning error signal is constructed. Then, a new control method is developed, and the overall system is divided into two subsystems. The stability analysis of the two subsystems and the overall system is given...
July 15, 2016: ISA Transactions
Katrina F Trivers, Juan L Rodriguez, Summer L Cox, Barbara E Crane, Debra Duquette
In 2011, the Division of Cancer Prevention and Control (DCPC), at the United States Centers for Disease Control and Prevention (CDC), released a three-year funding opportunity announcement (FOA) for a competitive, non-research cooperative agreement. The agreement enhanced the capacities of state health departments to promote the application of best practices for evidence-based breast cancer genomics through education, surveillance, and policy activities. The FOA required that applicants focus on activities related to hereditary breast and ovarian cancer (HBOC)...
2015: Healthcare (Basel, Switzerland)
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