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https://www.readbyqxmd.com/read/28548835/rapid-deposition-of-uniform-polydopamine-coatings-on-nanoparticle-surfaces-with-controllable-thickness
#1
Nazar Orishchin, Cameron C Crane, Matthew Brownell, Tengjiao Wang, Samuel Jenkins, Min Zou, Arun Nair, Jingyi Chen
Polydopamine is a bioinspired, versatile material that can adhere to bulk and nanoscale surfaces made of disparate materials to improve their physical and chemical properties in many applications. The typical methods to coat polydopamine on the nanoparticle substrates usually take several hours to a day. This work successfully applies a dispersion method to form a controllable, uniform coating on a nanoparticle surface within minutes. Using plasmonic Ag nanoparticles as a substrate, the coating thickness can be monitored using a spectroscopic method based on the extinction peak shifts of the Ag nanoparticles...
May 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28543062/an-adaptive-vestibular-rehabilitation-technique
#2
Benjamin T Crane, Michael C Schubert
OBJECTIVES/HYPOTHESIS: There is a large variation in vestibular rehabilitation (VR) results depending on type of therapy, adherence, and the appropriateness for the patient's level of function. A novel adaptive vestibular rehabilitation (AVR) program was developed and evaluated. STUDY DESIGN: Technology and procedure development, and prospective multicenter trial. METHODS: Those with complete unilateral vestibular hypofunction and symptomatic at least 3 months with a Dizziness Handicap Inventory (DHI) >30 were eligible...
May 23, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28537858/portable-equipment-for-taking-dramatic-sun-damage-revealing-photos-at-skin-cancer-prevention-outreach-events
#3
Jessica S Mounessa, Neil F Box, Nancy L Asdigian, Taylor Braunberger, Cory A Dunnick, Lori A Crane, Robert R Dellavalle
In recent years, appearance-based interventions have gained popularity as a means to improve public awareness about skin cancer and sun protective behaviors. Although numerous reports discuss the use of ultraviolet (UV) camera devices for this purpose,studies on the use of portable imaging devices in community outreach events do not presently exist. In this report, we discuss how we successfully utilize portable imaging devices at community outreach events. We also discuss the advantages and disadvantages of our portable devices in comparison to traditional UV cameras...
May 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28527330/home-practice-in-mindfulness-based-cognitive-therapy-and-mindfulness-based-stress-reduction-a-systematic-review-and-meta-analysis-of-participants-mindfulness-practice-and-its-association-with-outcomes
#4
Christine E Parsons, Catherine Crane, Liam J Parsons, Lone Overby Fjorback, Willem Kuyken
Mindfulness-Based Cognitive Therapy (MBCT) and Mindfulness-Based Stress Reduction (MBSR) emphasize the importance of mindfulness practice at home as an integral part of the program. However, the extent to which participants complete their assigned practice is not yet clear, nor is it clear whether this practice is associated with positive outcomes. For this systematic review and meta-analysis, searches were performed using Scopus and PubMed for studies published through to the end of 2015, reporting on formal home practice of mindfulness by MBSR or MBCT participants...
May 10, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28515799/implementing-mindfulness-in-the-mainstream-making-the-path-by-walking-it
#5
Rebecca S Crane
There is expanding interest in mindfulness-based programs (MBPs) within the mainstream. While there are research gaps, there is empirical evidence for these developments. Implementing new evidence into practice is always complex and difficult. Particular complexities and tensions arise when implementing MBPs in the mainstream. MBPs are emerging out of the confluence of different epistemologies-contemplative teaching and practice, and contemporary Western empiricism and culture. In the process of navigating implementation and integrity, and developing a professional practice context for this emerging field, the diverse influences within this confluence need careful attention and thought...
2017: Mindfulness
https://www.readbyqxmd.com/read/28501972/genetic-variation-of-major-histocompatibility-complex-genes-in-the-endangered-red-crowned-crane
#6
Takuya Akiyama, Tetsuo I Kohyama, Chizuko Nishida, Manabu Onuma, Kunikazu Momose, Ryuichi Masuda
Populations that have drastically decreased in the past often have low genetic variation, which may increase the risk of extinction. The genes of major histocompatibility complex (MHC) play an important role in the adaptive immune response of jawed vertebrates. Maintenance of adaptive genetic diversity such as that of MHC genes is important for wildlife conservation. Here, we determined genotypes of exon 3 of MHC class IA genes (MHCIA) and exon 2 of MHC class IIB genes (MHCIIB) to evaluate genetic variation of the endangered red-crowned crane population on Hokkaido Island, Japan, which experienced severe population decline in the past...
May 14, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28499571/designing-an-internet-intervention-for-emerging-adults-who-experience-troubled-relationships
#7
Claire Burke Draucker, Donna S Martsolf, Stacey Crane, Lindsey Romero, Allison Leigh McCord
This article describes how the Internet Intervention Model (IIM) was used as an organizing framework to design a theoretically based Internet intervention for emerging adults who experience troubled intimate partner relationships. In the design process, the team addressed six fundamental questions related to the several components of the IIM. Decisions made regarding the design of the intervention based on the six questions are described. We focus in particular on how the intervention is based on the Theory of Emerging Adulthood and the Theory of Narrative Identity...
June 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28498892/incident-aids-or-death-after-initiation-of-human-immunodeficiency-virus-treatment-regimens-including-raltegravir-or-efavirenz-among-adults-in-the-united-states
#8
Stephen R Cole, Jessie K Edwards, H Irene Hall, M Alan Brookhart, W Christopher Mathews, Richard D Moore, Heidi M Crane, Mari M Kitahata, Michael J Mugavero, Michael S Saag, Joseph J Eron
Background.: The long-term effectiveness of human immunodeficiency virus (HIV) treatments containing integrase inhibitors is unknown. Methods.: We use observational data from the Centers for AIDS Research Network of Integrated Clinical Systems and the Centers for Disease Control and Prevention to estimate 4-year risk of AIDS and all-cause mortality among 415 patients starting a raltegravir regimen compared to 2646 starting an efavirenz regimen (both regimens include emtricitabine and tenofovir disoproxil fumarate)...
June 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28470861/fully-automated-atlas-based-method-for-prescribing-3d-press-mr-spectroscopic-imaging-toward-robust-and-reproducible-metabolite-measurements-in-human-brain
#9
Wei Bian, Yan Li, Jason C Crane, Sarah J Nelson
PURPOSE: To implement a fully automated atlas-based method for prescribing 3D PRESS MR spectroscopic imaging (MRSI). METHODS: The PRESS selected volume and outer-volume suppression bands were predefined on the MNI152 standard template image. The template image was aligned to the subject T1 -weighted image during a scan, and the resulting transformation was then applied to the predefined prescription. To evaluate the method, H-1 MRSI data were obtained in repeat scan sessions from 20 healthy volunteers...
May 3, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28453469/use-of-analgesics-opioids-and-nonsteroidal-anti-inflammatory-drugs-and-dementia-related-neuropathology-in-a-community-based-autopsy-cohort
#10
Sascha Dublin, Rod L Walker, Shelly L Gray, Rebecca A Hubbard, Melissa L Anderson, Onchee Yu, Thomas J Montine, Paul K Crane, Josh A Sonnen, Eric B Larson
BACKGROUND: Opioids may influence the development of Alzheimer's disease (AD). Some studies have observed AD pathology in the brains of opioid abusers. No study has examined the association between prescription opioid use and dementia-related neuropathologic changes. OBJECTIVE: To examine the relationship between prescription opioid or NSAID use and dementia-related neuropathologic changes. METHODS: Within a community-based autopsy cohort (N = 420), we ascertained opioid and nonsteroidal anti-inflammatory drug (NSAID) use over a 10-year period from automated pharmacy data and calculated total standardized daily doses (TSDDs)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28446223/the-effectiveness-and-cost-effectiveness-of-a-mindfulness-training-programme-in-schools-compared-with-normal-school-provision-myriad-study-protocol-for-a-randomised-controlled-trial
#11
Willem Kuyken, Elizabeth Nuthall, Sarah Byford, Catherine Crane, Tim Dalgleish, Tamsin Ford, Mark T Greenberg, Obioha C Ukoumunne, Russell M Viner, J Mark G Williams
BACKGROUND: Mindfulness-based approaches for adults are effective at enhancing mental health, but few controlled trials have evaluated their effectiveness or cost-effectiveness for young people. The primary aim of this trial is to evaluate the effectiveness and cost-effectiveness of a mindfulness training (MT) programme to enhance mental health, wellbeing and social-emotional behavioural functioning in adolescence. METHODS/DESIGN: To address this aim, the design will be a superiority, cluster randomised controlled, parallel-group trial in which schools offering social and emotional provision in line with good practice (Formby et al...
April 26, 2017: Trials
https://www.readbyqxmd.com/read/28441330/real-time-telemetry-system-for-monitoring-motion-of-ships-based-on-inertial-sensors
#12
José M Núñez, Marta G Araújo, I García-Tuñón
A telemetry system for real-time monitoring of the motions, position, speed and course of a ship at sea is presented in this work. The system, conceived as a subsystem of a radar cross-section measurement unit, could also be used in other applications as ships dynamics characterization, on-board cranes, antenna stabilizers, etc. This system was designed to be stand-alone, reliable, easy to deploy, low-cost and free of requirements related to stabilization procedures. In order to achieve such a unique combination of functionalities, we have developed a telemetry system based on redundant inertial and magnetic sensors and GPS (Global Positioning System) measurements...
April 25, 2017: Sensors
https://www.readbyqxmd.com/read/28411091/comparison-of-dynamic-monitoring-strategies-based-on-cd4-cell-counts-in-virally-suppressed-hiv-positive-individuals-on-combination-antiretroviral-therapy-in-high-income-countries-a-prospective-observational-study
#13
Ellen C Caniglia, Lauren E Cain, Caroline A Sabin, James M Robins, Roger Logan, Sophie Abgrall, Michael J Mugavero, Sonia Hernández-Díaz, Laurence Meyer, Remonie Seng, Daniel R Drozd, George R Seage, Fabrice Bonnet, Francois Dabis, Richard D Moore, Peter Reiss, Ard van Sighem, William C Mathews, Julia Del Amo, Santiago Moreno, Steven G Deeks, Roberto Muga, Stephen L Boswell, Elena Ferrer, Joseph J Eron, Sonia Napravnik, Sophie Jose, Andrew Phillips, Amy C Justice, Janet P Tate, John Gill, Antonio Pacheco, Valdilea G Veloso, Heiner C Bucher, Matthias Egger, Hansjakob Furrer, Kholoud Porter, Giota Touloumi, Heidi Crane, Jose M Miro, Jonathan A Sterne, Dominique Costagliola, Michael Saag, Miguel A Hernán
BACKGROUND: Clinical guidelines vary with respect to the optimal monitoring frequency of HIV-positive individuals. We compared dynamic monitoring strategies based on time-varying CD4 cell counts in virologically suppressed HIV-positive individuals. METHODS: In this observational study, we used data from prospective studies of HIV-positive individuals in Europe (France, Greece, the Netherlands, Spain, Switzerland, and the UK) and North and South America (Brazil, Canada, and the USA) in The HIV-CAUSAL Collaboration and The Centers for AIDS Research Network of Integrated Clinical Systems...
April 11, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28402881/stability-and-conformation-of-a-chemoreceptor-hamp-domain-chimera-correlates-with-signaling-properties
#14
Nattakan Sukomon, Joanne Widom, Peter P Borbat, Jack H Freed, Brian R Crane
HAMP domains are dimeric, four-helix bundles that transduce conformational signals in bacterial receptors. Genetic studies of the Escherichia coli serine receptor (Tsr) provide an opportunity to understand HAMP conformational behavior in terms of functional output. To increase its stability, the Tsr HAMP domain was spliced into a poly-HAMP unit from the Pseudomonas aeruginosa Aer2 receptor. Within the chimera, the Tsr HAMP undergoes a thermal melting transition at a temperature much lower than that of the Aer2 HAMP domains...
April 11, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28400526/plasmodium-falciparum-k13-mutations-differentially-impact-ozonide-susceptibility-and-parasite-fitness-in-vitro
#15
Judith Straimer, Nina F Gnädig, Barbara H Stokes, Michelle Ehrenberger, Audrey A Crane, David A Fidock
The emergence and spread in Southeast Asia of Plasmodium falciparum resistance to artemisinin (ART) derivatives, the cornerstone of first-line artemisinin-based combination therapies (ACTs), underscore the urgent need to identify suitable replacement drugs. Discovery and development efforts have identified a series of ozonides with attractive chemical and pharmacological properties that are being touted as suitable replacements. Partial resistance to ART, defined as delayed parasite clearance in malaria patients treated with an ART derivative or an ACT, has been associated with mutations in the P...
April 11, 2017: MBio
https://www.readbyqxmd.com/read/28398792/tobacco-town-computational-modeling-of-policy-options-to-reduce-tobacco-retailer-density
#16
Douglas A Luke, Ross A Hammond, Todd Combs, Amy Sorg, Matt Kasman, Austen Mack-Crane, Kurt M Ribisl, Lisa Henriksen
OBJECTIVES: To identify the behavioral mechanisms and effects of tobacco control policies designed to reduce tobacco retailer density. METHODS: We developed the Tobacco Town agent-based simulation model to examine 4 types of retailer reduction policies: (1) random retailer reduction, (2) restriction by type of retailer, (3) limiting proximity of retailers to schools, and (4) limiting proximity of retailers to each other. The model examined the effects of these policies alone and in combination across 4 different types of towns, defined by 2 levels of population density (urban vs suburban) and 2 levels of income (higher vs lower)...
May 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28385597/ester-to-amide-rearrangement-of-ethanolamine-derived-prodrugs-of-sobetirome-with-increased-blood-brain-barrier-penetration
#17
Skylar J Ferrara, J Matthew Meinig, Andrew T Placzek, Tapasree Banerji, Peter McTigue, Meredith D Hartley, Hannah S Sanford-Crane, Tania Banerji, Dennis Bourdette, Thomas S Scanlan
Current therapeutic options for treating demyelinating disorders such as multiple sclerosis (MS) do not stimulate myelin repair, thus creating a clinical need for therapeutic agents that address axonal remyelination. Thyroid hormone is known to play an important role in promoting developmental myelination and repair, and CNS permeable thyromimetic agents could offer an increased therapeutic index compared to endogenous thyroid hormone. Sobetirome is a clinical stage thyromimetic that has been shown to have promising activity in preclinical models related to MS and X-linked adrenoleukodystrophy (X-ALD), a genetic disease that involves demyelination...
May 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28379119/real-world-emissions-of-in-use-off-road-vehicles-in-mexico
#18
Miguel Zavala, Jose Ignacio Huertas, Daniel Prato, Aron Jazcilevich, Andrés Aguilar, Marco Balam, Chandan Misra, Luisa T Molina
Off-road vehicles used in construction and agricultural activities can contribute substantially to emissions of gaseous pollutants and can be a major source of submicron carbonaceous particles in many parts of the world. However, there have been relatively few efforts in quantifying the emission factors (EFs) as well as for estimating the potential emission reduction benefits using emission control technologies for these vehicles. This study characterized the black carbon (BC) component of particulate matter and NOx, CO, and CO2 EFs of selected diesel-powered off-road mobile sources in Mexico under real-world operating conditions using on-board portable emissions measurements systems (PEMS)...
April 5, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28373078/objective-measurement-of-clinical-competency-in-surgical-education-using-electrodermal-activity
#19
Jacob A Quick, Alex D Bukoski, Jennifer Doty, Bethany J Bennett, Megan Crane, Stephen L Barnes
OBJECTIVE: Within the realm of surgical education, there is a need for objective means to determine surgical competence and resident readiness to operate independently. We propose a novel, objective method of assessing resident confidence and clinical competence based on measurement of electrodermal activity (EDA) during live surgical procedures. We hypothesized that with progressive training, EDA responses to the stress of performing surgery would exhibit decline, elucidating an objective correlate of clinical competence...
March 31, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28369388/environmental-canalization-of-life-span-and-gene-expression-in-caenorhabditis-elegans
#20
Alexander Mendenhall, Matthew M Crane, Scott Leiser, George Sutphin, Patricia M Tedesco, Matt Kaeberlein, Thomas E Johnson, Roger Brent
Animals, particularly poikilotherms, exhibit distinct physiologies at different environmental temperatures. Here, we hypothesized that temperature-based differences in physiology could affect the amount of variation in complex quantitative traits. Specifically, we examined, in Caenorhabditis elegans, how different temperatures (15°C, 20°C, and 25°C) affected the amount of interindividual variation in life span and also expression of three reporter genes-transcriptional reporters for vit-2, gpd-2, and hsp-16...
February 22, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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