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https://www.readbyqxmd.com/read/29768372/technologies-for-participatory-medicine-and-health-promotion-in-the-elderly-population
#1
Laura Nieto-Riveiro, Betania Groba, M Carmen Miranda, Patricia Concheiro, Alejandro Pazos, Thais Pousada, Javier Pereira
INTRODUCTION: The progressive aging of the population is a socio-demographic phenomenon experienced by most countries in the world in recent decades, especially in Japan and in many European Union countries. During this process, so-called "geriatric syndromes" frequently occur. The focus of this study is the quality of life of the elderly in relation to these 3 factors: risk of falls, urinary incontinence, and insomnia. OBJECTIVE: The main purpose is to determine the impact of a multifactorial intervention program implemented with institutionalized elderly people...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29756417/dehydroepiandrosterone-and-erectile-function-a-review
#2
REVIEW
Ahmed I El-Sakka
To review the contemporary knowledge regarding the dehydroepiandrosterone and erectile function. Medline was reviewed for English-language journal articles spanning the time between January 1990 and December 2017, using the terms 'erectile function', 'dehydroepiandrosterone'. We used Journal Articles and review articles that found to be relevant to the purpose of this review. Criteria included all pertinent review articles, randomized controlled trials with tight methodological design, cohort studies and retrospective analyses...
May 11, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29745308/conservative-treatment-of-non-aneurysmal-infectious-aortitis-a-case-report-and-review-of-the-literature
#3
Jasper Callemeyn, Kim Daenens, Inge Derdelinckx, Steven Dymarkowski, Katleen Fagard
BACKGROUND:  Non-aneurysmal infectious aortitis is a rare clinical entity with most often lethal complications when surgical intervention is delayed. OBJECTIVES:  This report describes the case of a non-aneurysmal infectious aortitis complicated with a penetrating aortic ulcer in an elderly woman, caused by a methicillin-sensitive Staphylococcus aureus. Surgery was deemed contra-indicated and treatment was limited to the administration of intravenous vancomycin (2 grams daily), followed by flucloxacillin (6 times 2 grams daily)...
May 10, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29732540/retraction-sunlight-exposure-is-important-for-preventing-hip-fractures-in-patients-with-alzheimer-s-disease-parkinson-s-disease-or-stroke-by-j-iwamoto-t-takeda-and-h-matsumoto
#4
(no author information available yet)
The above article from Acta Neurologica Scandinavica, published online on 18 June 2011 in Wiley Online Library (http://wileyonlinelibrary.com) and in Volume 125, pp. 279-284, has been retracted by agreement between the authors, the Journal Editor-in-Chief Elinor Ben-Menachem and John Wiley & Sons Ltd. The Retraction has been agreed due to extensive duplication of previously published material on the part of Dr Sato, who has acknowledged full responsibility. Dr. Iwamoto would like to note the following information related to this retraction: Dr...
June 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29705760/quality-of-evidence-considered-by-health-canada-in-granting-full-market-authorisation-to-new-drugs-with-a-conditional-approval-a-retrospective-cohort-study
#5
Joel Lexchin
OBJECTIVES: This study examines the characteristics of studies that Health Canada uses to grant full marketing authorisation for products given a conditional approval between 1 January 1998 and 30 June 2017. DESIGN: Cohort study. DATA SOURCES: Journal articles listing drugs that fulfilled their conditions and received full marketing authorisation, Notice of Compliance database, Notice of Compliance with conditions website, Qualifying Notices listing required confirmatory studies, clinicaltrials...
April 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29680815/patient-trajectories-and-their-impact-on-mobility-social-participation-and-quality-of-life-in-patients-with-vertigo-dizziness-balance-disorders-and-osteoarthritis-mobile-tra-study-protocol-of-an-observational-practice-based-cohort-study
#6
Rebecca Kisch, Antje Bergmann, Daniela Koller, Reiner Leidl, Ulrich Mansmann, Martin Mueller, Linda Sanftenberg, Joerg Schelling, Leonie Sundmacher, Karen Voigt, Eva Grill
INTRODUCTION: Mobility limitations have a multitude of different negative consequences on elderly patients including decreasing opportunities for social participation, increasing the risk for morbidity and mortality. However, current healthcare has several shortcomings regarding mobility sustainment of older adults, namely a narrow focus on the underlying pathology, fragmentation of care across services and health professions and deficiencies in personalising care based on patients' needs and experiences...
April 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29680809/impact-of-dexmedetomidine-infusion-during-general-anaesthesia-on-incidence-of-postoperative-delirium-in-elderly-patients-after-major-non-cardiac-surgery-study-protocol-of-a-randomised-double-blinded-and-placebo-controlled-trial
#7
Bo-Jie Wang, Chun-Jing Li, Jian Hu, Huai-Jin Li, Chao Guo, Zhen-Han Wang, Qiao-Chu Zhang, Dong-Liang Mu, Dong-Xin Wang
INTRODUCTION: Delirium is a common complication in the elderly after surgery and is associated with worse outcomes. Multiple risk factors are related with postoperative delirium, such as exposure to general anaesthetics, pain and postoperative inflammatory response. Preclinical and clinical studies have shown that dexmedetomidine attenuated neurotoxicity induced by general anaesthetics, improved postoperative analgesia and inhibited inflammatory response after surgery. Several studies found that intraoperative use of dexmedetomidine can prevent postoperative delirium, but data were inconsistent...
April 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29677382/resident-to-resident-mistreatment-evaluation-of-a-staff-training-program-in-the-reduction-of-falls-and-injuries
#8
Jeanne A Teresi, Mildred Ramírez, Terry Fulmer, Julie Ellis, Stephanie Silver, Jian Kong, Joseph P Eimicke, Gabriel Boratgis, Rhoda Meador, Mark S Lachs, Karl Pillemer
Resident-to-resident elder mistreatment (R-REM) occurs frequently in long-term services and support settings. The purpose of the current study was to evaluate the effect of a R-REM training program for nursing and other frontline staff on resident falls and injuries in a cluster randomized trial of units within four nursing homes. Interview and observational data from a sample of 1,201 residents (n = 600 and n = 601 in the usual care and intervention groups, respectively) and staff were collected at baseline and 6 and 12 months...
April 19, 2018: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/29666141/examining-the-effectiveness-of-consuming-flour-made-from-agronomically-biofortified-wheat-zincol-2016-nr-421-for-improving-zn-status-in-women-in-a-low-resource-setting-in-pakistan-study-protocol-for-a-randomised-double-blind-controlled-cross-over-trial-bizifed
#9
Nicola M Lowe, Muhammad Jaffar Khan, Martin R Broadley, Munir H Zia, Harry J McArdle, Edward J M Joy, Heather Ohly, Babar Shahzad, Ubaid Ullah, Gul Kabana, Rashid Medhi, Mukhtiar Zaman Afridi
INTRODUCTION: Dietary zinc (Zn) deficiency is a global problem, particularly in low-income and middle-income countries where access to rich, animal-source foods of Zn is limited due to poverty. In Pakistan, Zn deficiency affects over 40% of the adult female population, resulting in suboptimal immune status and increased likelihood of complications during pregnancy. METHODS AND ANALYSIS: We are conducting a double-blind, randomised controlled feeding study with cross-over design in a low-resource setting in Pakistan...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29652246/metformin-in-non-diabetic-hyperglycaemia-the-glint-feasibility-rct
#10
Simon J Griffin, M Angelyn Bethel, Rury R Holman, Kamlesh Khunti, Nicholas Wareham, Gwen Brierley, Melanie Davies, Andrew Dymond, Rose Eichenberger, Philip Evans, Alastair Gray, Colin Greaves, Kyla Harrington, Graham Hitman, Greg Irving, Sarah Lessels, Ann Millward, John R Petrie, Martin Rutter, Mike Sampson, Naveed Sattar, Stephen Sharp
BACKGROUND: The treatment of people with diabetes with metformin can reduce cardiovascular disease (CVD) and may reduce the risk of cancer. However, it is unknown whether or not metformin can reduce the risk of these outcomes in people with elevated blood glucose levels below the threshold for diabetes [i.e. non-diabetic hyperglycaemia (NDH)]. OBJECTIVE: To assess the feasibility of the Glucose Lowering In Non-diabetic hyperglycaemia Trial (GLINT) and to estimate the key parameters to inform the design of the full trial...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29608544/treatment-optimization-for-hepatocellular-carcinoma-in-elderly-patients-in-a-japanese-nationwide-cohort
#11
Masaki Kaibori, Kengo Yoshii, Kiyoshi Hasegawa, Asao Ogawa, Shoji Kubo, Ryosuke Tateishi, Namiki Izumi, Masumi Kadoya, Masatoshi Kudo, Takashi Kumada, Michiie Sakamoto, Osamu Nakashima, Yutaka Matsuyama, Tadatoshi Takayama, Norihiro Kokudo
OBJECTIVE: We reviewed nationwide follow-up data to determine outcomes of different treatments for early-stage hepatocellular carcinoma (HCC) in elderly patients. SUMMARY BACKGROUND DATA: Outcomes of early-stage HCC treatments in elderly patients have not been prospectively compared. METHODS: We included 6490 HCC patients, aged ≥75 years at treatment, who underwent curative hepatic resection (HR, n = 2020), radiofrequency ablation (RFA, n = 1888), microwave ablation (MWA, n = 193), or transcatheter arterial chemoembolization (TACE, n = 2389), and compared their characteristics and survival...
March 30, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29596083/the-scope-of-extra-professional-caregiving-challenges-among-early-career-faculty-findings-from-a-university-medical-center
#12
Katherine E Hartmann, Alexandra C Sundermann, Rebecca Helton, Helen Bird, Ashley Wood
PURPOSE: Academic scientists work in competitive environments and many institutions invest in career development supports. These investments may be imperiled when extra-professional demands challenge a faculty member's reserve capacity. This research assessed prevalence of caregiving challenges and estimated incidence of stressful life events. METHOD: In 2015-2016, the authors surveyed recipients of career development awards supporting ≥ 75% effort and individuals within the funding period of their first National Institutes of Health R01 or equivalent at Vanderbilt University Medical Center...
March 27, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29564151/analysis-of-trends-and-prospects-regarding-stents-for-human-blood-vessels
#13
Jeong Hee Lee, Eung Do Kim, Eun Jung Jun, Hyoung Sun Yoo, Joon Woo Lee
Background: The purpose of this paper is to provide technology trends and information regarding market and prospects in stents used for human blood vessels in Korea and the world.A stent is a medical device in the form of a cylindrical metal net used to normalize flow when blood or other bodily fluids such as biliary fluids are obstructed in blood vessels, gastrointestinal tracts, etc. by inserting the stent into a narrowed or clogged area. Stents are classified into vascular and non-vascular stents...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29523104/prognostic-models-for-complete-recovery-in-ischemic-stroke-a-systematic-review-and-meta-analysis
#14
Nampet Jampathong, Malinee Laopaiboon, Siwanon Rattanakanokchai, Porjai Pattanittum
BACKGROUND: Prognostic models have been increasingly developed to predict complete recovery in ischemic stroke. However, questions arise about the performance characteristics of these models. The aim of this study was to systematically review and synthesize performance of existing prognostic models for complete recovery in ischemic stroke. METHODS: We searched journal publications indexed in PUBMED, SCOPUS, CENTRAL, ISI Web of Science and OVID MEDLINE from inception until 4 December, 2017, for studies designed to develop and/or validate prognostic models for predicting complete recovery in ischemic stroke patients...
March 9, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29506537/a-mini-review-of-quality-of-life-as-an-outcome-in-prostate-cancer-trials-patient-centered-approaches-are-needed-to-propose-appropriate-treatments-on-behalf-of-patients
#15
REVIEW
Yohann Foucher, Marine Lorent, Philippe Tessier, Stéphane Supiot, Véronique Sébille, Etienne Dantan
BACKGROUND: Patients with prostate cancer (PC) may be ready to make trade-offs between their quantity and their quality of life. For instance, elderly patients may prefer the absence of treatment if it is associated with a low-risk of disease progression, compared to treatments aiming at preventing disease progression but with a substantial deterioration of their Health-Related Quality of Life (HRQoL). Therefore, it seems relevant to compare the treatments by considering both survival and HRQoL...
March 5, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29505513/impact-of-inhalational-anesthetics-on-postoperative-cognitive-function-study-protocol-of-a-systematic-review-and-meta-analysis
#16
REVIEW
Yi-Qing Zou, Xiao-Bao Li, Zhi-Xing Yang, Jing-Min Zhou, Yi-Nan Wu, Zhi-Hu Zhao, Xiang-Zhu Liu, Chang-Li Hu
BACKGROUND: Conflict findings of the impact of inhalational anesthetics on postoperative cognitive function are reported. No systematic review has been performed to solve the problem. The aim of the study was to assess the effect of different inhalational anesthetics on postoperative cognitive function in a network meta-analysis. METHODS: We will search MEDLINE, EMBASE, the Central Register of Controlled Trials in the Cochrane library, and CINAHL for randomized controlled trials or cohort studies assessing the short-term or long-term cognitive function of elderly patients (over 60 years) receiving major surgeries and inhalational anesthetics (desflurane, isoflurane, sevoflurane, halothane, and nitrous oxide) during surgery...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29494421/phase-ii-clinical-trial-of-lenalidomide-and-dexamethasone-therapy-in-japanese-elderly-patients-with-newly-diagnosed-multiple-myeloma-to-determine-optimal-plasma-concentration-of-lenalidomide
#17
Takahiro Kobayashi, Masatomo Miura, Takenori Niioka, Maiko Abumiya, Fumiko Ito, Isuzu Kobayashi, Sho Ikeda, Tomoko Yoshioka, Yoshihiro Kameoka, Naoto Takahashi
BACKGROUND: The authors conducted a phase II clinical trial of lenalidomide and dexamethasone combination therapy in Japanese elderly patients with newly diagnosed multiple myeloma to evaluate its safety and efficacy and to determine whether safety and efficacy correlate with the plasma concentration of lenalidomide. METHODS: Forty patients received oral lenalidomide on days 1-21 of a 28-day cycle in addition to weekly doses of dexamethasone. Plasma concentrations of lenalidomide were measured, and the area under the concentration-time curve from 0 to 24 hours (AUC0-24) of lenalidomide was predicted using a formula the authors previously reported in this journal...
June 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29492097/active-aging-and-elderly-s-quality-of-life-comparing-the-impact-on-literature-of-projects-funded-by-the-european-union-and-usa
#18
REVIEW
I Kirilov, M Atzeni, A Perra, D Moro, M G Carta
Background: The objective of this research is to verify whether European projects on Active Aging (AA) and Elderly Quality of Life (Qol) funded by the Seventh Framework Programme (FP7) produce an impact on literature similar to projects funded by the National Health Institute (NHI) of the United States on international literature using well-known bibliometric indicators. This effort may be useful in developing standardized and replicable procedures. Methods: Fifteen randomly selected projects on AA and Elderly Qol concluded in August 2017 and funded by FP7 were compared to similar projects funded by the US NHI with reference to papers published (Scopus and Scholar), papers published in Q1 journals, and the number of citations of the papers linked to the projects...
2018: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/29487075/seeking-the-balance-between-caregiving-in-dementia-family-and-employment-study-protocol-for-a-mixed-methods-study-in-northern-germany
#19
Lydia Neubert, Hans-Helmut König, Christian Brettschneider
INTRODUCTION: The debate on reconciliation between childcare and working has to be expanded to caregiving for the elderly, since the importance of informal caregiving will increase in the future due to populations' ageing and women's increasing labour force participation. Informal caregivers who are caring for the rising number of persons with dementia (PwD) are often female and subjected to high caregiving requirements. These are added to further demands emerging from their family and work life...
February 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29485516/the-impact-of-advanced-age-on-the-outcomes-of-primary-total-hip-and-knee-arthroplasty-for-osteoarthritis-a-systematic-review
#20
Benjamin P d'S Murphy, Michelle M Dowsey, Peter F M Choong
BACKGROUND: Elective total hip arthroplasty (THA) and total knee arthroplasty (TKA) are effective options for the management of osteoarthritis that has not responded to conservative therapy, and they are increasing in utilization worldwide. Therefore, we sought to investigate how older age influences the outcomes of THA and TKA through a review of the current literature. METHODS: The Embase and MEDLINE databases were examined for relevant studies that assessed the role of older age in determining the outcomes of THA and TKA...
February 2018: JBJS Reviews
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