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Hu Yang, Gang Xu, Chun-Lan Huang, Ying Xia, Xiao-Wei Wang, Qiang Chen, Shou-Jie Wang, Li-Yun Zhang, Wei-Qiang Tan
Background: Liposuction-curettage (LC) is a popular and effective surgical method for the treatment of axillary bromhidrosis (AB). However, residual malodour and skin necrosis often appear after this type of surgery. We investigated the efficacy and complications of 4 methods of LC. Methods: A total of 280 patients with AB comprised the study cohort, of which 228 were followed up. We carried out 4 methods of modified tumescent LC through mini-incisions and provided a questionnaire for evaluation of surgical outcome...
November 2017: Plastic Surgery
Jin Ho Han, June-Kyu Kim, Kun Chul Yoon, Hyun Woo Shin
BACKGROUND: Osmidrosis is a malodorous disease caused by the breakdown of sweat secreted from the apocrine glands by surface bacteria. The aim of this study was to evaluate the effect of Versajet-assisted hydraulic epilation for the treatment of axillary osmidrosis. METHODS: Thirty-two patients with axillary osmidrosis (64 axillae) underwent Versajet-assisted hydraulic epilation between January 2016 and January 2017. Subjective assessments were evaluated by a patient survey at least 3 months after the procedure...
February 20, 2018: Aesthetic Plastic Surgery
Xiaogen Hu, Bo Chen, Dingquan Yang
BACKGROUND The study is to investigate the effectiveness and safety of the minimally invasive treatment for axillary osmidrosis by liposuction assisted circumferential trimming. METHODS It was a retrospective study. From July 2014 to July 2017, 79 patients underwent superficial liposuction and circumferential trimming for bilateral axillary osmidrosis. The preoperative and postoperative degree of axillary malodor was measured by doctors and the patients themselves. In the doctor's evaluation, the odor levels were scored by the sniffing method before and 1 year after treatment...
February 19, 2018: Journal of Dermatological Treatment
Ali Asilian, Masoom Shahbazi, Bahareh Abtahi-Naeini, Nazila Poostiyan, Mohammad Ali Nilforoushzadeh
BACKGROUND: Axillary osmidrosis is a common problem with a strong negative impact on the professional and social quality of life. Several options are available for its treatment. But there are no treatment guidelines. The objective of this study was to evaluate efficacy and safety of percutaneous ethanol injection for treatment of axillary osmidrosis. METHODS: A randomized, double-blind, placebo-controlled clinical trial to assess clinical efficacy and postoperative complications of percutaneous ethanol injection was performed among 60 patients (12-35 years of age) with axillary osmidrosis...
February 1, 2018: Indian Journal of Dermatology, Venereology and Leprology
Chun-Kai Chang, Chun-Yu Chen, Kuo-Feng Hsu, Han-Ting Chiu, Tzi-Shiang Chu, Hung-Hui Liu, Meng-Xun Goh, Shyi-Gen Chen
Axillary hyperhidrosis combined with osmidrosis is a common problem, especially in Asian communities, that patients find annoying. Even though several surgical techniques have been reported to treat hyperhidrosis/osmidrosis permanently, patients would prefer a non-surgical approach. A microwave-based device was invented during this decade, and it has proven to be a safe and efficient way to treat axillary hyperhidrosis/osmidrosis without major complications. Mild complications reported are vacuum-associated marks, oedema, tenderness and temporary altered skin sensation...
November 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Yunqing Ren, Wenting Liu, Jisu Chen, Jianyou Wang, Ke Wang, Jiong Zhou, Suiqing Cai, Min Zheng, Jianjun Liu, Lunfei Liu, Dan Xue
Axillary osmidrosis (AO) is a common condition characterized by an offensive odor arising from apocrine gland secretions in the axillae that socially and psychologically impairs affected individuals. The exact aetiology of AO is still not fully understood, but genetic factors have been suggested to play an important role. Recently, a single nucleotide polymorphism (SNP) rs17822931 in the ABCC11 gene located on human chromosome 16q12.1 has been shown to be associated with AO. In this study, we genotyped rs17822931 in two independent samples of Chinese Hans including 93 AO individuals vs 95 controls and 81 AO individuals vs 106 controls by using SNaPshot Multiplex Kit...
May 9, 2017: Scientific Reports
Yu Toyoda, Tappei Takada, Tsuneaki Gomi, Hiroshi Nakagawa, Toshihisa Ishikawa, Hiroshi Suzuki
Accumulating evidence suggests that the risk of axillary osmidrosis is governed by a non-synonymous single nucleotide polymorphism (SNP) 538G>A in human ATP-binding cassette C11 ( ABCC11 ) gene. However, little data are available for the expression of ABCC11 protein in human axillary apocrine glands that produce apocrine sweat-a source of odor from the armpits. To determine the effect of the non-synonymous SNP ABCC11 538G>A (G180R) on the ABCC11 in vivo, we generated transiently ABCC11-expressing transgenic mice with adenovirus vector, and examined the protein levels of each ABCC11 in the mice with immunoblotting using an anti-ABCC11 antibody we have generated in the present study...
February 15, 2017: International Journal of Molecular Sciences
Jin Yong Shin, Si-Gyun Roh, Nae-Ho Lee, Kyung-Moo Yang
Although osmidrosis has been widely discussed in respect to its treatment modalities, there has been no definite consideration of postoperative management after the treatment of osmidrosis. We have tested the 40-125 mmHg range of negative pressure. We present negative pressure wound therapy (NPWT) of 70 mmHg for postoperative management in osmidrosis because NPWT has a role in removing fluid, such as blood or seroma, and diminishing the dead space between the skin and subcutaneous tissue. Patients who receive NPWT have shown successful treatment outcomes and no skin necrosis or hematoma formation...
February 2017: Aesthetic Plastic Surgery
Jin Yong Shin, Si-Gyun Roh, Nae-Ho Lee, Kyung-Moo Yang
BACKGROUND: There are many treatment modalities associated with osmidrosis. The purpose of this study was to identify and compare effective osmidrosis treatments. METHODS: A systematic literature review and meta-analysis were performed using MEDLINE, EMBASE, and Cochrane databases. The osmidrosis treatment modalities were extracted as predictor variables, and recurrence and complications were extracted as outcome variables. Subgroup analysis was performed with regard to combined curettage, and fixed and random effect models were applied...
March 2017: Annals of Plastic Surgery
Yu Toyoda, Tappei Takada, Hiroshi Miyata, Toshihisa Ishikawa, Hiroshi Suzuki
ATP-binding cassette C11 (ABCC11) is a plasma membrane protein involved in the transport of a variety of lipophilic anions. ABCC11 wild-type is responsible for the high-secretion phenotypes in human apocrine glands, such as that of wet-type ear wax, and the risk of axillary osmidrosis. We have previously reported that mature ABCC11 is a glycoprotein containing two N-linked glycans at Asn838 and Asn844. However, little is known about the role of N-linked glycosylation in the regulation of ABCC11 protein. In the current study, we investigated the effects of N-linked glycosylation on the protein level and localization of ABCC11 using polarized Madin-Darby canine kidney II cells...
2016: PloS One
Yu Toyoda, Tsuneaki Gomi, Hiroshi Nakagawa, Makoto Nagakura, Toshihisa Ishikawa
The importance of personalized medicine and healthcare is becoming increasingly recognized. Genetic polymorphisms associated with potential risks of various human genetic diseases as well as drug-induced adverse reactions have recently been well studied, and their underlying molecular mechanisms are being uncovered by functional genomics as well as genome-wide association studies. Knowledge of certain genetic polymorphisms is clinically important for our understanding of interindividual differences in drug response and/or disease risk...
2016: BioMed Research International
Y-T Chen, P-Y Shih, H-J Chen, T-J Chen
BACKGROUND: Axillary osmidrosis can lead to personal and social problems, particularly in Asian culture. Superficial liposuction with curettage and subcutaneous laser are surgical intervention commonly used for osmidrosis. OBJECTIVE: Retrospectively, we compared the effectiveness and complications between superficial liposuction with curettage and subcutaneous laser in an Asian population. METHODS: Totally, 66 and 19 patients receiving subcutaneous laser and superficial liposuction with curettage (LC) were recruited...
October 2015: Journal of the European Academy of Dermatology and Venereology: JEADV
Kayoko Ishikawa, Hidekazu Fukamizu, Tetsuya Takiguchi, Yusuke Ohta, Yoshiki Tokura
PURPOSE: We investigated the effectiveness of a newly developed device for the delivery of local anesthetics in the treatment of axillary osmidrosis and hyperhidrosis. We developed a device with three fine, stainless steel needles fabricated with a bevel angle facing outside ("three-microneedle device" [TMD]) to release a drug broadly and homogeneously into tissue in the horizontal plane. Use of this device could reduce the risk of complications when transcutaneous injections are undertaken...
2015: Patient Preference and Adherence
Cui Wang, Huiling Wu, Feiya Du, Shujun Le, Shusen Zheng
BACKGROUND: Axillary osmidrosis results in social and psychological problems. Liposuction-assisted techniques used as treatments have been reported to have high recurrence rates. This study aims at introducing the aggressive suction-curettage technique in comparison to the open excision procedure. METHODS: From February 2009 to February 2014, 130 patients were randomly divided into two groups (experimental and control groups). The experimental group was treated with aggressive suction-curettage, while the control group was treated with an open excision...
August 2015: Aesthetic Plastic Surgery
Zhechen Zhu, Hongwei Zhang, Guanghua Luo, Ning Xu, Zhonglan Pan
It has been suggested that the adenosine triphosphate‑binding cassette sub‑family C member 11 (ABCC11) gene polymorphism and apolipoprotein D (ApoD), an odor precursor carrier, may be important in the formation of axillary odor. To date, few studies have examined the potential correlation between these two factors. The present study aimed to investigate the association between a 538 G>A single‑nucleotide polymorphism (SNP) of the ABCC11 gene and the mRNA expression levels of ApoD in the apocrine gland of patients with osmidrosis...
June 2015: Molecular Medicine Reports
Rongrong Wang, Jie Yang, Jiaming Sun
BACKGROUND: Though minimally invasive procedures often yield excellent esthetic results for axillary osmidrosis, the high recurrence rates of malodor limit its further application. Incomplete removal of the apocrine glands would lead to recurrence of the axillary bromhidrosis, while excessive resection of the apocrine glands firmly attached to the dermis would easily result in local skin necrosis. Therefore, accurate management of the apocrine glands is extraordinarily important, particularly with a limited access...
February 2015: Aesthetic Plastic Surgery
Sang Geun Lee, Hwa Jung Ryu, Il-Hwan Kim
Many treatment modalities have been developed for axillary osmidrosis. It is well known that the surgical treatment has the best results. However, there is a high possibility of side effects. The 1,444-nm lipolysis laser has been recently introduced to remove the apocrine glands. So far, subdermal coagulation treatment with a 1,444-nm Nd:YAG laser may be the least invasive and most effective therapy for axillary osmidrosis. However, according to our previous experience, the recurrence rate was 20%~30%. This emphasizes the need for combination of surgical method and non-surgical method and we combined subcutaneous tissue removal and photothermocoagulation with a 1,444-nm Nd:YAG laser...
December 2014: Annals of Dermatology
Jae H Jeong, Jin M Hong, Chang S Pak, Ji H Kim, Chan Y Heo
BACKGROUND: Lasers have been proposed as an alternative treatment for axillary osmidrosis. OBJECTIVE: This study aimed to investigate the use of a neodymium:yttrium-aluminum-garnet laser with a wavelength of 1,444 nm for treating axillary osmidrosis. MATERIALS AND METHODS: Eighteen patients with axillary osmidrosis who underwent an operation with a 1,444-nm wavelength laser were included in this study. Operative parameters were as follows: pulse = 40 Hz and energy = 170 mJ...
August 2014: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Hun-Gon Kim
BACKGROUND: Axillary osmidrosis causes unpleasant odors and profuse sweating, resulting in social and psychological problems. Many treatment modalities have been attempted and liposuction is preferred because of the minimal scar, although the problem of a high recurrence rate still exists. The aim of this study was to introduce and evaluate the efficacy of a new technique to treat axillary osmidrosis using a liposuction machine. METHODS: From January 2002 to December 2012, a total of 4,322 patients with axillary osmidrosis were treated with a new technique that combines suction with aggressive scraping...
April 2014: Aesthetic Plastic Surgery
Fei Han, Qing Li
OBJECTIVE: To compare the therapeutic effect of traditional and modified apocrine gland removal surgery with the combination of high radiofrequency knife for axillary osmidrosis. METHODS: 105 cases (210 sides) were randomly divided into traditional group A (38 cases, 76 sides) and modified group B (67 cases, 134 sides). The wound healing and complications were recorded. The clinical effect was followed up for 6-12 months after operation. RESULTS: No flap necrosis happened in both groups...
September 2013: Zhonghua Zheng Xing Wai Ke za Zhi, Zhonghua Zhengxing Waike Zazhi, Chinese Journal of Plastic Surgery
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