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Yu Toyoda, Tappei Takada, Tsuneaki Gomi, Hiroshi Nakagawa, Toshihisa Ishikawa, Hiroshi Suzuki
Accumulating evidence suggests that the risk of axillary osmidrosis is governed by a non-synonymous single nucleotide polymorphism (SNP) 538G>A in human ATP-binding cassette C11 (ABCC11) gene. However, little data are available for the expression of ABCC11 protein in human axillary apocrine glands that produce apocrine sweat-a source of odor from the armpits. To determine the effect of the non-synonymous SNP ABCC11 538G>A (G180R) on the ABCC11 in vivo, we generated transiently ABCC11-expressing transgenic mice with adenovirus vector, and examined the protein levels of each ABCC11 in the mice with immunoblotting using an anti-ABCC11 antibody we have generated in the present study...
February 15, 2017: International Journal of Molecular Sciences
Jin Yong Shin, Si-Gyun Roh, Nae-Ho Lee, Kyung-Moo Yang
Although osmidrosis has been widely discussed in respect to its treatment modalities, there has been no definite consideration of postoperative management after the treatment of osmidrosis. We have tested the 40-125 mmHg range of negative pressure. We present negative pressure wound therapy (NPWT) of 70 mmHg for postoperative management in osmidrosis because NPWT has a role in removing fluid, such as blood or seroma, and diminishing the dead space between the skin and subcutaneous tissue. Patients who receive NPWT have shown successful treatment outcomes and no skin necrosis or hematoma formation...
December 28, 2016: Aesthetic Plastic Surgery
Jin Yong Shin, Si-Gyun Roh, Nae-Ho Lee, Kyung-Moo Yang
BACKGROUND: There are many treatment modalities associated with osmidrosis. The purpose of this study was to identify and compare effective osmidrosis treatments. METHODS: A systematic literature review and meta-analysis were performed using MEDLINE, EMBASE, and Cochrane databases. The osmidrosis treatment modalities were extracted as predictor variables, and recurrence and complications were extracted as outcome variables. Subgroup analysis was performed with regard to combined curettage, and fixed and random effect models were applied...
March 2017: Annals of Plastic Surgery
Yu Toyoda, Tappei Takada, Hiroshi Miyata, Toshihisa Ishikawa, Hiroshi Suzuki
ATP-binding cassette C11 (ABCC11) is a plasma membrane protein involved in the transport of a variety of lipophilic anions. ABCC11 wild-type is responsible for the high-secretion phenotypes in human apocrine glands, such as that of wet-type ear wax, and the risk of axillary osmidrosis. We have previously reported that mature ABCC11 is a glycoprotein containing two N-linked glycans at Asn838 and Asn844. However, little is known about the role of N-linked glycosylation in the regulation of ABCC11 protein. In the current study, we investigated the effects of N-linked glycosylation on the protein level and localization of ABCC11 using polarized Madin-Darby canine kidney II cells...
2016: PloS One
Yu Toyoda, Tsuneaki Gomi, Hiroshi Nakagawa, Makoto Nagakura, Toshihisa Ishikawa
The importance of personalized medicine and healthcare is becoming increasingly recognized. Genetic polymorphisms associated with potential risks of various human genetic diseases as well as drug-induced adverse reactions have recently been well studied, and their underlying molecular mechanisms are being uncovered by functional genomics as well as genome-wide association studies. Knowledge of certain genetic polymorphisms is clinically important for our understanding of interindividual differences in drug response and/or disease risk...
2016: BioMed Research International
Y-T Chen, P-Y Shih, H-J Chen, T-J Chen
BACKGROUND: Axillary osmidrosis can lead to personal and social problems, particularly in Asian culture. Superficial liposuction with curettage and subcutaneous laser are surgical intervention commonly used for osmidrosis. OBJECTIVE: Retrospectively, we compared the effectiveness and complications between superficial liposuction with curettage and subcutaneous laser in an Asian population. METHODS: Totally, 66 and 19 patients receiving subcutaneous laser and superficial liposuction with curettage (LC) were recruited...
October 2015: Journal of the European Academy of Dermatology and Venereology: JEADV
Kayoko Ishikawa, Hidekazu Fukamizu, Tetsuya Takiguchi, Yusuke Ohta, Yoshiki Tokura
PURPOSE: We investigated the effectiveness of a newly developed device for the delivery of local anesthetics in the treatment of axillary osmidrosis and hyperhidrosis. We developed a device with three fine, stainless steel needles fabricated with a bevel angle facing outside ("three-microneedle device" [TMD]) to release a drug broadly and homogeneously into tissue in the horizontal plane. Use of this device could reduce the risk of complications when transcutaneous injections are undertaken...
2015: Patient Preference and Adherence
Cui Wang, Huiling Wu, Feiya Du, Shujun Le, Shusen Zheng
BACKGROUND: Axillary osmidrosis results in social and psychological problems. Liposuction-assisted techniques used as treatments have been reported to have high recurrence rates. This study aims at introducing the aggressive suction-curettage technique in comparison to the open excision procedure. METHODS: From February 2009 to February 2014, 130 patients were randomly divided into two groups (experimental and control groups). The experimental group was treated with aggressive suction-curettage, while the control group was treated with an open excision...
August 2015: Aesthetic Plastic Surgery
Zhechen Zhu, Hongwei Zhang, Guanghua Luo, Ning Xu, Zhonglan Pan
It has been suggested that the adenosine triphosphate‑binding cassette sub‑family C member 11 (ABCC11) gene polymorphism and apolipoprotein D (ApoD), an odor precursor carrier, may be important in the formation of axillary odor. To date, few studies have examined the potential correlation between these two factors. The present study aimed to investigate the association between a 538 G>A single‑nucleotide polymorphism (SNP) of the ABCC11 gene and the mRNA expression levels of ApoD in the apocrine gland of patients with osmidrosis...
June 2015: Molecular Medicine Reports
Rongrong Wang, Jie Yang, Jiaming Sun
BACKGROUND: Though minimally invasive procedures often yield excellent esthetic results for axillary osmidrosis, the high recurrence rates of malodor limit its further application. Incomplete removal of the apocrine glands would lead to recurrence of the axillary bromhidrosis, while excessive resection of the apocrine glands firmly attached to the dermis would easily result in local skin necrosis. Therefore, accurate management of the apocrine glands is extraordinarily important, particularly with a limited access...
February 2015: Aesthetic Plastic Surgery
Sang Geun Lee, Hwa Jung Ryu, Il-Hwan Kim
Many treatment modalities have been developed for axillary osmidrosis. It is well known that the surgical treatment has the best results. However, there is a high possibility of side effects. The 1,444-nm lipolysis laser has been recently introduced to remove the apocrine glands. So far, subdermal coagulation treatment with a 1,444-nm Nd:YAG laser may be the least invasive and most effective therapy for axillary osmidrosis. However, according to our previous experience, the recurrence rate was 20%~30%. This emphasizes the need for combination of surgical method and non-surgical method and we combined subcutaneous tissue removal and photothermocoagulation with a 1,444-nm Nd:YAG laser...
December 2014: Annals of Dermatology
Jae H Jeong, Jin M Hong, Chang S Pak, Ji H Kim, Chan Y Heo
BACKGROUND: Lasers have been proposed as an alternative treatment for axillary osmidrosis. OBJECTIVE: This study aimed to investigate the use of a neodymium:yttrium-aluminum-garnet laser with a wavelength of 1,444 nm for treating axillary osmidrosis. MATERIALS AND METHODS: Eighteen patients with axillary osmidrosis who underwent an operation with a 1,444-nm wavelength laser were included in this study. Operative parameters were as follows: pulse = 40 Hz and energy = 170 mJ...
August 2014: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Hun-Gon Kim
BACKGROUND: Axillary osmidrosis causes unpleasant odors and profuse sweating, resulting in social and psychological problems. Many treatment modalities have been attempted and liposuction is preferred because of the minimal scar, although the problem of a high recurrence rate still exists. The aim of this study was to introduce and evaluate the efficacy of a new technique to treat axillary osmidrosis using a liposuction machine. METHODS: From January 2002 to December 2012, a total of 4,322 patients with axillary osmidrosis were treated with a new technique that combines suction with aggressive scraping...
April 2014: Aesthetic Plastic Surgery
Fei Han, Qing Li
OBJECTIVE: To compare the therapeutic effect of traditional and modified apocrine gland removal surgery with the combination of high radiofrequency knife for axillary osmidrosis. METHODS: 105 cases (210 sides) were randomly divided into traditional group A (38 cases, 76 sides) and modified group B (67 cases, 134 sides). The wound healing and complications were recorded. The clinical effect was followed up for 6-12 months after operation. RESULTS: No flap necrosis happened in both groups...
September 2013: Zhonghua Zheng Xing Wai Ke za Zhi, Zhonghua Zhengxing Waike Zazhi, Chinese Journal of Plastic Surgery
Aiguo Xie, Lanjun Nie, Qian Tan
The objective of this study was to investigate the efficacy of local injection of botulinum toxin A for treating axillary osmidrosis. One hundred and fifty patients with axillary osmidrosis were randomly divided to receive botulinum toxin A injection treatment (50 U of botulinum toxin A was injected intracutaneously into 6-20 different sites within each axilla, n = 74) or surgical excision of the apocrine glands (n = 76). The patients were followed up for 1-3 months to analyze the therapeutic effect and complications of the two methods...
February 2014: Journal of Dermatology
Yang Sun, Jianhong Long, Yongjie Wang
OBJECTIVE: To explore the relationship between ABCC11 gene single nucleotide polymorphism (SNP) and the incidence of axillary osmidrosis in Chinese Han population. METHODS: The genotype of ABCC11 gene SNP at rs17822931 in 40 patients with axillary osmidrosis and 5 normal Han people was detected and analyzed by high resolution melt and gene sequencing. RESULTS: The detection of the genotype of ABCC11 gene SNP at rs17822931 showed that: 37 of the 40 patients were GA genotype and the other 3 were GG genotype, while the 5 normal subjects were AA genotype...
November 2013: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Hui Chen, Guodong Yang, Yingli Li, Xiaoli Li, Jie Du
OBJECTIVE: To investigate the expression of apolipoprotein D (ApoD) and androgen receptor (AR), two proteins related to E-3M2H secretion, in the apocrine sweat gland of patients with axillary osmidrosis (AO) and healthy subjects, and to explore the cause of abnormal ApoD expression in these patients. METHODS: Samples were collected from healthy controls (n=4) and AO patients (n=10). Immunohistochemistry, real-time PCR and western blot assay were performed to measure the mRNA and protein expression of ApoD and AR...
2013: International Journal of Clinical and Experimental Medicine
Hyung-Sup Shim, Sung-Kee Min, Jin-Soo Lim, Ki-Taik Han, Min-Cheol Kim
BACKGROUND: Axillary osmidrosis is characterized by unpleasant odors originating from the axillary apocrine glands, resulting in psychosocial stress. The main treatment modality is apocrine gland removal. Until now, of the various surgical techniques have sometimes caused serious complications. We describe herein the favorable outcomes of a new method for ablating apocrine glands by minimal subdermal shaving using sclerotherapy with absolute ethanol. METHODS: A total of 12 patients underwent the procedure...
July 2013: Archives of Plastic Surgery
Zhi Ding, Jianghong Zheng
BACKGROUND: Axillary osmidrosis is a distressing condition caused by excessive secretion by the apocrine glands. Surgical ablation of the subcutis without skin excision is the most popular solution for axillary osmidrosis. Various special operating instruments have been employed to help remove the subcutis. However, ideal results are not always achieved. This study aimed to present our experience of treating osmidrosis by two different sub-dermal trimming techniques and compare two techniques...
November 2013: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
X Han, F Li
BACKGROUND: The development of body odour, especially in the armpits, a condition known as axillary osmidrosis, is a common condition that is annoying to patients and can cause them considerable social embarrassment. Ablation of the apocrine glands is the mainstay of treatment, and various methods have been used to achieve this; however, most involve some form of surgery or invasive treatment, and can result in complications. AIM: To evaluate the effectiveness and complications of percutaneous ethanol injection (PEI) for the treatment of axillary osmidrosis...
July 2013: Clinical and Experimental Dermatology
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