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https://www.readbyqxmd.com/read/29066862/localized-neuropathic-pain-an-expert-consensus-on-local-treatments
#1
REVIEW
Gisèle Pickering, Elodie Martin, Florence Tiberghien, Claire Delorme, Gérard Mick
BACKGROUND: Pain localization is one of the hallmarks for the choice of first-line treatment in neuropathic pain. This literature review has been conducted to provide an overview of the current knowledge regarding the etiology and pathophysiology of localized neuropathic pain (LNP), its assessment and the existing topical pharmacological treatments. MATERIALS AND METHODS: Literature review was performed using Medline from 2010 to December 2016, and all studies involving LNP and treatments were examined...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29025285/safety-and-efficacy-of-canagliflozin-in-elderly-patients-with-type-2-diabetes-mellitus-a-1-year-post-marketing-surveillance-in-japan
#2
Maki Goda, Tomoko Yamakura, Kazuyo Sasaki, Takumi Tajima, Makoto Ueno
Objective To evaluate the safety and efficacy of canagliflozin in elderly patients with type 2 diabetes mellitus (T2DM) in clinical settings. Methods We conducted a 1-year post-marketing surveillance (PMS) of canagliflozin in almost all the elderly patients (≥65 years old) with T2DM who began taking canagliflozin during the first 3 months after its launch in Japan. The main outcomes included the incidences of adverse drug reactions (ADRs), serious ADRs and the changes of laboratory tests as well as efficacy variables...
October 13, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28944983/oral-prolonged-release-oxycodone-naloxone-for-managing-pain-and-opioid-induced-constipation-a-review-of-the-evidence
#3
REVIEW
Bart J Morlion, Stefan A Mueller-Lissner, Renato Vellucci, Wojciech Leppert, Benoît C Coffin, Sara L Dickerson, Tony O'Brien
BACKGROUND: Opioids provide effective relief from moderate-to-severe pain and should be prescribed as part of a multifaceted approach to pain management when other treatments have failed. Fixed-dose oxycodone/naloxone prolonged-release tablets (OXN PR) were designed to address the opioid class effect of opioid-induced constipation (OIC) by combining the analgesic efficacy of oxycodone with the opioid receptor antagonist, naloxone, which has negligible systemic availability when administered orally...
September 25, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28934715/stercoral-perforation-of-the-rectosigmoid-colon-due-to-chronic-constipation-a-case-report
#4
Mustafa Fevzi Celayir, Hakan Mustafa Köksal, Mehmet Uludag
INTRODUCTION: Chronic constipation is very common in elderly patients. As a result of this situation fecaloma is also frequently seen at these ages. However, the stercoral perforation caused by fecaloma is a rare situation to occur. The rectosigmoid colon is the most affected colonic segment. It is seen in older patients with concomitant diseases and a low quality of life. PRESENTATION OF CASE: Here in this case, we have to report an 83 - year-old male patient who came to the emergency room with complaints of abdominal pain and constipation for two days...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28801825/intractable-constipation-in-the-elderly
#5
REVIEW
Noemi Baffy, Amy E Foxx-Orenstein, Lucinda A Harris, Susan Sterler
Chronic constipation is a common gastrointestinal disorder disproportionately affecting the elderly. Immobility, polypharmacy, and physiologic changes contribute to its increased prevalence in this population. Unidentified and undertreated constipation leads to a significant negative impact on quality of life and an increase in healthcare spending. Careful physical examination and exploration of the clinical history can unmask primary and secondary forms of constipation, guiding diagnostic and therapeutic considerations...
September 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28756376/obturator-hernia-a-rare-cause-of-bowel-obstruction
#6
Cã Tia Carreira Rito, Josà Travassos, Joana Patrà Cio, Ana Luisa Duarte
An obturator hernia is a rare condition and an unusual cause of intestinal obstruction. With a challenging diagnosis, it has one of the highest mortality rates of all abdominal wall hernias. The authors present a case of an elderly woman with bowel obstruction secondary to an incarcerated obturator hernia. An 80-year-old woman presented at the emergency room with complaints for the last 2 days of nausea, vomiting, constipation and lower right abdominal pain that radiated down to the right medial thigh. Abdominal tenderness to deep palpation of the right iliac fossa and mildly distention were noted...
July 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28737064/the-effects-of-delirium-prevention-guidelines-on-elderly-stroke-patients
#7
Jihye Song, Minkyung Lee, Dukyoo Jung
This study aimed to evaluate the effectiveness of the delirium prevention interventions recommended by the Delirium Prevention Guidelines for Elderly Stroke Patients (DPGESP). The DPGESP comprises nine dimensions with 28 interventions, including risk factor assessment, orientation disorder prevention, sleeping pattern maintenance, sensory interventions, constipation, dehydration, hypoxia and infection prevention, pain management, and appropriate nutrition maintenance. This quasi-experimental study used a nonequivalent control group and a pretest-posttest design...
July 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/28660594/thalidomide-combined-with-chemotherapy-in-treating-elderly-patients-with-advanced-gastric-cancer
#8
Ya Li, Yanjun Chu, Ruifeng Song, Feng Xu
AIM: The current systemic chemotherapy brings toxicity to human body, which elder patients suffer more than young people. The effective and well-tolerated treatment methods are of great importance for elderly advanced GC patients. This paper proposed an effective way of combining thalidomide with chemotherapy to treat elderly advanced GC patients, on the purpose of improving life quality and the treatment efficacy. METHODS: In the control group, capecitabine was given with 2000 mg/m(2) daily in a manner of 2 weeks on and 1 week off for elderly advanced GC patients...
June 28, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28658792/serous-microcystic-adenoma-of-pancreas-a-case-series-from-a-tertiary-care-centre-in-southern-india
#9
K Rajasree Varma, Saji Francis, P P Sathi, C Saikiran Reddy
Serous microcystic adenoma is a rare exocrine tumour of the cystic neoplasm of pancreas seen predominantly in the elderly population. The first patient was a 56-year-old diabetic woman with abdominal pain, constipation and loss of weight since two months. The second patient was a 73-year-old female with complaints of abdominal pain and back pain since one year. The third patient was a 72-year-old diabetic man with complaints of burning sensation in the right lumbar region since two months. Clinical and laboratory examinations were normal...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28639056/relevance-of-the-clinical-and-psychophysiological-variables-in-the-dyssynergic-defecation-a-comparative-study-in-elderly-subjects
#10
Miguel A Simón, Ana M Bueno
The relevance of several clinical and psychophysiological variables in the dyssynergic defecation in elderly subjects was investigated in this study. To accomplish this, 30 elderly subjects (10 without anorectal disorders, 10 with chronic constipation and 10 with dyssynergic defecation) were repeatedly assessed once per week for 4 weeks, with the following measures being collected at each session: EMG-activity (µV) of the external anal sphincter (at rest, during squeezing, and during straining to defecate), stool frequency, difficulty defecation level, pain grade during defecation, and satisfaction level after evacuation...
June 21, 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/28575811/perforation-of-the-cecum-resulting-from-a-closed-loop-obstruction-in-a-patient-with-an-adenocarcinoma-of-the-sigmoid-colon-a-case-report
#11
Jefferson Sing Toledo, Marley Moreira Correia, Rafael Rodrigues Coutinho, Eduardo Fukamachi Kifer, Diego de Faria Magalhães Torres
INTRODUCTION: Bowel obstruction is one of the principal non-traumatic causes of general surgery emergencies, both in Brazil and worldwide. This condition can be classified according to the degree (complete or incomplete), clinical course (acute or chronic) or nature (mechanical, vascular or functional) of the obstruction. CASE REPORT: ESS, a 62-year old Brazilian woman from Rio de Janeiro, was admitted to the emergency department complaining of constipation of two weeks' duration...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28562581/prevalence-and-risk-factors-of-chronic-constipation-among-women-aged-50-years-and-older-in-shanghai-china
#12
Ling Huang, Huihong Jiang, Maoling Zhu, Baocai Wang, Minsi Tong, Huaguang Li, Mou-Bin Lin, Li Li
BACKGROUND Chronic constipation (CC) is a major public health problem worldwide, especially in elderly women. This study aimed to investigate the prevalence and risk factors of CC among women aged 50 years and older in Shanghai, China. MATERIAL AND METHODS A cross-sectional survey was conducted on 1950 women aged 50 years and older, randomly sampled in Yangpu District of Shanghai from April to October 2015. Information on demographic characteristics, lifestyle habits, medical history, and defecation situation was collected through in-person interviews...
May 31, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28562551/final-diagnoses-and-probability-of-new-reason-for-encounter-at-an-urban-clinic-in-japan-a-4-year-observational-study
#13
Motoharu Fukushi, Yukishige Ishibashi, Naoki Nago
Past clinical data are not currently used to calculate pretest probabilities, as they have not been put into a database in clinical settings. This observational study was designed to determine the initial reasons for utilizing home visits or visits to an outpatient urban clinic in Japan.All family medical clinic outpatients and patients visited by the clinic (total = 11,688) over 1460 days were enrolled.We used a Bayes theorem-based clinical decision support system to analyze codes for initial reason-for-encounter (examination and final diagnosis: pretest probability) and final diagnosis of patients with fever (conditional pretest probability)...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28508966/recurrent-purple-urine-bag-syndrome-presenting-with-full-spectrum-of-disease-severity-case-report-and-review-of-literature
#14
Junzhi Lin, Martha Hlafka, Omar Vargas, Mukul Bhattarai
Purple urine bag syndrome (PUBS) is a unique phenomenon characterized by purple discoloration of the urinary catheter bag and tubing following urinary catheterization lasting for hours to days. The purple discoloration is a mixture of indirubin dissolved in plastic with indigo on its surface. PUBS is most commonly associated with urinary tract infection (UTI) caused by bacteria with indoxyl phosphatase/sulfatase activity. It occurs predominantly in chronically catheterized, constipated elderly female patients...
November 2016: CEN Case Reports
https://www.readbyqxmd.com/read/28479877/laparoscopic-uterovaginal-prolapse-surgery-in-the-elderly-feasibility-and-outcomes
#15
Samuel W King, Helen Jefferis, Simon Jackson, Alexander G Marfin, Natalia Price
BACKGROUND: Uterovaginal prolapse in very elderly women is a growing problem due to increased life expectancy. Surgeons and anaesthetists may be wary of performing quality of life surgery on this higher risk group. Where surgery is undertaken, it is commonly performed vaginally; there is a perception that this is better tolerated than abdominal surgery. Little data is published about laparoscopic prolapse surgery tolerability in this population, and laparoscopic surgery is perceived within the urogynaecological community as complex and lengthy and hence inherently unsuitable for the very elderly...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/28467916/the-effect-of-probiotics-as-a-treatment-for-constipation-in-elderly-people-a-systematic-review
#16
REVIEW
Maria Isabel Martínez-Martínez, Raquel Calabuig-Tolsá, Omar Cauli
PURPOSE: Treating constipation in elderly people remains a challenge; the administration of probiotics may be a valid therapy for this problem as an alternative to traditional drug-based treatments. The objective of this systematic review was to evaluate the efficiency of probiotics in treating constipation in elderly people. METHODS: Articles related to this topic and published, without any time limitations, in the Medline, Embase, Scopus, Lilacs, or Cochrane databases were systematically reviewed according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines...
July 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28460206/supergiant-fecaloma-as-manifestation-of-chronic-constipation
#17
G Currò, C Lazzara, S Latteri, M Bartolotta, G Navarra
Fecaloma is common in patients with damage to the autonomic nervous system in the large bowel associated with Chagas disease (inflammatory and neoplastic) or Hirschprung's disease, in psychiatric patients and, more commonly, in elderly patients suffering with chronic constipation. Symptoms of fecaloma are usually nonspecific. Clinical examination can give the appearance of an abdominal tumor. Most cases of fecaloma are treated conservatively with digital evacuation and enemas. In severe and unremitting cases, surgery is required to prevent significant complications...
January 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28387681/prevalence-of-prodromal-parkinson-s-disease-as-defined-by-mds-research-criteria-among-elderly-patients-undergoing-colonoscopy
#18
Skorvanek Matej, Ladomirjakova Zuzana, Han Vladimir, Lesko Norbert, Feketeova Eva, Jarcuskova Dominika, Repkova Barbora, Spisak Peter, Urbancikova Zuzana, Vargova Adriana, Gombosova Laura, Zakuciova Maria, Veseliny Eduard, Trebuna Frantisek, Mechirova Eva, Gdovinova Zuzana
BACKGROUND: Gastrointestinal symptoms are a well-recognized and common premotor feature of Parkinson's disease (PD). Moreover, multiple studies have assessed the value of colonic α-synuclein as a potential marker of prodromal PD. Recently, the International Parkinson and Movement Disorders Society (MDS) defined research criteria for prodromal PD. OBJECTIVE: The aim of our study was to test the MDS research criteria in patients undergoing diagnostic colonoscopies as potential candidates for inclusion in prospective trials evaluating colonic biopsies as a potential biomarker of prodromal PD...
April 4, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28346570/tolerance-and-long-term-efficacy-of-polyethylene-glycol-4000-forlax%C3%A2-compared-to-lactulose-in-elderly-patients-with-chronic-constipation
#19
MULTICENTER STUDY
P Chassagne, P Ducrotte, P Garnier, H Mathiex-Fortunet
OBJECTIVES: To assess the tolerance and potential nutritional consequences of long-term repeated doses of PEG 4000 (10 to 30 g/day) in elderly patients with chronic constipation as compared to lactulose (10-30 g/day). DESIGN: Single blind, randomised, multicentre, parallel group comparative study. SETTING: Community-dwelling patients and nursing homes residents aged 70 years and older with a history of chronic constipation. Treatment intervention: PEG 4000 (10-30 g/day) or lactulose (10-30 g/day) for six months...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28284822/-algorithms-and-urinary-incontinence-in-the-elderly-assessment-treatment-recommendations-and-levels-of-evidence-review
#20
P Meyer
OBJECTIVES: Search processing algorithms in a primary care setting, analyzing the specifics of care management for seniors suffering from urinary incontinence (UI), described the recommendations and levels of evidence of treatment. METHODS: A literature review carried out via PubMed(®) and websites of scientific societies with search keywords classified according to an algorithm. RESULTS: One hundred algorithms have been discovered in the field of evaluation and treatment of UI...
March 2017: Progrès en Urologie
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