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neuropsychiatric manifestation of hyperthyroid

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https://www.readbyqxmd.com/read/26525086/iatrogenic-myxoedema-madness-following-radioactive-iodine-ablation-for-graves-disease-with-a-concurrent-diagnosis-of-primary-hyperaldosteronism
#1
V Larouche, L Snell, D V Morris
UNLABELLED: Myxoedema madness was first described as a consequence of severe hypothyroidism in 1949. Most cases were secondary to long-standing untreated primary hypothyroidism. We present the first reported case of iatrogenic myxoedema madness following radioactive iodine ablation for Graves' disease, with a second concurrent diagnosis of primary hyperaldosteronism. A 29-year-old woman presented with severe hypothyroidism, a 1-week history of psychotic behaviour and paranoid delusions 3 months after treatment with radioactive iodine ablation for Graves' disease...
2015: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/25903201/acute-psychosis-in-a-pregnant-patient-with-graves-hyperthyroidism-and-anti-nmda-receptor-encephalitis
#2
Jesslyn Lu, Susan Samson, Joseph Kass, Nalini Ram
A previously healthy 36-year-old woman presented with visual hallucinations and acute psychosis manifested predominantly as hypersexuality. Laboratory testing demonstrated elevated free thyroxine levels, suppressed thyroid-stimulating hormone levels and presence of thyroid-stimulating immunoglobulin and thyroid peroxidase (TPO) antibodies consistent with Graves' disease. Despite achieving biochemical euthyroidism, she remained profoundly hypersexual. She did not respond to additional treatment with antipsychotics and corticosteroids, prompting further evaluation...
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/24665922/genetic-disorders-of-thyroid-metabolism-and-brain-development
#3
REVIEW
Manju A Kurian, Heinz Jungbluth
Normal thyroid metabolism is essential for human development, including the formation and functioning of the central and peripheral nervous system. Disorders of thyroid metabolism are increasingly recognized within the spectrum of paediatric neurological disorders. Both hypothyroid and hyperthyroid disease states (resulting from genetic and acquired aetiologies) can lead to characteristic neurological syndromes, with cognitive delay, extrapyramidal movement disorders, neuropsychiatric symptoms, and neuromuscular manifestations...
July 2014: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/24011880/neuropsychiatric-manifestations-of-thyroid-disease
#4
REVIEW
Anna Z Feldman, Rupendra T Shrestha, James V Hennessey
The interface between thyroid hormone action and neuropsychiatric function is intricate, and several mechanisms of thyroid hormone uptake into brain tissues, hormone activation, and influences on neurotransmitter generation have been identified. Symptoms of hypothyroidism are nonspecific, whereas those attributed to thyrotoxicosis may be more characteristic. Neuropsychiatric manifestations triggered by thyroid dysfunction likely respond well to reestablishment of the euthyroid state, although some patients have persistent complaints...
September 2013: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/23203464/hyperthyreo%C3%A3-die-bij-ouderen-aspecifieke-symptomen-kunnen-leiden-tot-uitstel-van-de-diagnose-klinische-les
#5
F P Rozendaal
Thyreotoxicosis in the elderly: aspecific signs may cause a delay in diagnosis.The clinical manifestations of thyroid diseases in the elderly are often atypical and can easily be attributed to other medical conditions or 'normal aging'.Two nursing home patiënts with hyperthyroidism are described. Due to the atypical presentation of the thyroid disease their complaints were attributed to other conditions. In both patients there was a significant delay in diagnosis and treatment of hyperthyroidism.In elder patiens signs and symptoms of thyreotoxicosis are frequently related to cardiovascular, gastrointestinal and neuropsychiatric disorders...
April 2005: Tijdschrift Voor Gerontologie en Geriatrie
https://www.readbyqxmd.com/read/19810987/neurobehavioral-and-psychological-changes-induced-by-hyperthyroidism-diagnostic-and-therapeutic-implications
#6
Carlos E Fardella, Sergio Gloger
Clinical studies have demonstrated that neuropsychiatric symptoms may be common and often the only symptoms of patients affected by hyperthyroidism. The correct diagnosis of hyperthyroidism is crucial for optimal treatment because the neuropsychiatric symptoms tend to parallel resolution as the biochemical parameters of hyperthyroidism are normalized. For these reasons, a routine evaluation in every patient consulting for emotional pathologies is recommended, independent of other manifestations of thyroid disease...
September 2002: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/19548868/thyroid-hormone-antagonists-potential-medical-applications-and-structure-activity-relationships
#7
REVIEW
Johan Malm, Mathias Färnegârdh, Gary J Grover, Paul W Ladenson
Thyroid hormone receptors (TRs) exert profound effects on development, metabolism, and multiple specific organ functions. Principally by regulating crucial genes in a variety of tissues, the thyroid hormones, 3,5,3'-triiodo-L-thyronine (L-T(3), 1) and 3,5,3',5'-tetraiodo-L-thyronine (L-T(4), 2), influence basal calorigenesis and oxygen consumption, cardiac rate and contractility, lipid metabolism, bone structure and strength, and central nervous system functions critical for normal mentation and mood. Elevated levels of circulating and tissue 1 and/or 2 result in the thyrotoxic clinical state, manifested by weight loss despite increased caloric intake; heat intolerance due to increased calorigenesis; cardiac tachyarrhythmias, systolic hypertension, and heart failure; skeletal muscle weakness; and a spectrum of neuropsychiatric symptoms ranging from anxiety to delirium and psychosis...
2009: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/19296014/mania-as-a-presentation-of-primary-hypothyroidism
#8
A Sathya, R Radhika, S Mahadevan, Un Sriram
Hypothyroidism is a common problem in clinical practice, with diverse manifestations. Neuropsychiatric problems include affective disorders, disturbances in cognition and psychosis. Mania is commonly associated with hyperthyroidism. Only a few selected case reports mention mania as a presenting feature of hypothyroidism. We report a case of mania with psychotic symptoms in a 47-year-old woman who had no previous history of psychiatric disorder. She had signs of florid hypothyroidism. She required both antipsychotic drugs and thyroxine replacement for the amelioration of her symptoms...
February 2009: Singapore Medical Journal
https://www.readbyqxmd.com/read/15948573/-hyperthyroidism-in-the-elderly-aspecific-signs-may-cause-a-delay-in-diagnosis
#9
F P Rozendaal
The clinical manifestations of thyroid diseases in the elderly are often atypical and can easily be attributed to other medical conditions or 'normal aging'. Two nursing home patients with hyperthyroidism are described. Due to the atypical presentation of the thyroid disease their complaints were attributed to other conditions. In both patients there was a significant delay in diagnosis and treatment of hyperthyroidism. In elder patients signs and symptoms of thyreotoxicosis are frequently related to cardiovascular, gastrointestinal and neuropsychiatric disorders...
May 2005: Tijdschrift Voor Gerontologie en Geriatrie
https://www.readbyqxmd.com/read/14103721/-eeg-and-the-neuropsychiatric-examination-of-patients-with-hyperthyroidism
#10
M POLICZER, E MOUSSONG KOVACS, E BAZSO, M MARTON
No abstract text is available yet for this article.
December 1, 1963: Orvosi Hetilap
https://www.readbyqxmd.com/read/8910812/hyperthyroidism-in-children-an-indian-experience
#11
P S Menon, G R Singh
During the period 1986-1993, 24 children with hyperthyroidism were referred to us for management. Two of them had factitious hyperthyroidism, one toxic nodular goiter and another neonatal Graves' disease. Twenty children (6M, 14F) had Graves' disease. Their age at presentation was 10.86 +/- 2.02 years and duration of symptoms ranged from 2.5 months to 7 years. Neuropsychiatric manifestations, such as hyperkinesis, irritability, excitability and behavioral problems, were the most common initial presenting symptoms (90%)...
July 1996: Journal of Pediatric Endocrinology & Metabolism: JPEM
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