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https://www.readbyqxmd.com/read/27923447/amelioration-of-non-alcoholic-fatty-liver-disease-with-npc1l1-targeted-igy-or-n-3-polyunsaturated-fatty-acids-in-mice
#1
Jin-Sik Bae, Jong-Min Park, Junghoon Lee, Byung-Chul Oh, Sang-Ho Jang, Yun Bin Lee, Young-Min Han, Chan-Young Ock, Ji-Young Cha, Ki-Baik Hahm
Patients with non-alcoholic fatty liver disease (NAFLD) have an increased risk for progression to hepatocellular carcinoma in addition to comorbidities such as cardiovascular and serious metabolic diseases; however, the current therapeutic options are limited. Based on our previous report that omega-3 polyunsaturated fatty acids (n-3 PUFAs) can significantly ameliorate high fat diet (HFD)-induced NAFLD, we explored the therapeutic efficacy of n-3 PUFAs and N-IgY, which is a chicken egg yolk-derived IgY specific for the Niemann-Pick C1-Like 1 (NPC1L1) cholesterol transporter, on NAFLD in mice...
January 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27918412/eggs-and-health-special-issue
#2
EDITORIAL
Maria Luz Fernandez
In 1968, the American Heart Association recommended the consumption of no more than 300 mg/day of dietary cholesterol and emphasized that no more than 3 eggs should be eaten per week, resulting in substantial reductions in egg consumption, not just by diseased populations but alsobyhealthyindividuals,andmoreimportantlybypoorcommunitiesinundevelopedcountieswho were advised against consuming a highly nutritious food.[...].
December 2, 2016: Nutrients
https://www.readbyqxmd.com/read/27914517/effect-of-flaxseed-oil-and-microalgae-dha-on-the-production-performance-fatty-acids-and-total-lipids-of-egg-yolk-and-plasma-in-laying-hens
#3
M Neijat, O Ojekudo, J D House
The incorporation of omega-3 polyunsaturated fatty acids (PUFA) in the egg is dependent on both the transfer efficiency of preformed dietary omega-3 fatty acids to the eggs as well as endogenous PUFA metabolism and deposition. Employing an experimental design consisting of 70 Lohmann LSL-Classic hens (n=10/treatment) in a 6-week feeding trial, we examined the impact of graded levels of either flaxseed oil (alpha-linolenic acid, ALA) or algal DHA (preformed docosahexaenoic acid, DHA), each supplying 0.20%, 0...
December 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27896589/lipid-nanoparticles-loaded-with-an-antisense-oligonucleotide-gapmer-against-bcl-2-for-treatment-of-lung-cancer
#4
Xinwei Cheng, Qibing Liu, Hong Li, Chen Kang, Yang Liu, Tianqi Guo, Ke Shang, Chengyun Yan, Guang Cheng, Robert J Lee
PURPOSE: Bcl-2 is an anti-apoptotic gene that is frequently overexpressed in human cancers. G3139 is an antisense oligonucleotide against bcl-2 that has shown limited efficacy in clinical trials. Here, we report the synthesis of a new antisense oligonucleotide containing additional chemical modifications and its delivery using nanoparticles. METHODS: An oligonucleotide G3139-GAP was synthesized, which has 2'-O-methyl nucleotides at the 5' and 3' ends based on a "gapmer" design...
November 28, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27864237/effect-of-selected-clinical-trial-publication-on-adjunctive-nonstatin-medication-prescribing-in-the-veterans-health-administration-system
#5
Krystal S Titus-Rains, Matthew A Cantrell, Jason A Egge, Bruce Alexander, Robert F Shaw, Tami R Argo
PURPOSE: The question of whether publication of selected clinical trials is temporally followed by changes in prescribing of adjunctive lipid-lowering medications was evaluated. METHODS: In this retrospective preanalysis and postanalysis, Veterans Health Administration (VHA) patients 18 years or older who received a new or renewed order for any lipid-lowering medication between April 2, 2004, and September 2, 2014, were included. This period was chosen based on the publication dates of three trials investigating the efficacy of nonstatin medications: Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia (ENHANCE, April 3, 2008), Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus (ACCORD Lipid, March 14, 2010), and Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy (AIM-HIGH, December 15, 2011)...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27855315/dietary-sphingomyelin-attenuates-hepatic-steatosis-and-adipose-tissue-inflammation-in-high-fat-diet-induced-obese-mice
#6
Gregory H Norris, Caitlin M Porter, Christina Jiang, Courtney L Millar, Christopher N Blesso
Western-type diets can induce obesity and related conditions such as dyslipidemia, insulin resistance and hepatic steatosis. We evaluated the effects of milk sphingomyelin (SM) and egg SM on diet-induced obesity, the development of hepatic steatosis and adipose inflammation in C57BL/6J mice fed a high-fat, cholesterol-enriched diet for 10 weeks. Mice were fed a low-fat diet (10% kcal from fat) (n=10), a high-fat diet (60% kcal from fat) (HFD, n=14) or a high-fat diet modified to contain either 0.1% (w/w) milk SM (n=14) or 0...
October 24, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27819218/performance-and-egg-quality-of-laying-hens-fed-flaxseed-highlights-on-n-3-fatty-acids-cholesterol-lignans-and-isoflavones
#7
S Mattioli, S Ruggeri, B Sebastiani, G Brecchia, A Dal Bosco, A Cartoni Mancinelli, C Castellini
Flaxseed is a rich source of α-linolenic acid and phytoestrogens, mainly lignans, whose metabolites (enterodiol and enterolactone) can affect estrogen functions. The present study evaluated the influence of dietary flaxseed supplementation on reproductive performance and egg characteristics (fatty acids, cholesterol, lignans and isoflavones) of 40 Hy-Line hens (20/group) fed for 23 weeks a control diet or the same diet supplemented with 10% of extruded flaxseed. The flaxseed diet had approximately three times the content of lignans (2608...
November 7, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27816933/effects-of-dynamic-feeding-low-and-high-methionine-diets-on-egg-quality-traits-in-laying-hens
#8
Y Liu, X Lin, X Zhou, D Wan, Z Wang, X Wu, Y Yin
This study was conducted to investigate effects of dynamic feeding low and high methionine (MET) diets on performance, egg quality traits, and serum metabolites in laying hens. A total of 180 laying hens (Brown Hy-line, 41 wk old) were allocated into 3 equal groups with 6 replicates each. The average egg production (EP) of each group was around 87% during one-week statistics before the formal experiment (P = 0.989). The control group (CON) received the control diet (contained 0.30% MET) at both 07:30 h and 15:30 hours...
November 5, 2016: Poultry Science
https://www.readbyqxmd.com/read/27790703/the-effect-of-fermented-buckwheat-on-producing-l-carnitine-and-gamma-aminobutyric-acid-gaba-enriched-designer-eggs
#9
Namhyeon Park, Tae-Kyung Lee, Thi Thanh Hanh Nguyen, Eun-Bae An, Nahyun M Kim, Young-Hyun You, Tae-Sub Park, Doman Kim
BACKGROUND: The potential of fermented buckwheat as feed additives was studied to increase L-carnitine and gamma-aminobutyric acid (GABA) in designer eggs. Buckwheat contains high levels of lysine, methionine, and glutamate, which are precursors for the synthesis of L-carnitine and GABA. Rhizopus oligosporus was used for the fermentation of buckwheat to produce L-carnitine and GABA that exert positive effects like enhanced metabolism, antioxidant activities, immunity, and blood pressure control...
October 28, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27788010/resveratrol-interaction-with-lipid-bilayers-a-synchrotron-x-ray-scattering-study
#10
Ana Rute Neves, Cláudia Nunes, Heinz Amenitsch, Salette Reis
Resveratrol belongs to the large group of biologically active polyphenol compounds with several health beneficial effects including anti-oxidant activity, anti-inflammatory action, cardiovascular protection, neuroprotection and cancer chemoprevention. In the present study it is raised the possibility that the effects of resveratrol described above are caused by resveratrol membrane interactions and structural modifications of lipid bilayers. In this context, it is possible that resveratrol interacts selectively with lipid domains present in biological membranes, thereby modulating the localization of the anchored proteins and controlling their intracellular cascades...
October 27, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27777066/psoralen-loaded-liposomal-nanocarriers-for-improved-skin-penetration-and-efficacy-of-topical-puva-in-psoriasis
#11
Sindhu Doppalapudi, Anjali Jain, Dhiraj Kumar Chopra, Wahid Khan
Psoralen in combination with ultraviolet A radiation (PUVA) is an FDA recommended therapy for clinical application in the management of severe recalcitrant psoriasis. Psoralen acts by intercalation of DNA and upon exposure to UV-A, it forms monoadducts which inturn induce apoptosis. Poor skin deposition, weak percutaneous permeability of psoralen and adverse effects of severe burning, blisters, pigmentation associated with conventional topical psoralen vehicles hinders the therapeutic efficacy and safety of topical PUVA...
October 21, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27744603/single-and-combined-impacts-of-vitamin-a-and-selenium-in-diet-on-productive-performance-egg-quality-and-some-blood-parameters-of-laying-hens-during-hot-season
#12
Mohamed E Abd El-Hack, Khalid Mahrose, Ali A Askar, Mahmoud Alagawany, Muhammad Arif, Muhammad Saeed, Farzana Abbasi, Rab Nawaz Soomro, Farman Ali Siyal, Maria Tabassum Chaudhry
A study was conducted using 162 Bovans laying hens to investigate the impacts of extra dietary vitamin A (0, 8000, 16,000 IU/kg), selenium (0, 0.25, 0.50 mg/kg), and their combinations on the performance, egg quality, and blood biological parameters of laying hens during summer months. Supplemental vitamin A up to 16,000 IU/kg diet significantly (P < 0.05) improved all productive traits studied except feed intake which increased with 8000 IU/kg diet compared with control. Feed intake and feed conversion of hens fed diet supplemented with selenium revealed high statistical (P = 0...
October 15, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27717410/metabolic-effects-of-quail-eggs-in-diabetes-induced-rats-comparison-with-chicken-eggs
#13
Eric Lontchi-Yimagou, Agatha Tanya, Carine Tchankou, Judith Ngondi, Julius Oben
BACKGROUND: Quail eggs as a food item have recently been introduced into the diet of some Cameroonians. These eggs are being sold in local markets, but with many unfounded health claims. One claim is that quail eggs can reduce blood glucose levels in diabetics. It was therefore necessary to evaluate the effect of consuming quail eggs on blood glucose levels, lipid profiles, and oxidative stress parameters in diabetes-induced rats. METHODS: Twenty Wistar rats weighing, on average, 250 g were divided into four groups of five rats each...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27712660/effect-of-cyclical-cold-stress-during-embryonic-development-on-aspects-of-physiological-responses-and-hsp70-gene-expression-of-chicks
#14
Keyvan Aminoroaya, Ali Asghar Sadeghi, Zarbakht Ansari-Pirsaraei, Nasser Kashan
The objective of the present study was to evaluate the effects of cyclical lower incubation temperature at different embryonic ages on the hatchability, body and organs weights, thyroid hormones, and liver HSP70 gene expression of newly hatched chicks. In a completely randomized design, fertile eggs of a broiler breeder (34 weeks of age) were assigned to three treatment groups with six replicates and 145 eggs per each. The treatment groups were as: control group (C) that eggs were incubated at 37.6°C during the whole incubation period; incubation temperature was decreased to 36°C for 3h per day at embryonic age from 12 to 14 (T1); and incubation temperature was decreased to 36°C for 3h per day at embryonic age from 15 to 17 (T2)...
October 2016: Journal of Thermal Biology
https://www.readbyqxmd.com/read/27710205/meta-analysis-of-egg-consumption-and-risk-of-coronary-heart-disease-and-stroke
#15
Dominik D Alexander, Paula E Miller, Ashley J Vargas, Douglas L Weed, Sarah S Cohen
The possible relationship between dietary cholesterol and cardiac outcomes has been scrutinized for decades. However, recent reviews of the literature have suggested that dietary cholesterol is not a nutrient of concern. Thus, we conducted a meta-analysis of egg intake (a significant contributor to dietary cholesterol) and risk of coronary heart disease (CHD) and stroke. A comprehensive literature search was conducted through August 2015 to identify prospective cohort studies that reported risk estimates for egg consumption in association with CHD or stroke...
November 2016: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/27665008/effects-of-dietary-fats-on-egg-quality-and-lipid-parameters-in-serum-and-yolks-of-shan-partridge-duck
#16
Xue Du, Yali Liu, Lizhi Lu, Weiqun Wang, Tao Zeng, Yong Tian, Xiaoqin Xu, Jianliang Shen, Dong Niu, Yingru Lu
The effects of different dietary fats with variable levels of polyunsaturated fatty acids (PUFAs) on egg quality of Shan Partridge Duck, serum, and yolk lipid parameters were examined in this study. A flock of 585 optimal produced ducks were selected and diets enriched with 0.5%, 1%, or 2% fish oil (F)/flaxseed oil (FL)/rapeseed oil (R)/tallow (T) plus basal diet were supplied through a 28-d period. Supplemental fat source and fat level had no effects on egg qualities. Proportions of yolk total cholesterol (TC), saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) were reduced (P < 0...
September 24, 2016: Poultry Science
https://www.readbyqxmd.com/read/27636857/nutritional-characteristics-and-quality-of-eggs-from-laying-hens-fed-on-a-diet-supplemented-with-chestnut-tannin-extract-castanea-sativa-miller
#17
S Minieri, A Buccioni, A Serra, I Galigani, A Pezzati, S Rapaccini, M Antongiovanni
The trial was performed with 80 laying hens belonging to two Tuscan autochthonous breeds: 40 birds of the Mugellese breed (MU) and 40 of the White Leghorn breed (WL). The animals were allotted to 4 groups of 20 hens each: two groups were fed on a commercial diet and worked as the control groups (MUC and WLC); the other two groups received the same diet, integrated with 2 g of chestnut tannin extract per kg of diet (MUT and WLT). A sample of 70 eggs were randomly collected and analysed for cholesterol content, fatty acid profile, weight, thickness of shell and colour of yolk...
September 16, 2016: British Poultry Science
https://www.readbyqxmd.com/read/27627075/-changes-in-nutritional-recommendations-for-a-healthy-population-and%C3%A2-their-influence-on-a-diabetic-diet
#18
Michal Anděl, Ludmila Brunerová, Pavel Dlouhý, Jan Polák, Jan Gojda, Pavel Kraml
UNLABELLED: Recently, thousands of papers brought knowledge about effects of nutrients on cellular level, in experimental animals and in human experiments on one side, the results of epidemiological studies on the other side have suggested the nutrients and foods for healthy diet and nutrients and foods, which should be consumed only in limited amount. Among foods, which should be avoided, those with higher content of trans-fatty acids. Their daily intake should not exceed 1 % of total energy intake...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27623952/changes-in-biochemical-analytes-in-female-dogs-with-subclinical-ancylostoma-spp-infection
#19
Elizabeth M S Schmidt, Asta Tvarijonaviciute, Silvia Martinez-Subiela, José J Cerón, Peter D Eckersall
BACKGROUND: Ancylostoma spp. is one of the most prevalent canine intestinal nematode infections which usually causes subclinical disease in adult dogs and has zoonotic implications. Therefore, the aim of this study was to explore and evaluate the possible pathophysiological changes that Ancylostoma spp. could produce in female dogs naturally infected but without clinical signs of disease, by screening a wide variety of biochemical markers for potential changes. Samples of feces and blood of 45 dogs were collected and fecal flotation and zinc sulphate centrifugal flotation were performed...
2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27609706/dietary-factors-reduce-risk-of-acute-pancreatitis-in-a-large-multiethnic-cohort
#20
Veronica Wendy Setiawan, Stephen J Pandol, Jacqueline Porcel, Pengxiao C Wei, Lynne R Wilkens, Loïc Le Marchand, Malcolm C Pike, Kristine R Monroe
BACKGROUND & AIMS: Pancreatitis is a source of substantial morbidity and health cost in the United States. Little is known about how diet might contribute to its pathogenesis. To characterize dietary factors that are associated with risk of pancreatitis by disease subtype, we conducted a prospective analysis of 145,886 African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites in the Multiethnic Cohort. METHODS: In the Multiethnic Cohort (age at baseline, 45-75 y), we identified cases of pancreatitis using hospitalization claim files from 1993 through 2012...
September 5, 2016: Clinical Gastroenterology and Hepatology
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