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procalcitonin sepsis

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https://www.readbyqxmd.com/read/28203255/the-influencing-factors-on-procalcitonin-values-in-newborns-with-noninfectious-conditions-during-the-first-week-of-life
#1
Jueseong Lee, Yong Hyeon Bang, Eun Hee Lee, Byung Min Choi, Young Sook Hong
PURPOSE: Although procalcitonin (PCT) level is useful for the diagnosis of neonatal sepsis, PCT reliability is inconsistent because of the varied conditions encountered in neonatal intensive care units. This study aimed to investigate PCT levels and factors influencing increased PCT levelin newborns without bacterial infection during the first week of life. METHODS: In newborns hospitalized between March 2013 and October 2015, PCT levels were measured on the first, third, and seventh days after birth...
January 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28202856/plasma-monocyte-chemoattractant-protein-1-as-a-predictive-marker-for-sepsis-prognosis-a-prospective-cohort-study
#2
Tingting Zhu, Xuelian Liao, Ting Feng, Qihong Wu, Jiangqian Zhang, Xing Cao, Hong Li
Sepsis is a systemic host response to infection, and patients with sepsis are frequently handled in the intensive care unit. However, mortality related to sepsis remains high throughout the world. In addition, there have been no efficient prognostic biomarkers for sepsis to be employed in clinical practice. We therefore aimed to identify prognostic biomarkers for sepsis using the chemokine/cytokine array. This study included 143 patients with sepsis, who were divided into survivor and nonsurvivor groups according to their 28-day mortality status...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28192449/timp1-and-mmp9-are-predictors-of-mortality-in-septic-patients-in-the-emergency-department-and-intensive-care-unit-unlike-mmp9-timp1-ratio-multivariate-model
#3
Maria Eugenia Niño, Sergio Eduardo Serrano, Daniela Camila Niño, Diana Margarita McCosham, Maria Eugenia Cardenas, Vivian Poleth Villareal, Marcos Lopez, Antonio Pazin-Filho, Fabian Alberto Jaimes, Fernando Cunha, Richard Schulz, Diego Torres-Dueñas
INTRODUCTION: Matrix metalloproteinases and tissue inhibitors of metalloproteinases could be promising biomarkers for establishing prognosis during the development of sepsis. It is necessary to clarify the relationship between matrix metalloproteinases and their tissue inhibitors. We conducted a cohort study with 563 septic patients, in order to elucidate the biological role and significance of these inflammatory biomarkers and their relationship to the severity and mortality of patients with sepsis...
2017: PloS One
https://www.readbyqxmd.com/read/28185230/superior-accuracy-of-mid-regional-proadrenomedullin-for-mortality-prediction-in-sepsis-with-varying-levels-of-illness-severity
#4
David Andaluz-Ojeda, H Bryant Nguyen, Nicolas Meunier-Beillard, Ramón Cicuéndez, Jean-Pierre Quenot, Dolores Calvo, Auguste Dargent, Esther Zarca, Cristina Andrés, Leonor Nogales, Jose María Eiros, Eduardo Tamayo, Francisco Gandía, Jesús F Bermejo-Martín, Pierre Emmanuel Charles
BACKGROUND: The use of novel sepsis biomarkers has increased in recent years. However, their prognostic value with respect to illness severity has not been explored. In this work, we examined the ability of mid-regional proadrenomedullin (MR-proADM) in predicting mortality in sepsis patients with different degrees of organ failure, compared to that of procalcitonin, C-reactive protein and lactate. METHODS: This was a two-centre prospective observational cohort, enrolling severe sepsis or septic shock patients admitted to the ICU...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28164563/cell-free-dna-and-procalcitonin-as-early-markers-of-complications-in-icu-patients-with-multiple-trauma-and-major-surgery
#5
Asmaa I Ahmed, Randa A Soliman, Shereif Samir
BACKGROUND: Cell free DNA (cfDNA) was recently suggested as a new marker of sepsis and poor outcome in ICU patients. Procalcitonin has also been the focus of attention as an early marker for systemic inflammation and sepsis. METHODS: cfDNA, procalcitonin (PCT), C-reactive protein (CRP), and lactate levels were measured in 30 ICU patients with multiple trauma or after major surgery on the first day of admission and on 5th and 7th days for PCT, CRP, and lactate. cfDNA was measured by real-time PCR, PCT by ELISA, CRP immunoturbidimetrically, and lactate spectrophotometrically...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28161884/usefulness-of-procalcitonin-in-differentiating-candida-and-bacterial-blood-stream-infections-in-critically-ill-septic-patients-outside-the-intensive-care-unit
#6
Filippo Pieralli, Lorenzo Corbo, Arianna Torrigiani, Dario Mannini, Elisa Antonielli, Antonio Mancini, Francesco Corradi, Fabio Arena, Alberto Moggi Pignone, Alessandro Morettini, Carlo Nozzoli, Gian Maria Rossolini
We aimed to explore the role of procalcitonin (PCT) for the diagnosis of Candida spp. bloodstream infections in a population of critically ill septic patients admitted to internal medicine units. This is a retrospective case-control study considering all cases of candidemia identified in three internal medicine units, from January 1st 2012 to May 31st 2016. For each case of candidemia, two patients with bacteremic sepsis were included in the study as control cases. The end point of the study was to evaluate the diagnostic performance of PCT for the diagnosis of Candida spp...
February 4, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28155994/pancreatic-stone-protein-and-soluble-cd25-for-infection-and-sepsis-in-an-emergency-department
#7
Luis García de Guadiana-Romualdo, Mario Berger, Enrique Jiménez-Santos, Sergio Rebollo-Acebes, Roberto Jiménez-Sánchez, Patricia Esteban-Torrella, Ana Hernando-Holgado, Alejandro Ortín-Freire, María Dolores Albaladejo-Otón
BACKGROUND: Infection is a common problem in Emergency Departments (ED) and is associated with high mortality, morbidity and costs. Identifying infection in ED patients can be challenging. Biomarkers can facilitate its diagnosis, enabling an early management and improving outcomes. In the critical care setting, two emerging biomarkers, pancreatic stone protein (PSP) and soluble CD25 (sCD25), have demonstrated to be useful for diagnosis of sepsis. We aimed to assess the diagnostic value of these biomarkers, in comparison to procalcitonin (PCT), for infection and sepsis in an ED population with suspected infection...
February 3, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28153679/evaluating-the-value-of-dynamic-procalcitonin-and-presepsin-measurements-for-patients-with-severe-sepsis
#8
Han Yu, Zhijiang Qi, Chenchen Hang, Yingying Fang, Rui Shao, Chunsheng Li
OBJECTIVE: This study comparatively evaluated the value of dynamic procalcitonin (PCT) and presepsin measurements in assessing therapeutic efficacy and prognosis for patients with severe sepsis. METHODS: Patients with severe sepsis (n=109) were enrolled and divided into survival and non-survival groups based on 90-day survival. PCT and presepsin levels were evaluated on days 1, 3, 5, 7, and 12. Sequential organ failure assessment (SOFA) was calculated. RESULTS: PCT from day 5 onward was weakly to moderately positively correlated with SOFA, whereas presepsin from day 3 onward was positively correlated...
January 22, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28135842/annals-express-diagnostic-accuracy-of-lipopolysaccharide-binding-protein-for-sepsis-in-patients-with-suspected-infection-in-the-emergency-department
#9
Luis García de Guadiana Romualdo, María Dolores Albaladejo Otón, Sergio Rebollo Acebes, Patricia Esteban Torrella, Ana Hernando-Holgado, Enrique Jiménez Santos, Roberto Jiménez Sánchez, Alejandro Ortín Freire
BACKGROUND: Biomarkers can facilitate the diagnosis of sepsis, enabling early management and improving outcomes. Lipopolysaccharide binding protein (LBP) has been reported as a biomarker for detection of infection, but its diagnostic value is controversial. In this study, we assessed the diagnostic accuracy of LBP for sepsis in emergency department (ED) patients, comparing it with more established biomarkers of sepsis, including procalcitonin (PCT) and C-reactive protein (CRP). METHODS: LBP and other sepsis biomarkers, including PCT and CRP, were measured on admission in 102 adult patients presenting with suspected infection...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28131458/biomarkers-for-the-diagnosis-of-neonatal-sepsis-and-necrotizing-entercolitis-clinical-practice-guidelines
#10
Margaret Gilfillan, Vineet Bhandari
Sepsis and necrotizing enterocolitis are major contributors to morbidity and mortality in neonates, especially in those born preterm. While therapeutic interventions are available for both (for e.g. antibiotics), a major dilemma is early diagnosis so that these interventions can be done in a timely manner. As clinical evaluation alone is unreliable in identifying infants in the early stages of neonatal sepsis or necrotizing enterocolitis, there is a need to find specific biomarkers associated with these conditions to improve diagnostic capabilities...
January 25, 2017: Early Human Development
https://www.readbyqxmd.com/read/28128911/emergency-percutaneous-nephrostomy-versus-emergency-percutaneous-nephrolithotomy-in-patients-with-sepsis-associated-with-large-uretero-pelvic-junction-stone-impaction-a-randomized-controlled-trial
#11
Chi-Sen Hsu, Chung-Jing Wang, Chien-Hsing Chang, Po-Chao Tsai, Hung-Wen Chen, Yi-Chun Su
INTRODUCTION: A randomized trial was conducted prospectively to evaluate the efficacy, related complications, and convalescence of emergency percutaneous nephrolithotomy compared to percutaneous nephrostomy for decompression of the collecting system in cases of sepsis associated with large uretero-pelvic junction stone impaction. MATERIALS AND METHODS: The inclusion criteria included a WBC count of 10.000/mm3 or more and/or a temperature of 38°C or higher. Besides, all enrolled patients should maintain stable hemodynamic status and proper organ perfusions...
January 27, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28124966/-a-case-of-bronchiolitis-obliterans-secondary-to-human-metapneumovirus-bronchiolitis
#12
Osman Yeşilbaş, Esra Şevketoğlu, Hasan Serdar Kıhtır, Mey Talip Petmezci, Elif Bato, Seda Balkaya, Nevin Hatipoğlu, Mert Ahmet Kuşkucu, Figen Palabıyık, Erkan Çakır
Human metapneumovirus (hMPV), formerly classified in Paramyxoviridae family is now moved into Pneumoviridae, which was described as a novel family. It causes upper and lower respiratory tract infections (LRTIs) usually in children younger than five years old. The recent epidemiological studies indicated that hMPV is the second most frequently detected virus in LRTIs of young children, following the respiratory syncytial virus (RSV). Bronchiolitis obliterans (BO) is a chronic obstructive lung disease characterized by fibrosis of the distal respiratory airways...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28120568/long-pentraxin-3-as-a-predictive-marker-of-mortality-in-severe-septic-patients-who-received-successful-early-goal-directed-therapy
#13
Sun Bean Kim, Kyoung Hwa Lee, Ji Un Lee, Hea Won Ann, Jin Young Ahn, Yong Duk Jeon, Jung Ho Kim, Nam Su Ku, Sang Hoon Han, Jun Yong Choi, Young Goo Song, June Myung Kim
PURPOSE: Pentraxin 3 (PTX3) has been suggested to be a prognostic marker of mortality in severe sepsis. Currently, there are limited data on biomarkers including PTX3 that can be used to predict mortality in severe sepsis patients who have undergone successful initial resuscitation through early goal-directed therapy (EGDT). MATERIALS AND METHODS: A prospective cohort study was conducted among 83 severe sepsis patients with fulfillment of all EGDT components and the achievement of final goal...
March 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28114931/procalcitonin-guided-diagnosis-and-antibiotic-stewardship-revisited
#14
REVIEW
Ramon Sager, Alexander Kutz, Beat Mueller, Philipp Schuetz
Several controlled clinical studies have evaluated the potential of the infection biomarker procalcitonin (PCT) to improve the diagnostic work-up of patients with bacterial infections and its influence on decisions regarding antibiotic therapy. Most research has focused on lower respiratory tract infections and critically ill sepsis patients. A clinical utility for PCT has also been found for patients with urinary tract infections, postoperative infections, meningitis, and patients with acute heart failure with possible superinfection (i...
January 24, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28099689/effectiveness-and-safety-of-procalcitonin-evaluation-for-reducing-mortality-in-adults-with-sepsis-severe-sepsis-or-septic-shock
#15
REVIEW
Brenda Ng Andriolo, Regis B Andriolo, Reinaldo Salomão, Álvaro N Atallah
BACKGROUND: Serum procalcitonin (PCT) evaluation has been proposed for early diagnosis and accurate staging and to guide decisions regarding patients with sepsis, severe sepsis and septic shock, with possible reduction in mortality. OBJECTIVES: To assess the effectiveness and safety of serum PCT evaluation for reducing mortality and duration of antimicrobial therapy in adults with sepsis, severe sepsis or septic shock. SEARCH METHODS: We searched the Central Register of Controlled Trials (CENTRAL; 2015, Issue 7); MEDLINE (1950 to July 2015); Embase (Ovid SP, 1980 to July 2015); Latin American Caribbean Health Sciences Literature (LILACS via BIREME, 1982 to July 2015); and the Cumulative Index to Nursing and Allied Health Literature (CINAHL; EBSCO host, 1982 to July 2015), and trial registers (ISRCTN registry, ClinicalTrials...
January 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28099644/use-of-biomarkers-in-pediatric-sepsis-literature-review
#16
Vanessa Soares Lanziotti, Pedro Póvoa, Márcio Soares, José Roberto Lapa E Silva, Arnaldo Prata Barbosa, Jorge Ibrain Figueira Salluh
Despite advances in recent years, sepsis is still a leading cause of hospitalization and mortality in infants and children. The presence of biomarkers during the response to an infectious insult makes it possible to use such biomarkers in screening, diagnosis, prognosis (risk stratification), monitoring of therapeutic response, and rational use of antibiotics (for example, the determination of adequate treatment length). Studies of biomarkers in sepsis in children are still relatively scarce. This review addresses the use of biomarkers in sepsis in pediatric patients with emphasis on C-reactive protein, procalcitonin, interleukins 6, 8, and 18, human neutrophil gelatinase, and proadrenomedullin...
October 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28099244/presepsin-scd14-st-is-a-novel-marker-for-risk-stratification-in-cardiac-surgery-patients
#17
Hagen Bomberg, Matthias Klingele, Stefan Wagenpfeil, Eberhard Spanuth, Thomas Volk, Daniel I Sessler, Hans-Joachim Schäfers, Heinrich Volker Groesdonk
BACKGROUND: Presepsin (soluble cluster-of-differentiation 14 subtype [sCD14-ST]) is a humoral risk stratification marker for systemic inflammatory response syndrome and sepsis. It remains unknown whether presepsin can be used to stratify risk in elective cardiac surgery. The authors therefore determined the usefulness of presepsin for risk stratification in patients having elective cardiac surgery. METHODS: Eight hundred fifty-six cardiac surgical patients were prospectively studied...
January 18, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28079172/25-oh-d-and-1-25-oh-d-vitamin-d-fails-to-predict-sepsis-and-mortality-in-a-prospective-cohort-study
#18
Franz Ratzinger, Helmuth Haslacher, Markus Stadlberger, Ralf L J Schmidt, Markus Obermüller, Klaus G Schmetterer, Thomas Perkmann, Athanasios Makristathis, Rodrig Marculescu, Heinz Burgmann
The clinical role of vitamin D in sepsis and mortality prediction is controversially discussed. Therefore, we conducted a prospective cohort study on standard care wards, including 461 patients with suspected sepsis fulfilling two or more SIRS criteria. On the first and third day after onset of SIRS symptoms levels of 25(OH)D, 1,25(OH)D and sepsis biomarkers were analysed for their predictive capacity for identifying infection, bacteraemia and an elevated mortality risk. Additionally, several SNPs associated with vitamin D metabolism were evaluated...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28076309/activation-of-the-tryptophan-serotonin-pathway-is-associated-with-severity-and-predicts-outcomes-in-pneumonia-results-of-a-long-term-cohort-study
#19
Marc A Meier, Manuel Ottiger, Alaadin Vögeli, Christian Steuer, Luca Bernasconi, Robert Thomann, Mirjam Christ-Crain, Christoph Henzen, Claus Hoess, Werner Zimmerli, Andreas Huber, Beat Mueller, Philipp Schuetz
BACKGROUND: As part of the immune defense during infection, an increase in enzyme activity of indoleamine 2,3-dioxygenase (IDO) leads to a breakdown of tryptophan to kynurenine. In previous animal studies, therapeutic antagonism of IDO resulted in reduced sepsis mortality. We investigated the prognostic ability of tryptophan, serotonin, kynurenine and IDO (represented by the ratio of kynurenine/tryptophan) to predict adverse clinical outcomes in patients with community-acquired pneumonia (CAP)...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28045978/cord-blood-acute-phase-reactants-predict-early-onset-neonatal-sepsis-in-preterm-infants
#20
Leena B Mithal, Hannah L Palac, Ram Yogev, Linda M Ernst, Karen K Mestan
BACKGROUND: Early onset sepsis (EOS) is a major cause of morbidity and mortality in preterm infants, yet diagnosis remains inadequate resulting in missed cases or prolonged empiric antibiotics with adverse consequences. Evaluation of acute phase reactant (APR) biomarkers in umbilical cord blood at birth may improve EOS detection in preterm infants with intrauterine infection. METHODS: In this nested case-control study, infants (29.7 weeks gestation, IQR: 27.7-32...
2017: PloS One
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