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procalcitonin sepsis

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https://www.readbyqxmd.com/read/28521523/sepsis-in-internal-medicine-wards-current-knowledge-uncertainties-and-new-approaches-for-management-optimization
#1
Vincenzo Zaccone, Alberto Tosoni, Giovanna Passaro, Carla Vallone, Michele Impagnatiello, Domenica Donatella Li Puma, Salvatore De Cosmo, Raffaele Landolfi, Antonio Mirijello
Sepsis represents a global health problem in terms of morbidity, mortality, social and economic costs. Although usually managed in Intensive Care Units, sepsis showed an increased prevalence among Internal Medicine wards in the last decade. This is substantially due to the ageing of population and to multi-morbidity. These characteristics represent both a risk factor for sepsis and a relative contra-indication for the admission to Intensive Care Units. Although there is a lack of literature on the management of sepsis in Internal Medicine, the outcome of these patients seems to be gradually improving...
May 18, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28520525/companion-and-point-of-care-sensor-system-for-rapid-multiplexed-detection-of-a-panel-of-infectious-disease-markers
#2
Anjan Panneer Selvam, Shalini Prasad
A nanochannel-based electrochemical biosensor has been demonstrated for rapid and multiplexed detection of a panel of three biomarkers associated with rapid detection of sepsis. The label-free biosensor detected procalcitonin (PCT), lipoteichoic acid (LTA), and lipopolysaccharide (LPS) from human whole blood. The biosensor comprises a nanoporous nylon membrane integrated onto a microelectrode sensor platform for nanoconfinement effects. Charge perturbations due to biomarker binding are recorded as impedance changes using electrochemical impedance spectroscopy...
June 2017: SLAS Technology
https://www.readbyqxmd.com/read/28505020/the-role-of-thioredoxin-1-in-suppression-sepsis-through-inhibiting-mitochondrial-induced-apoptosis-in-spleen
#3
Guobing Chen, Xiang Li, Mengbing Huang, Xiaoshuang Zhou, Ye Li, Xiaoqin Mao, Jie Bai
Sepsis is a serious public health issue and the leading cause of death in critically ill patients in intensive care units. Thioredoxin-1 (Trx-1) is a protein of regulating redox, as well as a modulator of inflammation and apoptosis. Our previous study reported that Trx-1 decreased endoplasmic reticulum-mediated inflammation involved in lung in a model of experimental sepsis. However, its effect on mitochondrial-mediated apoptosis in spleen has not been reported. We studied whether Trx-1 could prevent spleen cells apoptosis in sepsis...
June 2017: Shock
https://www.readbyqxmd.com/read/28504925/comparative-diagnostic-test-evaluation-of-serum-procalcitonin-and-c-reactive-protein-in-suspected-bloodstream-infections-in-children-with-cancer
#4
Swapna R Nath, Sabeena Jayapalan, Harikumaran Nair, P Kusumakumary, N S Prema, T Priyakumari, K Rajamohanan
PURPOSE: To compute diagnostic test properties of C-reactive protein (CRP) and serum procalcitonin (PCT) levels in bloodstream infections in children with cancer and suspected sepsis, in comparison with blood culture as the gold standard. METHODOLOGY: Consecutive paediatric cancer patients, aged ≤14 years, with clinically suspected bloodstream infections were evaluated with blood culture and assay of PCT and CRP levels. Blood culture was taken as the gold standard for comparison...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28504784/current-clinical-controversies-in-the-management-of-sepsis
#5
J Cohen
Sepsis remains a challenging clinical problem requiring prompt diagnosis and optimal clinical management if the continuing high mortality is to be contained. In this brief review I consider four specific questions that are the subject of ongoing controversy. First, whether the new 'Sepsis-3' definitions will be helpful, in particular in improving diagnosis, or whether the rapid move towards precision medicine will make the definition redundant. Second, should we routinely use combinations of antibiotics for the empiric treatment of sepsis...
December 2016: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/28502138/presepsin-a-diagnostic-marker-for-sepsis-in-intensive-care-unit-patients
#6
Hanaa A Amer, Hala Ghareeb, Neama M Lotfy, Noran O El-Azizi, Asmaa Mahmoud Mahmoud
The aim of the study was to evaluate the usefulness of presepsin as a diagnostic marker of sepsis in intensive care unit (ICU) patients. Presepsin was measured by a rapid method based on a chemiluminescent enzyme immunoassay (PATHFAST). The clinical usefulness of presepsin to diagnose sepsis and septic shock was studied and compared with procalcitonin, C-reactive protein and total leucocytic count. This study was conducted on 53 individuals divided into 3 groups. Group I included 28 adult ICU patients with at least two diagnostic criteria for systemic inflammatory response syndrome (SIRS) as patient group, Group IIa 15 patients admitted to ICU for any medical cause but with no evidence of infection were enrolled as patient control group and further 10 apparently healthy subjects as healthy control group...
June 2016: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/28500919/kinetics-of-circulating-fetuin-a-may-predict-mortality-independently-from-adiponectin-high-molecular-weight-adiponectin-and-prognostic-factors-in-critically-ill-patients-with-sepsis-a-prospective-study
#7
Irene Karampela, Evangelia Kandri, Georgios Antonakos, Evangelos Vogiatzakis, Gerasimos Socrates Christodoulatos, Athina Nikolaidou, George Dimopoulos, Apostolos Armaganidis, Maria Dalamaga
PURPOSE: Fetuin-A and adiponectin, major hepatokine and adipokine respectively, have been implicated in systematic inflammation. Our aim was to jointly investigate whether kinetics of circulating fetuin-A, adiponectin and its isoform HMWA predict 28-day mortality in sepsis. MATERIALS AND METHODS: In a prospective study, serum fetuin-A, adiponectin and HMWA were determined in 102 ICU patients fulfilling the diagnostic criteria of SEPSIS-3, at enrollment and one week after, and in 102 healthy controls matched on age and gender...
May 6, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28497010/a-review-of-the-value-of-procalcitonin-as-a-marker-of-infection
#8
REVIEW
Richard Taylor, Adriana Jones, Steven Kelly, Michael Simpson, Jordan Mabey
Septicemia is a growing problem within the United States (US), which increases mortality and the cost of care. Procalcitonin is a pro-inflammatory marker that could be useful in the diagnosis of infection. In the past, procalcitonin levels have been evaluated to diagnose sepsis or guide antibiotic therapy, but it was not determined if it would differentiate between sepsis and other causes of inflammation. Studies reviewed here showed procalcitonin to be a useful biomarker as an indication of bacterial infection...
April 10, 2017: Curēus
https://www.readbyqxmd.com/read/28486866/the-predictive-value-of-coefficient-of-pct-%C3%A3-bg-for-anastomotic-leak-in-esophageal-carcinoma-patients-with-ards-after-esophagectomy
#9
Huan Li, Daofeng Wang, Wenxiao Wei, Lamei Ouyang, Ning Lou
Anastomotic leak was a potentially severe life-threatening complication of esophagectomy, which drew attention in consequence of progressive dyspnea until acute respiratory distress syndrome (ARDS) due to the early asymptomatic presentation. Respiratory failure, caused by ARDS as the severe presentation of anastomotic leak, is the most common organ failure. CRP (C-reactive protein), procalcitonin (PCT), and Blood G (BG) test are the sensitivity markers for inflammatory, sepsis, and fungemia, respectively. Early recognition and intervention treatment of anastomotic leak may alleviate complication and improve outcome...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28484421/the-randomized-controlled-strawinski-trial-procalcitonin-guided-antibiotic-therapy-after-stroke
#10
Lena Ulm, Sarah Hoffmann, Darius Nabavi, Marcella Hermans, Bruno-Marcel Mackert, Frank Hamilton, Ingo Schmehl, Gerhard-Jan Jungehuelsing, Joan Montaner, Alejandro Bustamante, Mira Katan, Andreas Hartmann, Stefan Ebmeyer, Christiane Dinter, Jan C Wiemer, Sabine Hertel, Christian Meisel, Stefan D Anker, Andreas Meisel
BACKGROUND: Pneumonia is among the most common acute complications after stroke and is associated with poor long-term outcome. Biomarkers may help identifying stroke patients at high risk for developing stroke-associated pneumonia (SAP) and to guide early treatment. AIMS: This trial investigated whether procalcitonin (PCT) ultrasensitive (PCTus)-guided antibiotic treatment of SAP can improve functional outcome after stroke. METHODS: In this international, multicenter, randomized, controlled clinical trial with blinded assessment of outcomes, patients with severe ischemic stroke in the middle cerebral artery territory were randomly assigned within 40 h after symptom onset to PCTus-based antibiotic therapy guidance in addition to stroke unit care or standard stroke unit care alone...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28480245/using-procalcitonin-to-guide-antibiotic-therapy
#11
REVIEW
Chanu Rhee
Procalcitonin levels rise in response to systemic inflammation, especially of bacterial origin. Multiple randomized controlled trials have demonstrated that procalcitonin-based algorithms can safely reduce antibiotic use in 2 clinical scenarios. First, in stable, low-risk patients with respiratory infections, procalcitonin levels of <0.25 µg/L can guide the decision to withhold antibiotics or stop therapy early. Second, in critically ill patients with suspected sepsis, clinicians should not initially withhold antibiotics, but procalcitonin levels of <0...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28473224/the-n-terminal-pro-brain-natriuretic-peptide-is-the-best-predictor-of-mortality-during-hospitalization-in-patients-with-low-sepsis-related-organ-failure-assessment
#12
Eva García Villalba, Enrique Bernal Morell, Mari Paz Egea, Irene Marín, Antonia Alcaraz Garcia, Angeles Muñoz, MariCarmen Vera, Salvador Valero, Monica Martinez, Victoria Callejo Hurtado, Jose Miguel Gomez Verdu, Angela Santo, Alfredo Cano Sanchez
INTRODUCTION: The purpose of this study was to investigate the value of N-terminal pro brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP) and procalcitonin (PCT) in predicting mortality in septic patients during hospitalization with mortality risk<10% evaluated by Sepsis-related Organ Failure Assessment (SOFA). MATERIAL AND METHODS: Prospective, observational study performed in sepsis patients with SOFA risk<10%. We obtained levels of biomarkers in the first 72h after admission in hospital...
May 1, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28471985/the-clinical-significance-of-scd14-st-for-blood-biomarker-in-neonatal-hematosepsis-a-diagnostic-accuracy-study
#13
Ting Xiao, Li-Ping Chen, Li-Hua Zhang, Fu-Huang Lai, Li Zhang, Qun-Feng Qiu, Rong-Liang Que, SiSi Xie, Ding-Chang Wu
Hematosepsis is a systemic inflammatory response syndrome (SIRS) with suspected or confirmed infection, which is the most common infectious disease in clinical neonatal intensive care unit. As the rapid development of neonatal hematosepsis caused by various basic diseases, the mortality rate is high, and there are some sequelae.We report the lasted study to date with 96 cases from Fujian Longyan First Hospital between 2013 and 2015. The aim of our study is to explore the value of soluble cluster of differentiation 14 subtype (sCD14-ST) in whole blood for differential diagnosis of neonatal hematosepsis at an early stage, and used in evaluation of the severity about sepsis combined with acute physiology and chronic health evaluation II (APACHE-II) score, procalcitonin (PCT), C reactive protein (CRP), and leukocyte (WBC)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28459220/inflammatory-responses-and-histopathological-changes-in-a-mouse-model-of-staphylococcus-aureus-induced-bloodstream-infections
#14
Dan Wu, Shusheng Zhou, Shijing Hu, Bao Liu
INTRODUCTION: Staphylococcus aureus-induced bloodstream infections (BSIs) remain a prevalent clinical challenge and the underlying pathogenesis is still poorly understood. The aim of this study was to investigate the inflammatory responses and histopathological changes in BSIs in mice. METHODOLOGY: Male C57BL/6 mice were inoculated with S. aureus intravenously to induce BSIs. The survival rate, weight loss, and murine sepsis scores (MSS) were monitored in BSI and phosphate-buffered saline (PBS) control mice...
April 30, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28454850/procalcitonin-for-the-early-diagnosis-of-sepsis-in-burn-patients-a-retrospective-study
#15
Luís Cabral, Vera Afreixo, Filipe Santos, Luís Almeida, José Artur Paiva
BACKGROUND: The gold standard for sepsis diagnosis in burn patient still relies on microbiological cultures, which take 48-72h to provide results, delaying the start of antimicrobial therapy. Thus, biomarkers allowing an earlier sepsis diagnosis in burn patients are needed. METHODS: This retrospective observational study included 150 burn patients with total burned surface area ≥15%. Clinical diagnosis of sepsis among these patients was done according to the American Burn Association criteria...
April 25, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28443360/overview-of-procalcitonin-assays-and-procalcitonin-guided-protocols-for-the-management-of-patients-with-infections-and-sepsis
#16
Philipp Schuetz, Celine Bretscher, Luca Bernasconi, Beat Mueller
Procalcitonin is a surrogate infection blood marker whose levels help estimate the likelihood of bacterial infections and correlate with their resolution. Recent trials have revealed the benefits of inclusion of procalcitonin in antibiotic stewardship protocols for initiation and discontinuation of antimicrobial therapy. Areas covered: Procalcitonin-guided antibiotic stewardship protocols have shown appreciable reductions in antibiotic use and duration of therapy in respiratory infections, sepsis, and other infections, with positive effects on clinical outcomes...
May 3, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28442521/application-of-flow-cytometry-in-the-early-diagnosis-of-neonatal-sepsis
#17
Mustafa Aydin, Sumeyye Barut, H Handan Akbulut, Sit Ucar, Aysen Orman
GOALS: To raise awareness of the utility of flow cytometric detection of inflammatory markers in the early diagnosis of neonatal sepsis. PROCEDURES: In accordance with the Töllner scoring system, cases with ≥10 points are accepted as having "clinical sepsis" and cases with 0-4 points as having "no sepsis". The study group consisted of 50 newborns with clinical sepsis as well as a control group of 50 newborns without sepsis. In all cases, blood counts, C-reactive protein (CRP) levels, and procalcitonin (PCT) levels were recorded...
March 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28438138/accuracy-of-serum-procalcitonin-for-the-diagnosis-of-sepsis-in-neonates-and-children-with-systemic-inflammatory-syndrome-a-meta-analysis
#18
Giuseppe Pontrelli, Franco De Crescenzo, Roberto Buzzetti, Alessandro Jenkner, Sara Balduzzi, Francesca Calò Carducci, Donato Amodio, Maia De Luca, Sara Chiurchiù, Elin Haf Davies, Giorgia Copponi, Alessandra Simonetti, Elena Ferretti, Valeria Di Franco, Virginia Rasi, Martina Della Corte, Luca Gramatica, Marco Ciabattini, Susanna Livadiotti, Paolo Rossi
BACKGROUND: A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis of sepsis in adults and showed to be promising in paediatrics. Our study reviewed the diagnostic accuracy of PCT as an early biomarker of sepsis in neonates and children with suspected sepsis. METHODS: A comprehensive literature search was carried out in Medline/Pubmed, Embase, ISI Web of Science, CINAHL and Cochrane Library, for studies assessing PCT accuracy in the diagnosis of sepsis in children and neonates with suspected sepsis...
April 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28432884/use-of-presepsin-and-procalcitonin-for-prediction-of-septifast-results-in-critically-ill-patients
#19
Dunja Mihajlovic, Snezana Brkic, Arsen Uvelin, Biljana Draskovic, Vladimir Vrsajkov
PURPOSE: There is a need for identification of marker that could lead physicians to take the right step towards laboratory techniques for documentation of infection. The aim of this study was to investigate whether presepsin and procalcitonin (PCT) levels in patients with suspected sepsis could predict blood culture (BC) and SeptiFast (SF) results. MATERIAL AND METHODS: 100 patients were included in our study. PCT, C-reactive protein (CRP), and presepsin levels were determined...
April 8, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28427289/biomarkers-for-diagnosis-of-neonatal-sepsis-a-literature-review
#20
Deepak Sharma, Nazanin Farahbakhsh, Sweta Shastri, Pradeep Sharma
Sepsis is an important cause of mortality and morbidity in neonatal populations. There has been constant search of an ideal sepsis biomarker that have high sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), so that both the diagnosis and exclusion of neonatal sepsis can be made at the earliest possible and appropriate antibiotics can be started to neonate. Ideal sepsis biomarker will help in guiding us when not to start antibiotics in case of suspect sepsis and total duration of antibiotics course in case of proven sepsis...
May 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
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