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procalcitonin sepsis

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https://www.readbyqxmd.com/read/29768131/a-new-scoring-system-to-predict-blood-stream-infections-in-patients-with-complicated-intra-abdominal-infections-experience-from-a-tertiary-referral-hospital-in-china
#1
Jinjian Huang, Jianan Ren, Luise Brakert, Jiao Jiao, Qinjie Liu, Gefei Wang, Xiuwen Wu, Steven W M Olde Damink
BACKGROUND: This purpose of this study was to investigate the effects of blood stream infections (BSIs) on the prognosis of patients with complicated intra-abdominal infections (IAIs) and to make predictions based on patients' characteristics on admission. PATIENTS AND METHODS: One hundred eighty-seven patients with complicated IAI in 2014 and 2015 were included in our retrospective analysis, except for those diagnosed with central line-associated blood stream infections (CLABSIs)...
May 2018: Surgical Infections
https://www.readbyqxmd.com/read/29760745/diagnostic-value-of-decoy-receptor-3-combined-with-procalcitonin-and-soluble-urokinase-type-plasminogen-activator-receptor-for-sepsis
#2
Jing-Jing Zhao, Xiao-Li Lou, Hong-Wei Chen, Feng-Ting Zhu, Yan-Qiang Hou
The levels of decoy receptor 3 (DcR3), soluble urokinase type plasminogen activator receptor (suPAR) and procalcitonin (PCT) are significantly increased in sepsis. We investigated the diagnostic value of DcR3 combined with suPAR and PCT in sepsis. Patients with sepsis, non-infectious systemic inflammatory response comprehensive syndrome (SIRS) and healthy controls were recruited according to the diagnostic standard. We measured DcR3, suPAR, PCT, interleukin-6 (IL-6) and C-reactive protein (CRP), and the diagnostic value was evaluated by receiver operating characteristics (ROC) curves...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29753321/influence-of-pathogen-and-focus-of-infection-on-procalcitonin-values-in-sepsis-patients-with-bacteremia-or-candidemia
#3
Daniel O Thomas-Rüddel, Bernhard Poidinger, Matthias Kott, Manfred Weiss, Konrad Reinhart, Frank Bloos
BACKGROUND: This study aimed to evaluate the accuracy of procalcitonin (PCT) serum concentrations to diagnose Gram-negative bacteremia and the association of PCT serum concentrations with more specific pathogens and the focus of infection. METHODS: Secondary analysis of the prospectively collected patient-level dataset from a cluster randomized quality improvement trial was performed. The trial included sepsis patients with organ dysfunction treated in the participating intensive care units from 2011 to 2015...
May 13, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29742943/comparison-between-presepsin-and-procalcitonin-in-early-diagnosis-of-neonatal-sepsis
#4
Agustin Iskandar, Maimun Z Arthamin, Kristin Indriana, Muhammad Anshory, Mina Hur, Salvatore Di Somma
BACKGROUND: Neonatal sepsis remains worldwide one of the leading causes of morbidity and mortality in both term and preterm infants. Lower mortality rates are related to timely diagnostic evaluation and prompt initiation of empiric antibiotic therapy. Blood culture, as gold standard examination for sepsis, has several limitations for early diagnosis, so that sepsis biomarkers could play an important role in this regard. This study was aimed to compare the value of the two biomarkers presepsin and procalcitonin in early diagnosis of neonatal sepsis...
May 9, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29742588/derivation-and-validation-of-a-biomarker-based-clinical-algorithm-to-rule-out-sepsis-from-noninfectious-systemic-inflammatory-response-syndrome-at-emergency-department-admission-a-multicenter-prospective-study
#5
Filippo Mearelli, Nicola Fiotti, Carlo Giansante, Chiara Casarsa, Daniele Orso, Marco De Helmersen, Nicola Altamura, Maurizio Ruscio, Luigi Mario Castello, Efrem Colonetti, Rossella Marino, Giulia Barbati, Andrea Bregnocchi, Claudio Ronco, Enrico Lupia, Giuseppe Montrucchio, Maria Lorenza Muiesan, Salvatore Di Somma, Gian Carlo Avanzi, Gianni Biolo
OBJECTIVES: To derive and validate a predictive algorithm integrating a nomogram-based prediction of the pretest probability of infection with a panel of serum biomarkers, which could robustly differentiate sepsis/septic shock from noninfectious systemic inflammatory response syndrome. DESIGN: Multicenter prospective study. SETTING: At emergency department admission in five University hospitals. PATIENTS: Nine-hundred forty-seven adults in inception cohort and 185 adults in validation cohort...
May 7, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29739069/association-between-vitamin-d-status-and-sepsis
#6
Wei Zhou, Song Mao, Liangxia Wu, Jun Yu
BACKGROUND: It is well-established that vitamin D status is closely associated with the susceptibility to infections. We aimed to study the association between vitamin D status and sepsis risk and death, and also analyzed the correlation between vitamin D level and sepsis-related factors. METHODS: We searched the articles regarding the association between vitamin D level and sepsis through May 2017 in electronic databases. We pooled the data and analyzed the association between vitamin D level and sepsis risk, death, and albumin (ALB), mortality, body mass index (BMI), procalcitonin (PCT), male/female ratio, interleukin-6 (IL-6), platelet (PLT), c-reactive protein (CRP) and white blood cell (WBC)...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29731821/clinical-significance-of-the-detection-of-procalcitonin-and-c-reactive-protein-in-the-intensive-care-unit
#7
Qinhao Li, Xiaona Gong
The identification significance of C-reactive protein (CRP) and procalcitonin (PCT) levels in the intensive care unit patients with combined infection and their prognostic effects of patients with sepsis was investigated. A total of 203 patients were divided into the sepsis (n=60) and the non-sepsis group (n=143). The predictive effects of CRP and PCT levels in patients in the intensive care unit on sepsis and their effects on the prognosis of patients with sepsis were analyzed. The results showed that CRP and PCT levels in patients in the sepsis were higher than those in the non-sepsis group (P<0...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29725382/effects-of-cisatracurium-in-combination-with-ventilation-on-inflammatory-factors-and-immune-variations-in-sepsis-rats
#8
Tongyun He, Jianmei Tao, Xinqiang Wang, Xuena Wang
The effects of cisatracurium in combination with ventilation on inflammatory factors and immune variations in sepsis rats were investigated. A total of 54 male Sprague-Dawley rats were selected and divided randomly into three groups: Sham group (n=6), model group (n=24) and experiment group (n=24). Rats in the model and experiment groups underwent cecal ligation and puncture (CLP) for establishment of sepsis model. Rats in experiment group additionally received cisatracurium medication in combination with ventilation for treatment...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29721246/acute-encephalopathy-with-biphasic-seizures-and-late-reduced-diffusion-associated-with-streptococcus-sanguinis-sepsis
#9
Hitoshi Awaguni, Jun Shinozuka, Shin-Ichiro Tanaka, Sayaka Kadowaki, Shigeru Makino, Rikken Maruyama, Yosuke Shigematsu, Kenji Hamaoka, Shinsaku Imashuku
Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) develops in association with systemic as well as central nervous system (CNS) viral or bacterial infections. AESD is most often noted with influenza or human herpesvirus 6 infection in previously healthy infants. However, AESD has also been reported in an infant with developmental retardation and in a mentally and motor-disabled adolescent. Here, we report the case of a 4- year-old female with significant development delay due to spinal muscular atrophy, who developed AESD during Streptococcus sanguinis sepsis with no apparent CNS infection...
March 22, 2018: Pediatric Reports
https://www.readbyqxmd.com/read/29717808/how-should-procalcitonin-and-c-reactive-protein-levels-be-interpreted-in-hemodialysis-patients
#10
Nazlim Aktug Demir, Sua Sumer, Gulperi Celik, Rengin Elsurer Afsar, Lutfi Saltuk Demir, Onur Ural
BACKGROUND: Procalcitonin (PCT) and C-reactive protein (CRP) are used most widely in the diagnosis/treatment of bacterial infections. These are not infection-specific and may also show increases in other inflammation-causing cases. AIMS: We aimed to establish a new cut off value for PCT and CRP to eliminate confusion in the diagnosis and treatment of bacterial infections in hemodialysis (HD) patients. METHODS: A total of 1110 patients, 802 with undocumented infection and 308 with documented infection, were included in the study...
May 2, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29707313/expression-pattern-of-soluble-triggering-receptor-expressed-on-myeloid-cells-1-in-mice-with-acinetobacter-baumannii-colonization-and-infection-in-the-lung
#11
Chengping Hu, Juan Jiang, Zhen Li, Yuanyuan Li
Background: Acinetobacter baumannii ( A. baumannii ) is one of the most troublesome opportunistic pathogens associated with hospital-acquired pneumonia (HAP). It is important to be able to discriminate A. baumannii colonization from infection in its early stages so that effective antibiotics can be promptly applied. Recent studies have reported that the secretion of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is markedly upregulated in pneumonia and sepsis, but the expression pattern of sTREM-1 in A...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29706801/lactate-as-a-potential-biomarker-of-sepsis-in-a-rat-cecal-ligation-and-puncture-model
#12
Xiaozhu Zhai, Zhengfei Yang, Guanghui Zheng, Tao Yu, Peng Wang, Xuefen Liu, Qin Ling, Longyuan Jiang, Wanchun Tang
We attempted to investigate whether blood lactate is a useful biomarker for sepsis in a rat cecal ligation and puncture (CLP) model. Male Sprague-Dawley rats underwent approximately 75% cecum ligation and two punctures to induce high-grade sepsis. A lactate of 1.64 mmol/L (Youden score of 0.722) was selected as the best cutoff value to predict the onset of sepsis after CLP exposure; 46 of 50 rats who survived 24 hours after the CLP were divided into the L group (lactate < 1.64 mmol/L) and M group (lactate ≥ 1...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29705804/removal-of-procalcitonin-and-selected-cytokines-during-continuous-veno-venous-hemodialysis-using-high-cutoff-hemofilters-in-patients-with-sepsis-and-acute-kidney-injury
#13
Grzegorz Kade, Sławomir Literacki, Agnieszka Rzeszotarska, Stanisław Niemczyk, Arkadiusz Lubas
INTRODUCTION: The purpose of this study was to evaluate the impact of continuous veno-venous hemodialysis (CVVHD) using high cutoff (HCO) hemofilters on the removal of procalcitonin (PCT), and other inflammatory markers in the treatment of patients during septic shock with acute kidney injury (AKI). MATERIALS AND METHODS: Thirty-six patients with septic shock and AKI were included in the study. Before and after the 24-h HCO-CVVHD, PCT, native C-reactive protein (CRP) and cytokines (interleukin-1β, interleukin-6, interleukin-12, interleukin-17, tumor necrosis factor-α) in serum and effluent were assessed...
April 27, 2018: Blood Purification
https://www.readbyqxmd.com/read/29704446/decreased-protein-c-function-predicts-mortality-in-patients-with-cirrhosis
#14
A G Patil, C Bihari, H D Shewade, N Nigam, S K Sarin
INTRODUCTION: Protein C (PrC), a physiological anticoagulant, regulates inflammation and cell death and has known predictive/therapeutic roles in sepsis. Accumulating evidences suggest plasma hypercoagulability results in progression of fibrosis and formation of microclots causing end-organ dysfunction. We investigated a possible association between natural anticoagulants-PrC, protein S (PrS) and antithrombin III (AT)-and clinical outcomes in cirrhotics. METHODS: Functional PrC, PrS and AT were analysed in 515 cirrhotic patients and compared with 229 noncirrhotics...
April 28, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29682292/plasma-procalcitonin-concentrations-are-increased-in-dogs-with-sepsis
#15
Robert Goggs, Matthew Milloway, Roberta Troia, Massimo Giunti
Sepsis, the life-threatening organ dysfunction caused by a dysregulated host response to infection, is difficult to identify and to prognosticate for. In people with sepsis, procalcitonin (PCT) measurement aids diagnosis, enables therapeutic monitoring and improves prognostic accuracy. This study used a commercial canine PCT assay to measure plasma PCT concentrations in dogs with gastric dilatation volvulus (GDV) syndrome and in dogs with sepsis. It was hypothesised that dogs with GDV syndrome and with sepsis have greater plasma PCT concentrations than healthy dogs and that dogs with sepsis have greater PCT concentrations than dogs with GDV syndrome...
2018: Veterinary Record Open
https://www.readbyqxmd.com/read/29680395/plasma-procalcitonin-concentration-in-healthy-calves-and-those-with-septic-systemic-inflammatory-response-syndrome
#16
F Bonelli, V Meucci, T J Divers, A Boccardo, D Pravettoni, M Meylan, A G Belloli, M Sgorbini
The diagnosis of sepsis in calves is challenging. Blood culture and clinical signs combined with a complete blood count have been used for the diagnosis of sepsis. Recent literature in humans and animal species has been focused on sepsis-specific biomarkers, such as procalcitonin (PCT), that may more accurately and efficiently diagnose sepsis. The aim of this study was to evaluate plasma PCT concentrations in healthy and septic calves. Twenty healthy control calves and 58 sick calves with septic systemic inflammatory response syndrome (SIRS) based on SIRS score and clinical findings were included...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29668936/biomarkers-of-sepsis-and-bloodstream-infections-the-role-of-procalcitonin-and-proadrenomedullin-with-emphasis-in-patients-with-cancer
#17
Hanine El Haddad, Anne-Marie Chaftari, Ray Hachem, Patrick Chaftari, Issam I Raad
Sepsis and bloodstream infections remain a leading cause of death in immunocompromised cancer patients. The management of these serious infections consist of empiric use of antimicrobial agents which are often overused. Procalcitonin and proadrenomedullin are biomarkers that have been extensively evaluated in the general populations with little emphasis in the immunocompromised cancer patient population where they may have promising roles in the management of febrile patients. In this review, we summarize the available evidence of the potential role of these available biomarkers in guiding antimicrobial therapy to optimize resource utilization in the general patient population...
April 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29667377/the-usefulness-of-determination-of-the-procalcitonin-pct-concentration-in-gbs-piositive-pregnant-womens-blood-serum-for-anticipations-of-infections-in-newborns
#18
Wojciech Cnota, Dominika Mucha, Jan Mucha
Group-B streptococci (GBS) are commensal bacteria of the human body. They may, however, pose a serious life hazard to pregnant women. During labour, newborns of GBS-positive mothers run the risk of infections that may eventually lead to severe complications, sepsis or even death. For this reason, it is very important to find new diagnostic markers that will enable fast and effective diagnostics and control of the disease process. The level of procalcitonin emerges as a promising diagnostic parameter. AIM. Analysis of the impact of the procalcitonin (PCT) level in GBS-positive pregnant women on the possibility of complications and infections in mothers and newborns MATERIAL AND METHODS...
2018: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29667256/procalcitonin-and-c-reactive-protein-as-biomarkers-for-neonatal-bacterial-infection
#19
Ashfaque F Quadir, Philip N Britton
AIM: Neonates are predisposed to bacterial infection which are an important cause of early childhood morbidity and mortality globally. It has been proposed that procalcitonin has significant utility as a diagnostic marker for bacterial infection in febrile neonates when compared to C-reactive protein (CRP). The aim of this study is to conduct a literature search to find the best available evidence to answer the clinical question of the utility of procalcitonin when compared to CRP as a predictor of bacterial infection in febrile neonates...
April 17, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29663997/-predictive-value-of-inflammatory-markers-for-acute-kidney-injury-in-sepsis-patients-analysis-of-753-cases-in-7-years
#20
Xiao Zhou, Jingfeng Liu, Xiaojun Ji, Xiaowei Yang, Meili Duan
OBJECTIVE: To evaluate different inflammation markers for predicting the risk of acute kidney injury (AKI) in sepsis patients. METHODS: A retrospective observational study was conducted. The adult patients with sepsis for more than 24 hours admitted to intensive care unit (ICU) of Beijing Friendship Hospital, Capital Medical University from March 1st, 2010 to November 1st, 2017 were enrolled. Inflammatory markers such as white blood cell count (WBC), erythrocyte sedimentation rata (ESR), neutrophil and lymphocyte ratio (NLR), C-reactive protein (CRP), procalcitonin (PCT), etc...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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