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https://www.readbyqxmd.com/read/29245111/community-based-rehabilitation-offers-cost-effective-epilepsy-treatment-in-rural-guinea-bissau
#1
Eric van Diessen, Frank van der Maas, Vladimir Cabral, Willem M Otte
Treatment of epilepsy in low-income countries is a challenge considering the lack of resources, availability of antiepileptic drugs, and cultural beliefs. We used a community-based rehabilitation (CBR) service for the detection, monitoring, and treatment of epilepsy. A local network of trained community volunteers provided education, good quality antiepileptic drugs, and clinical follow-up for people with epilepsy (PWE). In a period of 2years, approximately 22,500 people were screened in central Guinea-Bissau, and 112 PWE were identified and registered...
December 12, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29244860/lithium-reduces-blood-glucose-levels-but-aggravates-albuminuria-in-btbr-ob-ob-mice
#2
Theun de Groot, Lars Damen, Leanne Kosse, Mohammad Alsady, Rosalinda Doty, Ruben Baumgarten, Susan Sheehan, Johan van der Vlag, Ron Korstanje, Peter M T Deen
Glycogen synthase kinase 3 (GSK3) plays an important role in the development of diabetes mellitus and renal injury. GSK3 inhibition increases glucose uptake in insulin-insensitive muscle and adipose tissue, while it reduces albuminuria and glomerulosclerosis in acute kidney injury. The effect of chronic GSK3 inhibition in diabetic nephropathy is not known. We tested the effect of lithium, the only clinical GSK3 inhibitor, on the development of diabetes mellitus and kidney injury in a mouse model of diabetic nephropathy...
2017: PloS One
https://www.readbyqxmd.com/read/29244802/elevations-of-inflammatory-proteins-in-neonatal-blood-are-associated-with-obesity-and-overweight-among-2-year-old-children-born-extremely-premature
#3
Eliana M Perrin, T Michael O'Shea, Asheley Cockrell Skinner, Carl Bose, Elizabeth N Allred, Raina N Fichorova, Jelske W van der Burg, Alan Leviton
BACKGROUND: Childhood obesity is associated with elevated blood concentrations of inflammation markers. It is not known to what extent inflammation precedes the development of obesity. METHODS: In a cohort of 882 infants born before 28 weeks of gestation, we examined relationships between concentrations of 25 inflammation-related proteins in blood obtained during the first two postnatal weeks and body mass index at 2 years of age. RESULTS: Among children delivered for spontaneous indications (n=734), obesity was associated with elevated concentrations of four proteins (IL-1β, IL-6, TNF-R1, and MCP-1) on the first postnatal day; one protein (IL-6) on postnatal day 7; and two proteins (ICAM-3 and VEGF-R1) on postnatal day 14...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244611/learning-new-letter-like-writing-patterns-explicitly-and-implicitly-in-children-and-adults
#4
M Jongbloed-Pereboom, A Overvelde, M W G Nijhuis-van der Sanden, B Steenbergen
A handwriting task was used to test the assumption that explicit learning is dependent on age and working memory, while implicit learning is not. The effect of age was examined by testing both, typically developing children (5-12 years old, n = 81) and adults (n = 27) in a counterbalanced within-subjects design. Participants were asked to repeatedly write letter-like patterns on a digitizer with a non-inking pen. Reproduction of the pattern was better after explicit learning compared to implicit learning. Age had positive effects on both explicit and implicit learning; working memory did not affect learning in either conditions...
December 15, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/29244153/cohort-profile-the-hoorn-studies
#5
Femke Rutters, Giel Nijpels, Petra Elders, Coen D A Stehouwer, Amber A van der Heijden, Lenka Groeneveld, Leen M 't Hart, Jacqueline M Dekker, Joline W J Beulens
No abstract text is available yet for this article.
December 13, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29244062/longitudinal-course-and-predictors-of-apathetic-symptoms-after-severe-traumatic-brain-injury
#6
Annabelle Arnould, Lucien Rochat, Philippe Azouvi, Martial Van der Linden
Objectives: Apathy is one of the most common behavioral symptoms encountered after traumatic brain injury (TBI). However, very little is known about the longitudinal course and predictors of apathetic manifestations. The aims of the present study were to examine how apathy changes and the predictive value of cognitive factors (memory, attention/executive mechanisms, and multitasking) and personal identity factors (self-esteem and self-efficacy beliefs) for apathy over a period of 10 months...
December 13, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29243930/structure-based-kinase-profiling-to-understand-the-polypharmacological-behavior-of-therapeutic-molecules
#7
Devawati Dutta, Ranjita Das, Chhabinath Mandal, Chitra Mandal
Several drugs elicit their therapeutic efficacy by modulating multiple cellular targets and possess varied polypharmacological actions. The identification of the molecular targets of a potent bioactive molecule is essential in determining its overall polypharmacological profile. Experimental procedures are expensive and time-consuming. Therefore, computational approaches are actively implemented in rational drug discovery. Here, we demonstrate a computational pipeline, based on reverse virtual screening technique using several consensus scoring strategies, and perform structure-based kinase profiling of 12 FDA-approved drugs...
December 15, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29243874/emotional-and-behavioral-problems-in-children-and-adolescents-with-neurofibromatosis-type-1
#8
André B Rietman, Thijs van der Vaart, Ellen Plasschaert, Bethany A Nicholson, Rianne Oostenbrink, Lianne C Krab, Mie-Jef Descheemaeker, Marie-Claire Y de Wit, Henriëtte A Moll, Eric Legius, Pieter F A de Nijs
To assess emotional and behavioral problems in children and adolescents with neurofibromatosis type 1,parents of 183 individuals aged 10.8 ± 3.1 years (range 6-17) completed the Child Behavior Checklist (CBCL). Also, 173 teachers completed the Teacher's Report Form (TRF), and 88 adolescents (children from 11 to 17 years) completed the Youth Self-Report (YSR). According to parental ratings, 32% scored in the clinical range (above the 90th percentile). This percentage was much lower when rated by teachers or adolescents themselves...
December 15, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29243146/correction-to-contraception-menstruation-and-sexuality-after-bariatric-surgery-a-prospective-cohort-study
#9
Julie Luyssen, Goele Jans, Annick Bogaerts, Dries Ceulemans, Christophe Matthys, Bart Van der Schueren, Matthias Lannoo, Johan Verhaeghe, Luc Lemmens, Lore Lannoo, Jill Shawe, Roland Devlieger
The spelling of author name Jill Shawe was incorrect in the original article. It is correct here.
December 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29243048/spectroscopic-evidence-of-phosphorous-heterocycle-dna-interaction-and-its-verification-by-docking-approach
#10
Swarup Roy, Shailendra K Saxena, Suryakant Mishra, Priyanka Yogi, P R Sagdeo, Rajesh Kumar
In the present work, the interaction of phosphorous heterocycle (PH) with calf thymus DNA (CTDNA) has been studied using spectroscopy and verified by molecular modeling which is found to be in consonance with each other. Apparent association constant (Kapp = 4.77 × 103 M- 1), calculated using UV-Vis spectra indicating an adequate complex formation between CTDNA and PH. A dynamic mode of the fluorescence quenching mechanism in case of ethidium bromide (EB) + CTDNA by PH has been observed confirming formation of DNA-PH complex...
December 14, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/29242781/ima-genome-f-8-draft-genome-of-cercospora-zeina-fusarium-pininemorale-hawksworthiomyces-lignivorus-huntiella-decipiens-and-ophiostoma-ips
#11
Brenda D Wingfield, Dave K Berger, Emma T Steenkamp, Hye-Jin Lim, Tuan A Duong, Burton H Bluhm, Z Wilhelm de Beer, Lieschen De Vos, G Fourie, Kershney Naidoo, Nicky Olivier, Yao-Cheng Lin, Yves Van de Peer, Fourie Joubert, Bridget G Crampton, Velushka Swart, Nicole Soal, Catherine Tatham, Magriet A van der Nest, Nicolaas A van der Merwe, Stephanie van Wyk, P Markus Wilken, Michael J Wingfield
The genomes of Cercospora zeina, Fusarium pininemorale, Hawksworthiomyces lignivorus, Huntiella decipiens, and Ophiostoma ips are presented in this genome announcement. Three of these genomes are from plant pathogens and otherwise economically important fungal species. Fusarium pininemorale and H. decipiens are not known to cause significant disease but are closely related to species of economic importance. The genome sizes range from 25.99 Mb in the case of O. ips to 4.82 Mb for H. lignivorus. These genomes include the first reports of a genome from the genus Hawksworthiomyces...
December 2017: IMA Fungus
https://www.readbyqxmd.com/read/29242526/percentiles-for-skeletal-muscle-index-area-and-radiation-attenuation-based-on-computed-tomography-imaging-in-a-healthy-caucasian-population
#12
A van der Werf, J A E Langius, M A E de van der Schueren, S A Nurmohamed, K A M I van der Pant, S Blauwhoff-Buskermolen, N J Wierdsma
BACKGROUND/OBJECTIVES: Muscle mass is a key determinant of nutritional status and associated with outcomes in several patient groups. Computed tomography (CT) analysis is increasingly used to assess skeletal muscle area (SMA), skeletal muscle index (SMI) and muscle radiation attenuation (MRA). However, interpretation of these muscle parameters is difficult since values in a healthy population are lacking. The aim of this study was to provide sex specific percentiles for SMA, SMA and MRA in a healthy Caucasian population and to examine the association with age and BMI in order to define age- and BMI specific percentiles...
December 15, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29242508/variations-in-cochlear-duct-shape-revealed-on-clinical-ct-images-with-an-automatic-tracing-method
#13
Annerie M A van der Jagt, Randy K Kalkman, Jeroen J Briaire, Berit M Verbist, Johan H M Frijns
Cochlear size and morphology vary greatly and may influence the course of a cochlear implant electrode array during insertion and its final intra-cochlear position. Detailed insight into these variations is valuable for characterizing each cochlea and offers the opportunity to study possible correlations with surgical or speech perception outcomes. This study presents an automatic tracing method to assess individual cochlear duct shapes from clinical CT images. On pre-operative CT scans of 479 inner ears the cochlear walls were discriminated by interpolating voxel intensities along radial and perpendicular lines within multiplanar reconstructions at 1 degree intervals from the round window...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29242173/exploring-determinants-of-patient-adherence-to-a-portal-supported-oncology-rehabilitation-program-interview-and-data-log-analyses
#14
Hendrik P Buimer, Monique Tabak, Lex van Velsen, Thea van der Geest, Hermie Hermens
BACKGROUND: Telemedicine applications often do not live up to their expectations and often fail once they have reached the operational phase. OBJECTIVE: The objective of this study was to explore the determinants of patient adherence to a blended care rehabilitation program, which includes a Web portal, from a patient's perspective. METHODS: Patients were enrolled in a 12-week oncology rehabilitation treatment supported by a Web portal that was developed in cooperation with patients and care professionals...
December 14, 2017: JMIR Rehabilitation and Assistive Technologies
https://www.readbyqxmd.com/read/29241940/plant-soil-feedback-bridging-natural-and-agricultural-sciences
#15
REVIEW
Pierre Mariotte, Zia Mehrabi, T Martijn Bezemer, Gerlinde B De Deyn, Andrew Kulmatiski, Barbara Drigo, G F Ciska Veen, Marcel G A van der Heijden, Paul Kardol
In agricultural and natural systems researchers have demonstrated large effects of plant-soil feedback (PSF) on plant growth. However, the concepts and approaches used in these two types of systems have developed, for the most part, independently. Here, we present a conceptual framework that integrates knowledge and approaches from these two contrasting systems. We use this integrated framework to demonstrate (i) how knowledge from complex natural systems can be used to increase agricultural resource-use efficiency and productivity and (ii) how research in agricultural systems can be used to test hypotheses and approaches developed in natural systems...
December 11, 2017: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/29241468/-addendum-to-the-dutch-guideline-for-minor-head-brain-injury
#16
C L van den Brand, J van der Naalt, G Hageman, H P Bienfait, R A van der Kruijk, K Jellema
- After introduction of the Dutch guideline for 'Care for patients with minor head/brain injury' (LTH guideline) in 2010, the number of CT scans has increased. Some of these scans were for patients with only trivial trauma and may not have been necessary.- In addition, since this guideline was implemented, there have been changes in the use of anticoagulants and platelet aggregation inhibitors. Non-vitamin-K-dependent oral anticoagulants (NOACs) and platelet aggregation inhibitors, or combinations of these, are prescribed more often...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29241465/-delayed-umbilical-cord-separation
#17
H Theeuwen, J van der Sluijs, M Nanlohy-Manuhutu
We present the case report of a preterm infant with delayed umbilical cord separation. At the age of four weeks the umbilical cord separation had still not occurred. The umbilical cord tissue sometimes seemed wet and did not dry completely. There were no signs of immunodeficiency. An ultrasound of the abdomen showed a small urachal cyst. No further intervention was indicated.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29241464/-diagnostic-approach-and-treatment-of-primary-hyperparathyroidism
#18
W Y van der Plas, M E Noltes, A W M A Schaeffers, A H Brouwers, A N A van der Horst-Schrivers, S Kruijff
- Primary hyperparathyroidism (PHPT) is characterised by elevated serum calcium levels due to elevated levels, or insufficient suppression, of parathyroid hormone (PTH).- The incidence of PHPT has increased in recent years. This is mainly the result of more frequently performed routine measurements of serum calcium, e.g. as part of postmenopausal screening.- The classically described features of PHPT - bones and stones - are not always observed and most patients are asymptomatic.- Diagnosis of PHPT is only established by biochemical testing, not by imaging...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29241283/-there-is-no-season-for-gifts
#19
Klaus Lieb, Cora Koch
Gifts and payments from pharmaceutical manufacturers to medical doctors constitute a conflict of interest, which may lead to an undue influence on prescribing behavior. In Germany, 35 research-based pharmaceutical companies, organized in the "Verband der forschenden Arzneimittelhersteller (VfA)" paid € 562 million to medical doctors and hospitals in 2016. Of these, € 356 million were paid for clinical trials and non-interventional studies, € 105 million for sponsored presentations and CME and € 101 million went to hospitals and other organizations for sponsoring, consulting and events...
December 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29241259/-competence-based-catalogue-of-learning-objectives-for-rehabilitation-physical-medicine-naturopathic-treatment-revised-version-joint-recommendations-of-the-german-society-of-rehabilitation-science-and-the-german-society-of-physical-medicine-and-rehabilitation
#20
Wilfried Mau, Max Emanuel Liebl, Ruth Deck, Uwe Lange, Ulrich Christian Smolenski, Susanne Walter, Christoph Gutenbrunner
Since the first publication of learning objectives for the interdisciplinary subject "Rehabilitation, Physical Medicine, Naturopathic Treatment" in undergraduate medical education in 2004 a revision is reasonable due to heterogenous teaching programmes in the faculties and the introduction of the National Competence Based Catalogue of Learning Objectives in Medicine as well as the "Masterplan Medical Education 2020". Therefore the German Society of Rehabilitation Science and the German Society of Physical Medicine and Rehabilitation started a structured consensus process using the DELPHI-method to reduce the learning objectives and arrange them more clearly...
December 2017: Die Rehabilitation
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