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https://www.readbyqxmd.com/read/28823011/guidelines-versus-reality-is-coronary-stent-application-in-three-vessel-disease-standard-or-the-exception
#1
Roland Linder, J Zeidler, F Verheyen, J-M Graf von der Schulenburg, A Haverich, T Schilling
The national guidelines for treatment of chronic coronary heart disease (CHD) recommend surgical coronary aortic bypass grafting (CABG) rather than percutaneous coronary intervention (PCI) for patients with a coronary three-vessel disease. The epidemiology of three-vessel CHD and data about the application of different revascularisation strategies raise suspicion of deviation from the guidelines in the treatment of those patients. Claims data containing records of almost 10 million patients of the largest German statutory health insurance fund (Techniker Krankenkasse) were utilised to measure adherence to the guidelines for treatment of groups of patients with one-, two-, and three-vessel CHD, respectively...
August 19, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28822976/persistence-after-treatment-of-pharyngeal-gonococcal-infections-in-patients-of-the-sti-clinic-amsterdam-the-netherlands-2012-2015-a-retrospective-cohort-study
#2
I Putu Yuda Hananta, Henry John Christiaan De Vries, Alje P van Dam, Martijn Sebastiaan van Rooijen, Hardyanto Soebono, Maarten Franciscus Schim van der Loeff
INTRODUCTION: Infection of Neisseria gonorrhoeae in the pharynx (pharyngeal Ng) is associated with gonococcal transmission and development of antimicrobial resistance. We assessed proportion of and determinants for persistence after treatment of pharyngeal Ng. METHODS: At the STI clinic of Amsterdam, the Netherlands, females-at-risk and men who have sex with men are routinely screened for pharyngeal Ng using an RNA-based nucleic acid amplification test (NAAT; Aptima Combo 2)...
August 19, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28822940/effects-of-airborne-ammonium-and-nitrate-pollution-strongly-differ-in-peat-bogs-but-symbiotic-nitrogen-fixation-remains-unaffected
#3
Eva van den Elzen, Leon J L van den Berg, Bas van der Weijden, Christian Fritz, Lucy J Sheppard, Leon P M Lamers
Pristine bogs, peatlands in which vegetation is exclusively fed by rainwater (ombrotrophic), typically have a low atmospheric deposition of reactive nitrogen (N) (<0.5kgha(-1)y(-1)). An important additional N source is N2 fixation by symbiotic microorganisms (diazotrophs) in peat and mosses. Although the effects of increased total airborne N by anthropogenic emissions on bog vegetation are well documented, the important question remains how different N forms (ammonium, NH4(+), versus nitrate, NO3(-)) affect N cycling, as their relative contribution to the total load strongly varies among regions globally...
August 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28822912/a-metabolic-activity-detecting-approach-to-life-detection-restoring-a-chemostat-from-stop-feeding-using-a-rapid-bioactivity-assay
#4
Shiue-Lin Li, Ming-Der Bai, Chia-Jung Hsiao, Sheng-Shung Cheng, Kenneth H Nealson
A mediated glassy carbon electrode covered by a thin-film polyviologen was used in the present study to rapidly detect bioactivity in a mixed-culture chemostat (dominated by Clostridium sp.). With the addition of 1mM hexacyanoferrate and 9mM glucose, the current increasing rate (dI/dt) measured under a poised potential of 500mV (vs. Ag/AgCl) can be defined as the quantity of metabolic activity. In the experiment of restoring the chemostat from stop-feeding, it is suggested that when the dI/dt was >2μAmin(-1), the influent pump could be directly turned on to maintain the high dilution rate of 0...
August 9, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28822886/concurrent-spectrometry-of-annihilation-radiation-and-characteristic-gamma-rays-for-activity-assessment-of-selected-positron-emitters
#5
S G Dolley, G F Steyn, T J van Rooyen, F Szelecsényi, Z Kovács, C Vermeulen, N P van der Meulen
A method is described to determine the activity of non-pure positron emitters in a radionuclide production environment by assessing the 511keV annihilation radiation concurrently with selected γ-lines, using a single High-Purity Germanium (HPGe) detector. Liquid sources of (22)Na, (52)Fe, (52m)Mn, (61)Cu, (64)Cu, (65)Zn, (66)Ga, (68)Ga, (82)Rb, (88)Y, (89)Zr and (132)Cs were prepared specifically for this study. Acrylic absorbers surrounding the sources ensured that the emitted β(+)-particles could not escape and annihilate away from the source region...
August 1, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28822870/maternal-obesity-and-attention-related-symptoms-in-the-preterm-offspring
#6
Jelske W van der Burg, Elizabeth T Jensen, Margot van de Bor, Robert M Joseph, T Michael O'Shea, Karl Kuban, Elizabeth N Allred, Megan Scott, Scott Hunter, Stephen R Hooper, Olaf Dammann, Alan Leviton
BACKGROUND: Maternal pre-pregnancy obesity, in term-born children, is associated with an increased risk of attention problems, however this relationship has not been explored among children born extremely preterm. AIM: To estimate the risk of attention problems at age 10years in children born very preterm to overweight (i.e., body mass index (BMI) 25-29kg/m(2)) and obese (i.e., BMI≥30kg/m(2)) women relative to the risk among children born to women who were neither overweight nor obese (i...
August 17, 2017: Early Human Development
https://www.readbyqxmd.com/read/28822676/the-value-of-cone-beam-computed-tomography-in-the-detection-of-salivary-stones-prior-to-sialendoscopy
#7
E H van der Meij, K H Karagozoglu, J G A M de Visscher
This study aimed to assess the value of cone beam computed tomography (CBCT) in the detection of salivary stones in patients with signs and symptoms of salivary gland obstruction. A total of 142 major salivary glands were analysed in a cohort of 127 patients with signs and symptoms of salivary gland obstruction. CBCT scans were performed in order to determine the presence of one or more salivary stones. All glands were also investigated by sialendoscopy. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated for the submandibular gland, the parotid gland, and the whole group, based on the observers' abilities to diagnose the presence or absence of calculi in the CBCT scan using the sialendoscopy data as the gold standard...
August 16, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28822279/chemical-synthesis-of-guanosine-diphosphate-mannuronic-acid-gdp-mana-and-its-c-4-o-methyl-and-c-4-deoxy-congeners
#8
Qingju Zhang, P Lynne Howell, Herman S Overkleeft, Dmitri V Filippov, Gijsbert A van der Marel, Jeroen D C Codée
Described is the first synthesis of guanosine diphosphate mannuronic acid (GDP-ManA), the sugar donor used by algae and bacteria for the production of alginate, an anionic polysaccharide composed of β-d-mannuronic acid (ManA) and α-l-guluronic acid (GulA). Understanding the biosynthesis of these polyanionic polysaccharides on the molecular level, opens up avenues to use and modulate the biosynthesis machinery for biotechnological and therapeutic applications. The synthesis reported here delivers multi-milligram amounts of the GDP-ManA donor that can be used to study the polymerase (Alg8 in Pseudomonas aeruginosa) that generates the poly-ManA chain...
August 11, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28822097/a-38-year-old-woman-with-necrotising-cervical-lymphadenitis-due-to-histoplasma-capsulatum
#9
Esther van de Vosse, Annelies van Wengen, Wendy F van der Meide, Leo G Visser, Jaap T van Dissel
CASE PRESENTATION: We analysed a 38-year-old woman with disseminated histoplasmosis for primary immunodeficiency. Her blood showed no IFN-γ response while her peripheral blood mononuclear cells (PBMCs) did. We identified IFN-γ autoantibodies of the IgG class in her serum. CONCLUSION: IFN-γ autoantibodies leading to infections were so far mainly detected in people from Asian descent, where it was found to be associated with certain HLA types. This may be the first patient of African descent, and without the typical HLA types that predispose to this problem, that produces IFN-γ autoantibodies...
August 18, 2017: Infection
https://www.readbyqxmd.com/read/28821939/analgesic-use-in-patients-with-knee-and-or-hip-osteoarthritis-referred-to-an-outpatient-center-a-cross-sectional-study-within-the-amsterdam-osteoarthritis-cohort
#10
Jesper Knoop, Joyce van Tunen, Martin van der Esch, Leo D Roorda, Joost Dekker, Marike van der Leeden, Willem F Lems
Although analgesics are widely recommended in current guidelines, underuse and inadequate prescription of analgesics seem to result in suboptimal treatment effects in patients with knee and/or hip osteoarthritis (OA). This study aimed (i) to describe the use of analgesics; and (ii) to determine factors that are related to analgesic use in patients with knee and/or hip OA referred to an outpatient center. A cross-sectional study with data from 656 patients with knee and/or hip OA referred to an outpatient center (Amsterdam Osteoarthritis (AMS-OA) cohort) was conducted...
August 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28821918/erratum-to-quality-of-recovery-after-low-pressure-laparoscopic-donor-nephrectomy-facilitated-by-deep-neuromuscular-blockade-a-randomized-controlled-study
#11
Denise M D Özdemir-van Brunschot, Gert J Scheffer, Michel van der Jagt, Johan F Langenhuijsen, Albert Dahan, Janneke E E A Mulder, Simone Willems, Luuk B Hilbrands, Rogier Donders, Cees J H M van Laarhoven, Frank A d'Ancona, Michiel C Warlé
No abstract text is available yet for this article.
August 18, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28821908/predicting-homeless-people-s-perceived-health-after-entering-the-social-relief-system-in-the-netherlands
#12
Jorien van der Laan, Barbara van Straaten, Sandra N Boersma, Gerda Rodenburg, Dike van de Mheen, Judith R L M Wolf
OBJECTIVES: We explored whether changes in the perceived health of homeless people after entering the social relief system (SRS) in The Netherlands were predicted by housing, income, hours of work, social support, unmet care needs, arrests, physical and mental health, substance use, and experiences of autonomy, competence and relatedness, in addition to perceived health at baseline, demographics, suspected intellectual disability, the duration of homelessness and the company of children in the shelter facility...
August 18, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28821636/twenty-four-hour-rhythmicity-of-circulating-metabolites-effect-of-body-mass-and-type-2-diabetes
#13
Cheryl M Isherwood, Daan R Van der Veen, Jonathan D Johnston, Debra J Skene
Metabolic profiling of individuals with type 2 diabetes mellitus (T2DM) has previously been limited to single-time-point samples, ignoring time-of-day variation. Here, we tested our hypothesis that body mass and T2DM affect daily rhythmicity and concentrations of circulating metabolites across a 24-h day in 3 age-matched, male groups-lean, overweight/obese (OW/OB), and OW/OB with T2DM-in controlled laboratory conditions, which were not confounded by large meals. By using targeted liquid chromatography/mass spectrometry metabolomics, we quantified 130 plasma metabolites every 2 h over 24 h, and we show that average metabolite concentrations were significantly altered by increased body mass (90 of 130) and T2DM (56 of 130)...
August 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28821302/participation-of-adults-with-disorders-differences-of-sex-development-dsd-in-the-clinical-study-dsd-life-design-methodology-recruitment-data-quality-and-study-population
#14
Robert Röhle, Katharina Gehrmann, Maria Szarras-Czapnik, Hedi Claahsen-van der Grinten, Catherine Pienkowski, Claire Bouvattier, Peggy Cohen-Kettenis, Anna Nordenström, Ute Thyen, Birgit Köhler
BACKGROUND: dsd-LIFE is a comprehensive cross-sectional clinical outcome study of individuals with disorders/differences of sex development (DSD). This study focuses on various rare genetic conditions characterized by impaired gonadal or adrenal functionality. METHODS/DESIGN: The study aims to assess quality of life (QoL) as a measure of psychosocial adaptation, psychosexual and mental health aspects as major outcomes. Health status and functioning, medical and surgical therapies, participants' views on health care, psychological and social support, sociodemographic factors and their interrelations will be investigated as factors associated with the outcomes...
August 18, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28821284/physical-exercise-following-esophageal-cancer-treatment-perfect-study-design-of-a-randomized-controlled-trial
#15
Jonna K van Vulpen, Peter D Siersema, Richard van Hillegersberg, Grard A P Nieuwenhuijzen, Ewout A Kouwenhoven, Richard P R Groenendijk, Donald L van der Peet, Eric J Hazebroek, Camiel Rosman, Carlo C G Schippers, Elles Steenhagen, Petra H M Peeters, Anne M May
BACKGROUND: Following esophagectomy, esophageal cancer patients experience a clinically relevant deterioration of health-related quality of life, both on the short- and long-term. With the currently growing number of esophageal cancer survivors, the burden of disease- and treatment-related complaints and symptoms becomes more relevant. This emphasizes the need for interventions aimed at improving quality of life. Beneficial effects of post-operative physical exercise have been reported in several cancer types, but so far comparable evidence in esophageal cancer patients is lacking...
August 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28821085/dissolution-mechanism-of-cellulose-in-quaternary-ammonium-hydroxide-revisiting-through-molecular-interactions
#16
Chao Zhong, Fang Cheng, Yingkui Zhu, Zhen Gao, Honghua Jia, Ping Wei
Quaternary ammonium hydroxide (QAH) solution has been used to dissolve cellulose and made great progress in recent years. While, its cellulose dissolution mechanism is still in unclear. Here, series of QAH with varied cationic alkyl chains were chosen for the investigation. The solubility of cellulose in QAH was measured, which allowed us to study the effect of cationic structure on cellulose dissolution. Also, the Kamlet-Taft parameters as well as 1D and 2D NMR analyses of QAH-cellulose/cellobiose system were measured...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820946/proteogenomic-investigation-of-strain-variation-in-clinical-mycobacterium-tuberculosis-isolates
#17
Tiaan Heunis, Anzaan Dippenaar, Robin M Warren, Paul D van Helden, Ruben G van der Merwe, Nicolaas C Gey van Pittius, Arnab Pain, Samantha L Sampson, David L Tabb
Mycobacterium tuberculosis consists of a large number of different strains that display unique virulence characteristics. Whole-genome sequencing has revealed substantial genetic diversity among clinical M. tuberculosis isolates, and elucidating the phenotypic variation encoded by this genetic diversity will be of utmost importance to fully understand M. tuberculosis biology and pathogenicity. In this study we integrated whole-genome sequencing and mass spectrometry (GeLC-MS/MS) to reveal strain-specific characteristics in the proteomes of two clinical M...
August 18, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28820830/discussion-on-intraoperative-comparison-of-anatomical-versus-round-implants-in-breast-augmentation-a-randomized-controlled-trial-plast-reconstruct-surg-139-587-2017
#18
Lesley R Bouwer, Hieronymus P Stevens, Berend van der Lei
No abstract text is available yet for this article.
August 10, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28820750/the-new-realization-about-cribriform-prostate-cancer
#19
Kenneth A Iczkowski, Gladell P Paner, Theodorus Van der Kwast
Data from the past 6 years have shown that the presence of any amount of cribriform (or more comprehensively, large acinar cribriform to papillary) pattern of invasive prostate cancer is associated with adverse pathologic features and leads to uniquely adverse outcomes. Sixteen papers and numerous abstracts have reached these conclusions concordantly. Not only does this justify removal of all cribriform cancer from Gleason grade 3, it shows that cribriform cancer has pathologic, outcome, and molecular features distinct from noncribriform Gleason grade 4...
August 17, 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28820624/retinopathy-and-optic-atrophy-expanding-the-phenotypic-spectrum-of-pathogenic-variants-in-the-aars2-gene
#20
Jason H Peragallo, Stephanie Keller, Marjo S van der Knaap, Bruno P Soares, Suma P Shankar
BACKGROUND: Optic atrophy may be the sequela of optic nerve injury due to any insult, including isolated and syndromic genetic diseases. Alanyl-tRNA synthetase 2 (AARS2) pathogenic variants have been reported to cause leukodystrophy with ovarian failure, and cardiomyopathy (#615889) as well as combined oxidative phosphorylation deficiency-8 (#614096). We report a young child who presented with decreased vision due to optic atrophy and was found to harbor missense variants in the AARS2 gene expanding the phenotypic expression of the AARS2 gene...
August 18, 2017: Ophthalmic Genetics
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