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Rukma Parthvi, Rutuja R Sikachi, Abhinav Agrawal, Ajay Adial, Abhinav Vulisha, Sameer Khanijo, Arunabh Talwar
Antiphospholipid (aPL) antibodies are antibodies specific for anionic phospholipids. They are immunoglobulins that attack phospholipids, phospholipid-binding proteins, or phospholipid-protein complexes and are detected in anticardiolipin and lupus anticoagulant assays. aPL antibodies are often associated with antiphospholipid syndrome (APS) which can be idiopathic or from secondary causes such as systemic lupus erythematosus (SLE), infection or drugs. They have also been shown to be associated with Pulmonary Hypertension...
August 2017: Intractable & Rare Diseases Research
Pablo Guisado Vasco, Gonzalo de Luna Cardenal, Isabel Martín Garrido, José Manuel Luque Pinilla, Guadalupe Fraile Rodríguez, Juan José Nava Mateo, Daniel Carnevalli Ruiz
The background of this study is to assess the accuracy of lung ultrasound (LUS) to diagnose interstitial lung disease (ILD) in Sjögren's syndrome (Sjs), in patients who have any alterations in pulmonary function tests (PFT) or respiratory symptoms. LUS was correlated with chest tomography (hrCT), considering it as the imaging gold standard technique to diagnose ILD. This is a pilot, multicenter, cross-sectional, and consecutive-case study. The inclusion criteria are ≥18 years old, Signs and symptoms: according to ACEG 2002 criteria, respiratory symptoms (dyspnea, cough), or any alterations in PFR...
April 2017: Internal and Emergency Medicine
L Fidler, K J Keen, Z Touma, S Mittoo
OBJECTIVES: This study examines the effect of pulmonary disease on patient-reported outcomes (PROs) and patient-performed outcome (PPO) in systemic lupus erythematosus (SLE) patients at a single tertiary referral center. METHODS: Pulmonary function tests (PFTs), chest imaging, SLE-related damage, and disease activity were examined in 110 SLE patients. Presence was noted of abnormal PFTs, pleural disease, pulmonary hypertension (PH), pulmonary infarction, interstitial lung disease (ILD), and shrinking lung syndrome (SLS)...
August 2016: Lupus
Florentine C Moazedi-Fuerst, Sonja Kielhauser, Kerstin Brickmann, Norbert Tripolt, Michael Meilinger, Andre Lufti, Winfried Graninger
OBJECTIVES: The usefulness of transthoracic ultrasound in the evaluation of lung diseases has been highlighted in the past decades. The aim of our study is to determine the diagnostic value of lung ultrasound in the detection of interstitial pulmonary fibrosis in patients with a rheumatic disease. Furthermore, we studied the possible correlation between the underlying disease and the frequency of pathological ultrasound findings. METHODS: A sample of 45 consecutive patients with RA (n=25), SSc (n=14) and SLE (n=6) and 40 healthy volunteers were enrolled into the study...
July 2015: Clinical and Experimental Rheumatology
Mohammed Moizuddin, Muhammed Imtiaz, Mohammed Nayeem, Ria Gripaldo
Interstitial Lung Disease Case Report PostersSESSION TYPE: Affiliate Case Report PosterPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Interstitial Lung disease (ILD) is generally a late feature in patients with progressive systemic sclerosis (PSS). We report a rare case of 30 year old female patient who presented with acute respiratory distress syndrome, noted to have diffuse alveolar damage (DAD) on tranbronchial lung biopsy and elevated serum Scl-70 antibodies with no clinical evidence of SclerodermaCASE PRESENTATION: 30 year old non-smoker female patient with presented with progressively worsening shortness of breath, productive cough, and fever of three weeks duration...
October 1, 2014: Chest
Li Wang, Feng-Chun Zhang, Hua Chen, Xuan Zhang, Dong Xu, Yong-Zhe Li, Qian Wang, Li-Xia Gao, Yun-Jiao Yang, Fang Kong, Ke Wang
AIM: To establish the frequency and clinical features of connective tissue diseases (CTDs) in a cohort of Chinese patients with primary biliary cirrhosis (PBC). METHODS: Three-hundred and twenty-two Chinese PBC patients were screened for the presence of CTD, and the systemic involvement was assessed. The differences in clinical features and laboratory findings between PBC patients with and without CTD were documented. The diversity of incidence of CTDs in PBC of different countries and areas was discussed...
August 21, 2013: World Journal of Gastroenterology: WJG
Charo Francisco
SESSION TYPE: ILD Global Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Interstitial lung disease (ILD) includes a large, heterogeneous group of mostly rare pulmonary conditions that cause derangements of the alveolar walls and loss of functional alveolar capillary units, consisting of both known and unknown causes that share common histological features. It is influenced by several factors such as host susceptibility, genetics and environmental aspects. Familial ILD is identified by verifying in two or more members of the same family...
October 1, 2012: Chest
Markus Gutsche, Glenn D Rosen, Jeffrey J Swigris
Interstitial lung disease (ILD) is commonly encountered in patients with connective tissue diseases (CTD). Besides the lung parenchyma, the airways, pulmonary vasculature and structures of the chest wall may all be involved, depending on the type of CTD. As a result of this so-called multi-compartment involvement, airflow limitation, pulmonary hypertension, vasculitis and extrapulmonary restriction can occur alongside fibro-inflammatory parenchymal abnormalities in CTD. Rheumatoid arthritis (RA), systemic sclerosis (SSc), poly-/dermatomyositis (PM/DM), Sjögren's syndrome (SjS), systemic lupus erythematosus (SLE), and undifferentiated (UCTD) as well as mixed connective tissue disease (MCTD) can all be associated with the development of ILD...
September 21, 2012: Current Respiratory Care Reports
I Puxeddu, F Bongiorni, D Chimenti, S Bombardieri, A Moretta, C Bottino, P Migliorini
OBJECTIVES: A defined role for natural killer (NK) cells and their activating receptors in autoimmunity has not been clearly established. The aim of this study was to evaluate the levels of the CD3-CD56+ NK cells and their expression of receptors and co-receptors in the peripheral blood of patients with systemic autoimmune disorders. METHODS: Thirty-four subjects with systemic sclerosis (SSc), 14 with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), 14 with systemic lupus erythematosus (SLE), and 14 healthy donors were studied...
August 2012: Scandinavian Journal of Rheumatology
Aude Rigolet, Lucile Musset, Odile Dubourg, Thierry Maisonobe, Philippe Grenier, Jean-Luc Charuel, Anthony Behin, Serge Herson, Zahir Amoura, Olivier Benveniste
Anti-Ku antibodies have been reported in a wide spectrum of autoimmune diseases, sometimes in association with inflammatory myopathies (IM). We studied the clinical, laboratory, and muscle histologic features of all anti-Ku-positive patients detected in our hospital during the last 10 years, as well as their treatment and outcomes. Anti-Ku antibodies were found in 34 patients (0.46% of 20,600 sera positive for antinuclear antibodies), and complete data were available for 30 patients; 86.7% were female, mean age was 49 years (range, 20-73 yr)...
March 2012: Medicine (Baltimore)
Faranak Esmaeilbeigi, Stephen Juvet, David Hwang, Shikha Mittoo
Desquamative interstitial pneumonia (DIP) is a rare form of interstitial lung disease (ILD) commonly found among healthy smokers. ILD is a rare manifestation of systemic lupus erythematosus (SLE), and typically associated with a histopathological pattern of nonspecific interstitial pneumonia (NSIP). The present article describes an unusual case of DIP in a nonsmoking patient with SLE presenting as NSIP. DIP can occur in the context of SLE in patients with a negative smoking history, and clinicians should consider lung biopsy to correctly classify ILD with unusual presentation on computed tomography scan...
January 2012: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Stylianos T Panopoulos, Petros P Sfikakis
PURPOSE OF REVIEW: There is no specific therapy for interstitial lung disease associated with connective tissue diseases (CTDs-ILD), a potentially fatal condition for some of these patients. This article reviews currently available information on the effects on CTDs-ILD of biological treatments that are increasingly used with considerable success in various systemic diseases. RECENT FINDINGS: A beneficial effect of antitumor necrosis factor (TNF) agents on CTDs-ILD has been described in sporadic patients with rheumatoid arthritis (RA), systemic sclerosis (SSc) and systemic lupus erythematosus (SLE)...
September 2011: Current Opinion in Pulmonary Medicine
Anna Polgár, Csilla Rózsa, Veronika Müller, Judit Matolcsi, Gyula Poór, Emese Virág Kiss
Neuromyelitis optica (NMO, Devic's disease), an uncommon demyelinating neuro-immunological disease, can be associated with autoimmune diseases. In SLE associated forms anti-aquaporin-4 antibody positivity can help differentiating between SLE nerve system manifestation and NMO. In the literature rituximab, or immunoablative dose cyclophosphamide (CYC) was effective for the therapy resistant forms. Authors present 2 SLE overlapping NMO cases, one of them with SLE associated interstitial lung disease (ILD). In both cases neurological manifestations anticipated other SLE symptoms...
January 2011: Autoimmunity Reviews
S M Sant, M Doran, H M Fenelon, E S Breatnach
OBJECTIVE: To assess the nature of pleuropulmonary abnormalities, with particular reference to interstitial lung disease (ILD), in patients with systemic lupus erythematosus (SLE). METHODS: 29 patients were prospectively evaluated using high resolution computed tomography (HRCT), plain chest radiography (CXR) and pulmonary function tests (PFTs). Clinical assessments, drug therapy, disease activity, smoking status and serologic markers were also noted. RESULTS: The HRCT was abnormal in 72% (20/29) of patients, while 34% (10/29) had an abnormal CXR...
September 1997: Clinical and Experimental Rheumatology
L Weinrib, O P Sharma, F P Quismorio
The clinical course of chronic diffuse interstitial lung disease (ILD) was studied in 14 patients with SLE. The mean duration of follow-up was 7.3 years. All patients had dyspnea on exertion, pleuritic chest pain, chronic cough, and basilar rales. Chest roentgenogram showed diffuse or basilar infiltrates, pleural disease, and elevation of both diaphragms. Systemic corticosteroids were given early in the course of the illness for lung involvement and multisystem disease. Diffusing capacity for carbon monoxide (DLCO) and inspiratory vital capacity (IVC) improved or remained unchanged in the majority of patients...
August 1990: Seminars in Arthritis and Rheumatism
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