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JOURNAL ARTICLE
Menno T Maris, Ayca Koçar, Dick L Willems, Jeannette Pols, Hanno L Tan, Georg L Lindinger, Marieke A R Bak
BACKGROUND: The emergence of artificial intelligence (AI) in medicine has prompted the development of numerous ethical guidelines, while the involvement of patients in the creation of these documents lags behind. As part of the European PROFID project we explore patient perspectives on the ethical implications of AI in care for patients at increased risk of sudden cardiac death (SCD). AIM: Explore perspectives of patients on the ethical use of AI, particularly in clinical decision-making regarding the implantation of an implantable cardioverter-defibrillator (ICD)...
April 4, 2024: BMC Medical Ethics
#22
JOURNAL ARTICLE
Joud El Dick, Palak Shah, Asit Kr Paul
INTRODUCTION: Anticoagulation is the mainstay of management for patients with venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE). Inferior vena cava (IVC) filters are indicated in select patients who are not candidates for anticoagulation. There is a lack of quality evidence supporting other indications. In addition, long-term benefits and safety profiles of IVC filters have not been established. We investigated the utilization practice of IVC filters in a contemporary series of patients in a tertiary academic medical center...
March 2024: Curēus
#23
JOURNAL ARTICLE
Dick Schijven, Sourena Soheili-Nezhad, Simon E Fisher, Clyde Francks
Handedness is a manifestation of brain hemispheric specialization. Left-handedness occurs at increased rates in neurodevelopmental disorders. Genome-wide association studies have identified common genetic effects on handedness or brain asymmetry, which mostly involve variants outside protein-coding regions and may affect gene expression. Implicated genes include several that encode tubulins (microtubule components) or microtubule-associated proteins. Here we examine whether left-handedness is also influenced by rare coding variants (frequencies ≤ 1%), using exome data from 38,043 left-handed and 313,271 right-handed individuals from the UK Biobank...
April 2, 2024: Nature Communications
#24
JOURNAL ARTICLE
Cari Malcolm, Pat Hoddinott, Emma King, Smita Dick, Richard Kyle, Philip Wilson, Emma France, Lorna Aucott, Stephen W Turner
OBJECTIVE: To inform interventions focused on safely reducing urgent paediatric short stay admissions (SSAs) for convulsions. METHODS: Routinely acquired administrative data from hospital admissions in Scotland between 2015-2017 investigated characteristics of unscheduled SSAs (an urgent admission where admission and discharge occur on the same day) for a diagnosis of febrile and/or afebrile convulsions. Semi-structured interviews to explore perspectives of health professionals (n = 19) making referral or admission decisions about convulsions were undertaken...
2024: PloS One
#25
JOURNAL ARTICLE
Alex Yao Sokemawu Freeman, Aaron Ganizani, Annie Chauma Mwale, Innocent Kauta Manda, James Chitete, Gift Phiri, Bashil Stambuli, Elias Chimulambe, Mougabe Koslengar, Neema Rusibamayila Kimambo, Alisa Bita, Rebecca Racheal Apolot, Hamid Mponda, Randy George Mungwira, Gertrude Chapotera, Chol Thabo Yur, Nelly Jepkonga Yatich, Terence Totah, Freddie Mantchombe, Dick Damas Chamla, Olushayo Oluseun Olu
Anecdotal evidence and available literature indicated that contaminated water played a major role in spreading the prolonged cholera epidemic in Malawi from 2022 to 2023. This study assessed drinking water quality in 17 cholera-affected Malawi districts from February to April 2023. Six hundred and thirty-three records were analysed. The median counts/100 ml for thermotolerant coliform was 98 (interquartile range (IQR): 4-100) and that for Escherichia coli was 0 (IQR: 0-9). The drinking water in all (except one) districts was contaminated by thermotolerant coliform, while six districts had their drinking water sources contaminated by E...
March 2024: Journal of Water and Health
#26
REVIEW
Jasmine Brown, Lachlan Dick, Angus Watson
Volvulus describes the twisting of the intestine or colon around its mesentery. Intestinal obstruction and/or ischaemia are the most common complications of volvulus. Within the gastrointestinal tract, there is a preponderance towards colonic volvulus. The sigmoid is the most commonly affected segment, followed by the caecum, small intestine and stomach. Distinguishing between the differing anatomical locations of gastrointestinal volvulus can be challenging, but is important for the management and prognosis...
March 2, 2024: British Journal of Hospital Medicine
#27
JOURNAL ARTICLE
Felipe Correa-da-Silva, Jenny Carter, Xin-Yuan Wang, Rui Sun, Ekta Pathak, José Manuel Monroy Kuhn, Sonja C Schriever, Clarissa M Maya-Monteiro, Han Jiao, Martin J Kalsbeek, Pedro M M Moraes-Vieira, Johan J P Gille, Margje Sinnema, Constance T R M Stumpel, Leopold M G Curfs, Dirk Jan Stenvers, Paul T Pfluger, Dominik Lutter, Alberto M Pereira, Andries Kalsbeek, Eric Fliers, Dick F Swaab, Lawrence Wilkinson, Yuanqing Gao, Chun-Xia Yi
Prader-Willi Syndrome (PWS) is a rare neurodevelopmental disorder of genetic etiology, characterized by paternal deletion of genes located at chromosome 15 in 70% of cases. Two distinct genetic subtypes of PWS deletions are characterized, where type I (PWS T1) carries four extra haploinsufficient genes compared to type II (PWS T2). PWS T1 individuals display more pronounced physiological and cognitive abnormalities than PWS T2, yet the exact neuropathological mechanisms behind these differences remain unclear...
March 31, 2024: Acta Neuropathologica
#28
JOURNAL ARTICLE
Rovina Ruslami, Federica Fregonese, Lika Apriani, Leila Barss, Nancy Bedingfield, Victor Chiang, Victoria J Cook, Dina Fisher, Eri Flores, Greg J Fox, James Johnston, Rachel K Lim, Richard Long, Catherine Paulsen, Thu Anh Nguyen, Nguyen Viet Nhung, Diana Gibson, Chantal Valiquette, Andrea Benedetti, Dick Menzies
BACKGROUND: Tuberculosis preventive treatment (TPT) is a key component of tuberculosis elimination. To improve completion and reduce the burden for people and health systems, short, safe, and effective TPT regimens are needed. We aimed to compare safety and treatment completion of various doses and durations of rifampicin in people who were recommended to receive TPT. METHODS: This partially blinded, parallel-arm, non-inferiority, randomised, controlled, phase 2b trial was done at seven university-affiliated clinics in Canada, Indonesia, and Viet Nam...
March 26, 2024: Lancet Respiratory Medicine
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JOURNAL ARTICLE
Gertie H P Arts, Jasper van Smeden, Marieke F Wolters, J Dick M Belgers, Arrienne M Matser, Udo Hommen, Eric Bruns, Simon Heine, Andreas Solga, Seamus Taylor
Lemna L. sp. is a free-floating aquatic macrophyte that plays a key role as a standard test species in aquatic risk assessment for herbicides and other contaminants. Population modeling can be used to extrapolate from laboratory to field conditions. However, there are insufficient data on longer-term seasonal dynamics of this species to evaluate such models. Therefore, several long-term growth experiments were conducted in outdoor microcosms (surface area 0.174 m2 ). Monitoring parameters included biomass, frond numbers, water parameters, and weather data...
March 28, 2024: Integrated Environmental Assessment and Management
#30
REVIEW
Leon M T Dicks, Wian Vermeulen
Healthcare faces a major problem with the increased emergence of antimicrobial resistance due to over-prescribing antibiotics. Bacteriophages may provide a solution to the treatment of bacterial infections given their specificity. Enzymes such as endolysins, exolysins, endopeptidases, endosialidases, and depolymerases produced by phages interact with bacterial surfaces, cell wall components, and exopolysaccharides, and may even destroy biofilms. Enzymatic cleavage of the host cell envelope components exposes specific receptors required for phage adhesion...
March 20, 2024: Viruses
#31
JOURNAL ARTICLE
Ashutosh Rana, James H Nguyen, Christophe Renault, Jeffrey E Dick
Droplet evaporation has previously been used as a concentration enrichment strategy; however, the measurement technique of choice requires quantification in rather large volumes. Electrochemistry has recently emerged as a method to robustly probe volumes even down to the attoliter (10-18 L) level. We present a concentration enrichment strategy based on the dissolution of a microdroplet placed on the surface of a Au ultramicroelectrode (radius ∼ 6.25 μm). By precisely positioning a 1,2-dichloroethane microdroplet onto the ultramicroelectrode with a microinjector, we are able to track the droplet's behavior optically and electrochemically...
March 27, 2024: Analytical Chemistry
#32
JOURNAL ARTICLE
Nefyn H Williams, Brendan Collins, Terence J Comerford, Susanna Dodd, Michael Fisher, Ben Hardwick, Sophie Hennessy, Kate Jolly, Ian Jones, Deirdre Lane, Gregory Y H Lip, Erica Morgan, Penelope Ralph, Dick Thijssen, Sally J Singh
INTRODUCTION: Chronic stable angina is common and disabling. Cardiac rehabilitation is routinely offered to people following myocardial infarction or revascularisation procedures and has the potential to help people with chronic stable angina. However, there is insufficient evidence of effectiveness and cost-effectiveness for its routine use in this patient group. The objectives of this study are to compare the effectiveness and cost-effectiveness of the 'Activate Your Heart' cardiac rehabilitation programme for people with chronic stable angina compared with usual care...
March 25, 2024: BMJ Open
#33
Sergey Koren, Zhigui Bao, Andrea Guarracino, Shujun Ou, Sara Goodwin, Katharine M Jenike, Julian Lucas, Brandy McNulty, Jimin Park, Mikko Rautianinen, Arang Rhie, Dick Roelofs, Harrie Schneiders, Ilse Vrijenhoek, Koen Nijbroek, Doreen Ware, Michael C Schatz, Erik Garrison, Sanwen Huang, William Richard McCombie, Karen H Miga, Alexander H J Wittenberg, Adam M Phillippy
The combination of ultra-long Oxford Nanopore (ONT) sequencing reads with long, accurate PacBio HiFi reads has enabled the completion of a human genome and spurred similar efforts to complete the genomes of many other species. However, this approach for complete, "telomere-to-telomere" genome assembly relies on multiple sequencing platforms, limiting its accessibility. ONT "Duplex" sequencing reads, where both strands of the DNA are read to improve quality, promise high per-base accuracy. To evaluate this new data type, we generated ONT Duplex data for three widely-studied genomes: human HG002, Solanum lycopersicum Heinz 1706 (tomato), and Zea mays B73 (maize)...
March 19, 2024: bioRxiv
#34
JOURNAL ARTICLE
Mory Keita, Samuel T Boland, Joseph Okeibunor, Dick Chamla, Abdou Salam Gueye, Matshidiso Moeti
No abstract text is available yet for this article.
March 22, 2024: Lancet
#35
JOURNAL ARTICLE
Laurent G Glance, Karen E Joynt Maddox, Michael Mazzeffi, Ernie Shippey, Katherine L Wood, E Yoko Furuya, Patricia W Stone, Jingjing Shang, Isaac Y Wu, Igor Gosev, Stewart J Lustik, Heather L Lander, Julie A Wyrobek, Andres Laserna, Andrew W Dick
BACKGROUND: The objective of this study was to examine insurance-based disparities in mortality, non-home discharges, and ECMO utilization in patients hospitalized with COVID-19. METHODS: Using a national database of U.S. academic medical centers and their affiliated hospitals, the risk-adjusted association between mortality, non-home discharge, and ECMO utilization and (1) the type of insurance coverage (private insurance, Medicare, dual enrollment in Medicare and Medicaid, and no insurance) and (2) the weekly hospital COVID-19 burden (0-5...
March 25, 2024: Anesthesiology
#36
JOURNAL ARTICLE
Rebecca L Smith, Thomas Bannard, Jessica McDaniel, Fazil Aliev, Austin Brown, Erica Holliday, Noel Vest, Waltrina DeFrantz-Dufor, Danielle M Dick
The goals of the present study were to describe the development of the first national longitudinal study of collegiate recovery programs (CRP) students; provide an updated characterization of CRP students' demographics, past problem severity, and current recovery-related functioning; and examine the perceived impact of COVID-19 on CRP students' recovery. Universities and community colleges with CRPs across the United States and Ontario, Canada, were invited to partner on this project. Launched in fall 2020, three cohorts of participants were recruited...
2024: Addiction Research & Theory
#37
EDITORIAL
Lorenzo Patrone, Edoardo Pasqui, Michael S Conte, Alik Farber, Roberto Ferraresi, Matthew Menard, Joseph L Mills, John Rundback, Peter Schneider, August Ysa, Kumar Abhishek, George L Adams, Naseer Ahmad, Irfan Ahmed, Vlad A Alexandrescu, Max Amor, David Alper, Martin Andrassy, Christopher Attinger, Andy Baadh, Hashem Barakat, Lukla Biasi, Theodosios Bisdas, Zagum Bhatti, Erwin Blessing, Marc P Bonaca, Stefano Bonvini, Michel Bosiers, Andrew W Bradbury, Robert Beasley, Christian-Alexander Behrendt, Marianne Brodmann, Gonzalo Cabral, Roberto Cancellieri, Andrea Casini, Venita Chandra, Emiliano Chisci, Omar Chohan, Edward T C Choke, Patrick F S Chong, Giacomo Clerici, Raphael Coscas, Mary Costantino, Luca Dalla Paola, Sabeen Dand, Robert S M Davies, Mario D'Oria, Athanasios Diamantopoulos, Sebastian Debus, Koen Deloose, Costantino Del Giudice, Gianmarco de Donato, Brian De Rubertis, Jean Paul De Vries, Nuno V Dias, Larry Diaz-Sandoval, Florian Dick, Konstantinos Donas, Anahita Dua, Fabrizio Fanelli, Stefano Fazzini, Mazin Foteh, Roberto Gandini, Mauro Gargiulo, Luca Garriboli, Elizabeth A Genovese, Edward Gifford, Yann Goueffic, Peter Goverde, Prem Chand Gupta, Robert Hinchliffe, Andrew Holden, Kim C Houlind, Dominic Pj Howard, Bella Huasen, Giacomo Isernia, Konstantinos Katsanos, Barry Katzen, Philippe Kolh, Igor Koncar, Grigorios Korosoglou, Prakash Krishnan, Thomas Kroencke, Miltiadis Krokidis, Arun Kumarasamy, Paul Hayes, Osamu Iida, Enrique Alejandre Lafont, Ralf Langhoff, Alexandre Lecis, Mark Lessne, Hady Lichaa, Michael Lichtenberg, Marta Lobato, Alice Lopes, Giorgio Loreni, Pierleone Lucatelli, Sreekumar Madassery, Lieven Maene, Marco Manzi, Martin Maresch, Jay Santhosh Mathews, James McCaslin, Antonio Micari, Stefano Michelagnoli, Bruno Migliara, Robert Morgan, Luis Morelli, Daniele Morosetti, Nicolas Mouawad, Paul Moxey, Stefan Müller-Hülsbeck, Jihad Mustapha, Tatsuya Nakama, Bahaa Nasr, Zola N'dandu, Richard Neville, Elias Noory, Joakim Nordanstig, Katariina Noronen, Luis Mariano Palena, Gianbattista Parlani, Ashish S Patel, Parag Patel, Rafiuddin Patel, Sanjay Patel, Costantino Pena, Drazen Perkov, Mark Portou, Giovanni Pratesi, Christos Rammos, Jim Reekers, Vicente Riambau, Trisha Roy, Kenneth Rosenfield, Maria Antonella Ruffino, Fadi Saab, Athanasios Saratzis, Paolo Sbarzaglia, Andrej Schmidt, Eric Secemsky, Michael Siah, Henrik Sillesen, Gioele Simonte, Marc Sirvent, Jill Sommerset, Sabine Steiner, Ahmed Sakr, Dierk Scheinert, Mehdi Shishebor, Stavros Spiliopoulos, Alessio Spinelli, Konstantinos Stravoulakis, Gergana Taneva, Desarom Teso, Joerg Tessarek, Selva Theivacumar, Anish Thomas, Shannon Thomas, Narayan Thulasidasan, Giovanni Torsello, Ramesh Tripathi, Nicola Troisi, Srini Tummala, Venkat Tummala, Christopher Twine, Raman Uberoi, Alessandro Ucci, Domenico Valenti, Jos van den Berg, Daniel van den Heuvel, Isabelle Van Herzeele, Ramon Varcoe, Melina Vega de Ceniga, Frank J Veith, Maarit Venermo, Badri Vijaynagar, Sanjiv Virdee, Conrad Von Stempel, Michiel T Voûte, Kak Khee Yeung, Thomas Zeller, Hany Zayed, Miguel Montero Baker
No abstract text is available yet for this article.
March 25, 2024: Journal of Endovascular Therapy
#38
JOURNAL ARTICLE
Albert J de Neeling, Elisa Tagliani, Csaba Ködmön, Marieke J van der Werf, Dick van Soolingen, Daniela Maria Cirillo, Richard M Anthony
BackgroundThe EUSeqMyTB project, conducted in 2020, used whole genome sequencing (WGS) for surveillance of drug-resistant Mycobacterium tuberculosis in the European Union/European Economic Area (EU/EEA) and identified 56 internationally clustered multidrug-resistant (MDR) tuberculosis (TB) clones.AimWe aimed to define and establish a rapid and computationally simple screening method to identify probable members of the main cross-border MDR-TB clusters in WGS data to facilitate their identification and track their future spread...
March 2024: Euro Surveillance
#39
JOURNAL ARTICLE
Sabrina Reinehr, Julien Wulf, Janine Theile, Kim K Schulte, Marcus Peters, Rudolf Fuchshofer, H Burkhard Dick, Stephanie C Joachim
BACKGROUND: The neurodegenerative processes leading to glaucoma are complex. In addition to elevated intraocular pressure (IOP), an involvement of immunological mechanisms is most likely. In the new multifactorial glaucoma model, a combination of high IOP and optic nerve antigen (ONA) immunization leads to an enhanced loss of retinal ganglion cells accompanied by a higher number of microglia/macrophages in the inner retina. Here, we aimed to evaluate the immune response in this new model, especially the complement activation and the number of T-cells, for the first time...
2024: Frontiers in Immunology
#40
JOURNAL ARTICLE
Xu Li, Tongzhou Liang, Bingyang Dai, Liang Chang, Yuan Zhang, Shiwen Hu, Jiaxin Guo, Shunxiang Xu, Lizhen Zheng, Hao Yao, Hong Lian, Yu Nie, Ye Li, Xuan He, Zhi Yao, Wenxue Tong, Xinluan Wang, Dick Ho Kiu Chow, Jiankun Xu, Ling Qin
Elevated bone resorption and diminished bone formation have been recognized as the primary features of glucocorticoid-associated skeletal disorders. However, the direct effects of excess glucocorticoids on bone turnover remains unclear. Here, we explored the outcomes of exogenous glucocorticoid treatment on bone loss and delayed fracture healing in mice and found that reduced bone turnover was a dominant feature, resulting in a net loss of bone mass. The primary effect of glucocorticoids on osteogenic differentiation was not inhibitory; instead, they cooperated with macrophages to facilitate osteogenesis...
March 21, 2024: Journal of Clinical Investigation
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