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https://www.readbyqxmd.com/read/27920338/the-plethora-gene-regulatory-network-guides-growth-and-cell-differentiation-in-arabidopsis-roots
#1
Luca Santuari, Gabino Sanchez-Perez, Marijn Luijten, Bas Rutjens, Inez Terpstra, Lidija Berke, Maartje Gorte, Kalika Prasad, Dongping Bao, Johanna L P M Timmermans-Hereijgers, Kenichiro Maeo, Kenzo Nakamura, Akie Shimotohno, Ales Pencik, Ondřej Novák, Karin Ljung, Sebastiaan van Heesch, Ewart de Bruijn, Edwin Cuppen, Viola Willemsen, Ari Pekka Mähönen, Wolfgang Lukowitz, Berend Snel, Dick de Ridder, Ben Scheres, Renze Heidstra
Organ formation in animals and plants relies on precise control of cell state transitions to turn stem cell daughters into fully differentiated cells. In plants, cells cannot rearrange due to shared cell walls. Thus, differentiation progression and the accompanying cell expansion must be tightly coordinated across tissues. PLETHORA (PLT) transcription factor gradients are unique in their ability to guide the progression of cell differentiation at different positions in the growing Arabidopsis root, which contrasts with well-described transcription factor gradients in animals specifying distinct cell fates within an essentially static context...
December 5, 2016: Plant Cell
https://www.readbyqxmd.com/read/27919541/pesticides-drive-risk-of-micropollutants-in-wastewater-impacted-streams-during-low-flow-conditions
#2
Nicole A Munz, Francis J Burdon, Dick de Zwart, Marion Junghans, Laura Melo, Marta Reyes, Urs Schönenberger, Heinz P Singer, Barbara Spycher, Juliane Hollender, Christian Stamm
Micropollutants enter surface waters through various pathways, of which wastewater treatment plants (WWTPs) are a major source. The large diversity of micropollutants and their many modes of toxic action pose a challenge for assessing environmental risks. In this study, we investigated the potential impact of WWTPs on receiving ecosystems by describing concentration patterns of micropollutants, predicting acute risks for aquatic organisms and validating these results with macroinvertebrate biomonitoring data...
November 3, 2016: Water Research
https://www.readbyqxmd.com/read/27919392/knowledge-management-systems-success-in-healthcare-leadership-matters
#3
Nor'ashikin Ali, Alexei Tretiakov, Dick Whiddett, Inga Hunter
PURPOSE: To deliver high-quality healthcare doctors need to access, interpret, and share appropriate and localised medical knowledge. Information technology is widely used to facilitate the management of this knowledge in healthcare organisations. The purpose of this study is to develop a knowledge management systems success model for healthcare organisations. METHOD: A model was formulated by extending an existing generic knowledge management systems success model by including organisational and system factors relevant to healthcare...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27919349/familial-combined-hyperlipidemia-and-hyperlipoprotein-a-as-phenotypic-mimics-of-familial-hypercholesterolemia-frequencies-associations-and-predictions
#4
Katrina L Ellis, Jing Pang, Dick C Chan, Amanda J Hooper, Damon A Bell, John R Burnett, Gerald F Watts
BACKGROUND: A significant proportion of index cases presenting with phenotypic familial hypercholesterolemia (FH) are not found to have a pathogenic mutation and may have other inherited conditions. OBJECTIVES: Familial combined hyperlipidemia (FCHL) and elevated lipoprotein(a) [Lp(a)] may mimic FH, but the frequency and correlates of these disorders among mutation-negative FH patients have yet to be established. METHODS: The frequency of FCHL and elevated Lp(a) was investigated in 206 FH mutation-negative index cases attending a specialist lipid clinic...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27918926/childhood-adversity-impacts-on-brain-subcortical-structures-relevant-to-depression
#5
Thomas Frodl, Deborah Janowitz, Lianne Schmaal, Leonardo Tozzi, Henrik Dobrowolny, Dan J Stein, Dick J Veltman, Katharina Wittfeld, Theo G M van Erp, Neda Jahanshad, Andrea Block, Katrin Hegenscheid, Henry Völzke, Jim Lagopoulos, Sean N Hatton, Ian B Hickie, Eva Maria Frey, Angela Carballedo, Samantha J Brooks, Daniella Vuletic, Anne Uhlmann, Ilya M Veer, Henrik Walter, Knut Schnell, Dominik Grotegerd, Volker Arolt, Harald Kugel, Elisabeth Schramm, Carsten Konrad, Bartosz Zurowski, Bernhard T Baune, Nic J A van der Wee, Marie-Jose van Tol, Brenda W J H Penninx, Paul M Thompson, Derrek P Hibar, Udo Dannlowski, Hans J Grabe
Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis...
November 19, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27916863/lipid-composition-of-oil-extracted-from-wasted-norway-lobster-nephrops-norvegicus-heads-and-comparison-with-oil-extracted-from-antarctic-krill-euphasia-superba
#6
Amaya Albalat, Lauren E Nadler, Nicholas Foo, James R Dick, Andrew J R Watts, Heather Philp, Douglas M Neil, Oscar Monroig
In the UK, the Norway lobster (Nephrops norvegicus) supports its most important shellfish fishery. Nephrops are sold either whole, or as "tails-only" for the scampi trade. In the "tailing" process, the "head" (cephalothorax) is discarded as waste. A smaller crustacean species, the Antarctic krill Euphasia superba, represents an economically valuable industry, as its extractable oil is sold as a human dietary supplement. The aim of this study was to determine the amount and composition of the oil contained in discarded Nephrops heads and to compare its composition to the oil extracted from krill...
December 1, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27912012/coast-wide-recruitment-dynamics-of-olympia-oysters-reveal-limited-synchrony-and-multiple-predictors-of-failure
#7
Kerstin Wasson, Brent B Hughes, John S Berriman, Andrew L Chang, Anna K Deck, Paul A Dinnel, Charlie Endris, Michael Espinoza, Sarah Dudas, Matthew C Ferner, Edwin D Grosholz, David Kimbro, Jennifer L Ruesink, Alan C Trimble, Dick Vander Schaaf, Chela J Zabin, Danielle C Zacherl
Recruitment of new propagules into a population can be a critical determinant of adult density. We examined recruitment dynamics in the Olympia oyster (Ostrea lurida), a species occurring almost entirely in estuaries. We investigated spatial scales of interannual synchrony across 37 sites in eight estuaries along 2,500 km of Pacific North American coastline, predicting that high vs. low recruitment years would coincide among neighboring estuaries due to shared exposure to regional oceanographic factors. Such synchrony in recruitment has been found for many marine species and some migratory estuarine species, but has never been examined across estuaries in a species that can complete its entire life cycle within the same estuary...
December 2016: Ecology
https://www.readbyqxmd.com/read/27911553/arbitrary-dicke-state-control-of-symmetric-rydberg-ensembles
#8
Tyler Keating, Charles H Baldwin, Yuan-Yu Jau, Jongmin Lee, Grant W Biedermann, Ivan H Deutsch
We study the production of arbitrary superpositions of Dicke states via optimal control. We show that N atomic hyperfine qubits, interacting symmetrically via the Rydberg blockade, are well described by the Jaynes-Cummings Hamiltonian and fully controllable by phase-modulated microwaves driving Rydberg-dressed states. With currently feasible parameters, it is possible to generate states of ∼ten hyperfine qubits in ∼1  μs, assuming a fast microwave phase switching time. The same control can be achieved with a "dressed-ground control" scheme, which reduces the demands for fast phase switching at the expense of increased total control time...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27911541/multipartite-entanglement-detection-with-minimal-effort
#9
Lukas Knips, Christian Schwemmer, Nico Klein, Marcin Wieśniak, Harald Weinfurter
Certifying entanglement of a multipartite state is generally considered a demanding task. Since an N qubit state is parametrized by 4^{N}-1 real numbers, one might naively expect that the measurement effort of generic entanglement detection also scales exponentially with N. Here, we introduce a general scheme to construct efficient witnesses requiring a constant number of measurements independent of the number of qubits for states like, e.g., Greenberger-Horne-Zeilinger states, cluster states, and Dicke states...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27909889/long-term-results-of-a-modified-expansion-sphincter-pharyngoplasty-for-sleep-disordered-breathing
#10
Anne-Sophie Despeghel, Lisabeth Mus, Catherine Dick, Stephan Vlaminck, Rudolf Kuhweide, Bob Lerut, Kato Speleman, Anne-Sophie Vinck, Tom Vauterin
Our aim was to evaluate the long-term objective and subjective results of a modified expansion sphincter pharyngoplasty (ESP) technique in patients with sleep-disordered breathing. Single center prospective study of 35 patients underwent an ESP as a primary surgical treatment between June 2012 and September 2015 at the hospital AZ Sint-Jan Bruges-Ostend. Patients were divided into non-OSAS and OSAS (AHI >5). Primary outcome parameters were the Epworth Sleeping Scale (ESS, reduction and score less then 10) and the Visual Analogue Score of snoring (VAS, assessed by partner) evaluated at 3 months and 1 year...
December 1, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27907936/early-treatment-for-neonatal-abstinence-syndrome-a-palliative-approach
#11
Jennifer Hudson, Rachel Mayo, Lori Dickes, Liwei Chen, Windsor Westbrook Sherrill, Julie Summey, Bradley Dalton, Kindal Dankovich
Objective To describe medical, safety, and health care utilization outcomes associated with an early treatment model for neonatal opioid withdrawal. Study Design This is a retrospective review of 117 opioid-exposed infants born in a large regional hospital and treated in the level I nursery with methadone initiated within 48 hours of birth. Results For this cohort, mean length of stay was 8.3 days. Hospital safety events were infrequent; there were no medication errors or deaths. Within 30 days of discharge, 14% of infants visited the emergency department; 7% were readmitted...
December 1, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27900443/p450bm3-fused-to-phosphite-dehydrogenase-allows-phosphite-driven-selective-oxidations
#12
Nina Beyer, Justyna K Kulig, Anette Bartsch, Martin A Hayes, Dick B Janssen, Marco W Fraaije
To facilitate the wider application of the NADPH-dependent P450BM3, we fused the monooxygenase with a phosphite dehydrogenase (PTDH). The resulting monooxygenase-dehydrogenase fusion enzyme acts as a self-sufficient bifunctional catalyst, accepting phosphite as a cheap electron donor for the regeneration of NADPH.The well-expressed fusion enzyme was purified and analyzed in comparison to the parent enzymes. Using lauric acid as substrate for P450BM3, it was found that the fusion enzyme had similar substrate affinity and hydroxylation selectivity while it displayed a significantly higher activity than the non-fused monooxygenase...
November 29, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27897028/a-single-center-experience-with-isolated-limb-infusion-an-interventional-oncology-opportunity
#13
Adam DeFoe, Andrew Heckman, Dick Slater, Edibaldo Silva-Lopez, Jason Foster, Thom Bowden, Christopher Vargo
OBJECTIVE: This retrospective review details our experience with isolated limb infusion for the treatment of melanoma, squamous cell carcinoma, and sarcoma in-transit metastases performed entirely in the interventional radiology suite. Eleven patients were treated over a 3-year period. Treatment response was assessed clinically and with PET/CT. CONCLUSION: Eight patients had either complete or partial response, giving an overall response rate of 72%. Isolated limb infusion can efficiently be performed entirely in the interventional radiology suite...
November 29, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27894995/short-branches-lead-to-systematic-artifacts-when-blast-searches-are-used-as-surrogate-for-phylogenetic-reconstruction
#14
Amanda A Dick, Tim J Harlow, J Peter Gogarten
Long Branch Attraction (LBA) is a well-known artifact in phylogenetic reconstruction when dealing with branch length heterogeneity. Here we show another phenomenon, Short Branch Attraction (SBA), which occurs when BLAST searches, a phenetic analysis, are used as a surrogate method for phylogenetic analysis. This error also results from branch length heterogeneity, but this time it is the short branches that are attracting. The SBA artifact is reciprocal and can be returned 100% of the time when multiple branches differ in length by a factor of more than two...
November 25, 2016: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/27894766/risk-and-relevance-of-open-lung-biopsy-in-pediatric-ecmo-patients-the-dutch-experience
#15
Robert Jan Houmes, Chantal A Ten Kate, Enno D Wildschut, Rob M Verdijk, René M H Wijnen, Ivo de Blaauw, Dick Tibboel, Arno F van Heijst
BACKGROUND: Open lung biopsy can help differentiate between reversible and irreversible lung disease and may guide therapy. To assess the risk-benefit ratio of this procedure in pediatric extracorporeal membrane oxygenation (ECMO) patients, we reviewed data of all patients who underwent an open lung biopsy during ECMO in one of the two pediatric ECMO centers in a nationwide study in the Netherlands. RESULTS: In nineteen neonatal and six pediatric patients (0-15...
November 14, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27894704/antenatal-fetal-surveillance-in-multiple-pregnancies
#16
REVIEW
Dick Oepkes, Marieke Sueters
Multiple pregnancies occur either spontaneously or because of assisted reproduction techniques in 1-3% of pregnancies. The presence of more than one fetus in the womb is associated with a range of possible complications, both for the mother and fetuses. Early detection of these complications followed by timely and appropriate management will reduce the risk of adverse outcomes. The techniques, skills, and experience for timely detection of complications and managing them appropriately require sufficient training and exposure...
September 29, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27894123/safeguarding-pollinators-and-their-values-to-human-well-being
#17
Simon G Potts, Vera Imperatriz-Fonseca, Hien T Ngo, Marcelo A Aizen, Jacobus C Biesmeijer, Thomas D Breeze, Lynn V Dicks, Lucas A Garibaldi, Rosemary Hill, Josef Settele, Adam J Vanbergen
Wild and managed pollinators provide a wide range of benefits to society in terms of contributions to food security, farmer and beekeeper livelihoods, social and cultural values, as well as the maintenance of wider biodiversity and ecosystem stability. Pollinators face numerous threats, including changes in land-use and management intensity, climate change, pesticides and genetically modified crops, pollinator management and pathogens, and invasive alien species. There are well-documented declines in some wild and managed pollinators in several regions of the world...
November 28, 2016: Nature
https://www.readbyqxmd.com/read/27893244/temporal-ordering-effects-of-adolescent-depression-relational-aggression-and-victimization-over-six-waves-fully-latent-reciprocal-effects-models
#18
Herbert W Marsh, Rhonda G Craven, Philip D Parker, Roberto H Parada, Jiesi Guo, Theresa Dicke, Adel Salah Abduljabbar
The temporal ordering of depression, aggression, and victimization has important implications for theory, policy, and practice. For a representative sample of high school students (Grades 7-10; N = 3,793) who completed the same psychometrically strong, multiitem scales 6 times over a 2-year period, there were reciprocal effects between relational-aggression and relational-victimization factors: aggression led to subsequent victimization and victimization led to subsequent aggression. After controlling for prior depression, aggression, and victimization, depression had a positive effect on subsequent victimization, but victimization had no effect on subsequent depression...
December 2016: Developmental Psychology
https://www.readbyqxmd.com/read/27889452/an-rb-ezh2-complex-mediates-silencing-of-repetitive-dna-sequences
#19
Charles A Ishak, Aren E Marshall, Daniel T Passos, Carlee R White, Seung J Kim, Matthew J Cecchini, Sara Ferwati, William A MacDonald, Christopher J Howlett, Ian D Welch, Seth M Rubin, Mellissa R W Mann, Frederick A Dick
Repetitive genomic regions include tandem sequence repeats and interspersed repeats, such as endogenous retroviruses and LINE-1 elements. Repressive heterochromatin domains silence expression of these sequences through mechanisms that remain poorly understood. Here, we present evidence that the retinoblastoma protein (pRB) utilizes a cell-cycle-independent interaction with E2F1 to recruit enhancer of zeste homolog 2 (EZH2) to diverse repeat sequences. These include simple repeats, satellites, LINEs, and endogenous retroviruses as well as transposon fragments...
November 12, 2016: Molecular Cell
https://www.readbyqxmd.com/read/27888302/-macrophages-causing-ocular-metastasis-or-immune-reaction-on-tumor-cells-in-the-eye
#20
M I Wunderlich, E J Nissen, M Schargus, H B Dick, M Pohl, S E Coupland, V Kakkassery
No abstract text is available yet for this article.
November 25, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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