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https://www.readbyqxmd.com/read/28323856/risk-factors-for-esbl-producing-escherichia-coli-on-pig-farms-a-longitudinal-study-in-the-context-of-reduced-use-of-antimicrobials
#1
Wietske Dohmen, Alejandro Dorado-García, Marc J M Bonten, Jaap A Wagenaar, Dik Mevius, Dick J J Heederik
The presence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli) in food animals is a public health concern. This study aimed to determine prevalence of ESBL-E. coli on pig farms and to assess the effect of reducing veterinary antimicrobial use (AMU) and farm management practices on ESBL-E. coli occurrence on pig farms. During 2011-2013, 36 Dutch conventional pig farms participated in a longitudinal study (4 sampling times in 18 months). Rectal swabs were taken from 60 pigs per farm and pooled per 6 pigs within the same age category...
2017: PloS One
https://www.readbyqxmd.com/read/28318402/ipsilateral-scapular-cutaneous-anchor-system-an-alternative-for-the-harness-in-body-powered-upper-limb-prostheses
#2
Mona Hichert, Dick H Plettenburg
BACKGROUND: Body-powered prosthesis users frequently complain about the poor cosmesis and comfort of the traditional shoulder harness. The Ipsilateral Scapular Cutaneous Anchor System offers an alternative, but it remains unclear to what extent it affects the perception and control of cable operation forces compared to the traditional shoulder harness. OBJECTIVE: To compare cable force perception and control with the figure-of-nine harness versus the Ipsilateral Scapular Cutaneous Anchor System and to investigate force perception and control at different force levels...
March 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28317141/actor-and-partner-effects-of-attachment-on-relationship-satisfaction-and-sexual-satisfaction-across-the-genders-an-apim-approach
#3
Henk Jan Conradi, Arjen Noordhof, Pieter Dingemanse, Dick P H Barelds, Jan H Kamphuis
Previous studies found gender differences in relationship satisfaction and sexuality. We tested gender differences in associations between attachment, a lasting relationship determinant, and two outcomes, relationship and sexual satisfaction. This study improves on earlier research by examining these associations in one Actor-Partner-Interdependence-Model, making direct statistical testing between outcomes possible. Furthermore, a community and a distressed sample (N = 113 heterosexual couples each) were included to attempt replication across samples and to examine clinical implications...
March 20, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28317028/mycobacterial-caseinolytic-protease-gene-regulator-clgr-is-a-substrate-of-caseinolytic-protease
#4
Yoshiyuki Yamada, Thomas Dick
The mycobacterial caseinolytic protease ClpP1P2 is a degradative protease that recently gained interest as a genetically and pharmacologically validated drug target for tuberculosis. The first whole-cell active ClpP1P2 inhibitor, the human proteasome inhibitor bortezomib, is currently undergoing lead optimization to introduce selectivity for the bacterial target. How inhibition of ClpP1P2 translates into whole-cell antimicrobial activity is little understood. Previous work has shown that the caseinolytic protease gene regulator ClgR is an activator of the clpP1P2 genes and also suggested that this transcription factor may be a substrate of the protease...
March 2017: MSphere
https://www.readbyqxmd.com/read/28316912/intensity-of-commonly-reported-classroom-based-physical-activity-opportunities-in-public-schools
#5
Timothy K Behrens, Whitney M Holeva, Dick Carpenter, Elizabeth Tucker, Carmen Luna, John Donovan, Julaine Field, Cheryl Kelly
The purpose of this study was to examine the intensity levels of PA opportunities offered in public school classrooms. Schools (N = 101) in school districts (N = 25) reported PA opportunities offered in classrooms using an online data collection tool over a two-year period (2014-2016). Using a randomized sampling technique, 20-30% of teachers in each school were selected each week to report PA in their classroom. These responses resulted in N = 18,210 usable responses. A researcher determined the intensity of PA opportunities using the 2011 Compendium of Physical Activities as a guideline; two additional researchers confirmed the coded categories...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28316142/evolutionary-ecology-of-beta-lactam-gene-clusters-in-animals
#6
Wouter Suring, Karen Meusemann, Alexander Blanke, Janine Mariën, Tim Schol, Valeria Agamennone, Anna Faddeeva-Vakhrusheva, Matty P Berg, Bram Brouwer, Nico M van Straalen, Dick Roelofs
Beta-lactam biosynthesis was thought to occur only in fungi and bacteria, but we recently reported the presence of isopenicillin N synthase in a soil-dwelling animal, Folsomia candida. However, it has remained unclear whether this gene is part of a larger beta-lactam biosynthesis pathway and how widespread the occurrence of penicillin biosynthesis is among animals. Here, we analyzed the distribution of beta-lactam biosynthesis genes throughout the animal kingdom and identified a beta-lactam gene cluster in the genome of F...
March 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28314756/predicting-occupational-asthma-and-rhinitis-in-bakery-workers-referred-for-clinical-evaluation
#7
Badri Sadat Jonaid, Jos Rooyackers, Erik Stigter, Lützen Portengen, Esmeralda Krop, Dick Heederik
BACKGROUND: Occupational allergic diseases are a major problem in some workplaces like in the baking industry. Diagnostic rules have been used in surveillance but not yet in the occupational respiratory clinic. OBJECTIVE: To develop diagnostic models predicting baker's asthma and rhinitis among bakery workers at high risk of sensitisation to bakery allergens referred to a specialised clinic. METHODS: As part of a medical surveillance programme, clinical evaluation was performed on 436 referred Dutch bakery workers at high risk for sensitisation to bakery allergens...
March 17, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28304038/size-and-shape-effects-on-the-thermodynamic-properties-of-nanoscale-volumes-of-water
#8
Bjørn A Strøm, Jean-Marc Simon, Sondre K Schnell, Signe Kjelstrup, Jianying He, Dick Bedeaux
Small systems are known to deviate from the classical thermodynamic description, among other things due to their large surface area to volume ratio compared to corresponding big systems. As a consequence, extensive thermodynamic properties are no longer proportional to the volume, but are instead higher order functions of size and shape. We investigate such functions for second moments of probability distributions of fluctuating properties in the grand-canonical ensemble, focusing specifically on the volume and surface terms of Hadwiger's theorem, explained in Klain, Mathematika, 1995, 42, 329-339...
March 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28303881/corrigendum-asc-filament-formation-serves-as-a-signal-amplification-mechanism-for-inflammasomes
#9
Mathias S Dick, Lorenzo Sborgi, Sebastian Rühl, Sebastian Hiller, Petr Broz
No abstract text is available yet for this article.
March 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28302424/external-validation-of-the-universal-termination-of-resuscitation-rule-for-out-of-hospital-cardiac-arrest-in-british-columbia
#10
Brian Grunau, John Taylor, Frank X Scheuermeyer, Robert Stenstrom, William Dick, Takahisa Kawano, David Barbic, Ian Drennan, Jim Christenson
STUDY OBJECTIVE: The Universal Termination of Resuscitation Rule (TOR Rule) was developed to identify out-of-hospital cardiac arrests eligible for field termination of resuscitation, avoiding futile transportation to the hospital. The validity of the rule in emergency medical services (EMS) systems that do not routinely transport out-of-hospital cardiac arrest patients to the hospital is unknown. We seek to validate the TOR Rule in British Columbia. METHODS: This study included consecutive, nontraumatic, adult, out-of-hospital cardiac arrests treated by EMS in British Columbia from April 2011 to September 2015...
March 14, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28302148/thermal-quantitative-sensory-testing-in-healthy-dutch-children-and-adolescents-standardized-test-paradigm-and-dutch-reference-values
#11
Gerbrich E van den Bosch, Monique van Dijk, Dick Tibboel, Abraham J Valkenburg
BACKGROUND: Quantitative sensory testing (QST) is often used to measure children's and adults' detection- and pain thresholds in a quantitative manner. In children especially the Thermal Sensory Analyzer (TSA-II) is often applied to determine thermal detection and pain thresholds. As comparisons between studies are hampered by the different testing protocols used, we aimed to present a standard protocol and reference values for thermal detection- and pain thresholds in children. METHODS: Our standard testing protocol includes reaction time dependent and independent tests and takes about 14-18 min to complete...
March 16, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28301575/generation-of-murine-tumor-cell-lines-deficient-in-mhc-molecule-surface-expression-using-the-crispr-cas9-system
#12
Krishna Das, David Eisel, Clarissa Lenkl, Ashish Goyal, Sven Diederichs, Elke Dickes, Wolfram Osen, Stefan B Eichmüller
In this study, the CRISPR/Cas9 technology was used to establish murine tumor cell lines, devoid of MHC I or MHC II surface expression, respectively. The melanoma cell line B16F10 and the murine breast cancer cell line EO-771, the latter stably expressing the tumor antigen NY-BR-1 (EO-NY), were transfected with an expression plasmid encoding a β2m-specific single guide (sg)RNA and Cas9. The resulting MHC I negative cells were sorted by flow cytometry to obtain single cell clones, and loss of susceptibility of peptide pulsed MHC I negative clones to peptide-specific CTL recognition was determined by IFNγ ELISpot assay...
2017: PloS One
https://www.readbyqxmd.com/read/28299409/nothing-magical-pantomimed-grasping-is-controlled-by-the-ventral-system
#13
Thijs Rinsma, John van der Kamp, Matt Dicks, Rouwen Cañal-Bruland
In a recent amendment to the two-visual-system model, it has been proposed that actions must result in tactile contact with the goal object for the dorsal system to become engaged (Whitwell et al., Neuropsychologia 55:41-50, 2014). The present study tested this addition by assessing the use of allocentric information in normal and pantomime actions. To this end, magicians, and participants who were inexperienced in performing pantomime actions made normal and pantomime grasps toward objects embedded in the Müller-Lyer illusion...
March 15, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28298332/impact-of-lifelong-exercise-training-on-endothelial-ischemia-reperfusion-and-ischemic-preconditioning-in-humans
#14
Martijn F H Maessen, Anke Ccm van Mil, Yaïra Straathof, Niels P Riksen, Gerard A P J M Rongen, Maria T E Hopman, Thijs M H Eijsvogels, Dick H J Thijssen
Reperfusion is essential for ischemic tissue survival, but causes additional damage to the endothelium (i.e. ischemia-reperfusion [IR] injury). Ischemic preconditioning (IPC) refers to short repetitive episodes of ischemia that can protect against IR. However, IPC efficacy attenuates with older age. Whether physical inactivity contributes to the attenuated efficacy of IPC to protect against IR injury in older humans is unclear. We tested the hypotheses that lifelong exercise training relates to 1) attenuated endothelial IR and 2) maintained IPC efficacy that protects veteran athletes against endothelial IR...
March 15, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28297862/ensemble-distribution-for-immiscible-two-phase-flow-in-porous-media
#15
Isha Savani, Dick Bedeaux, Signe Kjelstrup, Morten Vassvik, Santanu Sinha, Alex Hansen
We construct an ensemble distribution to describe steady immiscible two-phase flow of two incompressible fluids in a porous medium. The system is found to be ergodic. The distribution is used to compute macroscopic flow parameters. In particular, we find an expression for the overall mobility of the system from the ensemble distribution. The entropy production at the scale of the porous medium is shown to give the expected product of the average flow and its driving force, obtained from a black-box description...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28296147/disseminated-asymptomatic-red-brown-papules-on-the-thighs
#16
Julika Dick, Wolfgang Hartschuh, Alexander H Enk, Ferdinand Toberer
No abstract text is available yet for this article.
March 15, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28295959/the-albuminuria-lowering-response-to-dapagliflozin-is-variable-and-reproducible-between-individual-patients
#17
Sergei I Petrykiv, Gozewijn D Laverman, Dick de Zeeuw, Hiddo J L Heerspink
AIMS: Albuminuria reduction is essential for renal and cardiovascular protection. We characterized the efficacy of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor, on albuminuria. Secondly, we assessed whether the albuminuria lowering effect varies between patients, and whether this variability in response is reproducible. MATERIAL AND METHODS: A double-blind, randomized, placebo controlled crossover trial was conducted. Patients with type 2 diabetes and albumin:creatinine ratio >100 mg/g on a stable dose of an Angiotensin Converting Enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) were enrolled...
March 14, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28295823/natural-variation-in-life-history-strategy-of-arabidopsis-thaliana-determines-stress-responses-to-drought-and-insects-of-different-feeding-guilds
#18
Nelson H Davila Olivas, Enric Frago, Manus P M Thoen, Karen J Kloth, Frank F M Becker, Joop J A van Loon, Gerrit Gort, Joost J B Keurentjes, Joost van Heerwaarden, Marcel Dicke
Plants are sessile organisms and, consequently, are exposed to a plethora of stresses in their local habitat. As a result, different populations of a species are subject to different selection pressures leading to adaptation to local conditions and intraspecific divergence. The annual brassicaceous plant Arabidopsis thaliana is an attractive model for ecologists and evolutionary biologists due to the availability of a large collection of re-sequenced natural accessions. Accessions of A. thaliana display one of two different life-cycle strategies: summer and winter annuals...
March 13, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28295502/assessment-of-renal-response-with-urinary-exosomes-in-patients-with-al-amyloidosis-a-proof-of-concept
#19
Marina Ramirez-Alvarado, David R Barnidge, David L Murray, Angela Dispenzieri, Marta Marin-Argany, Christopher J Dick, Shawna A Cooper, Samih H Nasr, Christopher J Ward, Surendra Dasari, Víctor H Jiménez-Zepeda, Nelson Leung
Immunoglobulin light chain (AL) amyloidosis is a fatal complication of B-cell proliferation secondary to deposition of amyloid fibrils in various organs. Urinary exosomes (UEX) are the smallest of the microvesicles excreted in the urine. Previously, we found UEX of patients with AL amyloidosis contained immunoglobulin light chain (LC) oligomers that patients with multiple myeloma did not have. To further explore the role of the LC oligomers, UEX was isolated from an AL amyloidosis patient with progressive renal disease despite achieving a complete response...
March 10, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28294651/a-breath-of-fresh-air-for-patients-with-pulmonary-nontuberculous-mycobacterial-infection
#20
Jason E Stout, Kristen V Dicks
No abstract text is available yet for this article.
March 15, 2017: American Journal of Respiratory and Critical Care Medicine
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