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mtDNA content oxidative stress

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https://www.readbyqxmd.com/read/28625088/mitochondrial-content-and-hepcidin-are-increased-in-obese-pregnant-mothers
#1
G M Anelli, M Cardellicchio, C Novielli, P Antonazzo, M I Mazzocco, I Cetin, C Mandò
OBJECTIVE: Maternal obesity is characterized by systemic low-grade inflammation and oxidative stress (OxS) with the contribution of fetal sex dimorphism. We recently described increased mitochondrial content (mtDNA) in placentas of obese pregnancies. Here we quantify mtDNA and hepcidin as indexes of OxS and systemic inflammation in the obese maternal circulation. METHODS: Forty-one pregnant women were enrolled at elective Caesarean section: 16 were normal-weight [NW] and 25 were obese (OB)...
June 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28623975/mitochondrial-dna-content-and-methylation-in-fetal-cord-blood-of-pregnancies-with-placental-insufficiency
#2
Chiara Novielli, Chiara Mandò, Silvia Tabano, Gaia M Anelli, Laura Fontana, Patrizio Antonazzo, Monica Miozzo, Irene Cetin
INTRODUCTION: Intrauterine growth restriction (IUGR) and preeclampsia (PE) are pregnancy disorders characterized by placental insufficiency with oxygen/nutrient restriction and oxidative stress, all influencing mitochondria functionality and number. Moreover, IUGR and PE fetuses are predisposed to diseases later in life, and this might occur through epigenetic alterations. Here we analyze content and methylation of mitochondrial DNA (mtDNA), for the first time in IUGR and PE singleton fetuses, to identify possible alterations in mtDNA levels and/or epigenetic control of mitochondrial loci relevant to replication (D-loop) and functionality (mt-TF/RNR1: protein synthesis, mt-CO1: respiratory chain complex)...
July 2017: Placenta
https://www.readbyqxmd.com/read/28581828/biomarkers-used-in-studying-air-pollution-exposure-during-pregnancy-and-perinatal-outcomes-a-review
#3
Gauri Desai, Li Chu, Yanjun Guo, Ajay A Myneni, Lina Mu
PURPOSE: This review focuses on studies among pregnant women that used biomarkers to assess air pollution exposure, or to understand the mechanisms by which it affects perinatal outcomes. METHODS: We searched PubMed and Google scholar databases to find articles. RESULTS AND CONCLUSIONS: We found 29 articles, mostly consisting of cohort studies. Interpolation models were most frequently used to assess exposure. The most consistent positive association was between polycyclic aromatic hydrocarbon (PAH) exposure during entire pregnancy and cord blood PAH DNA adducts...
June 21, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28551797/peripheral-blood-mitochondrial-dna-and-myocardial-function
#4
Tatiana Kuznetsova, Judita Knez
Heart failure is a complex progressive clinical syndrome which is initiated by risk factors (e.g., hypertension, obesity, and diabetes), then proceeds to asymptomatic maladaptive left ventricular remodeling and dysfunction, and finally evolves into clinically overt, symptomatic heart failure, disability, and death. The progression of left ventricular dysfunction is associated with changes in cardiac energy metabolism. Mitochondria play a central role in a variety of cardiomyocytes functions, including oxidative energy production, storage of calcium ions, and programmed cell death...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28535425/prenatal-ambient-air-pollution-exposure-infant-growth-and-placental-mitochondrial-dna-content-in-the-inma-birth-cohort
#5
Diana B P Clemente, Maribel Casas, Bram G Janssen, Aitana Lertxundi, Loreto Santa-Marina, Carmen Iñiguez, Sabrina Llop, Jordi Sunyer, Mònica Guxens, Tim S Nawrot, Martine Vrijheid
BACKGROUND: The association between prenatal air pollution exposure and postnatal growth has hardly been explored. Mitochondrial DNA (mtDNA), as a marker of oxidative stress, and growth at birth can play an intermediate role in this association. OBJECTIVE: In a subset of the Spanish birth cohort INMA we assessed first whether prenatal nitrogen dioxide (NO2) exposure is associated with infant growth. Secondly, we evaluated whether growth at birth (length and weight) could play a mediating role in this association...
August 2017: Environmental Research
https://www.readbyqxmd.com/read/28409883/melanocortin-4-receptor-activation-attenuates-mitochondrial-dysfunction-in-skeletal-muscle-of-diabetic-rats
#6
Hao-Hao Zhang, Jiao Liu, Gui-Jun Qin, Xia-Lian Li, Pei-Jie Du, Xiao Hao, Tian-Tian Tian, Jing- Wu, Meng- Yun, Yan-Hui Bai
Backgroud: A previous study has confirmed that the central melanocortin system was able to mediate skeletal muscle AMP-activated protein kinase (AMPK) activation in mice fed a high-fat diet, while activation of the AMPK signaling pathway significantly induced mitochondrial biogenesis. Our hypothesis was that melanocortin 4 receptor (MC4R) was involved in the development of skeletal muscle injury in diabetic rats. METHODS: In this study, we treated diabetic rats intracerebroventricularly with MC4R agonist R027-3225 or antagonist SHU9119, respectively...
April 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28359291/curcumin-suppresses-gastric-tumor-cell-growth-via-ros-mediated-dna-polymerase-%C3%AE-depletion-disrupting-cellular-bioenergetics
#7
Lihua Wang, Xiwen Chen, Zhuanyun Du, Gefei Li, Mayun Chen, Xi Chen, Guang Liang, Tongke Chen
BACKGROUND: Curcumin, as a pro-apoptotic agent, is extensively studied to inhibit tumor cell growth of various tumor types. Previous work has demonstrated that curcumin inhibits cancer cell growth by targeting multiple signaling transduction and cellular processes. However, the role of curcumin in regulating cellular bioenergetic processes remains largely unknown. METHODS: Western blotting and qRT-PCR were performed to analyze the protein and mRNA level of indicated molecules, respectively...
March 31, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28306143/mutant-eif2b-leads-to-impaired-mitochondrial-oxidative-phosphorylation-in-vanishing-white-matter-disease
#8
Gali Raini, Reut Sharet, Melisa Herrero, Andrea Atzmon, Anjana Shenoy, Tamar Geiger, Orna Elroy-Stein
Eukaryotic translation initiation factor 2B (eIF2B) is a master regulator of protein synthesis under normal and stress conditions. Mutations in any of the five genes encoding its subunits lead to vanishing white matter (VWM) disease, a recessive genetic deadly illness caused by progressive loss of white matter in the brain. In this study we used fibroblasts, which are not involved in the disease, to demonstrate the involvement of eIF2B in mitochondrial function and abundance. Mass spectrometry of total proteome of mouse embryonic fibroblasts (MEFs) isolated from Eif2b5(R132H/R132H) mice revealed unbalanced stoichiometry of proteins involved in oxidative phosphorylation and of mitochondrial translation machinery components, among others...
March 17, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28242046/association-between-peripheral-blood-cells-mitochondrial-dna-content-and-severity-of-coronary-heart-disease
#9
Li-Peng Liu, Kang Cheng, Ming-An Ning, Hong-Hong Li, Hai-Chang Wang, Fei Li, Shu-Ying Chen, Fa-Lin Qu, Wen-Yi Guo
BACKGROUND AND AIMS: Leukocyte mitochondrial DNA (mtDNA) content reflects the oxidant-induced cell damage, which has been observed in a wide range of cardiovascular diseases. However, whether it correlates with coronary heart disease (CHD), which closely relates to oxidative stress, has never been elucidated before. The aim of this study was to explore association between mtDNA content and the presence and severity of CHD. METHODS: The study population consisted of 400 individuals (290 with CHD and 110 controls)...
February 20, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28133770/in-vitro-antioxidant-effect-of-curcumin-on-human-sperm-quality-in-leucocytospermia
#10
L Zhang, R Y Diao, Y G Duan, T H Yi, Z M Cai
Decreased sperm quality was caused by oxidative stress in semen from patients with leucocytospermia. Curcumin is a traditional Chinese herbal monomer extracted from Zingiberaceae turmeric and zedoary turmeric and has antioxidative and anti-inflammatory effects. This study aimed to investigate the effects and specific molecular mechanisms of curcumin on sperm quality in patients diagnosed with leucocytospermia. Forty cases of semen samples were collected from patients with leucocytospermia and 35 cases from normal fertile male...
January 30, 2017: Andrologia
https://www.readbyqxmd.com/read/28111084/prepregnancy-maternal-diabetes-combined-with-obesity-impairs-placental-mitochondrial-function-involving-nrf2-are-pathway-and-detrimentally-alters-metabolism-of-offspring
#11
Yang Duan, Fuqiang Sun, Shengshun Que, Yueqin Li, Suyan Yang, Geli Liu
Metabolic disorders usually increase the level of reactive oxygen species (ROS) and damage mitochondrial function. The placenta supplies nutrients and hormonal signals to the fetus for regulating fetal metabolism, and is also prone to injury by oxidants. The aim of this study was to determine the effect of pre-existing maternal type 2 diabetes mellitus (DM) combined with obesity on placental mitochondrial function and metabolism disorders of offspring. The study included 96 pregnant women. The women were put into the following groups: healthy women (control, n=24), women with DM (DM, n=24), women with obesity (OB, n=24) and women with both DM and obesity (DM+OB, n=24)...
January 19, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27993944/effects-of-airborne-toxicants-on-pulmonary-function-and-mitochondrial-dna-damage-in-rodent-lungs
#12
William L Rumsey, Brian Bolognese, Alicia B Davis, Pearl L Flamberg, Joseph P Foley, Steven R Katchur, Charles J Kotzer, Ruth R Osborn, Patricia L Podolin
Inhalation of airborne toxicants such as cigarette smoke and ozone is a shared health risk among the world's populations. The use of toxic herbicides like paraquat (PQ) is restricted by many countries, yet in the developing world PQ has demonstrable ill effects. The present study examined changes in pulmonary function, mitochondrial DNA (mtDNA) integrity and markers of DNA repair induced by acute or repeated exposure of PQ to rats. Similar to cigarette smoke and ozone, PQ promotes oxidative stress, and the impact of PQ on mtDNA was compared with that obtained with these agents...
May 1, 2017: Mutagenesis
https://www.readbyqxmd.com/read/27906110/failed-upregulation-of-tfam-protein-and-mitochondrial-dna-in-oxidatively-deficient-fibers-of-chronic-obstructive-pulmonary-disease-locomotor-muscle
#13
Yana Konokhova, Sally Spendiff, R Thomas Jagoe, Sudhakar Aare, Sophia Kapchinsky, Norah J MacMillan, Paul Rozakis, Martin Picard, Mylène Aubertin-Leheudre, Charlotte H Pion, Jean Bourbeau, Russell T Hepple, Tanja Taivassalo
BACKGROUND: Low mitochondrial content and oxidative capacity are well-established features of locomotor muscle dysfunction, a prevalent and debilitating systemic occurrence in patients with chronic obstructive pulmonary disease (COPD). Although the exact cause is not firmly established, physical inactivity and oxidative stress are among the proposed underlying mechanisms. Here, we assess the impact of COPD pathophysiology on mitochondrial DNA (mtDNA) integrity, biogenesis, and cellular oxidative capacity in locomotor muscle of COPD patients and healthy controls...
February 18, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27894409/the-effects-of-mitochondrial-dna-deletion-and-copy-number-variations-on-different-exercise-intensities-in-highly-trained-swimmers
#14
O Baykara, S K Sahin, F Akbas, M Guven, I Onaran
It has been suggested that heavy exercise might increase oxidative stress, causing mitochondrial DNA (mtDNA) mutations as well as DNA mutations and changes in the mtDNA copy number in cells. mtDNA4977 deletion is one of the most common deletions seen on mitochondria. We hypothesize association between exercise induced oxidative stress and mtDNA damage in peripheral blood lymphocytes (PBLs) of highly trained swimmers. Therefore we studied the mtDNA4977 deletion level, mtDNA copy number and their relationship with cellular ATP and oxidative stress status in PBLs of swimmers...
October 31, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27843010/identifying-sensitive-windows-for-prenatal-particulate-air-pollution-exposure-and-mitochondrial-dna-content-in-cord-blood
#15
Maria José Rosa, Allan C Just, Marco Sánchez Guerra, Itai Kloog, Hsiao-Hsien Leon Hsu, Kasey J Brennan, Adriana Mercado García, Brent Coull, Rosalind J Wright, Martha María Téllez Rojo, Andrea A Baccarelli, Robert O Wright
INTRODUCTION: Changes in mitochondrial DNA (mtDNA) can serve as a marker of cumulative oxidative stress (OS) due to the mitochondria's unique genome and relative lack of repair systems. In utero particulate matter ≤2.5μm (PM2.5) exposure can enhance oxidative stress. Our objective was to identify sensitive windows to predict mtDNA damage experienced in the prenatal period due to PM2.5 exposure using mtDNA content measured in cord blood. MATERIAL AND METHODS: Women affiliated with the Mexican social security system were recruited during pregnancy in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) study...
January 2017: Environment International
https://www.readbyqxmd.com/read/27783701/decreased-integrity-content-and-increased-transcript-level-of-mitochondrial-dna-are-associated-with-keratoconus
#16
Xiao-Dan Hao, Zhao-Li Chen, Ming-Li Qu, Xiao-Wen Zhao, Su-Xia Li, Peng Chen
Oxidative stress may play an important role in the pathogenesis of keratoconus (KC). Mitochondrial DNA (mtDNA) is involved in mitochondrial function, and the mtDNA content, integrity, and transcript level may affect the generation of reactive oxygen species (ROS) and be involved in the pathogenesis of KC. We designed a case-control study to research the relationship between KC and mtDNA integrity, content and transcription. One-hundred ninety-eight KC corneas and 106 normal corneas from Chinese patients were studied...
2016: PloS One
https://www.readbyqxmd.com/read/27764247/sirt1-pgc1%C3%AE-nf%C3%AE%C2%BAb-pathway-of-oxidative-and-inflammatory-stress-during-trypanosoma-cruzi-infection-benefits-of-sirt1-targeted-therapy-in-improving-heart-function-in-chagas-disease
#17
Xianxiu Wan, Jian-Jun Wen, Sue-Jie Koo, Lisa Yi Liang, Nisha Jain Garg
Chronic chagasic cardiomyopathy (CCM) is presented by increased oxidative/inflammatory stress and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and integrates mitochondrial metabolism and inflammation; and SIRT1 deficiency may be a major determinant in CCM. To test this, C57BL/6 mice were infected with Trypanosoma cruzi (Tc), treated with SIRT1 agonists (resveratrol or SRT1720), and monitored during chronic phase (~150 days post-infection). Resveratrol treatment was partially beneficial in controlling the pathologic processes in Chagas disease...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27710240/differences-in-mitochondrial-coupling-reveal-a-novel-signature-of-mitohormesis-in-muscle-of-healthy-individuals
#18
Lauren M Sparks, Leanne M Redman, Kevin E Conley, Mary-Ellen Harper, Andrew Hodges, Alexey Eroshkin, Sheila R Costford, Meghan E Gabriel, Fanchao Yi, Cherie Shook, Heather H Cornnell, Eric Ravussin, Steven R Smith
CONTEXT: Reduced mitochondrial coupling (ATP/O2 [P/O]) is associated with sedentariness and insulin resistance. Interpreting the physiological relevance of P/O measured in vitro is challenging. OBJECTIVE: To evaluate muscle mitochondrial function and associated transcriptional profiles in nonobese healthy individuals distinguished by their in vivo P/O. DESIGN: Individuals from an ancillary study of Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy phase 2 were assessed at baseline...
December 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27626906/troxerutin-attenuates-diet-induced-oxidative-stress-impairment-of-mitochondrial-biogenesis-and-respiratory-chain-complexes-in-mice-heart
#19
Geetha Rajagopalan, Sathiya Priya Chandrasekaran, Anuradha Carani Venkatraman
Mitochondrial abnormality is thought to play a key role in cardiac disease originating from the metabolic syndrome (MS). We evaluated the effect of troxerutin (TX), a semi-synthetic derivative of the natural bioflavanoid rutin, on the respiratory chain complex activity, oxidative stress, mitochondrial biogenesis and dynamics in heart of high fat, high fructose diet (HFFD) -induced mouse model of MS. Adult male Mus musculus mice of body weight 25-30 g were fed either control diet or HFFD for 60 days. Mice from each dietary regimen were divided into two groups on the 16th day and were treated or untreated with TX (150 mg/kg body weight [bw], per oral) for the next 45 days...
January 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27162261/mitochondrial-dysfunction-and-oxidative-stress-in-patients-with-chronic-kidney-disease
#20
Jorge L Gamboa, Frederic T Billings, Matthew T Bojanowski, Laura A Gilliam, Chang Yu, Baback Roshanravan, L Jackson Roberts, Jonathan Himmelfarb, T Alp Ikizler, Nancy J Brown
Mitochondria abnormalities in skeletal muscle may contribute to frailty and sarcopenia, commonly present in patients with chronic kidney disease (CKD). Dysfunctional mitochondria are also a major source of oxidative stress and may contribute to cardiovascular disease in CKD We tested the hypothesis that mitochondrial structure and function worsens with the severity of CKD Mitochondrial volume density, mitochondrial DNA (mtDNA) copy number, BNIP3, and PGC1α protein expression were evaluated in skeletal muscle biopsies obtained from 27 subjects (17 controls and 10 with CKD stage 5 on hemodialysis)...
May 2016: Physiological Reports
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