Jiadan Qu, Yunyao Luo, Lifeng Qin, Jing Guo, Ling Zhu, Chong Li, Juan Xie, Chunmeng Shi, Guoning Huang, Jingyu Li
Postovulatory aging can trigger deterioration of oocyte quality and subsequent embryonic development, and thus reduce the success rates of assisted reproductive technology (ART). The molecular mechanisms underlying postovulatory aging, and preventative strategies, remain to be explored. The near-infrared fluorophore IR-61, a novel heptamethine cyanine dye, has the potential for mitochondrial targeting and cell protection. In this study, we found that IR-61 accumulated in oocyte mitochondria and reduced the postovulatory aging-induced decline in mitochondrial function, including mitochondrial distribution, membrane potential, mtDNA number, ATP levels, and mitochondrial ultrastructure...
July 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology