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Clarity for mapping

Lisa Holmlund, Claes Hultling, Eric Asaba
Involving persons with spinal cord injury (SCI) as experts in their lives is important for research to design relevant health care interventions. The purpose of this study was to use photovoice methods to explore experiences of barriers and possibilities in return to work among working adults with SCI. The photovoice group consisted of six persons living with SCI that met weekly over 2 months to share and discuss photos related to return to work. Five themes were identified: (a) there is only one way, (b) welcome back-or not, (c) to be like anyone else-or to be perceived as someone else, (d) friction in the absence of clarity, and (e) finding integrated strategies for everyday life with work...
June 1, 2018: Qualitative Health Research
Bettina Nielsen, Kari Slinning, Hanne Weie Oddli, Filip Drozd
BACKGROUND: A reoccurring finding from health and clinical services is the failure to implement theory and research into practice and policy in appropriate and efficient ways, which is why it is essential to develop and identify implementation strategies, as they constitute the how-to component of translating and changing health practices. OBJECTIVE: The aim of this study was to provide a systematic and comprehensive review of the implementation strategies that have been applied for the Circle of Security-Virginia Family (COS-VF) model by developing an implementation protocol...
June 14, 2018: JMIR Research Protocols
Lin-Yuan Zhang, Pan Lin, Jiaji Pan, Yuanyuan Ma, Zhenyu Wei, Lu Jiang, Liping Wang, Yaying Song, Yongting Wang, Zhijun Zhang, Kunlin Jin, Qian Wang, Guo-Yuan Yang
Elucidating the normal structure and distribution of cerebral vascular system is fundamental for understanding its function. However, studies on visualization and whole-brain quantification of vasculature with cellular resolution are limited. Here, we explored the structure of vasculature at the whole-brain level using the newly developed CLARITY technique. Adult male C57BL/6J mice undergoing transient middle cerebral artery occlusion and Tie2-RFP transgenic mice were used. Whole mouse brains were extracted for CLARITY processing...
April 2018: Aging and Disease
Andrew D Boyd, Jianrong 'John' Li, Colleen Kenost, Samir Rachid Zaim, Jacob Krive, Manish Mittal, Richard A Satava, Michael Burton, Jacob Smith, Yves A Lussier
The transition of procedure coding from ICD-9-CM-Vol-3 to ICD-10-PCS has generated problems for the medical community at large resulting from the lack of clarity required to integrate two non-congruent coding systems. We hypothesized that quantifying these issues with network topology analyses offers a better understanding of the issues, and therefore we developed solutions (online tools) to empower hospital administrators and researchers to address these challenges. Five topologies were identified: "identity"(I), "class-to-subclass"(C2S), "subclass-toclass"(S2C), "convoluted(C)", and "no mapping"(NM)...
2018: AMIA Summits on Translational Science Proceedings
Nicole G Weiskopf, Suzanne Bakken, George Hripcsak, Chunhua Weng
Introduction: We describe the formulation, development, and initial expert review of 3x3 Data Quality Assessment (DQA), a dynamic, evidence-based guideline to enable electronic health record (EHR) data quality assessment and reporting for clinical research. Methods: 3x3 DQA was developed through the triangulation results from three studies: a review of the literature on EHR data quality assessment, a quantitative study of EHR data completeness, and a set of interviews with clinical researchers...
September 4, 2017: EGEMS
Laura Desveaux, Anna R Gagliardi
BACKGROUND: Post-market surveillance of medical devices is reliant on physician reporting of adverse medical device events (AMDEs). Few studies have examined factors that influence whether and how physicians report AMDEs, an essential step in the development of behaviour change interventions. This study was a secondary analysis comparing application of the Theoretical Domains Framework (TDF) and the Tailored Implementation for Chronic Diseases (TICD) framework to identify potential behaviour change interventions that correspond to determinants of AMDE reporting...
June 4, 2018: BMC Health Services Research
Stephanie M Topp, Alexandra Edelman, Sean Taylor
BACKGROUND: Health policy in Australia positions Aboriginal and Torres Strait Islander Health Workers (AHWs) as central to improving Aboriginal and Torres Strait Islander peoples' health, with high expectations of their contribution to closing the gap between Indigenous and non-Indigenous health outcomes. Understanding how AHWs' governance and accountability relationships influence their ability to address such health inequities has policy, programme and ethical significance. We sought to map the evidence of AHWs' experiences of accountability in the Australian health system...
May 30, 2018: International Journal for Equity in Health
Jiwon Woo, Eunice Yoojin Lee, Hyo-Suk Park, Jeong Yoon Park, Yong Eun Cho
Since the development of CLARITY, a bioelectrochemical clearing technique that allows for three-dimensional phenotype mapping within transparent tissues, a multitude of novel clearing methodologies including CUBIC (clear, unobstructed brain imaging cocktails and computational analysis), SWITCH (system-wide control of interaction time and kinetics of chemicals), MAP (magnified analysis of the proteome), and PACT (passive clarity technique), have been established to further expand the existing toolkit for the microscopic analysis of biological tissues...
May 8, 2018: Journal of Visualized Experiments: JoVE
Ling Huang, Xiaohui Deng, Ronghua Li, Yanshi Xia, Guihua Bai, Kadambot H M Siddique, Peiguo Guo
Simple Sequence Repeat (SSR) is one of the most effective markers used in plant and animal genetic research and molecular breeding programs. Silver staining is a widely used method for the detection of SSR markers in a polyacrylamide gel. However, conventional protocols for silver staining are technically demanding and time-consuming. Like many other biological laboratory techniques, silver staining protocols have been steadily optimized to improve detection efficiency. Here, we report a simplified silver staining method that significantly reduces reagent costs and enhances the detection resolution and picture clarity...
April 20, 2018: Journal of Visualized Experiments: JoVE
Ashok Mondal, Poulami Banerjee, Hong Tang
BACKGROUND AND OBJECTIVE: The stethoscope based auscultation technique is a primary diagnostic tool for chest sound analysis. However, the performance of this method is limited due to its dependency on physicians experience, knowledge and also clarity of the signal. To overcome this problem we need an automated computer-aided diagnostic system that will be competent in noisy environment. In this paper, a novel feature extraction technique is introduced for discriminating various pulmonary dysfunctions in an automated way based on pattern recognition algorithms...
June 2018: Computer Methods and Programs in Biomedicine
Mark Rodgers, Jane Dalton, Melissa Harden, Andrew Street, Gillian Parker, Alison Eastwood
People with mental health conditions have a lower life expectancy and poorer physical health outcomes than the general population. Evidence suggests this is due to a combination of clinical risk factors, socioeconomic factors, and health system factors, notably a lack of integration when care is required across service settings. Several recent reports have looked at ways to better integrate physical and mental health care for people with severe mental illness (SMI). We built on these by conducting a mapping review that looked for the most recent evidence and service models in this area...
January 25, 2018: International Journal of Integrated Care
Yana A Lyon, Georgette M Sabbah, Ryan R Julian
Although it is well-known that protein turnover essentially stops in mature lens fiber cells, mapping out the ensuing protein degradation and its effects on lens function over time remains challenging. In particular, isomerization is a common, spontaneous post-translational modification that occurs over long timescales and generates products invisible to most analytical methods. Nevertheless, isomerization can significantly impact protein structure, function, and solubility, which are all necessary to maintain clarity and proper refractive index within the lens...
June 2018: Experimental Eye Research
Amanda L Roze des Ordons, Tasnim Sinuff, Henry T Stelfox, Jane Kondejewski, Shane Sinclair
CONTEXT: Spiritual distress contributes to patients' and families' experiences of care. OBJECTIVES: To map the literature on how seriously ill patients and their family members experience spiritual distress within inpatient settings. METHODS: Our scoping review included four databases using search terms "existential" or "spiritual" combined with "angst," "anxiety," "distress," "stress," or "anguish...
March 14, 2018: Journal of Pain and Symptom Management
Rebecca Feo, Alison Kitson, Tiffany Conroy
AIMS AND OBJECTIVES: To investigate how fundamental aspects of nursing care have been defined in the literature from 2010-2016. BACKGROUND: A 2010 narrative review of nursing texts identified little consensus on what constitutes the fundamental aspects of nursing care. Since then there has been a proliferation of policies, strategic frameworks and research teams dedicated to investigating such care. It is unclear whether this increased activity has led to greater conceptual clarity...
March 7, 2018: Journal of Clinical Nursing
Eva Serhal, Amanda Arena, Sanjeev Sockalingam, Linda Mohri, Allison Crawford
The Project Extension for Community Healthcare Outcomes (ECHO) model expands primary care provider (PCP) capacity to manage complex diseases by sharing knowledge, disseminating best practices, and building a community of practice. The model has expanded rapidly, with over 140 ECHO projects currently established globally. We have used validated implementation frameworks, such as Damschroder's (2009) Consolidated Framework for Implementation Research (CFIR) and Proctor's (2011) taxonomy of implementation outcomes, combined with implementation experience to (1) create a set of questions to assess organizational readiness and suitability of the ECHO model and (2) provide those who have determined ECHO is the correct model with a checklist to support successful implementation...
March 1, 2018: Journal of Continuing Education in the Health Professions
Anna Beyeler, Chia-Jung Chang, Margaux Silvestre, Clémentine Lévêque, Praneeth Namburi, Craig P Wildes, Kay M Tye
The basolateral amygdala (BLA) mediates associative learning for both fear and reward. Accumulating evidence supports the notion that different BLA projections distinctly alter motivated behavior, including projections to the nucleus accumbens (NAc), medial aspect of the central amygdala (CeM), and ventral hippocampus (vHPC). Although there is consensus regarding the existence of distinct subsets of BLA neurons encoding positive or negative valence, controversy remains regarding the anatomical arrangement of these populations...
January 23, 2018: Cell Reports
Terence P Mayne, Niranchan Paskaranandavadivel, Jonathan C Erickson, Gregory OGrady, Leo K Cheng, Timothy R Angeli
OBJECTIVE: High-resolution mapping of gastrointestinal (GI) slow waves is a valuable technique for research and clinical applications. Interpretation of high-resolution GI mapping data relies on animations of slow wave propagation, but current methods remain as rudimentary, pixelated electrode activation animations. This study aimed to develop improved methods of visualizing high-resolution slow wave recordings that increases ease of interpretation. METHODS: The novel method of "wavefront-orientation" interpolation was created to account for the planar movement of the slow wave wavefront, negate any need for distance calculations, remain robust in atypical wavefronts (i...
February 2018: IEEE Transactions on Bio-medical Engineering
Pierre Petitet, Jill X O'Reilly, Jacinta O'Shea
Prism adaptation has a long history as an experimental paradigm used to investigate the functional and neural processes that underlie sensorimotor control. In the neuropsychology literature, prism adaptation behaviour is typically explained by reference to a traditional cognitive psychology framework that distinguishes putative functions, such as 'strategic control' versus 'spatial realignment'. This theoretical framework lacks conceptual clarity, quantitative precision and explanatory power. Here, we advocate for an alternative computational framework that offers several advantages: 1) an algorithmic explanatory account of the computations and operations that drive behaviour; 2) expressed in quantitative mathematical terms; 3) embedded within a principled theoretical framework (Bayesian decision theory, state-space modelling); 4) that offers a means to generate and test quantitative behavioural predictions...
December 14, 2017: Neuropsychologia
Andreas Xyrichis, Scott Reeves, Merrick Zwarenstein
The practice of, and research on interprofessional working in healthcare, commonly referred to as teamwork, has been growing rapidly. This has attracted international policy support flowing from the growing belief that patient safety and quality of care can only be achieved through the collective effort of the multiple professionals caring for a given patient. Despite the increasing policy support, the evidence for effectiveness lags behind: while there are supporting analytic epidemiological studies, few reliable intervention studies have been published and so we have yet to confirm a causal link...
December 13, 2017: Journal of Interprofessional Care
Markus Morawski, Evgeniya Kirilina, Nico Scherf, Carsten Jäger, Katja Reimann, Robert Trampel, Filippos Gavriilidis, Stefan Geyer, Bernd Biedermann, Thomas Arendt, Nikolaus Weiskopf
Recent breakthroughs in magnetic resonance imaging (MRI) enabled quantitative relaxometry and diffusion-weighted imaging with sub-millimeter resolution. Combined with biophysical models of MR contrast the emerging methods promise in vivo mapping of cyto- and myelo-architectonics, i.e., in vivo histology using MRI (hMRI) in humans. The hMRI methods require histological reference data for model building and validation. This is currently provided by MRI on post mortem human brain tissue in combination with classical histology on sections...
November 28, 2017: NeuroImage
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