Vishwa A Khatri, Sambuddha Paul, Niraj Jatin Patel, Sahaja Thippani, Janhavi Y Sawant, Katie L Durkee, Cassandra L Murphy, Geneve Ortiz Aleman, Justine A Valentino, Jasmine Jathan, Anthony Melillo, Eva Sapi
The bacterial spirochete Borrelia burgdorferi, the causative agent of Lyme Disease, can disseminate and colonize various tissues and organs, orchestrating severe clinical symptoms including arthritis, carditis, and neuroborreliosis. Previous research has demonstrated that breast cancer tissues could provide an ideal habitat for diverse populations of bacteria, including B. burgdorferi, which is associated with a poor prognosis. Recently, we demonstrated that infection with B. burgdorferi enhances the invasion and migration of triple-negative MDA-MB-231 cells which represent a type of breast tumor with more aggressive cancer traits...
October 19, 2023: European Journal of Microbiology & Immunology